RAC3 Gene
protein-coding GIFtS: 63
GCID: GC17P079989
|
|
ras-related C3 botulinum toxin substrate 3 (rho family,...
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Aliases
for RAC3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ras-Related C3 Botulinum Toxin Substrate 3 (Rho Family, Small GTP BindingProtein Rac3)1 2 | | P21-Rac31 | | Ras-Related C3 Botulinum Toxin Substrate 32 | | Rho Family, Small GTP Binding Protein Rac32 |
Export aliases for RAC3 gene to outside databasesPrevious GC identifers: GC17P079412 GC17P9J0031 GC17P080525 GC17P077582 GC17P075389 |
Summaries
for RAC3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RAC3:
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins.Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cellgrowth, cytoskeletal reorganization, and the activation of protein kinases. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RAC3_HUMAN, P60763Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-boundstate. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreadingand the formation of actin-based protusions including lamellipodia and membrane ruffles
 summary
for RAC3: Small G proteins (small GTPases) are homologous to Galpha proteins and are often referred to as the Ras
proto-oncogene superfamily. The Ras superfamily contains over 100 small GTPases grouped into eight families;
Ras, Rho, Rab, Rap, Arf, Ran, Rheb and Rad. Small GTPases regulate a wide variety of processes in the cell,
including growth, differentiation, movement and lipid vesicle transport. Like Galpha proteins, small GTPases
alternate between an 'on' state (bound to GTP) and an 'off' state (bound to GDP). This cyclic process
requires guanine nucleotide exchange factor (GEF) and GTPase-activating protein (GAP). Small GTPases are the
downstream effectors of most receptor tyrosine kinases (RTKs) and are linked via two proteins, GRB2 and SOS.
They are coupled to intracellular signaling cascades including the MAPK pathway, through interactions with
Raf kinase. Normally, activation of small GTPases is induced by ligand binding to a RTK. In many transformed
cells activating mutations of GTPases, often Ras, produce a cellular response in the absence of a ligand,
thus promoting malignant progression.
Gene Wiki entry for RAC3
|
Genomic Views
for RAC3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010663.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAC3 gene promoter:
PPAR-gamma1 STAT1 AP-1 p300 STAT3 STAT5A PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAC3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAC3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.3 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25.3RAC3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P079989: view genomic region
(about GC identifiers)
Start:
|
79,989,500 bp from pter |
End:
|
79,992,080 bp from pter |
Size:
|
2,581 bases |
Orientation:
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plus strand |
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Proteins
for RAC3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RAC3_HUMAN, P60763 (See
protein sequence)Recommended Name: Ras-related C3 botulinum toxin substrate 3 precursor Size: 192 amino acids; 21379 Da
Subunit: Interacts with the GEF protein DOCK7, which promotes the exchange between GDP and GTP, and therefore activatesit. Interacts with C1D
Subcellular location: Cytoplasm. Endomembrane system. Cell projection, lamellipodium. Note=Membrane-associated whenactivated. Co-localizes with NRBP to endomembranes and at the cell periphery in lamellipodia
5 PDB 3D structures from  and Proteopedia  for RAC3:2C2H (3D)
2G0N (3D)
2IC5 (3D)
2OV2 (3D)
2QME (3D)
Secondary accessions: O14658 Q5U0M8Explore the universe of human proteins at neXtProt for RAC3: NX_P60763
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P60763
RAC3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005043.1
ENSEMBL proteins: ENSP00000304283 ENSP00000463590 ENSP00000462421 Reactome Protein details: P60763
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
RAC3 for ontologies About GeneDecksing
RAC3 Antibody Products:
Assay Products for RAC3: |
Protein
Domains /
Families
for RAC3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAC3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P60763ProtoNet protein and cluster: P60763 1 Blocks protein family: IPB003577 Ras small GTPase
UniProtKB/Swiss-Prot: RAC3_HUMAN, P60763Similarity: Belongs to the small GTPase superfamily. Rho family |
Function
