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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAC1 Gene

protein-coding   GIFtS: 71
GCID: GC07P006380

ras-related C3 botulinum toxin substrate 1 (rho family,...
 Explore 96 diseases affiliated with
RAC1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RAC1    

Aliases
for RAC1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ras-Related C3 Botulinum Toxin Substrate 1 (Rho Family, Small GTP Binding
Protein Rac1)1 2
     Cell Migration-Inducing Gene 5 Protein2 3
P21-Rac11     Ras-Like Protein TC252 3
Rac-11 2     Ras-Related C3 Botulinum Toxin Substrate 12
TC-251 2     TC253

External Ids:    HGNC: 98011   Entrez Gene: 58792   Ensembl: ENSG000001362387   OMIM: 6020485   UniProtKB: P630003   

Export aliases for RAC1 gene to outside databases

Previous GC identifers: GC07P006058 GC07P006159 GC07P006160 GC07P006187


Summaries
for RAC1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RAC1:
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins.
Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell
growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Mar 2009)

UniProtKB/Swiss-Prot: RAC1_HUMAN, P63000
Function: Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states.
In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory
processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of
membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is
involved in stimulation of the NADPH oxidase activity in macrophages (By similarity). Essential for the
SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity.
In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma
cells, promotes cell migration and invasion
Function: Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is
restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not
full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector
interaction

summary for RAC1:
Small G proteins (small GTPases) are homologous to Galpha proteins and are often referred to as the Ras
proto-oncogene superfamily. The Ras superfamily contains over 100 small GTPases grouped into eight families;
Ras, Rho, Rab, Rap, Arf, Ran, Rheb and Rad. Small GTPases regulate a wide variety of processes in the cell,
including growth, differentiation, movement and lipid vesicle transport. Like Galpha proteins, small GTPases
alternate between an 'on' state (bound to GTP) and an 'off' state (bound to GDP). This cyclic process
requires guanine nucleotide exchange factor (GEF) and GTPase-activating protein (GAP). Small GTPases are the
downstream effectors of most receptor tyrosine kinases (RTKs) and are linked via two proteins, GRB2 and SOS.
They are coupled to intracellular signaling cascades including the MAPK pathway, through interactions with
Raf kinase. Normally, activation of small GTPases is induced by ligand binding to a RTK. In many transformed
cells activating mutations of GTPases, often Ras, produce a cellular response in the absence of a ligand,
thus promoting malignant progression.

Gene Wiki entry for RAC1


Genomic Views
for RAC1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAC1 gene promoter:
         AP-1   SRF (504 AA)   STAT5A   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): RAC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RAC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22   Ensembl cytogenetic band:  7p22.1   HGNC cytogenetic band: 7p22

RAC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAC1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P006380:  view genomic region     (about GC identifiers)

Start:
 6,414,126 bp from pter      End:
 6,443,608 bp from pter
Size:
 29,483 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 6,460,486-6,489,951     

