RABL2B Gene
protein-coding GIFtS: 47
GCID: GC22M051205
|
|
RAB, member of RAS oncogene family-like 2B
| |
Aliases
for RABL2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RAB, Member Of RAS Oncogene Family-Like 2B1 2 | | Rab-Like Protein 2B2 |
Export aliases for RABL2B gene to outside databasesPrevious GC identifers: GC22M047709 GC22M049338 GC22M049496 GC22M049552 GC22M034098 |
Summaries
for RABL2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RABL2B:
The RABL2B protein is a member of the RAB gene family which belongs to the RAS GTPase superfamily. RABL2B is locatedwithin a subtelomeric region of 22q13.3. Multiple alternatively spliced transcript variants encoding several differentisoforms have been found for this gene. (provided by RefSeq, Aug 2008)
|
Genomic Views
for RABL2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011526.7
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RABL2B gene promoter:
GR RFX1 HOXA3 AML1a GR-beta MyoD XBP-1 STAT3 GR-alpha Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for RABL2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RABL2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.33 Ensembl cytogenetic band: 22q13.33 HGNC cytogenetic band: 22q13.33RABL2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M051205: view genomic region
(about GC identifiers)
Start:
|
51,205,920 bp from pter |
End:
|
51,222,091 bp from pter |
Size:
|
16,172 bases |
Orientation:
|
minus strand |
|
Proteins
for RABL2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RBL2B_HUMAN, Q9UNT1 (See
protein sequence)Recommended Name: Rab-like protein 2B Size: 228 amino acids; 26101 Da
Secondary accessions: Q5TZT8 Q96C33Alternative splicing: 3 isoforms: Q9UNT1-1 Q9UNT1-2 Q9UNT1-3 Explore the universe of human proteins at neXtProt for RABL2B: NX_Q9UNT1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UNT1
RABL2B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (7 alternative transcripts):
NP_001003789.1 NP_001124391.1 NP_001124392.1 NP_001124393.1 NP_001124394.1 NP_001124395.1 NP_009012.1
ENSEMBL proteins: ENSP00000346940 ENSP00000399988 ENSP00000378958 ENSP00000378962 ENSP00000378956 ENSP00000378960 ENSP00000398282 ENSP00000378955 ENSP00000419811 ENSP00000415180 ENSP00000401906
Human Recombinant Protein Products:
RABL2B Antibody Products:
Assay Products for RABL2B: |
Protein
Domains /
Families
for RABL2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RABL2B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UNT1ProtoNet protein and cluster: Q9UNT1 1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: RBL2B_HUMAN, Q9UNT1Similarity: Belongs to the small GTPase superfamily. Rab family |
Function
for RABL2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for RABL2B:RAB like gene 2B,ubiquitously expressed
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RABL2B (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RABL2B (see all 7)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RABL2B |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
RABL2B for ontologies About GeneDecksing
|
Pathways & Interactions
for RABL2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RABL2B
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for RABL2B (Q9UNT13 ENSP000003789584) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006184 | GTP catabolic process |
TAS | 10444334 | | GO:0007264 | small GTPase mediated signal transduction |
IEA | -- |
RABL2B for ontologies About GeneDecksing
|
Drugs & Compounds
for RABL2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RABL2B
Search CenterWatch for drugs/clinical trials and news about RABL2B / RBL2B
|
Transcripts
for RABL2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RABL2B gene (7 alternative transcripts): NM_001003789.1 NM_001130919.1 NM_001130920.1 NM_001130921.1 NM_001130922.1 NM_001130923.1 NM_007081.2 Unigene Cluster for RABL2B: RAB, member of RAS oncogene family-like 2B Hs.584862 [show with all ESTs]Unigene Representative Sequence: NM_00113092115 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000354869(uc011ase.1) ENST00000425098 ENST00000395593(uc003bnm.1 uc011asf.1)
ENST00000395598(uc003bnl.1) ENST00000395591 ENST00000395595(uc003bnn.1 uc003bnk.1 uc003bno.1 uc011asg.1)
ENST00000465063 ENST00000436958 ENST00000482308 ENST00000464678 ENST00000395590
ENST00000468451 ENST00000464740 ENST00000413505 ENST00000435118
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RABL2B (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RABL2B (see all 7)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 7): RABL2B (NM_001003789) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RABL2B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RABL2B |
