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RACGAP1 Gene

protein-coding   GIFtS: 65
GCID: GC12M050370

Rac GTPase Activating Protein 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rac GTPase Activating Protein 11 2     ID-GAP2
CYK42 3 5     GTPase Activating Protein2
Male Germ Cell RacGap2 3     Protein CYK4 Homolg2
Protein CYK4 Homolog2 3     Rac GTPase-Activating Protein 12
HsCYK-42 3     KIAA14783
MgcRacGAP2 3     RCGAP15
MGCRACGAP3 5     

External Ids:    HGNC: 98041   Entrez Gene: 291272   Ensembl: ENSG000001618007   OMIM: 6049805   UniProtKB: Q9H0H53   

Export aliases for RACGAP1 gene to outside databases

Previous GC identifers: GC12M050677 GC12M050438 GC12M050099 GC12M048669


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RACGAP1 Gene:
The protein encoded by this gene belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms
of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate
Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth
and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation.
Alternatively spliced transcript variants have been found for this gene. (provided by RefSeq, Sep 2011)

GeneCards Summary for RACGAP1 Gene:
RACGAP1 (Rac GTPase activating protein 1) is a protein-coding gene. GO annotations related to this gene include protein kinase binding and GTPase activator activity. An important paralog of this gene is SYDE2.

UniProtKB/Swiss-Prot: RGAP1_HUMAN, Q9H0H5
Function: Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated
signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for
proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell
growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity.
Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in
regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase
activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of
embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate
in the regulation of sulfate transport in male germ cells

Gene Wiki entry for RACGAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RACGAP1 gene promoter:
         TBP   SRY   FOXO4   FOXD3   FOXO1a   STAT3   AP-4   GATA-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRACGAP1 promoter sequence
   Search Chromatin IP Primers for RACGAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RACGAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.12   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13

RACGAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RACGAP1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M050370:  view genomic region     (about GC identifiers)

Start:
50,370,706 bp from pter      End:
50,426,919 bp from pter
Size:
56,214 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RGAP1_HUMAN, Q9H0H5 (See protein sequence)
Recommended Name: Rac GTPase-activating protein 1  
Size: 632 amino acids; 71027 Da
Subunit: Heterotetramer of two molecules each of RACGAP1 and KIF23. Found in the centralspindlin complex composed
of RACGAP1 and KIF23. Associates with alpha-, beta- and gamma-tubulin and microtubules. Interacts via its Rho-GAP
domain with RND2. Associates with AURKB during M phase. Interacts via its Rho-GAP domain and basic region with
PRC1. The interaction with PRC1 inhibits its GAP activity towards CDC42 in vitro, which may be required for
maintaining normal spindle morphology. Interacts with SLC26A8 via its N-terminus. Interacts with RAB11FIP3.
Interacts with ECT2; the interaction is direct, occurs at anaphase and during cytokinesis in a
microtubule-dependent manner and is enhanced by phosphorylation by PLK1. Interacts with KIF23; the interaction is
direct
Sequence caution: Sequence=AAH24144.1; Type=Frameshift; Positions=171, 205, 437;
2 PDB 3D structures from and Proteopedia for RACGAP1:
2OVJ (3D)        4B6D (3D)    
Secondary accessions: Q6PJ26 Q9NWN2 Q9P250 Q9P2W2

Explore the universe of human proteins at neXtProt for RACGAP1: NX_Q9H0H5

Explore proteomics data for RACGAP1 at MOPED

Post-translational modifications: 

  • Phosphorylated at multiple sites in the midbody during cytokinesis. Phosphorylation by AURKB on Ser-387 at the
    midbody is, at least in part, responsible for exerting its latent GAP activity towards RhoA. Phosphorylation on
    multiple serine residues by PLK1 enhances its association with ECT2 and is critical for cleavage furrow formation1
  • Ubiquitination2 at Lys173, Lys248, Lys292, Lys430, Lys490, Lys587
  • Modification sites at PhosphoSitePlus

  • See RACGAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001119575.1  NP_001119576.1  NP_037409.2  

    ENSEMBL proteins: 
     ENSP00000446889   ENSP00000404190   ENSP00000309871   ENSP00000404808   ENSP00000449374  
     ENSP00000449370   ENSP00000449565   ENSP00000448507   ENSP00000449574   ENSP00000448697  
     ENSP00000446642   ENSP00000447429   ENSP00000449963   ENSP00000450064   ENSP00000449170  
     ENSP00000448860   ENSP00000449620   ENSP00000449669   ENSP00000447393   ENSP00000448968  
     ENSP00000450074   ENSP00000447177   ENSP00000449186   ENSP00000448707   ENSP00000449959  
     ENSP00000448136   ENSP00000413241  
    Reactome Protein details: Q9H0H5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR008936 Rho_GTPase_activation_prot
     IPR002219 Prot_Kinase_C-like_PE/DAG-bd
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q9H0H5

