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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAD18 Gene

protein-coding   GIFtS: 57
GCID: GC03M008896

RAD18 homolog (S. cerevisiae)
 Explore 8 diseases affiliated with
RAD18 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RAD18    

Aliases
for RAD18 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
RAD18 Homolog (S. Cerevisiae)1 2     RING Finger Protein 732 3
RNF731 2 3     E3 Ubiquitin-Protein Ligase RAD182
Postreplication Repair Protein RAD182 3     Postreplication Repair Protein HRAD18p2
HHR181     RAD18, S. Cerevisiae, Homolog2
HRAD181     EC 6.3.2.-3

External Ids:    HGNC: 182781   Entrez Gene: 568522   Ensembl: ENSG000000709507   OMIM: 6052565   UniProtKB: Q9NS913   

Export aliases for RAD18 gene to outside databases

Previous GC identifer: GC03M008850


Summaries
for RAD18 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RAD18:
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18
functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication
repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of
yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of
UV-damaged DNA and hypersensitivity to multiple mutagens. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RAD18_HUMAN, Q9NS91
Function: E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair
functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin
conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of
DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity

Gene Wiki entry for RAD18


Genomic Views
for RAD18 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAD18 gene promoter:
         GR   STAT1   FOXF2   STAT1beta   CUTL1   STAT1alpha   GATA-2   C/EBPalpha   Egr-2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RAD18 promoter sequence
   Search SABiosciences Chromatin IP Primers for RAD18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAD18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25-p24   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p25-p24

RAD18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAD18 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M008896:  view genomic region     (about GC identifiers)

Start:
 8,817,088 bp from pter      End:
 9,005,457 bp from pter
Size:
 188,370 bases      Orientation:
 minus strand

Proteins
for RAD18 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RAD18_HUMAN, Q9NS91 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RAD18  
Size: 495 amino acids; 56223 Da
Subunit: Interacts with UBE2A and UBE2B. Interacts with HLTF and SHPRH. Interacts with SPRTN; leading to enhance
chromatin association of RAD18 and RAD18-mediated PCNA ubiquitination and translesion DNA synthesis
Subcellular location: Nucleus (By similarity)
2 PDB 3D structures from and Proteopedia for RAD18:
2Y43 (3D)        2YBF (3D)    
Secondary accessions: Q58F55 Q9NRT6

Explore the universe of human proteins at neXtProt for RAD18: NX_Q9NS91

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NS91

    • RAD18 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_064550.3  
    ENSEMBL proteins: 
     ENSP00000412054   ENSP00000264926   ENSP00000402049   ENSP00000393783   ENSP00000397852  
     ENSP00000399620   ENSP00000412261  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: RAD18
    OriGene Protein Over-expression Lysate: RAD18
    OriGene Custom Protein Services for RAD18 
    GenScript Custom Purified and Recombinant Proteins Services for RAD18
    Novus Biologicals RAD18 Proteins
    Novus Biologicals RAD18 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RAD18

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IEA--
    GO:0001741XY body IEA--
    GO:0005634nucleus NAS10884424
    GO:0005657replication fork IDA18363965


    RAD18 for ontologies           About GeneDecksing



    RAD18 Antibody Products: 
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    Uscn Antibodies for RAD18
    ThermoFisher Antibodies for RAD18

    Assay Products for RAD18: 
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    Browse OriGene Fluorogenic Cell Assay Kits
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    GenScript Custom Assay Services for RAD18
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RAD18

    Protein Domains /
    Families
    for RAD18 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RAD18 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR017907 Znf_RING_CS
     IPR006642 Znf_Rad18_put
     IPR003034 SAP_dom

    Graphical View of Domain Structure for InterPro Entry Q9NS91

    ProtoNet protein and cluster: Q9NS91

    3 Blocks protein families:
    IPB001841 Zn-finger
    IPB003034 DNA-binding SAP
    IPB006642 Zn-finger Rad18


    UniProtKB/Swiss-Prot: RAD18_HUMAN, Q9NS91
    Similarity: Belongs to the RAD18 family
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 SAP domain
    Similarity: Contains 1 UBZ-type zinc finger


    Function
    for RAD18 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RAD18_HUMAN, Q9NS91
    Function: E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair
    functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin
    conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of
    DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
    Products:            		 OriGene 3'-UTR Clone: RAD18
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAD18
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate RAD18 (see all 26):
    hsa-miR-1178 hsa-miR-520e hsa-miR-302d hsa-miR-495 hsa-miR-302e hsa-miR-519a hsa-miR-570 hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmid: RAD18 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAD18 (see all 7)
    OriGene shRNA RFP: RAD18
    OriGene siRNA: RAD18
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAD18

