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Aliases for RAC1 Gene

Aliases for RAC1 Gene

  • Ras-Related C3 Botulinum Toxin Substrate 1 (Rho Family, Small GTP Binding Protein Rac1) 2 3 5
  • Cell Migration-Inducing Gene 5 Protein 3 4
  • Ras-Like Protein TC25 3 4
  • P21-Rac1 3 4
  • Ras-Related C3 Botulinum Toxin Substrate 1 3
  • Rac-1 3
  • TC-25 3
  • MIG5 3
  • TC25 4

External Ids for RAC1 Gene

Previous GeneCards Identifiers for RAC1 Gene

  • GC07P006058
  • GC07P006159
  • GC07P006160
  • GC07P006187

Summaries for RAC1 Gene

Entrez Gene Summary for RAC1 Gene

  • The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for RAC1 Gene

RAC1 (Ras-Related C3 Botulinum Toxin Substrate 1 (Rho Family, Small GTP Binding Protein Rac1)) is a Protein Coding gene. Diseases associated with RAC1 include Chlamydia and Chronic Granulomatous Disease. Among its related pathways are Signaling by GPCR and Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling. GO annotations related to this gene include GTP binding and enzyme binding. An important paralog of this gene is RAC3.

UniProtKB/Swiss-Prot for RAC1 Gene

  • Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.

  • Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.

Tocris Summary for RAC1 Gene

  • Small G proteins (small GTPases) are homologous to Galpha proteins and are often referred to as the Ras proto-oncogene superfamily. Small GTPases regulate a wide variety of processes in the cell, including growth, differentiation, movement and lipid vesicle transport.

Gene Wiki entry for RAC1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAC1 Gene

Genomics for RAC1 Gene

Regulatory Elements for RAC1 Gene

Enhancers for RAC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F006398 0.9 Ensembl ENCODE 23.6 +24.9 24873 2.7 SAP130 ZNF133 MAFG CEBPG RARA ZNF121 ZNF316 SCRT2 ZNF600 ZBTB33 DAGLB RAC1 PIR50924 GC07M006427
GH07F006338 0.2 ENCODE 21.6 -35.4 -35371 1.4 PRDM10 RAC1 DAGLB EIF2AK1 ENSG00000207217 FAM220A GC07P006327
GH07F006403 0.6 ENCODE 18.8 +29.7 29663 1.6 HDGF CTCF JUN INSM2 SIN3A RAD21 FOSL1 POLR2A PRDM10 FOS DAGLB RAC1 KDELR2 PIR50924 GC07M006427
GH07F006423 1 Ensembl ENCODE 16.9 +49.8 49781 2.5 CTCF RAD21 ZIC2 ZNF121 ZFP69B ZFHX2 ZNF692 GLIS1 KLF9 PRDM10 DAGLB RAC1 ZDHHC4 GC07M006427 PIR50924
GH07F006433 1.2 FANTOM5 Ensembl ENCODE 11.6 +62.2 62224 6.2 ELF3 CTCF SAP130 ARID4B MAX RAD21 ZNF316 FOXK2 POLR2A PATZ1 DAGLB RAC1 ZNF815P ZDHHC4 GC07M006436 PIR51766 GC07M006445
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RAC1 on UCSC Golden Path with GeneCards custom track

Promoters for RAC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001557130 805 3401 HDGF PKNOX1 ARNT MLX ARID4B SIN3A ZNF2 YY1 ZNF207 KLF13

Genomic Location for RAC1 Gene

Chromosome:
7
Start:
6,374,495 bp from pter
End:
6,403,977 bp from pter
Size:
29,483 bases
Orientation:
Plus strand

Genomic View for RAC1 Gene

Genes around RAC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAC1 Gene

Proteins for RAC1 Gene

  • Protein details for RAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63000-RAC1_HUMAN
    Recommended name:
    Ras-related C3 botulinum toxin substrate 1
    Protein Accession:
    P63000
    Secondary Accessions:
    • O95501
    • P15154
    • Q3Y4D3
    • Q5JAA8
    • Q9BTB4

