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Aliases for RACK1 Gene

Aliases for RACK1 Gene

  • Receptor For Activated C Kinase 1 2 3 5
  • Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 2-Like 1 2 3
  • Guanine Nucleotide-Binding Protein Subunit Beta-Like Protein 12.3 3 4
  • Guanine Nucleotide-Binding Protein Subunit Beta-2-Like 1 3 4
  • Cell Proliferation-Inducing Gene 21 Protein 3 4
  • Human Lung Cancer Oncogene 7 Protein 3 4
  • GNB2L1 3 4
  • HLC-7 3 4
  • Protein Homologous To Chicken B Complex Protein, Guanine Nucleotide Binding 3
  • Guanine Nucleotide Binding Protein Beta Polypeptide 2-Like 1 3
  • Receptor Of Activated Protein C Kinase 1 3
  • Receptor Of Activated Protein Kinase C 1 3
  • Receptor For Activated C Kinase 4
  • Proliferation-Inducing Gene 21 3
  • Lung Cancer Oncogene 7 3
  • Gnb2-Rs1 3
  • H12.3 3
  • PIG21 3

External Ids for RACK1 Gene

Previous HGNC Symbols for RACK1 Gene

  • GNB2L1

Summaries for RACK1 Gene

GeneCards Summary for RACK1 Gene

RACK1 (Receptor For Activated C Kinase 1) is a Protein Coding gene. Diseases associated with RACK1 include Hay-Wells Syndrome and Hiv-1. Among its related pathways are CREB Pathway and Regulation of CFTR activity (norm and CF). An important paralog of this gene is WDR31.

UniProtKB/Swiss-Prot for RACK1 Gene

  • Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (PubMed:19674157). Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells. Enhances phosphorylation of HIV-1 Nef by PKCs. Promotes migration of breast carcinoma cells by binding to and activating RHOA.

Gene Wiki entry for RACK1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RACK1 Gene

Genomics for RACK1 Gene

Regulatory Elements for RACK1 Gene

Enhancers for RACK1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RACK1 on UCSC Golden Path with GeneCards custom track

Promoters for RACK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RACK1 Gene

Chromosome:
5
Start:
181,236,909 bp from pter
End:
181,248,096 bp from pter
Size:
11,188 bases
Orientation:
Minus strand

Genomic View for RACK1 Gene

Genes around RACK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RACK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RACK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RACK1 Gene

Proteins for RACK1 Gene

  • Protein details for RACK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63244-RACK1_HUMAN
    Recommended name:
    Receptor of activated protein C kinase 1
    Protein Accession:
    P63244
    Secondary Accessions:
    • B3KTJ0
    • D3DWS0
    • P25388
    • P99049
    • Q53HU2
    • Q5J8M6
    • Q5VLR4
    • Q6FH47

    Protein attributes for RACK1 Gene

    Size:
    317 amino acids
    Molecular mass:
    35077 Da
    Quaternary structure:
    • Interacts with CPNE3 (PubMed:20010870). May interact with ABCB4 (PubMed:19674157). Component of the small (40S) ribosomal subunit (By similarity). Interacts with the 80S ribosome. Exists as a monomer and also forms oligomers. Binds SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4, KRT1 and OTUB1. Interacts with SRC (via SH2 domain); the interaction is enhanced by tyrosine phosphorylation of RACK1. Recruited in a circadian manner into a nuclear complex which also includes BMAL1 and PRKCA. Interacts with AR. Interacts with IGF1R but not with INSR. Interacts with ADAM12. Interacts with CLEC1B (via N-terminal region) and with HIF1A; the interaction promotes their degradation. Interacts with RHOA; this enhances RHOA activation and promotes cell migration. Interacts with CHRM2; the interaction regulates CHRM2 internalization. Interacts with TRPM6 (via kinase domain). Interacts with PTK2/FAK1; required for PTK2/FAK1 phosphorylation and dephosphorylation. Interacts with FLT1. Interacts with TBXA2R isoform 2. Interacts with HRAS. Interacts with LARP4B. Interacts with PKD2L1. Interacts with Y.pseudotuberculosis yopK. Interacts with a number of viral proteins including Epstein-Barr virus BZLF1 and HIV-1 Nef; interaction with Nef increases Nef phosphorylation by PKC.
    SequenceCaution:
    • Sequence=AAO21313.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAR24619.1; Type=Frameshift; Positions=94; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RACK1 Gene

neXtProt entry for RACK1 Gene

Post-translational modifications for RACK1 Gene

  • Phosphorylated on Tyr-228 and/or Tyr-246 by SRC. This is required for binding to SRC.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RACK1 Gene

