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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RACGAP1 Gene

protein-coding   GIFtS: 65
GCID: GC12M050370

Rac GTPase Activating Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rac GTPase Activating Protein 11 2     ID-GAP2
Male Germ Cell RacGap2 3     GTPase Activating Protein2
Protein CYK4 Homolog2 3     Protein CYK4 Homolg2
CYK42 3     Rac GTPase-Activating Protein 12
HsCYK-42 3     KIAA14783
MgcRacGAP2 3     MGCRACGAP3

External Ids:    HGNC: 98041   Entrez Gene: 291272   Ensembl: ENSG000001618007   OMIM: 6049805   UniProtKB: Q9H0H53   

Export aliases for RACGAP1 gene to outside databases

Previous GC identifers: GC12M050677 GC12M050438 GC12M050099 GC12M048669


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RACGAP1 Gene:
The protein encoded by this gene belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms
of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate
Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth
and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation.
Alternatively spliced transcript variants have been found for this gene. (provided by RefSeq, Sep 2011)

GeneCards Summary for RACGAP1 Gene: 
RACGAP1 (Rac GTPase activating protein 1) is a protein-coding gene. Diseases associated with RACGAP1 include neuronitis, and endotheliitis, and among its related super-pathways are Immune System and Signaling by Rho GTPases. GO annotations related to this gene include microtubule binding and protein kinase binding. An important paralog of this gene is ARHGAP29.

UniProtKB/Swiss-Prot: RGAP1_HUMAN, Q9H0H5
Function: Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated
signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Plays key roles
in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating
Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May
be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP
(GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of
embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate
in the regulation of sulfate transport in male germ cells

Gene Wiki entry for RACGAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RACGAP1 gene promoter:
         TBP   SRY   FOXO4   FOXD3   FOXO1a   STAT3   AP-4   GATA-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRACGAP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RACGAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RACGAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.12   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13

RACGAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RACGAP1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M050370:  view genomic region     (about GC identifiers)

Start:
50,370,706 bp from pter      End:
50,426,919 bp from pter
Size:
56,214 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RGAP1_HUMAN, Q9H0H5 (See protein sequence)
Recommended Name: Rac GTPase-activating protein 1  
Size: 632 amino acids; 71027 Da
Subunit: Heterotetramer of two molecules each of RACGAP1 and KIF23. Found in the centralspindlin complex composed
of RACGAP1 and KIF23. Associates with alpha-, beta- and gamma-tubulin and microtubules. Interacts via its Rho-GAP
domain with RND2. Associates with AURKB during M phase. Interacts via its Rho-GAP domain and basic region with
PRC1. The interaction with PRC1 inhibits its GAP activity towards CDC42 in vitro, which may be required for
maintaining normal spindle morphology. Interacts with SLC26A8 via its N-terminus. Interacts with RAB11FIP3.
Interacts with ECT2; the interaction is direct, occurs at anaphase and during cytokinesis in a
microtubule-dependent manner and is enhanced by phosphorylation by PLK1. Interacts with KIF23; the interaction is
direct
Subcellular location: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasmic vesicle, secretory
vesicle, acrosome. Cleavage furrow. Midbody. Note=Colocalizes with RND2 in Golgi-derived proacrosomal vesicles
and the acrosome (By similarity). During interphase, localized to the nucleus and cytoplasm along with
microtubules, in anaphase, is redistributed to the central spindle and, in telophase and cytokinesis, to the
midbody. Colocalizes with RHOA at the myosin contractile ring during cytokinesis. Colocalizes with ECT2 to the
mitotic spindles during anaphase/metaphase, the cleavage furrow during telophase and at the midbody at the end of
cytokinesis. Colocalizes with Cdc42 to spindle microtubules from prometaphase to telophase
Sequence caution: Sequence=AAH24144.1; Type=Frameshift; Positions=171, 205, 437;
2 PDB 3D structures from and Proteopedia for RACGAP1:
2OVJ (3D)        4B6D (3D)    
Secondary accessions: Q6PJ26 Q9NWN2 Q9P250 Q9P2W2

Explore the universe of human proteins at neXtProt for RACGAP1: NX_Q9H0H5

Explore proteomics data for RACGAP1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated at multiple sites in the midbody during cytokinesis. Phosphorylation by AURKB on Ser-387 at the
    midbody is, at least in part, responsible for exerting its latent GAP activity towards RhoA. Phosphorylation on
    multiple serine residues by PLK1 enhances its association with ECT2 and is critical for cleavage furrow formation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H0H5

  • RACGAP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RACGAP1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001119575.1  NP_001119576.1  NP_037409.2  

