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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAC3 Gene

protein-coding   GIFtS: 65
GCID: GC17P079989

Ras-Related C3 Botulinum Toxin Substrate 3 (Rho Family,...

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ras-Related C3 Botulinum Toxin Substrate 3 (Rho Family, Small GTP
Binding Protein Rac3)1 2
p21-Rac32 3
Ras-Related C3 Botulinum Toxin Substrate 32
Rho Family, Small GTP Binding Protein Rac32

External Ids:    HGNC: 98031   Entrez Gene: 58812   Ensembl: ENSG000001697507   OMIM: 6020505   UniProtKB: P607633   

Export aliases for RAC3 gene to outside databases

Previous GC identifers: GC17P079412 GC17P9J0031 GC17P080525 GC17P077582 GC17P075389


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAC3 Gene:
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins.
Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell
growth, cytoskeletal reorganization, and the activation of protein kinases. (provided by RefSeq, Jul 2008)

GeneCards Summary for RAC3 Gene: 
RAC3 (ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)) is a protein-coding gene. Diseases associated with RAC3 include myocarditis, and vascular disease, and among its related super-pathways are Focal Adhesion and Regulation of actin cytoskeleton. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOH.

UniProtKB/Swiss-Prot: RAC3_HUMAN, P60763
Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound
state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell
spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles

summary for RAC3 Gene:
Small G proteins (small GTPases) are homologous to Galpha proteins and are often referred to as the Ras
proto-oncogene superfamily. The Ras superfamily contains over 100 small GTPases grouped into eight families;
Ras, Rho, Rab, Rap, Arf, Ran, Rheb and Rad. Small GTPases regulate a wide variety of processes in the cell,
including growth, differentiation, movement and lipid vesicle transport. Like Galpha proteins, small GTPases
alternate between an 'on' state (bound to GTP) and an 'off' state (bound to GDP). This cyclic process
requires guanine nucleotide exchange factor (GEF) and GTPase-activating protein (GAP). Small GTPases are the
downstream effectors of most receptor tyrosine kinases (RTKs) and are linked via two proteins, GRB2 and SOS.
They are coupled to intracellular signaling cascades including the MAPK pathway, through interactions with
Raf kinase. Normally, activation of small GTPases is induced by ligand binding to a RTK. In many transformed
cells activating mutations of GTPases, often Ras, produce a cellular response in the absence of a ligand,
thus promoting malignant progression.

Gene Wiki entry for RAC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010663.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAC3 gene promoter:
         PPAR-gamma1   STAT1   AP-1   p300   STAT3   STAT5A   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAC3 promoter sequence
   Search SABiosciences Chromatin IP Primers for RAC3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

RAC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAC3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P079989:  view genomic region     (about GC identifiers)

Start:
79,989,500 bp from pter      End:
79,992,080 bp from pter
Size:
2,581 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RAC3_HUMAN, P60763 (See protein sequence)
Recommended Name: Ras-related C3 botulinum toxin substrate 3 precursor  
Size: 192 amino acids; 21379 Da
Subunit: Interacts with the GEF protein DOCK7, which promotes the exchange between GDP and GTP, and therefore
activates it. Interacts with C1D
Subcellular location: Cytoplasm. Endomembrane system. Cell projection, lamellipodium. Note=Membrane-associated
when activated. Co-localizes with NRBP to endomembranes and at the cell periphery in lamellipodia
5 PDB 3D structures from and Proteopedia for RAC3:
2C2H (3D)        2G0N (3D)        2IC5 (3D)        2OV2 (3D)        2QME (3D)    
Secondary accessions: O14658 Q5U0M8

Explore the universe of human proteins at neXtProt for RAC3: NX_P60763

Explore proteomics data for RAC3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P60763

  • RAC3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAC3 Protein Expression
    REFSEQ proteins: NP_005043.1  
    ENSEMBL proteins: 
     ENSP00000304283   ENSP00000463590   ENSP00000462421  
    Reactome Protein details: P60763
    Human Recombinant Protein Products for RAC3: 
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    ProSpec Recombinant Protein for RAC3
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0012505endomembrane system IDA11956649
    GO:0016020membrane ----