Proteins
for RAC1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RAC1_HUMAN, P63000 (See protein sequence)
Recommended Name: Ras-related C3 botulinum toxin substrate 1 precursor  
Size: 192 amino acids; 21450 Da
Subunit: Interacts with NISCH. Interacts with PIP5K1A. Interacts with the GTP-bound form of RAB7A. Interacts with
SRGAP2. Interacts with CYFIP1/SRA-1. Interacts with PLXNB3. Interacts with ARHGDIA; the interaction is induced by
SEMA5A and mediated through PLXNB3 (By similarity). Interacts (GTP-bound form preferentially) with PKN2 (via the REM
repeats); the interaction stimulates autophosphorylation and phosphorylation of PKN2. Interacts with the GEF proteins
PREX1, RASGRF2, DOCK1, DOCK2 and DOCK7, which promote the exchange between GDP and GTP, and therefore activate it.
Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a quaternary complex containing PARD3,
some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein (PRKCI or PRKCZ), which plays a central
role in epithelial cell polarization. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central
role in phagocytosis of apoptotic cells. Interacts with RALBP1 via its effector domain. Interacts with PLXNB1.
Probably found in a ternary complex composed of DSCAM, PAK1 and RAC1. Interacts with DSCAM; the interaction requires
PAK1. Part of a complex with MAP2K3, MAP3K3, CCM2 and DEF6. Interacts with BAIAP2, BAIAP2L1 and DEF6. Interacts with
Y.pseudotuberculosis YPKA and PLCB2. Interacts with NOXA1. Interacts with ARHGEF2. Interacts with TBC1D2. Interacts
with UNKL. Interacts with USP6. Interacts with SPATA13. Interacts with ARHGEF16; mediates activation of RAC1 by EPHA2.
Interacts with ITGB4. Interacts with S100A8 and calprotectin (S100A8/9)
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Melanosome. Cytoplasm (By
similarity). Note=Inner surface of plasma membrane possibly with attachment requiring prenylation of the C-terminal
cysteine (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Found in
the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts (By
similarity)
Sequence caution: Sequence=AAZ80485.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
6/31 PDB 3D structures from and Proteopedia for RAC1 (see all 31):
1E96 (3D)        1FOE (3D)        1G4U (3D)        1HE1 (3D)        1HH4 (3D)        1I4D (3D)    
Secondary accessions: O95501 P15154 Q3Y4D3 Q5JAA8 Q9BTB4
Alternative splicing: 2 isoforms:  P63000-1, P15154-1   P63000-2, P15154-2   (Contains a phosphoserine at position 71)

Explore the universe of human proteins at neXtProt for RAC1: NX_P63000

Post-translational modifications:

  • AMPylation at Tyr-32 and Thr-35 are mediated by bacterial enzymes in case of infection by H.somnus and
    • V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase
    activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells.
    It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments
    remain to be done to confirm results in vivo1
  • GTP-bound active form is ubiquitinated by HACE1, leading to its degradation by the proteasome1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P63000

    • RAC1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_008839.2  NP_061485.1  

    ENSEMBL proteins: 
     ENSP00000258737   ENSP00000348461  
    Reactome Protein details: P63000
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): RAC1
    OriGene Protein Over-expression Lysate (see all 4): RAC1
    OriGene Custom Protein Services for RAC1 
    GenScript Custom Purified and Recombinant Proteins Services for RAC1
    Novus Biologicals RAC1 Proteins
    Novus Biologicals RAC1 Lysates
    Sino Biological Recombinant Protein for RAC1
    ProSpec Recombinant Protein for RAC1
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0001891phagocytic cup IEA--
    GO:0005624membrane fraction ----
    GO:0005737cytoplasm ----
    GO:0005802trans-Golgi network IDA12915445


    RAC1 for ontologies           About GeneDecksing



    RAC1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RAC1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for RAC1 
    OriGene Antibodies (see all 2): RAC1
    OriGene Custom Antibody Services for RAC1 
    GenScript Custom Superior Antibodies Services for RAC1
    Novus Biologicals RAC1 Antibodies
    Abcam antibodies for RAC1 
    Browse Antibodies at Uscn
    ThermoFisher Antibody for RAC1

    Assay Products for RAC1: 
    EMD Millipore Kits and Assays for the Analysis of RAC1
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RAC1
    Enzo Life Sciences assays for RAC1
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for RAC1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RAC1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase

    Graphical View of Domain Structure for InterPro Entry P63000

    ProtoNet protein and cluster: P63000

    UniProtKB/Swiss-Prot: RAC1_HUMAN, P63000
    Domain: The effector region mediates interaction with DEF6
    Similarity: Belongs to the small GTPase superfamily. Rho family


    Function
    for RAC1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RAC1_HUMAN, P63000
    Function: Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states.
    In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory
    processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of
    membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is
    involved in stimulation of the NADPH oxidase activity in macrophages (By similarity). Essential for the
    SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity.
    In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma
    cells, promotes cell migration and invasion
    Function: Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is
    restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not
    full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector
    interaction
    Enzyme regulation: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for
    free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation
    inhibitors which inhibit the dissociation of the nucleotide from the GTPase. GTP hydrolysis is stimulated by ARHGAP30

    miRNA
    Products:            		miRTarBase miRNAs that target RAC1:
    rno-mir-194 (MIRT003540), hsa-mir-122 (MIRT000663), hsa-mir-194 (MIRT005890)