Domains & Families for RACK1 Gene

Gene Families for RACK1 Gene

Suggested Antigen Peptide Sequences for RACK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P63244

UniProtKB/Swiss-Prot:

RACK1_HUMAN :
  • Belongs to the WD repeat G protein beta family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat G protein beta family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with RACK1: view

Function for RACK1 Gene

Molecular function for RACK1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (PubMed:19674157). Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells. Enhances phosphorylation of HIV-1 Nef by PKCs. Promotes migration of breast carcinoma cells by binding to and activating RHOA.

Gene Ontology (GO) - Molecular Function for RACK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005080 protein kinase C binding IDA 11279199
GO:0005102 receptor binding NAS 12809483
GO:0005515 protein binding IEA,IPI 10849009
GO:0008200 ion channel inhibitor activity IEA,ISS --
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process IMP 19767770
genes like me logo Genes that share ontologies with RACK1: view
genes like me logo Genes that share phenotypes with RACK1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RACK1 Gene

Localization for RACK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RACK1 Gene

Cell membrane; Peripheral membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Perikaryon. Cell projection, dendrite. Cell projection, phagocytic cup. Note=Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1 (PubMed:17956333). Also associated with the membrane in oncogene-transformed cells (PubMed:11884618). PKC activation induces translocation from the perinuclear region to the cell periphery (PubMed:11279199). In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei (By similarity). Localized to phagocytic cups following infection by Y.pestis (PubMed:21347310). {ECO:0000250 UniProtKB:P68040, ECO:0000269 PubMed:11279199, ECO:0000269 PubMed:11884618, ECO:0000269 PubMed:17956333, ECO:0000269 PubMed:21347310}.

Gene Ontology (GO) - Cellular Components for RACK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001891 phagocytic cup IDA 21347310
GO:0005634 nucleus IDA 10849009
GO:0005737 cytoplasm IEA,IDA 10849009
GO:0005739 mitochondrion IMP 19767770
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RACK1: view

No data available for Subcellular locations from COMPARTMENTS for RACK1 Gene

Pathways & Interactions for RACK1 Gene

genes like me logo Genes that share pathways with RACK1: view

SIGNOR curated interactions for RACK1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for RACK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IEA --
GO:0001934 positive regulation of protein phosphorylation IDA 11312657
GO:0006915 apoptotic process IEA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IMP 19767770
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with RACK1: view

Drugs & Compounds for RACK1 Gene

(9) Drugs for RACK1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(9) Additional Compounds for RACK1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RACK1: view

Transcripts for RACK1 Gene

Unigene Clusters for RACK1 Gene

Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RACK1 Gene

No ASD Table

Relevant External Links for RACK1 Gene

GeneLoc Exon Structure for
RACK1
ECgene alternative splicing isoforms for
RACK1

Expression for RACK1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RACK1 Gene:

RACK1

SOURCE GeneReport for Unigene cluster for RACK1 Gene:

Hs.5662

mRNA Expression by UniProt/SwissProt for RACK1 Gene:

P63244-RACK1_HUMAN
Tissue specificity: In the liver, expressed at higher levels in activated hepatic stellate cells than in hepatocytes or Kupffer cells. Up-regulated in hepatocellular carcinomas and in the adjacent non-tumor liver tissue.

