Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RAC2 Gene

Aliases for RAC2 Gene

  • Ras-Related C3 Botulinum Toxin Substrate 2 (Rho Family, Small GTP Binding Protein Rac2) 2 3 5
  • Small G Protein 3 4
  • P21-Rac2 3 4
  • Gx 3 4
  • Ras-Related C3 Botulinum Toxin Substrate 3 (Rho Family, Small GTP-Binding Protein Rac2) 3
  • HSPC022 3
  • EN-7 3

External Ids for RAC2 Gene

Previous GeneCards Identifiers for RAC2 Gene

  • GC22M034235
  • GC22M035864
  • GC22M035945
  • GC22M037621
  • GC22M020586

Summaries for RAC2 Gene

Entrez Gene Summary for RAC2 Gene

  • This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]

GeneCards Summary for RAC2 Gene

RAC2 (Ras-Related C3 Botulinum Toxin Substrate 2 (Rho Family, Small GTP Binding Protein Rac2)) is a Protein Coding gene. Diseases associated with RAC2 include neutrophil immunodeficiency syndrome and chronic granulomatous disease. Among its related pathways are Adherens junction and Axon guidance. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOH.

UniProtKB/Swiss-Prot for RAC2 Gene

  • Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.

Tocris Summary for RAC2 Gene

  • Small G proteins (small GTPases) are homologous to Galpha proteins and are often referred to as the Ras proto-oncogene superfamily. Small GTPases regulate a wide variety of processes in the cell, including growth, differentiation, movement and lipid vesicle transport.

Gene Wiki entry for RAC2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAC2 Gene

Genomics for RAC2 Gene

Regulatory Elements for RAC2 Gene

Enhancers for RAC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RAC2 on UCSC Golden Path with GeneCards custom track

Promoters for RAC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RAC2 Gene

Chromosome:
22
Start:
37,225,261 bp from pter
End:
37,244,448 bp from pter
Size:
19,188 bases
Orientation:
Minus strand

Genomic View for RAC2 Gene

Genes around RAC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAC2 Gene

Proteins for RAC2 Gene

  • Protein details for RAC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15153-RAC2_HUMAN
    Recommended name:
    Ras-related C3 botulinum toxin substrate 2
    Protein Accession:
    P15153
    Secondary Accessions:
    • Q9UDJ4

    Protein attributes for RAC2 Gene

    Size:
    192 amino acids
    Molecular mass:
    21429 Da
    Quaternary structure:
    • Interacts with DOCK2, which may activate it. Interacts with S100A8 and calprotectin (S100A8/9).

    Three dimensional structures from OCA and Proteopedia for RAC2 Gene

neXtProt entry for RAC2 Gene

Proteomics data for RAC2 Gene at MOPED

Post-translational modifications for RAC2 Gene

  • (Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rac and leads to actin disassembly.
  • Ubiquitination at Lys 133, Lys 147, and Lys 153
  • Modification sites at PhosphoSitePlus

Other Protein References for RAC2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RAC2 (RAC2)

No data available for DME Specific Peptides for RAC2 Gene

Domains & Families for RAC2 Gene

Gene Families for RAC2 Gene

Suggested Antigen Peptide Sequences for RAC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15153

UniProtKB/Swiss-Prot:

RAC2_HUMAN :
  • Belongs to the small GTPase superfamily. Rho family.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RAC2: view

Function for RAC2 Gene

Molecular function for RAC2 Gene

GENATLAS Biochemistry:
ras-related C3 botulinism toxin substrate 2,Ras-like protein,member of the Rho family of GTPase,specifically expressed in hemopoietic lineage,involved in the production of superoxide in neutrophils,putative regulator of mitogen-induced cytoskeletal changes essential for membrane ruffling,and C-jun aminoterminal kinase JNK,key downstream target in Ras signaling putatively mediated by EPS58 and SSH3BP1
UniProtKB/Swiss-Prot EnzymeRegulation:
Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.
UniProtKB/Swiss-Prot Function:
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.
genes like me logo Genes that share phenotypes with RAC2: view

