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RABGGTA Gene

protein-coding   GIFtS: 58
GCID: GC14M024734

Rab Geranylgeranyltransferase, Alpha Subunit

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rab Geranylgeranyltransferase, Alpha Subunit1 2     Rab GGTase Alpha2 3
Protein Prenyltransferase Alpha Subunit Repeat Containing 31 2     EC 2.5.1.603 8
Geranylgeranyl Transferase Type II Subunit Alpha2 3     PTAR32
Rab Geranyl-Geranyltransferase Subunit Alpha2 3     Geranylgeranyl Transferase Type-2 Subunit Alpha2
Rab GG Transferase Alpha2 3     Rab Geranylgeranyltransferase Subunit Alpha3

External Ids:    HGNC: 97951   Entrez Gene: 58752   Ensembl: ENSG000001009497   OMIM: 6019055   UniProtKB: Q926963   

Export aliases for RABGGTA gene to outside databases

Previous GC identifers: GC14M022107 GC14M018522 GC14M022724 GC14M023804 GC14M004849


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RABGGTA Gene:
RABGGTA (Rab geranylgeranyltransferase, alpha subunit) is a protein-coding gene. Diseases associated with RABGGTA include choroideremia, and hermansky-pudlak syndrome. GO annotations related to this gene include Rab geranylgeranyltransferase activity.

UniProtKB/Swiss-Prot: PGTA_HUMAN, Q92696
Function: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of
Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RABGGTA gene promoter:
         Sp1   STAT3   CUTL1   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRABGGTA promoter sequence
   Search Chromatin IP Primers for RABGGTA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RABGGTA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q11.2

RABGGTA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RABGGTA gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M024734:  view genomic region     (about GC identifiers)

Start:
24,734,744 bp from pter      End:
24,740,945 bp from pter
Size:
6,202 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PGTA_HUMAN, Q92696 (See protein sequence)
Recommended Name: Geranylgeranyl transferase type-2 subunit alpha  
Size: 567 amino acids; 65072 Da
Subunit: Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the
catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT)
interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl
pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp
Secondary accessions: A8K5N2 D3DS69

Explore the universe of human proteins at neXtProt for RABGGTA: NX_Q92696

Explore proteomics data for RABGGTA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys38, Lys329, Lys402, Lys428
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for RABGGTA (Q92696) (see all 7)
     GRNRPSH  QKSPEELA  QKECVLLK  LPQHTFRVIWT 


    See RABGGTA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004572.3  NP_878256.1  

    ENSEMBL proteins: 
     ENSP00000453596   ENSP00000382341   ENSP00000216840   ENSP00000453001   ENSP00000453890  
     ENSP00000453207   ENSP00000453201   ENSP00000452890  

    RABGGTA Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PTAR: Prenyltransferase alpha subunit repeat containing

    3 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR002088 Prenyl_trans_a
     IPR009087 RabGGT_asu_insert-domain

    Graphical View of Domain Structure for InterPro Entry Q92696

    ProtoNet protein and cluster: Q92696

    2 Blocks protein domains:
    IPB001611 Leucine-rich repeat signature
    IPB009087 Rab geranylgeranyltransferase


    UniProtKB/Swiss-Prot: PGTA_HUMAN, Q92696
    Similarity: Belongs to the protein prenyltransferase subunit alpha family
    Similarity: Contains 5 LRR (leucine-rich) repeats
    Similarity: Contains 6 PFTA repeats


    RABGGTA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PGTA_HUMAN, Q92696
    Function: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of
    Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A
    Catalytic activity: Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate
    Enzyme regulation: The enzymatic reaction requires the aid of a Rab escort protein (also called component A), such
    as CHM

         Genatlas biochemistry entry for RABGGTA:
    Rab geranyl-geranyltransferase B,type II,alpha subunit,2 kb upstream TGM1 (see symbol) in a head-to-head
    orientation,but not co-regulated in the terminal differentiation program of epidermal keratinocytes

         Enzyme Number (IUBMB): EC 2.5.1.601 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004663Rab geranylgeranyltransferase activity ISS--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0008318protein prenyltransferase activity ----
    GO:0017137Rab GTPase binding ISS--
         
    RABGGTA for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rabggta):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  integument 
     mortality/aging  pigmentation  reproductive system 