    OriGene 3'-UTR Clone (see all 2): RAC1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAC1
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate RAC1 (see all 26):
    hsa-miR-3128 hsa-miR-320a hsa-miR-142-3p hsa-miR-137 hsa-miR-429 hsa-miR-485-3p hsa-miR-1271 hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmid: RAC1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAC1 (see all 7)
    OriGene siRNA: RAC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAC1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RAC1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAC1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAC1 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): RAC1 (NM_006908)
    Sino Biological Human cDNA Clone for RAC1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAC1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for RAC1
    Search LifeMap BioReagents cell lines for RAC1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAC1

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS9312003
    GO:0005515protein binding IPI10051605
    GO:0005525GTP binding IDA15467718
    GO:0017137Rab GTPase binding IEA--
    GO:0019899enzyme binding IPI16636067


    RAC1 for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for RAC1:
     Decreased focal adhesion (FA)   Decreased telomerase activity  Decreased viability after Chla  Increased cell death HMECs cel 
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for RAC1: Rac1tm1.1Djk Rac1tm2Tyb Rac1tm1Jms
         15/16 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Rac1) (see all 16):
     cardiovascular system  cellular  craniofacial  embryogenesis  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  integument 
     limbs/digits/tail  mortality/aging  muscle  nervous system  pigmentation 

    RAC1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RAC1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/176 super-pathways (see all 176) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development HGF signaling pathway
    8/14 pathways (see all 14)
    		Development HGF signaling pathway1.00
    		Development PDGF signaling via MAPK cascades0.41
    		Development_HGF signaling pathway0.78
    		Development EGFR signaling via PIP30.26
    		Development_Neurotrophin family signaling0.45
    		Development_EGFR signaling via PIP30.26
    		Development Neurotrophin family signaling0.45
    		Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)0.23
    2Cell adhesion_Integrin-mediated cell adhesion and migration
    		Cell adhesion_Integrin-mediated cell adhesion and migration1.00
    		Cytoskeleton remodeling_Integrin outside-in signaling0.37
    		Cell adhesion Integrin-mediated cell adhesion and migration1.00
    		Cytoskeleton remodeling Integrin outside-in signaling0.37
    		Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases0.49
    		Cytoskeleton remodeling Fibronectin-binding integrins in cell motility0.32
    		Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    		Cytoskeleton remodeling_Fibronectin-binding integrins in cell motility0.32
    3G-protein signaling_Ras family GTPases in kinase cascades (scheme)
    		G-protein signaling Ras family GTPases in kinase cascades (scheme)1.00
    		Immune response Oncostatin M signaling via MAPK in human cells0.39
    		G-protein signaling_Ras family GTPases in kinase cascades (scheme)1.00
    		Immune response_Role of integrins in NK cells cytotoxicity0.28
    		Immune response_Oncostatin M signaling via MAPK in human cells0.39
    		Immune response Role of integrins in NK cells cytotoxicity0.28
    4PKC-Theta Pathway
    		PKC-Theta Pathway1.00
    		Fc-EpsilonRI Pathway0.42
    		TCR Signaling0.68
    		PDGF Pathway0.35
    		ITK and TCR Signaling0.54
    5Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/46 EMD Millipore Pathways for RAC1 (see all 46)
        Chemotaxis CXCR4 signaling pathway
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling FAK signaling
    Cytoskeleton remodeling Role of PDGFs in cell migration
    Immune response CCR3 signaling in eosinophils

    2 R&D Systems Pathways for RAC1
        Wnt Signaling Pathway
    TGF-beta Signaling Pathways

    5/76 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RAC1 (see all 76)
        Fc-GammaR Pathway
    Toll-Like Receptors Pathway
    Molecular Mechanisms of Cancer
    JNK Pathway
    Inhibition of Ribosome Biogenesis by p14(ARF)

    2 Cell Signaling Technology (CST) Pathways for RAC1
        MAP Kinase Signaling
    Cytoskeletal Signaling

    5/49 GeneGo (Thomson Reuters) Pathways for RAC1 (see all 49)
        G-protein signaling Regulation of RAC1 activity
    Cytoskeleton remodeling Role of PDGFs in cell migration
    Development FGF-family signaling
    Development EGFR signaling pathway
    Development Endothelin-1/EDNRA signaling

