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Aliases for RABL3 Gene

Aliases for RABL3 Gene

  • RAB, Member Of RAS Oncogene Family Like 3 2 3 5
  • RAB, Member Of RAS Oncogene Family-Like 3 2

External Ids for RABL3 Gene

Previous GeneCards Identifiers for RABL3 Gene

  • GC00U991171
  • GC03M121728
  • GC03M121726
  • GC03M121888
  • GC03M120405
  • GC03M117779

Summaries for RABL3 Gene

GeneCards Summary for RABL3 Gene

RABL3 (RAB, Member Of RAS Oncogene Family Like 3) is a Protein Coding gene. GO annotations related to this gene include GTP binding and GTPase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RABL3 Gene

Genomics for RABL3 Gene

Regulatory Elements for RABL3 Gene

Enhancers for RABL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F120774 1 FANTOM5 11.8 -31.9 -31904 0.5 GTF2E1 RABL3 HGD NAP1L1P3
GH03F120595 0.5 ENCODE 11.2 +146.4 146355 2.6 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF143 SP5 GTF2E1 RABL3 NDUFB4 PIR48626
GH03F120641 1.2 FANTOM5 Ensembl ENCODE 11.1 +100.4 100364 1.4 HDAC1 ATF1 TBL1XR1 NFRKB FOS CREM REST SMARCA4 IKZF1 HMBOX1 HGD GTF2E1 RABL3 PIR48626
GH03F120791 1.2 Ensembl ENCODE 6 -49.3 -49299 1.7 JUND ATF3 JUN IKZF1 FOS HGD RABL3 GTF2E1 NAP1L1P3
GH03F120677 1.4 FANTOM5 Ensembl ENCODE 4.5 +62.4 62378 5.8 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 PAF1 NFYC MXD4 RABL3 HGD PIR48626
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RABL3 on UCSC Golden Path with GeneCards custom track

Promoters for RABL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001482820 492 2600 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143

Genomic Location for RABL3 Gene

Chromosome:
3
Start:
120,686,681 bp from pter
End:
120,742,993 bp from pter
Size:
56,313 bases
Orientation:
Minus strand

Genomic View for RABL3 Gene

Genes around RABL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RABL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RABL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RABL3 Gene

Proteins for RABL3 Gene

  • Protein details for RABL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5HYI8-RABL3_HUMAN
    Recommended name:
    Rab-like protein 3
    Protein Accession:
    Q5HYI8
    Secondary Accessions:
    • Q8WUD3

    Protein attributes for RABL3 Gene

    Size:
    236 amino acids
    Molecular mass:
    26423 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RABL3 Gene

Post-translational modifications for RABL3 Gene

  • Ubiquitination at Lys 231
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RABL3 Gene

Domains & Families for RABL3 Gene

Gene Families for RABL3 Gene

Protein Domains for RABL3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RABL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5HYI8

UniProtKB/Swiss-Prot:

RABL3_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RABL3: view

Function for RABL3 Gene

Gene Ontology (GO) - Molecular Function for RABL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RABL3: view
genes like me logo Genes that share phenotypes with RABL3: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RABL3 Gene

Localization for RABL3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RABL3 Gene COMPARTMENTS Subcellular localization image for RABL3 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for RABL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with RABL3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RABL3 Gene

Pathways & Interactions for RABL3 Gene

SuperPathways for RABL3 Gene

No Data Available

Interacting Proteins for RABL3 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000273375%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000324804%0d%0a9606.ENSP00000335579%0d%0a9606.ENSP00000311344%0d%0a9606.ENSP00000411584%0d%0a
Selected Interacting proteins: Q5HYI8-RABL3_HUMAN ENSP00000273375 for RABL3 Gene via IID STRING

Gene Ontology (GO) - Biological Process for RABL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with RABL3: view

No data available for Pathways by source and SIGNOR curated interactions for RABL3 Gene

Transcripts for RABL3 Gene

Unigene Clusters for RABL3 Gene

RAB, member of RAS oncogene family-like 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RABL3 Gene

No ASD Table

Relevant External Links for RABL3 Gene

GeneLoc Exon Structure for
RABL3
ECgene alternative splicing isoforms for
RABL3

Expression for RABL3 Gene

mRNA expression in normal human tissues for RABL3 Gene

Protein differential expression in normal tissues from HIPED for RABL3 Gene

This gene is overexpressed in Bone (41.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RABL3 Gene



Protein tissue co-expression partners for RABL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RABL3 Gene:

RABL3

SOURCE GeneReport for Unigene cluster for RABL3 Gene:

Hs.444360
genes like me logo Genes that share expression patterns with RABL3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RABL3 Gene

Orthologs for RABL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RABL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RABL3 34 35
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia RABL3 34 35
  • 94.63 (n)
cow
(Bos Taurus)
Mammalia RABL3 34 35
  • 93.64 (n)
oppossum
(Monodelphis domestica)
Mammalia RABL3 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RABL3 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rabl3 34 16 35
  • 89.12 (n)
rat
(Rattus norvegicus)
Mammalia Rabl3 34
  • 87.85 (n)
chicken
(Gallus gallus)
Aves RABL3 34 35
  • 81.36 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 86 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rabl3 34
  • 74.04 (n)
Str.13474 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15449 34
zebrafish
(Danio rerio)
Actinopterygii rabl3 34 35
  • 73.53 (n)
Dr.27288 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13370 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006354 34
  • 57.19 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4789 34 35
  • 50.59 (n)
CG15399 35
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_Y116A8C.10 34
  • 44.61 (n)
Y116A8C.10 35
  • 30 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G09910 34
  • 46.7 (n)
rice
(Oryza sativa)
Liliopsida Os10g0135200 34
  • 45.53 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.610 35
  • 46 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4393 34
Species where no ortholog for RABL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RABL3 Gene

ENSEMBL:
Gene Tree for RABL3 (if available)
TreeFam:
Gene Tree for RABL3 (if available)

Paralogs for RABL3 Gene

(1) SIMAP similar genes for RABL3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RABL3: view

No data available for Paralogs for RABL3 Gene

Variants for RABL3 Gene

Sequence variations from dbSNP and Humsavar for RABL3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10511401 -- 120,730,877(-) CTTAA(C/T)ATTAT intron-variant
rs10541119 -- 120,696,593(+) GAATA(-/AC)ACACA intron-variant
rs10576070 -- 120,731,114(+) CTCAC(-/TT)TGAGA intron-variant
rs1062355 -- 120,688,250(-) GGGAA(G/T)TAGAA utr-variant-3-prime
rs10934532 -- 120,702,619(+) gtggc(A/G)tgatc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RABL3 Gene

Variant ID Type Subtype PubMed ID
dgv4847n100 CNV gain 25217958
esv1608308 CNV insertion 17803354
esv3392544 CNV insertion 20981092
nsv1139153 CNV deletion 24896259
nsv829699 CNV loss 17160897
nsv965203 CNV duplication 23825009

Variation tolerance for RABL3 Gene

Residual Variation Intolerance Score: 31.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RABL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RABL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RABL3 Gene

Disorders for RABL3 Gene

Relevant External Links for RABL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RABL3

No disorders were found for RABL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RABL3 Gene

Publications for RABL3 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
  4. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for RABL3 Gene

Sources for RABL3 Gene

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