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RAB8B Gene

protein-coding   GIFtS: 55
GCID: GC15P063481

RAB8B, Member RAS Oncogene Family

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAB8B, Member RAS Oncogene Family1 2
RAB-8b Protein2
Ras-Related Protein Rab-8B2

External Ids:    HGNC: 302731   Entrez Gene: 517622   Ensembl: ENSG000001661287   OMIM: 6135325   UniProtKB: Q929303   

Export aliases for RAB8B gene to outside databases

Previous GC identifers: GC15P061197 GC15P061268 GC15P040304


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAB8B Gene:
RAB proteins, like RAB8B, are low molecular mass monomeric GTPases that localize on the cytoplasmic surfaces of
distinct membrane-bound organelles. RAB proteins function in intracellular vesicle transport by aiding in the
docking and/or fusion of vesicles with their target membranes (summary by Chen et al., 1997 (PubMed
9030196)).(supplied by OMIM, Nov 2010)

GeneCards Summary for RAB8B Gene:
RAB8B (RAB8B, member RAS oncogene family) is a protein-coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB10.

UniProtKB/Swiss-Prot: RAB8B_HUMAN, Q92930
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of
transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active
GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible
for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular
trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By
similarity)

Gene Wiki entry for RAB8B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAB8B gene promoter:
         GR   TBP   SRF   SRF (504 AA)   AP-2gamma   NF-kappaB   AREB6   TFIID   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB8B promoter sequence
   Search Chromatin IP Primers for RAB8B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAB8B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.2   Ensembl cytogenetic band:  15q22.2   HGNC cytogenetic band: 15q22

RAB8B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB8B gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P063481:  view genomic region     (about GC identifiers)

Start:
63,481,668 bp from pter      End:
63,559,981 bp from pter
Size:
78,314 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RAB8B_HUMAN, Q92930 (See protein sequence)
Recommended Name: Ras-related protein Rab-8B precursor  
Size: 207 amino acids; 23584 Da
Subunit: Associated with actin, delta-catenin and alpha and beta tubulins (By similarity). Interacts with OTOF (By
similarity). Interacts with PEX5R (By similarity). Interacts with RAB3IP. Interacts with VIM (By similarity).
Interacts with CDH1 (By similarity). Interacts with MICALL2 (By similarity)
Secondary accessions: Q5JPC4 Q9P293

Explore the universe of human proteins at neXtProt for RAB8B: NX_Q92930

Explore proteomics data for RAB8B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys100
  • Modification sites at PhosphoSitePlus

  • See RAB8B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057614.1  
    ENSEMBL proteins: 
     ENSP00000312734   ENSP00000453236   ENSP00000453679   ENSP00000453111   ENSP00000453982  
     ENSP00000405463  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q92930

    ProtoNet protein and cluster: Q92930

    1 Blocks protein domain: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RAB8B_HUMAN, Q92930
    Similarity: Belongs to the small GTPase superfamily. Rab family


    Find genes that share domains with RAB8B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAB8B_HUMAN, Q92930
    Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of
    transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active
    GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible
    for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular
    trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By
    similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS9030196
    GO:0005102receptor binding IPI18346465
    GO:0005515protein binding ----
    GO:0005525GTP binding IEA--
    GO:0019003GDP binding IDA--
         
    Find genes that share ontologies with RAB8B           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RAB8B

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    miRTarBase miRNAs that target RAB8B:
    hsa-mir-93-5p (MIRT048745), hsa-mir-215-5p (MIRT024415), hsa-mir-128-3p (MIRT021910), hsa-mir-101-3p (MIRT027257), hsa-mir-192-5p (MIRT026284), hsa-mir-361-5p (MIRT020088)

    Block miRNA regulation of human, mouse, rat RAB8B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAB8B (see all 127):
    hsa-miR-548j hsa-miR-3678-3p hsa-miR-300 hsa-miR-106a hsa-miR-15a hsa-miR-200a hsa-miR-519a hsa-miR-149
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RAB8B_HUMAN, Q92930: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cytoplasmic vesicle, phagosome.
    Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing
    S.aureus or M.tuberculosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome5
    plasma membrane5
    cytosol3
    mitochondrion2
    golgi apparatus1
    nucleus1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005778peroxisomal membrane IDA18346465

    Find genes that share ontologies with RAB8B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAB8B About    
    See pathways by source

    SuperPathContained pathways About
    1Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    Germ Cell-Sertoli Cell Junction Dynamics0.38

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RAB8B
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Germ Cell-Sertoli Cell Junction Dynamics



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RAB8B
    Interactions:

        Search GeneGlobe Interaction Network for RAB8B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAB8B (Q929303 ENSP000003127344) via UniProtKB, MINT, STRING, and/or I2D (see all 115)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000232575P074373, ENSP000004100714I2D: score=1 STRING: ENSP00000410071
    ENSG00000183311P074373I2D: score=1 
    ENSG00000224156P074373I2D: score=1 
    ENSG00000227739P074373I2D: score=1 
    ENSG00000229684P074373I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process NAS9030196
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--

    Find genes that share ontologies with RAB8B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for RAB8B

    2 DrugBank Compounds for RAB8B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Diphosphate-- 146-91-8target--17139284 17016423 10592235
    Phosphoaminophosphonic Acid Guanylate Ester-- --target--17139284 17016423 10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RAB8B gene: 
    NM_016530.2  

    Unigene Cluster for RAB8B:

    RAB8B, member RAS oncogene family
    Hs.389733  [show with all ESTs]
    Unigene Representative Sequence: NM_016530
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000321437(uc002alz.3 uc010uih.2) ENST00000558990 ENST00000558119
    ENST00000559927 ENST00000559006 ENST00000448330
    miRNA
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    hsa-miR-548j hsa-miR-3678-3p hsa-miR-300 hsa-miR-106a hsa-miR-15a hsa-miR-200a hsa-miR-519a hsa-miR-149
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    Additional mRNA sequence: 

    AB038995.1 AK001111.1 AK095444.1 AK297598.1 AL133607.1 AL713722.1 AL833365.1 BC020654.1 
    U66624.1 

    8 DOTS entries:

    DT.107660  DT.100796552  DT.95290899  DT.100796557  DT.100705723  DT.100796553  DT.100796554  DT.95139038 

    Selected AceView cDNA sequences (see all 209):

    BU542886 AA367158 CB960874 BQ708432 AL133607 T10792 CA454266 AI610982 
    AI206228 AA362265 AW503673 N34690 BU632165 BQ719944 AB038995 AI692886 
    CF994911 AI018689 BM676020 T10520 BM712496 BF969630 NM_016530 U66624 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAB8B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTTAATCT
    RAB8B Expression
    About this image


    RAB8B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
    RAB8B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAB8B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.389733
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAB8B gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab8b1 , 5 RAB8B, member RAS oncogene family1, 5 92.59(n)1
    98.55(a)1
      9 (36.17 cM)5
    2354421  NM_173413.31  NP_775589.11 
     668436725 
    chicken
    (Gallus gallus)
    Aves RAB8B1 RAB8B, member RAS oncogene family 87.28(n)
    96.62(a)
      415371  XM_004943742.1  XP_004943799.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rab8b1 RAB8B, member RAS oncogene family 80.03(n)
    94.69(a)
      100036650  NM_001097208.1  NP_001090677.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rab8b1 RAB8B, member RAS oncogene family 80.35(n)
    94.2(a)
      100093706  NM_001099259.1  NP_001092729.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rab-86
    Protein RAB-8 (rab-8) mRNA, complete cds
    73(a)
    1 ↔ 1
    I(3682893-3684118) WBGene00004272
    soybean
    (Glycine max)
    eudicotyledons Gma.112822 Transcribed sequence with strong similarity to protein more 71.03(n)  
    rice
    (Oryza sativa)
    Liliopsida AK104346.12   -- 72.37(n)    AK104346.1 


    ENSEMBL Gene Tree for RAB8B (if available)
    TreeFam Gene Tree for RAB8B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAB8B gene
    RAB102  RAB3B2  RAB262  RAB8A2  RAB3D2  RAB372  RAB3A2  RAB1B2  
    RAB122  RAB1A2  RAB132  RAB3C2  
    Selected SIMAP similar genes for RAB8B using alignment to 6 protein entries:     RAB8B_HUMAN (see all proteins) (see all similar genes):
    RAB8A    RAB10    rab1b    RAB13    RAB3C    RAB3A
    DKFZp686J06205    RAB1C    RAB3D    RAB15    RAB1A    RAB3B
    DKFZp686J07132    RAB35    RAB43    RAB1B    RAB30    RAB19

    Find genes that share paralogs with RAB8B           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RAB8B
    PGOHUM00000262037


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAB8B (see all 1601)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1442953411,2
    --63479768(+) TTTTTA/GAAAAG 1 -- us2k10--------
    rs1487400201,2
    C--63479825(+) AGGAAC/TGAGGA 1 -- us2k10--------
    rs1924006721,2
    --63479920(+) GGCTCA/GGCCTG 1 -- us2k10--------
    rs349605421,2
    C,F--63479962(+) GCAGAC/TACTGT 1 -- us2k18Minor allele frequency- T:0.17NA WA EA 546
    rs1832490171,2
    --63479993(+) TTTGTC/TCCTAT 1 -- us2k10--------
    rs1161120211,2
    C,F--63480010(+) GACTCT/AAGGAA 1 -- us2k11Minor allele frequency- A:0.10WA 118
    rs1422883041,2
    C--63480213(+) ACACAG/TTATGT 1 -- us2k10--------
    rs2001507731,2
    --63480265(+) GGTTT-/CTTCCC 1 -- us2k10--------
    rs1814336511,2
    C--63480266(+) GGTTTC/TTCCCC 1 -- us2k10--------
    rs339601851,2
    C,F--63480268(+) TTTTTC/TCCCCC 1 -- us2k12Minor allele frequency- T:0.50NA 4

    HapMap Linkage Disequilibrium report for RAB8B (63481668 - 63559981 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RAB8B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv428305CNV Gain18775914
    esv27033CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613532    OMIM disorders: --


    Find genes that share disorders with RAB8B           About GenesLikeMe

    Genetic Association Database (GAD): RAB8B
    Human Genome Epidemiology (HuGE) Navigator: RAB8B (1 document)

    Export disorders for RAB8B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAB8B gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with RAB8B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RAB GTPases expressed in human melanoma cells. (PubMed id 9030196)1, 2, 3 Chen D.... Gahl W.A. (Biochim. Biophys. Acta 1997)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form. (PubMed id 18772196)1, 3 Heidrych P....Blin N. (Hum. Mol. Genet. 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport. (PubMed id 12221131)1, 2 Hattula K.... Peranen J. (Mol. Biol. Cell 2002)
    7. SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. (PubMed id 23246001)1 Xu Y....Ye Y. (Cell Rep 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (J Proteomics 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51762 HGNC: 30273 AceView: RAB8B Ensembl:ENSG00000166128 euGenes: HUgn51762
    ECgene: RAB8B H-InvDB: RAB8B

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RAB8B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB8B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAB8B gene:
    Search GeneIP for patents involving RAB8B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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