RABGEF1 Gene
protein-coding GIFtS: 52
GCID: GC07P066205
|
|
RAB guanine nucleotide exchange factor (GEF) 1
| |
Aliases
for RABGEF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RAB Guanine Nucleotide Exchange Factor (GEF) 11 2 | | RAP12 3 | | RABEX51 2 3 5 | | Rab5 GDP/GTP Exchange Factor2 | | Rabex-53 | | Rabex-53 | | Rabaptin-5-Associated Exchange Factor For Rab52 3 | | |
Export aliases for RABGEF1 gene to outside databasesPrevious GC identifers: GC07P065544 GC07P065617 GC07P065649 GC07P065732 GC07P065843 GC07P066094 GC07P062390 |
Summaries
for RABGEF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RABGEF1:
RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and itserves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997(PubMed 9323142)).(supplied by OMIM, Mar 2010)
UniProtKB/Swiss-Prot: RABX5_HUMAN, Q9UJ41Function: Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membranefusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as aubiquitin ligase (By similarity)
Gene Wiki entry for RABGEF1
|
Genomic Views
for RABGEF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079593.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RABGEF1 gene promoter:
ER-alpha HSF1 (long) MyoD CUTL1 MIF-1 C/EBPalpha HEN1 HFH-1 HSF1short TGIF
Other transcription factors
Search SABiosciences Chromatin IP Primers for RABGEF1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RABGEF1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q11.21 Ensembl cytogenetic band: 7q11.21 HGNC cytogenetic band: 7q11.21RABGEF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P066205: view genomic region
(about GC identifiers)
Start:
|
66,205,643 bp from pter |
End:
|
66,276,451 bp from pter |
Size:
|
70,809 bases |
Orientation:
|
plus strand |
2 alternative locations:
| Chr7+ 66,093,868-66,276,446 | Chr7+,CRA_TCAG 65,543,205-65,614,013 |
|
Proteins
for RABGEF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RABX5_HUMAN, Q9UJ41 (See
protein sequence)Recommended Name: Rab5 GDP/GTP exchange factor Size: 708 amino acids; 79371 Da
Subunit: Interacts with RGS14; the interaction is GTP-dependent (By similarity). Heterodimer with RABEP1. Theheterodimer binds RAB4A and RAB5A that have been activated by GTP-binding. Interacts with RAB21, and with 100-foldlower affinity also with RAB22. Binds TSC2, GGA1, GGA2, GGA3, AP1G1 and AP1G2. Interacts with ubiquitinated EGFR
Subcellular location: Cytoplasm. Early endosome. Recycling endosome
4 PDB 3D structures from  and Proteopedia  for RABGEF1:1TXU (3D)
2C7M (3D)
2C7N (3D)
2OT3 (3D)
Secondary accessions: Q3HKR2 Q3HKR3 Q53FG0Alternative splicing: 3 isoforms: Q9UJ41-1 Q9UJ41-2 Q9UJ41-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RABGEF1: NX_Q9UJ41
Post-translational modifications:
Monoubiquitinated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UJ41
RABGEF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055319.1
ENSEMBL proteins: ENSP00000284957 ENSP00000415815 ENSP00000415503 ENSP00000403429 ENSP00000390480
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005769 | early endosome |
IEA | -- | | GO:0055037 | recycling endosome |
IEA | -- |
RABGEF1 for ontologies About GeneDecksing
RABGEF1 Antibody Products:
Assay Products for RABGEF1: |
Protein
Domains /
Families
for RABGEF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RABGEF1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UJ41ProtoNet protein and cluster: Q9UJ41 UniProtKB/Swiss-Prot: RABX5_HUMAN, Q9UJ41Similarity: Contains 1 A20-type zinc fingerSimilarity: Contains 1 VPS9 domain |
Function
for RABGEF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RABX5_HUMAN, Q9UJ41Function: Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membranefusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as aubiquitin ligase (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RABGEF1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RABGEF1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RABGEF1 (NM_014504) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RABGEF1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RABGEF1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RABGEF1 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
RABGEF1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RABGEF1:
Animal Models:
Mouse knock-outs for RABGEF1: Rabgef1tm2Glli Rabgef1tm1Glli
5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Rabgef1):
RABGEF1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RABGEF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Normal wtCFTR traffic / Sorting endosome formation | | | 2 | Clathrin-dependent protein traffic | | | 3 | Lymphocyte Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for RABGEF1
