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Aliases for RABAC1 Gene

Aliases for RABAC1 Gene

  • Rab Acceptor 1 2 3
  • Rab Acceptor 1 (Prenylated) 2 3 5
  • Prenylated Rab Acceptor 1 2 3
  • PRA1 Family Protein 1 3 4
  • PRA1 Domain Family 1 2 3
  • PRAF1 3 4
  • PRA1 3 4
  • YIP3 3

External Ids for RABAC1 Gene

Previous GeneCards Identifiers for RABAC1 Gene

  • GC19M043100
  • GC19M042852
  • GC19M047136
  • GC19M047152
  • GC19M042460
  • GC19M038891

Summaries for RABAC1 Gene

GeneCards Summary for RABAC1 Gene

RABAC1 (Rab Acceptor 1) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and proline-rich region binding.

UniProtKB/Swiss-Prot for RABAC1 Gene

  • General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI.

Gene Wiki entry for RABAC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RABAC1 Gene

Genomics for RABAC1 Gene

Regulatory Elements for RABAC1 Gene

Promoters for RABAC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RABAC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RABAC1 Gene

Chromosome:
19
Start:
41,956,681 bp from pter
End:
41,959,390 bp from pter
Size:
2,710 bases
Orientation:
Minus strand

Genomic View for RABAC1 Gene

Genes around RABAC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RABAC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RABAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RABAC1 Gene

Proteins for RABAC1 Gene

  • Protein details for RABAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UI14-PRAF1_HUMAN
    Recommended name:
    Prenylated Rab acceptor protein 1
    Protein Accession:
    Q9UI14
    Secondary Accessions:
    • Q7Z4Y2
    • Q9Y3R1

    Protein attributes for RABAC1 Gene

    Size:
    185 amino acids
    Molecular mass:
    20648 Da
    Quaternary structure:
    • Homodimer. Interacts with VAMP2 (synaptobrevin-2), GDI1, and PCLO (By similarity). Interacts specifically with prenylated Rab proteins; strongly with RAB4B, RAB5A and RAB5C, and weakly with RAB4A, RAB6, RAB7A, RAB17 and RAB22. Interacts with NDRG1.

neXtProt entry for RABAC1 Gene

Proteomics data for RABAC1 Gene at MOPED

Post-translational modifications for RABAC1 Gene

  • Ubiquitination at Lys 24 and Lys 118
  • Modification sites at PhosphoSitePlus

Other Protein References for RABAC1 Gene

Antibody Products

No data available for DME Specific Peptides for RABAC1 Gene

Domains & Families for RABAC1 Gene

Gene Families for RABAC1 Gene

Protein Domains for RABAC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RABAC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UI14

UniProtKB/Swiss-Prot:

PRAF1_HUMAN :
  • Belongs to the PRA1 family.
Family:
  • Belongs to the PRA1 family.
genes like me logo Genes that share domains with RABAC1: view

Function for RABAC1 Gene

Molecular function for RABAC1 Gene

UniProtKB/Swiss-Prot Function:
General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI.

Gene Ontology (GO) - Molecular Function for RABAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with RABAC1: view
genes like me logo Genes that share phenotypes with RABAC1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RABAC1 Gene

Localization for RABAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RABAC1 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasm. Golgi apparatus. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=According to some authors, it is an integral membrane protein, while others showed that it is cytoplasmic and membrane-associated to Golgi and synaptic vesicles. {ECO:0000250 UniProtKB:O35394}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RABAC1 Gene COMPARTMENTS Subcellular localization image for RABAC1 gene
Compartment Confidence
golgi apparatus 4
plasma membrane 4
nucleus 2
peroxisome 2
cytosol 1
endoplasmic reticulum 1
endosome 1
extracellular 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RABAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0008021 synaptic vesicle IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with RABAC1: view

Pathways & Interactions for RABAC1 Gene

SuperPathways for RABAC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RABAC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RABAC1 Gene

Drugs & Compounds for RABAC1 Gene

No Compound Related Data Available

Transcripts for RABAC1 Gene

Unigene Clusters for RABAC1 Gene

Rab acceptor 1 (prenylated):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RABAC1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: -
SP2: -
SP3: -
SP4: - -
SP5: - -
SP6: -
SP7:

Relevant External Links for RABAC1 Gene

GeneLoc Exon Structure for
RABAC1
ECgene alternative splicing isoforms for
RABAC1

