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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB9B Gene

protein-coding   GIFtS: 54
GCID: GC0XM103077

RAB9B, Member RAS Oncogene Family

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAB9B, Member RAS Oncogene Family1 2
RAB9L2 3 5
Rab-9-Like Protein2 3
Rab-9L2 3
RAB9-Like Protein2
Ras-Related Protein Rab-9B2

External Ids:    HGNC: 140901   Entrez Gene: 512092   Ensembl: ENSG000001235707   OMIM: 3002855   UniProtKB: Q9NP903   

Export aliases for RAB9B gene to outside databases

Previous GC identifers: GC0XM098381 GC0XM099989 GC0XM101064 GC0XM101849 GC0XM102883 GC0XM102966 GC0XM092733


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAB9B Gene:
This gene encodes a member of a subfamily of RAS small guanosine triphosphate (GTP)-binding proteins that regulate
membrane trafficking. The encoded protein may be involved in endosome-to-Golgi transport. (provided by RefSeq,
Jan 2010)

GeneCards Summary for RAB9B Gene: 
RAB9B (RAB9B, member RAS oncogene family) is a protein-coding gene. Diseases associated with RAB9B include pelizaeus-merzbacher disease, and measles, and among its related super-pathways are Sertoli-Sertoli Cell Junction Dynamics and Influenza A. GO annotations related to this gene include GDP binding and GTP binding. An important paralog of this gene is RABL2B.

UniProtKB/Swiss-Prot: RAB9B_HUMAN, Q9NP90
Function: Involved in the transport of proteins between the endosomes and the trans Golgi network (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB9B gene promoter:
         MEF-2   Meis-1b   Evi-1   PPAR-alpha   MEF-2A   CREB   deltaCREB   Meis-1a   aMEF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB9B promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB9B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB9B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.1-q22.3   Ensembl cytogenetic band:  Xq22.2   HGNC cytogenetic band: Xq22.1-q22.3

RAB9B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB9B gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM103077:  view genomic region     (about GC identifiers)

Start:
103,077,252 bp from pter      End:
103,087,212 bp from pter
Size:
9,961 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RAB9B_HUMAN, Q9NP90 (See protein sequence)
Recommended Name: Ras-related protein Rab-9B  
Size: 201 amino acids; 22719 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cytoplasmic vesicle, phagosome.
Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Recruited to
phagosomes containing S.aureus or M.tuberculosis
1 PDB 3D structure from and Proteopedia for RAB9B:
2OCB (3D)    
Secondary accessions: B2R8M0 Q52LX2

Explore the universe of human proteins at neXtProt for RAB9B: NX_Q9NP90

Explore proteomics data for RAB9B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NP90

  • RAB9B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAB9B Protein Expression
    REFSEQ proteins: NP_057454.1  
    ENSEMBL proteins: 
     ENSP00000243298  

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    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane IEA--

    RAB9B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9NP90

    ProtoNet protein and cluster: Q9NP90

    1 Blocks protein domain: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RAB9B_HUMAN, Q9NP90
    Similarity: Belongs to the small GTPase superfamily. Rab family


    RAB9B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAB9B_HUMAN, Q9NP90
    Function: Involved in the transport of proteins between the endosomes and the trans Golgi network (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005515protein binding IPI19490898
    GO:0005525GTP binding NAS--
    GO:0019003GDP binding IDA--
         
    RAB9B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RAB9B:
     Synthetic lethal with Ras 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target RAB9B:
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    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB9B (see all 44):
    hsa-miR-4272 hsa-miR-15a hsa-miR-503 hsa-miR-301a hsa-miR-488 hsa-miR-759 hsa-miR-124 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidRAB9B 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAB9B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    2Influenza A
    Measles0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB9B
        Epithelial Tight Junctions


    1         Kegg Pathway  (Kegg details for RAB9B):
        Measles


    RAB9B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAB9B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for RAB9B (Q9NP903 ENSP000002432984) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOBTB3O949553, ENSP000003693184I2D: score=1 STRING: ENSP00000369318
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006895Golgi to endosome transport NAS--
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----

    RAB9B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAB9B

    Search CenterWatch for drugs/clinical trials and news about RAB9B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAB9B gene: 
    NM_016370.2  

    Unigene Cluster for RAB9B:

    RAB9B, member RAS oncogene family
    Hs.522736  [show with all ESTs]
    Unigene Representative Sequence: NM_016370
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000243298(uc004eli.2 uc004ell.2)
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidRAB9B 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB036693.1 AK313425.1 BC041336.1 BC070069.1 BC093756.1 BC093758.1 

    1 DOTS entry:

    DT.209540 

    24/76 AceView cDNA sequences (see all 76):

    AI253306 AI334284 BM661661 AA699329 BM504868 AI192685 BC018033 BM353846 
    BX477720 AV725682 AW172843 BX445447 AW130622 BC041336 NM_016370 W19794 
    AI743862 AL599900 AA992664 BM353575 AI204553 AA652438 BF432968 BX100920 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB9B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGGTCACA
    RAB9B Expression
    About this image


