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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAC1 Gene

protein-coding   GIFtS: 72
GCID: GC07P006380

Ras-Related C3 Botulinum Toxin Substrate 1 (Rho Family,...

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ras-Related C3 Botulinum Toxin Substrate 1 (Rho Family, Small GTP
Binding Protein Rac1)1 2
     Rac-12
Cell Migration-Inducing Gene 5 Protein2 3     TC-252
Ras-Like Protein TC252 3     Ras-Related C3 Botulinum Toxin Substrate 12
p21-Rac12 3     TC253

External Ids:    HGNC: 98011   Entrez Gene: 58792   Ensembl: ENSG000001362387   OMIM: 6020485   UniProtKB: P630003   

Export aliases for RAC1 gene to outside databases

Previous GC identifers: GC07P006058 GC07P006159 GC07P006160 GC07P006187


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAC1 Gene:
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins.
Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell
growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Mar 2009)

GeneCards Summary for RAC1 Gene: 
RAC1 (ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)) is a protein-coding gene. Diseases associated with RAC1 include recurrent respiratory papillomatosis, and tuberous sclerosis complex, and among its related super-pathways are Development EGFR signaling via small GTPases and Development FGF-family signaling. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOH.

UniProtKB/Swiss-Prot: RAC1_HUMAN, P63000
Function: Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound
states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as
secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced
formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma
1, which is involved in stimulation of the NADPH oxidase activity in macrophages (By similarity). Essential for
the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase
activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in
osteoclasts. In glioma cells, promotes cell migration and invasion
Function: Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is
restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not
full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector
interaction

summary for RAC1 Gene:
Small G proteins (small GTPases) are homologous to Galpha proteins and are often referred to as the Ras
proto-oncogene superfamily. The Ras superfamily contains over 100 small GTPases grouped into eight families;
Ras, Rho, Rab, Rap, Arf, Ran, Rheb and Rad. Small GTPases regulate a wide variety of processes in the cell,
including growth, differentiation, movement and lipid vesicle transport. Like Galpha proteins, small GTPases
alternate between an 'on' state (bound to GTP) and an 'off' state (bound to GDP). This cyclic process
requires guanine nucleotide exchange factor (GEF) and GTPase-activating protein (GAP). Small GTPases are the
downstream effectors of most receptor tyrosine kinases (RTKs) and are linked via two proteins, GRB2 and SOS.
They are coupled to intracellular signaling cascades including the MAPK pathway, through interactions with
Raf kinase. Normally, activation of small GTPases is induced by ligand binding to a RTK. In many transformed
cells activating mutations of GTPases, often Ras, produce a cellular response in the absence of a ligand,
thus promoting malignant progression.

Gene Wiki entry for RAC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAC1 gene promoter:
         AP-1   SRF (504 AA)   STAT5A   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): RAC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RAC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22   Ensembl cytogenetic band:  7p22.1   HGNC cytogenetic band: 7p22

RAC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAC1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P006380:  view genomic region     (about GC identifiers)

