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Aliases for RABEP2 Gene

Aliases for RABEP2 Gene

  • Rabaptin, RAB GTPase Binding Effector Protein 2 2 3
  • Rabaptin-5beta 2 3 4
  • Rab GTPase-Binding Effector Protein 2 3
  • Rabaptin-5 Beta 3
  • RABPT5B 4
  • FRA 3

External Ids for RABEP2 Gene

Summaries for RABEP2 Gene

GeneCards Summary for RABEP2 Gene

RABEP2 (Rabaptin, RAB GTPase Binding Effector Protein 2) is a Protein Coding gene. Diseases associated with RABEP2 include pertussis. GO annotations related to this gene include growth factor activity and GTPase activator activity.

UniProtKB/Swiss-Prot for RABEP2 Gene

  • Plays a role in membrane trafficking and in homotypic early endosome fusion.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RABEP2 Gene

Genomics for RABEP2 Gene

Genomic Location for RABEP2 Gene

Start:
28,904,421 bp from pter
End:
28,936,526 bp from pter
Size:
32,106 bases
Orientation:
Minus strand

Genomic View for RABEP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RABEP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RABEP2 Gene

Regulatory Elements for RABEP2 Gene

Proteins for RABEP2 Gene

  • Protein details for RABEP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H5N1-RABE2_HUMAN
    Recommended name:
    Rab GTPase-binding effector protein 2
    Protein Accession:
    Q9H5N1
    Secondary Accessions:

    Protein attributes for RABEP2 Gene

    Size:
    569 amino acids
    Molecular mass:
    63543 Da
    Quaternary structure:
    • Heterodimer with RABGEF1. The dimer binds RAB5A that has been activated by GTP-binding
    SequenceCaution:
    • Sequence=BAB15594.1; Type=Frameshift; Positions=524; Evidence={ECO:0000305};

    Alternative splice isoforms for RABEP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RABEP2 Gene

Proteomics data for RABEP2 Gene at MOPED

Post-translational modifications for RABEP2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys105

No data available for DME Specific Peptides for RABEP2 Gene

Domains for RABEP2 Gene

Protein Domains for RABEP2 Gene

Suggested Antigen Peptide Sequences for RABEP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H5N1

UniProtKB/Swiss-Prot:

RABE2_HUMAN
Family:
  • Belongs to the rabaptin family.:
    • Q9H5N1
genes like me logo Genes that share domains with RABEP2: view

No data available for Gene Families for RABEP2 Gene

Function for RABEP2 Gene

Molecular function for RABEP2 Gene

UniProtKB/Swiss-Prot Function: Plays a role in membrane trafficking and in homotypic early endosome fusion.

Gene Ontology (GO) - Molecular Function for RABEP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with RABEP2: view

Phenotypes for RABEP2 Gene

GenomeRNAi human phenotypes for RABEP2:
genes like me logo Genes that share phenotypes with RABEP2: view

miRNA for RABEP2 Gene

miRTarBase miRNAs that target RABEP2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RABEP2 Gene

Localization for RABEP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RABEP2 Gene

Cytoplasm. Early endosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RABEP2 Gene COMPARTMENTS Subcellular localization image for RABEP2 gene
Compartment Confidence
endosome 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for RABEP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005737 cytoplasm IDA --
GO:0005768 endosome --
GO:0005769 early endosome IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with RABEP2: view

Pathways for RABEP2 Gene

SuperPathways for RABEP2 Gene

No Data Available

Interacting Proteins for RABEP2 Gene

Gene Ontology (GO) - Biological Process for RABEP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0015031 protein transport IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RABEP2: view

No data available for Pathways by source for RABEP2 Gene

Compounds for RABEP2 Gene

(1) HMDB Compounds for RABEP2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(4) Novoseek inferred chemical compound relationships for RABEP2 Gene

Compound -log(P) Hits PubMed IDs
haloperidol 35.7 1
dopamine 17.4 4
cocaine 10.9 3
estrogen 7.91 2
genes like me logo Genes that share compounds with RABEP2: view

