Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RABGAP1 Gene

protein-coding   GIFtS: 51
GCID: GC09P125703

RAB GTPase Activating Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
RAB GTPase Activating Protein 11 2     GAPCENA2
Rab6 GTPase Activating Protein (GAP And Centrosome-Associated)1 2     TBC1D112
Rab6 GTPase-Activating Protein GAPCenA2 3     Rab GTPase-Activating Protein 12
GAP And Centrosome-Associated Protein2 3     Rab6 GTPase Activating Protein, GAPCenA2
Member 111     TBC1 Domain Family, Member 112
TBC1 Domain Family1     

External Ids:    HGNC: 171551   Entrez Gene: 236372   Ensembl: ENSG000000114547   UniProtKB: Q9Y3P93   

Export aliases for RABGAP1 gene to outside databases

Previous GC identifers: GC09P121079 GC09P122782 GC09P124743 GC09P095318


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for RABGAP1 Gene:
RABGAP1 (RAB GTPase activating protein 1) is a protein-coding gene. Diseases associated with RABGAP1 include ocular hypertension, and atopic dermatitis. GO annotations related to this gene include tubulin binding and GTPase activator activity. An important paralog of this gene is TBC1D12.

UniProtKB/Swiss-Prot: RBGP1_HUMAN, Q9Y3P9
Function: May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by
centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RABGAP1 gene promoter:
         Pax-5   CUTL1   HNF-3beta   GATA-1   E47   HEN1   SRY   Hand1   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRABGAP1 promoter sequence
   Search Chromatin IP Primers for RABGAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RABGAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q33.2   HGNC cytogenetic band: 9q34.11

RABGAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RABGAP1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P125703:  view genomic region     (about GC identifiers)

Start:
125,703,112 bp from pter      End:
125,867,147 bp from pter
Size:
164,036 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RBGP1_HUMAN, Q9Y3P9 (See protein sequence)
Recommended Name: Rab GTPase-activating protein 1  
Size: 1069 amino acids; 121737 Da
Subunit: Interacts with RAB6A and tubulin gamma
Sequence caution: Sequence=AAF28917.1; Type=Frameshift; Positions=Several; Sequence=AAH20609.1; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAH54492.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=AK022408; Type=Miscellaneous discrepancy;
Note=Intron retention; Sequence=CAB40267.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B9A6L2 Q05CW2 Q6ZMY1 Q9HA28 Q9P0E2 Q9UG67
Alternative splicing: 4 isoforms:  Q9Y3P9-1   Q9Y3P9-2   Q9Y3P9-3   Q9Y3P9-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RABGAP1: NX_Q9Y3P9

Explore proteomics data for RABGAP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RABGAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036329.3  
    ENSEMBL proteins: 
     ENSP00000414386   ENSP00000362751   ENSP00000384119   ENSP00000416327   ENSP00000362747  

    RABGAP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RABGAP1
    GenScript Custom Purified and Recombinant Proteins Services for RABGAP1
    Novus Biologicals RABGAP1 Proteins
    Novus Biologicals RABGAP1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RABGAP1

    RABGAP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RABGAP1
    Novus Biologicals RABGAP1 Antibodies
    Abcam antibodies for RABGAP1
    Cloud-Clone Corp. Antibodies for RABGAP1
    ThermoFisher Antibody for RABGAP1
    LSBio Antibodies in human, mouse, rat for RABGAP1

    RABGAP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RABGAP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RABGAP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RABGAP1
    Cloud-Clone Corp. CLIAs for RABGAP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    5 InterPro protein domains:
     IPR022164 Kinesin-like
     IPR000195 Rab-GTPase-TBC_dom
     IPR011993 PH_like_dom
     IPR006020 PTB/PI_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9Y3P9

    ProtoNet protein and cluster: Q9Y3P9

    2 Blocks protein domains:
    IPB000195 RabGAP/TBC domain
    IPB006020 Phosphotyrosine interaction domain


    UniProtKB/Swiss-Prot: RBGP1_HUMAN, Q9Y3P9
    Similarity: Contains 1 PID domain
    Similarity: Contains 1 Rab-GAP TBC domain


    RABGAP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBGP1_HUMAN, Q9Y3P9
    Function: May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by
    centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005096GTPase activator activity TAS10202141
    GO:0005097Rab GTPase activator activity IEA--
    GO:0005515protein binding IPI--
    GO:0015631tubulin binding TAS10202141
         
    RABGAP1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RABGAP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RABGAP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RABGAP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RABGAP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target RABGAP1:
    hsa-mir-92a-3p (MIRT048971), hsa-mir-192-5p (MIRT004150), hsa-mir-93-3p (MIRT038856), hsa-mir-504-5p (MIRT041085), hsa-mir-9-5p (MIRT021450), hsa-mir-21-5p (MIRT030972)

    Block miRNA regulation of human, mouse, rat RABGAP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RABGAP1 (see all 51):
    hsa-miR-142-5p hsa-miR-520f hsa-miR-300 hsa-miR-3616-5p hsa-miR-146a hsa-miR-199a-3p hsa-miR-200a hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidRABGAP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RABGAP1
    Predesigned siRNA for gene silencing in human, mouse, rat RABGAP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RABGAP1

