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RAD17 Gene

protein-coding   GIFtS: 64
GCID: GC05P068700

RAD17 Homolog (S. Pombe)

(Previous name: RAD1 (S. pombe) homolog)
  Search for RAD17
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAD17 Homolog (S. Pombe)1 2     RAD242
R24L2 3     Cell Cycle Checkpoint Protein (RAD17)2
RF-C/Activator 1 Homolog2 3     Cell Cycle Checkpoint Protein RAD172
RAD1 (S. Pombe) Homolog1     RAD1 Homolog2
CCYC2     Rad17-Like Protein2
HRAD172     RF-C Activator 1 Homolog2
RAD17SP2     hRad173

External Ids:    HGNC: 98071   Entrez Gene: 58842   Ensembl: ENSG000001529427   OMIM: 6031395   UniProtKB: O759433   

Export aliases for RAD17 gene to outside databases

Previous GC identifers: GC05P068817 GC05P070230 GC05P068635 GC05P068683 GC05P068684 GC05P065621


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAD17 Gene:
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell
cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This
protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This
protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following
damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage,
which may be required for its phosphorylation. The phosphorylation of this protein is required for the
DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling
in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct
protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.
(provided by RefSeq, Jul 2013)

GeneCards Summary for RAD17 Gene:
RAD17 (RAD17 homolog (S. pombe)) is a protein-coding gene. GO annotations related to this gene include nucleoside-triphosphatase activity.

UniProtKB/Swiss-Prot: RAD17_HUMAN, O75943
Function: Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint
activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the
recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a
sensor of DNA replication progression, and may be involved in homologous recombination

Gene Wiki entry for RAD17 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAD17 gene promoter:
         ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): RAD17 promoter sequence
   Search Chromatin IP Primers for RAD17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAD17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13   Ensembl cytogenetic band:  5q13.2   HGNC cytogenetic band: 5q13

RAD17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAD17 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P068700:  view genomic region     (about GC identifiers)

Start:
68,665,120 bp from pter      End:
68,710,628 bp from pter
Size:
45,509 bases      Orientation:
plus strand

1 alternative location:
Chr5+,NW_003315917.2 152,493-198,224     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RAD17_HUMAN, O75943 (See protein sequence)
Recommended Name: Cell cycle checkpoint protein RAD17  
Size: 681 amino acids; 77055 Da
Subunit: Part of a DNA-binding complex containing RFC2, RFC3, RFC4 and RFC5. Interacts with RAD1 and RAD9 within
the RAD1-RAD9-HUS1 complex. Interacts with RAD9B, POLE, NHP2L1 and MCM7. DNA damage promotes interaction with ATR
or ATM and disrupts interaction with the RAD1-RAD9-HUS1 complex
Secondary accessions: A8K8X2 D3DWA5 O75714 Q7Z3S4 Q9UNK7 Q9UNR7 Q9UNR8 Q9UPF5
Alternative splicing: 4 isoforms:  O75943-1   O75943-2   O75943-3   O75943-4   

Explore the universe of human proteins at neXtProt for RAD17: NX_O75943

Explore proteomics data for RAD17 at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation on Ser-646 and Ser-656 is cell cycle-regulated, enhanced by genotoxic stress, and
    required for activation of checkpoint signaling. Phosphorylation is mediated by ATR upon UV or replication
    arrest, whereas it may be mediated both by ATR and ATM upon ionizing radiation. Phosphorylation on both sites is
    required for interaction with RAD1 but dispensable for interaction with RFC3 or RFC41
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RAD17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (9 alternative transcripts): 
    NP_001265551.1  NP_002864.1  NP_579916.1  NP_579917.1  NP_579918.1  NP_579919.1  NP_579920.1  NP_579921.1  
    NP_579922.1  

    ENSEMBL proteins: 
     ENSP00000355226   ENSP00000423060   ENSP00000426191   ENSP00000346938   ENSP00000427743  
     ENSP00000346271   ENSP00000311227   ENSP00000427673   ENSP00000424696   ENSP00000303134  
     ENSP00000282891   ENSP00000370151   ENSP00000424289   ENSP00000425005   ENSP00000350725  
    Reactome Protein details: O75943

    RAD17 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for RAD17
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    Novus Biologicals RAD17 Proteins
    Novus Biologicals RAD17 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RAD17

     
    Search eBioscience for Proteins for RAD17 

    RAD17 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for RAD17
    Cell Signaling Technology (CST) Antibodies for RAD17 
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    LSBio Antibodies in human, mouse, rat for RAD17

