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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAD1 Gene

protein-coding   GIFtS: 60
GCID: GC05M034905

RAD1 homolog (S. pombe)

(Previous name: RAD1 (S. pombe) homolog )
 Explore 8 diseases affiliated with
RAD1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RAD1    

Aliases
for RAD1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
RAD1 Homolog (S. Pombe)1 2     Cell Cycle Checkpoint Protein RAD12
REC11 2 3     Checkpoint Control Protein HRAD12
HRAD11 2     DNA Repair Exonuclease REC12
Rad1-Like DNA Damage Checkpoint Protein2 3     Exonuclease Homolog RAD12
DNA Repair Exonuclease Rad1 Homolog2 3     EC 3.1.11.23
RAD1 (S. Pombe) Homolog1     HRAD11 2
Cell Cycle Checkpoint Protein Hrad12     

External Ids:    HGNC: 98061   Entrez Gene: 58102   Ensembl: ENSG000001134567   OMIM: 6031535   UniProtKB: O606713   
ORGUL members:         
NONCODE:n407172    

Export aliases for RAD1 gene to outside databases

Previous GC identifers: GC05M034941 GC05M035934 GC05M034953 GC05M034944 GC05M034854


Summaries
for RAD1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RAD1:
This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is
activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is
recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors.
Alternatively spliced transcript variants of this gene have been described. (provided by RefSeq, Jan 2009)

UniProtKB/Swiss-Prot: RAD1_HUMAN, O60671
Function: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The
9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex.
Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair
(LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH
end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage
activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on
long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of
double-stranded breaks (DSB) occurring during the S phase. Isoform 1 possesses 3'->5' double stranded DNA exonuclease
activity

Gene Wiki entry for RAD1 (RAD1 homolog)


Genomic Views
for RAD1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAD1 gene promoter:
         GR   GR-alpha   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RAD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RAD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.2   Ensembl cytogenetic band:  5p13.2   HGNC cytogenetic band: 5p13

RAD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAD1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M034905:  view genomic region     (about GC identifiers)

Start:
 34,905,365 bp from pter      End:
 34,919,094 bp from pter
Size:
 13,730 bases      Orientation:
 minus strand

Proteins
for RAD1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RAD1_HUMAN, O60671 (See protein sequence)
Recommended Name: Cell cycle checkpoint protein RAD1  
Size: 282 amino acids; 31827 Da
Subunit: Component of the toroidal 9-1-1 (RAD9-RAD1-HUS1) complex, composed of RAD9A, RAD1 and HUS1. The 9-1-1 complex
associates with LIG1, POLB, FEN1, RAD17, HDAC1, RPA1 and RPA2. The 9-1-1 complex associates with the RAD17-RFC
complex. RAD1 interacts with POLB, FEN1, HUS1, HUS1B, RAD9A and RAD9B. Interacts with DNAJC7
Subcellular location: Nucleus
Sequence caution: Sequence=AAC35550.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAC35550.1; Type=Frameshift; Positions=103; Sequence=CAA06249.1; Type=Erroneous initiation; Note=Translation
N-terminally extended; Sequence=CAA06249.1; Type=Frameshift; Positions=103;
3 PDB 3D structures from and Proteopedia for RAD1:
3A1J (3D)        3G65 (3D)        3GGR (3D)    
Secondary accessions: O75572 O95304 Q1W161 Q5KSM0 Q5KSM1 Q9UEP1
Alternative splicing: 3 isoforms:  O60671-1   O60671-2   O60671-3   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for RAD1: NX_O60671

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60671

    • RAD1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002844.1  
    ENSEMBL proteins: 
     ENSP00000371469   ENSP00000340879   ENSP00000313467   ENSP00000421007   ENSP00000423253  
    Reactome Protein details: O60671
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Enzo Life Sciences proteins for RAD1
    OriGene Purified Protein: RAD1
    OriGene Protein Over-expression Lysate (see all 2): RAD1
    OriGene Custom Protein Services for RAD1 
    GenScript Custom Purified and Recombinant Proteins Services for RAD1
    Novus Biologicals RAD1 Proteins
    Novus Biologicals RAD1 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for RAD1
    Uscn Proteins for RAD1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--


    RAD1 for ontologies           About GeneDecksing



    RAD1 Antibody Products: 
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    Search for Antibodies for RAD1 at Abcam  
    Uscn Antibodies for RAD1
    ThermoFisher Antibodies for RAD1