Start:
6,414,126 bp from pter      End:
6,443,608 bp from pter
Size:
29,483 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 6,460,486-6,489,951     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RAC1_HUMAN, P63000 (See protein sequence)
Recommended Name: Ras-related C3 botulinum toxin substrate 1 precursor  
Size: 192 amino acids; 21450 Da
Subunit: Interacts with NISCH. Interacts with PIP5K1A. Interacts with the GTP-bound form of RAB7A. Interacts with
SRGAP2. Interacts with CYFIP1/SRA-1. Interacts with PLXNB3. Interacts with ARHGDIA; the interaction is induced by
SEMA5A and mediated through PLXNB3 (By similarity). Interacts (GTP-bound form preferentially) with PKN2 (via the
REM repeats); the interaction stimulates autophosphorylation and phosphorylation of PKN2. Interacts with the GEF
proteins PREX1, RASGRF2, FARP1, FARP2, DOCK1, DOCK2 and DOCK7, which promote the exchange between GDP and GTP,
and therefore activate it. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a
quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein
(PRKCI or PRKCZ), which plays a central role in epithelial cell polarization. Found in a trimeric complex
composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Interacts with RALBP1
via its effector domain. Interacts with PLXNB1. Probably found in a ternary complex composed of DSCAM, PAK1 and
RAC1. Interacts with DSCAM; the interaction requires PAK1. Part of a complex with MAP2K3, MAP3K3, CCM2 and DEF6.
Interacts with BAIAP2, BAIAP2L1 and DEF6. Interacts with Y.pseudotuberculosis YPKA and PLCB2. Interacts with
NOXA1. Interacts with ARHGEF2. Interacts with TBC1D2. Interacts with UNKL. Interacts with USP6. Interacts with
SPATA13. Interacts with ARHGEF16; mediates activation of RAC1 by EPHA2. Interacts with ITGB4. Interacts with
S100A8 and calprotectin (S100A8/9). Interacts with PACSIN2. Interacts with ITGB1BP1
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Melanosome. Cytoplasm (By
similarity). Note=Inner surface of plasma membrane possibly with attachment requiring prenylation of the
C-terminal cysteine (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to
stage IV. Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of
bone-resorbing osteoclasts (By similarity)
Sequence caution: Sequence=AAZ80485.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
6/31 PDB 3D structures from and Proteopedia for RAC1 (see all 31):
1E96 (3D)        1FOE (3D)        1G4U (3D)        1HE1 (3D)        1HH4 (3D)        1I4D (3D)    
Secondary accessions: O95501 P15154 Q3Y4D3 Q5JAA8 Q9BTB4
Alternative splicing: 2 isoforms:  P63000-1, P15154-1   P63000-2, P15154-2   (Contains a phosphoserine at position 71)

Explore the universe of human proteins at neXtProt for RAC1: NX_P63000

Explore proteomics data for RAC1 at MOPED 

Post-translational modifications:

  • UniProtKB: AMPylation at Tyr-32 and Thr-35 are mediated by bacterial enzymes in case of infection by H.somnus and
    V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the
    GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in
    infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but
    additional experiments remain to be done to confirm results in vivo
  • UniProtKB: GTP-bound active form is ubiquitinated by HACE1, leading to its degradation by the proteasome
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P63000

  • RAC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAC1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_008839.2  NP_061485.1  

    ENSEMBL proteins: 
     ENSP00000258737   ENSP00000348461  
    Reactome Protein details: P63000
    Human Recombinant Protein Products for RAC1: 
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    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for RAC1
    OriGene Protein Over-expression Lysate for RAC1
    OriGene MassSpec for RAC1 
    OriGene Custom Protein Services for RAC1
    GenScript Custom Purified and Recombinant Proteins Services for RAC1
    Novus Biologicals RAC1 Proteins
    Novus Biologicals RAC1 Lysates
    Sino Biological Recombinant Protein for RAC1
    Sino Biological Cell Lysate for RAC1 
    ProSpec Recombinant Protein for RAC1
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/15 cellular component terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0001891phagocytic cup IEA--
    GO:0005622intracellular ----
    GO:0005737cytoplasm ----
    GO:0005802trans-Golgi network IDA12915445

    RAC1 for ontologies           About GeneDecksing



    RAC1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RAC1
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    Abcam antibodies for RAC1
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for RAC1
    LSBio Antibodies in human, mouse, rat for RAC1 

    Assay Products for RAC1: 
    EMD Millipore Kits and Assays for the Analysis of RAC1
    OriGene Custom Assay Services for RAC1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RAC1
    Enzo Life Sciences assays for RAC1
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P63000

    ProtoNet protein and cluster: P63000

    UniProtKB/Swiss-Prot: RAC1_HUMAN, P63000
    Domain: The effector region mediates interaction with DEF6
    Similarity: Belongs to the small GTPase superfamily. Rho family


