Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RABAC1 Gene

Aliases for RABAC1 Gene

  • Rab Acceptor 1 2 3 5
  • Rab Acceptor 1 (Prenylated) 2 3
  • Prenylated Rab Acceptor 1 2 3
  • PRA1 Family Protein 1 3 4
  • PRA1 Domain Family 1 2 3
  • PRAF1 3 4
  • PRA1 3 4
  • Prenylated Rab Acceptor Protein 1 3
  • YIP3 3

External Ids for RABAC1 Gene

Previous GeneCards Identifiers for RABAC1 Gene

  • GC19M043100
  • GC19M042852
  • GC19M047136
  • GC19M047152
  • GC19M042460
  • GC19M038891

Summaries for RABAC1 Gene

GeneCards Summary for RABAC1 Gene

RABAC1 (Rab Acceptor 1) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and proline-rich region binding.

UniProtKB/Swiss-Prot for RABAC1 Gene

  • General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI.

Gene Wiki entry for RABAC1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RABAC1 Gene

Genomics for RABAC1 Gene

Regulatory Elements for RABAC1 Gene

Enhancers for RABAC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G041937 1.6 FANTOM5 Ensembl ENCODE 31.8 +19.7 19671 4.3 HDGF PKNOX1 FOXA2 CREB3L1 ZNF133 ARID4B DMAP1 ZNF48 YY1 GLIS2 RABAC1 CD79A ARHGEF1 POU2F2 LOC100505585
GH19G041957 1.4 ENCODE dbSUPER 31.6 +0.8 756 2.9 HDGF PKNOX1 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF526 RABAC1 RPS19 CCDC97 MEGF8 CD79A ATP1A3 ZNF574 ERF TMEM145
GH19G041928 1.1 ENCODE 31.4 +30.4 30422 1.5 HDGF FOXA2 CREB3L1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 RABAC1 ZNF526 MEGF8 LOC100505585
GH19G041867 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.3 +85.5 85476 12.3 HDGF PKNOX1 AGO1 WRNIP1 SIN3A ZNF2 ZNF143 PAF1 ZNF263 SP3 ARHGEF1 CD79A RABAC1 POU2F2 DEDD2 CEACAM4 CEACAM21 CEACAM3 ZNF574 MIR6797
GH19G041859 1.2 ENCODE 19.1 +97.4 97382 5.9 CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D RABAC1 ZNF574 CIC PIR51753 MIR6797
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RABAC1 on UCSC Golden Path with GeneCards custom track

Promoters for RABAC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109735 90 1400 PKNOX1 CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF302 ZNF143

Genomic Location for RABAC1 Gene

Chromosome:
19
Start:
41,956,681 bp from pter
End:
41,959,390 bp from pter
Size:
2,710 bases
Orientation:
Minus strand

Genomic View for RABAC1 Gene

Genes around RABAC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RABAC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RABAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RABAC1 Gene

Proteins for RABAC1 Gene

  • Protein details for RABAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UI14-PRAF1_HUMAN
    Recommended name:
    Prenylated Rab acceptor protein 1
    Protein Accession:
    Q9UI14
    Secondary Accessions:
    • Q7Z4Y2
    • Q9Y3R1

    Protein attributes for RABAC1 Gene

    Size:
    185 amino acids
    Molecular mass:
    20648 Da
    Quaternary structure:
    • Homodimer. Interacts with VAMP2 (synaptobrevin-2), GDI1, and PCLO (By similarity). Interacts specifically with prenylated Rab proteins; strongly with RAB4B, RAB5A and RAB5C, and weakly with RAB4A, RAB6, RAB7A, RAB17 and RAB22. Interacts with NDRG1.

neXtProt entry for RABAC1 Gene

Post-translational modifications for RABAC1 Gene

  • Ubiquitination at Lys24 and isoforms=118
  • Modification sites at PhosphoSitePlus

Other Protein References for RABAC1 Gene

No data available for DME Specific Peptides for RABAC1 Gene

Domains & Families for RABAC1 Gene

Gene Families for RABAC1 Gene

Protein Domains for RABAC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RABAC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UI14

UniProtKB/Swiss-Prot:

PRAF1_HUMAN :
  • Belongs to the PRA1 family.
Family:
  • Belongs to the PRA1 family.
genes like me logo Genes that share domains with RABAC1: view

Function for RABAC1 Gene

Molecular function for RABAC1 Gene

UniProtKB/Swiss-Prot Function:
General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI.

