Aliases for RABGGTB Gene
External Ids for RABGGTB Gene
Previous GeneCards Identifiers for RABGGTB Gene
This gene encodes the beta-subunit of the enzyme Rab geranylgeranyl-transferase (RabGGTase), which belongs to the protein prenyltransferase family. RabGGTase catalyzes the post-translational addition of geranylgeranyl groups to C-terminal cysteine residues of Rab GTPases. Three small nucleolar RNA genes are present in the intronic regions of this gene. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 3. [provided by RefSeq, Jan 2013]
GeneCards Summary for RABGGTB Gene
RABGGTB (Rab Geranylgeranyltransferase Beta Subunit) is a Protein Coding gene. Among its related pathways are Signaling events mediated by PRL and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include Rab GTPase binding and Rab geranylgeranyltransferase activity. An important paralog of this gene is PGGT1B.
UniProtKB/Swiss-Prot for RABGGTB Gene
Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.