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Aliases for RABAC1 Gene

Aliases for RABAC1 Gene

  • Rab Acceptor 1 (Prenylated) 2 3
  • PRA1 3 4 6
  • Prenylated Rab Acceptor 1 2 3
  • PRA1 Family Protein 1 3 4
  • PRA1 Domain Family 1 2 3
  • PRAF1 3 4
  • Prenylated Rab Acceptor Protein 1 3
  • YIP3 3

External Ids for RABAC1 Gene

Previous GeneCards Identifiers for RABAC1 Gene

  • GC19M043100
  • GC19M042852
  • GC19M047136
  • GC19M047152
  • GC19M042460
  • GC19M038891

Summaries for RABAC1 Gene

GeneCards Summary for RABAC1 Gene

RABAC1 (Rab Acceptor 1 (Prenylated)) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and proline-rich region binding.

UniProtKB/Swiss-Prot for RABAC1 Gene

  • General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI (By similarity).

Gene Wiki entry for RABAC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RABAC1 Gene

Genomics for RABAC1 Gene

Regulatory Elements for RABAC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RABAC1 Gene

Start:
41,956,681 bp from pter
End:
41,959,390 bp from pter
Size:
2,710 bases
Orientation:
Minus strand

Genomic View for RABAC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RABAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RABAC1 Gene

Proteins for RABAC1 Gene

  • Protein details for RABAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UI14-PRAF1_HUMAN
    Recommended name:
    Prenylated Rab acceptor protein 1
    Protein Accession:
    Q9UI14
    Secondary Accessions:
    • Q7Z4Y2
    • Q9Y3R1

    Protein attributes for RABAC1 Gene

    Size:
    185 amino acids
    Molecular mass:
    20648 Da
    Quaternary structure:
    • Homodimer. Interacts with VAMP2 (synaptobrevin-2), GDI1, and PCLO (By similarity). Interacts specifically with prenylated Rab proteins; strongly with RAB4B, RAB5A and RAB5C, and weakly with RAB4A, RAB6, RAB7A, RAB17 and RAB22. Interacts with NDRG1.

neXtProt entry for RABAC1 Gene

Proteomics data for RABAC1 Gene at MOPED

Post-translational modifications for RABAC1 Gene

  • Ubiquitination at Lys9, Lys24, and Lys118
  • Modification sites at PhosphoSitePlus

Other Protein References for RABAC1 Gene

No data available for DME Specific Peptides for RABAC1 Gene

Domains for RABAC1 Gene

Protein Domains for RABAC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RABAC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UI14

UniProtKB/Swiss-Prot:

PRAF1_HUMAN :
  • Q9UI14
Family:
  • Belongs to the PRA1 family.
genes like me logo Genes that share domains with RABAC1: view

No data available for Gene Families for RABAC1 Gene

Function for RABAC1 Gene

Molecular function for RABAC1 Gene

UniProtKB/Swiss-Prot Function: General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI (By similarity).

Gene Ontology (GO) - Molecular Function for RABAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008022 protein C-terminus binding IEA --
GO:0042802 identical protein binding IPI 16169070
GO:0070064 proline-rich region binding IEA --
genes like me logo Genes that share ontologies with RABAC1: view

Phenotypes for RABAC1 Gene

GenomeRNAi human phenotypes for RABAC1:
genes like me logo Genes that share phenotypes with RABAC1: view

Animal Model Products

CRISPR Products

miRNA for RABAC1 Gene

miRTarBase miRNAs that target RABAC1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RABAC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RABAC1 Gene

Localization for RABAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RABAC1 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasm. Golgi apparatus. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=According to some authors, it is an integral membrane protein, while others showed that it is cytoplasmic and membrane-associated to Golgi and synaptic vesicles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RABAC1 Gene COMPARTMENTS Subcellular localization image for RABAC1 gene
Compartment Confidence
plasma membrane 5
cytosol 2
golgi apparatus 2
nucleus 2
peroxisome 2
endoplasmic reticulum 1
endosome 1
extracellular 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RABAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA --
GO:0008021 synaptic vesicle IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RABAC1: view

Pathways for RABAC1 Gene

SuperPathways for RABAC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RABAC1 Gene

None

No data available for Pathways by source for RABAC1 Gene

Transcripts for RABAC1 Gene

Unigene Clusters for RABAC1 Gene

Rab acceptor 1 (prenylated):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RABAC1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RABAC1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: -
SP2: -
SP3: -
SP4: - -
SP5: - -
SP6: -
SP7:

Relevant External Links for RABAC1 Gene

GeneLoc Exon Structure for
RABAC1
ECgene alternative splicing isoforms for
RABAC1

Expression for RABAC1 Gene

mRNA expression in normal human tissues for RABAC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RABAC1 Gene

SOURCE GeneReport for Unigene cluster for RABAC1 Gene Hs.11417

mRNA Expression by UniProt/SwissProt for RABAC1 Gene

Q9UI14-PRAF1_HUMAN
Tissue specificity: Ubiquitous. Strongest expression found in placenta, pituitary gland, kidney, lung and stomach.
genes like me logo Genes that share expressions with RABAC1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RABAC1 Gene

Orthologs for RABAC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RABAC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RABAC1 35
  • 99.46 (n)
  • 98.91 (a)
RABAC1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RABAC1 35
  • 90.63 (n)
  • 93.51 (a)
RABAC1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RABAC1 35
  • 91.17 (n)
  • 94.59 (a)
RABAC1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rabac1 35
  • 89.37 (n)
  • 94.59 (a)
Rabac1 16
Rabac1 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RABAC1 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rabac1 35
  • 87.93 (n)
  • 95.14 (a)
lizard
(Anolis carolinensis)
Reptilia RABAC1 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23872 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rabac1 35
  • 67.03 (n)
  • 69.02 (a)
Str.10823 35
zebrafish
(Danio rerio)
Actinopterygii rabac1 35
  • 62.16 (n)
  • 62.16 (a)
rabac1 36
  • 60 (a)
OneToOne
wufe26d12 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003662 35
  • 52.35 (n)
  • 42.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1418 35
  • 49.25 (n)
  • 37.42 (a)
CG1418 36
  • 31 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YIP3 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9753 36
  • 41 (a)
OneToOne
Species with no ortholog for RABAC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RABAC1 Gene

ENSEMBL:
Gene Tree for RABAC1 (if available)
TreeFam:
Gene Tree for RABAC1 (if available)

Paralogs for RABAC1 Gene

No data available for Paralogs for RABAC1 Gene

Variants for RABAC1 Gene

Sequence variations from dbSNP and Humsavar for RABAC1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs10182 -- 41,956,852(+) CACAC(A/G)GGTTC reference, synonymous-codon
rs13493 -- 41,958,293(+) AAGAG(C/G)ACAAG synonymous-codon, reference
rs15013 -- 41,956,880(+) CGTCC(A/T)CAGCC missense, reference
rs735571 -- 41,959,295(-) ACGCA(A/G)ACATG utr-variant-5-prime
rs1044689 -- 41,956,774(-) CGGCT(C/T)TGCTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RABAC1 Gene

Variant ID Type Subtype PubMed ID
nsv522854 CNV Gain 19592680
dgv3882n71 CNV Loss 21882294
dgv3883n71 CNV Loss 21882294
nsv520239 CNV Loss 19592680

Relevant External Links for RABAC1 Gene

HapMap Linkage Disequilibrium report
RABAC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RABAC1 Gene

Disorders for RABAC1 Gene

Relevant External Links for RABAC1

Genetic Association Database (GAD)
RABAC1
Human Genome Epidemiology (HuGE) Navigator
RABAC1
genes like me logo Genes that share disorders with RABAC1: view

No data available for UniProtKB/Swiss-Prot for RABAC1 Gene

Publications for RABAC1 Gene

  1. Expression analysis and chromosomal assignment of PRA1 and RILP genes. (PMID: 11520070) Bucci C. … Bruni C.B. (Biochem. Biophys. Res. Commun. 2001) 3 4 23
  2. Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2). (PMID: 16481131) Fo C.S. … Bachmann A.S. (Gene 2006) 3 4 23
  3. Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1). (PMID: 10329441) Bucci C. … Bruni C.B. (Biochem. Biophys. Res. Commun. 1999) 2 3 4
  4. PRA1 inhibits the extraction of membrane-bound rab GTPase by GDI1. (PMID: 10751420) Hutt D.M. … Ngsee J.K. (J. Biol. Chem. 2000) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RABAC1 Gene

  • antibodies-online proteins for RABAC1
  • antibodies-online antibodies for RABAC1
  • antibodies-online kits for RABAC1

Sources for RABAC1 Gene

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