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Aliases for RAC3 Gene

Aliases for RAC3 Gene

  • Ras-Related C3 Botulinum Toxin Substrate 3 (Rho Family, Small GTP Binding Protein Rac3) 2 3
  • P21-Rac3 3 4
  • Rho Family, Small GTP Binding Protein Rac3 3

External Ids for RAC3 Gene

Previous GeneCards Identifiers for RAC3 Gene

  • GC17P079412
  • GC17P9J0031
  • GC17P080525
  • GC17P077582
  • GC17P079989
  • GC17P075389

Summaries for RAC3 Gene

Entrez Gene Summary for RAC3 Gene

  • The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

GeneCards Summary for RAC3 Gene

RAC3 (Ras-Related C3 Botulinum Toxin Substrate 3 (Rho Family, Small GTP Binding Protein Rac3)) is a Protein Coding gene. Diseases associated with RAC3 include amyotrophic lateral sclerosis type 2 and caroli disease. Among its related pathways are MAPK signaling pathway and Signaling by GPCR. GO annotations related to this gene include GTP binding and calcium-dependent protein binding. An important paralog of this gene is RAC2.

UniProtKB/Swiss-Prot for RAC3 Gene

  • Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner.

Tocris Summary for RAC3 Gene

  • Small G proteins (small GTPases) are homologous to Galpha proteins and are often referred to as the Ras proto-oncogene superfamily. Small GTPases regulate a wide variety of processes in the cell, including growth, differentiation, movement and lipid vesicle transport.

Gene Wiki entry for RAC3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAC3 Gene

Genomics for RAC3 Gene

Regulatory Elements for RAC3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAC3 Gene

Chromosome:
17
Start:
82,031,624 bp from pter
End:
82,034,204 bp from pter
Size:
2,581 bases
Orientation:
Plus strand

Genomic View for RAC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAC3 Gene

Proteins for RAC3 Gene

  • Protein details for RAC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60763-RAC3_HUMAN
    Recommended name:
    Ras-related C3 botulinum toxin substrate 3
    Protein Accession:
    P60763
    Secondary Accessions:
    • O14658
    • Q5U0M8

    Protein attributes for RAC3 Gene

    Size:
    192 amino acids
    Molecular mass:
    21379 Da
    Quaternary structure:
    • Interacts with the GEF protein DOCK7, which promotes the exchange between GDP and GTP, and therefore activates it. Interacts with C1D. Interacts (via C-terminal region) with CIB1; the interaction induces their association with the cytoskeleton upon alpha-IIb/beta3 integrin-mediated adhesion.

    Three dimensional structures from OCA and Proteopedia for RAC3 Gene

neXtProt entry for RAC3 Gene

Proteomics data for RAC3 Gene at MOPED

Post-translational modifications for RAC3 Gene

  • Ubiquitination at Lys 153
  • Modification sites at PhosphoSitePlus

Other Protein References for RAC3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RAC3 (RAC3)

No data available for DME Specific Peptides for RAC3 Gene

Domains & Families for RAC3 Gene

Gene Families for RAC3 Gene

Protein Domains for RAC3 Gene

Suggested Antigen Peptide Sequences for RAC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60763

UniProtKB/Swiss-Prot:

RAC3_HUMAN :
  • Belongs to the small GTPase superfamily. Rho family.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RAC3: view

Function for RAC3 Gene

Molecular function for RAC3 Gene

GENATLAS Biochemistry:
ras-related C3 botulinism toxin substrate 3,Ras-like protein 2,member of the Rho family of GTPase,specifically expressed in hemopoietic lineage,involved in the production of superoxide in neutrophils,putative regulator of mitogen-induced cytoskeletal changes,essential for membrane ruffling and C-jun aminoterminal kinase JNK,key downstream target in Ras signaling putatively mediated by EPS58 and SSH3BP1
UniProtKB/Swiss-Prot Function:
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner.
UniProtKB/Swiss-Prot Induction:
Expression down-regulated in quiescent fibroblasts and clearly induced by serum stimulation

