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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB8A Gene

protein-coding   GIFtS: 60
GCID: GC19P016222

RAB8A, member RAS oncogene family

(Previous name: mel transforming oncogene (derived from cell line NK14)...)
(Previous symbol: MEL)
 Explore 14 diseases affiliated with
RAB8A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RAB8A    

Aliases
for RAB8A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
RAB8A, Member RAS Oncogene Family1 2     Mel Transforming Oncogene (Derived From Cell Line NK14)- RAB8 Homolog2
MEL1 2 3 5     Mel Transforming Oncogene (RAB8 Homolog)2
RAB81 2 3     Ras-Associated Protein RAB82
Mel Transforming Oncogene (Derived From Cell Line NK14)1 2     Ras-Related Protein Rab-8A2
Oncogene C-Mel2 3     

External Ids:    HGNC: 70071   Entrez Gene: 42182   Ensembl: ENSG000001674617   OMIM: 1650405   UniProtKB: P610063   

Export aliases for RAB8A gene to outside databases

Previous GC identifers: GC19P016083 GC19P015793


Summaries
for RAB8A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RAB8A:
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an
average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of
proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51%
similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding
sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that
of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS
superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated
as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable.
This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RAB8A_HUMAN, P61006
Function: May be involved in vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the
exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation
sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial
cell polarization

Gene Wiki entry for RAB8A


Genomic Views
for RAB8A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB8A gene promoter:
         AP-1   ATF-2   c-Jun   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAB8A promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB8A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB8A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.2-p13.1

RAB8A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB8A gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P016222:  view genomic region     (about GC identifiers)

Start:
 16,222,439 bp from pter      End:
 16,245,044 bp from pter
Size:
 22,606 bases      Orientation:
 plus strand

Proteins
for RAB8A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RAB8A_HUMAN, P61006 (See protein sequence)
Recommended Name: Ras-related protein Rab-8A precursor  
Size: 207 amino acids; 23668 Da
Subunit: Interacts with MAP4K2 and SYTL4. Interacts with SGSM1 and SGSM3 (By similarity). Interacts with RABIF, RIMS2,
RPH3A and RPH3A (By similarity). Interacts with OPTN. Interacts with RAB3IP. Interacts with MYO5B. Interacts with
PIFO. Interacts with BIRC6/bruce. Interacts with OCRL
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Golgi apparatus. Cytoplasm,
perinuclear region. Cell projection. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane;
Lipid-anchor; Cytoplasmic side (By similarity). Note=Colocalizes with OPTN at the Golgi complex and in vesicular
structures close to the plasma membrane. In the GDP-bound form, present in the perinuclear region. Shows a polarized
distribution to distal regions of cell protrusions in the GTP-bound form. Colocalizes with PARD3, PRKCI, EXOC5, OCLN,
PODXL and RAB11A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis.
Recruited to phagosomes containing S.aureus or M.tuberculosis
2 PDB 3D structures from and Proteopedia for RAB8A:
3QBT (3D)        3TNF (3D)    
Secondary accessions: P24407 Q6FHV5

Explore the universe of human proteins at neXtProt for RAB8A: NX_P61006

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P61006

    • RAB8A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005361.2  
    ENSEMBL proteins: 
     ENSP00000300935   ENSP00000467501  
    Reactome Protein details: P61006
    Human Recombinant Protein Products: 
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    Uscn Proteins for RAB8A

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IEA--
    GO:0005886plasma membrane IEA--
    GO:0005932microtubule basal body IEA--
    GO:0014069postsynaptic density IEA--
    GO:0030670phagocytic vesicle membrane IEA--


    RAB8A for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RAB8A

    Protein Domains /
    Families
    for RAB8A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RAB8A for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type

    Graphical View of Domain Structure for InterPro Entry P61006

    ProtoNet protein and cluster: P61006

    5 Blocks protein families:
    IPB001806 Transforming protein P21 RAS signature
    IPB002041 GTP-binding nuclear protein Ran
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase
    IPB006688 ADP-ribosylation factor


    UniProtKB/Swiss-Prot: RAB8A_HUMAN, P61006
    Similarity: Belongs to the small GTPase superfamily. Rab family


    Function
    for RAB8A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RAB8A_HUMAN, P61006
    Function: May be involved in vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the
    exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation
    sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial
    cell polarization

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    hsa-miR-302d hsa-miR-520e hsa-miR-30d hsa-miR-519a hsa-miR-218 hsa-miR-372 hsa-miR-30a hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmid: RAB8A 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0005525GTP binding IDA--
    GO:0017137Rab GTPase binding ISS--
    GO:0019003GDP binding IDA--
    GO:0019901protein kinase binding IEA--


    RAB8A for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for RAB8A:
     Decreased Hepatitis C virus re 

    Animal Models:
         Mouse knock-out Rab8atm1.2Aha for RAB8A
         7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Rab8a):
     cellular  digestive/alimentary  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     mortality/aging  renal/urinary system 

