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Aliases for RABIF Gene

Aliases for RABIF Gene

  • RAB Interacting Factor 2 3 5
  • Rab-Interacting Factor 3 4
  • RASGRF3 3 4
  • MSS4 3 4
  • Ras-Specific Guanine-Releasing Factor 3 3
  • Mammalian Suppressor Of SEC4 3
  • RASGFR3 3

External Ids for RABIF Gene

Previous HGNC Symbols for RABIF Gene

  • RASGRF3

Previous GeneCards Identifiers for RABIF Gene

  • GC01M200532
  • GC01M198278
  • GC01M199314
  • GC01M200136
  • GC01M199579
  • GC01M201114
  • GC01M174013

Summaries for RABIF Gene

Entrez Gene Summary for RABIF Gene

  • This gene encodes a member of the SCE4/YPT1/RAB family of small GTP-binding proteins that are involved in the regulation of intracellular vesicular transport. This protein stimulates GTP-GDP exchange in SEC4, and to a lesser extent in YPT1 and RAB3A, and may play a general role in vesicular transport. [provided by RefSeq, Oct 2011]

GeneCards Summary for RABIF Gene

RABIF (RAB Interacting Factor) is a Protein Coding gene. Among its related pathways are RB in Cancer. GO annotations related to this gene include guanyl-nucleotide exchange factor activity.

UniProtKB/Swiss-Prot for RABIF Gene

  • Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1 and RAB3A, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport.

Gene Wiki entry for RABIF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RABIF Gene

Genomics for RABIF Gene

Regulatory Elements for RABIF Gene

Promoters for RABIF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RABIF on UCSC Golden Path with GeneCards custom track

Genomic Location for RABIF Gene

Chromosome:
1
Start:
202,878,282 bp from pter
End:
202,889,257 bp from pter
Size:
10,976 bases
Orientation:
Minus strand

Genomic View for RABIF Gene

Genes around RABIF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RABIF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RABIF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RABIF Gene

Proteins for RABIF Gene

  • Protein details for RABIF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47224-MSS4_HUMAN
    Recommended name:
    Guanine nucleotide exchange factor MSS4
    Protein Accession:
    P47224
    Secondary Accessions:
    • B2R4P4
    • Q92992

    Protein attributes for RABIF Gene

    Size:
    123 amino acids
    Molecular mass:
    13839 Da
    Quaternary structure:
    • Interacts with RAB8A.

    Three dimensional structures from OCA and Proteopedia for RABIF Gene

neXtProt entry for RABIF Gene

Proteomics data for RABIF Gene at MOPED

Post-translational modifications for RABIF Gene

No Post-translational modifications

Other Protein References for RABIF Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RABIF Gene

Domains & Families for RABIF Gene

Protein Domains for RABIF Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RABIF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47224

UniProtKB/Swiss-Prot:

MSS4_HUMAN :
  • Belongs to the DSS4/MSS4 family.
Family:
  • Belongs to the DSS4/MSS4 family.
genes like me logo Genes that share domains with RABIF: view

No data available for Gene Families for RABIF Gene

Function for RABIF Gene

Molecular function for RABIF Gene

GENATLAS Biochemistry:
guanine nucleotide releasing (exchange) factor,14kDa,specific for Sec4/Ypt/RAB family,RAS superfamily,of GTP binding proteins,involved in the regulation of intracellular vesicular transport,expressed in pancreatic cancer
UniProtKB/Swiss-Prot Function:
Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1 and RAB3A, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport.

Gene Ontology (GO) - Molecular Function for RABIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16541104
genes like me logo Genes that share ontologies with RABIF: view
genes like me logo Genes that share phenotypes with RABIF: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RABIF Gene

Localization for RABIF Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RABIF Gene COMPARTMENTS Subcellular localization image for RABIF gene
Compartment Confidence
cytoskeleton 3
cytosol 3
extracellular 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RABIF Gene

Pathways & Interactions for RABIF Gene

SuperPathways for RABIF Gene

Superpath Contained pathways
1 RB in Cancer
genes like me logo Genes that share pathways with RABIF: view

Pathways by source for RABIF Gene

1 BioSystems pathway for RABIF Gene

Gene Ontology (GO) - Biological Process for RABIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0061025 membrane fusion TAS 9441742
genes like me logo Genes that share ontologies with RABIF: view

