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Aliases for RAC3 Gene

Aliases for RAC3 Gene

  • Ras-Related C3 Botulinum Toxin Substrate 3 (Rho Family, Small GTP Binding Protein Rac3) 2 3
  • P21-Rac3 3 4
  • Ras-Related C3 Botulinum Toxin Substrate 3 3
  • Rho Family, Small GTP Binding Protein Rac3 3

External Ids for RAC3 Gene

Summaries for RAC3 Gene

Entrez Gene Summary for RAC3 Gene

  • The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAC3 Gene

RAC3 (Ras-Related C3 Botulinum Toxin Substrate 3 (Rho Family, Small GTP Binding Protein Rac3)) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Ras signaling pathway. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAC2.

UniProtKB/Swiss-Prot for RAC3 Gene

  • Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner.

Tocris Summary for RAC3 Gene

  • Small G proteins (small GTPases) are homologous to Galpha proteins and are often referred to as the Ras proto-oncogene superfamily. The Ras superfamily contains over 100 small GTPases grouped into eight families; Ras, Rho, Rab, Rap, Arf, Ran, Rheb and Rad. Small GTPases regulate a wide variety of processes in the cell, including growth, differentiation, movement and lipid vesicle transport. Like Galpha proteins, small GTPases alternate between an on state (bound to GTP) and an off state (bound to GDP). This cyclic process requires guanine nucleotide exchange factor (GEF) and GTPase-activating protein (GAP). Small GTPases are the downstream effectors of most receptor tyrosine kinases (RTKs) and are linked via two proteins, GRB2 and SOS. They are coupled to intracellular signaling cascades including the MAPK pathway, through interactions with Raf kinase. Normally, activation of small GTPases is induced by ligand binding to a RTK. In many transformed cells activating mutations of GTPases, often Ras, produce a cellular response in the absence of a ligand, thus promoting malignant progression.

Gene Wiki entry for RAC3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAC3 Gene

Genomics for RAC3 Gene

Genomic Location for RAC3 Gene

Start:
82,031,624 bp from pter
End:
82,034,204 bp from pter
Size:
2,581 bases
Orientation:
Plus strand

Genomic View for RAC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAC3 Gene

Regulatory Elements for RAC3 Gene

Proteins for RAC3 Gene

  • Protein details for RAC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60763-RAC3_HUMAN
    Recommended name:
    Ras-related C3 botulinum toxin substrate 3
    Protein Accession:
    P60763
    Secondary Accessions:
    • O14658
    • Q5U0M8

    Protein attributes for RAC3 Gene

    Size:
    192 amino acids
    Molecular mass:
    21379 Da
    Quaternary structure:
    • Interacts with the GEF protein DOCK7, which promotes the exchange between GDP and GTP, and therefore activates it. Interacts with C1D. Interacts (via C-terminal region) with CIB1; the interaction induces their association with the cytoskeleton upon alpha-IIb/beta3 integrin-mediated adhesion.

    Three dimensional structures from OCA and Proteopedia for RAC3 Gene

neXtProt entry for RAC3 Gene

Proteomics data for RAC3 Gene at MOPED

Post-translational modifications for RAC3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys96, Lys153, and Lys166

Other Protein References for RAC3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RAC3 Gene

Domains for RAC3 Gene

Gene Families for RAC3 Gene

HGNC:

Protein Domains for RAC3 Gene

UniProtKB/Swiss-Prot:

RAC3_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rho family.:
    • P60763
genes like me logo Genes that share domains with RAC3: view

Function for RAC3 Gene

Molecular function for RAC3 Gene

GENATLAS Biochemistry: ras-related C3 botulinism toxin substrate 3,Ras-like protein 2,member of the Rho family of GTPase,specifically expressed in hemopoietic lineage,involved in the production of superoxide in neutrophils,putative regulator of mitogen-induced cytoskeletal changes,essential for membrane ruffling and C-jun aminoterminal kinase JNK,key downstream target in Ras signaling putatively mediated by EPS58 and SSH3BP1
UniProtKB/Swiss-Prot Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner.
UniProtKB/Swiss-Prot Induction: Expression down-regulated in quiescent fibroblasts and clearly induced by serum stimulation