    Clone
    Products:
         
    OriGene clones in human, mouse for RABGAP1 (see all 8)
    OriGene ORF clones in mouse, rat for RABGAP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RABGAP1 (NM_014857)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RABGAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RABGAP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RABGAP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for RABGAP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RABGAP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RBGP1_HUMAN, Q9Y3P9: Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
    Note=Predominantly cytosolic but also associated with the centrosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    golgi apparatus2
    endoplasmic reticulum1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome TAS10202141
    GO:0005829cytosol IEA--
    GO:0005875microtubule associated complex TAS10202141

    RABGAP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RABGAP1
    Interactions:

        GeneGlobe Interaction Network for RABGAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RABGAP1 (Q9Y3P91, 2, 3 ENSP000003627514) via UniProtKB, MINT, STRING, and/or I2D (see all 374)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007049cell cycle IEA--
    GO:0032313regulation of Rab GTPase activity ----
    GO:0043547positive regulation of GTPase activity TAS10202141

    RABGAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RABGAP1 (RBGP1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RABGAP1 gene: 
    NM_012197.3  

    Unigene Cluster for RABGAP1:

    RAB GTPase activating protein 1
    Hs.271341  [show with all ESTs]
    Unigene Representative Sequence: NM_012197
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000456584 ENST00000373647(uc004bnl.4 uc011lzh.2 uc011lzj.2)
    ENST00000459903 ENST00000317419(uc004bnm.1) ENST00000402311 ENST00000426918
    ENST00000485090 ENST00000493854 ENST00000475607 ENST00000468760(uc011lzi.2)
    ENST00000474707 ENST00000480054 ENST00000373643
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RABGAP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RABGAP1 (see all 51):
    hsa-miR-142-5p hsa-miR-520f hsa-miR-300 hsa-miR-3616-5p hsa-miR-146a hsa-miR-199a-3p hsa-miR-200a hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidRABGAP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RABGAP1
    Predesigned siRNA for gene silencing in human, mouse, rat RABGAP1
    Clone
    Products:
         
    OriGene clones in human, mouse for RABGAP1 (see all 8)
    OriGene ORF clones in mouse, rat for RABGAP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RABGAP1 (NM_014857)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RABGAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RABGAP1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RABGAP1
    OriGene qSTAR qPCR primer pairs in human, mouse for RABGAP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RABGAP1
      QuantiTect SYBR Green Assays in human, mouse, rat RABGAP1
      QuantiFast Probe-based Assays in human, mouse, rat RABGAP1

    Additional mRNA sequence: 

    AB449897.1 AF088073.1 AF161357.1 AJ011679.2 AK022408.1 AK294531.1 AL050195.1 BC020609.1 
    BC054492.1 

    11 DOTS entries:

    DT.411210  DT.101981434  DT.97793344  DT.100816613  DT.100739086  DT.121193341  DT.92429530  DT.100727831 
    DT.101970004  DT.91974384  DT.92039753 

    Selected AceView cDNA sequences (see all 184):

    AI635424 AA330130 BU500490 BQ051083 CD675204 BU626174 CD245525 AA630344 
    BX106596 W38903 BQ431522 AI279078 AI753933 BM994201 CD699392 AA836444 
    BG679164 BI335843 CK820748 BQ876645 AA713573 AA588320 CB146355 AU184939 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RABGAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCGAGGTC
    RABGAP1 Expression
    About this image

    RABGAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RABGAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.271341
        Custom PCR Arrays for RABGAP1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RABGAP1
    OriGene qSTAR qPCR primer pairs in human, mouse for RABGAP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RABGAP1
    QuantiTect SYBR Green Assays in human, mouse, rat RABGAP1
    QuantiFast Probe-based Assays in human, mouse, rat RABGAP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RABGAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for RABGAP1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rabgap11 , 5 RAB GTPase activating protein 11, 5 91.04(n)1
    97.84(a)1
      2 (24.19 cM)5
    2278001  NM_146121.21  NP_666233.21 
     374432795 
    chicken
    (Gallus gallus)
    Aves RABGAP11 RAB GTPase activating protein 1 82.54(n)
    93.73(a)
      417106  XM_415391.4  XP_415391.2 
    lizard
    (Anolis carolinensis)
    Reptilia RABGAP16
    RAB GTPase activating protein 1
    78(a)
    1 ↔ 1
    GL343751.1(211256-255062)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX708714.12   -- 81.19(n)    BX708714.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5596321 rab GTPase-activating protein 1-like 72.71(n)
    84.14(a)
      559632  XM_003201609.2  XP_003201657.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta GapcenA1 GapcenA 49.73(n)
    44.24(a)
      38945  NM_001104079.4  NP_001097549.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tbc-111 tbc-11 49.47(n)
    43.84(a)
      180444  NM_075778.2  NP_508179.2 


