RAB8B Gene
protein-coding GIFtS: 51
GCID: GC15P063481
|
|
RAB8B, member RAS oncogene family
| |
Aliases
for RAB8B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RAB8B, Member RAS Oncogene Family1 2 | | RAB-8b Protein2 | | Ras-Related Protein Rab-8B2 |
Export aliases for RAB8B gene to outside databasesPrevious GC identifers: GC15P061197 GC15P061268 GC15P040304 |
Summaries
for RAB8B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RAB8B:
RAB proteins, like RAB8B, are low molecular mass monomeric GTPases that localize on the cytoplasmic surfaces ofdistinct membrane-bound organelles. RAB proteins function in intracellular vesicle transport by aiding in the dockingand/or fusion of vesicles with their target membranes (summary by Chen et al., 1997 (PubMed 9030196)).(supplied byOMIM, Nov 2010)
UniProtKB/Swiss-Prot: RAB8B_HUMAN, Q92930Function: May be involved in vesicular trafficking and neurotransmitter release (By similarity). May participate incell junction dynamics in Sertoli cells (By similarity)
Gene Wiki entry for RAB8B
|
Genomic Views
for RAB8B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAB8B gene promoter:
GR TBP SRF SRF (504 AA) AP-2gamma NF-kappaB AREB6 TFIID GR-alpha NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAB8B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB8B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q22.2 Ensembl cytogenetic band: 15q22.2 HGNC cytogenetic band: 15q22RAB8B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P063481: view genomic region
(about GC identifiers)
Start:
|
63,481,668 bp from pter |
End:
|
63,559,981 bp from pter |
Size:
|
78,314 bases |
Orientation:
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plus strand |
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Proteins
for RAB8B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RAB8B_HUMAN, Q92930 (See
protein sequence)Recommended Name: Ras-related protein Rab-8B precursor Size: 207 amino acids; 23584 Da
Subunit: Interacts with OTOF and PEX5R (By similarity). Interacts with RAB3IP. Interacts with VIM AND CDH1 (Bysimilarity). Associated with actin, delta-catenin and alpha and beta tubulins (By similarity)
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cytoplasmic vesicle, phagosome.Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containingS.aureus or M.tuberculosis
Secondary accessions: Q5JPC4 Q9P293Explore the universe of human proteins at neXtProt for RAB8B: NX_Q92930
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92930
RAB8B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057614.1
ENSEMBL proteins: ENSP00000312734 ENSP00000453236 ENSP00000453679 ENSP00000453111 ENSP00000453982 ENSP00000405463
Human Recombinant Protein Products for RAB8B:
Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table
RAB8B for ontologies About GeneDecksing
RAB8B Antibody Products:
Assay Products for RAB8B: |
Protein
Domains /
Families
for RAB8B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAB8B for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q92930ProtoNet protein and cluster: Q92930 1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: RAB8B_HUMAN, Q92930Similarity: Belongs to the small GTPase superfamily. Rab family |
Function
for RAB8B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: RAB8B_HUMAN, Q92930Function: May be involved in vesicular trafficking and neurotransmitter release (By similarity). May participate incell junction dynamics in Sertoli cells (By similarity) Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
RAB8B for ontologies About GeneDecksing
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB8B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RAB8B (NM_016530) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAB8B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB8B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB8B |
|
Pathways & Interactions
for RAB8B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Sertoli-Sertoli Cell Junction Dynamics | |
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RAB8B
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAB8B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 21)
5/60 Interacting proteins for RAB8B (Q929303 ENSP000003127344) via UniProtKB, MINT, STRING, and/or I2D (see all 60)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006184 | GTP catabolic process |
NAS | 9030196 | | GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0015031 | protein transport |
NAS | -- | | GO:0031346 | positive regulation of cell projection organization |
IEA | -- | | GO:0034332 | adherens junction organization |
ISS | -- |
RAB8B for ontologies About GeneDecksing
|
Drugs & Compounds
for RAB8B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RAB8B
2 DrugBank Compounds for RAB8B About this table
Search CenterWatch for drugs/clinical trials and news about RAB8B
|
Transcripts
for RAB8B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RAB8B gene: NM_016530.2 Unigene Cluster for RAB8B: RAB8B, member RAS oncogene family Hs.389733 [show with all ESTs]Unigene Representative Sequence: NM_0165306 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000321437(uc002alz.3 uc010uih.2) ENST00000558990 ENST00000558119