Gene Ontology (GO) - Molecular Function for RAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 11956649
GO:0005515 protein binding IPI 11956649
GO:0005525 GTP binding IEA --
GO:0048306 calcium-dependent protein binding IPI 11756406
genes like me logo Genes that share ontologies with RAC3: view
genes like me logo Genes that share phenotypes with RAC3: view

Animal Models for RAC3 Gene

MGI Knock Outs for RAC3:

miRNA for RAC3 Gene

miRTarBase miRNAs that target RAC3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RAC3 Gene

Localization for RAC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAC3 Gene

Cytoplasm. Endomembrane system. Cell projection, lamellipodium. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton. Note=Membrane-associated when activated. Colocalizes with NRBP to endomembranes and at the cell periphery in lamellipodia. Colocalized with CIB1 in the perinuclear area and at the cell periphery.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAC3 Gene COMPARTMENTS Subcellular localization image for RAC3 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
plasma membrane 4
endosome 2
extracellular 2
mitochondrion 2
nucleus 2
golgi apparatus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0012505 endomembrane system IDA 11956649
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RAC3: view

Pathways for RAC3 Gene

genes like me logo Genes that share pathways with RAC3: view

Gene Ontology (GO) - Biological Process for RAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0008152 metabolic process IDA 11956649
GO:0015031 protein transport --
genes like me logo Genes that share ontologies with RAC3: view

Compounds for RAC3 Gene

(5) Tocris Compounds for RAC3 Gene

Compound Action Cas Number
EHT 1864 Potent inhibitor of Rac family GTPases [754240-09-0]
NSC 23766 Selective inhibitor of Rac1-GEF interaction; antioncogenic [733767-34-5]
QS 11 ARFGAP1 inhibitor; modulates Wnt/beta-catenin signaling [944328-88-5]
Rac1 Inhibitor W56 Selective inhibitor of Rac1-GEF interaction [1095179-01-3]
SecinH3 Sec7-specific GEF inhibitor (cytohesins) [853625-60-2]

(1) HMDB Compounds for RAC3 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with RAC3: view

Transcripts for RAC3 Gene

Unigene Clusters for RAC3 Gene

Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAC3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - - - -
SP2: - - - -
SP3: - -
SP4: -
SP5:

Relevant External Links for RAC3 Gene

GeneLoc Exon Structure for
RAC3
ECgene alternative splicing isoforms for
RAC3

Expression for RAC3 Gene

mRNA expression in normal human tissues for RAC3 Gene

mRNA differential expression in normal tissues according to GTEx for RAC3 Gene

This gene is overexpressed in Brain - Cerebellum (4.9) and Brain - Cerebellar Hemisphere (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAC3 Gene

SOURCE GeneReport for Unigene cluster for RAC3 Gene Hs.45002

mRNA Expression by UniProt/SwissProt for RAC3 Gene

P60763-RAC3_HUMAN
Tissue specificity: Highest levels in brain, also detected in heart, placenta and pancreas
genes like me logo Genes that share expressions with RAC3: view