    5/72 BioSystems Pathways for RAC1 (see all 72) 
        Wnt Signaling Pathway
    MicroRNAs in cardiomyocyte hypertrophy
    RalA downstream regulated genes
    EGFR1 Signaling Pathway
    G13 Signaling Pathway

    5/48        Reactome Pathways for RAC1 (see all 48)
        L1CAM interactions
    CD28 dependent Vav1 pathway
    Costimulation by the CD28 family
    G alpha (12/13) signalling events
    Signal transduction by L1

    2 PharmGKB Pathways for RAC1
        Bisphosphonate Pathway, Pharmacodynamics
    Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics

    5/27         Kegg Pathways  (Kegg details for RAC1) (see all 27):
        MAPK signaling pathway
    Chemokine signaling pathway
    Phagosome
    Wnt signaling pathway
    Axon guidance


    RAC1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/441 Interacting proteins for RAC1 (P630001, 2, 3 ENSP000003484614) via UniProtKB, MINT, STRING, and/or I2D (see all 441)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAK1Q131531, 2, 3, ENSP000002785684EBI-413628,EBI-1307 MINT-49675 MINT-8078140 MINT-7145274 MINT-8320267 MINT-60985 MINT-7217644 MINT-7146277 MINT-4298496 MINT-7384952 MINT-7288809 I2D: score=12 STRING: ENSP00000278568
    SETQ011052, 3, ENSP000003617774MINT-4298550 MINT-4298508 MINT-4298480 MINT-4298402 MINT-8401879 MINT-4298417 MINT-4298434 MINT-4298526 I2D: score=3 STRING: ENSP00000361777
    DOCK1Q141851, 2, 3EBI-413628,EBI-446740 MINT-7306029 MINT-7305963 I2D: score=6 
    ARHGEF7Q141552, 3, ENSP000003648934MINT-7145257 MINT-7145327 MINT-7145306 MINT-7145341 MINT-7145361 MINT-7145246 MINT-7145235 I2D: score=3 STRING: ENSP00000364893
    PLCG1P191742, 3, ENSP000002440074MINT-7230055 MINT-7229927 MINT-7229937 MINT-7229970 MINT-7230002 MINT-7230027 MINT-7229952 I2D: score=1 STRING: ENSP00000244007
    About this table

    Gene Ontology (GO): 5/56 biological process terms (GO ID links to tree view) (see all 56):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002093auditory receptor cell morphogenesis IEA--
    GO:0002551mast cell chemotaxis IEA--
    GO:0003382epithelial cell morphogenesis IEA--
    GO:0006184GTP catabolic process ----
    GO:0006897endocytosis ----


    RAC1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RAC1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RAC1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for RAC1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    NSC 23766Selective inhibitor of Rac1-GEF interaction; antioncogenic[733767-34-5]
    EHT 1864Potent inhibitor of Rac family GTPases[754240-09-0]
    PKC (19-36)Pseudosubstrate peptide; inhibitor of PKC[113731-96-7]

    5 HMDB Compounds for RAC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Pravastatin3beta-Hydroxycompactin (see all 7)81093-37-0--
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    1 DrugBank Compound for RAC1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Diphosphate-- 146-91-8target----

    10/90 Novoseek chemical compound relationships for RAC1 gene (see all 90)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 76.8 53 7980444 (5), 10893266 (3), 11900529 (2), 15242348 (2) (see all 27)
    nadph 76.1 128 11007780 (5), 9585526 (3), 19344766 (3), 18658277 (3) (see all 85)
    gtp 69.6 72 7980444 (3), 10893266 (3), 10036235 (2), 12620811 (2) (see all 40)
    phosphatidylinositol 67.3 48 9488489 (3), 19473989 (2), 10594018 (2), 15836616 (2) (see all 34)
    mdi-a 65.8 1 12445462 (1)
    diphenyleneiodonium 63.2 8 17008589 (1), 16990552 (1), 10747906 (1), 18218673 (1) (see all 5)
    geranylgeranyl pyrophosphate 62.4 6 16873994 (2), 17556673 (1), 15701825 (1), 17279352 (1)
    tyrosine 61.2 48 8816388 (2), 19366706 (2), 17093062 (2), 9430636 (1) (see all 38)
    phosphoinositide 59.6 23 17140407 (3), 11278419 (2), 19723872 (2), 11805146 (1) (see all 12)
    guanosine 59 14 19645540 (2), 17954607 (1), 10871853 (1), 15521546 (1) (see all 11)