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RAD18

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAD18 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAD18 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RAD18 (NM_020165)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAD18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD18 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for RAD18
    Search LifeMap BioReagents cell lines for RAD18

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD18

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000403Y-form DNA binding IDA18363965
    GO:0003677DNA binding ----
    GO:0003684damaged DNA binding NAS10884424
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--


    RAD18 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for RAD18:
     Decreased cilium length after   Decreased viability with cispl  Increased cell death in HCT116 

    Animal Models:
         Mouse knock-out Rad18tm1Stat for RAD18
         6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Rad18):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     reproductive system 

    RAD18 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RAD18 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1DNA Damage
    		DNA Damage1.00
    2Cell Cycle / Checkpoint Control
    		Cell Cycle / Checkpoint Control1.00
    3APC-Cdc20 mediated degradation of Nek2A
    		Common schema of ubiquitination0.35

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for RAD18
        Common schema of ubiquitination


    2 Cell Signaling Technology (CST) Pathways for RAD18
        Cell Cycle / Checkpoint Control
    DNA Damage


    UniProtKB/Swiss-Prot: RAD18_HUMAN, Q9NS91
    Pathway: Protein modification; protein ubiquitination


    RAD18 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAD18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/762 Interacting proteins for RAD18 (Q9NS912, 3 ENSP000002649264) via UniProtKB, MINT, STRING, and/or I2D (see all 762)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSG101Q998162, 3, ENSP000002519684MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000251968
    FANCIQ9NVI12, 3, ENSP000003108424MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000310842
    HLTFQ145272, 3, ENSP000003089444MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000308944
    SRRM2Q9UQ352, 3, ENSP000003017404MINT-7945693 I2D: score=1 STRING: ENSP00000301740
    NBNO609342, 3, ENSP000002654334MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000265433
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair NAS10884424
    GO:0006974response to DNA damage stimulus ----
    GO:0007283spermatogenesis IEA--
    GO:0009411response to UV IEA--
    GO:0016567protein ubiquitination IEA--


    RAD18 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RAD18 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RAD18 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAD18

    4 HMDB Compounds for RAD18    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    1 Novoseek chemical compound relationship for RAD18 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methylmethanesulfonate 70.2 5 10884424 (1), 12926989 (1), 15381075 (1), 17130289 (1)

    Search CenterWatch for drugs/clinical trials and news about RAD18 

    Transcripts
    for RAD18 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RAD18 gene: 
    NM_020165.3  

    Unigene Cluster for RAD18:

    RAD18 homolog (S. cerevisiae)
    Hs.375684  [show with all ESTs]
    Unigene Representative Sequence: NM_020165
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427329 ENST00000264926(uc003brd.3) ENST00000415439 ENST00000473069
    ENST00000429790 ENST00000495087 ENST00000418463 ENST00000421052 ENST00000413832
    ENST00000469793

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAD18
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate RAD18 (see all 26):
    hsa-miR-1178 hsa-miR-520e hsa-miR-302d hsa-miR-495 hsa-miR-302e hsa-miR-519a hsa-miR-570 hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmid: RAD18 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAD18 (see all 7)
    OriGene shRNA RFP: RAD18
    OriGene siRNA: RAD18
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAD18
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAD18 (see all 5)
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    GenScript: all cDNA clones in your preferred vector: RAD18 (NM_020165)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAD18
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAD18

    Additional cDNA sequence: 

    AB035274.2 AF169796.1 AK023075.1 AK123966.1 AK222771.1 AY004333.1 BC001302.1 

    7 DOTS entries:

    DT.40214779  DT.409850  DT.120880025  DT.91957136  DT.92424008  DT.95119504  DT.95251004 

    24/188 AceView cDNA sequences (see all 188):

    AL390174 AF464189 BF108779 BP374268 AI075759 BX118224 BM671019 T17310 
    BM976179 BU683286 H22584 NM_014850 AA862796 BM704301 AL515921 AA972797 
    AA729228 BQ921719 T17355 AI292169 AY004333 BM671507 AL562493 AA337772 

    GeneLoc Exon Structure


    Expression
    for RAD18 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAD18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACAAATTATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See RAD18 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAD18

    SOURCE GeneReport for Unigene cluster: Hs.375684
        SABiosciences Expression via Pathway-Focused PCR Arrays including RAD18: 
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAD18
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD18

