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RAD1 Gene

protein-coding   GIFtS: 63
GCID: GC05M034905

RAD1 Homolog (S. Pombe)

(Previous name: RAD1 (S. pombe) homolog)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAD1 Homolog (S. Pombe)1 2     DNA Repair Exonuclease Rad1 Homolog2 3
Cell Cycle Checkpoint Protein Hrad11 2     RAD1 (S. Pombe) Homolog1
Checkpoint Control Protein HRAD11 2     Rad1-Like DNA Damage Checkpoint1
DNA Repair Exonuclease REC11 2     HRAD12
Exonuclease Homolog RAD11 2     Cell Cycle Checkpoint Protein RAD12
Rad1-Like DNA Damage Checkpoint Protein2 3     EC 3.1.11.23
REC12 3     hRAD13

External Ids:    HGNC: 98061   Entrez Gene: 58102   Ensembl: ENSG000001134567   OMIM: 6031535   UniProtKB: O606713   

Export aliases for RAD1 gene to outside databases

Previous GC identifers: GC05M034941 GC05M035934 GC05M034953 GC05M034944 GC05M034854


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAD1 Gene:
This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that
is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1
complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA
repair effectors. Alternatively spliced transcript variants of this gene have been described. (provided by
RefSeq, Jan 2009)

GeneCards Summary for RAD1 Gene:
RAD1 (RAD1 homolog (S. pombe)) is a protein-coding gene. GO annotations related to this gene include damaged DNA binding and exodeoxyribonuclease III activity.

UniProtKB/Swiss-Prot: RAD1_HUMAN, O60671
Function: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The
9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader
complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision
repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for
the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1
cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase
I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of
RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. Isoform 1 possesses 3'->5' double
stranded DNA exonuclease activity

Gene Wiki entry for RAD1 (RAD1 homolog) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_006576.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAD1 gene promoter:
         GR   GR-alpha   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RAD1 promoter sequence
   Search Chromatin IP Primers for RAD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.2   Ensembl cytogenetic band:  5p13.2   HGNC cytogenetic band: 5p13

RAD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAD1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M034905:  view genomic region     (about GC identifiers)

Start:
34,905,365 bp from pter      End:
34,919,094 bp from pter
Size:
13,730 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RAD1_HUMAN, O60671 (See protein sequence)
Recommended Name: Cell cycle checkpoint protein RAD1  
Size: 282 amino acids; 31827 Da
Subunit: Component of the toroidal 9-1-1 (RAD9-RAD1-HUS1) complex, composed of RAD9A, RAD1 and HUS1. The 9-1-1
complex associates with LIG1, POLB, FEN1, RAD17, HDAC1, RPA1 and RPA2. The 9-1-1 complex associates with the
RAD17-RFC complex. RAD1 interacts with POLB, FEN1, HUS1, HUS1B, RAD9A and RAD9B. Interacts with DNAJC7
Sequence caution: Sequence=AAC35550.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAC35550.1; Type=Frameshift; Positions=103; Sequence=CAA06249.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=CAA06249.1; Type=Frameshift; Positions=103;
3 PDB 3D structures from and Proteopedia for RAD1:
3A1J (3D)        3G65 (3D)        3GGR (3D)    
Secondary accessions: O75572 O95304 Q1W161 Q5KSM0 Q5KSM1 Q9UEP1
Alternative splicing: 3 isoforms:  O60671-1   O60671-2   O60671-3   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for RAD1: NX_O60671

Explore proteomics data for RAD1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys46
  • Modification sites at PhosphoSitePlus

  • See RAD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002844.1  
    ENSEMBL proteins: 
     ENSP00000371469   ENSP00000340879   ENSP00000313467   ENSP00000421007   ENSP00000423253  
    Reactome Protein details: O60671

    RAD1 Human Recombinant Protein Products:

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    Novus Biologicals RAD1 Proteins
    Novus Biologicals RAD1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for RAD1
    Cloud-Clone Corp. Proteins for RAD1

     
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    antibodies-online proteins for RAD1 (14 products) 

     
    antibodies-online peptides for RAD1

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    antibodies-online antibodies for RAD1 (44 products) 

    RAD1 Assay Products:

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    Cloud-Clone Corp. ELISAs for RAD1
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    antibodies-online kits for RAD1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR003011 Cell_cycle_checkpoint_Rad1
     IPR003021 Rad1_Rec1_Rad17

    Graphical View of Domain Structure for InterPro Entry O60671

    ProtoNet protein and cluster: O60671

    2 Blocks protein domains:
    IPB003011 Rad1 repair protein signature
    IPB003021 Repair protein Rad1/Rec1 family signature


    UniProtKB/Swiss-Prot: RAD1_HUMAN, O60671
    Similarity: Belongs to the rad1 family


    Find genes that share domains with RAD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAD1_HUMAN, O60671
    Function: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The
    9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader
    complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision
    repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for
    the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1
    cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase
    I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of
    RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. Isoform 1 possesses 3'->5' double
    stranded DNA exonuclease activity
    Catalytic activity: Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates

         Genatlas biochemistry entry for RAD1:
    cell cycle G2 checkpoint control gene,also involved in DNA repair,homologous to RAD17,S pombe
    Rad1,S.cerevisiae,with two alternatively spliced isoforms (large RAD1-b and short RAD1-c),ubiquitously
    expressed,may be involved in lung carcinoma

         Enzyme Number (IUBMB): EC 3.1.11.21

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003684damaged DNA binding NAS9660799
    GO:0005515protein binding IPI10359610
    GO:00084083'-5' exonuclease activity IDA9660799
    GO:0008853exodeoxyribonuclease III activity IEA--
         
    Find genes that share ontologies with RAD1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RAD1:
     Upregulation of Wnt/beta-caten 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rad1):
     immune system 

    Find genes that share phenotypes with RAD1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAD1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RAD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAD1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAD1

    miRNA
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    miRTarBase miRNAs that target RAD1:
    hsa-mir-192-5p (MIRT026379), hsa-mir-215-5p (MIRT024409), hsa-mir-155-5p (MIRT020681), hsa-mir-943 (MIRT036556)

    Block miRNA regulation of human, mouse, rat RAD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAD1 (see all 14):
    hsa-miR-577 hsa-miR-582-3p hsa-miR-576-5p hsa-miR-376b hsa-miR-944 hsa-miR-551b* hsa-miR-4260 hsa-miR-376a
    SwitchGear 3'UTR luciferase reporter plasmidRAD1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RAD1
    Predesigned siRNA for gene silencing in human, mouse, rat RAD1

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for RAD1
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    GenScript: all cDNA clones in your preferred vector: RAD1 (NM_002853)
    Sino Biological Human cDNA Clone for RAD1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RAD1_HUMAN, O60671: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    cytosol1
    extracellular1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with RAD1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAD1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1G2/M Checkpoints
    G2/M Checkpoints0.84
    Activation of ATR in response to replication stress0.84
    2Chks in Checkpoint Regulation
    Chks in Checkpoint Regulation0.59
    DNA Repair Mechanisms0.32
    3Cell Cycle, Mitotic
    Cell Cycle0.90
    4CDK-mediated phosphorylation and removal of Cdc6
    Cell Cycle Checkpoints0.58
    5p53 signaling pathway
    DNA damage response0.41


    Find genes that share SuperPaths with RAD1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RAD1
        DNA Repair Mechanisms
    Chks in Checkpoint Regulation
    DNA Damage Induced 14-3-3Sigma Signaling

    2 BioSystems Pathways for RAD1
        DNA damage response
    Regulation of Telomerase


    1 Reactome Pathway for RAD1
        Activation of ATR in response to replication stress


        Pathway & Disease-focused RT2 Profiler PCR Arrays including RAD1: 
              Cell Cycle in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RAD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAD1 (O606711, 2, 3 ENSP000003408794) via UniProtKB, MINT, STRING, and/or I2D (see all 228)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HUS1O609211, 3, ENSP000002587744EBI-721835,EBI-1056174 I2D: score=3 STRING: ENSP00000258774
    RAD9AQ996381, 3, ENSP000003113604EBI-721835,EBI-2606224 I2D: score=2 STRING: ENSP00000311360
    MAP1LC3BQ9GZQ82, 3MINT-65697 I2D: score=3 
    CALRP277973, ENSP000003208664I2D: score=1 STRING: ENSP00000320866
    P4HBP072373, ENSP000003278014I2D: score=1 STRING: ENSP00000327801
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint NAS9660799
    GO:0000077DNA damage checkpoint IMP--
    GO:0006260DNA replication TAS--
    GO:0006281DNA repair IEA--
    GO:0006974cellular response to DNA damage stimulus TAS9872989