ENST00000559927 ENST00000559006 ENST00000448330
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB8B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB8B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RAB8B (NM_016530) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAB8B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB8B |
Additional cDNA sequence: AB038995.1 AK001111.1 AK095444.1 AK297598.1 AL133607.1 AL713722.1 AL833365.1 BC020654.1 U66624.1 8 DOTS entries: DT.107660 DT.100796552 DT.95290899 DT.100796557 DT.100705723 DT.100796553 DT.100796554 DT.95139038 24/209 AceView cDNA sequences (see all 209): BX494980 AI261827 BX956689 BU192097 CF138553 CB215298 CD364456 AL833365 CB960099 AI831982 BC020654 BG536384 AA377347 AW629477 BU520819 AA703019 BQ719944 BU632165 N34690 AA362265 AI206228 AW503673 AI610982 CA454266
GeneLoc Exon Structure
|
Expression
for RAB8B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RAB8B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGTTAATCT
About this image
See RAB8B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAB8B
SOURCE GeneReport for Unigene cluster: Hs.389733
SABiosciences Custom PCR Arrays for RAB8B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB8B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAB8B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB8B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB8B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB8B |
Orthologs
for RAB8B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RAB8B gene from 6/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RAB8B1 |
RAB8B, member RAS oncogene family |
87.39(n)
97.3(a) |
|
415371 XM_413757.3 XP_413757.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
rab8b1 |
RAB8B, member RAS oncogene family |
80.19(n)
94.2(a) |
|
100093706 NM_001099259.1 NP_001092729.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Rab86 |
Rab-protein 8 |
79(a) |
1 → many |
3L(19860588-19864178) |
worm
(Caenorhabditis elegans) |
Secernentea |
rab-86 |
RAB family member (rab-8) |
73(a) |
1 → many |
I(3682896-3684121) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
RABE1e1 |
RAB GTPase-like protein E1E |
64.24(n)
64.06(a) |
|
820148 NM_111825.3 NP_187601.1 |
rice
(Oryza sativa) |
Liliopsida |
AK104346.12 |
-- |
72.37(n) |
|
AK104346.1 |
ENSEMBL Gene Tree for RAB8B (if available)
TreeFam Gene Tree for RAB8B (if available) |
Paralogs
for RAB8B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RAB8B gene
- RAB102 RAB192 RAB432 RAB182 RAB262 RAB8A2 RAB372 RAB352
- RAB1B2 RAB122 RAB302 RAB1A2 RAB132
18/116 SIMAP similar genes for RAB8B using alignment to 6 protein entries: RAB8B_HUMAN (see all proteins)
(see all similar genes):RAB8A RAB10 rab1b RAB13 RAB3C DKFZp686J06205
RAB3A RAB1C RAB3D RAB15 RAB1A RAB3B
DKFZp686J07132 RAB35 RAB43 RAB1B RAB30 RAB19
RAB8B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for RAB8B
PGOHUM00000262037
|
Genomic Variants
for RAB8B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RAB8B (63481668 - 63559981 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RAB8B
2 CNVs: 66819 72264 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB8B |
|
Disorders
/ Diseases
for RAB8B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RAB8B for disorders About GeneDecksing
OMIM gene information: 613532
OMIM disorders: --
1  disease for RAB8B: About MalaCardsmelanoma
Human Genome Epidemiology (HuGE) Navigator: RAB8B (1 document)
Export disorders for RAB8B gene to outside databases
|
Publications
for RAB8B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RAB8B gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with RAB8B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- RAB GTPases expressed in human melanoma cells. (PubMed id 9030196)1, 2, 3 Chen D.... Gahl W.A. (1997)
- Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form. (PubMed id 18772196)1, 3 Heidrych P....Blin N. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport. (PubMed id 12221131)1, 2 Hattula K....Peranen J. (2002)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PubMed id 21255211)2 Seto S.... Koide Y. (2011)
- Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
|
External Searches for RAB8B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RAB8B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RAB8B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB8B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RAB8B gene:
Search GeneIP for patents involving RAB8B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RAB8B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAB8B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB8B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB8B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB8B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB8B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB8B |
| |
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| |  |  |  |  | | | | |
 |
 |
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 | | | RAB8B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB8B |
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