    RAC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAC1_HUMAN, P63000
    Function: Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound
    states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as
    secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced
    formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma
    1, which is involved in stimulation of the NADPH oxidase activity in macrophages (By similarity). Essential for
    the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase
    activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in
    osteoclasts. In glioma cells, promotes cell migration and invasion
    Function: Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is
    restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not
    full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector
    interaction
    Enzyme regulation: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP
    for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation
    inhibitors which inhibit the dissociation of the nucleotide from the GTPase. GTP hydrolysis is stimulated by
    ARHGAP30

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS9312003
    GO:0005515protein binding IPI10051605
    GO:0005525GTP binding IDA15467718
    GO:0017137Rab GTPase binding IEA--
    GO:0019899enzyme binding IPI16636067
         
    RAC1 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for RAC1:
     Decreased focal adhesion (FA)   Decreased telomerase activity  Decreased viability after Chla  Increased cell death HMECs cel 
     Synthetic lethal with Ras 

         15/16 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Rac1) (see all 16):
     cardiovascular system  cellular  craniofacial  embryogenesis  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  integument 
     limbs/digits/tail  mortality/aging  muscle  nervous system  pigmentation 

    RAC1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RAC1: Rac1tm1.1Djk Rac1tm2Tyb Rac1tm1Jms

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RAC1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RAC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAC1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAC1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target RAC1:
    rno-mir-194 (MIRT003540), hsa-mir-122 (MIRT000663), hsa-mir-194 (MIRT005890)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAC1
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate RAC1 (see all 26):
    hsa-miR-3128 hsa-miR-320a hsa-miR-142-3p hsa-miR-137 hsa-miR-429 hsa-miR-485-3p hsa-miR-1271 hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidRAC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RAC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAC1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RAC1
    Sirion Biotech Customized adenovirus for overexpression of RAC1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RAC1 (see all 18)
    OriGene ORF clones in mouse, rat for RAC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RAC1 (NM_006908)
    Sino Biological Human cDNA Clone for RAC1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAC1
    Sirion Biotech Customized lentivirus for stable overexpression of RAC1 
                         Customized lentivirus expression plasmids for stable overexpression of RAC1 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAC1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAC1 About   (see all 188)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development HGF signaling pathway
    Development HGF signaling pathway0.78
    Development EGFR signaling via PIP30.40
    Development Neurotrophin family signaling0.45
    Neurotrophin signaling pathway0.36
    Development EGFR signaling via small GTPases0.44
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)0.31
    Development PDGF signaling via MAPK cascades0.41
    Renal cell carcinoma0.30
    2Development FGF-family signaling
    Development FGF-family signaling0.63
    Development Flt3 signaling0.45
    Development FGFR signaling pathway0.50
    FGF Pathway0.38
    3Focal Adhesion
    Focal Adhesion0.64
    Integrin-mediated cell adhesion0.38
    Focal adhesion0.64
    HGF Pathway0.34
    4Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathway0.40
    5Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.45
    Immune response CD16 signaling in NK cells0.32
    Immune response BCR pathway0.45
    Immune response Role of DAP12 receptors in NK cells0.32
    Fc epsilon RI signaling pathway0.40
    Natural killer cell mediated cytotoxicity0.31
    VEGF signaling pathway0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/46 EMD Millipore Pathways for RAC1 (see all 46)
        Chemotaxis CXCR4 signaling pathway
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling FAK signaling
    Cytoskeleton remodeling Role of PDGFs in cell migration
    Immune response CCR3 signaling in eosinophils

    3 R&D Systems Pathways for RAC1
        Wnt Signaling Pathway
    VEGF - VEGF R2 Signaling Pathways
    TGF-beta Signaling Pathways

    5/76 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RAC1 (see all 76)
        Fc-GammaR Pathway
    Toll-Like Receptors Pathway
    Molecular Mechanisms of Cancer
    JNK Pathway
    Inhibition of Ribosome Biogenesis by p14(ARF)