    Find genes that share ontologies with RAD1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAD1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RAD1 gene (4 alternative transcripts): 
    NM_002853.3  NM_001033673.1  NM_133282.1  NM_133377.2  

    Unigene Cluster for RAD1:

    RAD1 homolog (S. pombe)
    Hs.38114  [show with all ESTs]
    Unigene Representative Sequence: NM_002853
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382038(uc003jiw.3 uc003jix.3 uc003jiy.3) ENST00000341754
    ENST00000325577 ENST00000513914 ENST00000511456 ENST00000512192 ENST00000506311

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    Selected qRT-PCR Assays for microRNAs that regulate RAD1 (see all 14):
    hsa-miR-577 hsa-miR-582-3p hsa-miR-576-5p hsa-miR-376b hsa-miR-944 hsa-miR-551b* hsa-miR-4260 hsa-miR-376a
    SwitchGear 3'UTR luciferase reporter plasmidRAD1 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: RAD1 (NM_002853)
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    Primer
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    OriGene qPCR primer pairs and template standards for RAD1
    OriGene qSTAR qPCR primer pairs in human, mouse for RAD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAD1
      QuantiTect SYBR Green Assays in human, mouse, rat RAD1
      QuantiFast Probe-based Assays in human, mouse, rat RAD1

    Additional mRNA sequence: 

    AF011905.1 AF030933.1 AF058392.1 AF058393.1 AF073524.1 AF074717.1 AF076841.1 AF084512.1 
    AF084513.1 AF090170.1 AJ004974.1 AJ004975.1 AK002112.1 AK096960.1 AK125316.1 BC006837.1 
    BC009804.1 BC035771.1 BC037857.1 BT006908.1 NR_026591.1 

    18 DOTS entries:

    DT.444475  DT.100024236  DT.309747  DT.97841332  DT.100033743  DT.99972608  DT.100798519  DT.100798520 
    DT.120802598  DT.75103106  DT.75114249  DT.92435047  DT.97764608  DT.100728535  DT.120802596  DT.425390 
    DT.92044223  DT.92430524 

    Selected AceView cDNA sequences (see all 213):

    D79907 BG108349 BQ027826 AI564938 CF527867 AF058392 AI474618 AI245063 
    CN482823 BC037857 AF090170 BE906787 AU123712 BC009804 AF058393 BM453151 
    AA029300 BM802547 BU682777 AI699844 BX439078 AA525955 BX479175 AF076841 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RAD1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
    SP1:                    -     -                                             
    SP2:                                                                        
    SP3:              -     -     -     -     -                                 
    SP4:                    -     -     -                                       
    SP5:                                                                        


    ECgene alternative splicing isoforms for RAD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATAAATG
    RAD1 Expression
    About this image

    RAD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.38114

    UniProtKB/Swiss-Prot: RAD1_HUMAN, O60671
    Tissue specificity: Expressed in testis, uterus, bladder, spleen, ovaries, lung, brain and muscle (at protein
    level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RAD1: 
              Cell Cycle in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for RAD1
    OriGene qSTAR qPCR primer pairs in human, mouse for RAD1
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    QuantiFast Probe-based Assays in human, mouse, rat RAD1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RAD1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rad11 , 5 RAD1 homolog (S. pombe)1, 5 87.26(n)1
    90.71(a)1
      15 (5.35 cM)5
    193551  NM_011232.21  NP_035362.21 
     104860185 
    chicken
    (Gallus gallus)
    Aves RAD11 RAD1 homolog (S. pombe) 75.24(n)
    83.21(a)
      427432  XM_004937180.1  XP_004937237.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAD16
    RAD1 homolog (S. pombe)
    88(a)
    1 ↔ 1
    GL343241.1(2044878-2052437)
    African clawed frog
    (Xenopus laevis)
    Amphibia Rad12 checkpoint protein 77.12(n)    AY253233.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc777792 hypothetical protein MGC77779 76.09(n)   393872  BC049464.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rad11 Radiation insensitive 1 44.36(n)
    31.47(a)
      33440  NM_058092.4  NP_477440.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mrt-21 mrt-2 45.43(n)
    29.84(a)
      176608  NM_067120.4  NP_499521.1 