    ProtoNet protein and cluster: Q9H0H5

    1 Blocks protein domain: IPB000198 RhoGAP domain

    UniProtKB/Swiss-Prot: RGAP1_HUMAN, Q9H0H5
    Domain: The coiled coil region is indispensible for localization to the midbody during cytokinesis
    Domain: The phorbol-ester/DAG-type zinc finger domain mediates interaction with membranes enriched in
    phosphatidylinositol 3,4,5-trisphosphate and is required during mitotic cytokinesis for normal attachment of the
    midbody to the cell membrane
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 Rho-GAP domain


    Find genes that share domains with RACGAP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGAP1_HUMAN, Q9H0H5
    Function: Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated
    signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for
    proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell
    growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity.
    Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in
    regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase
    activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of
    embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate
    in the regulation of sulfate transport in male germ cells
    Induction: Expression is down-regulated during macrophage differention of HL-60 cells

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IMP15642749
    GO:0005515protein binding IPI11278976
    GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding IDA--
    GO:0008017microtubule binding IDA11782313
    GO:0019901protein kinase binding IPI19468302
         
    Find genes that share ontologies with RACGAP1           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for RACGAP1:
     Cell division defect  Decreased cell number, increas  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 
     Decreased viability of wild-ty  Increased cell number in G2M,   Increased cilium length after  

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Racgap1):
     embryogenesis  hematopoietic system  immune system  mortality/aging 

    Find genes that share phenotypes with RACGAP1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RACGAP1

    miRNA
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    miRTarBase miRNAs that target RACGAP1:
    hsa-mir-26b-5p (MIRT029047), hsa-mir-193b-3p (MIRT016327), hsa-mir-215-5p (MIRT024375), hsa-mir-221-3p (MIRT046942), hsa-mir-16-5p (MIRT031559), hsa-let-7e-5p (MIRT051704), hsa-mir-192-5p (MIRT004859)

    Block miRNA regulation of human, mouse, rat RACGAP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RACGAP1 (see all 41):
    hsa-miR-576-3p hsa-miR-4254 hsa-miR-24-1* hsa-miR-106a hsa-miR-1224-3p hsa-miR-1260b hsa-miR-301a hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidRACGAP1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RGAP1_HUMAN, Q9H0H5: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasmic vesicle, secretory
    vesicle, acrosome. Cleavage furrow. Midbody. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
    Note=Colocalizes with RND2 in Golgi-derived proacrosomal vesicles and the acrosome (By similarity). During
    interphase, localized to the nucleus and cytoplasm along with microtubules, in anaphase, is redistributed to the
    central spindle and, in telophase and cytokinesis, to the midbody. Colocalizes with RHOA at the myosin
    contractile ring during cytokinesis. Colocalizes with ECT2 to the mitotic spindles during anaphase/metaphase, the
    cleavage furrow during telophase and at the midbody at the end of cytokinesis. Colocalizes with Cdc42 to spindle
    microtubules from prometaphase to telophase
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with RACGAP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RACGAP1 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Apoptotic Pathways in Synovial Fibroblasts
    Rac1 Pathway0.65
    3Signaling by GPCR
    Signal Transduction0.58
    4Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway and Pluripotency0.55
    5Hemostasis
    Hemostasis0.43


    Find genes that share SuperPaths with RACGAP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RACGAP1
        Rac1 Pathway

    2 GeneGo (Thomson Reuters) Pathways for RACGAP1
        G-protein signaling Regulation of RAC1 activity
    G-protein signaling Rac2 regulation pathway

    Selected BioSystems Pathways for RACGAP1 (see all 6)
        Signal Transduction of S1P Receptor
    Wnt Signaling Pathway and Pluripotency
    Regulation of CDC42 activity
    Aurora B signaling
    Regulation of RAC1 activity