    Assay Products for RAD1: 
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    Uscn ELISAs and CLIAs for RAD1

    Protein Domains /
    Families
    for RAD1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RAD1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR003011 Cell_cycle_checkpoint_Rad1
     IPR003021 Rad1_Rec1_Rad17

    Graphical View of Domain Structure for InterPro Entry O60671

    ProtoNet protein and cluster: O60671

    2 Blocks protein families:
    IPB003011 Rad1 repair protein signature
    IPB003021 Repair protein Rad1/Rec1 family signature


    UniProtKB/Swiss-Prot: RAD1_HUMAN, O60671
    Similarity: Belongs to the rad1 family


    Function
    for RAD1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RAD1_HUMAN, O60671
    Function: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The
    9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex.
    Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair
    (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH
    end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage
    activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on
    long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of
    double-stranded breaks (DSB) occurring during the S phase. Isoform 1 possesses 3'->5' double stranded DNA exonuclease
    activity
    Catalytic activity: Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates

         Genatlas biochemistry entry for RAD1:
    cell cycle G2 checkpoint control gene,also involved in DNA repair,homologous to RAD17,S pombe Rad1,S.cerevisiae,with
    two alternatively spliced isoforms (large RAD1-b and short RAD1-c),ubiquitously expressed,may be involved in lung
    carcinoma

    Enzyme Number (IUBMB): EC 3.1.11.21

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAD1
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate RAD1 (see all 14):
    hsa-miR-577 hsa-miR-582-3p hsa-miR-576-5p hsa-miR-376b hsa-miR-944 hsa-miR-551b* hsa-miR-4260 hsa-miR-376a
    SwitchGear 3'UTR luciferase reporter plasmid: RAD1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAD1 (see all 7)
    OriGene shRNA RFP: RAD1
    OriGene siRNA: RAD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAD1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RAD1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAD1 (see all 4)
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    GenScript: all cDNA clones in your preferred vector: RAD1 (NM_002853)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD1 

    Cell Line
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    Search LifeMap BioReagents cell lines for RAD1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003684damaged DNA binding NAS9660799
    GO:0005515protein binding IPI19464297
    GO:00084083'-5' exonuclease activity IDA9660799
    GO:0008853exodeoxyribonuclease III activity IEA--


    RAD1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for RAD1:
     Upregulation of Wnt/beta-caten 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Rad1):
     immune system 

    RAD1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RAD1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of ATR in response to replication stress
    		Activation of ATR in response to replication stress1.00
    		G2/M Checkpoints0.86
    2Chks in Checkpoint Regulation
    		Chks in Checkpoint Regulation1.00
    		DNA Repair Mechanisms0.32
    3Cell Cycle
    		Cell Cycle1.00
    4Regulation of Telomerase
    		Regulation of Telomerase1.00
    5DNA Damage Induced 14-3-3Sigma Signaling
    		DNA Damage Induced 14-3-3Sigma Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RAD1
        DNA Repair Mechanisms
    Chks in Checkpoint Regulation
    DNA Damage Induced 14-3-3Sigma Signaling

    2 BioSystems Pathways for RAD1 
        DNA damage response
    Regulation of Telomerase

    4        Reactome Pathways for RAD1
        Activation of ATR in response to replication stress
    Cell Cycle
    G2/M Checkpoints
    Cell Cycle Checkpoints



    RAD1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/58 Interacting proteins for RAD1 (O606711, 2, 3 ENSP000003408794) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HUS1O609211, 3, ENSP000002587744EBI-721835,EBI-1056174 I2D: score=3 STRING: ENSP00000258774
    RAD9AQ996381, 3, ENSP000003113604EBI-721835,EBI-2606224 I2D: score=2 STRING: ENSP00000311360
    MAP1LC3BQ9GZQ82, 3MINT-65697 I2D: score=3 
    FEN1P397483, ENSP000003054804I2D: score=2 STRING: ENSP00000305480
    CALRP277973, ENSP000003208664I2D: score=1 STRING: ENSP00000320866
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS--
    GO:0000077DNA damage checkpoint IMP--
    GO:0006260DNA replication TAS--
    GO:0006281DNA repair IEA--
    GO:0006974response to DNA damage stimulus TAS9872989


