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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAD18 Gene

protein-coding   GIFtS: 60
GCID: GC03M008896

RAD18 Homolog (S. Cerevisiae)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAD18 Homolog (S. Cerevisiae)1 2     RING Finger Protein 732 3
Postreplication Repair Protein RAD182 3     E3 Ubiquitin-Protein Ligase RAD182
RNF732 3     Postreplication Repair Protein HRAD18p2
hHR182 3     RAD18, S. Cerevisiae, Homolog2
hRAD182 3     EC 6.3.2.-3

External Ids:    HGNC: 182781   Entrez Gene: 568522   Ensembl: ENSG000000709507   OMIM: 6052565   UniProtKB: Q9NS913   

Export aliases for RAD18 gene to outside databases

Previous GC identifer: GC03M008850


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAD18 Gene:
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18
functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for
post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with
the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in
defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. (provided by RefSeq, Jul 2008)

GeneCards Summary for RAD18 Gene: 
RAD18 (RAD18 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with RAD18 include werner syndrome, and fanconi's anemia, and among its related super-pathways are Cell Cycle / Checkpoint Control and Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase. GO annotations related to this gene include damaged DNA binding and ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot: RAD18_HUMAN, Q9NS91
Function: E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair
functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin
conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of
DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity

Gene Wiki entry for RAD18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAD18 gene promoter:
         GR   STAT1   FOXF2   STAT1beta   CUTL1   STAT1alpha   GATA-2   C/EBPalpha   Egr-2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAD18 promoter sequence
   Search SABiosciences Chromatin IP Primers for RAD18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAD18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25-p24   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p25-p24

RAD18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAD18 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M008896:  view genomic region     (about GC identifiers)

Start:
8,817,088 bp from pter      End:
9,005,457 bp from pter
Size:
188,370 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RAD18_HUMAN, Q9NS91 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RAD18  
Size: 495 amino acids; 56223 Da
Subunit: Interacts with UBE2A and UBE2B. Interacts with HLTF and SHPRH. Interacts with SPRTN; leading to enhance
chromatin association of RAD18 and RAD18-mediated PCNA ubiquitination and translesion DNA synthesis
Subcellular location: Nucleus (By similarity)
2 PDB 3D structures from and Proteopedia for RAD18:
2Y43 (3D)        2YBF (3D)    
Secondary accessions: Q58F55 Q9NRT6

Explore the universe of human proteins at neXtProt for RAD18: NX_Q9NS91

Explore proteomics data for RAD18 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NS91

  • RAD18 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAD18 Protein Expression
    REFSEQ proteins: NP_064550.3  
    ENSEMBL proteins: 
     ENSP00000412054   ENSP00000264926   ENSP00000402049   ENSP00000393783   ENSP00000397852  
     ENSP00000399620   ENSP00000412261  

    Human Recombinant Protein Products for RAD18: 
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    OriGene Protein Over-expression Lysate for RAD18
    OriGene MassSpec for RAD18 
    OriGene Custom Protein Services for RAD18
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    Novus Biologicals RAD18 Proteins
    Novus Biologicals RAD18 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RAD18 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IEA--
    GO:0001741XY body IEA--
    GO:0005634nucleus NAS10884424
    GO:0005657replication fork IDA18363965

    RAD18 for ontologies           About GeneDecksing



    RAD18 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RAD18
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    Cloud-Clone Corp. Antibodies for RAD18 
    ThermoFisher Antibodies for RAD18
    LSBio Antibodies in human, mouse, rat for RAD18 

    Assay Products for RAD18: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RAD18 
    Cloud-Clone Corp. CLIAs for RAD18


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    5 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR017907 Znf_RING_CS
     IPR006642 Znf_Rad18_put
     IPR003034 SAP_dom

    Graphical View of Domain Structure for InterPro Entry Q9NS91

    ProtoNet protein and cluster: Q9NS91

    3 Blocks protein domains:
    IPB001841 Zn-finger
    IPB003034 DNA-binding SAP
    IPB006642 Zn-finger Rad18


    UniProtKB/Swiss-Prot: RAD18_HUMAN, Q9NS91
    Similarity: Belongs to the RAD18 family
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 SAP domain
    Similarity: Contains 1 UBZ-type zinc finger


    RAD18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAD18_HUMAN, Q9NS91
    Function: E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair
    functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin
    conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of
    DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000403Y-form DNA binding IDA18363965
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding ----
    GO:0003684damaged DNA binding NAS10884424
    GO:0005515protein binding IPI--
         
