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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAD17 Gene

protein-coding   GIFtS: 65
GCID: GC05P068700

RAD17 Homolog (S. Pombe)

(Previous name: RAD1 (S. pombe) homolog)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAD17 Homolog (S. Pombe)1 2     RAD242
R24L2 3     Cell Cycle Checkpoint Protein (RAD17)2
RF-C/Activator 1 Homolog2 3     Cell Cycle Checkpoint Protein RAD172
RAD1 (S. Pombe) Homolog1     RAD1 Homolog2
CCYC2     Rad17-Like Protein2
HRAD172     RF-C Activator 1 Homolog2
RAD17SP2     hRad173

External Ids:    HGNC: 98071   Entrez Gene: 58842   Ensembl: ENSG000001529427   OMIM: 6031395   UniProtKB: O759433   

Export aliases for RAD17 gene to outside databases

Previous GC identifers: GC05P068817 GC05P070230 GC05P068635 GC05P068683 GC05P068684 GC05P065621


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAD17 Gene:
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell
cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This
protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This
protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following
damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage,
which may be required for its phosphorylation. The phosphorylation of this protein is required for the
DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling
in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct
protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.
(provided by RefSeq, Jul 2013)

GeneCards Summary for RAD17 Gene: 
RAD17 (RAD17 homolog (S. pombe)) is a protein-coding gene. Diseases associated with RAD17 include testis seminoma, and seminoma, and among its related super-pathways are G2/M Checkpoints and Cell Cycle / Checkpoint Control. GO annotations related to this gene include nucleoside-triphosphatase activity and ATP binding.

UniProtKB/Swiss-Prot: RAD17_HUMAN, O75943
Function: Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint
activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the
recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a
sensor of DNA replication progression, and may be involved in homologous recombination

Gene Wiki entry for RAD17 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006713.15  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAD17 gene promoter:
         ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): RAD17 promoter sequence
   Search SABiosciences Chromatin IP Primers for RAD17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAD17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13   Ensembl cytogenetic band:  5q13.2   HGNC cytogenetic band: 5q13

RAD17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAD17 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P068700:  view genomic region     (about GC identifiers)

Start:
68,665,120 bp from pter      End:
68,710,628 bp from pter
Size:
45,509 bases      Orientation:
plus strand

1 alternative location:
Chr5+,NW_003315917.2 152,493-198,224     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RAD17_HUMAN, O75943 (See protein sequence)
Recommended Name: Cell cycle checkpoint protein RAD17  
Size: 681 amino acids; 77055 Da
Subunit: Part of a DNA-binding complex containing RFC2, RFC3, RFC4 and RFC5. Interacts with RAD1 and RAD9 within
the RAD1-RAD9-HUS1 complex. Interacts with RAD9B, POLE, NHP2L1 and MCM7. DNA damage promotes interaction with ATR
or ATM and disrupts interaction with the RAD1-RAD9-HUS1 complex
Subcellular location: Nucleus. Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage
Secondary accessions: A8K8X2 D3DWA5 O75714 Q7Z3S4 Q9UNK7 Q9UNR7 Q9UNR8 Q9UPF5
Alternative splicing: 4 isoforms:  O75943-1   O75943-2   O75943-3   O75943-4   

Explore the universe of human proteins at neXtProt for RAD17: NX_O75943

Explore proteomics data for RAD17 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Phosphorylation on Ser-646 and Ser-656 is cell cycle-regulated, enhanced by genotoxic stress, and
    required for activation of checkpoint signaling. Phosphorylation is mediated by ATR upon UV or replication
    arrest, whereas it may be mediated both by ATR and ATM upon ionizing radiation. Phosphorylation on both sites is
    required for interaction with RAD1 but dispensable for interaction with RFC3 or RFC4
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75943

  • RAD17 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAD17 Protein Expression
    REFSEQ proteins (9 alternative transcripts): 
    NP_001265551.1  NP_002864.1  NP_579916.1  NP_579917.1  NP_579918.1  NP_579919.1  NP_579920.1  NP_579921.1  
    NP_579922.1  

    ENSEMBL proteins: 
     ENSP00000355226   ENSP00000423060   ENSP00000426191   ENSP00000346938   ENSP00000427743  
     ENSP00000346271   ENSP00000311227   ENSP00000427673   ENSP00000424696   ENSP00000303134  
     ENSP00000282891   ENSP00000370151   ENSP00000424289   ENSP00000425005   ENSP00000350725  
    Reactome Protein details: O75943
    Human Recombinant Protein Products for RAD17: 
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RAD17
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for RAD17
    GenScript Custom Purified and Recombinant Proteins Services for RAD17
    Novus Biologicals RAD17 Proteins
    Novus Biologicals RAD17 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RAD17 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000781colocalizes with chromosome, telomeric region IDA15149599
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    RAD17 for ontologies           About GeneDecksing