    2 Cell Signaling Technology (CST) Pathways for RAC1
        MAP Kinase Signaling
    Cytoskeletal Signaling

    5/49 GeneGo (Thomson Reuters) Pathways for RAC1 (see all 49)
        G-protein signaling Regulation of RAC1 activity
    Cytoskeleton remodeling Role of PDGFs in cell migration
    Development FGF-family signaling
    Development EGFR signaling pathway
    Development Endothelin-1/EDNRA signaling

    5/74 BioSystems Pathways for RAC1 (see all 74)
        TOR signaling
    MAPK signaling pathway
    Focal Adhesion
    NOD pathway
    MicroRNAs in cardiomyocyte hypertrophy

    2 Sino Biological Pathways for RAC1 
        EGFR Signaling Pathway
    Non-Canonical Wnt Pathway

    5/47        Reactome Pathways for RAC1 (see all 47)
        L1CAM interactions
    CD28 dependent Vav1 pathway
    FCERI mediated MAPK activation
    Costimulation by the CD28 family
    G alpha (12/13) signalling events

    2 PharmGKB Pathways for RAC1
        Bisphosphonate Pathway, Pharmacodynamics
    Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics

    5/32         Kegg Pathways  (Kegg details for RAC1) (see all 32):
        MAPK signaling pathway
    Chemokine signaling pathway
    Phagosome
    PI3K-Akt signaling pathway
    Wnt signaling pathway


    RAC1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/456 Interacting proteins for RAC1 (P630001, 2, 3 ENSP000003484614) via UniProtKB, MINT, STRING, and/or I2D (see all 456)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAK1Q131531, 2, 3, ENSP000002785684EBI-413628,EBI-1307 MINT-49675 MINT-8078140 MINT-7145274 MINT-8320267 MINT-60985 MINT-7217644 MINT-7146277 MINT-4298496 MINT-7384952 MINT-7288809 I2D: score=12 STRING: ENSP00000278568
    SETQ011052, 3, ENSP000003617774MINT-4298550 MINT-4298508 MINT-4298480 MINT-4298402 MINT-8401879 MINT-4298417 MINT-4298434 MINT-4298526 I2D: score=3 STRING: ENSP00000361777
    DOCK1Q141851, 2, 3EBI-413628,EBI-446740 MINT-7306029 MINT-7305963 I2D: score=6 
    ARHGEF7Q141552, 3, ENSP000003648934MINT-7145257 MINT-7145327 MINT-7145306 MINT-7145341 MINT-7145361 MINT-7145246 MINT-7145235 I2D: score=3 STRING: ENSP00000364893
    PLCG1P191742, 3, ENSP000002440074MINT-7230055 MINT-7229927 MINT-7229937 MINT-7229970 MINT-7230002 MINT-7230027 MINT-7229952 I2D: score=1 STRING: ENSP00000244007
    About this table

    Gene Ontology (GO): 5/63 biological process terms (GO ID links to tree view) (see all 63):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002093auditory receptor cell morphogenesis IEA--
    GO:0002551mast cell chemotaxis IEA--
    GO:0003382epithelial cell morphogenesis IEA--
    GO:0006184GTP catabolic process ----
    GO:0006897endocytosis ----

    RAC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RAC1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for RAC1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    QS 11ARFGAP1 inhibitor; modulates Wnt/beta-catenin signaling[944328-88-5]
    NSC 23766Selective inhibitor of Rac1-GEF interaction; antioncogenic[733767-34-5]
    EHT 1864Potent inhibitor of Rac family GTPases[754240-09-0]
    SecinH3Sec7-specific GEF inhibitor (cytohesins)[853625-60-2]
    Rac1 Inhibitor W56Selective inhibitor of Rac1-GEF interaction[1095179-01-3]

    5 HMDB Compounds for RAC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Pravastatin3beta-Hydroxycompactin (see all 7)81093-37-0--
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    1 DrugBank Compound for RAC1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Diphosphate-- 146-91-8target----

