RABAC1 Gene
protein-coding GIFtS: 51
GCID: GC19M042460
|
|
Rab acceptor 1 (prenylated)
| |
Aliases
for RABAC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Rab Acceptor 1 (Prenylated)1 2 | | PRA1 Family Protein 12 3 | | PRA11 2 3 5 | | PRA1 Domain Family 12 | | PRAF11 2 3 | | Prenylated Rab Acceptor 12 | | YIP31 2 | | Prenylated Rab Acceptor Protein 12 |
Export aliases for RABAC1 gene to outside databasesPrevious GC identifers: GC19M043100 GC19M042852 GC19M047136 GC19M047152 GC19M038891 |
Summaries
for RABAC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PRAF1_HUMAN, Q9UI14Function: General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicledocking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removalof Rab GTPases from the membrane by GDI (By similarity)
Gene Wiki entry for RABAC1
|
Genomic Views
for RABAC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RABAC1 gene promoter:
Pax-5 p300 MIF-1 NF-kappaB GATA-2 SEF-1 (1) NF-kappaB1 TGIF
Other transcription factors
Search SABiosciences Chromatin IP Primers for RABAC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RABAC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2RABAC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M042460: view genomic region
(about GC identifiers)
Start:
|
42,460,833 bp from pter |
End:
|
42,463,528 bp from pter |
Size:
|
2,696 bases |
Orientation:
|
minus strand |
|
Proteins
for RABAC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PRAF1_HUMAN, Q9UI14 (See
protein sequence)Recommended Name: Prenylated Rab acceptor protein 1 Size: 185 amino acids; 20648 Da
Subunit: Homodimer. Interacts with VAMP2 (synaptobrevin-2), GDI1, and PCLO (By similarity). Interacts specifically withprenylated Rab proteins; strongly with RAB4B, RAB5A and RAB5C, and weakly with RAB4A, RAB6, RAB7A, RAB17 and RAB22.Interacts with NDRG1
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity). Cytoplasm (By similarity). Golgiapparatus (By similarity). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle (By similarity). Note=According tosome authors, it is an integral membrane protein, while others showed that it is cytoplasmic and membrane-associatedto Golgi and synaptic vesicles (By similarity)
Developmental stage: In fetal tissues, it is more abundant in kidney and lung
Caution: In contrast to the mouse ortholog, it does not interact with Ras
Secondary accessions: Q7Z4Y2 Q9Y3R1Explore the universe of human proteins at neXtProt for RABAC1: NX_Q9UI14
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UI14
RABAC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006414.2
ENSEMBL proteins: ENSP00000222008
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
RABAC1 for ontologies About GeneDecksing
RABAC1 Antibody Products:
Assay Products for RABAC1: |
Protein
Domains /
Families
for RABAC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RABAC1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UI14ProtoNet protein and cluster: Q9UI14 UniProtKB/Swiss-Prot: PRAF1_HUMAN, Q9UI14Similarity: Belongs to the PRA1 family |
Function
for RABAC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PRAF1_HUMAN, Q9UI14Function: General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicledocking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removalof Rab GTPases from the membrane by GDI (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RABAC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RABAC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for RABAC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RABAC1 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
RABAC1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RABAC1:
|
Pathways & Interactions
for RABAC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RABAC1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/77 Interacting proteins for RABAC1 (Q9UI141, 2, 3 ENSP000002220084) via UniProtKB, MINT, STRING, and/or I2D (see all 77)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| FXR2 | P511161, 2, 3, ENSP000002501134 | EBI-712367,EBI-740459 MINT-66878 I2D:
score=5 STRING: ENSP00000250113 | | PLEKHF2 | Q9H8W41, 2, 3, ENSP000003223734 | EBI-712367,EBI-742388 MINT-67621 I2D:
score=5 STRING: ENSP00000322373 | | RABAC1 | Q9UI141, 2 | EBI-712367,EBI-712367 MINT-8267797 MINT-67868 MINT-65746 | | ADCK3 | Q8NI602, 3, ENSP000003557394 | MINT-66678 I2D:
score=5 STRING: ENSP00000355739 | | DUSP12 | Q9UNI62, 3, ENSP000003569204 | MINT-67416 I2D:
score=5 STRING: ENSP00000356920 |
About this table
|
Drugs & Compounds
for RABAC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RABAC1
Search CenterWatch for drugs/clinical trials and news about RABAC1 / PRAF1
|
Transcripts
for RABAC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RABAC1 gene: NM_006423.2 Unigene Cluster for RABAC1: Rab acceptor 1 (prenylated) Hs.11417 [show with all ESTs]Unigene Representative Sequence: BM4749501 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000222008(uc002osf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RABAC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RABAC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RABAC1 (NM_006423) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RABAC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RABAC1 |