Human Phenotype Ontology for RAC2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for RAC2 Gene

MGI Knock Outs for RAC2:

Animal Model Products

miRNA for RAC2 Gene

miRTarBase miRNAs that target RAC2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for RAC2 Gene

Localization for RAC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAC2 Gene

Cytoplasm. Note=Membrane-associated when activated.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAC2 Gene COMPARTMENTS Subcellular localization image for RAC2 gene
Compartment Confidence
cytosol 5
extracellular 5
plasma membrane 5
nucleus 4
cytoskeleton 2
golgi apparatus 2
endoplasmic reticulum 1
endosome 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with RAC2: view

Pathways & Interactions for RAC2 Gene

genes like me logo Genes that share pathways with RAC2: view

SIGNOR curated interactions for RAC2 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for RAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006913 nucleocytoplasmic transport IEA --
GO:0007015 actin filament organization IMP 21167572
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with RAC2: view

Drugs & Compounds for RAC2 Gene

(12) Drugs for RAC2 Gene - From: DrugBank, PharmGKB, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dextromethorphan Approved Pharma Target, inhibitor 125
Doxorubicin Approved, Investigational Pharma Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1649
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(14) Additional Compounds for RAC2 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
8-Bromo-cGMP, sodium salt
51116-01-9
8-CPT-2Me-cAMP, sodium salt
634207-53-7
8-pCPT-2-O-Me-cAMP-AM
1152197-23-3
Narciclasine
29477-83-6

(5) Tocris Compounds for RAC2 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG 51116-01-9
8-CPT-2Me-cAMP, sodium salt Selective Epac activator 634207-53-7
8-pCPT-2-O-Me-cAMP-AM Selective Epac activator; cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645) 1152197-23-3
Narciclasine Antiproliferative agent; slows cell cycle progression 29477-83-6
NSC 23766 Selective inhibitor of Rac1-GEF interaction; antioncogenic 1177865-17-6

(1) ApexBio Compounds for RAC2 Gene

Compound Action Cas Number
EHop-016 Rac1/Rac3 GTPase inhibitor,potent and specific 1380432-32-5
genes like me logo Genes that share compounds with RAC2: view

Transcripts for RAC2 Gene

Unigene Clusters for RAC2 Gene

Ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAC2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for RAC2 Gene

GeneLoc Exon Structure for
RAC2
ECgene alternative splicing isoforms for
RAC2

Expression for RAC2 Gene

mRNA expression in normal human tissues for RAC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAC2 Gene

This gene is overexpressed in Whole Blood (x32.9) and Spleen (x4.1).

Protein differential expression in normal tissues from HIPED for RAC2 Gene

This gene is overexpressed in Tlymphocyte (12.0), NK cells (11.4), Neutrophil (7.9), and Monocytes (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAC2 Gene



SOURCE GeneReport for Unigene cluster for RAC2 Gene Hs.517601

mRNA Expression by UniProt/SwissProt for RAC2 Gene

P15153-RAC2_HUMAN
Tissue specificity: Hematopoietic specific.
genes like me logo Genes that share expression patterns with RAC2: view

