Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RABAC1 Gene

protein-coding   GIFtS: 56
GCID: GC19M042460

Rab Acceptor 1 (Prenylated)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Rab Acceptor 1 (Prenylated)1 2     PRAF12 3
PRA12 3 5     PRA1 Family Protein 12 3
PRA1 Domain Family 11 2     YIP32
Prenylated Rab Acceptor 11 2     Prenylated Rab Acceptor Protein 12

External Ids:    HGNC: 97941   Entrez Gene: 105672   Ensembl: ENSG000001054047   OMIM: 6049255   UniProtKB: Q9UI143   
ORGUL members:         

Export aliases for RABAC1 gene to outside databases

Previous GC identifers: GC19M043100 GC19M042852 GC19M047136 GC19M047152 GC19M038891


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for RABAC1 Gene:
RABAC1 (Rab acceptor 1 (prenylated)) is a protein-coding gene. Diseases associated with RABAC1 include candidiasis, and endometrial carcinoma. GO annotations related to this gene include proline-rich region binding and identical protein binding.

UniProtKB/Swiss-Prot: PRAF1_HUMAN, Q9UI14
Function: General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle
docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the
removal of Rab GTPases from the membrane by GDI (By similarity)

Gene Wiki entry for RABAC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the RABAC1 gene promoter:
         Pax-5   p300   MIF-1   NF-kappaB   GATA-2   SEF-1 (1)   NF-kappaB1   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRABAC1 promoter sequence
   Search Chromatin IP Primers for RABAC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RABAC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

RABAC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RABAC1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M042460:  view genomic region     (about GC identifiers)

Start:
42,460,833 bp from pter      End:
42,463,542 bp from pter
Size:
2,710 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PRAF1_HUMAN, Q9UI14 (See protein sequence)
Recommended Name: Prenylated Rab acceptor protein 1  
Size: 185 amino acids; 20648 Da
Subunit: Homodimer. Interacts with VAMP2 (synaptobrevin-2), GDI1, and PCLO (By similarity). Interacts specifically
with prenylated Rab proteins; strongly with RAB4B, RAB5A and RAB5C, and weakly with RAB4A, RAB6, RAB7A, RAB17 and
RAB22. Interacts with NDRG1
Developmental stage: In fetal tissues, it is more abundant in kidney and lung
Caution: In contrast to the mouse ortholog, it does not interact with Ras
Secondary accessions: Q7Z4Y2 Q9Y3R1

Explore the universe of human proteins at neXtProt for RABAC1: NX_Q9UI14

Explore proteomics data for RABAC1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys9, Lys24, Lys118
  • Modification sites at PhosphoSitePlus

  • See RABAC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006414.2  
    ENSEMBL proteins: 
     ENSP00000471877   ENSP00000473152   ENSP00000222008   ENSP00000469161   ENSP00000469392  

    RABAC1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RABAC1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RABAC1
    GenScript Custom Purified and Recombinant Proteins Services for RABAC1
    Novus Biologicals RABAC1 Proteins
    Novus Biologicals RABAC1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RABAC1

    RABAC1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RABAC1
    OriGene Custom Antibody Services for RABAC1
    Novus Biologicals RABAC1 Antibodies
    Abcam antibodies for RABAC1
    Cloud-Clone Corp. Antibodies for RABAC1
    ThermoFisher Antibody for RABAC1
    LSBio Antibodies in human, mouse, rat for RABAC1

    RABAC1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RABAC1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RABAC1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RABAC1
    Cloud-Clone Corp. CLIAs for RABAC1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR004895 Prenylated_rab_accept_PRA1

    Graphical View of Domain Structure for InterPro Entry Q9UI14

    ProtoNet protein and cluster: Q9UI14

    UniProtKB/Swiss-Prot: PRAF1_HUMAN, Q9UI14
    Similarity: Belongs to the PRA1 family


    RABAC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRAF1_HUMAN, Q9UI14
    Function: General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle
    docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the
    removal of Rab GTPases from the membrane by GDI (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0008022protein C-terminus binding IEA--
    GO:0042802identical protein binding IPI16169070
    GO:0070064proline-rich region binding IEA--
         