Additional cDNA sequence: AF112202.1 AF112996.1 AJ133534.1 BC008950.2 BT019964.1 CR457214.1 CR542116.1 10 DOTS entries: DT.444231 DT.97838416 DT.92059196 DT.97838349 DT.95214543 DT.100058843 DT.92434407 DT.92434410 DT.100059290 DT.95214563 24/390 AceView cDNA sequences (see all 390): AA303566 BM511738 BM770954 CA310333 CR612417 BF435025 BX089459 BU727397 BM770048 CD368018 CR542116 BU787402 BQ574904 CF242972 BM973549 BQ225284 BQ613843 BQ061589 AI341845 AI916505 CA309402 BQ063454 BQ613743 CA308965
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RABAC1 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for RABAC1
|
Expression
for RABAC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RABAC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGTCCTGC
About this image
See RABAC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RABAC1
SOURCE GeneReport for Unigene cluster: Hs.11417
UniProtKB/Swiss-Prot: PRAF1_HUMAN, Q9UI14Tissue specificity: Ubiquitous. Strongest expression found in placenta, pituitary gland, kidney, lung and stomach
SABiosciences Custom PCR Arrays for RABAC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RABAC1
Browse OriGene validated miRNA SYBR primer pairs
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Orthologs
for RABAC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RABAC1 gene from 5/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Rabac11 , 5 |
Rab acceptor 1 (prenylated)1, 5 |
89.37(n)1
94.59(a)1 |
|
7 (13.73 cM)5
144701 NM_010261.21 NP_034391.11
249697505 |
lizard
(Anolis carolinensis) |
Reptilia |
RABAC16 |
-- |
79(a) |
1 ↔ 1 |
GL344515.1(12937-16782) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.238722 |
Xenopus laevis transcribed sequence with weak similarity more |
73.21(n) |
|
CA981966.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufe26d122 |
Danio rerio Rab acceptor 1 (prenylated) (RABAC1) mRNA, more |
70.91(n) |
|
AY391453.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG14181 |
CG1418 |
49.03(n)
37.42(a) |
|
36035 NM_136695.2 NP_610539.1 |
ENSEMBL Gene Tree for RABAC1 (if available)
TreeFam Gene Tree for RABAC1 (if available) |
Paralogs
for RABAC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for RABAC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RABAC1 (42460833 - 42463528 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RABAC1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RABAC1 |
|
Disorders
/ Diseases
for RABAC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RABAC1 for disorders About GeneDecksing
OMIM gene information: 604925
OMIM disorders: --
3  diseases for RABAC1: About MalaCardscandidiasis endometrial carcinoma carcinoma
Human Genome Epidemiology (HuGE) Navigator: RABAC1 (3 documents)
Export disorders for RABAC1 gene to outside databases
|
Publications
for RABAC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RABAC1 gene, integrated from 9 sources (see all 43):
(articles sorted by number of sources associating them with RABAC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1). (PubMed id 10329441)1, 2, 3 Bucci C.... Bruni C.B. (1999)
- Expression analysis and chromosomal assignment of PRA1 and RILP genes. (PubMed id 11520070)1, 2, 9 Bucci C.... Bruni C.B. (2001)
- Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2). (PubMed id 16481131)1, 2, 9 Fo C.S.... Bachmann A.S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- PRA1 inhibits the extraction of membrane-bound rab GTPase by GDI1. (PubMed id 10751420)1, 3 Hutt D.M....Ngsee J.K. (2000)
- Prenylated Rab acceptor 1 (PRA1) inhibits TCF/beta-catenin signaling by binding to beta-catenin. (PubMed id 16930546)1, 9 Kim J.T....Lim J.S. (2006)
- PRA1 co-localizes with envelope but does not influence primate lentivirus production, infectivity or envelope incorporation. (PubMed id 15914857)1, 9 Blancou P....Desrosiers R.C. (2005)
- Pitfalls in the use of transfected overexpression systems to study membrane proteins function: the case of TSH receptor and PRA1. (PubMed id 14604818)1, 9 Jacobs C. and Pirson I. (2003)
- Yip3 catalyses the dissociation of endosomal Rab-GDI complexes. (PubMed id 14574414)1, 9 Sivars U....Pfeffer S.R. (2003)
- Piccolo, a presynaptic zinc finger protein structurally related to bassoon. (PubMed id 10707984)1, 9 Fenster S.D....Garner C.C. (2000)
|
External Searches for RABAC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RABAC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RABAC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RABAC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RABAC1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RABAC1 gene:
Search GeneIP for patents involving RABAC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RABAC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |
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| |  |  |  |  | | | | |
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 |
 |
 | | | RABAC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibody for RABAC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RABAC1 |
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