Protein tissue co-expression partners for RAC2 Gene

- Elite partner

Primer Products

Orthologs for RAC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAC2 35
  • 92.36 (n)
  • 98.44 (a)
RAC2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAC2 35
  • 90.62 (n)
  • 97.92 (a)
RAC2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rac2 35
  • 89.24 (n)
  • 98.96 (a)
Rac2 16
Rac2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rac2 35
  • 90.1 (n)
  • 98.96 (a)
oppossum
(Monodelphis domestica)
Mammalia RAC2 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAC2 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAC2 35
  • 83.51 (n)
  • 98.44 (a)
RAC2 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAC2 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rac2 35
  • 77.78 (n)
  • 92.71 (a)
Str.15383 35
zebrafish
(Danio rerio)
Actinopterygii rac2 35
  • 79.17 (n)
  • 93.75 (a)
rac2 36
  • 82 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mtl 37
  • 68 (a)
Rac1 37
  • 89 (a)
Rac2 37
  • 88 (a)
RhoL 37
  • 51 (a)
Mtl 36
  • 66 (a)
ManyToMany
Rac1 36
  • 89 (a)
ManyToMany
Rac2 36
  • 88 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ced-10 37
  • 95 (a)
F22E12.2 37
  • 44 (a)
mig-2 37
  • 62 (a)
Y32F6B.3 37
  • 44 (a)
rac-2 36
  • 72 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons RAC10 35
  • 58.38 (n)
  • 60.77 (a)
soybean
(Glycine max)
eudicotyledons Gma.1324 35
barley
(Hordeum vulgare)
Liliopsida Hv.12745 35
rice
(Oryza sativa)
Liliopsida Os.5505 35
Os06g0234200 35
  • 61.47 (n)
  • 62.9 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.7476 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2693 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02160 35
  • 70.37 (n)
  • 75.66 (a)
Species with no ortholog for RAC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RAC2 Gene

ENSEMBL:
Gene Tree for RAC2 (if available)
TreeFam:
Gene Tree for RAC2 (if available)

Paralogs for RAC2 Gene

Paralogs for RAC2 Gene

genes like me logo Genes that share paralogs with RAC2: view

Variants for RAC2 Gene

Sequence variations from dbSNP and Humsavar for RAC2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_017452 Neutrophil immunodeficiency syndrome (NEUID)
VAR_036569 A breast cancer sample
rs6572 -- 37,225,405(-) CTGCT(C/G)CACTC utr-variant-3-prime
rs2157206 -- 37,240,311(+) GCCCC(A/C)GCGAG intron-variant
rs2213430 -- 37,242,920(+) CATGC(C/T)CCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAC2 Gene

Variant ID Type Subtype PubMed ID
nsv829203 CNV Loss 20364138
nsv915020 CNV Loss 21882294
nsv834188 CNV Loss 17160897
nsv459883 CNV Loss 19166990
nsv513590 CNV Insertion 21212237
esv2724208 CNV Deletion 23290073
nsv528767 CNV Gain 19592680
esv1002006 CNV Loss 20482838

Variation tolerance for RAC2 Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAC2 Gene

HapMap Linkage Disequilibrium report
RAC2
Human Gene Mutation Database (HGMD)
RAC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAC2 Gene

Disorders for RAC2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RAC2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neutrophil immunodeficiency syndrome
  • neuid
chronic granulomatous disease
  • bridges-good syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RAC2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

RAC2_HUMAN
  • Neutrophil immunodeficiency syndrome (NEUID) [MIM:608203]: An immunodeficiency syndrome due to defective neutrophils. Affected individuals present with leukocytosis, neutrophilia, severe recurrent bacterial infections and poor wound healing. {ECO:0000269 PubMed:10758162}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RAC2

Genetic Association Database (GAD)
RAC2
Human Genome Epidemiology (HuGE) Navigator
RAC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAC2
genes like me logo Genes that share disorders with RAC2: view

No data available for Genatlas for RAC2 Gene

Publications for RAC2 Gene

  1. Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation. (PMID: 10758162) Ambruso D.R. … Roos D. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 23 48 67
  2. OAG induces an additional PKC-, PI3K-, and Rac2-mediated signaling pathway up-regulating NOX2 activity, independently of Ca2+ entry. (PMID: 19118104) BrAcchard S. … Tschirhart E.J. (J. Leukoc. Biol. 2009) 3 23
  3. Specific recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 guanine nucleotide exchange factors. (PMID: 18056264) Kwofie M.A. … Skowronski J. (J. Biol. Chem. 2008) 3 23
  4. Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function. (PMID: 17227822) Zhao T. … Bokoch G.M. (J. Leukoc. Biol. 2007) 3 23
  5. Characterization of IQGAP1-containing complexes in NK-like cells: evidence for Rac 2 and RACK1 association during homotypic adhesion. (PMID: 17269730) Meng X. … Wilkins J.A. (J. Proteome Res. 2007) 3 23

Products for RAC2 Gene

Sources for RAC2 Gene

Content