    Search CenterWatch for drugs/clinical trials and news about RAC1 

    Transcripts
    for RAC1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RAC1 gene (3 alternative transcripts): 
    NM_006908.4  NM_018890.3  NM_198829.1  

    Unigene Cluster for RAC1:

    Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
    Hs.413812  [show with all ESTs]
    Unigene Representative Sequence: AB209410
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000348035(uc003spw.3 uc003spx.3 uc021zzg.1) ENST00000356142
    ENST00000488373 ENST00000497741 ENST00000473564 ENST00000495499

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): RAC1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAC1
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate RAC1 (see all 26):
    hsa-miR-3128 hsa-miR-320a hsa-miR-142-3p hsa-miR-137 hsa-miR-429 hsa-miR-485-3p hsa-miR-1271 hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmid: RAC1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAC1 (see all 7)
    OriGene siRNA: RAC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAC1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAC1 (see all 5)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): RAC1 (NM_006908)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAC1 
    Primer
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    Additional cDNA sequence: 

    AB209410.1 AB451238.1 AB451363.1 AF136373.1 AF498964.1 AJ012502.1 AJ132694.1 AK054993.1 
    AK291806.1 AK291815.1 AY279384.1 BC004247.1 BC050687.1 BC107748.1 BT007121.1 D25274.1 
    M29870.1 M31467.1 U85236.1 

    24/39 DOTS entries (see all 39):

    DT.100858626  DT.100690590  DT.97864716  DT.100045437  DT.95159201  DT.91931125  DT.92466364  DT.99943990 
    DT.121127892  DT.92044118  DT.92466365  DT.92005684  DT.100690587  DT.92028822  DT.95159178  DT.100045435 
    DT.100690586  DT.121127905  DT.100690597  DT.121127838  DT.121245026  DT.100690595  DT.121127894  DT.121127955 

    24/1283 AceView cDNA sequences (see all 1283):

    F27873 BM821864 BQ685492 AI343856 CB124290 AK054993 BQ691793 AW008814 
    BQ671157 AI375450 BM353585 BQ575269 BU556521 BQ685708 AI921305 AI367926 
    CF129147 BQ927251 BI712530 AK122742 BQ688628 BM807126 BG431253 BQ882850 

    GeneLoc Exon Structure


    Expression
    for RAC1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATGACTTAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RAC1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/21 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 21) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbForelimb Dorsal MusclesMononuclear MyocytesSkeletal Muscle
    LimbForelimb Ventral MusclesMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Dorsal MuscleMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Ventral MuscleMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleThoracic Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Hypaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Primary Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Primary Hypaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteLumbar Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RAC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAC1

    SOURCE GeneReport for Unigene cluster: Hs.413812

    UniProtKB/Swiss-Prot: RAC1_HUMAN, P63000
    Tissue specificity: Isoform B is predominantly identified in skin and epithelial tissues from the intestinal tract. Its
    expression is elevated in colorectal tumors at various stages of neoplastic progression, as compared to their
    respective adjacent tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including RAC1 (see all 15): 
              Neurogenesis in human mouse rat
              Cytoskeleton Regulators in human mouse rat
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat
              Wound Healing in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAC1

