RAD17 Gene
protein-coding GIFtS: 64
GCID: GC05P068700
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RAD17 homolog (S. pombe)(Previous name: RAD1 (S. pombe) homolog )
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Aliases
for RAD17 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RAD17 Homolog (S. Pombe)1 2 | | RAD17SP2 | | CCYC1 2 | | RAD242 | | R24L2 3 | | Cell Cycle Checkpoint Protein (RAD17)2 | | RF-C/Activator 1 Homolog2 3 | | Cell Cycle Checkpoint Protein RAD172 | | RAD17Sp1 | | RAD1 Homolog2 | | Rad241 | | Rad17-Like Protein2 | | RAD1 (S. Pombe) Homolog1 | | RF-C Activator 1 Homolog2 | | HRAD172 | | HRad171 |
Export aliases for RAD17 gene to outside databasesPrevious GC identifers: GC05P068817 GC05P070230 GC05P068635 GC05P068683 GC05P068684 GC05P065621 |
Summaries
for RAD17 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RAD17:
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cyclecheckpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein sharesstrong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds tochromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This proteinrecruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for itsphosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, andis thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively splicedtranscript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located onchromosomes 7 and 13, have been identified. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RAD17_HUMAN, O75943Function: Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpointactivation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in therecruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as asensor of DNA replication progression, and may be involved in homologous recombination
Gene Wiki entry for RAD17
|
Genomic Views
for RAD17 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006713.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAD17 gene promoter:
ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAD17
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAD17 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q13 Ensembl cytogenetic band: 5q13.2 HGNC cytogenetic band: 5q13RAD17 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P068700: view genomic region
(about GC identifiers)
Start:
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68,665,120 bp from pter |
End:
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68,710,628 bp from pter |
Size:
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45,509 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr5+,PATCHES 69,057,486-69,103,217 |
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Proteins
for RAD17 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RAD17_HUMAN, O75943 (See
protein sequence)Recommended Name: Cell cycle checkpoint protein RAD17 Size: 681 amino acids; 77055 Da
Subunit: Part of a DNA-binding complex containing RFC2, RFC3, RFC4 and RFC5. Interacts with RAD1 and RAD9 within theRAD1-RAD9-HUS1 complex. Interacts with RAD9B, POLE, NHP2L1 and MCM7. DNA damage promotes interaction with ATR or ATMand disrupts interaction with the RAD1-RAD9-HUS1 complex
Subcellular location: Nucleus. Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage
Secondary accessions: A8K8X2 D3DWA5 O75714 Q7Z3S4 Q9UNK7 Q9UNR7 Q9UNR8 Q9UPF5Alternative splicing: 4 isoforms: O75943-1 O75943-2 O75943-3 O75943-4 Explore the universe of human proteins at neXtProt for RAD17: NX_O75943
Post-translational modifications:
Phosphorylated. Phosphorylation on Ser-646 and Ser-656 is cell cycle-regulated, enhanced by genotoxic stress, andrequired for activation of checkpoint signaling. Phosphorylation is mediated by ATR upon UV or replication arrest,whereas it may be mediated both by ATR and ATM upon ionizing radiation. Phosphorylation on both sites is required forinteraction with RAD1 but dispensable for interaction with RFC3 or RFC41
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75943
RAD17 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (8 alternative transcripts):
NP_002864.1 NP_579916.1 NP_579917.1 NP_579918.1 NP_579919.1 NP_579920.1 NP_579921.1 NP_579922.1
ENSEMBL proteins: ENSP00000355226 ENSP00000423060 ENSP00000426191 ENSP00000346938 ENSP00000427743 ENSP00000346271 ENSP00000311227 ENSP00000427673 ENSP00000424696 ENSP00000303134 ENSP00000282891 ENSP00000370151 ENSP00000424289 ENSP00000425005 ENSP00000350725 Reactome Protein details: O75943
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
RAD17 for ontologies About GeneDecksing
RAD17 Antibody Products:
Assay Products for RAD17: |
Protein
Domains /
Families
for RAD17 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAD17 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75943ProtoNet protein and cluster: O75943 UniProtKB/Swiss-Prot: RAD17_HUMAN, O75943Similarity: Belongs to the rad17/RAD24 family |
Function