    ENSEMBL Gene Tree for RAD1 (if available)
    TreeFam Gene Tree for RAD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAD1 gene

    Find genes that share paralogs with RAD1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for RAD1
    PGOHUM00000238938 PGOHUM00000244302


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAD1 (see all 217)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1449015061,2
    --34904945(+) AGGGTC/TTACTA 2 -- ds50010--------
    rs1387440651,2
    --34904967(+) CCTTTC/TTACTT 2 -- ds50010--------
    rs350697391,2
    --34905158(+) AGATAC/TGAAAA 2 -- ds50010--------
    rs1135048381,2
    C,F--34905253(+) CTCCTC/ACTGGG 2 -- ds50013Minor allele frequency- A:0.05CSA WA 122
    rs412681831,2
    C--34905362(-) AAATCG/AGAGTG 2 -- ds50015Minor allele frequency- A:0.01NS NA 154
    rs1444346481,2
    --34905363(+) ACTCCC/GATTTC 2 -- ds50010--------
    rs3424711,2
    C,F,H--34905412(+) GACAAG/TCAATG 2 -- ut31 nc-transcript-variant12Minor allele frequency- T:0.01EA NA MN NS WA 1150
    rs1480186921,2
    --34905503(+) CTTTTA/GGCAAT 2 -- ut31 nc-transcript-variant0--------
    rs1416836041,2
    --34905582(+) TGTTAC/GATGCC 2 -- ut31 nc-transcript-variant0--------
    rs412681811,2
    C,F--34905651(-) CCACCG/TAGAAT 2 -- ut31 nc-transcript-variant4Minor allele frequency- T:0.00NS 160

    HapMap Linkage Disequilibrium report for RAD1 (34905365 - 34919094 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RAD1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAD1
    DNA2.0 Custom Variant and Variant Library Synthesis for RAD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603153    OMIM disorders: --


    Find genes that share disorders with RAD1           About GenesLikeMe

    Genetic Association Database (GAD): RAD1
    Human Genome Epidemiology (HuGE) Navigator: RAD1 (82 documents)

    Export disorders for RAD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAD1 gene, integrated from 10 sources (see all 74):
    (articles sorted by number of sources associating them with RAD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human and mouse homolog of the Schizosaccharomyces pombe rad1+ cell cycle checkpoint control gene. (PubMed id 9828137)1, 2, 3, 9 Bluyssen H.A.R.... de Klein A. (Genomics 1998)
    2. Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis. (PubMed id 9716408)1, 2, 3, 9 Freire R....Jackson S.P. (Genes Dev. 1998)
    3. The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9. (PubMed id 10884395)1, 2, 9 Rauen M.... Karnitz L.M. (J. Biol. Chem. 2000)
    4. cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster. (PubMed id 9878245)1, 2, 9 Dean F.B.... O'Donnell M. (Genomics 1998)
    5. The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1. (PubMed id 10359610)1, 2, 9 St Onge R.P.... Davey S. (Mol. Biol. Cell 1999)
    6. The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9. (PubMed id 11573955)1, 2, 9 Xiang S.L....Yamamoto K.C. (Biochem. Biophys. Res. Commun. 2001)
    7. RAD1, a human structural homolog of the Schizosaccharomyces pombe RAD1 cell cycle checkpoint gene. (PubMed id 9828139)1, 2, 9 Marathi U.K.... Legerski R.J. (Genomics 1998)
    8. A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonuclease. (PubMed id 9660799)1, 2, 9 Parker A.E.... Luyten W.H.M.L. (J. Biol. Chem. 1998)
    9. Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells. (PubMed id 15897895)1, 2, 9 Wu X.... Zou Y. (Oncogene 2005)
    10. The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair. (PubMed id 15314187)1, 2, 9 Toueille M....Huebscher U. (Nucleic Acids Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5810 HGNC: 9806 AceView: RAD1 Ensembl:ENSG00000113456 euGenes: HUgn5810
    ECgene: RAD1 H-InvDB: RAD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RAD1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAD1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rad1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAD1 gene:
    Search GeneIP for patents involving RAD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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