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Aliases for RABGGTB Gene

Aliases for RABGGTB Gene

  • Rab Geranylgeranyltransferase, Beta Subunit 2 3
  • Type II Protein Geranyl-Geranyltransferase Subunit Beta 3 4
  • Rab GG Transferase Beta 3 4
  • Rab GGTase Beta 3 4
  • GGTase-II-Beta 3 4
  • EC 2.5.1.60 4 64
  • GGTB 3 4
  • Geranylgeranyl Transferase Type II Subunit Beta 4
  • Geranylgeranyl Transferase Type-2 Subunit Beta 3
  • Rab Geranyl-Geranyltransferase Subunit Beta 4
  • Rab Geranylgeranyltransferase Subunit Beta 4

External Ids for RABGGTB Gene

Summaries for RABGGTB Gene

Entrez Gene Summary for RABGGTB Gene

  • This gene encodes the beta-subunit of the enzyme Rab geranylgeranyl-transferase (RabGGTase), which belongs to the protein prenyltransferase family. RabGGTase catalyzes the post-translational addition of geranylgeranyl groups to C-terminal cysteine residues of Rab GTPases. Three small nucleolar RNA genes are present in the intronic regions of this gene. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 3. [provided by RefSeq, Jan 2013]

GeneCards Summary for RABGGTB Gene

RABGGTB (Rab Geranylgeranyltransferase, Beta Subunit) is a Protein Coding gene. Diseases associated with RABGGTB include choroideremia. Among its related pathways are Signaling events mediated by PRL. GO annotations related to this gene include Rab geranylgeranyltransferase activity. An important paralog of this gene is PGGT1B.

UniProtKB/Swiss-Prot for RABGGTB Gene

  • Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RABGGTB Gene

Genomics for RABGGTB Gene

Genomic Location for RABGGTB Gene

Start:
75,786,194 bp from pter
End:
75,795,090 bp from pter
Size:
8,897 bases
Orientation:
Plus strand

Genomic View for RABGGTB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RABGGTB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RABGGTB Gene

Regulatory Elements for RABGGTB Gene

Proteins for RABGGTB Gene

  • Protein details for RABGGTB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53611-PGTB2_HUMAN
    Recommended name:
    Geranylgeranyl transferase type-2 subunit beta
    Protein Accession:
    P53611
    Secondary Accessions:
    • Q92697

    Protein attributes for RABGGTB Gene

    Size:
    331 amino acids
    Molecular mass:
    36924 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp. Interaction of RABGGTB with prenylated PTP4A2 precludes its association with RABGGTA and inhibits enzyme activity.

neXtProt entry for RABGGTB Gene

Proteomics data for RABGGTB Gene at MOPED

Selected DME Specific Peptides for RABGGTB Gene

Post-translational modifications for RABGGTB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RABGGTB Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for RABGGTB Gene

Protein Domains for RABGGTB Gene

UniProtKB/Swiss-Prot:

PGTB2_HUMAN
Family:
  • Belongs to the protein prenyltransferase subunit beta family.:
    • P53611
Similarity:
  • Contains 6 PFTB repeats.:
    • P53611
genes like me logo Genes that share domains with RABGGTB: view

No data available for Gene Families for RABGGTB Gene

Function for RABGGTB Gene

Molecular function for RABGGTB Gene

GENATLAS Biochemistry: Rab geranyl-geranyltransferase B,type II,beta subunit
UniProtKB/Swiss-Prot CatalyticActivity: Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate
UniProtKB/Swiss-Prot EnzymeRegulation: The enzymatic reaction requires the aid of a Rab escort protein (also called component A)
UniProtKB/Swiss-Prot Function: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A

Enzyme Numbers (IUBMB) for RABGGTB Gene

Gene Ontology (GO) - Molecular Function for RABGGTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004663 Rab geranylgeranyltransferase activity ISS --
GO:0005515 protein binding IPI 12620389
GO:0008270 zinc ion binding ISS --
GO:0017137 Rab GTPase binding ISS --
genes like me logo Genes that share ontologies with RABGGTB: view

Phenotypes for RABGGTB Gene

GenomeRNAi human phenotypes for RABGGTB:
genes like me logo Genes that share phenotypes with RABGGTB: view

miRNA for RABGGTB Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RABGGTB Gene

Localization for RABGGTB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RABGGTB Gene COMPARTMENTS Subcellular localization image for RABGGTB gene
Compartment Confidence
cytoskeleton 2
peroxisome 2
cytosol 1
extracellular 1
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RABGGTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005968 Rab-protein geranylgeranyltransferase complex ISS --
genes like me logo Genes that share ontologies with RABGGTB: view

Pathways for RABGGTB Gene

genes like me logo Genes that share pathways with RABGGTB: view

Pathways by source for RABGGTB Gene

1 BioSystems pathway for RABGGTB Gene

Gene Ontology (GO) - Biological Process for RABGGTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process NAS 8380507
GO:0007601 visual perception TAS 8380507
GO:0018344 protein geranylgeranylation ISS --
genes like me logo Genes that share ontologies with RABGGTB: view

Compounds for RABGGTB Gene

(4) Drugbank Compounds for RABGGTB Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
FARNESYL
target
FARNESYL DIPHOSPHATE
target
GERANYLGERANYL DIPHOSPHATE
target
N-Formylmethionine
target
genes like me logo Genes that share compounds with RABGGTB: view

Transcripts for RABGGTB Gene

Unigene Clusters for RABGGTB Gene

Rab geranylgeranyltransferase, beta subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RABGGTB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - -
SP5: -
SP6: - - - - - -
SP7: - - - - - -
SP8: - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - -
SP12: - -
SP13: - - - - - - - - -
SP14: - -
SP15: -
SP16: - - - -
SP17: -
SP18:
SP19: - - - - - - - - - - -
SP20:
SP21: - - - -
SP22: -
SP23:

ExUns: 10c · 10d · 10e ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13a · 13b · 13c · 13d
SP1: - - -
SP2: - - -
SP3: - -
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - -
SP14:
SP15: - - - -
SP16:
SP17: - -
SP18: - - - -
SP19:
SP20:
SP21:
SP22:
SP23:

Relevant External Links for RABGGTB Gene

GeneLoc Exon Structure for
RABGGTB
ECgene alternative splicing isoforms for
RABGGTB

Expression for RABGGTB Gene

mRNA expression in normal human tissues for RABGGTB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RABGGTB Gene

SOURCE GeneReport for Unigene cluster for RABGGTB Gene Hs.78948

genes like me logo Genes that share expressions with RABGGTB: view

Orthologs for RABGGTB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RABGGTB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RABGGTB 36
  • 99.66 (n)
  • 100 (a)
RABGGTB 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RABGGTB 36
  • 91.34 (n)
  • 97.89 (a)
RABGGTB 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RABGGTB 36
  • 92.04 (n)
  • 98.19 (a)
RABGGTB 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rabggtb 36
  • 86.61 (n)
  • 96.07 (a)
Rabggtb 16
Rabggtb 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RABGGTB 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RABGGTB 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rabggtb 36
  • 84.79 (n)
  • 95.77 (a)
chicken
(Gallus gallus)
Aves RABGGTB 36
  • 80.46 (n)
  • 91.24 (a)
RABGGTB 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RABGGTB 37
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rabggtb 36
  • 79.76 (n)
  • 90.63 (a)
Str.4848 36
zebrafish
(Danio rerio)
Actinopterygii rabggtb 36
  • 75.53 (n)
  • 87.92 (a)
rabggtb 37
  • 88 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013277 36
  • 59.17 (n)
  • 64.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta betaggt-II 36
  • 58.14 (n)
  • 65.05 (a)
betaggt-II 37
  • 58 (a)
OneToOne
bgrggt-II 38
  • 64 (a)
worm
(Caenorhabditis elegans)
Secernentea ggtb-1 36
  • 57.25 (n)
  • 54.97 (a)
ggtb-1 37
  • 53 (a)
ManyToMany
B0280.1a 38
  • 55 (a)
B0280.1b 38
  • 55 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL268W 36
  • 52.26 (n)
  • 51.94 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BET2 36
  • 56.06 (n)
  • 53.05 (a)
BET2 37
  • 50 (a)
OneToMany
BET2 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E04797g 36
  • 53.62 (n)
  • 49.01 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RGTB1 36
  • 59.04 (n)
  • 58.5 (a)
rice
(Oryza sativa)
Liliopsida Os08g0512300 36
  • 59.59 (n)
  • 55.95 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07509 36
  • 53.16 (n)
  • 51.63 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ptb1 36
  • 55.12 (n)
  • 47.25 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3098 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 65 (a)
OneToOne
Species with no ortholog for RABGGTB:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RABGGTB Gene

ENSEMBL:
Gene Tree for RABGGTB (if available)
TreeFam:
Gene Tree for RABGGTB (if available)

Paralogs for RABGGTB Gene

Paralogs for RABGGTB Gene

Selected SIMAP similar genes for RABGGTB Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for RABGGTB Gene

genes like me logo Genes that share paralogs with RABGGTB: view

Variants for RABGGTB Gene

Sequence variations from dbSNP and Humsavar for RABGGTB Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs12703 -- 75,792,207(+) CTGGC(A/T)ATTAC reference, synonymous-codon, nc-transcript-variant
rs1146630 -- 75,784,388(-) acgtg(C/T)aggtt upstream-variant-2KB
rs1146631 -- 75,784,951(-) aaagg(C/G)ggttc upstream-variant-2KB
rs1146637 -- 75,790,933(-) GGGCA(C/T)TGTGG intron-variant
rs1146639 -- 75,792,833(-) AATAC(A/G)AGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RABGGTB Gene

Variant ID Type Subtype PubMed ID
nsv519329 CNV Gain 19592680

Relevant External Links for RABGGTB Gene

HapMap Linkage Disequilibrium report
RABGGTB

Disorders for RABGGTB Gene

(1) MalaCards Diseases for RABGGTB Gene

Search for RABGGTB Gene in MalaCards »

Relevant External Links for RABGGTB

Genetic Association Database (GAD)
RABGGTB
Human Genome Epidemiology (HuGE) Navigator
RABGGTB
genes like me logo Genes that share disorders with RABGGTB: view

No data available for UniProtKB/Swiss-Prot for RABGGTB Gene

Publications for RABGGTB Gene

  1. Characterization of the interaction of the monomeric GTP-binding protein Rab3a with geranylgeranyl transferase II. (PMID: 8706741) Johannes L. … Darchen F. (Eur. J. Biochem. 1996) 2 3 4
  2. cDNA cloning and chromosomal localization of the genes encoding the alpha- and beta-subunits of human Rab geranylgeranyl transferase: the 3' end of the alpha-subunit gene overlaps with the transglutaminase 1 gene promoter. (PMID: 8954794) van Bokhoven H. … Seabra M.C. (Genomics 1996) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. (PMID: 7991565) Farnsworth C.C. … Glomset J.A. (Proc. Natl. Acad. Sci. U.S.A. 1994) 3 4
  5. Interaction of farnesylated PRL-2, a protein-tyrosine phosphatase, with the beta-subunit of geranylgeranyltransferase II. (PMID: 11447212) Si X. … Pallen C.J. (J. Biol. Chem. 2001) 3 4

Products for RABGGTB Gene

Sources for RABGGTB Gene

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