for RAD17 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RAD17_HUMAN, O75943Function: Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpointactivation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in therecruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as asensor of DNA replication progression, and may be involved in homologous recombinationInduction: Isoform 1, isoform 3 and isoform 4 are induced by X-ray irradiation Genatlas biochemistry entry for RAD17:cell cycle G2 checkpoint control gene,homologous to S.pombe,RAD17 S cerevisiae RAD24,with two alternatively splicedisoforms,highly expressed in the testis,seminone and cancer cell lines (in colon carcinoma),interacting withRAD1(interaction protein-protein in the cell cycle checkpoint machinery),required for S-phase and G2/M arrest inresponse to DNA damage or incomplete DNA replication,expressed in testis and seminoma
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAD17 (see all 10)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAD17 (see all 9)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 8): RAD17 (NM_133338) | |  | Sino Biological Human cDNA Clone for RAD17 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAD17 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD17 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD17 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
RAD17 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for RAD17:
Animal Models:
Mouse knock-out Rad17tm1Maas for RAD17
6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Rad17):
RAD17 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RAD17 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Activation of ATR in response to replication stress | | | 2 | Chks in Checkpoint Regulation | | | 3 | Cell Cycle / Checkpoint Control | | | 4 | Cell Cycle | | | 5 | DNA Damage Induced 14-3-3Sigma Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RAD17
1 
Cell Signaling Technology (CST) Pathway for RAD17
1  BioSystems Pathway for RAD17
4 
Reactome Pathways for RAD17
RAD17 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAD17
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/53 Interacting proteins for RAD17 (O759432, 3 ENSP000003701514) via UniProtKB, MINT, STRING, and/or I2D (see all 53)About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
RAD17 for ontologies About GeneDecksing
|
Drugs & Compounds
for RAD17 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RAD17 for compounds About GeneDecksing
 Browse Tocris compounds for RAD17
3 Novoseek chemical compound relationships for RAD17 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hydroxyurea |
32.6 |
1 |
14643437 (1) |
| serine |
8.06 |
2 |
11687627 (1), 18160429 (1) |
| atp |
0 |
1 |
15014082 (1) |
Search CenterWatch for drugs/clinical trials and news about RAD17
|
Transcripts
for RAD17 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RAD17 gene (8 alternative transcripts): NM_002873.1 NM_133338.1 NM_133339.1 NM_133340.1 NM_133341.1 NM_133342.1 NM_133343.1 NM_133344.1 Unigene Cluster for RAD17: RAD17 homolog (S. pombe) Hs.16184 [show with all ESTs]Unigene Representative Sequence: AF07683818/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19): ENST00000514066 ENST00000361732(uc003jwg.3) ENST00000507927 ENST00000509734(uc003jwk.3)
ENST00000354868(uc003jwi.3 uc003jwh.3 uc003jwj.3 uc003jwo.3)
ENST00000511349 ENST00000521422 ENST00000504177 ENST00000354312(uc003jwm.3 uc003jwn.3)
ENST00000345306 ENST00000512785 ENST00000506564 ENST00000305138(uc003jwl.3)
ENST00000282891 ENST00000380774 ENST00000514626 ENST00000508320 ENST00000513214
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAD17 (see all 10)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAD17 (see all 9)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 8): RAD17 (NM_133338) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAD17 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD17 |
Additional cDNA sequence: AF017748.1 AF076838.1 AF085736.2 AF098533.1 AF098534.1 AF112263.1 AF126424.1 AJ001642.1 AJ004977.1 AK292487.1 AL122068.1 BC018110.1 BC032304.1 BX537441.1 19 DOTS entries: DT.70103909 DT.100801079 DT.100038394 DT.92430414 DT.443071 DT.120842356 DT.95318963 DT.100038397 DT.419165 DT.120842183 DT.100795141 DT.120842298 DT.120842400 DT.95273035 DT.100703220 DT.120762147 DT.120842191 DT.75171598 DT.92430405 24/182 AceView cDNA sequences (see all 182): AI351438 AI367228 AI381926 BM462198 AA811328 AA678412 AI378934 CB243255 AJ001642 AA721033 AI824387 AL555702 CB306991 AI095669 NM_133341 AA749322 BI907388 BM979093 AL522325 BC018110 BM471331 NM_002873 BM995093 AJ004977
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RAD17 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20a | · |
|---|
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| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20b |
|---|
|
| SP1: | | | |
| SP2: | | | |
| SP3: | | | |
| SP4: | | | |
| SP5: | | |
ECgene alternative splicing isoforms for RAD17
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Expression
for RAD17 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RAD17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAGAAAACA
About this image
See RAD17 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAD17
SOURCE GeneReport for Unigene cluster: Hs.16184
UniProtKB/Swiss-Prot: RAD17_HUMAN, O75943Tissue specificity: Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform 2 andisoform 3 are the most abundant isoforms in non irradiated cells (at protein level). Ubiquitous at low levels. Highlyexpressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli. Weakly expressedin seminomas (testicular tumors)