    RABGGTA for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RABGGTA
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RABGGTA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RABGGTA

    miRNA
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    miRTarBase miRNAs that target RABGGTA:
    hsa-mir-26b-5p (MIRT029542)

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    hsa-miR-1207-5p
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    Inhib. RNA
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    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RABGGTA

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RABGGTA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005968Rab-protein geranylgeranyltransferase complex ISS--

    RABGGTA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RABGGTA About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling events mediated by PRL
    Signaling events mediated by PRL


    1 BioSystems Pathway for RABGGTA
        Signaling events mediated by PRL


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RABGGTA
    Interactions:

        Search GeneGlobe Interaction Network for RABGGTA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for RABGGTA (Q926963 ENSP000002168404) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RABGGTBP536113, ENSP000003174734I2D: score=6 STRING: ENSP00000317473
    CHMP243863, ENSP000003503864I2D: score=1 STRING: ENSP00000350386
    RAB1AP628203, ENSP000003872864I2D: score=2 STRING: ENSP00000387286
    BMPR2Q138733, ENSP000003637084I2D: score=2 STRING: ENSP00000363708
    C12orf4Q9NQ893I2D: score=5 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS2018975
    GO:0007601visual perception TAS8380507
    GO:0018342protein prenylation ----
    GO:0018344protein geranylgeranylation ISS--

    RABGGTA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RABGGTA (PGTA)

    4 DrugBank Compounds for RABGGTA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    FARNESYL-- --target--10592235
    FARNESYL DIPHOSPHATE-- --target--10592235
    GERANYLGERANYL DIPHOSPHATE-- --target--10592235
    N-Formylmethionine-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RABGGTA gene (2 alternative transcripts): 
    NM_004581.5  NM_182836.2  

    Unigene Cluster for RABGGTA:

    Rab geranylgeranyltransferase, alpha subunit
    Hs.377992  [show with all ESTs]
    Unigene Representative Sequence: NM_004581
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000561055 ENST00000560521 ENST00000399409(uc001wof.3) ENST00000216840(uc001wog.3)
    ENST00000560243 ENST00000559551 ENST00000559974 ENST00000558376 ENST00000560777
    ENST00000560998 ENST00000558649 ENST00000559850 ENST00000560871 ENST00000543002
    ENST00000558534 ENST00000558936 ENST00000559586 ENST00000560127
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate RABGGTA:
    hsa-miR-1207-5p
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    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat RABGGTA
      QuantiFast Probe-based Assays in human, mouse, rat RABGGTA

    Additional mRNA sequence: 

    AK291347.1 AK292613.1 BC003093.1 CR541797.1 Y08200.1 

    Selected DOTS entries (see all 29):

    DT.453156  DT.100857644  DT.100857647  DT.100857658  DT.95132263  DT.120794919  DT.100759641  DT.100857645 
    DT.101969573  DT.95132254  DT.95132264  DT.100857666  DT.95132261  DT.100857642  DT.100857648  DT.100857663 
    DT.91764236  DT.100857655  DT.91764234  DT.100691784  DT.100758057  DT.100839272  DT.100857650  DT.100857665 

    Selected AceView cDNA sequences (see all 241):

    BX343004 BU727251 CR608269 BQ008417 BU188317 CA487433 CR626838 BX394736 
    AU125148 BE733834 CD370056 BM754330 BI753321 BQ071802 CR607792 BX438758 
    CB528918 BX449847 BM983576 BG117978 BE512861 AW952228 CR621414 CF131477 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RABGGTA (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^
    SP1:                                      -     -                 -                                                                                   -     -   
    SP2:                                                              -                                                                                   -     -   
    SP3:                                                                                                                                                  -     -   
    SP4:                                      -     -                 -                                                     -     -     -     -                     
    SP5:                                                                                                                                                            

    ExUns: 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18
    SP1:                                            -                                         -               
    SP2:                                            -                                         -               
    SP3:                                            -                                                         
    SP4:                                                                                                      
    SP5:                                            -                                                         


    ECgene alternative splicing isoforms for RABGGTA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RABGGTA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGGCAGCGT
    RABGGTA Expression
    About this image

