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Aliases for RAD17 Gene

Aliases for RAD17 Gene

  • RAD17 Checkpoint Clamp Loader Component 2 3 5
  • HRAD17 3 4
  • R24L 3 4
  • Cell Cycle Checkpoint Protein (RAD17) 3
  • Cell Cycle Checkpoint Protein RAD17 3
  • RAD17 Homolog (S. Pombe) 2
  • RF-C Activator 1 Homolog 3
  • RF-C/Activator 1 Homolog 4
  • RAD1 (S. Pombe) Homolog 2
  • Rad17-Like Protein 3
  • RAD17 Homolog 3
  • RAD1 Homolog 3
  • RAD17SP 3
  • RAD24 3
  • CCYC 3

External Ids for RAD17 Gene

Previous GeneCards Identifiers for RAD17 Gene

  • GC05P068817
  • GC05P070230
  • GC05P068635
  • GC05P068683
  • GC05P068684
  • GC05P068700
  • GC05P065621

Summaries for RAD17 Gene

Entrez Gene Summary for RAD17 Gene

  • The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013]

GeneCards Summary for RAD17 Gene

RAD17 (RAD17 Checkpoint Clamp Loader Component) is a Protein Coding gene. Diseases associated with RAD17 include Seminoma and Ataxia-Telangiectasia. Among its related pathways are DNA Damage and DNA Double-Strand Break Repair. GO annotations related to this gene include four-way junction helicase activity and DNA clamp loader activity.

UniProtKB/Swiss-Prot for RAD17 Gene

  • Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.

Gene Wiki entry for RAD17 Gene

Additional gene information for RAD17 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAD17 Gene

Genomics for RAD17 Gene

Regulatory Elements for RAD17 Gene

Enhancers for RAD17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H069516 1.6 Ensembl ENCODE dbSUPER 17 +150.0 150002 5 PKNOX1 FOXA2 ARNT FEZF1 ZNF2 ZNF302 FOS SP3 REST ZNF592 GTF2H2C ENSG00000198237 ENSG00000254701 GUSBP3 ENSG00000253333 CDH12P2 SLC30A5 RAD17 LOC728499 ENSG00000251158
GH05H069449 1.4 Ensembl ENCODE dbSUPER 14.9 +83.6 83565 6 HDAC1 ELF3 FOXA2 ARID4B RAD21 RARA YY1 FOS CREM MIXL1 OCLN CCDC125 RAD17 LOC101928924 MARVELD2 GTF2H2C ENSG00000250138 ENSG00000198237 SMN2 GC05M069454
GH05H069367 1.4 Ensembl ENCODE 9.5 +0.6 558 5 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 GTF2H2C CCDC125 RAD17 OCLN TAF9 AK6
GH05H069275 0.8 ENCODE 13.9 -92.3 -92306 2 ELF3 SOX13 FOXA2 SAP130 ARID4B CEBPG ZNF384 RARA TEAD3 ZNF121 CDK7 CCDC125 RAD17 CCNB1 GC05P069259 GC05P069260 CFL1P5
GH05H069166 1.1 ENCODE 7.1 -201.9 -201881 2 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 FOS SP3 CCDC125 GTF2H2C RAD17 CCNB1 PIR41528
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAD17 on UCSC Golden Path with GeneCards custom track

Promoters for RAD17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000182016 307 2801 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 SLC30A9

Transcription factor binding sites by QIAGEN in the RAD17 gene promoter:

Genomic Location for RAD17 Gene

Chromosome:
5
Start:
69,369,293 bp from pter
End:
69,414,801 bp from pter
Size:
45,509 bases
Orientation:
Plus strand

Genomic View for RAD17 Gene

Genes around RAD17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAD17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAD17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAD17 Gene

Proteins for RAD17 Gene

  • Protein details for RAD17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75943-RAD17_HUMAN
    Recommended name:
    Cell cycle checkpoint protein RAD17
    Protein Accession:
    O75943
    Secondary Accessions:
    • A8K8X2
    • D3DWA5
    • O75714
    • Q7Z3S4
    • Q9UNK7
    • Q9UNR7
    • Q9UNR8
    • Q9UPF5

    Protein attributes for RAD17 Gene

    Size:
    681 amino acids
    Molecular mass:
    77055 Da
    Quaternary structure:
    • Part of a DNA-binding complex containing RFC2, RFC3, RFC4 and RFC5. Interacts with RAD1 and RAD9 within the RAD1-RAD9-HUS1 complex. Interacts with RAD9B, POLE, SNU13 and MCM7. DNA damage promotes interaction with ATR or ATM and disrupts interaction with the RAD1-RAD9-HUS1 complex.

