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RAC2 Gene

protein-coding   GIFtS: 73
GCID: GC22M037621

Ras-Related C3 Botulinum Toxin Substrate 2 (Rho Family,...

  See RAC2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ras-Related C3 Botulinum Toxin Substrate 2 (Rho Family, Small GTP
Binding Protein Rac2)1 2
     HSPC0222
Small G Protein2 3     Ras-Related C3 Botulinum Toxin Substrate 22
p21-Rac22 3     Ras-Related C3 Botulinum Toxin Substrate 3 (Rho Family, Small GTP-Binding
Protein Rac2)2
EN-72     GX3
Gx2     

External Ids:    HGNC: 98021   Entrez Gene: 58802   Ensembl: ENSG000001283407   OMIM: 6020495   UniProtKB: P151533   

Export aliases for RAC2 gene to outside databases

Previous GC identifers: GC22M034235 GC22M035864 GC22M035945 GC22M020586


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAC2 Gene:
This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The
encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion,
phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive
oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a
pseudogene for this gene on chromosome 6. (provided by RefSeq, Jul 2013)

GeneCards Summary for RAC2 Gene:
RAC2 (ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)) is a protein-coding gene. Diseases associated with RAC2 include neutrophil immunodeficiency syndrome. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOH.

UniProtKB/Swiss-Prot: RAC2_HUMAN, P15153
Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound
state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory
processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive
oxygen species (ROS) by NADPH oxidase

summary for RAC2 Gene:
Small G proteins (small GTPases) are homologous to Galpha proteins and are often referred to as the Ras
proto-oncogene superfamily. The Ras superfamily contains over 100 small GTPases grouped into eight families;
Ras, Rho, Rab, Rap, Arf, Ran, Rheb and Rad. Small GTPases regulate a wide variety of processes in the cell,
including growth, differentiation, movement and lipid vesicle transport. Like Galpha proteins, small GTPases
alternate between an 'on' state (bound to GTP) and an 'off' state (bound to GDP). This cyclic process
requires guanine nucleotide exchange factor (GEF) and GTPase-activating protein (GAP). Small GTPases are the
downstream effectors of most receptor tyrosine kinases (RTKs) and are linked via two proteins, GRB2 and SOS.
They are coupled to intracellular signaling cascades including the MAPK pathway, through interactions with
Raf kinase. Normally, activation of small GTPases is induced by ligand binding to a RTK. In many transformed
cells activating mutations of GTPases, often Ras, produce a cellular response in the absence of a ligand,
thus promoting malignant progression.

Gene Wiki entry for RAC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAC2 gene promoter:
         FAC1   AML1a   AP-1   ATF-2   Hand1   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAC2 promoter sequence
   Search Chromatin IP Primers for RAC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

RAC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAC2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M037621:  view genomic region     (about GC identifiers)

Start:
37,621,301 bp from pter      End:
37,640,488 bp from pter
Size:
19,188 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RAC2_HUMAN, P15153 (See protein sequence)
Recommended Name: Ras-related C3 botulinum toxin substrate 2 precursor  
Size: 192 amino acids; 21429 Da
Subunit: Interacts with DOCK2, which may activate it. Interacts with S100A8 and calprotectin (S100A8/9)
4 PDB 3D structures from and Proteopedia for RAC2:
1DS6 (3D)        2W2T (3D)        2W2V (3D)        2W2X (3D)    
Secondary accessions: Q9UDJ4

Explore the universe of human proteins at neXtProt for RAC2: NX_P15153

Explore proteomics data for RAC2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys123, Lys133, Lys147, Lys153, Lys166
  • Modification sites at PhosphoSitePlus

  • See RAC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002863.1  
    ENSEMBL proteins: 
     ENSP00000249071   ENSP00000385270   ENSP00000385590   ENSP00000403778   ENSP00000385666  
    Reactome Protein details: P15153

    RAC2 Human Recombinant Protein Products:

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    Novus Biologicals RAC2 Proteins
    Novus Biologicals RAC2 Lysate
    Sino Biological Recombinant Protein for RAC2
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for RAC2
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for RAC2 

     
    antibodies-online proteins for RAC2 (26 products) 

     
    antibodies-online peptides for RAC2

    RAC2 Antibody Products:

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    Abcam antibodies for RAC2 (P15153, P17081)
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    antibodies-online antibodies for RAC2 (47 products) 

    RAC2 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for RAC2 
    antibodies-online kits for RAC2 (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    4 InterPro protein domains:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P15153

    ProtoNet protein and cluster: P15153

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RAC2_HUMAN, P15153
    Similarity: Belongs to the small GTPase superfamily. Rho family


    Find genes that share domains with RAC2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAC2_HUMAN, P15153
    Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound
    state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory
    processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive
    oxygen species (ROS) by NADPH oxidase
    Enzyme regulation: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP
    for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation
    inhibitors which inhibit the dissociation of the nucleotide from the GTPase

         Genatlas biochemistry entry for RAC2:
    ras-related C3 botulinism toxin substrate 2,Ras-like protein,member of the Rho family of GTPase,specifically
    expressed in hemopoietic lineage,involved in the production of superoxide in neutrophils,putative regulator of
    mitogen-induced cytoskeletal changes essential for membrane ruffling,and C-jun aminoterminal kinase JNK,key
    downstream target in Ras signaling putatively mediated by EPS58 and SSH3BP1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with RAC2           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for RAC2:
     Altered focal adhesion (FA) or  Cell cycle / mitosis defect  Increased cell death HMECs cel  Upregulation of Wnt/beta-caten 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rac2):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging 

    Find genes that share phenotypes with RAC2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rac2tm1Mddw for RAC2

       genOway: Develop your customized and physiologically relevant rodent model for RAC2

    miRNA
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    miRTarBase miRNAs that target RAC2:
    hsa-mir-193b-3p (MIRT016574)

    Block miRNA regulation of human, mouse, rat RAC2 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate RAC2:
    hsa-miR-1184 hsa-miR-378* hsa-miR-1205
    SwitchGear 3'UTR luciferase reporter plasmidRAC2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat RAC2

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    GenScript: all cDNA clones in your preferred vector: RAC2 (NM_002872)
    Sino Biological Human cDNA Clone for RAC2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAC2
    Addgene plasmids for RAC2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RAC2_HUMAN, P15153: Cytoplasm. Note=Membrane-associated when activated
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane4
    cytoskeleton3
    extracellular2
    golgi apparatus2
    nucleus2
    endoplasmic reticulum1
    endosome1
    lysosome1
    mitochondrion1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005635nuclear envelope IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with RAC2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAC2 About   (see all 66)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    Focal Adhesion0.65
    2Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    3Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    4MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    5Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathways0.40


    Find genes that share SuperPaths with RAC2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for RAC2
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RAC2 (see all 51)
        Fc-GammaR Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    G12-G13 in Cellular Signaling
    TRKA Signaling

    2 Cell Signaling Technology (CST) Pathways for RAC2
        MAP Kinase Signaling
    Cytoskeletal Signaling

    4 GeneGo (Thomson Reuters) Pathways for RAC2
        G-protein signaling Rac2 regulation pathway
    Inhibitory action of Lipoxins on Superoxide production in neutrophils
    Inhibitory action of Lipoxins on neutrophil migration
    Immune response CCR3 signaling in eosinophils

    Selected BioSystems Pathways for RAC2 (see all 8)
        MAPK signaling pathway
    Focal Adhesion
    Integrin-mediated cell adhesion
    Insulin Signaling
    DNA damage response (only ATM dependent)

    1 Sino Biological Pathway for RAC2
        TGF-beta Signaling Pathway

    5 Reactome Pathways for RAC2
        Sema4D induced cell migration and growth-cone collapse
    G alpha (12/13) signalling events
    PCP/CE pathway
    Rho GTPase cycle
    GPVI-mediated activation cascade