    See RAB9B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAB9B

    SOURCE GeneReport for Unigene cluster: Hs.522736

    UniProtKB/Swiss-Prot: RAB9B_HUMAN, Q9NP90
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RAB9B gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab9b1 , 5 RAB9B, member RAS oncogene family1, 5 92.04(n)1
    98.01(a)1
      X (59.10 cM)5
    3196421  NM_176971.21  NP_795945.11 
     1368581475 
    chicken
    (Gallus gallus)
    Aves RAB9B1 RAB9B, member RAS oncogene family 80.76(n)
    93.53(a)
      422187  XM_001232251.2  XP_001232252.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAB9B6
    Uncharacterized protein
    86(a)
    1 ↔ 1
    GL343686.1(89560-90165)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000033631 ras-related protein Rab-9B-like 68.99(n)
    77.61(a)
      100003363  XM_001339226.3  XP_001339262.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rab73
    Rab91
    endosome to lysosome transport RAB
    small monomeric more3
    CG9994-PA1
    57(a)
    (best of 2)3
    56.63(n)1
    56.45(a)1
      95D53
    352211  NM_136122.31  NP_609966.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YPT76
    Rab family GTPase; GTP-binding protein of the rab ...
    45(a)
    1 → many
    XIII(267174-267800)


    ENSEMBL Gene Tree for RAB9B (if available)
    TreeFam Gene Tree for RAB9B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAB9B gene
    RABL2B2  RAB9A2  RAB7A2  RAB322  RAB7L12  RAB382  RABL2A2  
    18/87 SIMAP similar genes for RAB9B using alignment to 1 protein entry:     RAB9B_HUMAN(see all similar genes):
    RAB9A    RANP1    RAB8B    RAB11A    RAB15    RAB7A
    RAB11B    RAB8A    DKFZp686J07132    RAB14    RAB43    RAB4A
    RAB12    RAB13    RAB23    RAB39B    RAB19    RAB30

    RAB9B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RAB9B
    PGOHUM00000235722


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/149 SNPs in RAB9B are shown (see all 149)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1920481471,2
    --103046241(+) AATAAA/GGAAAT 1 -- ds50010--------
    rs1817439691,2
    --103046319(+) ATGAGC/TTTGAG 1 -- ds50010--------
    rs5519811,2
    C,F,A--103046345(+) gattgC/Tgccac 1 -- ds50013Minor allele frequency- T:0.02NA EA 252
    rs59458301,2
    C,F,A,H--103046527(+) CATGAT/CCCAGA 1 -- ds500117Minor allele frequency- C:0.32NS EA NA WA 1949
    rs1856712171,2
    --103046541(+) CACATC/TCAGTG 1 -- ds50010--------
    rs1128005631,2
    C--103046572(+) ATTAAA/TAAGTA 1 -- ds50011Minor allele frequency- T:0.00CSA 1
    rs1901817131,2
    --103046687(+) GATGAC/TTTTTT 1 -- ut310--------
    rs169840601,2
    C,F,H--103046765(+) TGTGGA/GATACC 1 -- ut31 ese315Minor allele frequency- G:0.06NA NS EA 1862
    rs1424605411,2
    C--103046812(+) TTAACC/TTGATA 1 -- ut310--------
    rs1824068431,2
    --103046866(+) AGTTAG/TCCAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RAB9B (103077252 - 103087212 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RAB9B:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv2459e1CNV Complex17122850


    Locus Specific Mutation Databases (LSDB): RAB9B
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300285    OMIM disorders: --

    3 diseases for RAB9B:    About MalaCards
    pelizaeus-merzbacher disease    measles    tuberculosis

    1 disease from the University of Copenhagen DISEASES database for RAB9B:
    Pelizaeus-Merzbacher disease

    RAB9B for disorders           About GeneDecksing


    Export disorders for RAB9B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB9B gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with RAB9B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of a new member of the Ras superfamily, RAB9-like, on the human chromosome Xq22.1-q22.3 region. (PubMed id 11043518)1, 2, 3 Seki N.... Saito T. (2000)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    5. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PubMed id 21255211)2 Seto S.... Koide Y. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Live cell visualization of the interactions between H IV-1 Gag and the cellular RNA-binding protein Staufen1. (PubMed id 20459747)1 Milev M.P....Mouland A.J. (2010)
    8. Human immunodeficiency virus type-1 gag and host vesic ular trafficking pathways. (PubMed id 20012524)1 Chu H....Spearman P. (2009)
    9. RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport. (PubMed id 19490898)1 Espinosa E.J.... Pfeffer S.R. (2009)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51209 HGNC: 14090 AceView: RAB9B Ensembl:ENSG00000123570 euGenes: HUgn51209
    ECgene: RAB9B Kegg: 51209 H-InvDB: RAB9B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB9B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB9B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAB9B gene:
    Search GeneIP for patents involving RAB9B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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