    RABAC1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RABAC1:
     Increased G2M DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RABAC1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RABAC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RABAC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RABAC1

    miRNA
    Products:
        
    miRTarBase miRNAs that target RABAC1:
    hsa-mir-423-5p (MIRT038011), hsa-mir-18a-5p (MIRT050705)

    Block miRNA regulation of human, mouse, rat RABAC1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RABAC1
    SwitchGear 3'UTR luciferase reporter plasmidRABAC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RABAC1
    Predesigned siRNA for gene silencing in human, mouse, rat RABAC1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RABAC1

    Clone
    Products:
         
    OriGene clones in human, mouse for RABAC1 (see all 6)
    OriGene ORF clones in mouse, rat for RABAC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RABAC1 (NM_006423)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RABAC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RABAC1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RABAC1
    Browse ESI BIO Cell Lines and PureStem Progenitors for RABAC1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RABAC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PRAF1_HUMAN, Q9UI14: Cell membrane; Multi-pass membrane protein (By similarity). Cytoplasm (By similarity). Golgi
    apparatus (By similarity). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle (By similarity).
    Note=According to some authors, it is an integral membrane protein, while others showed that it is cytoplasmic
    and membrane-associated to Golgi and synaptic vesicles (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol2
    golgi apparatus2
    nucleus2
    peroxisome2
    endoplasmic reticulum1
    endosome1
    extracellular1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IEA--
    GO:0005886plasma membrane IEA--
    GO:0008021synaptic vesicle IEA--
    GO:0016021integral component of membrane IEA--
    GO:0030054cell junction IEA--

    RABAC1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RABAC1
    Interactions:

        GeneGlobe Interaction Network for RABAC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RABAC1 (Q9UI141, 2, 3 ENSP000002220084) via UniProtKB, MINT, STRING, and/or I2D (see all 140)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LMP1P032301, 2EBI-712367,EBI-6973030 MINT-2982263 MINT-2982440 MINT-2982340 MINT-2982392 MINT-2982416 MINT-2982313 MINT-2982365 MINT-2982212 MINT-2982239
    FXR2P511161, 2, 3, ENSP000002501134EBI-712367,EBI-740459 MINT-66878 I2D: score=5 STRING: ENSP00000250113
    PLEKHF2Q9H8W41, 2, 3, ENSP000003223734EBI-712367,EBI-742388 MINT-67621 I2D: score=5 STRING: ENSP00000322373
    RABAC1Q9UI141, 2EBI-712367,EBI-712367 MINT-8267797 MINT-67868 MINT-65746
    ADCK3Q8NI602, 3, ENSP000003557394MINT-66678 I2D: score=5 STRING: ENSP00000355739
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RABAC1 (PRAF1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RABAC1 gene: 
    NM_006423.2  

    Unigene Cluster for RABAC1:

    Rab acceptor 1 (prenylated)
    Hs.11417  [show with all ESTs]
    Unigene Representative Sequence: BM474950
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000598057 ENST00000600292 ENST00000601891 ENST00000222008(uc002osf.3)
    ENST00000601028 ENST00000595226 ENST00000601078 ENST00000596171 ENST00000601476
    ENST00000599219
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RABAC1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RABAC1
    SwitchGear 3'UTR luciferase reporter plasmidRABAC1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RABAC1
    Predesigned siRNA for gene silencing in human, mouse, rat RABAC1
    Clone
    Products:
         
    OriGene clones in human, mouse for RABAC1 (see all 6)
    OriGene ORF clones in mouse, rat for RABAC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RABAC1 (NM_006423)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RABAC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RABAC1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RABAC1
    OriGene qSTAR qPCR primer pairs in human, mouse for RABAC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RABAC1
      QuantiTect SYBR Green Assays in human, mouse, rat RABAC1
      QuantiFast Probe-based Assays in human, mouse, rat RABAC1

    Additional mRNA sequence: 