    RAC3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P60763

    ProtoNet protein and cluster: P60763

    1 Blocks protein domain: IPB003577 Ras small GTPase

    UniProtKB/Swiss-Prot: RAC3_HUMAN, P60763
    Similarity: Belongs to the small GTPase superfamily. Rho family


    RAC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAC3_HUMAN, P60763
    Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound
    state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell
    spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles
    Induction: Expression down-regulated in quiescent fibroblasts and clearly induced by serum stimulation

         Genatlas biochemistry entry for RAC3:
    ras-related C3 botulinism toxin substrate 3,Ras-like protein 2,member of the Rho family of GTPase,specifically
    expressed in hemopoietic lineage,involved in the production of superoxide in neutrophils,putative regulator of
    mitogen-induced cytoskeletal changes,essential for membrane ruffling and C-jun aminoterminal kinase JNK,key
    downstream target in Ras signaling putatively mediated by EPS58 and SSH3BP1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA11956649
    GO:0005515protein binding IPI11956649
    GO:0005525GTP binding IEA--
         
    RAC3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RAC3:
     Decreased focal adhesion (FA)  

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rac3):
     behavior/neurological  hematopoietic system  integument  mortality/aging  nervous system 
     tumorigenesis 

    RAC3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rac3tm1Hkp for RAC3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RAC3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RAC3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAC3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAC3 

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    SwitchGear 3'UTR luciferase reporter plasmidRAC3 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAC3 About   (see all 46)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal Adhesion0.64
    Integrin-mediated cell adhesion0.38
    Focal adhesion0.64
    2Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    3Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway0.40
    4Integrin Pathway
    Integrin Pathway0.67
    GnRH Signaling0.56
    FAK1 Signaling0.67
    Transendothelial Migration of Leukocytes0.38
    5GPCR Pathway
    Ras Pathway0.73
    Pancreatic Adenocarcinoma0.59
    GPCR Pathway0.62
    Breast Cancer Regulation by Stathmin10.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for RAC3
        Wnt Signaling Pathway

    5/50 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RAC3 (see all 50)
        Fc-GammaR Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    G12-G13 in Cellular Signaling
    TRKA Signaling

    2 Cell Signaling Technology (CST) Pathways for RAC3
        MAP Kinase Signaling
    Cytoskeletal Signaling

    5 BioSystems Pathways for RAC3
        Focal Adhesion
    DNA damage response (only ATM dependent)
    Integrin-mediated cell adhesion
    RalA downstream regulated genes
    Regulation of Actin Cytoskeleton

    3        Reactome Pathways for RAC3
        Signaling by Rho GTPases
    Signal Transduction
    Rho GTPase cycle

    1 PharmGKB Pathway for RAC3
        Bisphosphonate Pathway, Pharmacodynamics

    5/14         Kegg Pathways  (Kegg details for RAC3) (see all 14):
        MAPK signaling pathway
    Wnt signaling pathway
    Axon guidance
    VEGF signaling pathway
    Focal adhesion


    RAC3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/156 Interacting proteins for RAC3 (P607631, 2, 3 ENSP000003042834) via UniProtKB, MINT, STRING, and/or I2D (see all 156)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NRBP1Q9UHY11, 3, ENSP000002335574EBI-767084,EBI-749731 I2D: score=2 STRING: ENSP00000233557
    ARHGDIAP525652, 3, ENSP000002693214MINT-8267929 I2D: score=3 STRING: ENSP00000269321
    ARHGDIBP525662, 3, ENSP000002289454MINT-8267940 I2D: score=3 STRING: ENSP00000228945
    CIB1Q998283, ENSP000003338734I2D: score=3 STRING: ENSP00000333873
    ANKRD11Q6UB993, ENSP000003010304I2D: score=1 STRING: ENSP00000301030
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process IDA11956649
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0015031protein transport ----
    GO:0030031cell projection assembly IDA11956649