    10/90 Novoseek inferred chemical compound relationships for RAC1 gene (see all 90)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 76.8 53 7980444 (5), 10893266 (3), 11900529 (2), 15242348 (2) (see all 27)
    nadph 76.1 128 11007780 (5), 9585526 (3), 19344766 (3), 18658277 (3) (see all 85)
    gtp 69.6 72 7980444 (3), 10893266 (3), 10036235 (2), 12620811 (2) (see all 40)
    phosphatidylinositol 67.3 48 9488489 (3), 19473989 (2), 10594018 (2), 15836616 (2) (see all 34)
    mdi-a 65.8 1 12445462 (1)
    diphenyleneiodonium 63.2 8 17008589 (1), 16990552 (1), 10747906 (1), 18218673 (1) (see all 5)
    geranylgeranyl pyrophosphate 62.4 6 16873994 (2), 17556673 (1), 15701825 (1), 17279352 (1)
    tyrosine 61.2 48 8816388 (2), 19366706 (2), 17093062 (2), 9430636 (1) (see all 38)
    phosphoinositide 59.6 23 17140407 (3), 11278419 (2), 19723872 (2), 11805146 (1) (see all 12)
    guanosine 59 14 19645540 (2), 17954607 (1), 10871853 (1), 15521546 (1) (see all 11)

    Search CenterWatch for drugs/clinical trials and news about RAC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAC1 gene (3 alternative transcripts): 
    NM_006908.4  NM_018890.3  NM_198829.1  

    Unigene Cluster for RAC1:

    Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
    Hs.413812  [show with all ESTs]
    Unigene Representative Sequence: AB209410
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000348035(uc003spw.3 uc003spx.3 uc021zzg.1) ENST00000356142
    ENST00000488373 ENST00000497741 ENST00000473564 ENST00000495499
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB209410.1 AB451238.1 AB451363.1 AF136373.1 AF498964.1 AJ012502.1 AJ132694.1 AK054993.1 
    AK291806.1 AK291815.1 AY279384.1 BC004247.1 BC050687.1 BC107748.1 BT007121.1 D25274.1 
    M29870.1 M31467.1 U85236.1 

    24/39 DOTS entries (see all 39):

    DT.100858626  DT.100690590  DT.97864716  DT.100045437  DT.95159201  DT.91931125  DT.92466364  DT.99943990 
    DT.121127892  DT.92044118  DT.92466365  DT.92005684  DT.100690587  DT.92028822  DT.95159178  DT.100045435 
    DT.100690586  DT.121127905  DT.100690597  DT.121127838  DT.121245026  DT.100690595  DT.121127894  DT.121127955 

    24/1283 AceView cDNA sequences (see all 1283):

    AK122742 CD722766 BQ062354 AI298058 BM765061 BQ924637 BX116639 N46168 
    CB151498 BM852565 BM671033 BQ427707 BQ721925 BU167073 BU527964 AA135310 
    AI313406 BQ426085 AF136373 F02612 AA523955 BX363754 H12919 BM460125 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAC1 expression in normal human tissues (normalized intensities)      RAC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGACTTAA
    RAC1 Expression
    About this image


    RAC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/25 selected tissues (see all 25) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 20 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             Septum   
     
     Somite (Muscoskeletal System)    fully expand to see all 16 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             rectum ; glandular cells   
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hindlimb Dorsal Muscle