    RAD1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RAD1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAD1
    Search CenterWatch for drugs/clinical trials and news about RAD1 

    Transcripts
    for RAD1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RAD1 gene (4 alternative transcripts): 
    NM_002853.3  NM_001033673.1  NM_133282.1  NM_133377.2  

    Unigene Cluster for RAD1:

    RAD1 homolog (S. pombe)
    Hs.38114  [show with all ESTs]
    Unigene Representative Sequence: NM_002853
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382038(uc003jiw.3 uc003jix.3 uc003jiy.3) ENST00000341754
    ENST00000325577 ENST00000513914 ENST00000511456 ENST00000512192 ENST00000506311


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAD1
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate RAD1 (see all 14):
    hsa-miR-577 hsa-miR-582-3p hsa-miR-576-5p hsa-miR-376b hsa-miR-944 hsa-miR-551b* hsa-miR-4260 hsa-miR-376a
    SwitchGear 3'UTR luciferase reporter plasmid: RAD1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAD1 (see all 7)
    OriGene shRNA RFP: RAD1
    OriGene siRNA: RAD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAD1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAD1 (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RAD1 (NM_002853)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD1 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAD1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAD1

    Additional cDNA sequence: 

    AF011905.1 AF030933.1 AF058392.1 AF058393.1 AF073524.1 AF074717.1 AF076841.1 AF084512.1 
    AF084513.1 AF090170.1 AJ004974.1 AJ004975.1 AK002112.1 AK096960.1 AK125316.1 BC006837.1 
    BC009804.1 BC035771.1 BC037857.1 BT006908.1 NR_026591.1 

    17 DOTS entries:

    DT.444475  DT.100024236  DT.309747  DT.97841332  DT.99972608  DT.100798519  DT.100798520  DT.120802598 
    DT.75103106  DT.100033743  DT.75114249  DT.92435047  DT.97764608  DT.100728535  DT.425390  DT.92044223 
    DT.92430524 

    24/213 AceView cDNA sequences (see all 213):

    CA432131 BM802547 CR610090 AI245063 AA525955 N70774 BI715203 BQ027826 
    CD365064 BM453151 AU142492 AJ004974 BM469142 CN482823 CB116210 CF527867 
    AF090170 AA516368 AA029300 BU192569 AW779759 BU740949 AI798551 BQ771583 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RAD1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
    SP1:                    -     -                                             
    SP2:                                                                        
    SP3:              -     -     -     -     -                                 
    SP4:                    -     -     -                                       
    SP5:                                                                        


    ECgene alternative splicing isoforms for RAD1

    Expression
    for RAD1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAATAAATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See RAD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAD1

    SOURCE GeneReport for Unigene cluster: Hs.38114

    UniProtKB/Swiss-Prot: RAD1_HUMAN, O60671
    Tissue specificity: Expressed in testis, uterus, bladder, spleen, ovaries, lung, brain and muscle (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Arrays including RAD1: 
              Cell Cycle in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAD1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD1

    Orthologs
    for RAD1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAD1 gene from 9/30 species (see all 30)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rad11 , 5 RAD1 homolog (S. pombe)1, 5 87.26(n)1
    90.71(a)1    		   15 (5.35 cM)5
    193551  NM_011232.21  NP_035362.21 
     104860185 
    chicken
    (Gallus gallus)    		 Aves RAD11 RAD1 homolog (S. pombe) 75.24(n)
    83.21(a)    		   427432  XM_425004.3  XP_425004.2 
    lizard
    (Anolis carolinensis)    		 Reptilia RAD16
    		 --
    		 88(a)
    		 1 ↔ 1
    		 GL343241.1(2045607-2049289)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Rad12 checkpoint protein 77.12(n)    AY253233.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc777792 hypothetical protein MGC77779 76.09(n)   393872  BC049464.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG343141 CG34314 44.4(n)
    31.6(a)    		   5740299  NM_058092.3  NP_477440.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea mrt-21 Protein MRT-2 45.43(n)
    29.84(a)    		   176608  NM_067120.3  NP_499521.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G177606
    		 cell cycle checkpoint protein
    		 24(a)
    		 1 ↔ 1
    		 4(9871789-9873398)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 rad1, putative, expressed
    		 23(a)
    		 1 ↔ 1
    		 6(1753352-1759885)