    Orthologs
    for RAC1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAC1 gene from 8/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RAC11 ras-related C3 botulinum toxin substrate 1 (rho family, more 88.19(n)
    100(a)    		   395871  NM_205017.1  NP_990348.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RAC16
    		 --
    		 95(a)
    		 1 ↔ 1
    		 GL343507.1(107364-122407)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.265882 Xenopus laevis rac GTPase mRNA, complete cds 84.78(n)    AF174644.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc558232 similar to CEll Death abnormality CED-10, RAC related more 80.78(n)   393898  BC044501.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Rac13
    Rac21    		 cell proliferation GTPase3
    CG8556-PA1    		 91(a)
    (best of 4)3
    72.22(n)1
    89.58(a)1    		   3 61F53
    388311  NM_139864.21  NP_648121.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea ced-101 , 3 RAS-related protein3
    Protein CED-101    		 97(a)
    (best of 5)3
    68.59(n)1
    83.25(a)1    		   IV(3507381-3509495)3
    1771111  NM_067962.41  NP_500363.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons RAC31 Rac-like GTP-binding protein ARAC3 61.02(n)
    67.76(a)    		   829654  NM_001203987.1  NP_001190916.1 
    rice
    (Oryza sativa)    		 Liliopsida Os02g08340001 hypothetical protein 61.14(n)
    66.85(a)    		   4331272  NM_001055174.1  NP_001048639.1 


    ENSEMBL Gene Tree for RAC1 (if available)
    TreeFam Gene Tree for RAC1 (if available) 

    Paralogs
    for RAC1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAC1 gene
    RHOH2  RHOQ2  RHOBTB12  RHOV2  RHOG2  RHOU2  RHOBTB22  RAC22  
    CDC422  RHOJ2  RAC32  
    18/40 SIMAP similar genes for RAC1 using alignment to 4 protein entries:     RAC1_HUMAN (see all proteins) (see all similar genes):
    RAC3    RAC2    CDC42    ARHG    RHOG    RHOJ
    RHOQ    RHOV    RHOD    RHOF    RHOU    RHOB
    RHOC    RHOH    RND2    RHOA    ARHE    ARHH

    RAC1 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for RAC1
    PGOHUM00000234900 PGOHUM00000244483 PGOHUM00000237589 PGOHUM00000232968 PGOHUM00000233232


    Genomic Variants
    for RAC1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/843 NCBI SNPs in RAC1 are shown (see all 843)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1126921761,2
    		--6285425(+) TTCACC/TGTCTA 2 -- us2k12Minor allele frequency- T:0.02CSA WA 120
    rs1174309221,2
    		C,F,--6286023(+) AGTTAG/TTGACA 2 -- us2k11Minor allele frequency- T:0.02NA 120
    rs43973031,2
    		C,--6286136(+) CACTGC/AAACCT 2 -- us2k13Minor allele frequency- A:0.18WA NA 240
    rs102324091,2
    		C,--6286905(+) tgttgC/Gccagg 2 -- us2k10--------
    rs358875291,2
    		C,F,--6287024(+) CTGAGT/CCCCAG 2 -- us2k18Minor allele frequency- C:0.18NS WA NA 424
    rs349328011,2
    		C,F,--6287191(+) GGCGGG/CAGCGG 2 -- us2k16Minor allele frequency- C:0.32NS EA 308
    rs23033631,2
    		C,F,--6287658(+) GGGGCC/TGCGGG 2 -- int15Minor allele frequency- T:0.17NS 190
    rs359224171,2
    		C,F,H--6287720(+) GCTCTC/TGATGG 2 -- int18Minor allele frequency- T:0.01NS NA 658
    rs357672641,2
    		C,--6287773(+) CCACCC/GTCCGG 2 -- int15Minor allele frequency- G:0.01NS 190
    rs350250401,2
    		C,F,--6287821(+) GCGCTC/TGTAGA 2 -- int15Minor allele frequency- T:0.01NS 184

    HapMap Linkage Disequilibrium report for RAC1 (6414126 - 6443608 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RAC1
         1 Inversion: 37290
    Human Gene Mutation Database (HGMD): RAC1

    1 SABiosciences Cancer Mutation PCR Assay for RAC1:
    Cosmic IdAA Change
    125734p.P29S
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAC1
    DNA2.0 Custom Variant and Variant Library Synthesis for RAC1

    Disorders / Diseases
    for RAC1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RAC1 for disorders           About GeneDecksing