    See RAC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAC1

    SOURCE GeneReport for Unigene cluster: Hs.413812

    UniProtKB/Swiss-Prot: RAC1_HUMAN, P63000
    Tissue specificity: Isoform B is predominantly identified in skin and epithelial tissues from the intestinal
    tract. Its expression is elevated in colorectal tumors at various stages of neoplastic progression, as compared
    to their respective adjacent tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including RAC1 (see all 15): 
              Neurogenesis in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat
              Wound Healing in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAC1 gene from 9/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rac11 , 5 RAS-related C3 botulinum substrate 11, 5 91.67(n)1
    100(a)1
      5 (82.22 cM)5
    193531  NM_009007.21  NP_033033.11 
     1435054785 
    chicken
    (Gallus gallus)
    Aves RAC11 ras-related C3 botulinum toxin substrate 1 (rho family, more 88.19(n)
    100(a)
      395871  NM_205017.1  NP_990348.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAC16
    Uncharacterized protein
    100(a)
    1 ↔ 1
    GL343507.1(107208-123345)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.265882 Xenopus laevis rac GTPase mRNA, complete cds 84.78(n)    AF174644.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc558232 similar to CEll Death abnormality CED-10, RAC related more 80.78(n)   393898  BC044501.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rac13
    Rac21
    cell proliferation GTPase3
    CG8556-PA1
    91(a)
    (best of 4)3
    72.22(n)1
    89.58(a)1
      3 61F53
    388311  NM_139864.21  NP_648121.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ced-101 , 3 RAS-related protein3
    Protein CED-101
    97(a)
    (best of 5)3
    68.59(n)1
    83.25(a)1
      IV(3507381-3509495)3
    1771111  NM_067962.41  NP_500363.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RAC31 Rac-like GTP-binding protein ARAC3 61.02(n)
    67.76(a)
      829654  NM_001203987.1  NP_001190916.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g08340001 hypothetical protein 61.14(n)
    66.85(a)
      4331272  NM_001055174.1  NP_001048639.1 


    ENSEMBL Gene Tree for RAC1 (if available)
    TreeFam Gene Tree for RAC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAC1 gene
    RHOH2  RHOQ2  RHOBTB12  RHOV2  RHOU2  RHOG2  RHOBTB22  RAC22  
    CDC422  RHOJ2  RAC32  
    18/37 SIMAP similar genes for RAC1 using alignment to 4 protein entries:     RAC1_HUMAN (see all proteins) (see all similar genes):
    RAC3    RAC2    CDC42    ARHG    RHOG    RHOJ
    RHOQ    RHOV    RHOD    RHOF    RHOU    RHOB
    RHOC    RHOH    RND2    RHOA    ARHE    ARHH

    RAC1 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for RAC1
    PGOHUM00000234900 PGOHUM00000244483 PGOHUM00000237589 PGOHUM00000232968 PGOHUM00000233232


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1044 SNPs in RAC1 are shown (see all 1044)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0145464
    ----see VAR_0145462 T I mis40--------
    VAR_0145414
    ----see VAR_0145412 F L mis40--------
    VAR_0145424
    ----see VAR_0145422 A T mis40--------
    VAR_0145454
    ----see VAR_0145452 V G mis40--------
    VAR_0145444
    ----see VAR_0145442 V I mis40--------
    VAR_0145434
    ----see VAR_0145432 D G mis40--------
    VAR_0145404
    ----see VAR_0145402 N D mis40--------
    rs715399261,2
    C--6285537(+) AACAC-/T/TT  
            
    TTTTT
    2 -- us2k11NA 2
    rs43973031,2
    C,F--6286136(+) CACTGC/AAACCT 2 -- us2k13Minor allele frequency- A:0.18WA NA 240
    rs1405966111,2
    C--6289482(+) GTCTC-/ACAAAC 2 -- int10--------

    HapMap Linkage Disequilibrium report for RAC1 (6414126 - 6443608 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RAC1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv436904CNV Insertion17901297
    esv1914954OTHER Inversion16254605
    nsv7392OTHER Inversion18451855


    Human Gene Mutation Database (HGMD): RAC1
    1 SABiosciences Cancer Mutation PCR Assay for RAC1:
    Cosmic IdAA Change
    125734p.P29S
    SeqTarget long-range PCR primers for resequencing RAC1
    DNA2.0 Custom Variant and Variant Library Synthesis for RAC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602048    OMIM disorders: --

    20/101 diseases for RAC1 (see all 101):    About MalaCards
    recurrent respiratory papillomatosis    tuberous sclerosis complex    clostridium difficile    tangier disease
    wiskott-aldrich syndrome    chronic granulomatous disease    hairy cell leukemia    blastoma
    myotonic dystrophy    familial adenomatous polyposis    bullous pemphigoid    shigellosis
    glioblastoma    tuberous sclerosis    testicular cancer    lissencephaly
    synovial sarcoma    fibrosarcoma    malignant glioma    pituitary adenoma

