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Aliases for RAB9B Gene

Aliases for RAB9B Gene

  • RAB9B, Member RAS Oncogene Family 2 3 5
  • Rab-9-Like Protein 3 4
  • Rab-9L 3 4
  • RAB9L 3 4
  • Ras-Related Protein Rab-9B 3

External Ids for RAB9B Gene

Previous GeneCards Identifiers for RAB9B Gene

  • GC0XM098381
  • GC0XM099989
  • GC0XM101064
  • GC0XM101849
  • GC0XM102883
  • GC0XM102966
  • GC0XM103077
  • GC0XM092733

Summaries for RAB9B Gene

Entrez Gene Summary for RAB9B Gene

  • This gene encodes a member of a subfamily of RAS small guanosine triphosphate (GTP)-binding proteins that regulate membrane trafficking. The encoded protein may be involved in endosome-to-Golgi transport. [provided by RefSeq, Jan 2010]

GeneCards Summary for RAB9B Gene

RAB9B (RAB9B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Golgi-to-ER retrograde transport. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB9A.

UniProtKB/Swiss-Prot for RAB9B Gene

  • Involved in the transport of proteins between the endosomes and the trans Golgi network.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB9B Gene

Genomics for RAB9B Gene

Regulatory Elements for RAB9B Gene

Enhancers for RAB9B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RAB9B on UCSC Golden Path with GeneCards custom track

Promoters for RAB9B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAB9B on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB9B Gene

Chromosome:
X
Start:
103,822,322 bp from pter
End:
103,832,282 bp from pter
Size:
9,961 bases
Orientation:
Minus strand

Genomic View for RAB9B Gene

Genes around RAB9B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB9B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB9B Gene

Proteins for RAB9B Gene

  • Protein details for RAB9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP90-RAB9B_HUMAN
    Recommended name:
    Ras-related protein Rab-9B
    Protein Accession:
    Q9NP90
    Secondary Accessions:
    • B2R8M0
    • Q52LX2

    Protein attributes for RAB9B Gene

    Size:
    201 amino acids
    Molecular mass:
    22719 Da
    Quaternary structure:
    • Interacts (GTP-bound form) with SGSM1; the GDP-bound form has much lower affinity for SGSM1.

    Three dimensional structures from OCA and Proteopedia for RAB9B Gene

neXtProt entry for RAB9B Gene

Post-translational modifications for RAB9B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB9B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB9B Gene

Domains & Families for RAB9B Gene

Gene Families for RAB9B Gene

Protein Domains for RAB9B Gene

Suggested Antigen Peptide Sequences for RAB9B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NP90

UniProtKB/Swiss-Prot:

RAB9B_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB9B: view

Function for RAB9B Gene

Molecular function for RAB9B Gene

UniProtKB/Swiss-Prot Function:
Involved in the transport of proteins between the endosomes and the trans Golgi network.

Gene Ontology (GO) - Molecular Function for RAB9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19490898
GO:0005525 GTP binding IEA --
GO:0019003 GDP binding IDA 20937701
genes like me logo Genes that share ontologies with RAB9B: view
genes like me logo Genes that share phenotypes with RAB9B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAB9B

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB9B Gene

Localization for RAB9B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB9B Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB9B Gene COMPARTMENTS Subcellular localization image for RAB9B gene
Compartment Confidence
cytosol 3
plasma membrane 3
extracellular 2
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RAB9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IEA --
GO:0030670 phagocytic vesicle membrane IEA --
GO:0045335 phagocytic vesicle IDA 21255211
genes like me logo Genes that share ontologies with RAB9B: view

Pathways & Interactions for RAB9B Gene

genes like me logo Genes that share pathways with RAB9B: view

Pathways by source for RAB9B Gene

Gene Ontology (GO) - Biological Process for RAB9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
GO:0042147 retrograde transport, endosome to Golgi IBA --
genes like me logo Genes that share ontologies with RAB9B: view

