Aliases for RAD17 Gene
External Ids for RAD17 Gene
Previous GeneCards Identifiers for RAD17 Gene
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013]
GeneCards Summary for RAD17 Gene
RAD17 (RAD17 Checkpoint Clamp Loader Component) is a Protein Coding gene. Diseases associated with RAD17 include Seminoma and Ataxia-Telangiectasia. Among its related pathways are DNA Damage Induced 14-3-3Sigma Signaling and E2F mediated regulation of DNA replication. GO annotations related to this gene include four-way junction helicase activity and DNA clamp loader activity.
UniProtKB/Swiss-Prot for RAD17 Gene
Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.