    ENSEMBL proteins: 
     ENSP00000446889   ENSP00000404190   ENSP00000309871   ENSP00000404808   ENSP00000449374  
     ENSP00000449370   ENSP00000449565   ENSP00000448507   ENSP00000449574   ENSP00000448697  
     ENSP00000446642   ENSP00000447429   ENSP00000449963   ENSP00000450064   ENSP00000449170  
     ENSP00000448860   ENSP00000449620   ENSP00000449669   ENSP00000447393   ENSP00000448968  
     ENSP00000450074   ENSP00000447177   ENSP00000449186   ENSP00000448707   ENSP00000449959  
     ENSP00000448136   ENSP00000413241  
    Reactome Protein details: Q9H0H5
    Human Recombinant Protein Products for RACGAP1: 
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    Novus Biologicals RACGAP1 Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RACGAP1 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005829cytosol TAS--
    GO:0005874microtubule IEA--

    RACGAP1 for ontologies           About GeneDecksing



    RACGAP1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR008936 Rho_GTPase_activation_prot
     IPR002219 Prot_Kinase_C-like_PE/DAG-bd
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q9H0H5

    ProtoNet protein and cluster: Q9H0H5

    1 Blocks protein domain: IPB000198 RhoGAP domain

    UniProtKB/Swiss-Prot: RGAP1_HUMAN, Q9H0H5
    Domain: The coiled coil region is indispensible for localization to the midbody during cytokinesis
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 Rho-GAP domain


    RACGAP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGAP1_HUMAN, Q9H0H5
    Function: Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated
    signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Plays key roles
    in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating
    Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May
    be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP
    (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of
    embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate
    in the regulation of sulfate transport in male germ cells
    Induction: Expression is down-regulated during macrophage differention of HL-60 cells

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IMP15642749
    GO:0005515protein binding IPI11278976
    GO:0008017microtubule binding IDA11782313
    GO:0019901protein kinase binding IPI19468302
    GO:0043014alpha-tubulin binding IDA11085985
         
    RACGAP1 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for RACGAP1:
     Cell division defect  Decreased cell number, increas  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 
     Decreased viability of wild-ty  Increased cell number in G2M,   Increased cilium length after  

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Racgap1):
     cellular  embryogenesis  hematopoietic system  immune system  mortality/aging 

    RACGAP1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RACGAP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RACGAP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RACGAP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RACGAP1 

    miRNA
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    miRTarBase miRNAs that target RACGAP1:
    hsa-mir-192 (MIRT004859)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RACGAP1
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate RACGAP1 (see all 41):
    hsa-miR-576-3p hsa-miR-4254 hsa-miR-24-1* hsa-miR-106a hsa-miR-1224-3p hsa-miR-1260b hsa-miR-301a hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidRACGAP1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RACGAP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RACGAP1 About   (see all 15)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Adaptive Immune System0.56
    2Rho GTPase cycle
    Signaling by Rho GTPases1.00
    Rho GTPase cycle1.00
    3MHC class II antigen presentation
    MHC class II antigen presentation0.32
    Kinesins0.32
    4G-protein signaling Regulation of RAC1 activity
    G-protein signaling Regulation of RAC1 activity0.88
    5Apoptotic Pathways in Synovial Fibroblasts
    Rac1 Pathway0.65

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for RACGAP1
        G-protein signaling Rac2 regulation pathway
    G-protein signaling Regulation of RAC1 activity

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RACGAP1
        Rac1 Pathway

    2 GeneGo (Thomson Reuters) Pathways for RACGAP1
        G-protein signaling Regulation of RAC1 activity
    G-protein signaling Rac2 regulation pathway

    5/6 BioSystems Pathways for RACGAP1 (see all 6)
        Wnt Signaling Pathway and Pluripotency
    Signal Transduction of S1P Receptor
    Aurora B signaling
    Regulation of CDC42 activity
    Regulation of RAC1 activity

    5/9        Reactome Pathways for RACGAP1 (see all 9)
        Hemostasis
    Signaling by Rho GTPases
    Adaptive Immune System
    Rho GTPase cycle
    Factors involved in megakaryocyte development and platelet production