No data available for SIGNOR curated interactions for RAB9B Gene

Drugs & Compounds for RAB9B Gene

No Compound Related Data Available

Transcripts for RAB9B Gene

mRNA/cDNA for RAB9B Gene

Unigene Clusters for RAB9B Gene

RAB9B, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAB9B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB9B Gene

No ASD Table

Relevant External Links for RAB9B Gene

GeneLoc Exon Structure for
RAB9B
ECgene alternative splicing isoforms for
RAB9B

Expression for RAB9B Gene

mRNA expression in normal human tissues for RAB9B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAB9B Gene

This gene is overexpressed in Brain (24.6), Frontal cortex (8.1), Fetal testis (7.9), and Fetal heart (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB9B Gene



Protein tissue co-expression partners for RAB9B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAB9B Gene:

RAB9B

SOURCE GeneReport for Unigene cluster for RAB9B Gene:

Hs.522736

mRNA Expression by UniProt/SwissProt for RAB9B Gene:

Q9NP90-RAB9B_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with RAB9B: view

Primer Products

No data available for mRNA differential expression in normal tissues for RAB9B Gene

Orthologs for RAB9B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB9B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAB9B 34
  • 94.03 (n)
  • 99.5 (a)
RAB9B 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB9B 34
  • 94.03 (n)
  • 99.5 (a)
RAB9B 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab9b 34
  • 92.04 (n)
  • 98.01 (a)
Rab9b 16
Rab9b 35
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAB9B 34
  • 99.83 (n)
  • 100 (a)
RAB9B 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab9b 34
  • 91.54 (n)
  • 98.51 (a)
oppossum
(Monodelphis domestica)
Mammalia RAB9B 35
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB9B 35
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB9B 34
  • 80.76 (n)
  • 93.53 (a)
RAB9B 35
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB9B 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab9b 34
  • 74.46 (n)
  • 85.07 (a)
zebrafish
(Danio rerio)
Actinopterygii rab9b 34
  • 68.82 (n)
  • 77.61 (a)
rab9b 35
  • 77 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1580 34
fruit fly
(Drosophila melanogaster)
Insecta CG9994 36
  • 54 (a)
Rab7 36
  • 57 (a)
Rab9 34
  • 56.63 (n)
  • 56.45 (a)
Rab9 35
  • 42 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009846 34
  • 53.87 (n)
  • 56.06 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT7 35
  • 46 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 58 (a)
OneToMany
Species where no ortholog for RAB9B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB9B Gene

ENSEMBL:
Gene Tree for RAB9B (if available)
TreeFam:
Gene Tree for RAB9B (if available)

Paralogs for RAB9B Gene

Paralogs for RAB9B Gene

Pseudogenes.org Pseudogenes for RAB9B Gene

genes like me logo Genes that share paralogs with RAB9B: view

Variants for RAB9B Gene

Sequence variations from dbSNP and Humsavar for RAB9B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747849601 -- 103,825,528(+) TGAAG(A/G)TCAAG reference, missense
rs747979283 -- 103,829,672(+) GGCAA(-/G)GTCTT intron-variant
rs748074837 -- 103,824,777(+) GCTTG(C/G)CAAGA utr-variant-3-prime
rs748406972 -- 103,825,379(+) CTCCT(C/G)AGTAG reference, missense
rs748439997 -- 103,822,233(+) CAGTG(C/T)AGCCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RAB9B Gene

Variant ID Type Subtype PubMed ID
esv2758880 CNV gain 17122850

Variation tolerance for RAB9B Gene

Residual Variation Intolerance Score: 30% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB9B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB9B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB9B Gene

Disorders for RAB9B Gene

Relevant External Links for RAB9B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB9B

No disorders were found for RAB9B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB9B Gene

Publications for RAB9B Gene

  1. cDNA cloning of a new member of the Ras superfamily, RAB9-like, on the human chromosome Xq22.1-q22.3 region. (PMID: 11043518) Seki N. … Saito T. (J. Hum. Genet. 2000) 2 3 4 65
  2. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PMID: 21255211) Seto S. … Koide Y. (Traffic 2011) 3 4 65
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65

Products for RAB9B Gene

Sources for RAB9B Gene

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