    AF112202.1 AF112996.1 AJ133534.1 BC008950.2 BT019964.1 CR457214.1 CR542116.1 

    10 DOTS entries:

    DT.444231  DT.97838416  DT.92059196  DT.97838349  DT.95214543  DT.100058843  DT.92434407  DT.92434410 
    DT.100059290  DT.95214563 

    Selected AceView cDNA sequences (see all 390):

    BX089459 BU787402 CR542116 BU727397 BQ063454 CA309402 CF242972 BQ613843 
    BQ061589 BM973549 AI916505 BQ225284 AI341845 CA413990 BQ613743 BM771894 
    CN485264 BM771350 CF127314 BX377961 AI141717 BM770954 BQ059671 CA310333 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RABAC1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
    SP1:                          -                                                   
    SP2:                          -                                                   
    SP3:                          -                                                   
    SP4:                          -                       -                           
    SP5:                          -                 -                                 


    ECgene alternative splicing isoforms for RABAC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RABAC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGTCCTGC
    RABAC1 Expression
    About this image


    RABAC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    RABAC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RABAC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.11417

    UniProtKB/Swiss-Prot: PRAF1_HUMAN, Q9UI14
    Tissue specificity: Ubiquitous. Strongest expression found in placenta, pituitary gland, kidney, lung and stomach

        Custom PCR Arrays for RABAC1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RABAC1
    OriGene qSTAR qPCR primer pairs in human, mouse for RABAC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RABAC1
    QuantiTect SYBR Green Assays in human, mouse, rat RABAC1
    QuantiFast Probe-based Assays in human, mouse, rat RABAC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RABAC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for RABAC1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rabac11 , 5 Rab acceptor 1 (prenylated)1, 5 89.37(n)1
    94.59(a)1
      7 (13.73 cM)5
    144701  NM_010261.21  NP_034391.11 
     249697505 
    lizard
    (Anolis carolinensis)
    Reptilia RABAC16
    Rab acceptor 1 (prenylated)
    79(a)
    1 ↔ 1
    GL344515.1(12937-16782)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.238722 Xenopus laevis transcribed sequence with weak similarity more 73.21(n)    CA981966.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufe26d122 Danio rerio Rab acceptor 1 (prenylated) (RABAC1) mRNA, more 70.91(n)    AY391453.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG14181 CG1418 49.25(n)
    37.42(a)
      36035  NM_136695.2  NP_610539.1 


    ENSEMBL Gene Tree for RABAC1 (if available)
    TreeFam Gene Tree for RABAC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RABAC1 (see all 128)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1889380201,2
    --42460342(+) TGGCCA/GCCCCC 1 -- int10--------
    rs1916380761,2
    --42460362(+) AGGGCA/GCTGAG 1 -- int10--------
    rs1834903731,2
    --42460391(+) CTGGCC/TGACAT 1 -- int10--------
    rs1879831991,2
    --42460500(+) GCTGAC/TTTGGC 1 -- int10--------
    rs1171995511,2
    C,F--42460653(+) CCCCCG/AGCACA 1 -- int11Minor allele frequency- A:0.03NA 120
    rs1403042131,2
    --42460781(+) GCTCTA/GTGCAG 1 -- int10--------
    rs785533241,2
    F--42460783(+) TCTGTG/ACAGTA 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1133811101,2
    C,F--42460852(+) CACCCG/ATAACA 1 -- ut311Minor allele frequency- A:0.50CSA 2
    rs2002694951,2
    C--42460977(+) GAGGCC/TGGCAG 1 -- ut310--------
    rs1997751811,2
    --42460990(+) CCCAGA/CAGACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RABAC1 (42460833 - 42463542 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RABAC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv520239CNV Loss19592680
    dgv3883n71CNV Loss21882294
    dgv3882n71CNV Loss21882294
    nsv522854CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RABAC1
    DNA2.0 Custom Variant and Variant Library Synthesis for RABAC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604925    OMIM disorders: --

    4 diseases for RABAC1:    
    About MalaCards
    candidiasis    endometrial carcinoma    hypoxia    malaria