    RAD18 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RAD18:
     Decreased cilium length after   Decreased viability with cispl  Increased cell death in HCT116 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rad18):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     reproductive system 

    RAD18 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rad18tm1Stat for RAD18

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RAD18 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RAD18

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAD18 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAD18 

    miRNA
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    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate RAD18 (see all 26):
    hsa-miR-1178 hsa-miR-520e hsa-miR-302d hsa-miR-495 hsa-miR-302e hsa-miR-519a hsa-miR-570 hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmidRAD18 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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                         Customized lentivirus expression plasmids for stable overexpression of RAD18 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD18


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAD18 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1DNA Damage
    DNA Damage0.32
    Cell Cycle / Checkpoint Control0.32
    2Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
    Common schema of ubiquitination0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RAD18
        Common schema of ubiquitination


    2 Cell Signaling Technology (CST) Pathways for RAD18
        Cell Cycle / Checkpoint Control
    DNA Damage


    UniProtKB/Swiss-Prot: RAD18_HUMAN, Q9NS91
    Pathway: Protein modification; protein ubiquitination


    RAD18 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAD18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/799 Interacting proteins for RAD18 (Q9NS912, 3 ENSP000002649264) via UniProtKB, MINT, STRING, and/or I2D (see all 799)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSG101Q998162, 3, ENSP000002519684MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000251968
    FANCIQ9NVI12, 3, ENSP000003108424MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000310842
    HLTFQ145272, 3, ENSP000003089444MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000308944
    SRRM2Q9UQ352, 3, ENSP000003017404MINT-7945693 I2D: score=1 STRING: ENSP00000301740
    NBNO609342, 3, ENSP000002654334MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000265433
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair NAS10884424
    GO:0006974response to DNA damage stimulus ----
    GO:0007283spermatogenesis IEA--
    GO:0009411response to UV IEA--
    GO:0016567protein ubiquitination IEA--

    RAD18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RAD18 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAD18

    4 HMDB Compounds for RAD18    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 Novoseek inferred chemical compound relationship for RAD18 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methylmethanesulfonate 70.2 5 10884424 (1), 12926989 (1), 15381075 (1), 17130289 (1)

    Search CenterWatch for drugs/clinical trials and news about RAD18

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAD18 gene: 
    NM_020165.3  

    Unigene Cluster for RAD18:

    RAD18 homolog (S. cerevisiae)
    Hs.375684  [show with all ESTs]
    Unigene Representative Sequence: NM_020165
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427329 ENST00000264926(uc003brd.3) ENST00000415439 ENST00000473069
    ENST00000429790 ENST00000495087 ENST00000418463 ENST00000421052 ENST00000413832
    ENST00000469793
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAD18
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate RAD18 (see all 26):
    hsa-miR-1178 hsa-miR-520e hsa-miR-302d hsa-miR-495 hsa-miR-302e hsa-miR-519a hsa-miR-570 hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmidRAD18 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD18
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAD18
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAD18

    Additional mRNA sequence: 

    AB035274.2 AF169796.1 AK023075.1 AK123966.1 AK222771.1 AY004333.1 BC001302.1 

    7 DOTS entries:

    DT.40214779  DT.409850  DT.120880025  DT.91957136  DT.92424008  DT.95119504  DT.95251004 

    24/188 AceView cDNA sequences (see all 188):

    AA729228 BM671019 BX951675 AL562493 T16436 BM704301 BQ878144 BM671507 
    AB007871 AF427144 BM976179 BC039300 CR598315 CR626625 BF108779 BU683286 
    AF464189 BP374268 AK126331 AY004333 AA337772 AL390174 AI075759 BX118224 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAD18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAAATTATA
    RAD18 Expression
    About this image


    See RAD18 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAD18

    SOURCE GeneReport for Unigene cluster: Hs.375684
        SABiosciences Expression via Pathway-Focused PCR Arrays including RAD18: 
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAD18
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RAD18 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rad181 , 5 RAD18 homolog (S. cerevisiae)1, 5 81.42(n)1
    74.26(a)1
      6 (52.42 cM)5
    581861  NM_021385.21  NP_067360.21 
     1126198505 
    chicken
    (Gallus gallus)
    Aves RAD181 RAD18 homolog (S. cerevisiae) 59.3(n)
    50.83(a)
      416114  NM_001030603.2  NP_001025774.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAD186
    Uncharacterized protein
    72(a)
    1 ↔ 1
    GL343273.1(1452019-1479644)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.195942 Transcribed sequence with weak similarity to protein more 79.06(n)    AL881643.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc555772 similar to RAD18 homolog (S. cerevisiae) 71.24(n)   393106  BC044430.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RAD18(YCR066W)4
    RAD181
    E3 ubiqutin ligase, forms heterodimer with Rad6p to more4
    Rad18p1
    42.76(n)1
    27.78(a)1
      3(231500-232963)4
    8504301, 4  NP_009992.11, 4 