    Orthologs
    for RAD18 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RAD18 gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rad181 , 5 RAD18 homolog (S. cerevisiae)1, 5 81.42(n)1
    74.26(a)1    		   6 (52.42 cM)5
    581861  NM_021385.21  NP_067360.21 
     1126198505 
    chicken
    (Gallus gallus)    		 Aves RAD181 RAD18 homolog (S. cerevisiae) 59.3(n)
    50.83(a)    		   416114  NM_001030603.2  NP_001025774.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RAD186
    		 --
    		 71(a)
    		 1 ↔ 1
    		 GL343273.1(1452019-1479644)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.195942 Transcribed sequence with weak similarity to protein more 79.06(n)    AL881643.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc555772 similar to RAD18 homolog (S. cerevisiae) 71.24(n)   393106  BC044430.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 33(a)
    		 1 ↔ 1
    		 Group4.13(109543-110880)
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes RAD18(YCR066W)4
    RAD181    		 E3 ubiqutin ligase, forms heterodimer with Rad6p to more4
    Rad18p1    		 42.76(n)1
    27.78(a)1    		   3(231500-232963)4
    8504301, 4  NP_009992.11, 4 


    ENSEMBL Gene Tree for RAD18 (if available)
    TreeFam Gene Tree for RAD18 (if available) 

    Paralogs
    for RAD18 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for RAD18 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1804 NCBI SNPs in RAD18 are shown (see all 1804)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs738107071,2
    		C,--8918403(+) AGTAAT/ACATAT 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs730158701,2
    		C,F,--8918409(+) CATATA/GTATGG 1 -- ds50014Minor allele frequency- G:0.04NA CSA WA 242
    rs1893502441,2
    		--8918438(+) TGATGC/TCTTCT 1 -- ds50010--------
    rs1806716481,2
    		--8918472(+) CTGGAA/TGTAAC 1 -- ds50010--------
    rs1408424521,2
    		--8918477(+) AGTAAC/TGTAAG 1 -- ds50010--------
    rs1861704161,2
    		--8918491(+) CCAAGC/TGTAGA 1 -- ds50010--------
    rs1162589171,2
    		C,F,--8918535(+) ATTGTT/CATACA 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs576778771,2
    		C,--8918558(+) TATTGT/ATAATG 1 -- ds50012Minor allele frequency- A:0.05WA 120
    rs344772521,2
    		C,--8918616(+) GTGTG-/TGAGTGT 1 -- ds50010--------
    rs1894305351,2
    		--8918752(+) ACTAGC/TATAAG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for RAD18 (8817088 - 9005457 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RAD18: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for RAD18 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RAD18 for disorders           About GeneDecksing

    OMIM gene information: 605256    OMIM disorders: --

    8 diseases for RAD18:    About MalaCards
    fanconi's anemia    werner syndrome    anemia    colorectal cancer
    lung cancer    breast cancer    esophagitis    adenocarcinoma

    2 diseases from the University of Copenhagen DISEASES database for RAD18:
    Fanconi's anemia     Werner syndrome
    Human Genome Epidemiology (HuGE) Navigator: RAD18 (6 documents)

    Export disorders for RAD18 gene to outside databases

    Publications
    for RAD18 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAD18 gene, integrated from 9 sources (see all 107):
    (articles sorted by number of sources associating them with RAD18)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens. (PubMed id 10884424)1, 2, 3, 9 Tateishi S.... Yamaizumi M. (2000)
    2. The human RAD18 gene product interacts with HHR6A and HHR6B. (PubMed id 10908344)1, 2, 3, 9 Xin H.... Wang Z. (2000)
    3. Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response. (PubMed id 22681887)1, 2 Centore R.C....Zou L. (2012)
    4. Tandem protein interaction modules organize the ubiqui tin-dependent response to DNA double-strand breaks. (PubMed id 22742833)1, 2 Panier S....Durocher D. (2012)
    5. Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination. (PubMed id 18316726)1, 2 Unk I.... Haracska L. (2008)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    7. Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen. (PubMed id 17108083)1, 2 Unk I.... Haracska L. (2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for RAD18 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RAD18 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56852 HGNC: 18278 AceView: SRGAP2andRAD18 Ensembl:ENSG00000070950 euGenes: HUgn56852
    ECgene: RAD18 H-InvDB: RAD18

    Other Databases showing RAD18 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RAD18 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAD18 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAD18 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rad18/

    Intellectual Property
    for RAD18 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RAD18 gene:
    Search GeneIP for patents involving RAD18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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