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RABEPK Gene

protein-coding   GIFtS: 57
GCID: GC09P127962

Rab9 Effector Protein With Kelch Motifs

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rab9 Effector Protein With Kelch Motifs1 2
40 KDa Rab9 Effector Protein2 3
RAB9P402 3
p402 3
bA65N13.12
Rab9 Effector P402

External Ids:    HGNC: 168961   Entrez Gene: 102442   Ensembl: ENSG000001369337   OMIM: 6059625   UniProtKB: Q7Z6M13   

Export aliases for RABEPK gene to outside databases

Previous GC identifers: GC09P125043 GC09P127002 GC09P097575


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RABEPK Gene:
RABEPK (Rab9 effector protein with kelch motifs) is a protein-coding gene. An important paralog of this gene is KLHDC2.

UniProtKB/Swiss-Prot: RABEK_HUMAN, Q7Z6M1
Function: Rab9 effector required for endosome to trans-Golgi network (TGN) transport

Gene Wiki entry for RABEPK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RABEPK gene promoter:
         AREB6   AML1a   GATA-3   COMP1   Sox9   XBP-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RABEPK promoter sequence
   Search Chromatin IP Primers for RABEPK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RABEPK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9q33.1-q33.3

RABEPK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RABEPK gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P127962:  view genomic region     (about GC identifiers)

Start:
127,962,821 bp from pter      End:
127,996,438 bp from pter
Size:
33,618 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RABEK_HUMAN, Q7Z6M1 (See protein sequence)
Recommended Name: Rab9 effector protein with kelch motifs  
Size: 372 amino acids; 40565 Da
Subunit: Interacts with PIP5K3. Interacts with RAB9 in its GTP-bound conformation
Secondary accessions: A8K403 O00568 Q69YR2 Q6FHA4 Q6IBG7 Q6P092 Q86Y76 Q9BWB1
Alternative splicing: 2 isoforms:  Q7Z6M1-1   Q7Z6M1-2   

Explore the universe of human proteins at neXtProt for RABEPK: NX_Q7Z6M1

Explore proteomics data for RABEPK at MOPED

Post-translational modifications: 

  • Phosphorylated on Ser residues most probably by PIP5K31
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RABEPK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001167623.1  NP_001167624.1  NP_005824.2  

    ENSEMBL proteins: 
     ENSP00000362645   ENSP00000362639   ENSP00000402234   ENSP00000377683   ENSP00000259460  
     ENSP00000377682  

    RABEPK Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for RABEPK

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR006652 Kelch_1
     IPR011498 Kelch_2
     IPR015915 Kelch-typ_b-propeller

    Graphical View of Domain Structure for InterPro Entry Q7Z6M1

    ProtoNet protein and cluster: Q7Z6M1

    1 Blocks protein domain: IPB011498 Kelch

    UniProtKB/Swiss-Prot: RABEK_HUMAN, Q7Z6M1
    Similarity: Contains 5 Kelch repeats


    Find genes that share domains with RABEPK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RABEK_HUMAN, Q7Z6M1
    Function: Rab9 effector required for endosome to trans-Golgi network (TGN) transport

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with RABEPK           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RABEPK:
     Decreased Hepatitis C virus re  Decreased Tat-dependent transc 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RABEPK
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RABEPK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RABEPK

    miRNA
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    miRTarBase miRNAs that target RABEPK:
    hsa-mir-1 (MIRT023617)

    Block miRNA regulation of human, mouse, rat RABEPK using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate RABEPK:
    hsa-miR-412
    SwitchGear 3'UTR luciferase reporter plasmidRABEPK 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RABEPK
    Predesigned siRNA for gene silencing in human, mouse, rat RABEPK