Gene Ontology (GO) - Molecular Function for RAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 11956649
GO:0005515 protein binding IPI 11956649
GO:0005525 GTP binding IEA --
GO:0048306 calcium-dependent protein binding IPI 11756406
genes like me logo Genes that share ontologies with RAC3: view
genes like me logo Genes that share phenotypes with RAC3: view

Animal Models for RAC3 Gene

MGI Knock Outs for RAC3:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAC3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for RAC3 Gene

Localization for RAC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAC3 Gene

Cytoplasm. Endomembrane system. Cell projection, lamellipodium. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton. Note=Membrane-associated when activated. Colocalizes with NRBP to endomembranes and at the cell periphery in lamellipodia. Colocalized with CIB1 in the perinuclear area and at the cell periphery.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAC3 Gene COMPARTMENTS Subcellular localization image for RAC3 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
plasma membrane 5
cytosol 4
endosome 2
mitochondrion 2
nucleus 2
vacuole 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for RAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0012505 endomembrane system IDA 11956649
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RAC3: view

Pathways & Interactions for RAC3 Gene

genes like me logo Genes that share pathways with RAC3: view

SIGNOR curated interactions for RAC3 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for RAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0014041 regulation of neuron maturation IEA --
GO:0015031 protein transport --
GO:0021894 cerebral cortex GABAergic interneuron development IEA --
genes like me logo Genes that share ontologies with RAC3: view

Drugs & Compounds for RAC3 Gene

(4) Drugs for RAC3 Gene - From: Tocris, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
EHop-016 Pharma Rac1/Rac3 GTPase inhibitor,potent and specific 0
EHT 1864 Pharma Rac family small GTPases inhibitor, Potent inhibitor of Rac family GTPases 0
NSC 23766 Pharma Selective inhibitor of Rac1-GEF interaction., Selective inhibitor of Rac1-GEF interaction; antioncogenic 0

(3) Additional Compounds for RAC3 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
QS 11
944328-88-5
Rac1 Inhibitor W56
1095179-01-3
SecinH3
853625-60-2
genes like me logo Genes that share compounds with RAC3: view

Transcripts for RAC3 Gene

Unigene Clusters for RAC3 Gene

Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAC3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAC3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - - - -
SP2: - - - -
SP3: - -
SP4: -
SP5:

Relevant External Links for RAC3 Gene

GeneLoc Exon Structure for
RAC3
ECgene alternative splicing isoforms for
RAC3

Expression for RAC3 Gene

mRNA expression in normal human tissues for RAC3 Gene

mRNA differential expression in normal tissues according to GTEx for RAC3 Gene

This gene is overexpressed in Brain - Cerebellum (x4.9) and Brain - Cerebellar Hemisphere (x4.6).

Protein differential expression in normal tissues from HIPED for RAC3 Gene

This gene is overexpressed in Brain (26.7), Fetal Brain (20.7), and Frontal cortex (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAC3 Gene



SOURCE GeneReport for Unigene cluster for RAC3 Gene Hs.45002

mRNA Expression by UniProt/SwissProt for RAC3 Gene

P60763-RAC3_HUMAN
Tissue specificity: Highest levels in brain, also detected in heart, placenta and pancreas
genes like me logo Genes that share expression patterns with RAC3: view

Protein tissue co-expression partners for RAC3 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for RAC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAC3 35
  • 91.49 (n)
  • 100 (a)
RAC3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rac3 35
  • 89.41 (n)
  • 100 (a)
Rac3 16
Rac3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rac3 35
  • 89.26 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia RAC3 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 92 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia RAC3 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAC3 35
  • 82.12 (n)
  • 98.96 (a)
RAC3 36
  • 98 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 99 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rac3 35
  • 79.69 (n)
  • 96.87 (a)
zebrafish
(Danio rerio)
Actinopterygii rac3a 35
  • 79.17 (n)
  • 97.92 (a)
rac3b 36
  • 96 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Mtl 37
  • 68 (a)
Rac1 37
  • 89 (a)
Rac2 37
  • 86 (a)
RhoL 37
  • 54 (a)
Rac1 36
  • 89 (a)
ManyToMany
Rac2 36
  • 86 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ced-10 37
  • 97 (a)
F22E12.2 37
  • 47 (a)
mig-2 37
  • 65 (a)
Y32F6B.3 37
  • 43 (a)
ced-10 35
  • 69.3 (n)
  • 84.75 (a)
mig-2 36
  • 63 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons RAC2 35
  • 58.87 (n)
  • 66.67 (a)
rice
(Oryza sativa)
Liliopsida Os02g0312600 35
  • 64.55 (n)
  • 65.9 (a)
corn
(Zea mays)
Liliopsida Zm.289 35
Species with no ortholog for RAC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAC3 Gene