    RAC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for RAC3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    QS 11ARFGAP1 inhibitor; modulates Wnt/beta-catenin signaling[944328-88-5]
    NSC 23766Selective inhibitor of Rac1-GEF interaction; antioncogenic[733767-34-5]
    EHT 1864Potent inhibitor of Rac family GTPases[754240-09-0]
    SecinH3Sec7-specific GEF inhibitor (cytohesins)[853625-60-2]
    Rac1 Inhibitor W56Selective inhibitor of Rac1-GEF interaction[1095179-01-3]

    1 HMDB Compound for RAC3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about RAC3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAC3 gene: 
    NM_005052.2  

    Unigene Cluster for RAC3:

    Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
    Hs.45002  [show with all ESTs]
    Unigene Representative Sequence: BM561442
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306897(uc002kdf.3) ENST00000580965 ENST00000584341 ENST00000585014

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF008591.1 AF498966.1 BC009605.1 BC015197.1 BT019443.1 

    3 DOTS entries:

    DT.440864  DT.92421250  DT.97784439 

    24/38 AceView cDNA sequences (see all 38):

    C00214 AV709850 CB139771 T08497 BM708296 AF498966 AI570572 NM_005052 
    AF008591 BI914032 BI668056 T08498 BM795747 BI462860 BC015197 BM841195 
    AI347327 AA311931 BC009605 AW193655 AI937293 BE958199 BU731383 BG527859 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RAC3    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
    SP1:              -     -           -           -                                 
    SP2:              -     -           -           -                                 
    SP3:                                -           -                                 
    SP4:                                            -                                 
    SP5:                                                                              


    ECgene alternative splicing isoforms for RAC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAC3 expression in normal human tissues (normalized intensities)      RAC3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGATGAGGC
    RAC3 Expression
    About this image


    RAC3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)
             Dorsal Horn   

    See RAC3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAC3

    SOURCE GeneReport for Unigene cluster: Hs.45002

    UniProtKB/Swiss-Prot: RAC3_HUMAN, P60763
    Tissue specificity: Highest levels in brain, also detected in heart, placenta and pancreas

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAC3 gene from 8/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rac31 , 5 RAS-related C3 botulinum substrate 31, 5 89.41(n)1
    100(a)1
      11 (84.46 cM)5
    1707581  NM_133223.41  NP_573486.11 
     1207214705 
    chicken
    (Gallus gallus)
    Aves RAC31 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) less 82.12(n)
    98.96(a)
      395870  NM_205016.1  NP_990347.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAC36
    Uncharacterized protein
    99(a)
    1 ↔ 1
    2(118197926-118205548)
    zebrafish
    (Danio rerio)
    Actinopterygii rac3a1 ras-related C3 botulinum toxin substrate 3a (rho family, small GTP binding protein Rac3) less 79.17(n)
    97.92(a)
      437027  NM_001002754.1  NP_001002754.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rac11 , 3 cell proliferation GTPase3
    CG2248-PA1
    89(a)
    (best of 4)3
    80.8(n)1
    89.53(a)1
      3 61F53
    381461  NM_057602.31  NP_476950.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ced-103 RAS-related protein 97(a)
    (best of 4)
      IV(3507381-3509495)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RAC21 Rac-like GTP-binding protein ARAC2 58.61(n)
    66.29(a)
      834637  NM_123965.1  NP_199409.1 
    rice
    (Oryza sativa)
    Liliopsida AK069443.12   -- 76.92(n)    AK069443.1 


    ENSEMBL Gene Tree for RAC3 (if available)
    TreeFam Gene Tree for RAC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAC3 gene
    RHOH2  RHOQ2  RHOBTB12  RHOV2  RHOU2  RHOG2  RHOBTB22  RAC12  
    RAC22  CDC422  RHOJ2  
    18/39 SIMAP similar genes for RAC3 using alignment to 3 protein entries:     RAC3_HUMAN (see all proteins) (see all similar genes):
    RAC2    RAC1    CDC42    ARHG    RHOG    RHOJ
    RHOQ    RHOA    RHOF    RHOV    RHOC    RHOD
    RHOB    RHOU    RND2    RHOH    ARHE    RND3