    2 PharmGKB Pathways for RAC2
        Bisphosphonate Pathway, Pharmacodynamics
    Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for RAC2) (see all 19):
        MAPK signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    Chemokine signaling pathway
    Wnt signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RAC2: 
              Adherens Junctions in human mouse rat
              Leukemia in human mouse rat
              VEGF Signaling in human mouse rat
              Focal Adhesions in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RAC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAC2 (P151532, 3 ENSP000002490714) via UniProtKB, MINT, STRING, and/or I2D (see all 304)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGDIBP525662, 3, ENSP000002289454MINT-16596 MINT-24949 I2D: score=5 STRING: ENSP00000228945
    AFG3L2Q9Y4W62, 3, ENSP000002691434MINT-8267907 I2D: score=2 STRING: ENSP00000269143
    CHGBP050602, 3, ENSP000003682444MINT-8267918 I2D: score=2 STRING: ENSP00000368244
    ARHGDIAP525653, ENSP000002693214I2D: score=4 STRING: ENSP00000269321
    NOS2P352283, ENSP000003272514I2D: score=4 STRING: ENSP00000327251
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    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0006935chemotaxis ----
    GO:0007165signal transduction TAS2674130

    Find genes that share ontologies with RAC2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for RAC2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    QS 11ARFGAP1 inhibitor; modulates Wnt/beta-catenin signaling[944328-88-5]
    NSC 23766Selective inhibitor of Rac1-GEF interaction; antioncogenic[733767-34-5]
    EHT 1864Potent inhibitor of Rac family GTPases[754240-09-0]
    SecinH3Sec7-specific GEF inhibitor (cytohesins)[853625-60-2]
    Rac1 Inhibitor W56Selective inhibitor of Rac1-GEF interaction[1095179-01-3]

    4 HMDB Compounds for RAC2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

    Selected Novoseek inferred chemical compound relationships for RAC2 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nadph 80.9 43 12471136 (3), 15981461 (2), 14660749 (2), 8670049 (2) (see all 32)
    fmlp 64 13 12391220 (2), 10364257 (2), 8670049 (2), 17060455 (1) (see all 6)
    superoxide 61.9 21 15504745 (3), 1328203 (2), 12471136 (2), 19534724 (2) (see all 14)
    guanosine 58.5 3 10779444 (1), 16582540 (1), 15170212 (1)
    gtp 58.3 9 9748241 (2), 8305740 (2), 8089125 (1), 7479768 (1) (see all 5)
    n-formylmethionyl-leucylphenylalanine 43.4 2 10364257 (1)
    oxygen 36.3 6 9343750 (1), 16820949 (1), 10540223 (1), 8670049 (1) (see all 6)
    tyrosine 29.6 4 15944312 (2), 14550529 (1), 7616102 (1)
    phorbol 26.3 1 15504745 (1)
    asparagine 14.2 1 14676277 (1)

    1 PharmGKB related drug/compound annotation for RAC2 gene    About this table
    Drug/compound PharmGKB Annotation
    doxorubicinCA  



    Find genes that share compounds with RAC2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RAC2 gene: 
    NM_002872.4  

    Unigene Cluster for RAC2:

    Ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
    Hs.517601  [show with all ESTs]
    Unigene Representative Sequence: AK096924
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000249071(uc003arc.3) ENST00000406508 ENST00000481215 ENST00000405484
    ENST00000441619 ENST00000469532 ENST00000401529
    miRNA
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    hsa-miR-1184 hsa-miR-378* hsa-miR-1205
    SwitchGear 3'UTR luciferase reporter plasmidRAC2 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAC2
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      QuantiTect SYBR Green Assays in human, mouse, rat RAC2
      QuantiFast Probe-based Assays in human, mouse, rat RAC2

    Additional mRNA sequence: 

    AF077208.1 AF498965.1 AK096924.1 BC001485.2 BC018735.1 BC051899.1 BT006919.1 CR456555.1 
    M29871.1 

    12 DOTS entries:

    DT.416967  DT.100827641  DT.100716835  DT.99930448  DT.100827645  DT.91846232  DT.100827643  DT.100827650 
    DT.100827653  DT.416969  DT.92445198  DT.92445205 

    Selected AceView cDNA sequences (see all 341):

