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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RABL2B Gene

protein-coding   GIFtS: 44
GCID: GC22M051205

RAB, Member Of RAS Oncogene Family-Like 2B

  Search for RABL2B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAB, Member Of RAS Oncogene Family-Like 2B1 2
Rab-Like Protein 2B2

External Ids:    HGNC: 98001   Entrez Gene: 111582   Ensembl: ENSG000000799747   OMIM: 6054135   UniProtKB: Q9UNT13   

Export aliases for RABL2B gene to outside databases

Previous GC identifers: GC22M047709 GC22M049338 GC22M049496 GC22M049552 GC22M034098


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RABL2B Gene:
The RABL2B protein is a member of the RAB gene family which belongs to the RAS GTPase superfamily. RABL2B is
located within a subtelomeric region of 22q13.3. Multiple alternatively spliced transcript variants encoding
several different isoforms have been found for this gene. (provided by RefSeq, Aug 2008)

GeneCards Summary for RABL2B Gene: 
RABL2B (RAB, member of RAS oncogene family-like 2B) is a protein-coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB9A.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011526.7  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RABL2B gene promoter:
         GR   RFX1   HOXA3   AML1a   GR-beta   MyoD   XBP-1   STAT3   GR-alpha   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRABL2B promoter sequence
   Search SABiosciences Chromatin IP Primers for RABL2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RABL2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.33   Ensembl cytogenetic band:  22q13.33   HGNC cytogenetic band: 22q13.33

RABL2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RABL2B gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M051205:  view genomic region     (about GC identifiers)

Start:
51,205,920 bp from pter      End:
51,222,091 bp from pter
Size:
16,172 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RBL2B_HUMAN, Q9UNT1 (See protein sequence)
Recommended Name: Rab-like protein 2B  
Size: 228 amino acids; 26101 Da
Secondary accessions: Q5TZT8 Q96C33
Alternative splicing: 3 isoforms:  Q9UNT1-1   Q9UNT1-2   Q9UNT1-3   

Explore the universe of human proteins at neXtProt for RABL2B: NX_Q9UNT1

Explore proteomics data for RABL2B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UNT1

  • RABL2B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RABL2B Protein Expression
    REFSEQ proteins (7 alternative transcripts): 
    NP_001003789.1  NP_001124391.1  NP_001124392.1  NP_001124393.1  NP_001124394.1  NP_001124395.1  NP_009012.1  

    ENSEMBL proteins: 
     ENSP00000346940   ENSP00000399988   ENSP00000378958   ENSP00000378962   ENSP00000378956  
     ENSP00000378960   ENSP00000398282   ENSP00000378955   ENSP00000419811   ENSP00000415180  
     ENSP00000401906  

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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0016020membrane ----

    RABL2B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9UNT1

    ProtoNet protein and cluster: Q9UNT1

    1 Blocks protein domain: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RBL2B_HUMAN, Q9UNT1
    Similarity: Belongs to the small GTPase superfamily. Rab family


    RABL2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for RABL2B:
    RAB like gene 2B,ubiquitously expressed

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS10444334
    GO:0005525GTP binding IEA--
         
    RABL2B for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RABL2B

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for RABL2B (Q9UNT13 ENSP000003789584) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP19Q96LK03, ENSP000003872094I2D: score=4 STRING: ENSP00000387209
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS10444334
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--

    RABL2B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RABL2B (RBL2B)

    Search CenterWatch for drugs/clinical trials and news about RABL2B / RBL2B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RABL2B gene (7 alternative transcripts): 
    NM_001003789.1  NM_001130919.1  NM_001130920.1  NM_001130921.1  NM_001130922.1  NM_001130923.1  NM_007081.2  

    Unigene Cluster for RABL2B:

    RAB, member of RAS oncogene family-like 2B
    Hs.584862  [show with all ESTs]
    Unigene Representative Sequence: NM_001130921
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354869(uc011ase.1) ENST00000425098 ENST00000395593(uc003bnm.1 uc011asf.1)
    ENST00000395598(uc003bnl.1) ENST00000395591 ENST00000395595(uc003bnn.1 uc003bnk.1 uc003bno.1 uc011asg.1)
    ENST00000465063 ENST00000436958 ENST00000482308 ENST00000464678 ENST00000395590
    ENST00000468451 ENST00000464740 ENST00000413505 ENST00000435118
    miRNA
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    hsa-miR-767-3p hsa-miR-138
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    Additional mRNA sequence: 

    AF095352.1 AK308268.1 AK313442.1 BC014879.2 BC024281.1 BC064551.1 BC075856.1 BT020037.1 

    18 DOTS entries:

    DT.416812  DT.92367999  DT.95070954  DT.97826702  DT.100811987  DT.120643102  DT.100686799  DT.100767075 
    DT.95202323  DT.120643028  DT.120643036  DT.92327341  DT.120643030  DT.120643050  DT.120990781  DT.91994274 
    DT.92007456  DT.97813737 

    24/165 AceView cDNA sequences (see all 165):

    W80659 BQ101083 W68672 CN479444 CR621508 BX432292 CR617149 AA804644 
    BQ710310 NM_001003789 AA492273 BQ710234 BC064551 AA435681 AI887990 AI150466 
    BC024281 BC020495 AW627731 BM922664 AI701071 AI624939 NM_007081 CD623641 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RABL2B    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4
    SP1:                              
    SP2:        -           -         


    ECgene alternative splicing isoforms for RABL2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RABL2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RABL2B Expression
    About this image


    See RABL2B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RABL2B

    SOURCE GeneReport for Unigene cluster: Hs.584862
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RABL2B gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves RABL2B1 RAB, member of RAS oncogene family-like 2B 72.42(n)
    76.36(a)
      426865  XM_424473.3  XP_424473.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    79(a)
    1 → many
    GL343765.1(55659-70125)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.255052 Xenopus laevis transcribed sequence with moderate similarity more 76.65(n)    BJ032133.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rabl21 RAB, member of RAS oncogene family-like 2 71.72(n)
    76.3(a)
      561568  NM_001044963.2  NP_001038428.1 
    worm
    (Caenorhabditis elegans)
    Secernentea glo-16
    Protein GLO-1
    23(a)
    1 → many
    X(9872910-9882214)
            Species with no ortholog for RABL2B

    ENSEMBL Gene Tree for RABL2B (if available)
    TreeFam Gene Tree for RABL2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RABL2B gene
    RAB9A2  RAB7A2  RAB9B2  RAB322  RAB7L12  RAB382  RABL2A2  
    18/66 SIMAP similar genes for RABL2B using alignment to 7 protein entries:     RBL2B_HUMAN (see all proteins) (see all similar genes):
    RABL2A    RAB4B    RAB11A    DKFZp686J07132    RAB41    RAB6A
    RAB8B    RAB30    RALA    RALB    RAB35    RAB11B
    RAB15    RANP1    RAB7A    RAB37    RAB3A    RAB9A

    RABL2B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing RABL2B
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RABL2B for disorders           About MalaCards
    OMIM gene information: 605413    OMIM disorders: --


    RABL2B for disorders           About GeneDecksing


    Export disorders for RABL2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RABL2B gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with RABL2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two novel human RAB genes with near identical sequence each map to a telomere-associated region: the subtelomeric region of 22q13.3 and the ancestral telomere band 2q13. (PubMed id 10444334)1, 2, 3 Wong A.C....McDermid H.E. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    5. Analysis of relative gene dosage and expression diffe rences of the paralogs RABL2A and RABL2B by Pyrosequencing. (PubMed id 20138207)1 Kramer M....Huse K. (2010)
    6. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    7. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    9. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1 Collins J.E.... Dunham I. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11158 HGNC: 9800 AceView: RABL2B Ensembl:ENSG00000079974 euGenes: HUgn11158
    ECgene: RABL2B H-InvDB: RABL2B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RABL2B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RABL2B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RABL2B gene:
    Search GeneIP for patents involving RABL2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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