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Aliases for RAB9A Gene

Aliases for RAB9A Gene

  • RAB9A, Member RAS Oncogene Family 2 3 5
  • RAB9, Member RAS Oncogene Family 2 3
  • RAB9 3 4

External Ids for RAB9A Gene

Previous HGNC Symbols for RAB9A Gene

  • RAB9

Previous GeneCards Identifiers for RAB9A Gene

  • GC0XP012946
  • GC0XP012527
  • GC0XP013068
  • GC0XP013466
  • GC0XP013617
  • GC0XP011465

Summaries for RAB9A Gene

GeneCards Summary for RAB9A Gene

RAB9A (RAB9A, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF) and Normal wtCFTR traffic / ER-to-Golgi. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB7B.

UniProtKB/Swiss-Prot for RAB9A Gene

  • Involved in the transport of proteins between the endosomes and the trans Golgi network.

Gene Wiki entry for RAB9A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB9A Gene

Genomics for RAB9A Gene

Regulatory Elements for RAB9A Gene

Enhancers for RAB9A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RAB9A on UCSC Golden Path with GeneCards custom track

Promoters for RAB9A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAB9A on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB9A Gene

13,689,121 bp from pter
13,710,506 bp from pter
21,386 bases
Plus strand

Genomic View for RAB9A Gene

Genes around RAB9A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB9A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB9A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB9A Gene

Proteins for RAB9A Gene

  • Protein details for RAB9A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-9A
    Protein Accession:
    Secondary Accessions:
    • A8K390
    • Q6ICN1

    Protein attributes for RAB9A Gene

    201 amino acids
    Molecular mass:
    22838 Da
    Quaternary structure:
    • Interacts (preferentially in its GTP-bound form) with GCC2 (via its GRIP domain).

    Three dimensional structures from OCA and Proteopedia for RAB9A Gene

neXtProt entry for RAB9A Gene

Proteomics data for RAB9A Gene at MOPED

Post-translational modifications for RAB9A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB9A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB9A Gene

Domains & Families for RAB9A Gene

Gene Families for RAB9A Gene

Suggested Antigen Peptide Sequences for RAB9A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB9A: view

Function for RAB9A Gene

Molecular function for RAB9A Gene

UniProtKB/Swiss-Prot Function:
Involved in the transport of proteins between the endosomes and the trans Golgi network.
genes like me logo Genes that share phenotypes with RAB9A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB9A Gene

Localization for RAB9A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB9A Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Endoplasmic reticulum membrane. Golgi apparatus membrane. Late endosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome. Note=Colocalizes with OSBPL1A at the late endosome (PubMed:16176980). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000269 PubMed:16176980, ECO:0000269 PubMed:21255211}.

Subcellular locations from

Jensen Localization Image for RAB9A Gene COMPARTMENTS Subcellular localization image for RAB9A gene
Compartment Confidence
endosome 5
extracellular 5
lysosome 5
vacuole 5
cytosol 4
endoplasmic reticulum 4
golgi apparatus 4
plasma membrane 3
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RAB9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 15078902
GO:0005770 late endosome IDA 15078902
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RAB9A: view

Pathways & Interactions for RAB9A Gene

genes like me logo Genes that share pathways with RAB9A: view

Gene Ontology (GO) - Biological Process for RAB9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006913 nucleocytoplasmic transport IEA --
GO:0042147 retrograde transport, endosome to Golgi IBA --
GO:0045921 positive regulation of exocytosis IMP 19966785
genes like me logo Genes that share ontologies with RAB9A: view

No data available for SIGNOR curated interactions for RAB9A Gene

Drugs & Compounds for RAB9A Gene

(3) Drugs for RAB9A Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Benzoic Acid Experimental Pharma Target 7
Guanosine diphosphate Experimental Pharma Target 0

(3) Additional Compounds for RAB9A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RAB9A: view