    3 Reactome Pathways for RACGAP1
        Rho GTPase cycle
    MHC class II antigen presentation
    Kinesins


        Pathway & Disease-focused RT2 Profiler PCR Array including RACGAP1: 
              Cytoskeleton Regulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RACGAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RACGAP1 (Q9H0H51, 2, 3 ENSP000003098714) via UniProtKB, MINT, STRING, and/or I2D (see all 868)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAB11FIP3O751541, 2, 3, ENSP000002623054EBI-717233,EBI-7942186 MINT-6799593 MINT-6799707 MINT-6799722 MINT-6799583 MINT-6799628 MINT-6799646 MINT-6799664 I2D: score=1 STRING: ENSP00000262305
    PPP2R5EQ165371, 2, 3, ENSP000003376414EBI-717233,EBI-968374 MINT-6166710 MINT-6166735 MINT-6166596 MINT-6166691 MINT-6166659 MINT-6166727 I2D: score=2 STRING: ENSP00000337641
    KIF23Q022411, 2, 3, ENSP000002603634EBI-717233,EBI-306852 MINT-6799707 MINT-8397862 MINT-8400617 MINT-6166596 MINT-8397624 MINT-8397899 I2D: score=1 STRING: ENSP00000260363
    PPP2CAP677752, 3, ENSP000004184474MINT-6166596 MINT-6166653 I2D: score=2 STRING: ENSP00000418447
    TUBA4AP683662, 3, ENSP000002484374MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000248437
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000281mitotic cytokinesis IMP16236794
    GO:0000915actomyosin contractile ring assembly IMP16129829
    GO:0007018microtubule-based movement TAS--
    GO:0007108cytokinesis, initiation of separation IMP16129829
    GO:0007165signal transduction ----

    Find genes that share ontologies with RACGAP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for RACGAP1 (RGAP1)

    Selected HMDB Compounds for RACGAP1 (see all 843)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----
    DG(14:0/18:3(6Z,9Z,12Z)/0:0)Diacylglycerol(14:0/18:3n6) (see all 16)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RACGAP1 gene (3 alternative transcripts): 
    NM_001126103.1  NM_001126104.1  NM_013277.3  

    Unigene Cluster for RACGAP1:

    Rac GTPase activating protein 1
    Hs.505469  [show with all ESTs]
    Unigene Representative Sequence: NM_001126103
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):
    ENST00000548961 ENST00000427314 ENST00000312377 ENST00000454520 ENST00000551016
    ENST00000547905 ENST00000549342 ENST00000547061 ENST00000548320 ENST00000548598
    ENST00000552310 ENST00000548158 ENST00000550149 ENST00000546786 ENST00000546595
    ENST00000551145 ENST00000548824 ENST00000551260
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    Additional mRNA sequence: 

    AB030251.1 AB040911.1 AK000733.1 AK022726.1 AK225901.1 AK315785.1 AL136794.1 BC024144.2 
    BC032754.1 CR533565.1 

    15 DOTS entries:

    DT.445826  DT.100797704  DT.100797709  DT.100797710  DT.95319330  DT.100797706  DT.102830933  DT.100036361 
    DT.100728933  DT.121129817  DT.121129861  DT.92060622  DT.99942987  DT.100036360  DT.91997253 

    Selected AceView cDNA sequences (see all 236):

    BM557222 BQ228488 BG289047 CB115198 BI093200 BX388364 CR615917 W72501 
    BU167875 AL713621 BP365058 BU154041 W61248 NM_013277 BX400548 CR603322 
    BM800554 BX367703 BQ217059 BQ923596 BU187575 AA865130 BG258163 BF082592 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RACGAP1 (see all 19)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
    SP1:                                            -     -     -     -     -                                                                                       
    SP2:                                                        -     -     -                                                                                       
    SP3:                                                  -     -     -     -                                                                                       
    SP4:                                            -     -     -     -                                                                                             
    SP5:                                            -     -     -     -     -                                                                                       

    ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for RACGAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    RACGAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAACATAGCC
    RACGAP1 Expression
    About this image


    RACGAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Bone marrow-derived hematopoietic stem cells (family)
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Neural Tube (Nervous System)
             Mesencephalic Ventricular Zone
     
     Brain (Nervous System)
             Choroid Plexus Progenitor Cells Choroid Plexus
    RACGAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RACGAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.505469

    UniProtKB/Swiss-Prot: RGAP1_HUMAN, Q9H0H5
    Tissue specificity: Highly expressed in testis, thymus and placenta. Expressed at lower levels in spleen and
    peripheral blood lymphocytes. In testis, expression is restricted to germ cells with the highest levels of
    expression found in spermatocytes. Expression is regulated in a cell cycle-dependent manner and peaks during G2/M
    phase