SABiosciences Expression via Pathway-Focused PCR Arrays including RAD17:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAD17
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAD17 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAD17 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAD17 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD17 |
Orthologs
for RAD17 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RAD17 gene from 9/27 species (see all 27) About this table
ENSEMBL Gene Tree for RAD17 (if available)
TreeFam Gene Tree for RAD17 (if available) |
Paralogs
for RAD17 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RAD17 gene
1 SIMAP similar gene for RAD17 using alignment to 10 protein entries: RAD17_HUMAN (see all proteins):RFC4
RAD17 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for RAD17
PGOHUM00000248396 PGOHUM00000250853
|
Genomic Variants
for RAD17 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RAD17 (68665120 - 68710628 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RAD17
1 CNV: 0283 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAD17 |
|
Disorders
/ Diseases
for RAD17 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RAD17 for disorders About GeneDecksing
OMIM gene information: 603139
OMIM disorders: --
14  diseases for RAD17: About MalaCardsnijmegen breakage syndrome testis seminoma ataxia telangiectasia sporadic breast cancer
bloom syndrome seminoma ataxia breast cancer
colon carcinoma immunodeficiency lung cancer carcinoma
hypoxia leukemia
7 Novoseek disease relationships for RAD17 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ataxia telangiectasia |
62.7 |
1 |
16452194 (1) |
| carcinoma non-small cell lung |
41.9 |
1 |
11606373 (1) |
| chromosomal aberrations |
22 |
1 |
12672690 (1) |
| immunodeficiency |
10.5 |
1 |
16968670 (1) |
| cancer |
2.98 |
2 |
11555598 (1) |
| tumors |
2.83 |
2 |
11555598 (1), 11606373 (1) |
| cancer lung |
0 |
1 |
11606373 (1) |
Human Genome Epidemiology (HuGE) Navigator: RAD17 (3 documents)
Export disorders for RAD17 gene to outside databases
|
Publications
for RAD17 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RAD17 gene, integrated from 9 sources (see all 93):
(articles sorted by number of sources associating them with RAD17) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint gene. (PubMed id 9660800)1, 2, 3 Parker A.E....Luyten W.H.M.L. (1998)
- The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9. (PubMed id 10884395)1, 2, 9 Rauen M.... Karnitz L.M. (2000)
- Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage. (PubMed id 11687627)1, 2, 9 Post S.M.... Lee E.Y.-H.P. (2001)
- Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. (PubMed id 15538388)1, 2, 9 Tsao C.-C.... Abraham R.T. (2004)
- Genomic instability and endoreduplication triggered by RAD17 deletion. (PubMed id 12672690)1, 2, 9 Wang X.... Li L. (2003)
- cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster. (PubMed id 9878245)1, 2, 9 Dean F.B.... O'Donnell M. (1998)
- ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. (PubMed id 11418864)1, 2, 9 Bao S.... Wang X.-F. (2001)
- Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene. (PubMed id 9933569)1, 2, 9 Bluyssen H.A.R.... de Klein A. (1999)
- HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation. (PubMed id 10593953)1, 2, 9 Chang M.-S....Chen L.B. (1999)
- Human and mouse RAD17 genes: identification, localization, genomic structure and histological expression pattern in normal testis and seminoma. (PubMed id 10480350)1, 2, 9 von Deimling F.... Wirth B. (1999)
|
External Searches for RAD17 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RAD17 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RAD17 gene
(According to HUGE)
About This Section
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Specialized Databases showing RAD17 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for RAD17 gene:
Search GeneIP for patents involving RAD17
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RAD17 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for RAD17 | | OriGene shRNA RFP for RAD17 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAD17 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAD17 | | | OriGene Protein Over-expression Lysate for RAD17 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RAD17 | | OriGene 3'-UTR Clone for RAD17 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAD17 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAD17 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RAD17 | | OriGene Custom Protein Services for RAD17 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAD17 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAD17 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAD17 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAD17 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAD17 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAD17 |
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| | Antibodies & Assays for RAD17 |
| | | | Search Tocris compounds for RAD17 |
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 | | | RAD17 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD17 |
|  |  |  | | | | ThermoFisher Antibodies for RAD17 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD17 |
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