Gene Ontology (GO) - Molecular Function for RABAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008022 protein C-terminus binding IEA --
GO:0042802 identical protein binding IPI 16169070
GO:0070064 proline-rich region binding IEA --
genes like me logo Genes that share ontologies with RABAC1: view
genes like me logo Genes that share phenotypes with RABAC1: view

Animal Models for RABAC1 Gene

MGI Knock Outs for RABAC1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RABAC1 Gene

Localization for RABAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RABAC1 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasm. Golgi apparatus. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=According to some authors, it is an integral membrane protein, while others showed that it is cytoplasmic and membrane-associated to Golgi and synaptic vesicles. {ECO:0000250 UniProtKB:O35394}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RABAC1 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
peroxisome 2
nucleus 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
endosome 1

Gene Ontology (GO) - Cellular Components for RABAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA --
GO:0008021 synaptic vesicle IEA --
GO:0016020 membrane IEA,IDA 19946888
genes like me logo Genes that share ontologies with RABAC1: view

Pathways & Interactions for RABAC1 Gene

SuperPathways for RABAC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RABAC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RABAC1 Gene

Drugs & Compounds for RABAC1 Gene

No Compound Related Data Available

Transcripts for RABAC1 Gene

Unigene Clusters for RABAC1 Gene

Rab acceptor 1 (prenylated):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RABAC1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: -
SP2: -
SP3: -
SP4: - -
SP5: - -
SP6: -
SP7:

Relevant External Links for RABAC1 Gene

GeneLoc Exon Structure for
RABAC1
ECgene alternative splicing isoforms for
RABAC1

Expression for RABAC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RABAC1 Gene

Protein differential expression in normal tissues from HIPED for RABAC1 Gene

This gene is overexpressed in Stomach (11.7), Oral epithelium (10.4), and Bone (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RABAC1 Gene



Protein tissue co-expression partners for RABAC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RABAC1 Gene:

RABAC1

SOURCE GeneReport for Unigene cluster for RABAC1 Gene:

Hs.11417

mRNA Expression by UniProt/SwissProt for RABAC1 Gene:

Q9UI14-PRAF1_HUMAN
Tissue specificity: Ubiquitous. Strongest expression found in placenta, pituitary gland, kidney, lung and stomach.

Evidence on tissue expression from TISSUES for RABAC1 Gene

  • Nervous system(4.7)
  • Kidney(4.5)
  • Pancreas(4.4)
  • Intestine(2.3)
  • Muscle(2.3)
  • Stomach(2)
genes like me logo Genes that share expression patterns with RABAC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RABAC1 Gene

Orthologs for RABAC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RABAC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RABAC1 34 35
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia RABAC1 34 35
  • 91.17 (n)
cow
(Bos Taurus)
Mammalia RABAC1 34 35
  • 90.63 (n)
mouse
(Mus musculus)
Mammalia Rabac1 34 16 35
  • 89.37 (n)
rat
(Rattus norvegicus)
Mammalia Rabac1 34
  • 87.93 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RABAC1 35
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RABAC1 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rabac1 34
  • 67.03 (n)
Str.10823 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.23872 34
zebrafish
(Danio rerio)
Actinopterygii rabac1 34 35
  • 62.16 (n)
wufe26d12 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003662 34
  • 52.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1418 34 35
  • 49.25 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YIP3 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9753 35
  • 41 (a)
OneToOne
Species where no ortholog for RABAC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RABAC1 Gene

ENSEMBL:
Gene Tree for RABAC1 (if available)
TreeFam:
Gene Tree for RABAC1 (if available)

Paralogs for RABAC1 Gene

No data available for Paralogs for RABAC1 Gene

Variants for RABAC1 Gene

Sequence variations from dbSNP and Humsavar for RABAC1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000236989 -- 41,957,790(+) CATTT(G/T)GTTTT intron-variant
rs1002177196 -- 41,959,159(+) GCTCT(C/G)GAGGG intron-variant
rs1003010239 -- 41,956,247(+) CATTT(C/G)ACACG downstream-variant-500B
rs1003227137 -- 41,960,928(+) CCTGA(C/T)TTTGT upstream-variant-2KB
rs1003584262 -- 41,960,546(+) TGACC(A/T)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RABAC1 Gene

Variant ID Type Subtype PubMed ID
dgv3550n100 CNV gain 25217958
nsv520239 CNV loss 19592680
nsv522854 CNV gain 19592680
nsv953580 CNV deletion 24416366

Variation tolerance for RABAC1 Gene

Residual Variation Intolerance Score: 22.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RABAC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RABAC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RABAC1 Gene

Disorders for RABAC1 Gene

Relevant External Links for RABAC1

Genetic Association Database (GAD)
RABAC1
Human Genome Epidemiology (HuGE) Navigator
RABAC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RABAC1

No disorders were found for RABAC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RABAC1 Gene

Publications for RABAC1 Gene

  1. Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2). (PMID: 16481131) Fo C.S. … Bachmann A.S. (Gene 2006) 3 4 22 64
  2. Expression analysis and chromosomal assignment of PRA1 and RILP genes. (PMID: 11520070) Bucci C. … Bruni C.B. (Biochem. Biophys. Res. Commun. 2001) 3 4 22 64
  3. Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1). (PMID: 10329441) Bucci C. … Bruni C.B. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Prenylated Rab acceptor 1 (PRA1) inhibits TCF/beta-catenin signaling by binding to beta-catenin. (PMID: 16930546) Kim J.T. … Lim J.S. (Biochem. Biophys. Res. Commun. 2006) 3 22 64

Products for RABAC1 Gene

Sources for RABAC1 Gene

Content
Loading form....