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Aliases for RAB7B Gene

Aliases for RAB7B Gene

  • RAB7B, Member RAS Oncogene Family 2 3
  • Ras-Related Protein Rab-7b 3
  • Ras-Related Protein Rab-7 3
  • RAB7 3

External Ids for RAB7B Gene

Summaries for RAB7B Gene

GeneCards Summary for RAB7B Gene

RAB7B (RAB7B, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB7B include hiv-1. Among its related pathways are Amoebiasis and Salmonella infection (KEGG). GO annotations related to this gene include GTP binding.

UniProtKB/Swiss-Prot for RAB7B Gene

  • Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.

Gene Wiki entry for RAB7B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB7B Gene

Genomics for RAB7B Gene

Genomic Location for RAB7B Gene

Start:
205,976,740 bp from pter
End:
206,003,466 bp from pter
Size:
26,727 bases
Orientation:
Minus strand

Genomic View for RAB7B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB7B Gene

No data available for Regulatory Elements for RAB7B Gene

Proteins for RAB7B Gene

  • Protein details for RAB7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AH8-RAB7B_HUMAN
    Recommended name:
    Ras-related protein Rab-7b
    Protein Accession:
    Q96AH8
    Secondary Accessions:

    Protein attributes for RAB7B Gene

    Size:
    199 amino acids
    Molecular mass:
    22511 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RAB7B Gene

Proteomics data for RAB7B Gene at MOPED

Post-translational modifications for RAB7B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB7B Gene

No data available for DME Specific Peptides for RAB7B Gene

Domains for RAB7B Gene

Gene Families for RAB7B Gene

HGNC:
  • RAB :RAB, member RAS oncogene

UniProtKB/Swiss-Prot:

RAB7B_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rab family.:
    • Q96AH8
genes like me logo Genes that share domains with RAB7B: view

Function for RAB7B Gene

Molecular function for RAB7B Gene

UniProtKB/Swiss-Prot Function: Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.

Gene Ontology (GO) - Molecular Function for RAB7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB7B: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RAB7B Gene

Localization for RAB7B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB7B Gene

Late endosome. Lysosome. Golgi apparatus, trans-Golgi network. Golgi apparatus. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.

Gene Ontology (GO) - Cellular Components for RAB7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005764 lysosome IDA 20375062
GO:0005770 late endosome IDA 20375062
genes like me logo Genes that share ontologies with RAB7B: view

Pathways for RAB7B Gene

genes like me logo Genes that share pathways with RAB7B: view

Pathways by source for RAB7B Gene

3 KEGG pathways for RAB7B Gene

Interacting Proteins for RAB7B Gene

Gene Ontology (GO) - Biological Process for RAB7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with RAB7B: view

Transcripts for RAB7B Gene

mRNA/cDNA for RAB7B Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB7B Gene

RAB7B, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB7B Gene

No ASD Table

Relevant External Links for RAB7B Gene

GeneLoc Exon Structure for
RAB7B
ECgene alternative splicing isoforms for
RAB7B

Expression for RAB7B Gene

mRNA expression in normal human tissues for RAB7B Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RAB7B Gene

SOURCE GeneReport for Unigene cluster for RAB7B Gene Hs.534612

mRNA Expression by UniProt/SwissProt for RAB7B Gene

Q96AH8-RAB7B_HUMAN
Tissue specificity: Expressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte.
genes like me logo Genes that share expressions with RAB7B: view

Orthologs for RAB7B Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAB7B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB7B 36
  • 99.04 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia RAB7B 36
  • 86.6 (n)
  • 89.45 (a)
dog
(Canis familiaris)
Mammalia LOC488576 36
  • 88.78 (n)
  • 93.47 (a)
mouse
(Mus musculus)
Mammalia 5430435G22Rik 36
  • 85.43 (n)
  • 88.44 (a)
rat
(Rattus norvegicus)
Mammalia Rab7b 36
  • 85.09 (n)
  • 89.95 (a)
chicken
(Gallus gallus)
Aves LOC771782 36
  • 73.53 (n)
  • 71.86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab7b 36
  • 62.98 (n)
  • 61.31 (a)
Species with no ortholog for RAB7B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RAB7B Gene

ENSEMBL:
Gene Tree for RAB7B (if available)
TreeFam:
Gene Tree for RAB7B (if available)

Paralogs for RAB7B Gene

genes like me logo Genes that share paralogs with RAB7B: view

No data available for Paralogs for RAB7B Gene

Variants for RAB7B Gene

Relevant External Links for RAB7B Gene

HapMap Linkage Disequilibrium report
RAB7B

No data available for Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for RAB7B Gene

Disorders for RAB7B Gene

(1) MalaCards Diseases for RAB7B Gene

Search for RAB7B Gene in MalaCards »
genes like me logo Genes that share disorders with RAB7B: view

No data available for UniProtKB/Swiss-Prot for RAB7B Gene

Publications for RAB7B Gene

  1. Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells. (PMID: 15144907) Yang M. … Cao X. (Biochem. Biophys. Res. Commun. 2004) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Small Rab GTPase Rab7b promotes megakaryocytic differentiation by enhancing IL-6 production and STAT3-GATA-1 association. (PMID: 20953574) He D. … Cai Z. (J. Mol. Med. 2011) 3 4
  4. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PMID: 21255211) Seto S. … Koide Y. (Traffic 2011) 3 4
  5. Rab7b controls trafficking from endosomes to the TGN. (PMID: 20375062) Progida C. … Bucci C. (J. Cell Sci. 2010) 3 4

Products for RAB7B Gene

Sources for RAB7B Gene

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