    RAD17 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RAD17
    R&D Systems Antibodies for RAD17
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    Novus Biologicals RAD17 Antibodies
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    ThermoFisher Antibodies for RAD17
    LSBio Antibodies in human, mouse, rat for RAD17 

    Assay Products for RAD17: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems Proteome Profiler Antibody Arrays for RAD17
    GenScript Custom Assay Services for RAD17
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RAD17 
    Cloud-Clone Corp. CLIAs for RAD17


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR004582 Checkpoint_prot_Rad17_Rad24
     IPR018324 Checkpoint_prot_Rad24_fun/met
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry O75943

    ProtoNet protein and cluster: O75943

    UniProtKB/Swiss-Prot: RAD17_HUMAN, O75943
    Similarity: Belongs to the rad17/RAD24 family


    RAD17 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAD17_HUMAN, O75943
    Function: Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint
    activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the
    recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a
    sensor of DNA replication progression, and may be involved in homologous recombination
    Induction: Isoform 1, isoform 3 and isoform 4 are induced by X-ray irradiation

         Genatlas biochemistry entry for RAD17:
    cell cycle G2 checkpoint control gene,homologous to S.pombe,RAD17 S cerevisiae RAD24,with two alternatively
    spliced isoforms,highly expressed in the testis,seminone and cancer cell lines (in colon carcinoma),interacting
    with RAD1(interaction protein-protein in the cell cycle checkpoint machinery),required for S-phase and G2/M
    arrest in response to DNA damage or incomplete DNA replication,expressed in testis and seminoma

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10884395
    GO:0005524ATP binding IEA--
    GO:0009378four-way junction helicase activity ----
    GO:0017111nucleoside-triphosphatase activity IEA--
         
    RAD17 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RAD17:
     Decreased POU5F1-GFP protein e  Increased cell number in G1, a  Upregulation of Wnt/beta-caten 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rad17):
     cardiovascular system  craniofacial  embryogenesis  liver/biliary system  mortality/aging 
     nervous system 

    RAD17 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rad17tm1Maas for RAD17

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RAD17 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RAD17

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAD17 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAD17 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAD17
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate RAD17 (see all 12):
    hsa-miR-3910 hsa-miR-3200-5p hsa-miR-205 hsa-miR-4251 hsa-miR-130a* hsa-miR-23c hsa-miR-181a-2* hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidRAD17 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of RAD17

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 8): RAD17 (NM_133338)
    Sino Biological Human cDNA Clone for RAD17
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAD17
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD17
    Sirion Biotech Customized lentivirus for stable overexpression of RAD17 
                         Customized lentivirus expression plasmids for stable overexpression of RAD17 

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    Search LifeMap BioReagents cell lines for RAD17
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD17


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAD17 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Activation of ATR in response to replication stress
    G2/M Checkpoints0.86
    Activation of ATR in response to replication stress0.86
    2DNA Damage
    DNA Damage0.32
    Cell Cycle / Checkpoint Control0.32
    3Chks in Checkpoint Regulation
    Chks in Checkpoint Regulation0.59
    DNA Repair Mechanisms0.32
    4Cell Cycle
    Cell Cycle0.84
    5CDK-mediated phosphorylation and removal of Cdc6
    Cell Cycle Checkpoints0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RAD17
        DNA Repair Mechanisms
    Chks in Checkpoint Regulation
    DNA Damage Induced 14-3-3Sigma Signaling

    2 Cell Signaling Technology (CST) Pathways for RAD17
        Cell Cycle / Checkpoint Control
    DNA Damage

    2 BioSystems Pathways for RAD17
        DNA damage response
    Gastric cancer network 2


    4        Reactome Pathways for RAD17
        Activation of ATR in response to replication stress
    Cell Cycle
    G2/M Checkpoints
    Cell Cycle Checkpoints



    RAD17 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAD17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/53 Interacting proteins for RAD17 (O759432, 3 ENSP000003701514) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FZR1Q9UM112, 3, ENSP000003785294MINT-7897581 MINT-7897592 I2D: score=1 STRING: ENSP00000378529
    RAD9AQ996382, 3, ENSP000003113604MINT-7897390 I2D: score=4 STRING: ENSP00000311360
    NHP2L1P557693, ENSP000002159564I2D: score=3 STRING: ENSP00000215956
    HUS1O609213, ENSP000002587744I2D: score=2 STRING: ENSP00000258774
    RAD1O606713, ENSP000003408794I2D: score=2 STRING: ENSP00000340879
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000076DNA replication checkpoint TAS9660800
    GO:0000077DNA damage checkpoint IMP15538388
    GO:0006260DNA replication TAS--
    GO:0006281DNA repair IEA--
    GO:0006310DNA recombination ----