ENSEMBL:
Gene Tree for RAC3 (if available)
TreeFam:
Gene Tree for RAC3 (if available)

Paralogs for RAC3 Gene

Paralogs for RAC3 Gene

genes like me logo Genes that share paralogs with RAC3: view

Variants for RAC3 Gene

Sequence variations from dbSNP and Humsavar for RAC3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs4517856 -- 82,032,100(+) GCTGA(A/T)CCCTC intron-variant
rs4969477 -- 82,032,605(+) GGCCA(A/G)AGTTC intron-variant
rs4969478 -- 82,033,727(+) TCAGC(C/T)CTGAC reference, synonymous-codon, missense
rs4969479 -- 82,034,234(+) TTCTG(C/T)CCTGG downstream-variant-500B
rs4969480 -- 82,034,541(+) GGGCC(A/G)GTTCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RAC3 Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
dgv3333n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
dgv3337n71 CNV Loss 21882294
dgv3339n71 CNV Loss 21882294
nsv909151 CNV Gain+Loss 21882294
dgv3340n71 CNV Loss 21882294
dgv3341n71 CNV Loss 21882294
nsv909160 CNV Gain 21882294
nsv909161 CNV Loss 21882294
dgv3343n71 CNV Loss 21882294
nsv909166 CNV Loss 21882294
nsv457975 CNV Loss 19166990
nsv909167 CNV Gain+Loss 21882294
dgv3344n71 CNV Loss 21882294
dgv3345n71 CNV Loss 21882294
dgv3346n71 CNV Loss 21882294
dgv3347n71 CNV Loss 21882294
dgv3348n71 CNV Loss 21882294
nsv909181 CNV Loss 21882294
dgv3349n71 CNV Loss 21882294

Variation tolerance for RAC3 Gene

Residual Variation Intolerance Score: 23.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAC3 Gene

HapMap Linkage Disequilibrium report
RAC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAC3 Gene

Disorders for RAC3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RAC3 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis type 2
  • amyotrophic lateral sclerosis 2, juvenile
caroli disease
  • caroli disease isolated
breast cancer
  • breast cancer, invasive ductal
- elite association
Search RAC3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RAC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAC3
genes like me logo Genes that share disorders with RAC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAC3 Gene

Publications for RAC3 Gene

  1. Rac3 inhibits adhesion and differentiation of neuronal cells by modifying GIT1 downstream signaling. (PMID: 19494130) Hajdo-Milasinovic A. … Collard J.G. (J. Cell. Sci. 2009) 23 67
  2. Silencing of D4-GDI inhibits growth and invasive behavior in MDA-MB-231 cells by activation of Rac-dependent p38 and JNK signaling. (PMID: 19269969) Zhang Y. … Zhang B. (J. Biol. Chem. 2009) 23 67
  3. Deaf-1 regulates epithelial cell proliferation and side-branching in the mammary gland. (PMID: 18826651) Barker H.E. … Visvader J.E. (BMC Dev. Biol. 2008) 23 67
  4. PAK is required for the disruption of E-cadherin adhesion by the small GTPase Rac. (PMID: 18319303) Lozano E. … Braga V.M. (J. Cell. Sci. 2008) 23 67
  5. Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. (PMID: 17932039) Shutes A. … Der C.J. (J. Biol. Chem. 2007) 23 67

Products for RAC3 Gene

  • Addgene plasmids for RAC3

Sources for RAC3 Gene

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