Expression for RABAC1 Gene

mRNA expression in normal human tissues for RABAC1 Gene

Protein differential expression in normal tissues from HIPED for RABAC1 Gene

This gene is overexpressed in Stomach (11.7), Oral epithelium (10.4), and Bone (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RABAC1 Gene



SOURCE GeneReport for Unigene cluster for RABAC1 Gene Hs.11417

mRNA Expression by UniProt/SwissProt for RABAC1 Gene

Q9UI14-PRAF1_HUMAN
Tissue specificity: Ubiquitous. Strongest expression found in placenta, pituitary gland, kidney, lung and stomach.
genes like me logo Genes that share expression patterns with RABAC1: view

Protein tissue co-expression partners for RABAC1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RABAC1 Gene

Orthologs for RABAC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RABAC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RABAC1 36
  • 99 (a)
OneToOne
RABAC1 35
  • 99.46 (n)
  • 98.91 (a)
cow
(Bos Taurus)
Mammalia RABAC1 35
  • 90.63 (n)
  • 93.51 (a)
RABAC1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RABAC1 36
  • 95 (a)
OneToOne
RABAC1 35
  • 91.17 (n)
  • 94.59 (a)
mouse
(Mus musculus)
Mammalia Rabac1 36
  • 95 (a)
OneToOne
Rabac1 16
Rabac1 35
  • 89.37 (n)
  • 94.59 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia RABAC1 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rabac1 35
  • 87.93 (n)
  • 95.14 (a)
lizard
(Anolis carolinensis)
Reptilia RABAC1 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23872 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rabac1 35
  • 67.03 (n)
  • 69.02 (a)
Str.10823 35
zebrafish
(Danio rerio)
Actinopterygii rabac1 35
  • 62.16 (n)
  • 62.16 (a)
wufe26d12 35
rabac1 36
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003662 35
  • 52.35 (n)
  • 42.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1418 35
  • 49.25 (n)
  • 37.42 (a)
CG1418 36
  • 31 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YIP3 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9753 36
  • 41 (a)
OneToOne
Species with no ortholog for RABAC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RABAC1 Gene

ENSEMBL:
Gene Tree for RABAC1 (if available)
TreeFam:
Gene Tree for RABAC1 (if available)

Paralogs for RABAC1 Gene

No data available for Paralogs for RABAC1 Gene

Variants for RABAC1 Gene

Sequence variations from dbSNP and Humsavar for RABAC1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10182 -- 41,956,852(+) CACAC(A/C/G)GGTTC reference, synonymous-codon
rs13493 -- 41,958,293(+) AAGAG(C/G/T)ACAAG reference, synonymous-codon
rs735571 -- 41,959,295(-) ACGCA(A/G)ACATG utr-variant-5-prime
rs55960841 -- 41,956,997(+) CCCAG(A/C)TGCTC intron-variant
rs80101175 -- 41,958,623(+) AAGAG(A/G)GCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RABAC1 Gene

Variant ID Type Subtype PubMed ID
nsv522854 CNV Gain 19592680
dgv3882n71 CNV Loss 21882294
dgv3883n71 CNV Loss 21882294
nsv520239 CNV Loss 19592680

Variation tolerance for RABAC1 Gene

Residual Variation Intolerance Score: 22.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RABAC1 Gene

HapMap Linkage Disequilibrium report
RABAC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RABAC1 Gene

Disorders for RABAC1 Gene

Relevant External Links for RABAC1

Genetic Association Database (GAD)
RABAC1
Human Genome Epidemiology (HuGE) Navigator
RABAC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RABAC1

No disorders were found for RABAC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RABAC1 Gene

Publications for RABAC1 Gene

  1. Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1). (PMID: 10329441) Bucci C. … Bruni C.B. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 67
  2. Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2). (PMID: 16481131) Fo C.S. … Bachmann A.S. (Gene 2006) 3 23
  3. Prenylated Rab acceptor 1 (PRA1) inhibits TCF/beta-catenin signaling by binding to beta-catenin. (PMID: 16930546) Kim J.T. … Lim J.S. (Biochem. Biophys. Res. Commun. 2006) 3 23
  4. PRA1 co-localizes with envelope but does not influence primate lentivirus production, infectivity or envelope incorporation. (PMID: 15914857) Blancou P. … Desrosiers R.C. (J. Gen. Virol. 2005) 3 23
  5. Pitfalls in the use of transfected overexpression systems to study membrane proteins function: the case of TSH receptor and PRA1. (PMID: 14604818) Jacobs C. … Pirson I. (Mol. Cell. Endocrinol. 2003) 3 23

Products for RABAC1 Gene

Sources for RABAC1 Gene

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