    RABAC1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RABAC1
    Human Genome Epidemiology (HuGE) Navigator: RABAC1 (3 documents)

    Export disorders for RABAC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RABAC1 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with RABAC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1). (PubMed id 10329441)1, 2, 3 Bucci C.... Bruni C.B. (Biochem. Biophys. Res. Commun. 1999)
    2. Expression analysis and chromosomal assignment of PRA1 and RILP genes. (PubMed id 11520070)1, 2, 9 Bucci C.... Bruni C.B. (Biochem. Biophys. Res. Commun. 2001)
    3. Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2). (PubMed id 16481131)1, 2, 9 Fo C.S.... Bachmann A.S. (Gene 2006)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. PRA1 inhibits the extraction of membrane-bound rab GTPase by GDI1. (PubMed id 10751420)1, 3 Hutt D.M....Ngsee J.K. (J. Biol. Chem. 2000)
    7. Prenylated Rab acceptor 1 (PRA1) inhibits TCF/beta-catenin signaling by binding to beta-catenin. (PubMed id 16930546)1, 9 Kim J.T....Lim J.S. (Biochem. Biophys. Res. Commun. 2006)
    8. PRA1 co-localizes with envelope but does not influence primate lentivirus production, infectivity or envelope incorporation. (PubMed id 15914857)1, 9 Blancou P....Desrosiers R.C. (J. Gen. Virol. 2005)
    9. Pitfalls in the use of transfected overexpression systems to study membrane proteins function: the case of TSH receptor and PRA1. (PubMed id 14604818)1, 9 Jacobs C. and Pirson I. (Mol. Cell. Endocrinol. 2003)
    10. Yip3 catalyses the dissociation of endosomal Rab-GDI complexes. (PubMed id 14574414)1, 9 Sivars U....Pfeffer S.R. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10567 HGNC: 9794 AceView: RABAC1 Ensembl:ENSG00000105404 euGenes: HUgn10567
    ECgene: RABAC1 H-InvDB: RABAC1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RABAC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RABAC1 gene:
    Search GeneIP for patents involving RABAC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RABAC1   OriGene RNAi products in human, mouse, rat for RABAC1  
     OriGene qPCR primer pairs and template standards for RABAC1   OriGene Protein Over-expression Lysate for RABAC1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RABAC1  
     OriGene qSTAR qPCR primer pairs in human, mouse for RABAC1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RABAC1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RABAC1   OriGene Custom Protein Services for RABAC1  

     
     
     Block miRNA regulation of human, mouse, rat RABAC1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RABAC1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RABAC1 Predesigned siRNA for gene silencing in human, mouse, rat RABAC1
     QuantiFast Probe-based Assays in human, mouse, rat RABAC1 QuantiTect SYBR Green Assays in human, mouse, rat RABAC1
     Custom PCR Arrays for RABAC1 Search Chromatin IP Primers for RABAC1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RABAC1  GeneGlobe Interaction Network for RABAC1
     Regulatory tfbs in RABAC1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RABAC1 GenScript cDNA clones with any tag delivered in your preferred vector for RABAC1
     GenScript Custom Assay Services for RABAC1 GenScript Custom overexpressing Cell Line Services for RABAC1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RABAC1 (PRAF1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RABAC1 antibodies
     RABAC1 proteins
     RABAC1 lysates
     Antibodies for RABAC1
     See all of Abcam's Antibodies, Kits and Proteins for RABAC1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RABAC1
     Antibodies for RABAC1
     ELISAs for RABAC1
     CLIAs for RABAC1



     Browse ESI BIO Cell Lines and PureStem Progenitors for RABAC1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RABAC1
     SwitchGear 3'UTR luciferase reporter plasmids for RABAC1
     SwitchGear Promoter luciferase reporter plasmids for RABAC1
     ThermoFisher Antibody for RABAC1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RABAC1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RABAC1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RABAC1
     LSBio Antibodies in human, mouse, rat for RABAC1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RABAC1 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4