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Aliases for RABL3 Gene

Aliases for RABL3 Gene

  • RAB, Member Of RAS Oncogene Family-Like 3 2 3

External Ids for RABL3 Gene

Summaries for RABL3 Gene

GeneCards Summary for RABL3 Gene

RABL3 (RAB, Member Of RAS Oncogene Family-Like 3) is a Protein Coding gene. GO annotations related to this gene include GTP binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RABL3 Gene

Genomics for RABL3 Gene

Genomic Location for RABL3 Gene

Start:
120,686,681 bp from pter
End:
120,742,993 bp from pter
Size:
56,313 bases
Orientation:
Minus strand

Genomic View for RABL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RABL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RABL3 Gene

Regulatory Elements for RABL3 Gene

Proteins for RABL3 Gene

  • Protein details for RABL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5HYI8-RABL3_HUMAN
    Recommended name:
    Rab-like protein 3
    Protein Accession:
    Q5HYI8
    Secondary Accessions:
    • Q8WUD3

    Protein attributes for RABL3 Gene

    Size:
    236 amino acids
    Molecular mass:
    26423 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RABL3 Gene

Proteomics data for RABL3 Gene at MOPED

Post-translational modifications for RABL3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys231

Other Protein References for RABL3 Gene

No data available for DME Specific Peptides for RABL3 Gene

Domains for RABL3 Gene

Protein Domains for RABL3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RABL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5HYI8

UniProtKB/Swiss-Prot:

RABL3_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rab family.:
    • Q5HYI8
genes like me logo Genes that share domains with RABL3: view

No data available for Gene Families for RABL3 Gene

Function for RABL3 Gene

Gene Ontology (GO) - Molecular Function for RABL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RABL3: view

miRNA for RABL3 Gene

miRTarBase miRNAs that target RABL3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RABL3 Gene

Localization for RABL3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RABL3 Gene COMPARTMENTS Subcellular localization image for RABL3 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for RABL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0012505 endomembrane system IBA --
genes like me logo Genes that share ontologies with RABL3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RABL3 Gene

Pathways for RABL3 Gene

SuperPathways for RABL3 Gene

No Data Available

Interacting Proteins for RABL3 Gene

Gene Ontology (GO) - Biological Process for RABL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0007264 small GTPase mediated signal transduction --
GO:0008152 metabolic process IBA --
GO:0015031 protein transport --
GO:0032482 Rab protein signal transduction IBA --
genes like me logo Genes that share ontologies with RABL3: view

No data available for Pathways by source for RABL3 Gene

Transcripts for RABL3 Gene

Unigene Clusters for RABL3 Gene

RAB, member of RAS oncogene family-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RABL3 Gene

No ASD Table

Relevant External Links for RABL3 Gene

GeneLoc Exon Structure for
RABL3
ECgene alternative splicing isoforms for
RABL3

Expression for RABL3 Gene

mRNA expression in normal human tissues for RABL3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RABL3 Gene

SOURCE GeneReport for Unigene cluster for RABL3 Gene Hs.444360

genes like me logo Genes that share expressions with RABL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RABL3 Gene

Orthologs for RABL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RABL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RABL3 35
  • 99.44 (n)
  • 100 (a)
RABL3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RABL3 35
  • 93.64 (n)
  • 97.03 (a)
RABL3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RABL3 35
  • 94.63 (n)
  • 97.88 (a)
RABL3 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rabl3 35
  • 89.12 (n)
  • 92.37 (a)
Rabl3 16
Rabl3 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RABL3 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RABL3 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rabl3 35
  • 87.85 (n)
  • 92.37 (a)
chicken
(Gallus gallus)
Aves RABL3 35
  • 81.36 (n)
  • 92.89 (a)
RABL3 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.15449 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rabl3 35
  • 74.04 (n)
  • 91.06 (a)
Str.13474 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13370 35
zebrafish
(Danio rerio)
Actinopterygii Dr.27288 35
rabl3 35
  • 73.53 (n)
  • 84.55 (a)
rabl3 36
  • 85 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006354 35
  • 57.19 (n)
  • 57.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15399 36
  • 26 (a)
OneToMany
CG4789 35
  • 50.59 (n)
  • 50.44 (a)
CG4789 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_Y116A8C.10 35
  • 44.61 (n)
  • 37.37 (a)
Y116A8C.10 36
  • 30 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G09910 35
  • 46.7 (n)
  • 35.94 (a)
rice
(Oryza sativa)
Liliopsida Os10g0135200 35
  • 45.53 (n)
  • 38.14 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4393 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.610 36
  • 46 (a)
OneToOne
Species with no ortholog for RABL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RABL3 Gene

ENSEMBL:
Gene Tree for RABL3 (if available)
TreeFam:
Gene Tree for RABL3 (if available)

Paralogs for RABL3 Gene

Selected SIMAP similar genes for RABL3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RABL3: view

No data available for Paralogs for RABL3 Gene

Variants for RABL3 Gene

Sequence variations from dbSNP and Humsavar for RABL3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1062355 -- 120,688,250(-) GGGAA(G/T)TAGAA utr-variant-3-prime
rs1862935 -- 120,686,613(-) TCTCC(A/G)CTACA downstream-variant-500B
rs2008682 -- 120,716,553(-) TACAT(C/G)TGCCA intron-variant
rs2059331 -- 120,689,243(-) AATGG(C/G)TCAGT utr-variant-3-prime
rs2288096 -- 120,690,679(-) GGCAG(A/G)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RABL3 Gene

Variant ID Type Subtype PubMed ID
nsv877377 CNV Gain 21882294
nsv829699 CNV Loss 17160897
nsv877378 CNV Gain 21882294
esv272448 CNV Insertion 20981092
esv271232 CNV Insertion 20981092
esv1608308 CNV Insertion 17803354

Relevant External Links for RABL3 Gene

HapMap Linkage Disequilibrium report
RABL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RABL3 Gene

Disorders for RABL3 Gene

No disorders were found for RABL3 Gene.

No data available for UniProtKB/Swiss-Prot for RABL3 Gene

Publications for RABL3 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Evaluation of the novel gene Rabl3 in the regulation of proliferation and motility in human cancer cells. (PMID: 20596630) Li Q. … Wang L. (Oncol. Rep. 2010) 3
  3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for RABL3 Gene

Sources for RABL3 Gene

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