    Protein attributes for RAC1 Gene

    Size:
    192 amino acids
    Molecular mass:
    21450 Da
    Quaternary structure:
    • Interacts with NISCH. Interacts with PIP5K1A. Interacts with the GTP-bound form of RAB7A. Interacts with SRGAP2. Interacts with CYFIP1/SRA-1. Interacts with PLXNB3. Interacts with ARHGDIA; the interaction is induced by SEMA5A, mediated through PLXNB3 and inactivates and stabilizes RAC1. Interacts (GTP-bound form preferentially) with PKN2 (via the REM repeats); the interaction stimulates autophosphorylation and phosphorylation of PKN2. Interacts with the GEF proteins PREX1, RASGRF2, FARP1, FARP2, DOCK1, DOCK2 and DOCK7, which promote the exchange between GDP and GTP, and therefore activate it. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein (PRKCI or PRKCZ), which plays a central role in epithelial cell polarization. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Interacts with RALBP1 via its effector domain. Interacts with PLXNB1. Probably found in a ternary complex composed of DSCAM, PAK1 and RAC1. Interacts with DSCAM; the interaction requires PAK1. Part of a complex with MAP2K3, MAP3K3, CCM2 and DEF6. Interacts with BAIAP2, BAIAP2L1 and DEF6. Interacts with Y.pseudotuberculosis YPKA and PLCB2. Interacts with NOXA1. Interacts with ARHGEF2. Interacts with TBC1D2. Interacts with UNKL. Interacts with USP6. Interacts with SPATA13. Interacts with ARHGEF16; mediates activation of RAC1 by EPHA2. Interacts with ITGB4. Interacts with S100A8 and calprotectin (S100A8/9). Interacts with PACSIN2. Interacts with ITGB1BP1. Interacts (when active) with PPP5C (via TPR repeats); activates PPP5C phosphatase activity and translocates PPP5C to the cell membrane. Interacts with RAPH1 (via Ras associating and PH domains) (PubMed:18499456). Interacts with MTSS1L (via IMD domain); this interaction may be important to potentiate PDGF-induced RAC1 activation (PubMed:20875796).
    SequenceCaution:
    • Sequence=AAZ80485.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAC1 Gene

    Alternative splice isoforms for RAC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAC1 Gene

Post-translational modifications for RAC1 Gene

  • (Microbial infection) AMPylation at Tyr-32 and Thr-35 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo.
  • (Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rac and leads to actin disassembly.
  • GTP-bound active form is ubiquitinated by HACE1, leading to its degradation by the proteasome.
  • Ubiquitination at Lys 116, Lys 133, Lys 147, and Lys 153
  • Modification sites at PhosphoSitePlus

Other Protein References for RAC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RAC1 (RAC1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for RAC1

No data available for DME Specific Peptides for RAC1 Gene

Domains & Families for RAC1 Gene

Gene Families for RAC1 Gene

Protein Domains for RAC1 Gene

Graphical View of Domain Structure for InterPro Entry

P63000

UniProtKB/Swiss-Prot:

RAC1_HUMAN :
  • The effector region mediates interaction with DEF6.
  • Belongs to the small GTPase superfamily. Rho family.
Domain:
  • The effector region mediates interaction with DEF6.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RAC1: view

Function for RAC1 Gene

Molecular function for RAC1 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. GTP hydrolysis is stimulated by ARHGAP30.
UniProtKB/Swiss-Prot Function:
Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.
UniProtKB/Swiss-Prot Function:
Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.

Gene Ontology (GO) - Molecular Function for RAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity TAS 9312003
GO:0005515 protein binding IPI 7673236
GO:0005525 GTP binding IMP 19625648
GO:0017137 Rab GTPase binding IEA --
genes like me logo Genes that share ontologies with RAC1: view

Phenotypes for RAC1 Gene

MGI mutant phenotypes for RAC1:
inferred from 7 alleles
GenomeRNAi human phenotypes for RAC1:
genes like me logo Genes that share phenotypes with RAC1: view

Animal Models for RAC1 Gene

MGI Knock Outs for RAC1:

Animal Model Products

miRNA for RAC1 Gene

miRTarBase miRNAs that target RAC1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAC1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAC1 Gene