    Alternative splice isoforms for RAD17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAD17 Gene

Post-translational modifications for RAD17 Gene

  • Phosphorylated. Phosphorylation on Ser-646 and Ser-656 is cell cycle-regulated, enhanced by genotoxic stress, and required for activation of checkpoint signaling. Phosphorylation is mediated by ATR upon UV or replication arrest, whereas it may be mediated both by ATR and ATM upon ionizing radiation. Phosphorylation on both sites is required for interaction with RAD1 but dispensable for interaction with RFC3 or RFC4.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RAD17 (RAD17)
  • Abcam antibodies for RAD17
  • Santa Cruz Biotechnology (SCBT) Antibodies for RAD17

No data available for DME Specific Peptides for RAD17 Gene

Domains & Families for RAD17 Gene

Gene Families for RAD17 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAD17 Gene

Suggested Antigen Peptide Sequences for RAD17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75943

UniProtKB/Swiss-Prot:

RAD17_HUMAN :
  • Belongs to the rad17/RAD24 family.
Family:
  • Belongs to the rad17/RAD24 family.
genes like me logo Genes that share domains with RAD17: view

Function for RAD17 Gene

Molecular function for RAD17 Gene

GENATLAS Biochemistry:
cell cycle G2 checkpoint control gene,homologous to S.pombe,RAD17 S cerevisiae RAD24,with two alternatively spliced isoforms,highly expressed in the testis,seminone and cancer cell lines (in colon carcinoma),interacting with RAD1(interaction protein-protein in the cell cycle checkpoint machinery),required for S-phase and G2/M arrest in response to DNA damage or incomplete DNA replication,expressed in testis and seminoma
UniProtKB/Swiss-Prot Function:
Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.
UniProtKB/Swiss-Prot Induction:
Isoform 1, isoform 3 and isoform 4 are induced by X-ray irradiation.

Phenotypes From GWAS Catalog for RAD17 Gene

Gene Ontology (GO) - Molecular Function for RAD17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003682 chromatin binding IBA --
GO:0003689 contributes_to DNA clamp loader activity IBA --
GO:0005515 protein binding IPI 10593953
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with RAD17: view
genes like me logo Genes that share phenotypes with RAD17: view

Animal Models for RAD17 Gene

MGI Knock Outs for RAD17:

Animal Model Products

CRISPR Products

miRNA for RAD17 Gene

miRTarBase miRNAs that target RAD17

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RAD17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAD17 Gene

Localization for RAD17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAD17 Gene

Nucleus. Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAD17 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RAD17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 colocalizes_with chromosome, telomeric region IDA 15149599
GO:0000790 nuclear chromatin IBA --
GO:0005634 nucleus TAS 9660800
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 10593953
genes like me logo Genes that share ontologies with RAD17: view

Pathways & Interactions for RAD17 Gene

genes like me logo Genes that share pathways with RAD17: view

Pathways by source for RAD17 Gene

SIGNOR curated interactions for RAD17 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for RAD17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000076 DNA replication checkpoint TAS 9660800
GO:0000077 DNA damage checkpoint IMP 15538388
GO:0006260 DNA replication TAS --
GO:0006281 DNA repair IBA --
GO:0006974 cellular response to DNA damage stimulus IMP 15538388
genes like me logo Genes that share ontologies with RAD17: view

Drugs & Compounds for RAD17 Gene

(3) Drugs for RAD17 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RAD17: view

Transcripts for RAD17 Gene

Unigene Clusters for RAD17 Gene

RAD17 homolog (S. pombe):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RAD17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RAD17 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
SP1: - -
SP2: -
SP3: - -
SP4: - -
SP5:
SP6: - - -
SP7: - - - - - - - - - - - - - - - - - - - -

ExUns: 20b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for RAD17 Gene

GeneLoc Exon Structure for
RAD17
ECgene alternative splicing isoforms for
RAD17

Expression for RAD17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAD17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAD17 Gene

This gene is overexpressed in CD4 Tcells (44.0) and Retina (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAD17 Gene



Protein tissue co-expression partners for RAD17 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAD17 Gene:

RAD17

SOURCE GeneReport for Unigene cluster for RAD17 Gene:

Hs.16184

mRNA Expression by UniProt/SwissProt for RAD17 Gene:

O75943-RAD17_HUMAN
Tissue specificity: Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform 2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level). Ubiquitous at low levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli. Weakly expressed in seminomas (testicular tumors).