    ENSEMBL Gene Tree for RAD18 (if available)
    TreeFam Gene Tree for RAD18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAD18 gene
    13 SIMAP similar genes for RAD18 using alignment to 7 protein entries:     RAD18_HUMAN (see all proteins):
    TRIM73    SH3RF3    BRCA1    TRIM37    TRIM39    TRIM35
    AMFR    LNX1    RBBP6    BMI1    CHFR    PCGF3
    TRIM3

    RAD18 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2077 SNPs in RAD18 are shown (see all 2077)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs632548611,2
    C--8874284(+) TGTGT-/GT/   
      GTGTGT
    AAAAT
    1 -- int11NA 2
    rs738107071,2
    C,F--8918403(+) AGTAAT/ACATAT 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs730158701,2
    C,F--8918409(+) CATATA/GTATGG 1 -- ds50014Minor allele frequency- G:0.04NA CSA WA 242
    rs1893502441,2
    --8918438(+) TGATGC/TCTTCT 1 -- ds50010--------
    rs1806716481,2
    --8918472(+) CTGGAA/TGTAAC 1 -- ds50010--------
    rs1408424521,2
    --8918477(+) AGTAAC/TGTAAG 1 -- ds50010--------
    rs1861704161,2
    --8918491(+) CCAAGC/TGTAGA 1 -- ds50010--------
    rs1162589171,2
    C,F--8918535(+) ATTGTT/CATACA 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs576778771,2
    C,F--8918558(+) TATTGT/ATAATG 1 -- ds50012Minor allele frequency- A:0.05WA 120
    rs344772521,2
    C--8918616(+) GTGTG-/TGAGTGT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for RAD18 (8817088 - 9005457 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RAD18:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv528867CNV Loss19592680
    nsv518352CNV Loss19592680
    dgv5106n71CNV Loss21882294
    nsv520776CNV Gain19592680
    nsv876514CNV Gain21882294
    esv275011CNV Gain+Loss21479260

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605256    OMIM disorders: --

    11 diseases for RAD18:    About MalaCards
    werner syndrome    fanconi's anemia    esophageal adenocarcinoma    anemia
    esophagitis    colorectal cancer    lung cancer    adenocarcinoma
    melanoma    hepatitis    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for RAD18:
    Fanconi's anemia     Werner syndrome

    RAD18 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RAD18
    Human Genome Epidemiology (HuGE) Navigator: RAD18 (6 documents)

    Export disorders for RAD18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAD18 gene, integrated from 9 sources (see all 118):
    (articles sorted by number of sources associating them with RAD18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens. (PubMed id 10884424)1, 2, 3, 9 Tateishi S.... Yamaizumi M. (2000)
    2. The human RAD18 gene product interacts with HHR6A and HHR6B. (PubMed id 10908344)1, 2, 3, 9 Xin H.... Wang Z. (2000)
    3. Single nucleotide polymorphism in the RAD18 gene and risk of colorectal cancer in the Japanese population. (PubMed id 17914568)1, 4, 9 Kanzaki H....Shimizu K. (2007)
    4. The association between RAD18 Arg302Gln polymorphism and the risk of human non-small-cell lung cancer. (PubMed id 17624554)1, 4, 9 Kanzaki H....Shimizu K. (2008)
    5. Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response. (PubMed id 22681887)1, 2 Centore R.C....Zou L. (2012)
    6. Tandem protein interaction modules organize the ubiqui tin-dependent response to DNA double-strand breaks. (PubMed id 22742833)1, 2 Panier S....Durocher D. (2012)
    7. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    8. Multiple genetic variants in telomere pathway genes a nd breast cancer risk. (PubMed id 20056641)1, 4 Shen J....Santella R.M. (2010)
    9. Mutation analysis of Rad18 in human cancer cell lines and non small cell lung cancer tissues. (PubMed id 19630985)1, 4 Nakamura T....Baba H. (2009)
    10. Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination. (PubMed id 18316726)1, 2 Unk I.... Haracska L. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56852 HGNC: 18278 AceView: SRGAP2andRAD18 Ensembl:ENSG00000070950 euGenes: HUgn56852
    ECgene: RAD18 H-InvDB: RAD18

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAD18 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAD18 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rad18/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAD18 gene:
    Search GeneIP for patents involving RAD18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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