Orthologs for RAC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAC3 37
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAC3 36
  • 91.49 (n)
  • 100 (a)
RAC3 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAC3 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rac3 36
  • 89.41 (n)
  • 100 (a)
Rac3 16
Rac3 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 92 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 70 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Rac3 36
  • 89.26 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RAC3 36
  • 82.12 (n)
  • 98.96 (a)
RAC3 37
  • 98 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 99 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rac3 36
  • 79.69 (n)
  • 96.87 (a)
zebrafish
(Danio rerio)
Actinopterygii rac3a 36
  • 79.17 (n)
  • 97.92 (a)
rac3b 37
  • 96 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Rac1 37
  • 89 (a)
ManyToMany
Rac2 37
  • 86 (a)
ManyToMany
Rac1 38
  • 89 (a)
RhoL 38
  • 54 (a)
Rac2 38
  • 86 (a)
Mtl 38
  • 68 (a)
worm
(Caenorhabditis elegans)
Secernentea ced-10 36
  • 69.3 (n)
  • 84.75 (a)
mig-2 37
  • 63 (a)
ManyToMany
mig-2 38
  • 65 (a)
F22E12.2 38
  • 47 (a)
Y32F6B.3 38
  • 43 (a)
ced-10 38
  • 97 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RAC2 36
  • 58.87 (n)
  • 66.67 (a)
corn
(Zea mays)
Liliopsida Zm.289 36
rice
(Oryza sativa)
Liliopsida Os02g0312600 36
  • 64.55 (n)
  • 65.9 (a)
Species with no ortholog for RAC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAC3 Gene

ENSEMBL:
Gene Tree for RAC3 (if available)
TreeFam:
Gene Tree for RAC3 (if available)

Paralogs for RAC3 Gene

Paralogs for RAC3 Gene

genes like me logo Genes that share paralogs with RAC3: view

Variants for RAC3 Gene

Sequence variations from dbSNP and Humsavar for RAC3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs4482358 -- 82,034,549(+) TCTCA(A/G)GCAGC downstream-variant-500B
rs4500809 -- 82,034,517(+) TGTCA(A/G)GGAGG downstream-variant-500B
rs4517856 -- 82,032,100(+) GCTGA(A/T)CCCTC intron-variant
rs4541142 -- 82,034,484(+) CCTCA(A/G)GCTGA downstream-variant-500B
rs4969477 -- 82,032,605(+) GGCCA(A/G)AGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAC3 Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
dgv3333n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
dgv3337n71 CNV Loss 21882294
dgv3339n71 CNV Loss 21882294
nsv909151 CNV Gain+Loss 21882294
dgv3340n71 CNV Loss 21882294
dgv3341n71 CNV Loss 21882294
nsv909160 CNV Gain 21882294
nsv909161 CNV Loss 21882294
dgv3343n71 CNV Loss 21882294
nsv909166 CNV Loss 21882294
nsv457975 CNV Loss 19166990
nsv909167 CNV Gain+Loss 21882294
dgv3344n71 CNV Loss 21882294
dgv3345n71 CNV Loss 21882294
dgv3346n71 CNV Loss 21882294
dgv3347n71 CNV Loss 21882294
dgv3348n71 CNV Loss 21882294
nsv909181 CNV Loss 21882294
dgv3349n71 CNV Loss 21882294

Relevant External Links for RAC3 Gene

HapMap Linkage Disequilibrium report
RAC3

Disorders for RAC3 Gene

(2) University of Copenhagen DISEASES for RAC3 Gene

(5) Novoseek inferred disease relationships for RAC3 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 30.2 7
cancer 22 2
gastric cancer 15.6 2
metastasis 8.4 1
tumors 0 6
genes like me logo Genes that share disorders with RAC3: view

No data available for UniProtKB/Swiss-Prot for RAC3 Gene

Publications for RAC3 Gene

  1. The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading. (PMID: 11756406) Haataja L. … Heisterkamp N. (J. Biol. Chem. 2002) 3 4 23
  2. Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. (PMID: 11956649) De Langhe S. … Heisterkamp N. (Int. J. Mol. Med. 2002) 3 4 23
  3. Characterization of RAC3, a novel member of the Rho family. (PMID: 9252344) Haataja L. … Heisterkamp N. (J. Biol. Chem. 1997) 3 4 23
  4. Identification of a novel Rac3-interacting protein C1D. (PMID: 9852280) Haataja L. … Heisterkamp N. (Int. J. Mol. Med. 1998) 4 23
  5. Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway. (PMID: 10618392) Mira J.P. … Knaus U.G. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 23

Products for RAC3 Gene

Sources for RAC3 Gene

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