Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RABGGTB Gene

Aliases for RABGGTB Gene

  • Rab Geranylgeranyltransferase Beta Subunit 2 3 5
  • Type II Protein Geranyl-Geranyltransferase Subunit Beta 3 4
  • Rab GG Transferase Beta 3 4
  • Rab GGTase Beta 3 4
  • GGTase-II-Beta 3 4
  • EC 2.5.1.60 4 61
  • GGTB 3 4
  • Geranylgeranyl Transferase Type II Subunit Beta 4
  • Geranylgeranyl Transferase Type-2 Subunit Beta 3
  • Rab Geranyl-Geranyltransferase Subunit Beta 4
  • Rab Geranylgeranyltransferase Subunit Beta 4

External Ids for RABGGTB Gene

Previous GeneCards Identifiers for RABGGTB Gene

  • GC01P076371
  • GC01P075186
  • GC01P075667
  • GC01P075674
  • GC01P075963
  • GC01P076024
  • GC01P076251
  • GC01P074381

Summaries for RABGGTB Gene

Entrez Gene Summary for RABGGTB Gene

  • This gene encodes the beta-subunit of the enzyme Rab geranylgeranyl-transferase (RabGGTase), which belongs to the protein prenyltransferase family. RabGGTase catalyzes the post-translational addition of geranylgeranyl groups to C-terminal cysteine residues of Rab GTPases. Three small nucleolar RNA genes are present in the intronic regions of this gene. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 3. [provided by RefSeq, Jan 2013]

GeneCards Summary for RABGGTB Gene

RABGGTB (Rab Geranylgeranyltransferase Beta Subunit) is a Protein Coding gene. Among its related pathways are Signaling events mediated by PRL and Gene Expression. GO annotations related to this gene include Rab GTPase binding and Rab geranylgeranyltransferase activity. An important paralog of this gene is PGGT1B.

UniProtKB/Swiss-Prot for RABGGTB Gene

  • Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RABGGTB Gene

Genomics for RABGGTB Gene

Regulatory Elements for RABGGTB Gene

Enhancers for RABGGTB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G075722 1.4 Ensembl ENCODE 18.6 -61.1 -61083 6.0 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ACADM RABGGTB SNORD45A SNORD45C MSH4 DLSTP1 PIR54256
GH01G075784 1.5 FANTOM5 ENCODE 9.1 +1.8 1751 7.7 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 ZNF766 MSH4 RABGGTB ACADM SNORD45A GC01P075797
GH01G075765 0.9 Ensembl ENCODE 7.2 -20.3 -20303 1.6 JUN CHD1 CHD7 JUND ATF3 POLR2A SMARCA4 HDAC2 POU5F1 FOS MSH4 ACADM RABGGTB DLSTP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RABGGTB on UCSC Golden Path with GeneCards custom track

Promoters for RABGGTB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000008612 606 3201 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 KLF13 PAF1

Genomic Location for RABGGTB Gene

Chromosome:
1
Start:
75,786,194 bp from pter
End:
75,795,090 bp from pter
Size:
8,897 bases
Orientation:
Plus strand

Genomic View for RABGGTB Gene

Genes around RABGGTB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RABGGTB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RABGGTB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RABGGTB Gene

Proteins for RABGGTB Gene

  • Protein details for RABGGTB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53611-PGTB2_HUMAN
    Recommended name:
    Geranylgeranyl transferase type-2 subunit beta
    Protein Accession:
    P53611
    Secondary Accessions:
    • Q92697

    Protein attributes for RABGGTB Gene

    Size:
    331 amino acids
    Molecular mass:
    36924 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp. Interaction of RABGGTB with prenylated PTP4A2 precludes its association with RABGGTA and inhibits enzyme activity.

neXtProt entry for RABGGTB Gene

Selected DME Specific Peptides for RABGGTB Gene

P53611:
  • DVCYSWWVL
  • GWWLCERQLP
  • TLSAVQIL
  • NFDGGFG
  • ESHAGQI
  • ETGGFADRPGD

Post-translational modifications for RABGGTB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RABGGTB Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for RABGGTB Gene

Protein Domains for RABGGTB Gene

Suggested Antigen Peptide Sequences for RABGGTB Gene

Graphical View of Domain Structure for InterPro Entry

P53611

UniProtKB/Swiss-Prot:

PGTB2_HUMAN :
  • Belongs to the protein prenyltransferase subunit beta family.
Family:
  • Belongs to the protein prenyltransferase subunit beta family.
genes like me logo Genes that share domains with RABGGTB: view

No data available for Gene Families for RABGGTB Gene

Function for RABGGTB Gene

Molecular function for RABGGTB Gene

GENATLAS Biochemistry:
Rab geranyl-geranyltransferase B,type II,beta subunit
UniProtKB/Swiss-Prot CatalyticActivity:
Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
The enzymatic reaction requires the aid of a Rab escort protein (also called component A).
UniProtKB/Swiss-Prot Function:
Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

Enzyme Numbers (IUBMB) for RABGGTB Gene

Gene Ontology (GO) - Molecular Function for RABGGTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004659 prenyltransferase activity IEA --
GO:0004663 Rab geranylgeranyltransferase activity ISS --
GO:0005515 protein binding IPI 12620389
GO:0008270 zinc ion binding ISS --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with RABGGTB: view
genes like me logo Genes that share phenotypes with RABGGTB: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RABGGTB

miRNA for RABGGTB Gene

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RABGGTB Gene

Localization for RABGGTB Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RABGGTB gene
Compartment Confidence
plasma membrane 5
cytosol 5
cytoskeleton 2
peroxisome 2
extracellular 1
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RABGGTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005968 Rab-protein geranylgeranyltransferase complex ISS,IBA --
genes like me logo Genes that share ontologies with RABGGTB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RABGGTB Gene

Pathways & Interactions for RABGGTB Gene

genes like me logo Genes that share pathways with RABGGTB: view

Pathways by source for RABGGTB Gene

Gene Ontology (GO) - Biological Process for RABGGTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process NAS 8380507
GO:0007601 visual perception TAS 8380507
GO:0018344 protein geranylgeranylation ISS,IBA --
GO:0042981 regulation of apoptotic process TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with RABGGTB: view

No data available for SIGNOR curated interactions for RABGGTB Gene

Drugs & Compounds for RABGGTB Gene

(3) Drugs for RABGGTB Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
farnesyl diphosphate Experimental Pharma Antagonist, Target 0
GERANYLGERANYL DIPHOSPHATE Experimental Pharma Feedback inhibition, Inhibitor, Target 0
N-Formylmethionine Experimental Pharma Target 0

(2) Additional Compounds for RABGGTB Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Geranylgeranyl-PP
  • 2-trans,6-trans,10-trans-Geranylgeranyl diphosphate
  • 3,7,11,15-Tetramethyl-2,6,10,14-hexadecatetraenyl diphosphate
  • All-trans-geranyl-geranyl-pp
  • Geranylgeranyl-diphosphate
  • Geranylgeranyl-PP
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with RABGGTB: view

Transcripts for RABGGTB Gene

Unigene Clusters for RABGGTB Gene

Rab geranylgeranyltransferase, beta subunit:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RABGGTB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - -
SP5: -
SP6: - - - - - -
SP7: - - - - - -
SP8: - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - -
SP12: - -
SP13: - - - - - - - - -
SP14: - -
SP15: -
SP16: - - - -
SP17: -
SP18:
SP19: - - - - - - - - - - -
SP20:
SP21: - - - -
SP22: -
SP23:

ExUns: 10c · 10d · 10e ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13a · 13b · 13c · 13d
SP1: - - -
SP2: - - -
SP3: - -
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - -
SP14:
SP15: - - - -
SP16:
SP17: - -
SP18: - - - -
SP19:
SP20:
SP21:
SP22:
SP23:

Relevant External Links for RABGGTB Gene

GeneLoc Exon Structure for
RABGGTB
ECgene alternative splicing isoforms for
RABGGTB

Expression for RABGGTB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RABGGTB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RABGGTB Gene

This gene is overexpressed in Bone (43.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RABGGTB Gene



Protein tissue co-expression partners for RABGGTB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RABGGTB Gene:

RABGGTB

SOURCE GeneReport for Unigene cluster for RABGGTB Gene:

Hs.78948

Evidence on tissue expression from TISSUES for RABGGTB Gene

  • Nervous system(4.6)
  • Muscle(4.4)
  • Liver(2.4)
  • Kidney(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with RABGGTB: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RABGGTB Gene

Orthologs for RABGGTB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RABGGTB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RABGGTB 34 35
  • 99.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RABGGTB 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RABGGTB 34 35
  • 92.04 (n)
cow
(Bos Taurus)
Mammalia RABGGTB 34 35
  • 91.34 (n)
oppossum
(Monodelphis domestica)
Mammalia RABGGTB 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rabggtb 34 16 35
  • 86.61 (n)
rat
(Rattus norvegicus)
Mammalia Rabggtb 34
  • 84.79 (n)
chicken
(Gallus gallus)
Aves RABGGTB 34 35
  • 80.46 (n)
lizard
(Anolis carolinensis)
Reptilia RABGGTB 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rabggtb 34
  • 79.76 (n)
Str.4848 34
zebrafish
(Danio rerio)
Actinopterygii rabggtb 34 35
  • 75.53 (n)
fruit fly
(Drosophila melanogaster)
Insecta bgrggt-II 36
  • 64 (a)
betaggt-II 34 35
  • 58.14 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013277 34
  • 59.17 (n)
worm
(Caenorhabditis elegans)
Secernentea ggtb-1 34 35
  • 57.25 (n)
B0280.1a 36
  • 55 (a)
B0280.1b 36
  • 55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BET2 34 35 37
  • 56.06 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E04797g 34
  • 53.62 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL268W 34
  • 52.26 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RGTB1 34
  • 59.04 (n)
rice
(Oryza sativa)
Liliopsida Os08g0512300 34
  • 59.59 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 65 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ptb1 34
  • 55.12 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07509 34
  • 53.16 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3098 34
Species where no ortholog for RABGGTB was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RABGGTB Gene

ENSEMBL:
Gene Tree for RABGGTB (if available)
TreeFam:
Gene Tree for RABGGTB (if available)

Paralogs for RABGGTB Gene

Paralogs for RABGGTB Gene

(1) SIMAP similar genes for RABGGTB Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for RABGGTB Gene

genes like me logo Genes that share paralogs with RABGGTB: view

Variants for RABGGTB Gene

Sequence variations from dbSNP and Humsavar for RABGGTB Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000387919 -- 75,793,442(+) CGGGT(A/G)GAGAA intron-variant
rs1000398920 -- 75,793,047(+) GACCT(C/T)GTGAT intron-variant
rs1000443143 -- 75,785,854(+) TATCG(C/G)TCAGC upstream-variant-2KB
rs1000689542 -- 75,792,344(+) TAGAA(C/T)CTTGA intron-variant
rs1000794329 -- 75,791,414(+) TGATC(C/T)GCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RABGGTB Gene

Variant ID Type Subtype PubMed ID
nsv519329 CNV gain 19592680

Variation tolerance for RABGGTB Gene

Residual Variation Intolerance Score: 20.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RABGGTB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RABGGTB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RABGGTB Gene

Disorders for RABGGTB Gene

Relevant External Links for RABGGTB

Genetic Association Database (GAD)
RABGGTB
Human Genome Epidemiology (HuGE) Navigator
RABGGTB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RABGGTB

No disorders were found for RABGGTB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RABGGTB Gene

Publications for RABGGTB Gene

  1. Characterization of the interaction of the monomeric GTP-binding protein Rab3a with geranylgeranyl transferase II. (PMID: 8706741) Johannes L. … Darchen F. (Eur. J. Biochem. 1996) 2 3 4 64
  2. cDNA cloning and chromosomal localization of the genes encoding the alpha- and beta-subunits of human Rab geranylgeranyl transferase: the 3' end of the alpha-subunit gene overlaps with the transglutaminase 1 gene promoter. (PMID: 8954794) van Bokhoven H. … Seabra M.C. (Genomics 1996) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Interaction of farnesylated PRL-2, a protein-tyrosine phosphatase, with the beta-subunit of geranylgeranyltransferase II. (PMID: 11447212) Si X. … Pallen C.J. (J. Biol. Chem. 2001) 3 4 64

Products for RABGGTB Gene

Sources for RABGGTB Gene

Content
Loading form....