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Aliases for RABL6 Gene

Aliases for RABL6 Gene

  • RAB, Member RAS Oncogene Family-Like 6 5 2 3
  • Partner Of ARF 2 3 4
  • Rab-Like Protein 1 2 4
  • C9orf86 3 4
  • RBEL1 3 4
  • PARF 3 4
  • Chromosome 9 Open Reading Frame 86 2
  • Putative GTP-Binding Protein Parf 3
  • Rab-Like GTP-Binding Protein 1C 3
  • GTP-Binding Protein Parf 4
  • Pp8875 3

External Ids for RABL6 Gene

Previous HGNC Symbols for RABL6 Gene

  • C9orf86

Previous GeneCards Identifiers for RABL6 Gene

  • GC09P139702

Summaries for RABL6 Gene

Entrez Gene Summary for RABL6 Gene

  • This gene encodes a member of the Ras superfamily of small GTPases. The encoded protein binds to both GTP and GDP and may play a role in cell growth and survival. Overexpression of this gene may play a role in breast cancer tumorigenesis, and pseudogenes of this gene are located on the long arm of chromosome 2 and the short arm of chromosome 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for RABL6 Gene

RABL6 (RAB, Member RAS Oncogene Family-Like 6) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is ENSG00000282955.

UniProtKB/Swiss-Prot for RABL6 Gene

  • May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A.

Gene Wiki entry for RABL6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RABL6 Gene

Genomics for RABL6 Gene

Regulatory Elements for RABL6 Gene

Promoters for RABL6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RABL6 on UCSC Golden Path with GeneCards custom track

Genomic Location for RABL6 Gene

Chromosome:
9
Start:
136,807,922 bp from pter
End:
136,957,733 bp from pter
Size:
149,812 bases
Orientation:
Plus strand

Genomic View for RABL6 Gene

Genes around RABL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RABL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RABL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RABL6 Gene

Proteins for RABL6 Gene

  • Protein details for RABL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3YEC7-RABL6_HUMAN
    Recommended name:
    Rab-like protein 6
    Protein Accession:
    Q3YEC7
    Secondary Accessions:
    • A8QVZ7
    • A8QVZ8
    • C6K8I4
    • C6K8I5
    • Q4F968
    • Q5T5R7
    • Q8IWK1
    • Q8TCL4
    • Q8WU94
    • Q96SR8
    • Q9BU21
    • Q9H935

    Protein attributes for RABL6 Gene

    Size:
    729 amino acids
    Molecular mass:
    79549 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH02945.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH21095.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH35786.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14408.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55213.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RABL6 Gene

neXtProt entry for RABL6 Gene

Proteomics data for RABL6 Gene at MOPED

Post-translational modifications for RABL6 Gene

  • Isoform 1 is O-glycosylated, while other isoforms are not.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for RABL6 Gene

Domains & Families for RABL6 Gene

Gene Families for RABL6 Gene

Protein Domains for RABL6 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q3YEC7

UniProtKB/Swiss-Prot:

RABL6_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RABL6: view

Function for RABL6 Gene

Molecular function for RABL6 Gene

UniProtKB/Swiss-Prot Function:
May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A.

Gene Ontology (GO) - Molecular Function for RABL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12646258
genes like me logo Genes that share ontologies with RABL6: view
genes like me logo Genes that share phenotypes with RABL6: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RABL6 Gene

Localization for RABL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RABL6 Gene

Isoform 1: Cytoplasm. Note=Predominantly cytoplasmic (PubMed:17962191).
Isoform 3: Nucleus. Note=Predominantly nuclear (PubMed:17962191).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RABL6 Gene COMPARTMENTS Subcellular localization image for RABL6 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for RABL6 Gene

Pathways & Interactions for RABL6 Gene

SuperPathways for RABL6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RABL6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RABL6 Gene

Drugs & Compounds for RABL6 Gene

No Compound Related Data Available

Transcripts for RABL6 Gene

Unigene Clusters for RABL6 Gene

RAB, member RAS oncogene family-like 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RABL6 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - - - - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - -
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - - - -
SP13:
SP14:
SP15: - -
SP16:
SP17:

ExUns: 18 ^ 19 ^ 20a · 20b · 20c ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b · 25c ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b ^ 33
SP1:
SP2:
SP3: - - - - - - - -
SP4:
SP5:
SP6: - -
SP7: - -
SP8: - - -
SP9: - -
SP10:
SP11: - -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for RABL6 Gene

GeneLoc Exon Structure for
RABL6
ECgene alternative splicing isoforms for
RABL6

Expression for RABL6 Gene

mRNA expression in normal human tissues for RABL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RABL6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.5) and Pancreas (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RABL6 Gene



SOURCE GeneReport for Unigene cluster for RABL6 Gene Hs.370555

genes like me logo Genes that share expression patterns with RABL6: view

Protein tissue co-expression partners for RABL6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RABL6 Gene

Orthologs for RABL6 Gene

This gene was present in the common ancestor of animals.

Orthologs for RABL6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RABL6 35
  • 80.95 (n)
  • 78.43 (a)
RABL6 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RABL6 35
  • 81.75 (n)
  • 79.13 (a)
RABL6 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rabl6 35
  • 77.34 (n)
  • 78.51 (a)
Rabl6 16
Rabl6 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rabl6 35
  • 78.35 (n)
  • 79.22 (a)
oppossum
(Monodelphis domestica)
Mammalia RABL6 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RABL6 36
  • 50 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RABL6 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves RABL6 35
  • 69.95 (n)
  • 70.63 (a)
RABL6 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RABL6 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rabl6 35
  • 66.33 (n)
  • 62.97 (a)
Str.4978 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8790 35
zebrafish
(Danio rerio)
Actinopterygii si:ch211-102c2.5 35
  • 62.14 (n)
  • 61.4 (a)
rabl6 36
  • 58 (a)
OneToMany
RABL6 (1 of 2) 36
  • 56 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13972 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012348 35
  • 60.37 (n)
  • 52.22 (a)
worm
(Caenorhabditis elegans)
Secernentea F08G12.1 36
  • 34 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7104 36
  • 39 (a)
OneToOne
Species with no ortholog for RABL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RABL6 Gene

ENSEMBL:
Gene Tree for RABL6 (if available)
TreeFam:
Gene Tree for RABL6 (if available)

Paralogs for RABL6 Gene

Paralogs for RABL6 Gene

(1) SIMAP similar genes for RABL6 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RABL6: view

Variants for RABL6 Gene

Sequence variations from dbSNP and Humsavar for RABL6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs2811741 - 136,837,879(-) GCCCT(C/G)TGCGG reference, missense
rs2811722 -- 136,811,635(+) aaaaa(A/C)aaTTg intron-variant
rs2811723 -- 136,812,554(+) ACTTC(A/G)TCTTA intron-variant
rs2811740 -- 136,838,010(-) CTGTC(A/G)CTGTC reference, synonymous-codon
rs2811742 -- 136,837,517(-) GGGGC(A/G)GCATT reference, synonymous-codon

Variation tolerance for RABL6 Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.78; 47.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RABL6 Gene

HapMap Linkage Disequilibrium report
RABL6
Human Gene Mutation Database (HGMD)
RABL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RABL6 Gene

Disorders for RABL6 Gene

Relevant External Links for RABL6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RABL6

No disorders were found for RABL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RABL6 Gene

Publications for RABL6 Gene

  1. Identification and characterization of RBEL1 subfamily of GTPases in the Ras superfamily involved in cell growth regulation. (PMID: 19433581) Montalbano J. … Huang Y. (J. Biol. Chem. 2009) 2 3 4 67
  2. RBEL1 is a novel gene that encodes a nucleocytoplasmic Ras superfamily GTP-binding protein and is overexpressed in breast cancer. (PMID: 17962191) Montalbano J. … Huang Y. (J. Biol. Chem. 2007) 2 3
  3. Identification of novel ARF binding proteins by two-hybrid screening. (PMID: 16582619) Tompkins V. … Quelle D.E. (Cell Cycle 2006) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for RABL6 Gene

Sources for RABL6 Gene

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