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RABEPK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RABEK_HUMAN, Q7Z6M1: Cytoplasm. Endosome membrane. Note=Interaction with PIP5K3 and subsequent phosphorylation
    recruits it to the endosomal membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane4
    cytosol2
    nucleus2
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome TAS9230071
    GO:0005886plasma membrane IDA--
    GO:0010008endosome membrane IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with RABEPK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RABEPK About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin dependent protein traffic
    Transport Clathrin coated vesicle cycle0.66

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RABEPK
        Transport Clathrin-coated vesicle cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RABEPK
    Interactions:

        Search GeneGlobe Interaction Network for RABEPK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for RABEPK (Q7Z6M12, 3 ENSP000003626394) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TMEM98Q9Y2Y62, 3, ENSP000002617134MINT-8267852 I2D: score=2 STRING: ENSP00000261713
    ZYXQ159422, 3, ENSP000003244224MINT-8267863 I2D: score=2 STRING: ENSP00000324422
    PORP164352, 3MINT-8267830 I2D: score=2 
    PRKRAO755692, 3MINT-8267841 I2D: score=2 
    RAB9AP511513, ENSP000004201274I2D: score=3 STRING: ENSP00000420127
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006898receptor-mediated endocytosis TAS9230071
    GO:0006904vesicle docking involved in exocytosis TAS9230071

    Find genes that share ontologies with RABEPK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RABEPK (RABEK)

    1 HMDB Compound for RABEPK    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RABEPK gene (3 alternative transcripts): 
    NM_001174152.1  NM_001174153.1  NM_005833.3  

    Unigene Cluster for RABEPK:

    Rab9 effector protein with kelch motifs
    Hs.19012  [show with all ESTs]
    Unigene Representative Sequence: AL832249
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373544(uc004bph.2) ENST00000373538(uc004bpk.3) ENST00000416065
    ENST00000394125(uc004bpi.3) ENST00000259460(uc004bpj.3) ENST00000394124

    miRNA
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    Block miRNA regulation of human, mouse, rat RABEPK using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate RABEPK:
    hsa-miR-412
    SwitchGear 3'UTR luciferase reporter plasmidRABEPK 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RABEPK
    Predesigned siRNA for gene silencing in human, mouse, rat RABEPK
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): RABEPK (NM_005833)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RABEPK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RABEPK
    Primer
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    OriGene qPCR primer pairs and template standards for RABEPK
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RABEPK
      QuantiTect SYBR Green Assays in human, mouse, rat RABEPK
      QuantiFast Probe-based Assays in human, mouse, rat RABEPK

    Additional mRNA sequence: 

    AK290768.1 AL832249.1 BC000503.2 BC047023.1 BC053541.1 BC065725.1 CR456837.1 CR541851.1 
    Z97074.1 

    16 DOTS entries:

    DT.100027728  DT.453514  DT.99934861  DT.100827585  DT.95176410  DT.95176411  DT.100827580  DT.100827582 
    DT.100720428  DT.95176405  DT.65286531  DT.100698021  DT.121185592  DT.121185654  DT.87009022  DT.100716633 

    Selected AceView cDNA sequences (see all 224):

    CR616433 BC047023 CR591445 NM_005833 BG696326 BQ691482 BU839055 CR600864 
    N26009 BX384714 CB529186 BM462349 CK821573 AA336559 CR541851 BX462531 
    AI572824 BU622216 CR616448 CR590651 CR608411 BE270409 BE315343 CD365135 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RABEPK (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e
    SP1:        -     -                       -                       -           -                       -                           
    SP2:                                      -                       -           -                       -                           
    SP3:                                      -                 -     -           -                       -                           
    SP4:                                      -                       -     -     -                                                   
    SP5:                                      -           -     -     -     -     -     -     -           -                           


    ECgene alternative splicing isoforms for RABEPK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RABEPK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAAAGCCA
    RABEPK Expression
    About this image