    RAD17 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RAD17 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAD17

    3 Novoseek inferred chemical compound relationships for RAD17 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydroxyurea 32.6 1 14643437 (1)
    serine 8.06 2 11687627 (1), 18160429 (1)
    atp 0 1 15014082 (1)

    Search CenterWatch for drugs/clinical trials and news about RAD17

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAD17 gene (9 alternative transcripts): 
    NM_001278622.1  NM_002873.1  NM_133338.2  NM_133339.2  NM_133340.2  NM_133341.2  NM_133342.2  NM_133343.1  
    NM_133344.2  

    Unigene Cluster for RAD17:

    RAD17 homolog (S. pombe)
    Hs.16184  [show with all ESTs]
    Unigene Representative Sequence: AF076838
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000514066 ENST00000361732(uc003jwg.3) ENST00000507927 ENST00000509734(uc003jwk.3)
    ENST00000354868(uc003jwi.3 uc003jwh.3 uc003jwj.3 uc003jwo.3)
    ENST00000511349 ENST00000521422 ENST00000504177 ENST00000354312(uc003jwm.3 uc003jwn.3)
    ENST00000345306 ENST00000512785 ENST00000506564 ENST00000305138(uc003jwl.3)
    ENST00000282891 ENST00000380774 ENST00000514626 ENST00000508320 ENST00000513214

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    hsa-miR-3910 hsa-miR-3200-5p hsa-miR-205 hsa-miR-4251 hsa-miR-130a* hsa-miR-23c hsa-miR-181a-2* hsa-miR-124
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF017748.1 AF076838.1 AF085736.2 AF098533.1 AF098534.1 AF112263.1 AF126424.1 AJ001642.1 
    AJ004977.1 AK292487.1 AL122068.1 BC018110.1 BC032304.1 BX537441.1 

    19 DOTS entries:

    DT.70103909  DT.100801079  DT.100038394  DT.92430414  DT.443071  DT.120842356  DT.95318963  DT.100038397 
    DT.419165  DT.120842183  DT.100795141  DT.120842298  DT.120842400  DT.95273035  DT.100703220  DT.120762147 
    DT.120842191  DT.75171598  DT.92430405 

    24/182 AceView cDNA sequences (see all 182):

    BG179669 AJ001642 BC032304 NM_133339 BM310142 AF076838 NM_133342 AI095669 
    AA749322 NM_133338 AA811328 AA872592 BM834026 AI381926 CR625205 AW273075 
    AI357149 AL522325 CB306991 AA678412 BU618742 BC018110 BG260641 BX537441 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RAD17 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
    SP1:                    -                                                                                         -                                             
    SP2:                                                                                                              -                                             
    SP3:                                            -                                                                 -                                             
    SP4:                                      -                                                                       -                                             
    SP5:                                                                                                                                                            

    ExUns: 20b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for RAD17

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAD17 expression in normal human tissues (normalized intensities)      RAD17 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGAAAACA
    RAD17 Expression
    About this image


    RAD17 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             testis ; cells in seminiferus ducts   
             sperm   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             cd4+ cells   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             bronchus ; respiratory epithelial cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; squamous epithelial cells   

    See RAD17 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAD17

    SOURCE GeneReport for Unigene cluster: Hs.16184

    UniProtKB/Swiss-Prot: RAD17_HUMAN, O75943
    Tissue specificity: Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform
    2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level). Ubiquitous at low
    levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous
    tubuli. Weakly expressed in seminomas (testicular tumors)

        SABiosciences Expression via Pathway-Focused PCR Arrays including RAD17: 
              Cell Cycle in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Telomeres & Telomerase in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAD17 gene from 10/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rad171 , 5 RAD17 homolog (S. pombe)1, 5 84.09(n)1
    82.03(a)1
      13 (53.23 cM)5
    193561  NM_001044371.11  NP_001037836.11 
     1006171655 
    chicken
    (Gallus gallus)
    Aves RAD171 RAD17 homolog (S. pombe) 66.17(n)
    59.52(a)
      404778  NM_213584.2  NP_998749.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAD176
    RAD17 homolog (S. pombe)
    53(a)
    1 ↔ 1
    2(17037777-17059478)
    African clawed frog
    (Xenopus laevis)
    Amphibia AY169965.12   -- 73.69(n)    AY169965.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rad171 RAD17 homolog (S. pombe) 59.56(n)
    53.83(a)
      436934  NM_001002661.1  NP_001002661.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rad171 , 3 DNA repair3
    CG7825-PA1
    33(a)3
    43.96(n)1
    34.29(a)1
      88C103
    417791  NM_142125.31  NP_650382.31 
    worm
    (Caenorhabditis elegans)
    Secernentea hpr-176
    Protein HPR-17
    26(a)
    1 ↔ 1
    II(13153461-13157047)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RAD24(YER173W)4 Checkpoint protein, involved in the activation of the more   --   5(536300-538279) 856920  NP_011100.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATRAD171 cell cycle checkpoint protein RAD17 44.61(n)
    32.6(a)
      836745  NM_126011.1  NP_201414.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g02421001 hypothetical protein 44.88(n)
    29.48(a)
      4332216  NM_001056056.2  NP_001049521.2 