Additional cDNA sequence: AF095352.1 AK308268.1 AK313442.1 BC014879.2 BC024281.1 BC064551.1 BC075856.1 BT020037.1 18 DOTS entries: DT.416812 DT.92367999 DT.95070954 DT.97826702 DT.100811987 DT.120643102 DT.100686799 DT.100767075 DT.95202323 DT.120643028 DT.120643036 DT.92327341 DT.120643030 DT.120643050 DT.120990781 DT.91994274 DT.92007456 DT.97813737 24/165 AceView cDNA sequences (see all 165): CD623641 AI701071 AW627731 NM_001003789 BQ710234 BC020495 CR617149 AI150466 AA435681 BQ710310 AA492273 BX432292 CR621508 AI887990 BC024281 AA804644 W68672 CN479444 BX430554 NM_007081 BM922664 AI624939 BQ101083 AL134509
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for RABL2B About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | - | | | | - | | | |
ECgene alternative splicing isoforms for RABL2B
|
Expression
for RABL2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RABL2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RABL2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RABL2B
SOURCE GeneReport for Unigene cluster: Hs.584862
SABiosciences Custom PCR Arrays for RABL2B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RABL2B
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RABL2B |
Orthologs
for RABL2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for RABL2B gene from 4/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RABL2B1 |
RAB, member of RAS oncogene family-like 2B |
72.42(n)
76.36(a) |
|
426865 XM_424473.3 XP_424473.1 |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
80(a) |
1 → many |
GL343765.1(58727-70024) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.255052 |
Xenopus laevis transcribed sequence with moderate similarity to protein spQ9UNT1 (H.sapiens) RB2A_HUMAN Rab-like protein 2A less |
76.65(n) |
|
BJ032133.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
rabl21 |
RAB, member of RAS oncogene family-like 2 |
71.72(n)
76.3(a) |
|
561568 NM_001044963.2 NP_001038428.1 |
ENSEMBL Gene Tree for RABL2B (if available)
TreeFam Gene Tree for RABL2B (if available) |
Paralogs
for RABL2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RABL2B gene
- RAN2 RABL2A2
18/66 SIMAP similar genes for RABL2B using alignment to 7 protein entries: RBL2B_HUMAN (see all proteins)
(see all similar genes):RABL2A RAB11A RAB4B RAB6A DKFZp686J07132 RAB41
RAB8B RAB30 RALA RALB RAB35 RAB11B
RAB15 RANP1 RAB7A RAB37 RAB9A RAB6B
RABL2B for paralogs About GeneDecksing
|
Genomic Variants
for RABL2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RABL2B (51205920 - 51222091 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RABL2B: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for RABL2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 RABL2B for disorders About MalaCards
RABL2B for disorders About GeneDecksing
OMIM gene information: 605413
OMIM disorders: --
Export disorders for RABL2B gene to outside databases
|
Publications
for RABL2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RABL2B gene integrated from 9 sources:
(articles sorted by number of sources associating them with RABL2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Two novel human RAB genes with near identical sequence each map to a telomere-associated region: the subtelomeric region of 22q13.3 and the ancestral telomere band 2q13. (PubMed id 10444334)1, 2, 3 Wong A.C....McDermid H.E. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- Analysis of relative gene dosage and expression diffe rences of the paralogs RABL2A and RABL2B by Pyrosequencing. (PubMed id 20138207)1 Kramer M....Huse K. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1 Collins J.E.... Dunham I. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Chromosome 22q13.3 deletion syndrome with a de novo i nterstitial 22q13.3 cryptic deletion disrupting SHANK3. (PubMed id 19454329)9 Delahaye A....Drunat S. (2009)
|
External Searches for RABL2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RABL2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RABL2B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RABL2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RABL2B gene:
Search GeneIP for patents involving RABL2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RABL2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RABL2B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RABL2B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RABL2B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RABL2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RABL2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RABL2B |
| |
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| |  |  |  |  | | | | |
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 | | | RABL2B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RABL2B |
|  |  |  | | | | Search ThermoFisher Antibodies for RABL2B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RABL2B |
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