Transcripts for RABEP2 Gene

Unigene Clusters for RABEP2 Gene

Rabaptin, RAB GTPase binding effector protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RABEP2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^
SP1: - - - - - - - - - -
SP2: - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: - - - - - -
SP10:
SP11: - - - -
SP12: - - -
SP13: -
SP14: -
SP15:
SP16: - -

ExUns: 15 ^ 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for RABEP2 Gene

GeneLoc Exon Structure for
RABEP2
ECgene alternative splicing isoforms for
RABEP2

Expression for RABEP2 Gene

mRNA expression in normal human tissues for RABEP2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RABEP2 Gene

SOURCE GeneReport for Unigene cluster for RABEP2 Gene Hs.555978

genes like me logo Genes that share expressions with RABEP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RABEP2 Gene

Orthologs for RABEP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RABEP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RABEP2 35
  • 99.29 (n)
  • 98.41 (a)
RABEP2 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RABEP2 35
  • 89.17 (n)
  • 89.95 (a)
RABEP2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RABEP2 35
  • 88.79 (n)
  • 91.19 (a)
RABEP2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rabep2 35
  • 83.03 (n)
  • 85.27 (a)
Rabep2 16
Rabep2 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RABEP2 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RABEP2 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rabep2 35
  • 82.3 (n)
  • 84.91 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
OneToMany
-- 36
  • 37 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.1350 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19157 35
zebrafish
(Danio rerio)
Actinopterygii rabep2 36
  • 36 (a)
OneToOne
Species with no ortholog for RABEP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RABEP2 Gene

ENSEMBL:
Gene Tree for RABEP2 (if available)
TreeFam:
Gene Tree for RABEP2 (if available)

Paralogs for RABEP2 Gene

No data available for Paralogs for RABEP2 Gene

Variants for RABEP2 Gene

Sequence variations from dbSNP and Humsavar for RABEP2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs3924376 -- 28,914,657(+) CCCCC(C/T)GGCCG intron-variant
rs4072401 -- 28,925,954(-) GGTTC(C/T)TGGCG upstream-variant-2KB
rs4072402 -- 28,925,938(-) TTTAC(A/G)GAGGG upstream-variant-2KB
rs4072403 -- 28,926,110(-) GAGTC(C/G)ACact upstream-variant-2KB
rs4072997 -- 28,905,054(+) CGGAT(C/T)GGACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RABEP2 Gene

Variant ID Type Subtype PubMed ID
dgv842e1 CNV Complex 17122850
nsv905700 CNV Loss 21882294
nsv905701 CNV Loss 21882294
nsv905702 CNV Gain+Loss 21882294
nsv518648 CNV Loss 19592680
nsv519100 CNV Gain 19592680
nsv513449 CNV Insertion 21212237
esv2443571 CNV Insertion 19546169

Relevant External Links for RABEP2 Gene

HapMap Linkage Disequilibrium report
RABEP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RABEP2 Gene

Disorders for RABEP2 Gene

(1) MalaCards Diseases for RABEP2 Gene

Search for RABEP2 Gene in MalaCards »
genes like me logo Genes that share disorders with RABEP2: view

No data available for UniProtKB/Swiss-Prot for RABEP2 Gene

Publications for RABEP2 Gene

  1. Two distinct effectors of the small GTPase Rab5 cooperate in endocytic membrane fusion. (PMID: 9524116) Gournier H. … Zerial M. (EMBO J. 1998) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The role of proline-rich protein tyrosine kinase 2 in differentiation-dependent signaling in human epidermal keratinocytes. (PMID: 17205062) Schindler E.M. … Efimova T. (J. Invest. Dermatol. 2007) 3
  5. FRA-1 protein overexpression is a feature of hyperplastic and neoplastic breast disorders. (PMID: 17254320) Chiappetta G. … Fusco A. (BMC Cancer 2007) 3

Products for RABEP2 Gene

  • antibodies-online proteins for RABEP2
  • antibodies-online antibodies for RABEP2
  • antibodies-online kits for RABEP2

Sources for RABEP2 Gene

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