for RAC3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RAC3_HUMAN, P60763Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-boundstate. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreadingand the formation of actin-based protusions including lamellipodia and membrane rufflesInduction: Expression down-regulated in quiescent fibroblasts and clearly induced by serum stimulation Genatlas biochemistry entry for RAC3:ras-related C3 botulinism toxin substrate 3,Ras-like protein 2,member of the Rho family of GTPase,specificallyexpressed in hemopoietic lineage,involved in the production of superoxide in neutrophils,putative regulator ofmitogen-induced cytoskeletal changes,essential for membrane ruffling and C-jun aminoterminal kinase JNK,key downstreamtarget in Ras signaling putatively mediated by EPS58 and SSH3BP1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAC3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAC3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RAC3 (NM_005052) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAC3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAC3 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
RAC3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RAC3:
Animal Models:
Mouse knock-out Rac3tm1Hkp for RAC3
6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Rac3):
RAC3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RAC3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/46 super-pathways (see all 46) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | PKC-Theta Pathway | | | 2 | Integrin Pathway | | | 3 | GPCR Pathway | | | 4 | CCR3 Pathway in Eosinophils | | | 5 | PAK Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  R&D Systems Pathway for RAC3
5/50 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RAC3 (see all 50)
2 
Cell Signaling Technology (CST) Pathways for RAC3
4  BioSystems Pathways for RAC3
3 
Reactome Pathways for RAC3
1  PharmGKB Pathway for RAC3
5/14 
Kegg Pathways (Kegg details for RAC3) (see all 14):
RAC3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAC3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/156 Interacting proteins for RAC3 (P607631, 2, 3 ENSP000003042834) via UniProtKB, MINT, STRING, and/or I2D (see all 156)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
RAC3 for ontologies About GeneDecksing
|
Drugs & Compounds
for RAC3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for RAC3 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| EHT 1864 | Potent inhibitor of Rac family GTPases | -- |
1 HMDB Compound for RAC3 About this table
Search CenterWatch for drugs/clinical trials and news about RAC3
|
Transcripts
for RAC3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RAC3 gene: NM_005052.2 Unigene Cluster for RAC3: Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) Hs.45002 [show with all ESTs]Unigene Representative Sequence: BM5614424 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000306897(uc002kdf.3) ENST00000580965 ENST00000584341 ENST00000585014
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAC3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAC3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RAC3 (NM_005052) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAC3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAC3 |
Additional cDNA sequence: AF008591.1 AF498966.1 BC009605.1 BC015197.1 BT019443.1 3 DOTS entries: DT.440864 DT.92421250 DT.97784439 24/38 AceView cDNA sequences (see all 38): C00214 NM_005052 AI570572 AF498966 AF008591 T08497 AV709850 BM708296 CB139771 T08498 AI347327 BM841195 BM795747 BI914032 BI668056 BI462860 BC015197 BC009605 AA311931 AI937293 BG527859 BE958199 AW162931 AW193655
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for RAC3 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
|---|
|
| SP1: | | | | | - | | - | | | | - | | | | - | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | - | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RAC3
|
Expression
for RAC3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RAC3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGATGAGGC
About this image
See RAC3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAC3
SOURCE GeneReport for Unigene cluster: Hs.45002
UniProtKB/Swiss-Prot: RAC3_HUMAN, P60763Tissue specificity: Highest levels in brain, also detected in heart, placenta and pancreas
SABiosciences Custom PCR Arrays for RAC3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAC3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAC3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAC3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAC3 |
Orthologs
for RAC3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RAC3 gene from 7/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RAC31 |
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) less |
82.12(n)
98.96(a) |
|
395870 NM_205016.1 NP_990347.1 |
lizard
(Anolis carolinensis) |
Reptilia |
RAC36 |
-- |
99(a) |
1 ↔ 1 |
2(118197930-118205548) |
zebrafish
(Danio rerio) |
Actinopterygii |
rac3a1 |
ras-related C3 botulinum toxin substrate 3a (rho family, small GTP binding protein Rac3) less |
79.17(n)
97.92(a) |
|
437027 NM_001002754.1 NP_001002754.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Rac11 , 3 |