Transcripts for RAB9A Gene

Unigene Clusters for RAB9A Gene

RAB9A, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB9A Gene

No ASD Table

Relevant External Links for RAB9A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB9A Gene

mRNA expression in normal human tissues for RAB9A Gene

Protein differential expression in normal tissues from HIPED for RAB9A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.4) and Bone (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB9A Gene

SOURCE GeneReport for Unigene cluster for RAB9A Gene Hs.495704

genes like me logo Genes that share expression patterns with RAB9A: view

Protein tissue co-expression partners for RAB9A Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAB9A Gene

Orthologs for RAB9A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB9A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RAB9A 35
  • 91.04 (n)
  • 97.51 (a)
RAB9A 36
  • 97 (a)
(Canis familiaris)
Mammalia RAB9A 35
  • 93.7 (n)
  • 99.5 (a)
RAB9A 36
  • 100 (a)
(Mus musculus)
Mammalia Rab9 35
  • 90.38 (n)
  • 95.52 (a)
Rab9 16
Rab9 36
  • 96 (a)
(Pan troglodytes)
Mammalia RAB9A 35
  • 100 (n)
  • 100 (a)
RAB9A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rab9a 35
  • 91.38 (n)
  • 95.52 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 80 (a)
-- 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia RAB9A 36
  • 98 (a)
(Gallus gallus)
Aves RAB9A 35
  • 83.75 (n)
  • 94.03 (a)
RAB9A 36
  • 94 (a)
(Anolis carolinensis)
Reptilia RAB9A 36
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab9a 35
  • 78.44 (n)
  • 90.05 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17219 35
(Danio rerio)
Actinopterygii rab9a 35
  • 72.8 (n)
  • 85.07 (a)
rab9a 36
  • 85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9994 37
  • 55 (a)
Rab7 37
  • 55 (a)
Rab9 36
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT7 36
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
Species with no ortholog for RAB9A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB9A Gene

Gene Tree for RAB9A (if available)
Gene Tree for RAB9A (if available)

Paralogs for RAB9A Gene

Paralogs for RAB9A Gene

genes like me logo Genes that share paralogs with RAB9A: view

Variants for RAB9A Gene

Sequence variations from dbSNP and Humsavar for RAB9A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747733912 -- 13,698,251(+) CCACC(A/G)CTGTT intron-variant
rs747805802 -- 13,695,480(+) CAGGT(A/G)CCTAG intron-variant
rs748045675 -- 13,703,444(+) CAACC(A/C)CAAAT intron-variant
rs748105664 -- 13,699,606(+) AGGTT(C/G)CTGGG intron-variant
rs748107118 -- 13,706,508(+) TGCCT(C/T)AGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB9A Gene

Variant ID Type Subtype PubMed ID
nsv528634 CNV Gain 19592680

Variation tolerance for RAB9A Gene

Residual Variation Intolerance Score: 30.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.66% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RAB9A Gene

Disorders for RAB9A Gene

Relevant External Links for RAB9A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RAB9A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB9A Gene

Publications for RAB9A Gene

  1. Cloning and mapping of human Rab7 and Rab9 cDNA sequences and identification of a Rab9 pseudogene. (PMID: 9126495) Davies J.P. … Ioannou Y.A. (Genomics 1997) 2 3 4 23 67
  2. Endosomal lipid accumulation in NPC1 leads to inhibition of PKC, hypophosphorylation of vimentin and Rab9 entrapment. (PMID: 18681838) Walter M. … Ioannou Y.A. (Biol. Cell 2009) 3 23
  3. The Salmonella virulence protein SifA is a G protein antagonist. (PMID: 18787122) Jackson L.K. … Haldar K. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 23
  4. TIP47 is a key effector for Rab9 localization. (PMID: 16769818) Aivazian D. … Pfeffer S. (J. Cell Biol. 2006) 3 23
  5. Rab9 GTPase is required for replication of human immunodeficiency virus type 1, filoviruses, and measles virus. (PMID: 16140752) Murray J.L. … Hodge T.W. (J. Virol. 2005) 3 23

Products for RAB9A Gene

Sources for RAB9A Gene