No data available for SIGNOR curated interactions for RABIF Gene

Drugs & Compounds for RABIF Gene

No Compound Related Data Available

Transcripts for RABIF Gene

mRNA/cDNA for RABIF Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(103) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RABIF Gene

RAB interacting factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RABIF Gene

No ASD Table

Relevant External Links for RABIF Gene

GeneLoc Exon Structure for
RABIF
ECgene alternative splicing isoforms for
RABIF

Expression for RABIF Gene

mRNA expression in normal human tissues for RABIF Gene

Protein differential expression in normal tissues from HIPED for RABIF Gene

This gene is overexpressed in Bone (18.8) and Cervix (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RABIF Gene



SOURCE GeneReport for Unigene cluster for RABIF Gene Hs.90875

mRNA Expression by UniProt/SwissProt for RABIF Gene

P47224-MSS4_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with RABIF: view

Protein tissue co-expression partners for RABIF Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RABIF Gene

Orthologs for RABIF Gene

This gene was present in the common ancestor of animals.

Orthologs for RABIF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RABIF 35
  • 83.47 (n)
  • 86.99 (a)
RABIF 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RABIF 35
  • 93.22 (n)
  • 95.12 (a)
RABIF 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rabif 35
  • 91.87 (n)
  • 93.5 (a)
Rabif 16
Rabif 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RABIF 35
  • 99.73 (n)
  • 99.19 (a)
RABIF 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rabif 35
  • 89.43 (n)
  • 91.87 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia RABIF 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves RABIF 35
  • 73.71 (n)
  • 73.17 (a)
RABIF 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RABIF 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rabif 35
  • 67.54 (n)
  • 69.57 (a)
zebrafish
(Danio rerio)
Actinopterygii rabif 35
  • 69.91 (n)
  • 73.45 (a)
wufc54e04 35
rabif 36
  • 49 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008798 35
  • 48.41 (n)
  • 42.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7787 35
  • 54.09 (n)
  • 43.4 (a)
CG7787 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mdt-9 36
  • 26 (a)
OneToMany
ZK970.8 36
  • 27 (a)
OneToMany
Species with no ortholog for RABIF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RABIF Gene

ENSEMBL:
Gene Tree for RABIF (if available)
TreeFam:
Gene Tree for RABIF (if available)

Paralogs for RABIF Gene

No data available for Paralogs for RABIF Gene

Variants for RABIF Gene

Sequence variations from dbSNP and Humsavar for RABIF Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs8884 -- 202,879,163(-) aaTAT(A/G)TAGCG utr-variant-3-prime
rs1131905 -- 202,880,642(-) CTAGA(A/G)GAGCA utr-variant-3-prime
rs1131906 -- 202,880,595(-) AGATG(C/T)TTATG utr-variant-3-prime
rs1131907 -- 202,879,349(-) gaaca(A/G)aatta utr-variant-3-prime
rs1140707 -- 202,880,467(-) GCATT(C/T)TCAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RABIF Gene

Variant ID Type Subtype PubMed ID
nsv832359 CNV Loss 17160897

Variation tolerance for RABIF Gene

Residual Variation Intolerance Score: 67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RABIF Gene

HapMap Linkage Disequilibrium report
RABIF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RABIF Gene

Disorders for RABIF Gene

Relevant External Links for RABIF

Genetic Association Database (GAD)
RABIF
Human Genome Epidemiology (HuGE) Navigator
RABIF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RABIF

No disorders were found for RABIF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RABIF Gene

Publications for RABIF Gene

  1. Cloning of novel transcripts of the human guanine-nucleotide-exchange factor Mss4: in situ chromosomal mapping and expression in pancreatic cancer. (PMID: 9441742) Mueller-Pillasch F. … Gress T.M. (Genomics 1997) 2 3 4 23 67
  2. Cloning, Zn2+ binding, and structural characterization of the guanine nucleotide exchange factor human Mss4. (PMID: 7619808) Yu H. … Schreiber S.L. (Biochemistry 1995) 2 3 23
  3. Structure of guanine-nucleotide-exchange factor human Mss4 and identification of its Rab-interacting surface. (PMID: 7651540) Yu H. … Schreiber S.L. (Nature 1995) 3 23
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for RABIF Gene

Sources for RABIF Gene

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