    RAB8A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RAB8A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell Cycle
    		Cell Cycle1.00
    		Cell Cycle, Mitotic0.84
    2Membrane Trafficking
    		Membrane Trafficking1.00
    		Translocation of GLUT4 to the Plasma Membrane0.32
    3Clathrin-dependent protein traffic
    		Clathrin-dependent protein traffic1.00
    		Transport_Clathrin-coated vesicle cycle0.66
    4Recruitment of mitotic centrosome proteins and complexes
    		G2/M Transition0.83
    		Mitotic G2-G2/M phases0.81
    5Cytoskeletal Signaling
    		Cytoskeletal Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for RAB8A
        Clathrin-dependent protein traffic

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB8A
        Epithelial Tight Junctions

    1 Cell Signaling Technology (CST) Pathway for RAB8A
        Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for RAB8A
        Transport Clathrin-coated vesicle cycle

    5/7        Reactome Pathways for RAB8A (see all 7)
        Membrane Trafficking
    G2/M Transition
    Cell Cycle
    Translocation of GLUT4 to the Plasma Membrane
    Mitotic G2-G2/M phases


    1         Kegg Pathway  (Kegg details for RAB8A):
        Pancreatic secretion


    RAB8A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB8A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/41 Interacting proteins for RAB8A (P610062, 3 ENSP000003009354) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OCRLQ019682, 3, ENSP000003601544MINT-2882797 MINT-8184851 MINT-8184763 MINT-8184836 MINT-8185021 MINT-8184863 MINT-8184983 MINT-2882984 MINT-8184736 MINT-8184949 MINT-8184748 MINT-2883154 I2D: score=2 STRING: ENSP00000360154
    RABIFP472242, 3, ENSP000003562314MINT-2837574 MINT-2837552 I2D: score=2 STRING: ENSP00000356231
    BAG6P463792, 3MINT-63929 I2D: score=5 
    RIMS2Q9UQ263, ENSP000003862284I2D: score=5 STRING: ENSP00000390665 STRING: ENSP00000386228
    PQBP1O608282, 3, ENSP000003657474MINT-63180 I2D: score=4 STRING: ENSP00000365747
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006904vesicle docking involved in exocytosis IDA17574030
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0007409axonogenesis ISS--
    GO:0015031protein transport IEA--
    GO:0042384cilium assembly IDA17574030


    RAB8A for ontologies           About GeneDecksing



    Drugs & Compounds
    for RAB8A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RAB8A
    Search CenterWatch for drugs/clinical trials and news about RAB8A 

    Transcripts
    for RAB8A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RAB8A gene: 
    NM_005370.4  

    Unigene Cluster for RAB8A:

    RAB8A, member RAS oncogene family
    Hs.642874  [show with all ESTs]
    Unigene Representative Sequence: AK095221
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300935(uc002ndm.1 uc002ndn.4 uc010xpc.2 uc002ndo.4)
    ENST00000590899 ENST00000588105 ENST00000587156 ENST00000586682 ENST00000589697
    ENST00000592971

    miRNA
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    hsa-miR-302d hsa-miR-520e hsa-miR-30d hsa-miR-519a hsa-miR-218 hsa-miR-372 hsa-miR-30a hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmid: RAB8A 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB209767.1 AF498943.1 AK025165.1 AK095221.1 AK293676.1 AY927516.1 BC002977.1 BT007184.1 
    CR536583.1 CR542274.1 X56741.1 

    23 DOTS entries:

    DT.100826418  DT.448409  DT.100826438  DT.100826413  DT.92451995  DT.95213985  DT.100826414  DT.95254275 
    DT.99936169  DT.100826416  DT.100826440  DT.121446010  DT.121446021  DT.100826417  DT.121445967  DT.121445969 
    DT.121445993  DT.40267899  DT.95368091  DT.95368097  DT.97811779  DT.100826419  DT.92452006 

    24/536 AceView cDNA sequences (see all 536):

    BQ892283 BM457602 BQ070820 BQ083814 AI126505 BP365166 AI499265 CR542274 
    CR594350 BQ055957 BE301626 BC025237 BM916405 BQ233493 BM824094 BE018144 
    CR597154 BP352452 AF498943 BM464622 BQ671010 BQ674769 H77453 AA328139 

    GeneLoc Exon Structure


    Expression
    for RAB8A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB8A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTCTGTTTAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See RAB8A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAB8A

    SOURCE GeneReport for Unigene cluster: Hs.642874
        SABiosciences Custom PCR Arrays for RAB8A
    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for RAB8A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAB8A gene from 8/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RAB8A1 RAB8A, member RAS oncogene family 83.74(n)
    93.72(a)    		   428352  NM_001031504.1  NP_001026675.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RAB8A6
    		 --
    		 69(a)
    		 1 ↔ 1
    		 AAWZ02037377(4297-13626)
    African clawed frog
    (Xenopus laevis)    		 Amphibia CA788377.12   -- 80.43(n)    CA788377.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii rab8a1 RAB8A, member RAS oncogene family 79.55(n)
    93.24(a)    		   571897  NM_001089562.1  NP_001083031.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Rab81 Rab-protein 8 74.56(n)
    79.23(a)    		   40168  NM_079448.3  NP_524172.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea rab-81 Protein RAB-8 67.66(n)
    74.26(a)    		   171935  NM_058798.4  NP_491199.2 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons RAB8A6
    AT5G598406
    (see all 5)    		 Ras-related protein Rab-8A
    (see all 5)    		 60(a)
    60(a)
    (see all 5)    		 possible ortholog
    possible ortholog
    (see all 5)    		 3(16917589-16920018)
    5(24107215-24109251)
    rice
    (Oryza sativa)    		 Liliopsida Os07g01951001 hypothetical protein 61.41(n)
    62.5(a)    		   4342644  NM_001065650.1  NP_001059115.1 


