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Aliases for RAB8B Gene

Aliases for RAB8B Gene

  • RAB8B, Member RAS Oncogene Family 2 3

External Ids for RAB8B Gene

Previous GeneCards Identifiers for RAB8B Gene

  • GC15P061197
  • GC15P061268
  • GC15P063481
  • GC15P040304

Summaries for RAB8B Gene

Entrez Gene Summary for RAB8B Gene

  • RAB proteins, like RAB8B, are low molecular mass monomeric GTPases that localize on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB proteins function in intracellular vesicle transport by aiding in the docking and/or fusion of vesicles with their target membranes (summary by Chen et al., 1997 [PubMed 9030196]).[supplied by OMIM, Nov 2010]

GeneCards Summary for RAB8B Gene

RAB8B (RAB8B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB37.

UniProtKB/Swiss-Prot for RAB8B Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity).

Gene Wiki entry for RAB8B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB8B Gene

Genomics for RAB8B Gene

Regulatory Elements for RAB8B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAB8B Gene

Start:
63,189,469 bp from pter
End:
63,267,782 bp from pter
Size:
78,314 bases
Orientation:
Plus strand

Genomic View for RAB8B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB8B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB8B Gene

Proteins for RAB8B Gene

  • Protein details for RAB8B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92930-RAB8B_HUMAN
    Recommended name:
    Ras-related protein Rab-8B
    Protein Accession:
    Q92930
    Secondary Accessions:
    • Q5JPC4
    • Q9P293

    Protein attributes for RAB8B Gene

    Size:
    207 amino acids
    Molecular mass:
    23584 Da
    Quaternary structure:
    • Associated with actin, delta-catenin and alpha and beta tubulins (By similarity). Interacts with OTOF (By similarity). Interacts with PEX5R (By similarity). Interacts with RAB3IP. Interacts with VIM (By similarity). Interacts with CDH1 (By similarity). Interacts with MICALL2 (By similarity).

neXtProt entry for RAB8B Gene

Proteomics data for RAB8B Gene at MOPED

Post-translational modifications for RAB8B Gene

  • Ubiquitination at Lys100
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB8B Gene

No data available for DME Specific Peptides for RAB8B Gene

Domains for RAB8B Gene

Gene Families for RAB8B Gene

HGNC:
  • RAB :RAB, member RAS oncogene

Suggested Antigen Peptide Sequences for RAB8B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92930

UniProtKB/Swiss-Prot:

RAB8B_HUMAN :
  • Q92930
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB8B: view

Function for RAB8B Gene

Molecular function for RAB8B Gene

UniProtKB/Swiss-Prot Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity).

Gene Ontology (GO) - Molecular Function for RAB8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 9030196
GO:0005102 receptor binding IPI 18346465
GO:0005515 protein binding IPI 17646400
GO:0005525 GTP binding IEA --
GO:0019003 GDP binding IDA 20937701
genes like me logo Genes that share ontologies with RAB8B: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB8B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB8B Gene

Localization for RAB8B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB8B Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB8B Gene COMPARTMENTS Subcellular localization image for RAB8B gene
Compartment Confidence
peroxisome 5
plasma membrane 5
cytosol 3
mitochondrion 2
golgi apparatus 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RAB8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IEA --
GO:0005768 endosome IBA --
genes like me logo Genes that share ontologies with RAB8B: view

Pathways for RAB8B Gene

genes like me logo Genes that share pathways with RAB8B: view

Pathways by source for RAB8B Gene

Gene Ontology (GO) - Biological Process for RAB8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport --
GO:0006904 vesicle docking involved in exocytosis IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RAB8B: view

Compounds for RAB8B Gene

(2) Drugbank Compounds for RAB8B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Guanosine-5'-Diphosphate
146-91-8 target
Phosphoaminophosphonic Acid Guanylate Ester
target
genes like me logo Genes that share compounds with RAB8B: view

Transcripts for RAB8B Gene

Unigene Clusters for RAB8B Gene

RAB8B, member RAS oncogene family:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB8B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB8B Gene

No ASD Table

Relevant External Links for RAB8B Gene

GeneLoc Exon Structure for
RAB8B
ECgene alternative splicing isoforms for
RAB8B

Expression for RAB8B Gene

mRNA expression in normal human tissues for RAB8B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB8B Gene

This gene is overexpressed in Whole Blood (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB8B Gene

SOURCE GeneReport for Unigene cluster for RAB8B Gene Hs.389733

genes like me logo Genes that share expressions with RAB8B: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RAB8B Gene

Orthologs for RAB8B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB8B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB8B 35
  • 99.4 (n)
  • 100 (a)
RAB8B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB8B 35
  • 93.24 (n)
  • 98.07 (a)
RAB8B 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB8B 35
  • 89.86 (n)
  • 92.72 (a)
RAB8B 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab8b 35
  • 92.59 (n)
  • 98.55 (a)
Rab8b 16
Rab8b 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB8B 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB8B 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab8b 35
  • 93.56 (n)
  • 98.55 (a)
chicken
(Gallus gallus)
Aves RAB8B 35
  • 87.28 (n)
  • 96.62 (a)
RAB8B 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab8b 35
  • 80.03 (n)
  • 94.69 (a)
zebrafish
(Danio rerio)
Actinopterygii rab8b 35
  • 80.35 (n)
  • 94.2 (a)
rab8b 36
  • 93 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rab-8 36
  • 73 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC4 38
soybean
(Glycine max)
eudicotyledons Gma.11282 35
rice
(Oryza sativa)
Liliopsida Os07g0195100 35
  • 65.54 (n)
  • 63.84 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3970 35
Species with no ortholog for RAB8B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB8B Gene

ENSEMBL:
Gene Tree for RAB8B (if available)
TreeFam:
Gene Tree for RAB8B (if available)

Paralogs for RAB8B Gene

Paralogs for RAB8B Gene

Pseudogenes.org Pseudogenes for RAB8B Gene

genes like me logo Genes that share paralogs with RAB8B: view

Variants for RAB8B Gene

Sequence variations from dbSNP and Humsavar for RAB8B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs13681 -- 63,267,410(+) GTTAT(A/T)ATAGT utr-variant-3-prime
rs764090 -- 63,214,293(+) TTTTT(C/T)TTTTT intron-variant
rs894992 -- 63,208,463(-) AAAAA(A/T)TAGCA intron-variant
rs894993 -- 63,208,337(-) CATCA(A/T)CTCAG intron-variant
rs1017545 -- 63,261,795(-) AATCA(A/G)CCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB8B Gene

Variant ID Type Subtype PubMed ID
nsv428305 CNV Gain 18775914
esv27033 CNV Gain+Loss 19812545

Relevant External Links for RAB8B Gene

HapMap Linkage Disequilibrium report
RAB8B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB8B Gene

Disorders for RAB8B Gene

Relevant External Links for RAB8B

Genetic Association Database (GAD)
RAB8B
Human Genome Epidemiology (HuGE) Navigator
RAB8B
genes like me logo Genes that share disorders with RAB8B: view

No data available for UniProtKB/Swiss-Prot for RAB8B Gene

Publications for RAB8B Gene

  1. RAB GTPases expressed in human melanoma cells. (PMID: 9030196) Chen D. … Gahl W.A. (Biochim. Biophys. Acta 1997) 2 3 4
  2. A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport. (PMID: 12221131) Hattula K. … Peranen J. (Mol. Biol. Cell 2002) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form. (PMID: 18772196) Heidrych P. … Blin N. (Hum. Mol. Genet. 2008) 2 3

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