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    Search eBioscience for ELISAs for RAD17 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR004582 Checkpoint_prot_Rad17_Rad24
     IPR018324 Checkpoint_prot_Rad24_fun/met
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry O75943

    ProtoNet protein and cluster: O75943

    UniProtKB/Swiss-Prot: RAD17_HUMAN, O75943
    Similarity: Belongs to the rad17/RAD24 family


    Find genes that share domains with RAD17           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAD17_HUMAN, O75943
    Function: Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint
    activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the
    recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a
    sensor of DNA replication progression, and may be involved in homologous recombination
    Induction: Isoform 1, isoform 3 and isoform 4 are induced by X-ray irradiation

         Genatlas biochemistry entry for RAD17:
    cell cycle G2 checkpoint control gene,homologous to S.pombe,RAD17 S cerevisiae RAD24,with two alternatively
    spliced isoforms,highly expressed in the testis,seminone and cancer cell lines (in colon carcinoma),interacting
    with RAD1(interaction protein-protein in the cell cycle checkpoint machinery),required for S-phase and G2/M
    arrest in response to DNA damage or incomplete DNA replication,expressed in testis and seminoma

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10884395
    GO:0005524ATP binding IEA--
    GO:0009378four-way junction helicase activity ----
    GO:0017111nucleoside-triphosphatase activity IEA--
         
    Find genes that share ontologies with RAD17           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for RAD17:
     Decreased POU5F1-GFP protein e  Increased cell number in G1, a  Upregulation of Wnt/beta-caten 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rad17):
     cardiovascular system  craniofacial  embryogenesis  liver/biliary system  mortality/aging 
     nervous system 

    Find genes that share phenotypes with RAD17           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rad17tm1Maas for RAD17

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAD17
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RAD17

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAD17
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAD17

    miRNA
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    Block miRNA regulation of human, mouse, rat RAD17 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAD17 (see all 12):
    hsa-miR-3910 hsa-miR-3200-5p hsa-miR-205 hsa-miR-4251 hsa-miR-130a* hsa-miR-23c hsa-miR-181a-2* hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidRAD17 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat RAD17

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for RAD17
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    GenScript: all cDNA clones in your preferred vector (see all 8): RAD17 (NM_133338)
    Sino Biological Human cDNA Clone for RAD17
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAD17
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD17

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for RAD17 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD17


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RAD17_HUMAN, O75943: Nucleus. Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000781colocalizes with chromosome, telomeric region IDA15149599
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with RAD17           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAD17 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1G2/M Checkpoints
    G2/M Checkpoints0.84
    Activation of ATR in response to replication stress0.84
    2Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    DNA Damage0.32
    3Chks in Checkpoint Regulation
    Chks in Checkpoint Regulation0.59
    DNA Repair Mechanisms0.32
    4Cell Cycle, Mitotic
    Cell Cycle0.90
    5CDK-mediated phosphorylation and removal of Cdc6
    Cell Cycle Checkpoints0.58


    Find genes that share SuperPaths with RAD17           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RAD17
        DNA Repair Mechanisms
    Chks in Checkpoint Regulation
    DNA Damage Induced 14-3-3Sigma Signaling

    2 Cell Signaling Technology (CST) Pathways for RAD17
        Cell Cycle / Checkpoint Control
    DNA Damage

    2 BioSystems Pathways for RAD17
        DNA damage response
    Gastric cancer network 2


    1 Reactome Pathway for RAD17
        Activation of ATR in response to replication stress


        Pathway & Disease-focused RT2 Profiler PCR Arrays including RAD17: 
              Cell Cycle in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Telomeres & Telomerase in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RAD17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAD17 (O759431, 2, 3 ENSP000003701514) via UniProtKB, MINT, STRING, and/or I2D (see all 230)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAD9AQ996382, 3, ENSP000003113604MINT-7897390 I2D: score=4 STRING: ENSP00000311360
    FZR1Q9UM111, 2, 3, ENSP000003785294EBI-968231,EBI-724997 MINT-7897581 MINT-7897592 I2D: score=1 STRING: ENSP00000378529
    ATMQ133153, ENSP000002786164I2D: score=4 STRING: ENSP00000278616
    POLEQ078643, ENSP000003225704I2D: score=3 STRING: ENSP00000322570
    HUS1O609213, ENSP000002587744I2D: score=2 STRING: ENSP00000258774
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000076DNA replication checkpoint TAS9660800
    GO:0000077DNA damage checkpoint IMP15538388
    GO:0006260DNA replication TAS--
    GO:0006281DNA repair IEA--
    GO:0006310DNA recombination ----

    Find genes that share ontologies with RAD17           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAD17