Evidence on tissue expression from TISSUES for RAD17 Gene

  • Nervous system(4.4)
  • Intestine(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with RAD17: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAD17 Gene

Orthologs for RAD17 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAD17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAD17 33 34
  • 99.41 (n)
cow
(Bos Taurus)
Mammalia RAD17 33 34
  • 91.32 (n)
dog
(Canis familiaris)
Mammalia RAD17 33 34
  • 90.89 (n)
mouse
(Mus musculus)
Mammalia Rad17 33 16 34
  • 84.09 (n)
rat
(Rattus norvegicus)
Mammalia Rad17 33
  • 83.53 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 81 (a)
OneToMany
-- 34
  • 72 (a)
OneToMany
-- 34
  • 41 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RAD17 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAD17 33 34
  • 66.42 (n)
lizard
(Anolis carolinensis)
Reptilia RAD17 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rad17 33
  • 63.13 (n)
zebrafish
(Danio rerio)
Actinopterygii rad17 33 34
  • 60.17 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rad17 35 33 34
  • 46.29 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008673 33
  • 41.77 (n)
worm
(Caenorhabditis elegans)
Secernentea hpr-17 34
  • 27 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD24 34 36 36 36 36 36 36
  • 19 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons ATRAD17 33
  • 44.55 (n)
rice
(Oryza sativa)
Liliopsida Os03g0242100 33
  • 45.24 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
OneToMany
-- 34
  • 36 (a)
OneToMany
Species where no ortholog for RAD17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAD17 Gene

ENSEMBL:
Gene Tree for RAD17 (if available)
TreeFam:
Gene Tree for RAD17 (if available)

Paralogs for RAD17 Gene

Pseudogenes.org Pseudogenes for RAD17 Gene

genes like me logo Genes that share paralogs with RAD17: view

No data available for Paralogs for RAD17 Gene

Variants for RAD17 Gene

Sequence variations from dbSNP and Humsavar for RAD17 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1019920610 -- 69,404,770(+) GTTTC(A/C)AAAAA intron-variant
rs1045051 --
rs11340448 -- 69,389,580(+) TGTTC(-/A)ATAAA intron-variant
rs138054935 -- 69,371,437(+) TTCTT(-/CCC)CCCCC intron-variant, upstream-variant-2KB
rs142095225 -- 69,400,208(+) TAGGG(-/TTTATTTA)TTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAD17 Gene

Variant ID Type Subtype PubMed ID
dgv5694n100 CNV gain 25217958
esv1308626 CNV insertion 17803354
nsv428117 CNV gain+loss 18775914
nsv821643 CNV loss 15273396

Variation tolerance for RAD17 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.47; 92.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAD17 Gene

Human Gene Mutation Database (HGMD)
RAD17
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAD17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAD17 Gene

Disorders for RAD17 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RAD17 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
seminoma
  • seminoma, pure
ataxia-telangiectasia
  • ataxia telangiectasia
- elite association - COSMIC cancer census association via MalaCards
Search RAD17 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RAD17

Genetic Association Database (GAD)
RAD17
Human Genome Epidemiology (HuGE) Navigator
RAD17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAD17
genes like me logo Genes that share disorders with RAD17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAD17 Gene

Publications for RAD17 Gene

  1. Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. (PMID: 15538388) Tsao CC … Abraham RT (The EMBO journal 2004) 3 4 22 60
  2. Genomic instability and endoreduplication triggered by RAD17 deletion. (PMID: 12672690) Wang X … Li L (Genes & development 2003) 3 4 22 60
  3. ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. (PMID: 11418864) Bao S … Wang XF (Nature 2001) 3 4 22 60
  4. Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage. (PMID: 11687627) Post S … Lee EY (Proceedings of the National Academy of Sciences of the United States of America 2001) 3 4 22 60
  5. The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9. (PMID: 10884395) Rauen M … Karnitz LM (The Journal of biological chemistry 2000) 3 4 22 60

Products for RAD17 Gene

Sources for RAD17 Gene

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