    ENSEMBL Gene Tree for RABGAP1 (if available)
    TreeFam Gene Tree for RABGAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RABGAP1 gene
    TBC1D122  TBC1D42  TBC1D142  RABGAP1L2  TBC1D12  EVI52  EVI5L2  
    5 SIMAP similar genes for RABGAP1 using alignment to 4 protein entries:     RBGP1_HUMAN (see all proteins):
    DKFZp686E1450    RABGAP1L    IDN4-GGTR7    TBC1D18    EVI5

    RABGAP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RABGAP1 (see all 2935)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1500647621,2
    --125701364(+) GTATTA/GTGTGA 1 -- us2k10--------
    rs1178649261,2
    C,F--125701366(+) ATTATG/ATGAGA 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1165013631,2
    F--125701389(+) GTAACA/GTTACT 1 -- us2k11Minor allele frequency- G:0.08WA 118
    rs37583321,2
    C,F,A,H--125701431(-) CTATCA/CATCTA 1 -- us2k125Minor allele frequency- C:0.36EA NA NS WA CSA 3977
    rs1905994831,2
    --125701532(+) GATCTC/TATTTT 1 -- us2k10--------
    rs109858271,2
    C,F--125701608(+) CATGGG/TTTTTT 1 -- us2k18Minor allele frequency- T:0.40NA WA CSA EA 368
    rs1810667581,2
    --125701671(+) GTCTCC/GAACTC 1 -- us2k10--------
    rs1453827331,2
    --125701704(+) CCTCAG/TCCTCC 1 -- us2k10--------
    rs357368451,2
    C--125701760(+) TTATT-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.00CSA 2
    rs2012072101,2
    --125701768(+) AAAAA-/TTTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RABGAP1 (125703112 - 125867147 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RABGAP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659860CNV Deletion23128226
    nsv517807CNV Loss19592680
    nsv831717CNV Gain17160897
    nsv893825CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RABGAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for RABGAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    7 diseases for RABGAP1:    
    About MalaCards
    ocular hypertension    atopic dermatitis    dermatitis    hypertension
    schizophrenia    retinitis    malaria


    RABGAP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RABGAP1
    Human Genome Epidemiology (HuGE) Navigator: RABGAP1 (1 document)

    Export disorders for RABGAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RABGAP1 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with RABGAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome. (PubMed id 10202141)1, 2, 3 Cuif M.-H....Goud B. (EMBO J. 1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PubMed id 19077034)1, 2 Ishibashi K.... Fukuda M. (Genes Cells 2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. A role for the Rab6A' GTPase in the inactivation of the Mad2-spindle checkpoint. (PubMed id 16395330)2, 9 Miserey-Lenkei S.... Goud B. (EMBO J. 2006)
    6. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    7. All members of the EPI64 subfamily of TBC/RabGAPs also have GAP activities towards Ras. (PubMed id 23248241)1 Nagai H....Nakamura T. (J. Biochem. 2013)
    8. Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. (PubMed id 22354992)1 Popovic D....Dikic I. (Mol. Cell. Biol. 2012)
    9. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23637 HGNC: 17155 AceView: RABGAP1 Ensembl:ENSG00000011454 euGenes: HUgn23637
    ECgene: RABGAP1 H-InvDB: RABGAP1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RABGAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RABGAP1 gene:
    Search GeneIP for patents involving RABGAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RABGAP1  
     OriGene qPCR primer pairs and template standards for RABGAP1   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RABGAP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for RABGAP1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RABGAP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RABGAP1   OriGene Custom Protein Services for RABGAP1  

     
     
     Block miRNA regulation of human, mouse, rat RABGAP1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RABGAP1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RABGAP1 Predesigned siRNA for gene silencing in human, mouse, rat RABGAP1
     QuantiFast Probe-based Assays in human, mouse, rat RABGAP1 QuantiTect SYBR Green Assays in human, mouse, rat RABGAP1
     Custom PCR Arrays for RABGAP1 Search Chromatin IP Primers for RABGAP1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RABGAP1  GeneGlobe Interaction Network for RABGAP1
     Regulatory tfbs in RABGAP1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RABGAP1 GenScript cDNA clones with any tag delivered in your preferred vector for RABGAP1
     GenScript Custom Assay Services for RABGAP1 GenScript Custom overexpressing Cell Line Services for RABGAP1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RABGAP1 (RBGP1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RABGAP1 antibodies
     RABGAP1 proteins
     RABGAP1 lysates
     Antibodies for RABGAP1
     See all of Abcam's Antibodies, Kits and Proteins for RABGAP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RABGAP1
     Antibodies for RABGAP1
     ELISAs for RABGAP1
     CLIAs for RABGAP1



     Browse ESI BIO Cell Lines and PureStem Progenitors for RABGAP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RABGAP1
     SwitchGear 3'UTR luciferase reporter plasmids for RABGAP1
     SwitchGear Promoter luciferase reporter plasmids for RABGAP1
     ThermoFisher Antibody for RABGAP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RABGAP1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RABGAP1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RABGAP1
     LSBio Antibodies in human, mouse, rat for RABGAP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RABGAP1 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4