    RABGGTA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RABGGTA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.377992
        Custom PCR Arrays for RABGGTA
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RABGGTA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RABGGTA gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rabggta1 , 5 Rab geranylgeranyl transferase, a subunit1, 5 86.3(n)1
    90.83(a)1
      14 (28.19 cM)5
    561871  NM_019519.21  NP_062392.11 
     557158775 
    lizard
    (Anolis carolinensis)
    Reptilia RABGGTA6
    Rab geranylgeranyltransferase, alpha subunit
    68(a)
    1 ↔ 1
    GL343400.1(202797-224194)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia CF222571.12   -- 72.42(n)    CF222571.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rabggta1 Rab geranylgeranyltransferase, alpha subunit 62.58(n)
    58.08(a)
      767725  NM_001076663.1  NP_001070131.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG120071 , 3 RAB-protein geranylgeranyltransferase3
    CG120071
    37(a)3
    51.64(n)1
    42.69(a)1
      82F13
    406171  NM_141255.21  NP_649512.11 
    worm
    (Caenorhabditis elegans)
    Secernentea M57.21 , 3 M57.21 30(a)3
    43.51(n)1
    33.89(a)1
      IV(3527360-3532268)3
    1771131  NM_067966.41  NP_500367.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BET4(YJL031C)4 Alpha subunit of Type II geranylgeranyltransferase more   --   10(387438-386368) 853421  NP_012503.2 


    ENSEMBL Gene Tree for RABGGTA (if available)
    TreeFam Gene Tree for RABGGTA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RABGGTA gene
    1 SIMAP similar gene for RABGGTA using alignment to 8 protein entries:     PGTA_HUMAN (see all proteins):
    DKFZp686I14200

    RABGGTA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RABGGTA (see all 270)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1439527141,2
    --24734422(+) GGGGTA/CATGGG 2 -- int10--------
    rs1472969651,2
    --24734536(+) CCAGTC/GCCAGC 2 -- int10--------
    rs1392930281,2
    --24734537(+) CAGTCC/TCAGCC 2 -- int10--------
    rs21801961,2
    C,F,A,H--24734645(-) TTCTGC/TGCCAT 2 -- int112Minor allele frequency- T:0.13NS EA NA 1416
    rs1446459771,2
    C--24734650(+) GCAGA-/AAGAAGGA 2 -- int10--------
    rs1862417661,2
    --24734676(+) CATGTC/GTCTTC 2 -- int10--------
    rs1430876881,2
    --24734761(+) GAGGGC/TCTCTC 2 -- ut310--------
    rs782230231,2
    C,F--24734762(+) AGGGCC/TTCTCC 2 -- ut314Minor allele frequency- T:0.17WA CSA 124
    rs1995024131,2
    C--24734905(+) CCCTGC/AAGGTT 4 /L syn11Minor allele frequency- A:0.00EU 543
    rs1153837481,2
    C--24734914(+) TTGAGG/AAGGAC 4 /L syn11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for RABGGTA (24734744 - 24740945 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RABGGTA: --
    Human Gene Mutation Database (HGMD): RABGGTA
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RABGGTA
    DNA2.0 Custom Variant and Variant Library Synthesis for RABGGTA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601905    OMIM disorders: --

    7 diseases for RABGGTA:    About MalaCards
    choroideremia    hermansky-pudlak syndrome    choroiditis    retinal degeneration
    retinitis    malaria    colorectal cancer


    RABGGTA for disorders           About GeneDecksing

    Genetic Association Database (GAD): RABGGTA

    Export disorders for RABGGTA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RABGGTA gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with RABGGTA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and chromosomal localization of the genes encoding the alpha- and beta-subunits of human Rab geranylgeranyl transferase: the 3' end of the alpha-subunit gene overlaps with the transglutaminase 1 gene promoter. (PubMed id 8954794)1, 2, 3 van Bokhoven H....Seabra M.C. (Genomics 1996)
    2. The genes encoding geranylgeranyl transferase alpha-subunit and transglutaminase 1 are very closely linked but not functionally related in terminally differentiating keratinocytes. (PubMed id 9196026)1, 2, 9 Song H.-J.... Steinert P.M. (Biochem. Biophys. Res. Commun. 1997)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. (PubMed id 7991565)1, 2 Farnsworth C.C.... Glomset J.A. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5875 HGNC: 9795 AceView: RABGGTA Ensembl:ENSG00000100949 euGenes: HUgn5875
    ECgene: RABGGTA H-InvDB: RABGGTA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RABGGTA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RABGGTA gene:
    Search GeneIP for patents involving RABGGTA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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