1 
Cell Signaling Technology (CST) Pathway for RABGEF1
3  GeneGo (Thomson Reuters) Pathways for RABGEF1
RABGEF1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RABGEF1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 22)
5/24 Interacting proteins for RABGEF1 (Q9UJ411, 2, 3 ENSP000002849574) via UniProtKB, MINT, STRING, and/or I2D (see all 24)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| UBB | P0CG471, 3, ENSP000003046974 | EBI-913954,EBI-413034 I2D:
score=2 STRING: ENSP00000304697 | | RNF11 | Q9Y3C52, 3 | MINT-60856 I2D:
score=3 | | KXD1 | Q9BQD31, 2, 3, ENSP000002223074 | EBI-913954,EBI-739657 MINT-67747 I2D:
score=4 STRING: ENSP00000222307 | | EGFR | P005331, 3, ENSP000002754934 | EBI-913954,EBI-297353 I2D:
score=1 STRING: ENSP00000275493 | | YWHAB | P319462, 3, ENSP000003001614 | MINT-50957 I2D:
score=4 STRING: ENSP00000300161 |
About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006897 | endocytosis |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- |
RABGEF1 for ontologies About GeneDecksing
|
Drugs & Compounds
for RABGEF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RABGEF1 for compounds About GeneDecksing
 Browse Tocris compounds for RABGEF1
1 HMDB Compound for RABGEF1 About this table
2 Novoseek chemical compound relationships for RABGEF1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gdp |
69 |
2 |
11419942 (2) |
| gtp |
48.8 |
2 |
17473071 (1), 11419942 (1) |
Search CenterWatch for drugs/clinical trials and news about RABGEF1 / RABX5
|
Transcripts
for RABGEF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RABGEF1 gene: NM_014504.2 Unigene Cluster for RABGEF1: RAB guanine nucleotide exchange factor (GEF) 1 Hs.530053 [show with all ESTs]Unigene Representative Sequence: NM_0145047 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000284957 ENST00000450873 ENST00000442563 ENST00000439720 ENST00000484547
ENST00000461017 ENST00000437078
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RABGEF1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RABGEF1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RABGEF1 (NM_014504) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RABGEF1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RABGEF1 |
Additional cDNA sequence: AJ250042.1 AK001702.1 AK056864.1 AK223329.1 AK290678.1 AK303006.1 BC015330.1 BT007107.1 DQ230533.1 DQ230534.1 DQ230535.1 21 DOTS entries: DT.447451 DT.97811581 DT.97820243 DT.446296 DT.95274105 DT.95274104 DT.102840124 DT.103852 DT.121063296 DT.91701387 DT.99933786 DT.100780554 DT.121063372 DT.91755396 DT.95193032 DT.95364850 DT.100788664 DT.40279192 DT.40316869 DT.95333312 DT.97772695 24/329 AceView cDNA sequences (see all 329): AI597889 BU431372 BU101729 BM721441 BM684150 BU902852 AW079276 BC015330 AI130941 AW196783 BI818568 BF431815 AW593820 AA468867 AA703087 AI263012 AA426144 AI889830 BQ010311 BM724501 AI471735 AA055399 AI341368 AA883708
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for RABGEF1 (see all 13) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12a | · |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | - | | - | | - | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | - | | - | | - | | - | | - | | | | | |
| ExUns: | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | · | 15c |
|---|
|
| SP1: | | | | | - | | | | | | | | |
| SP2: | | | | | - | | | | | | | | |
| SP3: | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | |
| SP5: | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for RABGEF1
|
Expression
for RABGEF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RABGEF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGCCCCAGG
About this image
See RABGEF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RABGEF1
SOURCE GeneReport for Unigene cluster: Hs.530053
SABiosciences Custom PCR Arrays for RABGEF1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RABGEF1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RABGEF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RABGEF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RABGEF1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RABGEF1 |
Orthologs
for RABGEF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RABGEF1 gene from 7/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RABGEF11 |
RAB guanine nucleotide exchange factor (GEF) 1 |
80.79(n)
92.26(a) |
|
417548 XM_415796.3 XP_415796.2 |
African clawed frog
(Xenopus laevis) |
Amphibia |
BJ636051.12 |
-- |
78.08(n) |
|
BJ636051.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc659442 |
RAB guanine nucleotide exchange factor (GEF) 1 |