    RACGAP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RACGAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/845 Interacting proteins for RACGAP1 (Q9H0H51, 2, 3 ENSP000003098714) via UniProtKB, MINT, STRING, and/or I2D (see all 845)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2R5EQ165372, 3, ENSP000003376414MINT-6166710 MINT-6166735 MINT-6166596 MINT-6166691 MINT-6166659 MINT-6166727 I2D: score=2 STRING: ENSP00000337641
    KIF23Q022412, 3, ENSP000002603634MINT-6799707 MINT-8397862 MINT-8400617 MINT-6166596 MINT-8397624 MINT-8397899 I2D: score=1 STRING: ENSP00000260363
    PPP2CAP677752, 3, ENSP000004184474MINT-6166596 MINT-6166653 I2D: score=2 STRING: ENSP00000418447
    TUBA4AP683662, 3, ENSP000002484374MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000248437
    YWHABP319462, 3, ENSP000003001614MINT-50978 I2D: score=4 STRING: ENSP00000300161
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis IMP16236794
    GO:0000915cytokinesis, actomyosin contractile ring assembly IMP16129829
    GO:0007018microtubule-based movement TAS--
    GO:0007108cytokinesis, initiation of separation IMP16129829
    GO:0007165signal transduction ----

    RACGAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RACGAP1 (RGAP1)

    10/843 HMDB Compounds for RACGAP1 (see all 843)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----
    DG(14:0/18:3(6Z,9Z,12Z)/0:0)Diacylglycerol(14:0/18:3n6) (see all 16)----

    Search CenterWatch for drugs/clinical trials and news about RACGAP1 / RGAP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for RACGAP1 gene (3 alternative transcripts): 
    NM_001126103.1  NM_001126104.1  NM_013277.3  

    Unigene Cluster for RACGAP1:

    Rac GTPase activating protein 1
    Hs.505469  [show with all ESTs]
    Unigene Representative Sequence: NM_001126103
    18/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):
    ENST00000548961 ENST00000427314 ENST00000312377 ENST00000454520 ENST00000551016
    ENST00000547905 ENST00000549342 ENST00000547061 ENST00000548320 ENST00000548598
    ENST00000552310 ENST00000548158 ENST00000550149 ENST00000546786 ENST00000546595
    ENST00000551145 ENST00000548824 ENST00000551260
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    Additional mRNA sequence: 

    AB030251.1 AB040911.1 AK000733.1 AK022726.1 AK225901.1 AK315785.1 AL136794.1 BC024144.2 
    BC032754.1 CR533565.1 

    15 DOTS entries:

    DT.445826  DT.100797704  DT.100797709  DT.100797710  DT.95319330  DT.100797706  DT.102830933  DT.100036361 
    DT.100728933  DT.121129817  DT.121129861  DT.92060622  DT.99942987  DT.100036360  DT.91997253 

    24/236 AceView cDNA sequences (see all 236):

    CR615917 AB040911 BG258163 BP365058 NM_013277 BM909314 CB115198 BI092422 
    BI093200 BX388364 BM455516 BX367703 BP357153 BM557222 BQ218534 BQ217059 
    AI697315 CB141439 CR603322 W61248 BG820884 W72501 BG289047 AL136794 

    GeneLoc Exon Structure

    5/19 Alternative Splicing Database (ASD) splice patterns (SP) for RACGAP1 (see all 19)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
    SP1:                                            -     -     -     -     -                                                                                       
    SP2:                                                        -     -     -                                                                                       
    SP3:                                                  -     -     -     -                                                                                       
    SP4:                                            -     -     -     -                                                                                             
    SP5:                                            -     -     -     -     -                                                                                       

    ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for RACGAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RACGAP1 expression in normal human tissues (normalized intensities)      RACGAP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAACATAGCC
    RACGAP1 Expression
    About this image


    RACGAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/19 selected tissues (see all 19) fully expand
     
     Epithelium (Reproductive System)    fully expand to see all 4 entries
             cervix, uterine ; squamous epithelial cells   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Bone marrow-derived hematopoietic stem cells
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             seminal vesicle ; glandular cells   

    See RACGAP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RACGAP1

    SOURCE GeneReport for Unigene cluster: Hs.505469

    UniProtKB/Swiss-Prot: RGAP1_HUMAN, Q9H0H5
    Tissue specificity: Highly expressed in testis, thymus and placenta. Expressed at lower levels in spleen and
    peripheral blood lymphocytes. In testis, expression is restricted to germ cells with the highest levels of
    expression found in spermatocytes. Expression is regulated in a cell cycle-dependent manner and peaks during G2/M
    phase