    3 Novoseek inferred chemical compound relationships for RAD17 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydroxyurea 32.6 1 14643437 (1)
    serine 8.06 2 11687627 (1), 18160429 (1)
    atp 0 1 15014082 (1)



    Find genes that share compounds with RAD17           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RAD17 gene (9 alternative transcripts): 
    NM_001278622.1  NM_002873.1  NM_133338.2  NM_133339.2  NM_133340.2  NM_133341.2  NM_133342.2  NM_133343.1  
    NM_133344.2  

    Unigene Cluster for RAD17:

    RAD17 homolog (S. pombe)
    Hs.16184  [show with all ESTs]
    Unigene Representative Sequence: AF076838
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000514066 ENST00000361732(uc003jwg.3) ENST00000507927 ENST00000509734(uc003jwk.3)
    ENST00000354868(uc003jwi.3 uc003jwh.3 uc003jwj.3 uc003jwo.3)
    ENST00000511349 ENST00000521422 ENST00000504177 ENST00000354312(uc003jwm.3 uc003jwn.3)
    ENST00000345306 ENST00000512785 ENST00000506564 ENST00000305138(uc003jwl.3)
    ENST00000282891 ENST00000380774 ENST00000514626 ENST00000508320 ENST00000513214

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RAD17 (see all 12):
    hsa-miR-3910 hsa-miR-3200-5p hsa-miR-205 hsa-miR-4251 hsa-miR-130a* hsa-miR-23c hsa-miR-181a-2* hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidRAD17 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RAD17
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 8): RAD17 (NM_133338)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD17
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAD17
      QuantiTect SYBR Green Assays in human, mouse, rat RAD17
      QuantiFast Probe-based Assays in human, mouse, rat RAD17

    Additional mRNA sequence: 

    AF017748.1 AF076838.1 AF085736.2 AF098533.1 AF098534.1 AF112263.1 AF126424.1 AJ001642.1 
    AJ004977.1 AK292487.1 AL122068.1 BC018110.1 BC032304.1 BX537441.1 

    19 DOTS entries:

    DT.70103909  DT.100801079  DT.100038394  DT.92430414  DT.443071  DT.120842356  DT.95318963  DT.100038397 
    DT.419165  DT.120842183  DT.100795141  DT.120842298  DT.120842400  DT.95273035  DT.100703220  DT.120762147 
    DT.120842191  DT.75171598  DT.92430405 

    Selected AceView cDNA sequences (see all 182):

    BC018110 AA864882 AA548869 BX100903 AL522325 BM309861 BM995093 BF514687 
    AF076838 AA811328 AA721033 AI378934 AJ004977 NM_133339 BM310142 AW273075 
    CR608057 BM462198 CD636174 BM462221 NM_133340 NM_133341 BQ416939 CR625205 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RAD17 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
    SP1:                    -                                                                                         -                                             
    SP2:                                                                                                              -                                             
    SP3:                                            -                                                                 -                                             
    SP4:                                      -                                                                       -                                             
    SP5:                                                                                                                                                            

    ExUns: 20b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for RAD17

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAD17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGAAAACA
    RAD17 Expression
    About this image


    RAD17 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
    RAD17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAD17 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.16184

    UniProtKB/Swiss-Prot: RAD17_HUMAN, O75943
    Tissue specificity: Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform
    2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level). Ubiquitous at low
    levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous
    tubuli. Weakly expressed in seminomas (testicular tumors)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAD17 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rad171 , 5 RAD17 homolog (S. pombe)1, 5 84.09(n)1
    82.03(a)1
      13 (53.23 cM)5
    193561  NM_001044371.21  NP_001037836.11 
     1006171655 
    chicken
    (Gallus gallus)
    Aves RAD171 RAD17 homolog (S. pombe) 66.42(n)
    59.82(a)
      404778  NM_213584.2  NP_998749.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAD176
    RAD17 homolog (S. pombe)
    54(a)
    1 ↔ 1
    2(17037777-17059478)
    African clawed frog
    (Xenopus laevis)
    Amphibia AY169965.12   -- 73.69(n)    AY169965.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rad171 RAD17 homolog (S. pombe) 60.17(n)
    54.14(a)
      436934  NM_001002661.1  NP_001002661.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rad171 , 3 DNA repair3
    Rad171
    33(a)3
    46.29(n)1
    37.53(a)1
      88C103
    417791  NM_142125.31  NP_650382.31 
    worm
    (Caenorhabditis elegans)
    Secernentea hpr-176
    Protein HPR-17 (hpr-17) mRNA, complete cds
    27(a)
    1 ↔ 1
    II(13153461-13157047) WBGene00001998
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RAD24(YER173W)4 Checkpoint protein, involved in the activation of the more   --   5(536300-538279) 856920  NP_011100.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATRAD171 ATRAD17 44.55(n)
    32.24(a)
      836745  NM_126011.1  NP_201414.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g02421001 Os03g0242100 45.24(n)
    30.54(a)
      4332216  NM_001056056.2  NP_001049521.2 