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for RACK1 Gene

Orthologs for RACK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RACK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GNB2L1 34
  • 92.22 (n)
  • 100 (a)
GNB2L1 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNB2L1 34
  • 90.12 (n)
  • 100 (a)
GNB2L1 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gnb2l1 34
  • 90.85 (n)
  • 100 (a)
Rack1 16
Gnb2l1 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GNB2L1 34
  • 99.47 (n)
  • 100 (a)
GNB2L1 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gnb2l1 34
  • 90.96 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia GNB2L1 35
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNB2L1 35
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves GNB2L1 34
  • 85.38 (n)
  • 100 (a)
GNB2L1 35
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GNB2L1 35
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gnb2l1 34
  • 80.97 (n)
  • 96.21 (a)
Str.6701 34
African clawed frog
(Xenopus laevis)
Amphibia gnb2l1-prov 34
zebrafish
(Danio rerio)
Actinopterygii gnb2l1 34
  • 83.81 (n)
  • 95.58 (a)
gnb2l1 35
  • 96 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1296 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010173 34
  • 70.09 (n)
  • 74.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rack1 34
  • 72.51 (n)
  • 77.39 (a)
Rack1 35
  • 76 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rack-1 34
  • 68.05 (n)
  • 73.57 (a)
rack-1 35
  • 68 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR199C 34
  • 59.07 (n)
  • 57.33 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E12277g 34
  • 55.74 (n)
  • 53.44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ASC1 34
  • 54.83 (n)
  • 55.05 (a)
ASC1 35
  • 51 (a)
OneToMany
ASC1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons RACK1C_AT 34
  • 61.97 (n)
  • 68.59 (a)
rice
(Oryza sativa)
Liliopsida Os05g0552300 34
  • 64.83 (n)
  • 67.31 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05810 34
  • 68.7 (n)
  • 71.47 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cpc2 34
  • 63.47 (n)
  • 64.22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4423 35
  • 73 (a)
OneToOne
Species where no ortholog for RACK1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RACK1 Gene

ENSEMBL:
Gene Tree for RACK1 (if available)
TreeFam:
Gene Tree for RACK1 (if available)

Paralogs for RACK1 Gene

Paralogs for RACK1 Gene

Pseudogenes.org Pseudogenes for RACK1 Gene

genes like me logo Genes that share paralogs with RACK1: view

Variants for RACK1 Gene

Sequence variations from dbSNP and Humsavar for RACK1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs254445 -- 181,239,706(+) AAACC(G/T)TTAAG intron-variant
rs6888852 -- 181,238,816(+) aaaaa(A/C)aaaca intron-variant
rs2287716 -- 181,239,276(-) AGAAA(C/T)GGCTA intron-variant
rs4976815 -- 181,240,697(-) ATTTA(A/T)TTTTT intron-variant
rs57708958 -- 181,240,525(+) GCATG(-/ATG)GCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RACK1 Gene

Variant ID Type Subtype PubMed ID
dgv1155e214 CNV gain 21293372
dgv1156e214 CNV loss 21293372
nsv1028730 CNV gain 25217958
nsv428133 CNV gain 18775914
nsv462591 CNV loss 19166990
nsv517697 CNV loss 19592680
nsv600731 CNV loss 21841781
nsv830567 CNV loss 17160897

Variation tolerance for RACK1 Gene

Residual Variation Intolerance Score: 28.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RACK1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RACK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RACK1 Gene

Disorders for RACK1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RACK1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hay-wells syndrome
  • ankyloblepharon ectodermal defects cleft lip/palate
hiv-1
  • aids, slow progression to
wells syndrome
  • eosinophilic cellulitis
- elite association - COSMIC cancer census association via MalaCards
Search RACK1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RACK1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RACK1
genes like me logo Genes that share disorders with RACK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RACK1 Gene

Publications for RACK1 Gene

  1. Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase. (PMID: 19423701) Kiely P.A. … O'Connor R. (J. Biol. Chem. 2009) 3 4 22 65
  2. Receptor for activated C-kinase 1 regulates the cellular localization and function of ABCB4. (PMID: 19674157) Ikebuchi Y. … Suzuki H. (Hepatol. Res. 2009) 3 4 22 65
  3. RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis. (PMID: 18621736) Bourd-Boittin K. … Theret N. (J. Biol. Chem. 2008) 3 4 22 65
  4. RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF- 1alpha. (PMID: 17244529) Liu Y.V. … Semenza G.L. (Mol. Cell 2007) 3 4 22 65
  5. Receptor for activated C kinase 1 (RACK1) and Src regulate the tyrosine phosphorylation and function of the androgen receptor. (PMID: 17108144) Kraus S. … Weber M.J. (Cancer Res. 2006) 3 4 22 65

Products for RACK1 Gene

Sources for RACK1 Gene

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