    RABEPK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    RABEPK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RABEPK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.19012
        Custom PCR Arrays for RABEPK
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    QuantiFast Probe-based Assays in human, mouse, rat RABEPK
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RABEPK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RABEPK gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rabepk1 , 5 Rab9 effector protein with kelch motifs1, 5 82.62(n)1
    78.76(a)1
      2 (22.94 cM)5
    2277461  NM_145522.41  NP_663497.21 
     347775565 
    chicken
    (Gallus gallus)
    Aves RABEPK1 Rab9 effector protein with kelch motifs 61.63(n)
    54.95(a)
      772357  NM_001080891.1  NP_001074360.1 
    lizard
    (Anolis carolinensis)
    Reptilia RABEPK6
    Rab9 effector protein with kelch motifs
    63(a)
    1 ↔ 1
    AAWZ02037731(2417-4602)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.336752 Xenopus laevis transcribed sequence with weak similarity more 70.92(n)    BJ094688.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.176662 Transcribed sequence with weak similarity to protein more 71.29(n)    BQ074447.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g03009001 Os01g0300900 45.45(n)
    36.03(a)
      4325780  NM_001049354.1  NP_001042819.1 


    ENSEMBL Gene Tree for RABEPK (if available)
    TreeFam Gene Tree for RABEPK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RABEPK gene
    KLHDC22  KLHDC32  HCFC12  KLHDC12  LZTR12  KLHDC102  HCFC22  

    Find genes that share paralogs with RABEPK           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RABEPK
    PGOHUM00000248626


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RABEPK (see all 819)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1453922801,2
    C--127960880(+) CTATAA/GGTGCG 3 -- us2k10--------
    rs1869623011,2
    --127960956(+) TGGTCG/TTGAAC 3 -- us2k10--------
    rs8692481,2
    C,F,H--127961103(-) GCTCCT/CGGAGT 3 -- us2k117Minor allele frequency- C:0.09NS EA NA WA 2064
    rs768931431,2
    F--127961190(+) CAGACA/CTAAGA 3 -- us2k12Minor allele frequency- C:0.14CSA WA 120
    rs797553671,2
    C,F--127961237(+) AGAACC/TTATGG 3 -- us2k12Minor allele frequency- T:0.06WA EA 238
    rs1924598531,2
    C--127961253(+) AACTAA/CAACAA 3 -- us2k10--------
    rs575916011,2
    C--127961418(+) CTCTC-/TTTTTT 3 -- us2k10--------
    rs1442975001,2
    C--127961601(+) TTTAG-/TTGGGG 3 -- us2k10--------
    rs8280961,2
    C--127961602(-) CCCCCA/CACTAA 3 -- us2k11Minor allele frequency- C:0.00NA 2
    rs2016139931,2
    --127961603(+) TAGTT-/GGGGGG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for RABEPK (127962821 - 127996438 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RABEPK: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RABEPK
    DNA2.0 Custom Variant and Variant Library Synthesis for RABEPK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605962    OMIM disorders: --


    Find genes that share disorders with RABEPK           About GenesLikeMe

    Genetic Association Database (GAD): RABEPK
    Human Genome Epidemiology (HuGE) Navigator: RABEPK (2 documents)

    Export disorders for RABEPK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RABEPK gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with RABEPK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel Rab9 effector required for endosome-to-TGN transport. (PubMed id 9230071)1, 2, 3 Diaz E.... Pfeffer S.R. (J. Cell Biol. 1997)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. TIP47 is a key effector for Rab9 localization. (PubMed id 16769818)1, 2 Aivazian D.... Pfeffer S. (J. Cell Biol. 2006)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40. (PubMed id 14530284)1, 2 Ikonomov O.C.... Shisheva A. (J. Biol. Chem. 2003)
    7. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10244 HGNC: 16896 AceView: RAB9P40 Ensembl:ENSG00000136933 euGenes: HUgn10244
    ECgene: RABEPK H-InvDB: RABEPK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RABEPK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RABEPK gene:
    Search GeneIP for patents involving RABEPK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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