    2 diseases from the University of Copenhagen DISEASES database for RAC1:
    Cancer     Vascular disease

    RAC1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/57 Novoseek inferred disease relationships for RAC1 gene (see all 57)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 49.2 4 11493455 (1), 11179351 (1), 11865026 (1)
    metastasis 40.9 33 20426825 (4), 17049467 (3), 17631638 (1), 19276387 (1) (see all 22)
    tumors 38 88 10636882 (4), 20426825 (4), 11606575 (3), 10893266 (3) (see all 47)
    colorectal tumors 27.5 8 16551621 (1), 18165265 (1), 10597294 (1), 11768613 (1)
    cancer 25.2 14 20067638 (2), 15160999 (1), 14530271 (1), 15067337 (1) (see all 10)
    glioblastoma 24.3 9 18813807 (4), 14736526 (1), 16027728 (1), 11929835 (1)
    astrocytoma 18.5 7 14736526 (2), 16204049 (2), 15242348 (1), 17896341 (1) (see all 5)
    pancreatic tumor 16.5 1 12902401 (1)
    glomerulosclerosis 13.6 1 16690620 (1)
    melanoma 13.1 14 12482591 (2), 17952876 (2), 11571298 (1), 15059909 (1) (see all 9)

    Genetic Association Database (GAD): RAC1
    Human Genome Epidemiology (HuGE) Navigator: RAC1 (15 documents)

    Export disorders for RAC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAC1 gene, integrated from 9 sources (see all 1392):
    (articles sorted by number of sources associating them with RAC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors. (PubMed id 10597294)1, 2, 3, 9 Jordan P....Chastre E. (1999)
    2. Rac, a novel ras-related family of proteins that are botulinum toxin substrates. (PubMed id 2674130)1, 2, 3 Didsbury J.... Snyderman R. (1989)
    3. Armus is a Rac1 effector that inactivates Rab7 and re gulates E-cadherin degradation. (PubMed id 20116244)1, 2, 9 Frasa M.A....Braga V.M. (2010)
    4. Crystal structure of the Rac1-RhoGDI complex involved in NADPH oxidase activation. (PubMed id 11513578)1, 2, 9 Grizot S....Pebay-Peyroula E. (2001)
    5. The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling. (PubMed id 12612085)1, 2, 9 Masuda-Robens J.M....Chou M.M. (2003)
    6. Cooperation of DEF6 with activated Rac in regulating cell morphology. (PubMed id 17121847)1, 2, 9 Oka T.... Fukui Y. (2007)
    7. Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1. (PubMed id 11130063)1, 2, 9 Worthylake D.K.... Sondek J. (2000)
    8. Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA. (PubMed id 1903399)1, 2, 9 Kinsella B.T.... Maltese W.A. (1991)
    9. The F-BAR domain protein PACSIN2 associates with Rac1 and regulates cell spreading and migration. (PubMed id 21693584)1, 2 de Kreuk B.J....Hordijk P.L. (2011)
    10. The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1. (PubMed id 22036506)1, 2 Torrino S.... Lemichez E. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5879 HGNC: 9801 AceView: RAC1 Ensembl:ENSG00000136238 euGenes: HUgn5879
    ECgene: RAC1 Kegg: 5879 H-InvDB: RAC1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAC1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rac1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAC1 gene:
    Search GeneIP for patents involving RAC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for RAC1




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
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     Search LifeMap BioReagents cell lines for RAC1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAC1
     SwitchGear 3'UTR luciferase reporter plasmids for RAC1
     SwitchGear Promoter luciferase reporter plasmids for RAC1
     ThermoFisher Antibody for RAC1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAC1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RAC1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RAC1
    Customized:
     lentivirus for stable overexpression of RAC1
     lentivirus expression plasmids for stable overexpression of RAC1
     adenovirus for overexpression of RAC1
     LSBio Antibodies in human, mouse, rat for RAC1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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