Localization for RAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAC1 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Cytoplasm. Note=Inner surface of plasma membrane possibly with attachment requiring prenylation of the C-terminal cysteine (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAC1 Gene COMPARTMENTS Subcellular localization image for RAC1 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
endosome 5
extracellular 5
golgi apparatus 5
nucleus 5
plasma membrane 5
cytoskeleton 4
mitochondrion 2
vacuole 2
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0000242 pericentriolar material IEA --
GO:0001891 phagocytic cup IEA --
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with RAC1: view

Pathways & Interactions for RAC1 Gene

genes like me logo Genes that share pathways with RAC1: view

Pathways by source for RAC1 Gene

SIGNOR curated interactions for RAC1 Gene

Gene Ontology (GO) - Biological Process for RAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IMP 23633677
GO:0002093 auditory receptor cell morphogenesis IEA --
GO:0002551 mast cell chemotaxis IEA --
GO:0003382 epithelial cell morphogenesis IEA --
GO:0006897 endocytosis IEA --
genes like me logo Genes that share ontologies with RAC1: view

Drugs & Compounds for RAC1 Gene

(62) Drugs for RAC1 Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pravastatin Approved Pharma Competitive, Inhibitor 149
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 510
Dextromethorphan Approved Pharma Target, inhibitor 129
Guanosine diphosphate Experimental Pharma Target 0
Guanosine monophosphate Experimental Pharma 0

(42) Additional Compounds for RAC1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CASIN
425399-05-9
SecinH3
853625-60-2

(5) Tocris Compounds for RAC1 Gene

Compound Action Cas Number
CASIN Cdc42 GTPase inhibitor 425399-05-9
EHT 1864 Potent inhibitor of Rac family GTPases 754240-09-0
NSC 23766 Selective inhibitor of Rac1-GEF interaction; antioncogenic 1177865-17-6
SecinH3 Sec7-specific GEF inhibitor (cytohesins) 853625-60-2
ZCL 278 Cdc42 inhibitor 587841-73-4

(7) ApexBio Compounds for RAC1 Gene

Compound Action Cas Number
Dynamin inhibitory peptide Peptide inhibitor of GTPase dynamin 251634-21-6
Dynole 34-2 1128165-88-7
EHop-016 Rac1/Rac3 GTPase inhibitor,potent and specific 1380432-32-5
EHT 1864 Rac family small GTPases inhibitor 754240-09-0
MitMAB 1119-97-7
NSC 23766 Selective inhibitor of Rac1-GEF interaction. 1177865-17-6
OctMAB 1120-02-1
genes like me logo Genes that share compounds with RAC1: view

Drug Products

Transcripts for RAC1 Gene

Unigene Clusters for RAC1 Gene

Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAC1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAC1 Gene

No ASD Table

Relevant External Links for RAC1 Gene

GeneLoc Exon Structure for
RAC1
ECgene alternative splicing isoforms for
RAC1

Expression for RAC1 Gene

mRNA expression in normal human tissues for RAC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAC1 Gene



Protein tissue co-expression partners for RAC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAC1 Gene:

RAC1

SOURCE GeneReport for Unigene cluster for RAC1 Gene:

Hs.413812

mRNA Expression by UniProt/SwissProt for RAC1 Gene:

P63000-RAC1_HUMAN
Tissue specificity: Isoform B is predominantly identified in skin and epithelial tissues from the intestinal tract. Its expression is elevated in colorectal tumors at various stages of neoplastic progression, as compared to their respective adjacent tissues.
genes like me logo Genes that share expression patterns with RAC1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for RAC1 Gene