    CA454791 CR614981 AA310079 BG106565 BC018735 BM807151 BI908639 CR621380 
    BM849925 CR600269 BM458676 CD615939 BQ061687 BG685541 BX353261 BE616329 
    BQ049570 CA306995 BQ057744 BI261649 BG342022 AI640644 BG106220 AW768485 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RAC2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                                -           -                           
    SP2:                    -           -           -                           
    SP3:                                -                                       
    SP4:                                                                        


    ECgene alternative splicing isoforms for RAC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAAGCATC
    RAC2 Expression
    About this image


    RAC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Liver (Hepatobiliary System)
             Liver Bud
     
     Blood (Hematopoietic System)
             Plasmacytoid Dendritic cells Peripheral Blood
    RAC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517601

    UniProtKB/Swiss-Prot: RAC2_HUMAN, P15153
    Tissue specificity: Hematopoietic specific

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RAC2: 
              Adherens Junctions in human mouse rat
              Leukemia in human mouse rat
              VEGF Signaling in human mouse rat
              Focal Adhesions in human mouse rat
              Cell Motility in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAC2 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rac21 , 5 RAS-related C3 botulinum substrate 21, 5 89.24(n)1
    98.96(a)1
      15 (37.57 cM)5
    193541  NM_009008.31  NP_033034.11 
     785591695 
    chicken
    (Gallus gallus)
    Aves RAC21 ras-related C3 botulinum toxin substrate 2 (rho family, more 83.51(n)
    98.44(a)
      418044  NM_001201452.1  NP_001188381.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAC26
    ras-related C3 botulinum toxin substrate 2 (rho fa...
    96(a)
    1 ↔ 1
    5(22871006-22888857)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.153832 Transcribed sequence with strong similarity to protein more 79.72(n)    BX702895.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rac21 ras-related C3 botulinum toxin substrate 2 (rho family, more 79.17(n)
    93.75(a)
      415151  NM_001002061.1  NP_001002061.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rac13 cell proliferation GTPase 89(a)
    (best of 4)
      3 61F5   --
    worm
    (Caenorhabditis elegans)
    Secernentea ced-103 RAS-related protein 95(a)
    (best of 4)
      IV(3507381-3509495)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RAC101 RAC10 58.38(n)
    60.77(a)
      836408  NM_125682.4  NP_201093.1 
    rice
    (Oryza sativa)
    Liliopsida Os.55052 Oryza sativa mRNA for small GTP-binding protein OsRac3, more 73.03(n)    AB029510.1 


    ENSEMBL Gene Tree for RAC2 (if available)
    TreeFam Gene Tree for RAC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAC2 gene
    RHOH2  RHOQ2  RHOBTB12  RHOV2  RHOU2  RHOG2  RHOBTB22  RAC12  
    CDC422  RHOJ2  RAC32  
    Selected SIMAP similar genes for RAC2 using alignment to 5 protein entries:     RAC2_HUMAN (see all proteins) (see all similar genes):
    RAC3    RAC1    CDC42    RHOJ    ARHG    RHOG
    RHOQ    RHOV    RHOF    RHOU    RHOD    RHOH
    RHOC    RHOA    RHOB    RND2    ARHE    RND3

    Find genes that share paralogs with RAC2           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for RAC2 (see all 6)
    PGOHUM00000248381 PGOHUM00000258726 PGOHUM00000245512 PGOHUM00000245647 PGOHUM00000243694


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAC2 (see all 634)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365694
    A breast cancer sample4--see VAR_0365692 P L mis40--------
    VAR_0174524
    Neutrophil immunodeficiency syndrome (NEUID)4--see VAR_0174522 D N mis40--------
    rs743155071,2
    Cpathogenic137628897(-) TGTGGA/GACACT 2 N D mis10--------
    rs562111451,2
    C--20585826(-) GAAATA/GAAACA 1 -- ds50010--------
    rs60006191,2
    C,F,A,H--20585829(+) TTCATG/TTCACT 1 -- ds500110Minor allele frequency- T:0.23NA WA CSA EA 371
    rs559649141,2
    C--20585848(-) GGAAAG/TTGTTC 1 -- ds50012Minor allele frequency- T:0.04WA 120
    rs50051631,2
    C,F,A--20607407(+) gctcaT/Cgcctg 1 -- us2k15Minor allele frequency- C:0.22NA WA CSA 9
    rs130541431,2
    C--37620868(+) TTCCCG/ACCAGG 1 -- ds50013Minor allele frequency- A:0.07NA EA 242
    rs560345611,2
    C--37620905(-) ACTGGA/GGGGGA 1 -- ds50010--------
    rs59954001,2
    C,A,H--37620917(+) CACACA/GCTTTC 1 -- ds50018Minor allele frequency- G:0.23NA WA CSA EA 367