    ENSEMBL Gene Tree for RAD1 (if available)
    TreeFam Gene Tree for RAD1 (if available) 

    Paralogs
    for RAD1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAD1 gene

    RAD1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RAD1
    PGOHUM00000238938 PGOHUM00000244302


    Genomic Variants
    for RAD1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/228 NCBI SNPs in RAD1 are shown (see all 228)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1449015061,2
    		--34904945(+) AGGGTC/TTACTA 2 -- ds50010--------
    rs1387440651,2
    		--34904967(+) CCTTTC/TTACTT 2 -- ds50010--------
    rs350697391,2
    		--34905158(+) AGATAC/TGAAAA 2 -- ds50010--------
    rs1135048381,2
    		F,--34905253(+) CTCCTC/ACTGGG 2 -- ds50013Minor allele frequency- A:0.05CSA WA 122
    rs412681831,2
    		C,--34905362(-) AAATCG/AGAGTG 2 -- ds50015Minor allele frequency- A:0.01NS NA 154
    rs1444346481,2
    		--34905363(+) ACTCCC/GATTTC 2 -- ds50010--------
    rs3424711,2
    		C,F,H,--34905412(+) GACAAG/TCAATG 2 -- nc-transcript-variantut3112Minor allele frequency- T:0.01EA NA MN NS WA 1150
    rs1480186921,2
    		--34905503(+) CTTTTA/GGCAAT 2 -- nc-transcript-variantut310--------
    rs1416836041,2
    		--34905582(+) TGTTAC/GATGCC 2 -- ut31 nc-transcript-variant0--------
    rs412681811,2
    		C,--34905651(-) CCACCG/TAGAAT 2 -- nc-transcript-variantut314Minor allele frequency- T:0.00NS 160

    HapMap Linkage Disequilibrium report for RAD1 (34905365 - 34919094 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RAD1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAD1
    DNA2.0 Custom Variant and Variant Library Synthesis for RAD1

    Disorders / Diseases
    for RAD1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RAD1 for disorders           About GeneDecksing

    OMIM gene information: 603153    OMIM disorders: --

    8 diseases for RAD1:    About MalaCards
    xeroderma pigmentosum    sporadic breast cancer    chronic lymphocytic leukemia    lymphocytic leukemia
    breast cancer    lung carcinoma    leukemia    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: RAD1 (82 documents)

    Export disorders for RAD1 gene to outside databases

    Publications
    for RAD1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAD1 gene, integrated from 9 sources (see all 71):
    (articles sorted by number of sources associating them with RAD1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A human and mouse homolog of the Schizosaccharomyces pombe rad1+ cell cycle checkpoint control gene. (PubMed id 9828137)1, 2, 3, 9 Bluyssen H.A....de Klein A. (1998)
    2. Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis. (PubMed id 9716408)1, 2, 3, 9 Freire R....Jackson S.P. (1998)
    3. The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9. (PubMed id 10884395)1, 2, 9 Rauen M.... Karnitz L.M. (2000)
    4. cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster. (PubMed id 9878245)1, 2, 9 Dean F.B.... O'Donnell M. (1998)
    5. The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1. (PubMed id 10359610)1, 2, 9 St Onge R.P.... Davey S. (1999)
    6. The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9. (PubMed id 11573955)1, 2, 9 Xiang S.L....Yamamoto K.C. (2001)
    7. RAD1, a human structural homolog of the Schizosaccharomyces pombe RAD1 cell cycle checkpoint gene. (PubMed id 9828139)1, 2, 9 Marathi U.K.... Legerski R.J. (1998)
    8. A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonuclease. (PubMed id 9660799)1, 2, 9 Parker A.E.... Luyten W.H.M.L. (1998)
    9. Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells. (PubMed id 15897895)1, 2, 9 Wu X.... Zou Y. (2005)
    10. The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair. (PubMed id 15314187)1, 2, 9 Toueille M....Huebscher U. (2004)

    External Searches for RAD1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RAD1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5810 HGNC: 9806 AceView: RAD1 Ensembl:ENSG00000113456 euGenes: HUgn5810
    ECgene: RAD1 H-InvDB: RAD1

    Other Databases showing RAD1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RAD1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAD1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAD1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rad1/

    Intellectual Property
    for RAD1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RAD1 gene:
    Search GeneIP for patents involving RAD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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