cell proliferation GTPase3
CG2248-PA1 |
89(a)
(best of 4)3
80.8(n)1
89.53(a)1 |
|
3 61F53
381461 NM_057602.31 NP_476950.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
ced-103 |
RAS-related protein |
97(a)
(best of 4) |
|
IV(3507381-3509495) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
RAC21 |
Rac-like GTP-binding protein ARAC2 |
58.61(n)
66.29(a) |
|
834637 NM_123965.1 NP_199409.1 |
rice
(Oryza sativa) |
Liliopsida |
AK069443.12 |
-- |
76.92(n) |
|
AK069443.1 |
ENSEMBL Gene Tree for RAC3 (if available)
TreeFam Gene Tree for RAC3 (if available) |
Paralogs
for RAC3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RAC3 gene
- RHOH2 RHOQ2 RHOBTB12 RHOV2 RHOG2 RHOU2 RHOBTB22 RAC12
- RAC22 CDC422 RHOJ2
18/39 SIMAP similar genes for RAC3 using alignment to 3 protein entries: RAC3_HUMAN (see all proteins)
(see all similar genes):RAC2 RAC1 CDC42 ARHG RHOG RHOJ
RHOQ RHOA RHOF RHOV RHOC RHOD
RHOB RHOU RND2 RHOH ARHE RND3
RAC3 for paralogs About GeneDecksing
|
Genomic Variants
for RAC3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RAC3 (79989500 - 79992080 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RAC3
2 CNVs: 30036 73078 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAC3 |
|
Disorders
/ Diseases
for RAC3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RAC3 for disorders About GeneDecksing
OMIM gene information: 602050
OMIM disorders: --
12  diseases for RAC3: About MalaCardslymphoblastic leukemia breast cancer pancreatic cancer prostate carcinoma
colorectal cancer prostatitis prostate cancer pancreatitis
leukemia carcinoma neuronitis adenocarcinoma
2 diseases from the University of Copenhagen DISEASES database for RAC3:Cancer Vascular disease 5 Novoseek disease relationships for RAC3 gene About this table
Export disorders for RAC3 gene to outside databases
|
Publications
for RAC3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RAC3 gene, integrated from 9 sources (see all 49):
(articles sorted by number of sources associating them with RAC3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of RAC3, a novel member of the Rho family. (PubMed id 9252344)1, 2, 9 Haataja L.... Heisterkamp N. (1997)
- Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. (PubMed id 11956649)1, 2, 9 De Langhe S.... Heisterkamp N. (2002)
- The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18. (PubMed id 16982419)1, 2 Watabe-Uchida M.... Van Aelst L. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Expression of Rac3 in human brain tumors. (PubMed id 15993075)1, 9 Hwang S.L....Hong Y.R. (2005)
- Rac1 and Rac3 have opposing functions in cell adhesion and differentiation of neuronal cells. (PubMed id 17244648)1, 9 Hajdo-Milasinovic A....Collard J.G. (2007)
- Rac3 inhibits adhesion and differentiation of neurona l cells by modifying GIT1 downstream signaling. (PubMed id 19494130)1, 9 Hajdo-Milasinovic A....Collard J.G. (2009)
- Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway. (PubMed id 10618392)1, 9 Mira J.P....Knaus U.G. (2000)
- Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells. (PubMed id 16280046)1, 9 Baugher P.J....Dharmawardhane S.F. (2005)
- The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading. (PubMed id 11756406)1, 9 Haataja L....Heisterkamp N. (2002)
|
External Searches for RAC3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RAC3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RAC3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAC3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RAC3 gene:
Search GeneIP for patents involving RAC3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RAC3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for RAC3 | | OriGene shRNA RFP for RAC3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAC3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAC3 | | | OriGene Protein Over-expression Lysate for RAC3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RAC3 | | OriGene 3'-UTR Clone for RAC3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAC3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAC3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RAC3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RAC3 | | OriGene Custom Protein Services for RAC3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAC3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAC3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAC3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAC3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAC3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAC3 |
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| | Antibodies & Assays for RAC3 |
| | | | Tocris compounds for RAC3 |
| |  |  |  |  | | | | | | Recombinant Protein for RAC3 |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for RAC3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAC3 |
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