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Aliases for RAB9B Gene

Aliases for RAB9B Gene

  • RAB9B, Member RAS Oncogene Family 2 3 5
  • Rab-9-Like Protein 3 4
  • Rab-9L 3 4
  • RAB9L 3 4

External Ids for RAB9B Gene

Previous GeneCards Identifiers for RAB9B Gene

  • GC0XM098381
  • GC0XM099989
  • GC0XM101064
  • GC0XM101849
  • GC0XM102883
  • GC0XM102966
  • GC0XM103077
  • GC0XM092733

Summaries for RAB9B Gene

Entrez Gene Summary for RAB9B Gene

  • This gene encodes a member of a subfamily of RAS small guanosine triphosphate (GTP)-binding proteins that regulate membrane trafficking. The encoded protein may be involved in endosome-to-Golgi transport. [provided by RefSeq, Jan 2010]

GeneCards Summary for RAB9B Gene

RAB9B (RAB9B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Influenza A. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB7B.

UniProtKB/Swiss-Prot for RAB9B Gene

  • Involved in the transport of proteins between the endosomes and the trans Golgi network.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB9B Gene

Genomics for RAB9B Gene

Regulatory Elements for RAB9B Gene

Promoters for RAB9B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAB9B on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB9B Gene

Chromosome:
X
Start:
103,822,322 bp from pter
End:
103,832,282 bp from pter
Size:
9,961 bases
Orientation:
Minus strand

Genomic View for RAB9B Gene

Genes around RAB9B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB9B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB9B Gene

Proteins for RAB9B Gene

  • Protein details for RAB9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP90-RAB9B_HUMAN
    Recommended name:
    Ras-related protein Rab-9B
    Protein Accession:
    Q9NP90
    Secondary Accessions:
    • B2R8M0
    • Q52LX2

    Protein attributes for RAB9B Gene

    Size:
    201 amino acids
    Molecular mass:
    22719 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RAB9B Gene

neXtProt entry for RAB9B Gene

Proteomics data for RAB9B Gene at MOPED

Post-translational modifications for RAB9B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB9B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB9B Gene

Domains & Families for RAB9B Gene

Gene Families for RAB9B Gene

Suggested Antigen Peptide Sequences for RAB9B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NP90

UniProtKB/Swiss-Prot:

RAB9B_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB9B: view

Function for RAB9B Gene

Molecular function for RAB9B Gene

UniProtKB/Swiss-Prot Function:
Involved in the transport of proteins between the endosomes and the trans Golgi network.
genes like me logo Genes that share phenotypes with RAB9B: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB9B Gene

Localization for RAB9B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB9B Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB9B Gene COMPARTMENTS Subcellular localization image for RAB9B gene
Compartment Confidence
cytosol 3
plasma membrane 3
extracellular 2
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RAB9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with RAB9B: view

Pathways & Interactions for RAB9B Gene

genes like me logo Genes that share pathways with RAB9B: view

Pathways by source for RAB9B Gene

Gene Ontology (GO) - Biological Process for RAB9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0042147 retrograde transport, endosome to Golgi IBA --
genes like me logo Genes that share ontologies with RAB9B: view

No data available for SIGNOR curated interactions for RAB9B Gene

Drugs & Compounds for RAB9B Gene

No Compound Related Data Available

Transcripts for RAB9B Gene

mRNA/cDNA for RAB9B Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(76) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB9B Gene

RAB9B, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB9B Gene

No ASD Table

Relevant External Links for RAB9B Gene

GeneLoc Exon Structure for
RAB9B
ECgene alternative splicing isoforms for
RAB9B

Expression for RAB9B Gene

mRNA expression in normal human tissues for RAB9B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAB9B Gene

This gene is overexpressed in Brain (24.6), Frontal cortex (8.1), Fetal testis (7.9), and Fetal heart (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB9B Gene



SOURCE GeneReport for Unigene cluster for RAB9B Gene Hs.522736

mRNA Expression by UniProt/SwissProt for RAB9B Gene

Q9NP90-RAB9B_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with RAB9B: view

Protein tissue co-expression partners for RAB9B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RAB9B Gene

Orthologs for RAB9B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB9B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAB9B 35
  • 94.03 (n)
  • 99.5 (a)
RAB9B 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB9B 35
  • 94.03 (n)
  • 99.5 (a)
RAB9B 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab9b 35
  • 92.04 (n)
  • 98.01 (a)
Rab9b 16
Rab9b 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAB9B 35
  • 99.83 (n)
  • 100 (a)
RAB9B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab9b 35
  • 91.54 (n)
  • 98.51 (a)
oppossum
(Monodelphis domestica)
Mammalia RAB9B 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB9B 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB9B 35
  • 80.76 (n)
  • 93.53 (a)
RAB9B 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB9B 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab9b 35
  • 74.46 (n)
  • 85.07 (a)
zebrafish
(Danio rerio)
Actinopterygii rab9b 35
  • 68.82 (n)
  • 77.61 (a)
rab9b 36
  • 77 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1580 35
fruit fly
(Drosophila melanogaster)
Insecta CG9994 37
  • 54 (a)
Rab7 37
  • 57 (a)
Rab9 35
  • 56.63 (n)
  • 56.45 (a)
Rab9 36
  • 42 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009846 35
  • 53.87 (n)
  • 56.06 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT7 36
  • 46 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToMany
Species with no ortholog for RAB9B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB9B Gene

ENSEMBL:
Gene Tree for RAB9B (if available)
TreeFam:
Gene Tree for RAB9B (if available)

Paralogs for RAB9B Gene

Paralogs for RAB9B Gene

Pseudogenes.org Pseudogenes for RAB9B Gene

genes like me logo Genes that share paralogs with RAB9B: view

Variants for RAB9B Gene

Sequence variations from dbSNP and Humsavar for RAB9B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs500662 -- 103,830,478(+) AAAAC(C/G)CTTAT intron-variant
rs517312 -- 103,829,872(-) TCCAT(A/G)GAGGA intron-variant
rs526974 -- 103,831,017(+) GCTAG(G/T)CACTG intron-variant
rs529980 -- 103,823,293(+) GAGCT(A/G)TGGGG utr-variant-3-prime
rs531615 -- 103,831,520(+) ACTAG(A/T)TAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB9B Gene

Variant ID Type Subtype PubMed ID
dgv2459e1 CNV Complex 17122850

Variation tolerance for RAB9B Gene

Residual Variation Intolerance Score: 30% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB9B Gene

HapMap Linkage Disequilibrium report
RAB9B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB9B Gene

Disorders for RAB9B Gene

Relevant External Links for RAB9B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB9B

No disorders were found for RAB9B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB9B Gene

Publications for RAB9B Gene

  1. cDNA cloning of a new member of the Ras superfamily, RAB9-like, on the human chromosome Xq22.1-q22.3 region. (PMID: 11043518) Seki N. … Saito T. (J. Hum. Genet. 2000) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PMID: 21255211) Seto S. … Koide Y. (Traffic 2011) 3
  4. Live cell visualization of the interactions between HIV-1 Gag and the cellular RNA-binding protein Staufen1. (PMID: 20459747) Milev M.P. … Mouland A.J. (Retrovirology 2010) 3
  5. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S. … Barr F.A. (J. Cell Biol. 2010) 3

Products for RAB9B Gene

Sources for RAB9B Gene

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