        Pathway & Disease-focused RT2 Profiler PCR Array including RACGAP1: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RACGAP1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Racgap11 , 5 Rac GTPase-activating protein 11, 5 84.26(n)1
    85.17(a)1
      15 (56.13 cM)5
    269341  NM_001253808.11  NP_001240737.11 
     996204965 
    chicken
    (Gallus gallus)
    Aves RACGAP11 Rac GTPase activating protein 1 74.87(n)
    78.73(a)
      426884  XM_004949732.1  XP_004949789.1 
    lizard
    (Anolis carolinensis)
    Reptilia RACGAP16
    Rac GTPase activating protein 1
    81(a)
    1 ↔ 1
    2(92175914-92205951)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC530482 similar to Rac GTPase activating protein 1 74.52(n)    BC046676.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb92c082 wufb92c08 74.28(n)   323197  BC063983.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RacGAP84C3
    tum1
    limb morphogenesis RAS GTPase activator3
    tumbleweed1
    41(a)
    (best of 2)3
    48.06(n)1
    39.33(a)1
      84D33
    365381  NM_137068.31  NP_610912.21 
    worm
    (Caenorhabditis elegans)
    Secernentea cyk-43 Phorbol esters/diacylglycerol binding
    domain (C1 more
    32(a)   III(13840084-13842506)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BEM26
    Rho GTPase activating protein (RhoGAP) involved in...
    5(a)
    1 → many
    V(476345-482848) YER155C


    ENSEMBL Gene Tree for RACGAP1 (if available)
    TreeFam Gene Tree for RACGAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RACGAP1 gene
    SYDE22  ABR2  SYDE12  BCR2  
    3 SIMAP similar genes for RACGAP1 using alignment to 22 protein entries:     RGAP1_HUMAN (see all proteins):
    FKSG42    ARHGAP12    ARHGAP9

    Find genes that share paralogs with RACGAP1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for RACGAP1
    PGOHUM00000239430 PGOHUM00000247791 PGOHUM00000246146


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for RACGAP1 (see all 804)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1505391671,2
    --50382515(+) ACTCCC/TGGTGG 3 -- ds50010--------
    rs1394983431,2
    C--50382594(+) GAAGTA/GATTTT 3 -- ds50010--------
    rs1431910751,2
    --50382753(+) ACCACA/GCCCAG 3 -- ds50010--------
    rs1140262501,2
    C,F--50383028(+) GTCAAA/CCATTC 3 -- ut311Minor allele frequency- C:0.03WA 118
    rs1461764931,2
    C--50383120(+) TTCCAC/TGGGAA 3 -- ut310--------
    rs89871,2
    C--50383150(+) GCAAAG/AAAAAA 3 -- ut311Minor allele frequency- A:0.00NA 2
    rs1903562251,2
    --50383175(+) TCTTAC/TCACAA 3 -- ut310--------
    rs1394469441,2
    C--50383286(+) TGGGGG/TTATGG 3 -- ut310--------
    rs1816791111,2
    --50383287(+) GGGGGA/TATGGG 3 -- ut310--------
    rs74859211,2
    C--50383327(+) AAAGAA/CAAACT 3 -- ut31 trp30--------

    HapMap Linkage Disequilibrium report for RACGAP1 (50370706 - 50426919 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RACGAP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1766563CNV Insertion17803354
    esv271791CNV Insertion20981092
    esv1010880CNV Insertion20482838
    nsv832407CNV Loss17160897
    nsv522972CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RACGAP1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604980    OMIM disorders: --


    Find genes that share disorders with RACGAP1           About GenesLikeMe

    Genetic Association Database (GAD): RACGAP1
    Human Genome Epidemiology (HuGE) Navigator: RACGAP1 (3 documents)

    Export disorders for RACGAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RACGAP1 gene, integrated from 10 sources (see all 93):
    (articles sorted by number of sources associating them with RACGAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cells. (PubMed id 9497316)1, 2, 3, 9 Toure A....Gacon G. (J. Biol. Chem. 1998)
    2. Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells. (PubMed id 12590651)1, 2, 9 Naud N.... Gacon G. (Biochem. J. 2003)
    3. MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis. (PubMed id 16129829)1, 2, 9 Zhao W.-M. and Fang G. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    4. Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. (PubMed id 19468302)1, 2, 9 Burkard M.E.... Jallepalli P.V. (PLoS Biol. 2009)
    5. Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase. (PubMed id 14744859)1, 2, 9 Ban R.... Tanaka H. (J. Biol. Chem. 2004)
    6. Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis. (PubMed id 23235882)1, 2 Lekomtsev S....Petronczki M. (Nature 2012)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis. (PubMed id 18511905)1, 2 Simon G.C.... Prekeris R. (EMBO J. 2008)
    9. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    10. Dissecting the role of Rho-mediated signaling in contractile ring formation. (PubMed id 16236794)1, 2 Kamijo K....Miki T. (Mol. Biol. Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29127 HGNC: 9804 AceView: RACGAP1 Ensembl:ENSG00000161800 euGenes: HUgn29127
    ECgene: RACGAP1 H-InvDB: RACGAP1

    (According to HUGE)
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    HUGE: KIAA1478

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RACGAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RACGAP1 gene:
    Search GeneIP for patents involving RACGAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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