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Aliases for RABL2A Gene

Aliases for RABL2A Gene

  • RAB, Member Of RAS Oncogene Family Like 2A 2 3 5

External Ids for RABL2A Gene

Previous GeneCards Identifiers for RABL2A Gene

  • GC02P111590
  • GC02P112305
  • GC02P114291
  • GC02P114479
  • GC02P114480
  • GC02P114101
  • GC02P114384
  • GC02P106705

Summaries for RABL2A Gene

Entrez Gene Summary for RABL2A Gene

  • This gene is a member of the RAB gene family which belongs to the RAS GTPase superfamily. The proteins in the family of RAS-related signaling molecules are small GTP-binding proteins that play important roles in the regulation of exocytotic and endocytotic pathways. This gene maps to the site of an ancestral telomere fusion event and may be a subtelomeric gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

GeneCards Summary for RABL2A Gene

RABL2A (RAB, Member Of RAS Oncogene Family Like 2A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RABL2B.

UniProtKB/Swiss-Prot for RABL2A Gene

  • Plays an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail.

Additional gene information for RABL2A Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RABL2A Gene

Genomics for RABL2A Gene

GeneHancer (GH) Regulatory Elements for RABL2A Gene

Promoters and enhancers for RABL2A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I113626 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 568 +0.0 45 1.5 HDAC1 ELF3 ATF1 RB1 ARID4B SIN3A DMAP1 BMI1 NCOA2 ZNF335 RABL2A RPL23AP7 PIR42427 DDX11L2
GH02I113582 Promoter/Enhancer 1.6 Ensembl ENCODE 24.7 -43.3 -43345 2.9 HDGF SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B WASH2P MIR1302-3 RABL2A RPS20P11 RNU6-744P ENSG00000233479 DDX11L2
GH02I112867 Enhancer 1.4 Ensembl ENCODE dbSUPER 16.7 -758.0 -757989 3.6 PKNOX1 CLOCK SMAD1 ATF1 FEZF1 ZNF2 ZNF121 ZNF213 KLF7 FOS IL1B WASH2P IL1A RABL2A IL37 RGPD8 CKAP2L ZC3H8 PIR40727 XIAPP3
GH02I113164 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -459.9 -459858 5.4 ATF1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 ETS1 YY1 PSD4 RABL2A PAX8-AS1 RGPD8 RNU6-1180P ZC3H6 IL1RN IL1B IL1A IL36B
GH02I113602 Enhancer 1 ENCODE 10.9 -23.3 -23256 2 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 DDX11L2 RPL23AP7 RABL2A ENSG00000227359 PAX8-AS1 PSD4 FOXD4L1 ENSG00000279267
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RABL2A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RABL2A gene promoter:

Genomic Locations for RABL2A Gene

Genomic Locations for RABL2A Gene
16,170 bases
Plus strand

Genomic View for RABL2A Gene

Genes around RABL2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RABL2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RABL2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RABL2A Gene

Proteins for RABL2A Gene

  • Protein details for RABL2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rab-like protein 2A
    Protein Accession:
    Secondary Accessions:
    • B7ZBD6
    • Q9NU37

    Protein attributes for RABL2A Gene

    228 amino acids
    Molecular mass:
    26115 Da
    Quaternary structure:
    • Interacts with IFT27, IFT81, IFT172, ATP6V1E1, HK1, LDHC, MAPRE1 and HSPA2.

    Alternative splice isoforms for RABL2A Gene


neXtProt entry for RABL2A Gene

Post-translational modifications for RABL2A Gene

No Post-translational modifications

No data available for DME Specific Peptides for RABL2A Gene

Domains & Families for RABL2A Gene

Gene Families for RABL2A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RABL2A Gene

Suggested Antigen Peptide Sequences for RABL2A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RABL2A: view

Function for RABL2A Gene

Molecular function for RABL2A Gene

GENATLAS Biochemistry:
RAB like gene 2A,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
Plays an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail.

Phenotypes From GWAS Catalog for RABL2A Gene

Gene Ontology (GO) - Molecular Function for RABL2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS,IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RABL2A: view
genes like me logo Genes that share phenotypes with RABL2A: view

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RABL2A Gene

Localization for RABL2A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RABL2A gene
Compartment Confidence
cytosol 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RABL2A Gene

Pathways & Interactions for RABL2A Gene

SuperPathways for RABL2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for RABL2A Gene


No data available for Pathways by source and SIGNOR curated interactions for RABL2A Gene

Drugs & Compounds for RABL2A Gene

No Compound Related Data Available

Transcripts for RABL2A Gene

Unigene Clusters for RABL2A Gene

RAB, member of RAS oncogene family-like 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RABL2A Gene

No ASD Table

Relevant External Links for RABL2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RABL2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RABL2A Gene

Protein differential expression in normal tissues from HIPED for RABL2A Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RABL2A Gene

Protein tissue co-expression partners for RABL2A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RABL2A Gene:


SOURCE GeneReport for Unigene cluster for RABL2A Gene:


mRNA Expression by UniProt/SwissProt for RABL2A Gene:

Tissue specificity: Expressed in the testis.
genes like me logo Genes that share expression patterns with RABL2A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RABL2A Gene

Orthologs for RABL2A Gene

This gene was present in the common ancestor of animals.

Orthologs for RABL2A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RABL2B 34
  • 99 (a)
  • 98.83 (n)
-- 34
  • 97 (a)
(Canis familiaris)
Mammalia -- 34
  • 88 (a)
(Rattus norvegicus)
Mammalia Rabl2a 33
  • 87.12 (n)
(Mus musculus)
Mammalia Rabl2 33 16 34
  • 86.52 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 84 (a)
(Bos Taurus)
Mammalia -- 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 47 (a)
(Gallus gallus)
Aves RABL2B 34
  • 75 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 80 (a)
(Danio rerio)
Actinopterygii rabl2 34
  • 73 (a)
fruit fly
(Drosophila melanogaster)
Insecta RabX6 34
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4950 34
  • 61 (a)
Species where no ortholog for RABL2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RABL2A Gene

Gene Tree for RABL2A (if available)
Gene Tree for RABL2A (if available)

Paralogs for RABL2A Gene

Variants for RABL2A Gene

Sequence variations from dbSNP and Humsavar for RABL2A Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000348867 -- 113,643,839(+) C/A downstream_transcript_variant
rs1000687582 -- 113,642,484(+) T/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1001245638 -- 113,631,331(+) A/G intron_variant
rs1001300608 -- 113,626,696(+) G/A/T upstream_transcript_variant
rs1001631114 -- 113,631,066(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RABL2A Gene

Variant ID Type Subtype PubMed ID
esv2759085 CNV gain+loss 17122850
esv3592016 CNV gain 21293372
esv3592027 CNV loss 21293372
nsv1001195 CNV gain 25217958
nsv508163 CNV deletion 20534489
nsv582714 CNV gain 21841781
nsv961495 CNV duplication 23825009

Variation tolerance for RABL2A Gene

Residual Variation Intolerance Score: 84.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.98; 68.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RABL2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RABL2A Gene

Disorders for RABL2A Gene

Additional Disease Information for RABL2A

No disorders were found for RABL2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RABL2A Gene

Publications for RABL2A Gene

  1. Two novel human RAB genes with near identical sequence each map to a telomere-associated region: the subtelomeric region of 22q13.3 and the ancestral telomere band 2q13. (PMID: 10444334) Wong AC … McDermid HE (Genomics 1999) 2 3 4 58
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for RABL2A Gene

Sources for RABL2A Gene

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