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Aliases for RABL2B Gene

Aliases for RABL2B Gene

  • RAB, Member Of RAS Oncogene Family-Like 2B 2 3

External Ids for RABL2B Gene

Previous GeneCards Identifiers for RABL2B Gene

  • GC22M047709
  • GC22M049338
  • GC22M049496
  • GC22M049552
  • GC22M051205
  • GC22M034098

Summaries for RABL2B Gene

Entrez Gene Summary for RABL2B Gene

  • The RABL2B protein is a member of the RAB gene family which belongs to the RAS GTPase superfamily. RABL2B is located within a subtelomeric region of 22q13.3. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for RABL2B Gene

RABL2B (RAB, Member Of RAS Oncogene Family-Like 2B) is a Protein Coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB9A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RABL2B Gene

Genomics for RABL2B Gene

Regulatory Elements for RABL2B Gene

Genomic Location for RABL2B Gene

Start:
50,767,492 bp from pter
End:
50,783,675 bp from pter
Size:
16,184 bases
Orientation:
Minus strand

Genomic View for RABL2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RABL2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RABL2B Gene

Proteins for RABL2B Gene

  • Protein details for RABL2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNT1-RBL2B_HUMAN
    Recommended name:
    Rab-like protein 2B
    Protein Accession:
    Q9UNT1
    Secondary Accessions:
    • Q5TZT8
    • Q96C33

    Protein attributes for RABL2B Gene

    Size:
    228 amino acids
    Molecular mass:
    26101 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RABL2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RABL2B Gene

Proteomics data for RABL2B Gene at MOPED

Post-translational modifications for RABL2B Gene

  • Ubiquitination at Lys150 and Lys144
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RABL2B Gene

Domains for RABL2B Gene

Gene Families for RABL2B Gene

HGNC:
  • RAB :RAB, member RAS oncogene

Protein Domains for RABL2B Gene

Graphical View of Domain Structure for InterPro Entry

Q9UNT1

UniProtKB/Swiss-Prot:

RBL2B_HUMAN :
  • Q9UNT1
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RABL2B: view

Function for RABL2B Gene

Molecular function for RABL2B Gene

GENATLAS Biochemistry:
RAB like gene 2B,ubiquitously expressed

Gene Ontology (GO) - Molecular Function for RABL2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 10444334
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RABL2B: view

Animal Model Products

CRISPR Products

miRNA for RABL2B Gene

miRTarBase miRNAs that target RABL2B

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RABL2B Gene

Localization for RABL2B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RABL2B Gene COMPARTMENTS Subcellular localization image for RABL2B gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for RABL2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0012505 endomembrane system IBA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RABL2B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RABL2B Gene

Pathways for RABL2B Gene

SuperPathways for RABL2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RABL2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction --
genes like me logo Genes that share ontologies with RABL2B: view

No data available for Pathways by source for RABL2B Gene

Transcripts for RABL2B Gene

Unigene Clusters for RABL2B Gene

RAB, member of RAS oncogene family-like 2B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RABL2B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RABL2B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4
SP1:
SP2: - -

Relevant External Links for RABL2B Gene

GeneLoc Exon Structure for
RABL2B
ECgene alternative splicing isoforms for
RABL2B

Expression for RABL2B Gene

mRNA expression in normal human tissues for RABL2B Gene

SOURCE GeneReport for Unigene cluster for RABL2B Gene Hs.584862

mRNA Expression by UniProt/SwissProt for RABL2B Gene

Q9UNT1-RBL2B_HUMAN
Tissue specificity: Expressed in the testis.
genes like me logo Genes that share expressions with RABL2B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Expression partners for RABL2B Gene

Orthologs for RABL2B Gene

This gene was present in the common ancestor of animals.

Orthologs for RABL2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC515671 35
  • 87.03 (n)
  • 86.43 (a)
-- 36
  • 79 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC100685429 35
  • 88.84 (n)
  • 88.84 (a)
-- 36
  • 88 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RABL2B 35
  • 99.4 (n)
  • 99.1 (a)
-- 36
  • 98 (a)
ManyToMany
RABL2B 36
  • 99 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rabl2 36
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
OneToMany
chicken
(Gallus gallus)
Aves RABL2B 35
  • 72.42 (n)
  • 76.36 (a)
RABL2B 36
  • 75 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rabl2b 35
  • 71.01 (n)
  • 79.07 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25505 35
zebrafish
(Danio rerio)
Actinopterygii rabl2 35
  • 70.83 (n)
  • 75 (a)
rabl2 36
  • 74 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta RabX6 36
  • 23 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1851 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4950 36
  • 60 (a)
OneToMany
Species with no ortholog for RABL2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RABL2B Gene

ENSEMBL:
Gene Tree for RABL2B (if available)
TreeFam:
Gene Tree for RABL2B (if available)

Paralogs for RABL2B Gene

Paralogs for RABL2B Gene

genes like me logo Genes that share paralogs with RABL2B: view

Variants for RABL2B Gene

Relevant External Links for RABL2B Gene

HapMap Linkage Disequilibrium report
RABL2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for RABL2B Gene

Disorders for RABL2B Gene

No disorders were found for RABL2B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RABL2B Gene

Publications for RABL2B Gene

  1. Two novel human RAB genes with near identical sequence each map to a telomere-associated region: the subtelomeric region of 22q13.3 and the ancestral telomere band 2q13. (PMID: 10444334) Wong A.C. … McDermid H.E. (Genomics 1999) 2 3 4
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for RABL2B Gene

Sources for RABL2B Gene

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