    OMIM gene information: 602048    OMIM disorders: --

    20/96 diseases for RAC1 (see all 96):    About MalaCards
    wiskott-aldrich syndrome    familial adenomatous polyposis    amyotrophic lateral sclerosis (als)    amyotrophic lateral sclerosis
    clostridium difficile    non-hodgkin lymphoma    myotonic dystrophy    lateral sclerosis
    bullous pemphigoid    pituitary adenoma    hairy cell leukemia    chronic granulomatous disease
    oral squamous cell carcinoma    atrial fibrillation    malignant glioma    squamous cell carcinoma
    hodgkin's lymphoma    pancreatic ductal adenocarcinoma    synovial sarcoma    tangier disease

    2 diseases from the University of Copenhagen DISEASES database for RAC1:
    Cancer     Vascular disease

    10/57 Novoseek disease relationships for RAC1 gene (see all 57)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 49.2 4 11493455 (1), 11179351 (1), 11865026 (1)
    metastasis 40.9 33 20426825 (4), 17049467 (3), 17631638 (1), 19276387 (1) (see all 22)
    tumors 38 88 10636882 (4), 20426825 (4), 11606575 (3), 10893266 (3) (see all 47)
    colorectal tumors 27.5 8 16551621 (1), 18165265 (1), 10597294 (1), 11768613 (1)
    cancer 25.2 14 20067638 (2), 15160999 (1), 14530271 (1), 15067337 (1) (see all 10)
    glioblastoma 24.3 9 18813807 (4), 14736526 (1), 16027728 (1), 11929835 (1)
    astrocytoma 18.5 7 14736526 (2), 16204049 (2), 15242348 (1), 17896341 (1) (see all 5)
    pancreatic tumor 16.5 1 12902401 (1)
    glomerulosclerosis 13.6 1 16690620 (1)
    melanoma 13.1 14 12482591 (2), 17952876 (2), 11571298 (1), 15059909 (1) (see all 9)

    Human Genome Epidemiology (HuGE) Navigator: RAC1 (15 documents)

    Export disorders for RAC1 gene to outside databases

    Publications
    for RAC1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAC1 gene, integrated from 9 sources (see all 1340):
    (articles sorted by number of sources associating them with RAC1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors. (PubMed id 10597294)1, 2, 3, 9 Jordan P....Chastre E. (1999)
    2. Rac, a novel ras-related family of proteins that are botulinum toxin substrates. (PubMed id 2674130)1, 2, 3 Didsbury J.... Snyderman R. (1989)
    3. Armus is a Rac1 effector that inactivates Rab7 and re gulates E-cadherin degradation. (PubMed id 20116244)1, 2, 9 Frasa M.A....Braga V.M. (2010)
    4. Crystal structure of the Rac1-RhoGDI complex involved in NADPH oxidase activation. (PubMed id 11513578)1, 2, 9 Grizot S....Pebay-Peyroula E. (2001)
    5. The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling. (PubMed id 12612085)1, 2, 9 Masuda-Robens J.M....Chou M.M. (2003)
    6. Cooperation of DEF6 with activated Rac in regulating cell morphology. (PubMed id 17121847)1, 2, 9 Oka T.... Fukui Y. (2007)
    7. Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1. (PubMed id 11130063)1, 2, 9 Worthylake D.K.... Sondek J. (2000)
    8. Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA. (PubMed id 1903399)1, 2, 9 Kinsella B.T.... Maltese W.A. (1991)
    9. The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1. (PubMed id 22036506)1, 2 Torrino S.... Lemichez E. (2011)
    10. The SWI/SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein Unkempt. (PubMed id 20148946)1, 2 LorA"s P....Gacon G. (2010)

    External Searches for RAC1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RAC1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5879 HGNC: 9801 AceView: RAC1 Ensembl:ENSG00000136238 euGenes: HUgn5879
    ECgene: RAC1 Kegg: 5879 H-InvDB: RAC1

    Other Databases showing RAC1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RAC1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAC1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rac1/

    Intellectual Property
    for RAC1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RAC1 gene:
    Search GeneIP for patents involving RAC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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     Regulatory tfbs in RAC1 promoter
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
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     See all of Abcam's Antibodies, Kits and Proteins for RAC1
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     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAC1
     SwitchGear 3'UTR luciferase reporter plasmids for RAC1
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     ThermoFisher Antibody for RAC1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAC1
           
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