    HapMap Linkage Disequilibrium report for RAC2 (37621301 - 37640488 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for RAC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724208CNV Deletion23290073
    nsv513590CNV Insertion21212237
    nsv915020CNV Loss21882294
    nsv829203CNV Loss20364138
    esv1002006CNV Loss20482838
    nsv459883CNV Loss19166990
    nsv834188CNV Loss17160897
    nsv528767CNV Gain19592680

    Human Gene Mutation Database (HGMD): RAC2
    Locus Specific Mutation Databases (LSDB): RAC2

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAC2
    DNA2.0 Custom Variant and Variant Library Synthesis for RAC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602049   
    OMIM disorders: 608203  
    UniProtKB/Swiss-Prot: RAC2_HUMAN, P15153
  • Neutrophil immunodeficiency syndrome (NEUID) [MIM:608203]: An immunodeficiency syndrome due to defective
    neutrophils. Affected individuals present with leukocytosis, neutrophilia, severe recurrent bacterial infections
    and poor wound healing. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 1 disease for RAC2:    
    About MalaCards
    neutrophil immunodeficiency syndrome


    Find genes that share disorders with RAC2           About GenesLikeMe

    7 Novoseek inferred disease relationships for RAC2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    granulomatous disease chronic 43.5 1 8670049 (1)
    tumors 1 1 16491116 (1)
    bacterial infections 0 1 14676277 (1)
    inflammation 0 1 17975262 (1)
    gastric cancer 0 1 14975755 (1)
    metastasis 0 1 16491116 (1)
    immunodeficiency 0 4 10758162 (1), 11278678 (1), 10961859 (1), 12468931 (1)

    Genetic Association Database (GAD): RAC2
    Human Genome Epidemiology (HuGE) Navigator: RAC2 (14 documents)

    Export disorders for RAC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAC2 gene, integrated from 10 sources (see all 209):
    (articles sorted by number of sources associating them with RAC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation. (PubMed id 10758162)1, 2, 4, 9 Ambruso D.R.... Roos D. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    2. Rac, a novel ras-related family of proteins that are botulinum toxin substrates. (PubMed id 2674130)1, 2, 3 Didsbury J.... Snyderman R. (J. Biol. Chem. 1989)
    3. Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA. (PubMed id 1903399)1, 2, 9 Kinsella B.T.... Maltese W.A. (J. Biol. Chem. 1991)
    4. Regulation of the human neutrophil NADPH oxidase by rho-related G- proteins. (PubMed id 8504089)1, 2, 9 Kwong C.H.... Leto T.L. (Biochemistry 1993)
    5. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    6. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    7. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    8. Genetic polymorphisms in nitric oxide synthase genes modify the relationship between vegetable and fruit intake and risk of non-Hodgkin lymphoma. (PubMed id 19423521)1, 4 Han X....Zhang Y. (amp 2009)
    9. Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors. (PubMed id 19505917)1, 4 Bhatti P....Rajaraman P. (amp 2009)
    10. Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease. (PubMed id 18628988)1, 4 Li Y....Hadjigeorgiou G. (PLoS ONE 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5880 HGNC: 9802 AceView: RAC2 Ensembl:ENSG00000128340 euGenes: HUgn5880
    ECgene: RAC2 Kegg: 5880 H-InvDB: RAC2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RAC2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAC2 Genetics and Cytogenetics in Oncology and Haematology
    RAC2basehttp://bioinf.uta.fi/RAC2base/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAC2 gene:
    Search GeneIP for patents involving RAC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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