        SABiosciences Expression via Pathway-Focused PCR Array including RACGAP1: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RACGAP1 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Racgap11 , 5 Rac GTPase-activating protein 11, 5 84.26(n)1
    85.17(a)1
      15 (56.13 cM)5
    269341  NM_001253808.11  NP_001240737.11 
     996204965 
    chicken
    (Gallus gallus)
    Aves RACGAP11 Rac GTPase activating protein 1 74.92(n)
    79.04(a)
      426884  XM_424490.3  XP_424490.3 
    lizard
    (Anolis carolinensis)
    Reptilia RACGAP16
    --
    --
    81(a)
    36(a)
    1 ↔ 1
    possible ortholog
    2(92175914-92205951)
    1(95975892-96008016)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC530482 similar to Rac GTPase activating protein 1 74.52(n)    BC046676.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb92c082 wufb92c08 74.28(n)   323197  BC063983.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RacGAP84C3
    tum1
    limb morphogenesis RAS GTPase activator3
    tumbleweed1
    41(a)
    (best of 2)3
    46.95(n)1
    38.37(a)1
      84D33
    365381  NM_137068.31  NP_610912.21 
    worm
    (Caenorhabditis elegans)
    Secernentea cyk-41 , 3 Phorbol esters/diacylglycerol binding
    domain (C1 more3
    Protein CYK-41
    32(a)3
    41.71(n)1
    30.09(a)1
      III(13840084-13842506)3
    1768151  NM_067444.51  NP_499845.11 


    ENSEMBL Gene Tree for RACGAP1 (if available)
    TreeFam Gene Tree for RACGAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RACGAP1 gene
    ARHGAP292  SYDE22  HMHA12  ABR2  SYDE12  GMIP2  BCR2  
    3 SIMAP similar genes for RACGAP1 using alignment to 22 protein entries:     RGAP1_HUMAN (see all proteins):
    FKSG42    ARHGAP12    ARHGAP9

    RACGAP1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for RACGAP1
    PGOHUM00000239430 PGOHUM00000247791 PGOHUM00000246146


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/804 SNPs in RACGAP1 are shown (see all 804)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1505391671,2
    --50382515(+) ACTCCC/TGGTGG 3 -- ds50010--------
    rs1394983431,2
    C--50382594(+) GAAGTA/GATTTT 3 -- ds50010--------
    rs1431910751,2
    --50382753(+) ACCACA/GCCCAG 3 -- ds50010--------
    rs1140262501,2
    C,F--50383028(+) GTCAAA/CCATTC 3 -- ut311Minor allele frequency- C:0.03WA 118
    rs1461764931,2
    C--50383120(+) TTCCAC/TGGGAA 3 -- ut310--------
    rs89871,2
    C--50383150(+) GCAAAG/AAAAAA 3 -- ut311Minor allele frequency- A:0.00NA 2
    rs1903562251,2
    --50383175(+) TCTTAC/TCACAA 3 -- ut310--------
    rs1394469441,2
    C--50383286(+) TGGGGG/TTATGG 3 -- ut310--------
    rs1816791111,2
    --50383287(+) GGGGGA/TATGGG 3 -- ut310--------
    rs74859211,2
    C--50383327(+) AAAGAA/CAAACT 3 -- ut31 trp30--------

    HapMap Linkage Disequilibrium report for RACGAP1 (50370706 - 50426919 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RACGAP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1766563CNV Insertion17803354
    esv271791CNV Insertion20981092
    esv1010880CNV Insertion20482838
    nsv832407CNV Loss17160897
    nsv522972CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604980    OMIM disorders: --

    3 diseases for RACGAP1:    About MalaCards
    neuronitis    endotheliitis    breast cancer


    RACGAP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RACGAP1
    Human Genome Epidemiology (HuGE) Navigator: RACGAP1 (3 documents)

    Export disorders for RACGAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RACGAP1 gene, integrated from 9 sources (see all 88):
    (articles sorted by number of sources associating them with RACGAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cells. (PubMed id 9497316)1, 2, 3, 9 Toure A....Gacon G. (1998)
    2. Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells. (PubMed id 12590651)1, 2, 9 Naud N.... Gacon G. (2003)
    3. MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis. (PubMed id 16129829)1, 2, 9 Zhao W.-M. and Fang G. (2005)
    4. Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. (PubMed id 19468302)1, 2, 9 Burkard M.E....Jallepalli P.V. (2009)
    5. Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase. (PubMed id 14744859)1, 2, 9 Ban R.... Tanaka H. (2004)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis. (PubMed id 18511905)1, 2 Simon G.C....Prekeris R. (2008)
    8. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    9. Dissecting the role of Rho-mediated signaling in contractile ring formation. (PubMed id 16236794)1, 2 Kamijo K....Miki T. (2006)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29127 HGNC: 9804 AceView: RACGAP1 Ensembl:ENSG00000161800 euGenes: HUgn29127
    ECgene: RACGAP1 H-InvDB: RACGAP1

    (According to HUGE)
    About This Section
    HUGE: KIAA1478

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RACGAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RACGAP1 gene:
    Search GeneIP for patents involving RACGAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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