    ENSEMBL Gene Tree for RAD17 (if available)
    TreeFam Gene Tree for RAD17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAD17 gene

    Find genes that share paralogs with RAD17           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for RAD17
    PGOHUM00000248396 PGOHUM00000250853


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAD17 (see all 1002)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs718244801,2
    C--65651701(+) TAACG-/GTT/
            
    TGTTG
    16 -- int1 cds10--------
    rs131553641,2
    H--65652224(+) TAGGGT/Gttatt 8 -- int14Minor allele frequency- G:0.00NS EA 408
    rs38572781,2
    C--65652254(+) tattt-/ATT/
     TTTATTT
    tAttt
    16 -- int1 cds11NA 2
    rs1855568141,2
    --68583265(+) ACGTGG/TGGTGG 3 -- us2k10--------
    rs1880113001,2
    --68583274(+) GGCTCC/GCGCGT 3 -- us2k10--------
    rs1457105661,2
    --68583336(+) AGTTCC/GAGACC 3 -- us2k10--------
    rs1808693511,2
    C--68583525(+) GCATGC/TAAATG 3 -- us2k10--------
    rs68590391,2
    H--68583543(+) ATGTAC/TATACT 3 -- us2k14Minor allele frequency- T:0.00NS EA 364
    rs780390681,2
    C--68583549(-) TAACA-/AAGAGTA 3 -- us2k10--------
    rs1997301581,2
    C--68583550(+) TACTC-/TTTGTTA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAD17 (68665120 - 68710628 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RAD17:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1308626CNV Insertion17803354
    nsv881767CNV Loss21882294
    nsv881768CNV Loss21882294
    nsv821643CNV Loss15273396
    nsv428117CNV Gain+Loss18775914

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603139    OMIM disorders: --


    Find genes that share disorders with RAD17           About GenesLikeMe

    7 Novoseek inferred disease relationships for RAD17 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ataxia telangiectasia 62.7 1 16452194 (1)
    carcinoma non-small cell lung 41.9 1 11606373 (1)
    chromosomal aberrations 22 1 12672690 (1)
    immunodeficiency 10.5 1 16968670 (1)
    cancer 2.98 2 11555598 (1)
    tumors 2.83 2 11555598 (1), 11606373 (1)
    cancer lung 0 1 11606373 (1)

    Genetic Association Database (GAD): RAD17
    Human Genome Epidemiology (HuGE) Navigator: RAD17 (3 documents)

    Export disorders for RAD17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAD17 gene, integrated from 10 sources (see all 99):
    (articles sorted by number of sources associating them with RAD17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint gene. (PubMed id 9660800)1, 2, 3 Parker A.E....Luyten W.H.M.L. (J. Biol. Chem. 1998)
    2. The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9. (PubMed id 10884395)1, 2, 9 Rauen M.... Karnitz L.M. (J. Biol. Chem. 2000)
    3. Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage. (PubMed id 11687627)1, 2, 9 Post S.M.... Lee E.Y.-H.P. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    4. Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. (PubMed id 15538388)1, 2, 9 Tsao C.-C.... Abraham R.T. (EMBO J. 2004)
    5. Genomic instability and endoreduplication triggered by RAD17 deletion. (PubMed id 12672690)1, 2, 9 Wang X.... Li L. (Genes Dev. 2003)
    6. cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster. (PubMed id 9878245)1, 2, 9 Dean F.B.... O'Donnell M. (Genomics 1998)
    7. ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. (PubMed id 11418864)1, 2, 9 Bao S.... Wang X.-F. (Nature 2001)
    8. Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene. (PubMed id 9933569)1, 2, 9 Bluyssen H.A.R.... de Klein A. (Genomics 1999)
    9. HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation. (PubMed id 10593953)1, 2, 9 Chang M.-S....Chen L.B. (J. Biol. Chem. 1999)
    10. Human and mouse RAD17 genes: identification, localization, genomic structure and histological expression pattern in normal testis and seminoma. (PubMed id 10480350)1, 2, 9 von Deimling F.... Wirth B. (Hum. Genet. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5884 HGNC: 9807 AceView: RAD17 Ensembl:ENSG00000152942 euGenes: HUgn5884
    ECgene: RAD17 H-InvDB: RAD17

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RAD17 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAD17 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rad17/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAD17 gene:
    Search GeneIP for patents involving RAD17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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