RABIF Gene
protein-coding GIFtS: 50
GCID: GC01M202848
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RAB interacting factor
(Previous symbol: RASGRF3)
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Aliases
for RABIF gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RAB Interacting Factor1 2 | | Mss41 | | RASGRF31 2 3 | | Guanine Nucleotide Exchange Factor MSS42 | | MSS42 3 5 | | Mammalian Suppressor Of SEC42 | | Rab-Interacting Factor2 3 | | Ras-Specific Guanine-Releasing Factor 32 | | RASGFR32 5 | | |
Export aliases for RABIF gene to outside databasesPrevious GC identifers: GC01M200532 GC01M198278 GC01M199314 GC01M200136 GC01M199579 GC01M201114 GC01M174013 |
Summaries
for RABIF gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RABIF:
This gene encodes a member of the SCE4/YPT1/RAB family of small GTP-binding proteins that are involved in theregulation of intracellular vesicular transport. This protein stimulates GTP-GDP exchange in SEC4, and to a lesserextent in YPT1 and RAB3A, and may play a general role in vesicular transport. (provided by RefSeq, Oct 2011)
UniProtKB/Swiss-Prot: MSS4_HUMAN, P47224Function: Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDPrelease from both YPT1 and RAB3A, but is less active on these proteins than on the SEC4 protein. Might play a generalrole in vesicular transport
Gene Wiki entry for RABIF
|
Genomic Views
for RABIF gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RABIF gene promoter:
AML1a FOXD3 HNF-3beta C/EBPalpha CHOP-10 POU2F1 E2F POU2F1a ZID
Other transcription factors
Search SABiosciences Chromatin IP Primers for RABIF
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RABIF |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.1RABIF Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M202848: view genomic region
(about GC identifiers)
Start:
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202,848,085 bp from pter |
End:
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202,858,263 bp from pter |
Size:
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10,179 bases |
Orientation:
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minus strand |
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Proteins
for RABIF gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MSS4_HUMAN, P47224 (See
protein sequence)Recommended Name: Guanine nucleotide exchange factor MSS4 Size: 123 amino acids; 13839 Da
Subunit: Interacts with RAB8A
2 PDB 3D structures from  and Proteopedia  for RABIF:1FWQ (3D)
2FU5 (3D)
Secondary accessions: B2R4P4 Q92992Explore the universe of human proteins at neXtProt for RABIF: NX_P47224
RABIF Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002862.2
ENSEMBL proteins: ENSP00000356231
Human Recombinant Protein Products:
RABIF Antibody Products:
Assay Products for RABIF: |
Protein
Domains /
Families
for RABIF gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RABIF for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P47224ProtoNet protein and cluster: P47224 1 Blocks protein family: IPB007515 Mss4
UniProtKB/Swiss-Prot: MSS4_HUMAN, P47224Similarity: Belongs to the DSS4/MSS4 family |
Function
for RABIF gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MSS4_HUMAN, P47224Function: Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDPrelease from both YPT1 and RAB3A, but is less active on these proteins than on the SEC4 protein. Might play a generalrole in vesicular transport Genatlas biochemistry entry for RABIF:guanine nucleotide releasing (exchange) factor,14kDa,specific for Sec4/Ypt/RAB family,RAS superfamily,of GTP bindingproteins,involved in the regulation of intracellular vesicular transport,expressed in pancreatic cancer
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RABIF
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RABIF |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
RABIF for ontologies About GeneDecksing
|
Pathways & Interactions
for RABIF gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RABIF
STRING Interaction
Network Preview (showing 5 interactants - click image to see 19)
5/21 Interacting proteins for RABIF (P472242, 3 ENSP000003562314) via UniProtKB, MINT, STRING, and/or I2D (see all 21)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
RABIF for ontologies About GeneDecksing
|
Drugs & Compounds
for RABIF gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RABIF
Search CenterWatch for drugs/clinical trials and news about RABIF / MSS4
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Transcripts
for RABIF gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RABIF gene: NM_002871.4 Unigene Cluster for RABIF: RAB interacting factor Hs.90875 [show with all ESTs]Unigene Representative Sequence: NM_0028711 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000367262(uc001gyl.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RABIF (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RABIF
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RABIF (NM_002871) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RABIF | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RABIF |
Additional cDNA sequence: AK223538.1 AK311900.1 BC018488.1 BC037392.1 BT007133.1 S78873.1 U74324.1 4 DOTS entries: DT.454350 DT.100748395 DT.87011738 DT.40265072 24/103 AceView cDNA sequences (see all 103): CA429153 U74324 CR593497 BQ219822 AW511523 BU502612 F04513 BQ232014 BU176130 BU196764 BM913014 BM915651 BQ935588 AI911231 CA447173 F04594 BE395980 AW005793 BG180289 NM_002871 AI419298 F08368 N36134 BT007133
GeneLoc Exon Structure
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Expression
for RABIF gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RABIF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTAACTGAG
About this image
See RABIF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RABIF
SOURCE GeneReport for Unigene cluster: Hs.90875
UniProtKB/Swiss-Prot: MSS4_HUMAN, P47224Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for RABIF
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RABIF
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RABIF | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RABIF | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RABIF | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RABIF |
Orthologs
for RABIF gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for RABIF gene from 7/20 species (see all 20) About this table
ENSEMBL Gene Tree for RABIF (if available)
TreeFam Gene Tree for RABIF (if available) |
Paralogs
for RABIF gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for RABIF gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for RABIF (202848085 - 202858263 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RABIF: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RABIF |
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Disorders
/ Diseases
for RABIF gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RABIF for disorders About GeneDecksing
OMIM gene information: 603417
OMIM disorders: --
4  diseases for RABIF: About MalaCardsessential hypertension hypertension pancreatic cancer pancreatitis
Human Genome Epidemiology (HuGE) Navigator: RABIF (1 document)
Export disorders for RABIF gene to outside databases
|
Publications
for RABIF gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RABIF gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with RABIF) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of novel transcripts of the human guanine-nucleotide-exchange factor Mss4: in situ chromosomal mapping and expression in pancreatic cancer. (PubMed id 9441742)1, 2, 3, 9 Mueller-Pillasch F.... Gress T.M. (1997)
- Cloning, Zn2+ binding, and structural characterization of the guanine nucleotide exchange factor human Mss4. (PubMed id 7619808)1, 2, 3, 9 Yu H. and Schreiber S.L. (1995)
- Structure of guanine-nucleotide-exchange factor human Mss4 and identification of its Rab-interacting surface. (PubMed id 7651540)1, 2, 9 Yu H. and Schreiber S.L. (1995)
- Nucleotide exchange via local protein unfolding--stru cture of Rab8 in complex with MSS4. (PubMed id 16541104)1, 2 Itzen A....Rak A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Mss4 protein is a regulator of stress response and apo ptosis. (PubMed id 22495352)1 Walter B.M....Wixler V. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- Follow-up of a major linkage peak on chromosome 1 rev eals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1 Ehret G.B....Chakravarti A. (2009)
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External Searches for RABIF gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing RABIF gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RABIF gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RABIF gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RABIF | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for RABIF gene:
Search GeneIP for patents involving RABIF
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RABIF gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
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 | | | RABIF Proteins, Antibodies, CLIAs, and ELISAs |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RABIF |
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