    ENSEMBL Gene Tree for RAD17 (if available)
    TreeFam Gene Tree for RAD17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAD17 gene

    RAD17 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RAD17
    PGOHUM00000248396 PGOHUM00000250853


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1002 SNPs in RAD17 are shown (see all 1002)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs718244801,2
    C--65651701(+) TAACG-/GTT/
            
    TGTTG
    16 -- int1 cds10--------
    rs131553641,2
    H--65652224(+) TAGGGT/Gttatt 8 -- int14Minor allele frequency- G:0.00NS EA 408
    rs38572781,2
    C--65652254(+) tattt-/ATT/
     TTTATTT
    tAttt
    16 -- int1 cds11NA 2
    rs1855568141,2
    --68583265(+) ACGTGG/TGGTGG 3 -- us2k10--------
    rs1880113001,2
    --68583274(+) GGCTCC/GCGCGT 3 -- us2k10--------
    rs1457105661,2
    --68583336(+) AGTTCC/GAGACC 3 -- us2k10--------
    rs1808693511,2
    C--68583525(+) GCATGC/TAAATG 3 -- us2k10--------
    rs68590391,2
    H--68583543(+) ATGTAC/TATACT 3 -- us2k14Minor allele frequency- T:0.00NS EA 364
    rs780390681,2
    C--68583549(-) TAACA-/AAGAGTA 3 -- us2k10--------
    rs1997301581,2
    C--68583550(+) TACTC-/TTTGTTA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAD17 (68665120 - 68710628 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RAD17:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1308626CNV Insertion17803354
    nsv881767CNV Loss21882294
    nsv881768CNV Loss21882294
    nsv821643CNV Loss15273396
    nsv428117CNV Gain+Loss18775914

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603139    OMIM disorders: --

    11 diseases for RAD17:    About MalaCards
    testis seminoma    seminoma    ataxia telangiectasia    nijmegen breakage syndrome
    bloom syndrome    sporadic breast cancer    ataxia    hypoxia
    breast cancer    lung cancer    leukemia


    RAD17 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for RAD17 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ataxia telangiectasia 62.7 1 16452194 (1)
    carcinoma non-small cell lung 41.9 1 11606373 (1)
    chromosomal aberrations 22 1 12672690 (1)
    immunodeficiency 10.5 1 16968670 (1)
    cancer 2.98 2 11555598 (1)
    tumors 2.83 2 11555598 (1), 11606373 (1)
    cancer lung 0 1 11606373 (1)

    Genetic Association Database (GAD): RAD17
    Human Genome Epidemiology (HuGE) Navigator: RAD17 (3 documents)

    Export disorders for RAD17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAD17 gene, integrated from 9 sources (see all 97):
    (articles sorted by number of sources associating them with RAD17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint gene. (PubMed id 9660800)1, 2, 3 Parker A.E....Luyten W.H.M.L. (1998)
    2. The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9. (PubMed id 10884395)1, 2, 9 Rauen M.... Karnitz L.M. (2000)
    3. Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage. (PubMed id 11687627)1, 2, 9 Post S.M.... Lee E.Y.-H.P. (2001)
    4. Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. (PubMed id 15538388)1, 2, 9 Tsao C.-C.... Abraham R.T. (2004)
    5. Genomic instability and endoreduplication triggered by RAD17 deletion. (PubMed id 12672690)1, 2, 9 Wang X.... Li L. (2003)
    6. cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster. (PubMed id 9878245)1, 2, 9 Dean F.B.... O'Donnell M. (1998)
    7. ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. (PubMed id 11418864)1, 2, 9 Bao S.... Wang X.-F. (2001)
    8. Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene. (PubMed id 9933569)1, 2, 9 Bluyssen H.A.R.... de Klein A. (1999)
    9. HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation. (PubMed id 10593953)1, 2, 9 Chang M.-S....Chen L.B. (1999)
    10. Human and mouse RAD17 genes: identification, localization, genomic structure and histological expression pattern in normal testis and seminoma. (PubMed id 10480350)1, 2, 9 von Deimling F.... Wirth B. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5884 HGNC: 9807 AceView: RAD17 Ensembl:ENSG00000152942 euGenes: HUgn5884
    ECgene: RAD17 H-InvDB: RAD17

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAD17 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAD17 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rad17/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAD17 gene:
    Search GeneIP for patents involving RAD17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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