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Aliases for RABL6 Gene

Aliases for RABL6 Gene

  • RAB, Member RAS Oncogene Family-Like 6 2 3
  • Partner Of ARF 2 3 4
  • C9orf86 3 4 6
  • PARF 3 4 6
  • Rab-Like Protein 1 2 4
  • RBEL1 3 4
  • Chromosome 9 Open Reading Frame 86 2
  • Putative GTP-Binding Protein Parf 3
  • Rab-Like GTP-Binding Protein 1C 3
  • GTP-Binding Protein Parf 4
  • Rab-Like Protein 6 3
  • Pp8875 3

External Ids for RABL6 Gene

Previous HGNC Symbols for RABL6 Gene

  • C9orf86

Previous GeneCards Identifiers for RABL6 Gene

  • GC09P139702

Summaries for RABL6 Gene

Entrez Gene Summary for RABL6 Gene

  • This gene encodes a member of the Ras superfamily of small GTPases. The encoded protein binds to both GTP and GDP and may play a role in cell growth and survival. Overexpression of this gene may play a role in breast cancer tumorigenesis, and pseudogenes of this gene are located on the long arm of chromosome 2 and the short arm of chromosome 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for RABL6 Gene

RABL6 (RAB, Member RAS Oncogene Family-Like 6) is a Protein Coding gene. Diseases associated with RABL6 include breast cancer. GO annotations related to this gene include GTP binding.

UniProtKB/Swiss-Prot for RABL6 Gene

  • May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A.

Gene Wiki entry for RABL6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RABL6 Gene

Genomics for RABL6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RABL6 Gene

Start:
136,807,922 bp from pter
End:
136,957,733 bp from pter
Size:
149,812 bases
Orientation:
Plus strand

Genomic View for RABL6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RABL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RABL6 Gene

No data available for Regulatory Elements for RABL6 Gene

Proteins for RABL6 Gene

  • Protein details for RABL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3YEC7-RABL6_HUMAN
    Recommended name:
    Rab-like protein 6
    Protein Accession:
    Q3YEC7
    Secondary Accessions:
    • A8QVZ7
    • A8QVZ8
    • C6K8I4
    • C6K8I5
    • Q4F968
    • Q5T5R7
    • Q8IWK1
    • Q8TCL4
    • Q8WU94
    • Q96SR8
    • Q9BU21
    • Q9H935

    Protein attributes for RABL6 Gene

    Size:
    729 amino acids
    Molecular mass:
    79549 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH02945.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH21095.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH35786.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14408.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55213.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RABL6 Gene

neXtProt entry for RABL6 Gene

Proteomics data for RABL6 Gene at MOPED

Post-translational modifications for RABL6 Gene

  • Isoform 1 is O-glycosylated, while other isoforms are not.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RABL6 Gene

Domains for RABL6 Gene

Protein Domains for RABL6 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q3YEC7

UniProtKB/Swiss-Prot:

RABL6_HUMAN :
  • Q3YEC7
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RABL6: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for RABL6 Gene

Function for RABL6 Gene

Molecular function for RABL6 Gene

UniProtKB/Swiss-Prot Function: May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A.

Gene Ontology (GO) - Molecular Function for RABL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12646258
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RABL6: view

Phenotypes for RABL6 Gene

genes like me logo Genes that share phenotypes with RABL6: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RABL6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RABL6 Gene

Localization for RABL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RABL6 Gene

Isoform 1: Cytoplasm. Note=Predominantly cytoplasmic.
Isoform 3: Nucleus. Note=Predominantly nuclear.