Orthologs for RAC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAC1 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia RAC1 35
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAC1 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAC1 34 35
  • 99.48 (n)
-- 35
  • 90 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RAC1 34 35
  • 93.58 (n)
mouse
(Mus musculus)
Mammalia Rac1 34 16 35
  • 91.67 (n)
rat
(Rattus norvegicus)
Mammalia Rac1 34
  • 90.97 (n)
cow
(Bos Taurus)
Mammalia RAC1 34 35
  • 90.1 (n)
chicken
(Gallus gallus)
Aves CRAC1A 35
  • 100 (a)
OneToOne
RAC1 34
  • 88.19 (n)
lizard
(Anolis carolinensis)
Reptilia RAC1 35
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rac1 34
  • 85.24 (n)
Str.6635 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.26588 34
zebrafish
(Danio rerio)
Actinopterygii rac1b 35 35
  • 98 (a)
OneToMany
RAC1 (6 of 8) 35
  • 88 (a)
OneToMany
rac1a 34 35
  • 80.21 (n)
RAC1 (1 of 8) 35
  • 71 (a)
OneToMany
rac1l 35
  • 71 (a)
OneToMany
RAC1 (8 of 8) 35
  • 65 (a)
OneToMany
RAC1 (7 of 8) 35
  • 52 (a)
OneToMany
zgc55823 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8916 34
fruit fly
(Drosophila melanogaster)
Insecta Rac2 36 35
  • 89 (a)
Rac1 36 34 35
  • 73.78 (n)
Mtl 36
  • 71 (a)
RhoL 36
  • 53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005445 34
  • 73.44 (n)
worm
(Caenorhabditis elegans)
Secernentea ced-10 36
  • 97 (a)
rac-2 35
  • 75 (a)
ManyToMany
cdc-42 36
  • 69 (a)
mig-2 36
  • 67 (a)
F22E12.2 36
  • 48 (a)
Y32F6B.3 36
  • 45 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ARAC1 34
  • 60.14 (n)
rice
(Oryza sativa)
Liliopsida Os02g0120800 34
  • 58.79 (n)
Species where no ortholog for RAC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAC1 Gene

ENSEMBL:
Gene Tree for RAC1 (if available)
TreeFam:
Gene Tree for RAC1 (if available)

Paralogs for RAC1 Gene

Variants for RAC1 Gene

Sequence variations from dbSNP and Humsavar for RAC1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10224776 -- 6,394,710(+) agttt(C/T)gctct intron-variant
rs10232409 -- 6,374,161(+) tgttg(C/G)ccagg upstream-variant-2KB
rs10234438 -- 6,383,169(+) CCAGC(A/G)GTATC intron-variant
rs10238136 -- 6,383,715(+) AGTCA(A/T)AACCT intron-variant
rs10270289 -- 6,381,455(+) TGGCA(C/T)GAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAC1 Gene

Variant ID Type Subtype PubMed ID
esv1914954 OTHER inversion 16254605
nsv1020236 CNV gain 25217958
nsv1114914 CNV deletion 24896259
nsv436904 CNV insertion 17901297
nsv605999 CNV loss 21841781
nsv7392 OTHER inversion 18451855
nsv956982 CNV deletion 24416366

Variation tolerance for RAC1 Gene

Residual Variation Intolerance Score: 39.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAC1 Gene

Human Gene Mutation Database (HGMD)
RAC1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAC1 Gene

Disorders for RAC1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RAC1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chlamydia
  • chlamydia trachomatis infectious disease
chronic granulomatous disease
  • bridges-good syndrome
pancreatic cancer
  • pancreatic carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards
Search RAC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RAC1

Genetic Association Database (GAD)
RAC1
Human Genome Epidemiology (HuGE) Navigator
RAC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAC1
genes like me logo Genes that share disorders with RAC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAC1 Gene

Publications for RAC1 Gene

  1. Armus is a Rac1 effector that inactivates Rab7 and regulates E- cadherin degradation. (PMID: 20116244) Frasa M.A. … Braga V.M. (Curr. Biol. 2010) 3 4 22 64
  2. Cooperation of DEF6 with activated Rac in regulating cell morphology. (PMID: 17121847) Oka T. … Fukui Y. (J. Biol. Chem. 2007) 3 4 22 64
  3. Crystal structure of the Rac1-RhoGDI complex involved in NADPH oxidase activation. (PMID: 11513578) Grizot S. … Pebay-Peyroula E. (Biochemistry 2001) 3 4 22 64
  4. Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1. (PMID: 11130063) Worthylake D.K. … Sondek J. (Nature 2000) 3 4 22 64
  5. Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors. (PMID: 10597294) Jordan P. … Chastre E. (Oncogene 1999) 2 3 4 64

Products for RAC1 Gene

Sources for RAC1 Gene

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