78.11(n) |
|
393816 BC061953.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Rabex-51 |
CG9139-PA |
48.42(n)
35.76(a) |
|
38144 NM_138249.2 NP_612093.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
rabx-51 |
Protein RABX-5 |
48.21(n)
37.47(a) |
|
176481 NM_066936.3 NP_499337.2 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
VPS96VPS9B6 |
Vacuolar sorting protein 9 (VPS9) domain protein |
15(a)12(a) |
many ↔ manymany ↔ many |
3(6866806-6869479) 5(2888655-2892016) |
rice
(Oryza sativa) |
Liliopsida |
Os03g08427001 |
hypothetical protein |
48.89(n)
36.36(a) |
|
4334742 NM_001058393.1 NP_001051858.1 |
ENSEMBL Gene Tree for RABGEF1 (if available)
TreeFam Gene Tree for RABGEF1 (if available) |
Paralogs
for RABGEF1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RABGEF1 gene
- GAPVD12 KCTD72
11 SIMAP similar genes for RABGEF1 using alignment to 4 protein entries: RABX5_HUMAN (see all proteins):KCTD7 FAM138A FAM138B FAM138C FAM138F OK/SW-cl.41
C12orf23 KIAA1651 CNOT2 GNPTAB ZFAND6
RABGEF1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for RABGEF1
PGOHUM00000250871
|
Genomic Variants
for RABGEF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RABGEF1 (66205643 - 66276451 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RABGEF1: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for RABGEF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 RABGEF1 for disorders About MalaCards
RABGEF1 for disorders About GeneDecksing
OMIM gene information: 609700
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: RABGEF1 (1 document)
Export disorders for RABGEF1 gene to outside databases
|
Publications
for RABGEF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RABGEF1 gene, integrated from 9 sources (see all 44):
(articles sorted by number of sources associating them with RABGEF1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex. (PubMed id 12505986)1, 2, 3 Mattera R.... Bonifacino J.S. (2003)
- Seven genes that are differentially transcribed in colorectal tumor cell lines. (PubMed id 11098082)1, 2, 3 Nimmrich I....Muller O. (2000)
- Functional synergy between Rab5 effector Rabaptin-5 and exchange factor Rabex-5 when physically associated in a complex. (PubMed id 11452015)1, 2, 9 Lippe R.... Zerial M. (2001)
- Structural basis for Rab GTPase activation by VPS9 domain exchange factors. (PubMed id 17450153)1, 2 Delprato A. and Lambright D.G. (2007)
- Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin. (PubMed id 16499958)1, 2 Penengo L.... Schneider T.R. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5. (PubMed id 15339665)1, 2 Delprato A.... Lambright D.G. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. (PubMed id 9323142)1, 2 Horiuchi H.... Zerial M. (1997)
|
External Searches for RABGEF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing RABGEF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing RABGEF1 gene
(According to HUGE)
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Specialized Databases showing RABGEF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for RABGEF1 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for RABGEF1 gene:
Search GeneIP for patents involving RABGEF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RABGEF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RABGEF1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RABGEF1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RABGEF1 | | | OriGene Protein Over-expression Lysate for RABGEF1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RABGEF1 | | OriGene 3'-UTR Clone for RABGEF1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RABGEF1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RABGEF1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RABGEF1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RABGEF1 | | OriGene Custom Protein Services for RABGEF1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RABGEF1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RABGEF1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RABGEF1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RABGEF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RABGEF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RABGEF1 |
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| | | | Search Tocris compounds for RABGEF1 |
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 | | | RABGEF1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RABGEF1 |
|  |  |  | | | | ThermoFisher Antibodies for RABGEF1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RABGEF1 |
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