Gene Ontology (GO) - Cellular Components for RABL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with RABL6: view

No data available for Subcellular locations from COMPARTMENTS for RABL6 Gene

Pathways for RABL6 Gene

SuperPathways for RABL6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RABL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport --
genes like me logo Genes that share ontologies with RABL6: view

No data available for Pathways by source for RABL6 Gene

Transcripts for RABL6 Gene

Unigene Clusters for RABL6 Gene

RAB, member RAS oncogene family-like 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RABL6

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RABL6 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - - - - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - -
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - - - -
SP13:
SP14:
SP15: - -
SP16:
SP17:

ExUns: 18 ^ 19 ^ 20a · 20b · 20c ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b · 25c ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b ^ 33
SP1:
SP2:
SP3: - - - - - - - -
SP4:
SP5:
SP6: - -
SP7: - -
SP8: - - -
SP9: - -
SP10:
SP11: - -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for RABL6 Gene

GeneLoc Exon Structure for
RABL6
ECgene alternative splicing isoforms for
RABL6

Expression for RABL6 Gene

mRNA expression in normal human tissues for RABL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RABL6 Gene

SOURCE GeneReport for Unigene cluster for RABL6 Gene Hs.370555

genes like me logo Genes that share expressions with RABL6: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RABL6 Gene

Orthologs for RABL6 Gene

This gene was present in the common ancestor of animals.

Orthologs for RABL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RABL6 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RABL6 35
  • 80.95 (n)
  • 78.43 (a)
RABL6 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RABL6 35
  • 81.75 (n)
  • 79.13 (a)
RABL6 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rabl6 35
  • 77.34 (n)
  • 78.51 (a)
Rabl6 16
Rabl6 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RABL6 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RABL6 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rabl6 35
  • 78.35 (n)
  • 79.22 (a)
chicken
(Gallus gallus)
Aves RABL6 35
  • 69.95 (n)
  • 70.63 (a)
RABL6 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RABL6 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8790 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rabl6 35
  • 66.33 (n)
  • 62.97 (a)
Str.4978 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13972 35
zebrafish
(Danio rerio)
Actinopterygii rabl6 36
  • 58 (a)
OneToMany
RABL6 (1 of 2) 36
  • 56 (a)
OneToMany
si:ch211-102c2.5 35
  • 62.14 (n)
  • 61.4 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012348 35
  • 60.37 (n)
  • 52.22 (a)
worm
(Caenorhabditis elegans)
Secernentea F08G12.1 36
  • 34 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7104 36
  • 39 (a)
OneToOne
Species with no ortholog for RABL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RABL6 Gene

ENSEMBL:
Gene Tree for RABL6 (if available)
TreeFam:
Gene Tree for RABL6 (if available)

Paralogs for RABL6 Gene

Selected SIMAP similar genes for RABL6 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RABL6: view

No data available for Paralogs for RABL6 Gene

Variants for RABL6 Gene

Sequence variations from dbSNP and Humsavar for RABL6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2247643 -- 136,823,321(-) CTGGC(A/G)GCACA intron-variant
rs2484661 -- 136,815,524(-) GTGTC(A/G)AGGCA intron-variant
rs2784082 -- 136,838,420(-) GGAGG(C/T)GGCTC intron-variant
rs2784083 -- 136,836,278(-) GAGCC(G/T)CCCTC intron-variant
rs2784089 -- 136,824,753(-) CTGTT(A/C)CTGCA intron-variant

Relevant External Links for RABL6 Gene

HapMap Linkage Disequilibrium report
RABL6
Human Gene Mutation Database (HGMD)
RABL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RABL6 Gene

Disorders for RABL6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RABL6 Gene including...

Search for RABL6 Gene in MalaCards »
genes like me logo Genes that share disorders with RABL6: view

No data available for UniProtKB/Swiss-Prot for RABL6 Gene

Publications for RABL6 Gene

  1. Identification and characterization of RBEL1 subfamily of GTPases in the Ras superfamily involved in cell growth regulation. (PMID: 19433581) Montalbano J. … Huang Y. (J. Biol. Chem. 2009) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4
  3. Identification of novel ARF binding proteins by two-hybrid screening. (PMID: 16582619) Tompkins V. … Quelle D.E. (Cell Cycle 2006) 2 3 4
  4. RBEL1 is a novel gene that encodes a nucleocytoplasmic Ras superfamily GTP-binding protein and is overexpressed in breast cancer. (PMID: 17962191) Montalbano J. … Huang Y. (J. Biol. Chem. 2007) 2 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for RABL6 Gene

Sources for RABL6 Gene

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