    ENSEMBL Gene Tree for RAB8A (if available)
    TreeFam Gene Tree for RAB8A (if available) 

    Paralogs
    for RAB8A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAB8A gene
    RAB102  RAB192  RAB432  RAB182  RAB262  RAB372  RAB352  RAB8B2  
    RAB1B2  RAB122  RAB302  RAB1A2  RAB132  
    18/105 SIMAP similar genes for RAB8A using alignment to 2 protein entries:     RAB8A_HUMAN (see all proteins) (see all similar genes):
    RAB8B    rab1b    RAB10    DKFZp686J06205    RAB13    RAB3C
    RAB43    DKFZp686J07132    RAB3B    RAB15    RAB19    RAB12
    RAB1C    RAB3A    RAB35    RAB30    DKFZp313C1541    RAB26

    RAB8A for paralogs           About GeneDecksing



    Genomic Variants
    for RAB8A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/410 NCBI SNPs in RAB8A are shown (see all 410)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1997986921,2
    		C--15814361(+) CGACCA/CCAGCC 1 -- us2k10--------
    rs11377901,2
    		--15815877(+) aaaggG/Caaaag 1 -- ut512Minor allele frequency- C:0.00MN NA 186
    rs1385427431,2
    		--16220568(+) CAGCCA/GCCTGA 1 -- us2k10--------
    rs288416731,2
    		C,--16220643(+) TGTTTC/TACCAT 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs2017635491,2
    		--16220688(+) GTGAT-/CCACCT 1 -- us2k10--------
    rs1462030731,2
    		--16220786(+) TTGCTA/GTGTTG 1 -- us2k10--------
    rs129836531,2
    		C,F,--16220893(+) TTTATT/CTGTTG 1 -- us2k16Minor allele frequency- C:0.15NA WA EA 366
    rs1484343961,2
    		--16221257(+) TGTTTC/TTAGTA 1 -- us2k10--------
    rs1419192711,2
    		--16221279(+) TCACCG/TCGTTA 1 -- us2k10--------
    rs1506686961,2
    		--16221280(+) CACCGC/TGTTAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAB8A (16222439 - 16245044 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RAB8A: --

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    Disorders / Diseases
    for RAB8A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RAB8A for disorders           About GeneDecksing

    OMIM gene information: 165040    OMIM disorders: --

    14 diseases for RAB8A:    About MalaCards
    open-angle glaucoma    melanoma    primary open angle glaucoma    bardet-biedl syndrome
    sphingolipidosis    glaucoma    retinitis pigmentosa    insulin resistance
    retinal degeneration    hepatitis b    retinitis    hepatitis
    cholesterol    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for RAB8A:
    Melanoma
    Human Genome Epidemiology (HuGE) Navigator: RAB8A (1 document)

    Export disorders for RAB8A gene to outside databases

    Publications
    for RAB8A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB8A gene, integrated from 9 sources (see all 73):
    (articles sorted by number of sources associating them with RAB8A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The MEL gene: a new member of the RAB/YPT class of RAS-related genes. (PubMed id 1886711)1, 2, 3, 9 Nimmo E.R....Johnson K.J. (1991)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis. (PubMed id 15837803)1, 2 Sahlender D.A....Buss F. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport. (PubMed id 12221131)1, 2 Hattula K....Peranen J. (2002)
    6. A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells. (PubMed id 8294494)1, 2 Zahraoui A.... Louvard D. (1994)
    7. Rab8, a small GTPase involved in vesicular traffic be tween the TGN and the basolateral plasma membrane. (PubMed id 8408203)1, 3 Huber L.A....Simons K. (1993)
    8. Isoprenylation of Rab proteins possessing a C-terminal CaaX motif. (PubMed id 8375503)1, 2 Joberty G.... Zahraoui A. (1993)
    9. In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase. (PubMed id 8643544)1, 9 Ren M....Sabatini D.D. (1996)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    External Searches for RAB8A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing RAB8A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4218 HGNC: 7007 AceView: RAB8AandHSH2D Ensembl:ENSG00000167461 euGenes: HUgn4218
    ECgene: RAB8A Kegg: 4218 H-InvDB: RAB8A

    Other Databases showing RAB8A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RAB8A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB8A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB8A Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RAB8A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RAB8A gene:
    Search GeneIP for patents involving RAB8A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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