    RAC3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/123 SNPs in RAC3 are shown (see all 123)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1904081191,2
    --79989546(+) CCGATC/TGCTCG 1 -- ut510--------
    rs1826960871,2
    --79989605(+) GGCTCC/GCGGCC 1 -- ut510--------
    rs1869652621,2
    --79989870(+) AGCTCG/TGGCCC 1 -- int10--------
    rs1923525851,2
    --79989877(+) GCCCAC/TCTGAT 1 -- int10--------
    rs45178561,2
    C,F--79989976(+) GCTGAA/TCCCTC 1 -- int11Minor allele frequency- T:0.12NA 120
    rs1826020511,2
    --79990142(+) GGCTGA/GGTCCC 1 -- int10--------
    rs1457961871,2
    C--79990418(+) TGGGC-/TT    
       CCACG
    TTCCA
    1 -- int10--------
    rs1888533931,2
    --79990480(+) TGGCCA/GGAGTT 1 -- int10--------
    rs49694771,2
    C,F,H--79990481(+) GGCCAG/AAGTTC 1 -- int120Minor allele frequency- A:0.04NS EA NA WA CSA 2342
    rs761311341,2
    --79990522(+) CACAGA/GCCAGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for RAC3 (79989500 - 79992080 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/26 variations for RAC3 (see all 26):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv909134CNV Loss21882294
    dgv3349n71CNV Loss21882294
    dgv3346n71CNV Loss21882294
    dgv3341n71CNV Loss21882294
    dgv3333n71CNV Loss21882294
    nsv909161CNV Loss21882294
    dgv3340n71CNV Loss21882294
    dgv3332n71CNV Loss21882294
    dgv3344n71CNV Loss21882294
    nsv457975CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602050    OMIM disorders: --

    14 diseases for RAC3:    About MalaCards
    myocarditis    vascular disease    pancreatic cancer    breast cancer
    lymphoblastic leukemia    prostatitis    colorectal cancer    pancreatitis
    gastric cancer    prostate cancer    adenocarcinoma    neuronitis
    lung cancer    leukemia

    2 diseases from the University of Copenhagen DISEASES database for RAC3:
    Cancer     Vascular disease

    RAC3 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for RAC3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 30.2 9 10618392 (2), 16280046 (2), 9252344 (1), 19269969 (1) (see all 5)
    cancer 22 4 10618392 (1), 16267012 (1)
    gastric cancer 15.6 2 14575565 (1), 14975755 (1)
    metastasis 8.4 1 17639041 (1)
    tumors 0 10 10618392 (2), 15993075 (2), 17639041 (2)


    Export disorders for RAC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAC3 gene, integrated from 9 sources (see all 55):
    (articles sorted by number of sources associating them with RAC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of RAC3, a novel member of the Rho family. (PubMed id 9252344)1, 2, 9 Haataja L.... Heisterkamp N. (1997)
    2. Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. (PubMed id 11956649)1, 2, 9 De Langhe S.... Heisterkamp N. (2002)
    3. The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18. (PubMed id 16982419)1, 2 Watabe-Uchida M.... Van Aelst L. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Expression of Rac3 in human brain tumors. (PubMed id 15993075)1, 9 Hwang S.L....Hong Y.R. (2005)
    6. Rac1 and Rac3 have opposing functions in cell adhesion and differentiation of neuronal cells. (PubMed id 17244648)1, 9 Hajdo-Milasinovic A....Collard J.G. (2007)
    7. Rac3 inhibits adhesion and differentiation of neurona l cells by modifying GIT1 downstream signaling. (PubMed id 19494130)1, 9 Hajdo-Milasinovic A....Collard J.G. (2009)
    8. Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway. (PubMed id 10618392)1, 9 Mira J.P....Knaus U.G. (2000)
    9. Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells. (PubMed id 16280046)1, 9 Baugher P.J....Dharmawardhane S.F. (2005)
    10. The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading. (PubMed id 11756406)1, 9 Haataja L....Heisterkamp N. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5881 HGNC: 9803 AceView: RAC3 Ensembl:ENSG00000169750 euGenes: HUgn5881
    ECgene: RAC3 Kegg: 5881 H-InvDB: RAC3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAC3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAC3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAC3 gene:
    Search GeneIP for patents involving RAC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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