Aliases for RAB7A Gene
Aliases for RAB7A Gene
External Ids for RAB7A Gene
- HGNC: 9788
- Entrez Gene: 7879
- Ensembl: ENSG00000075785
- OMIM: 602298
- UniProtKB: P51149
Previous HGNC Symbols for RAB7A Gene
- RAB7
Previous GeneCards Identifiers for RAB7A Gene
- GC03P129928
- GC03P128444
- GC03P125832
Summaries for RAB7A Gene
-
RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008]
GeneCards Summary for RAB7A Gene
RAB7A (RAB7A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB7A include Charcot-Marie-Tooth Disease, Axonal, Type 2B and Vici Syndrome. Among its related pathways are Mitophagy - animal and wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF). Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB9B.
UniProtKB/Swiss-Prot for RAB7A Gene
-
Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
Additional gene information for RAB7A Gene
- Monarch Initiative
- Search for RAB7A at DataMed
- Search for RAB7A at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB7A Gene
Genomics for RAB7A Gene
GeneHancer (GH) Regulatory Elements for RAB7A Gene
Regulatory Element Products
Genomic Locations for RAB7A Gene
- chr3:128,726,122-128,814,798
- (GRCh38/hg38)
- Size:
- 88,677 bases
- Orientation:
- Plus strand
- chr3:128,444,965-128,533,641
- (GRCh37/hg19)
Genomic View for RAB7A Gene
- Cytogenetic band:
-
- 3q21.3 by Ensembl
- 3q21.3 by Entrez Gene
- 3q21.3 by HGNC


RefSeq DNA sequence for RAB7A Gene
Proteins for RAB7A Gene
-
Protein details for RAB7A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P51149-RAB7A_HUMAN
- Recommended name:
- Ras-related protein Rab-7a
- Protein Accession:
- P51149
- A8K3V6
- Q9NWJ0
- Q9UPB0
Protein attributes for RAB7A Gene
- Size:
- 207 amino acids
- Molecular mass:
- 23490 Da
- Quaternary structure:
-
- The GTP-bound form interacts with RAC1 (By similarity). Interacts with NTRK1/TRKA (By similarity). Interacts with C9orf72 (By similarity). Interacts with CHM, the substrate-binding subunit of the Rab geranylgeranyltransferase complex (By similarity). Interacts with RILP (PubMed:11179213, PubMed:14668488, PubMed:15933719, PubMed:20028791, PubMed:22431521). Interacts with PSMA7 (PubMed:14998988). Interacts with RNF115 (PubMed:16925951). Interacts with FYCO1 (PubMed:20100911). Interacts with the PIK3C3/VPS34-PIK3R4 complex (PubMed:14617358). The GTP-bound form interacts with OSBPL1A (PubMed:16176980). Interacts with CLN3 (PubMed:22261744). Does not interact with HPS4 and the BLOC-3 complex (heterodimer of HPS1 and HPS4) (PubMed:20048159). Interacts with CLN5 (PubMed:22431521). Interacts with PLEKHM1 (via N- and C-terminus) (By similarity).
- SequenceCaution:
-
- Sequence=BAA91390.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAF83410.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=EAW79303.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for RAB7A Gene
Post-translational modifications for RAB7A Gene
- Ubiquitination at isoforms=32, isoforms=38, Lys126, isoforms=146, and Lys191
Other Protein References for RAB7A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for RAB7A (Rab7a)
- Cell Signaling Technology (CST) Antibodies for RAB7A (Rab7)
- Novus Biologicals Antibodies for RAB7A
-
Abcam antibodies for RAB7A
- Invitrogen Antibodies for RAB7A
- antibodies-online: Search results for 34 available RAB7A Antibodies ranked by validation data
- Compare Top RAB7A Antibodies
-
Recommended
- 1 IHC Antibody (anti-rat)
- 5 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 20 WB Antibodies (anti-human)
- 1 IHC Antibody (anti-mouse)
- 6 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-rat)
- 5 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 20 WB Antibodies (anti-human)
- 1 IHC Antibody (anti-mouse)
- 6 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- GeneTex RAB7A antibody for RAB7A
-
Santa Cruz Biotechnology (SCBT) Antibodies for RAB7A
- Sino Biological Antibodies for RAB7A
Protein Products
-
OriGene Purified Proteins for RAB7A
- Search Origene for MassSpec and Protein Over-expression Lysates for RAB7A
- Origene Custom Protein Services for RAB7A
- Sino Biological Recombinant Proteins for RAB7A
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for RAB7A
- GeneTex Proteins for RAB7A
-
Abcam proteins for RAB7A
Assay Products
-
Cloud-Clone Corp. Assay Kits for RAB7A
No data available for DME Specific Peptides for RAB7A Gene
Domains & Families for RAB7A Gene
Gene Families for RAB7A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for RAB7A Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for RAB7A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P51149- Family:
-
- Belongs to the small GTPase superfamily. Rab family.
Function for RAB7A Gene
Molecular function for RAB7A Gene
- UniProtKB/Swiss-Prot Function:
- Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
Phenotypes From GWAS Catalog for RAB7A Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003924 | GTPase activity | IEA,IDA | 18272684 |
GO:0005515 | protein binding | IPI | 14617358 |
GO:0005525 | GTP binding | IDA,IEA | 18272684 |
GO:0019003 | GDP binding | IEA,IDA | 18272684 |
Phenotypes for RAB7A Gene
- MGI mutant phenotypes for RAB7A:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for RAB7A:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased Salmonella enterica Typhimurium invasion
- Decreased Salmonella enterica Typhimurium effector injection
- Decreased shRNA abundance (Z-score < -2)
- Decreased Hepatitis C virus replication
- Decreased Salmonella-containing vacuole maturation
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RAB7A
-
-
ViGene Biosciences lentiviral particle packaged cDNA for RAB7A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RAB7A gene
- Search ViGene Biosciences for RAB7A
CRISPR Products
-
OriGene CRISPR knockouts for RAB7A
- genomics-online: gRNA clones - Search results for available RAB7A gene related products
- Applied Biological Materials CRISPR for RAB7A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RAB7A
- GenScript: Design CRISPR guide RNA sequences for RAB7A
miRNA for RAB7A Gene
- miRTarBase miRNAs that target RAB7A
-
- hsa-mir-324-3p (MIRT042998)
- hsa-mir-299-3p (MIRT120371)
- hsa-mir-6748-5p (MIRT120384)
- hsa-mir-6759-5p (MIRT120386)
- hsa-mir-6847-3p (MIRT120390)
- hsa-mir-6881-5p (MIRT484426)
- hsa-mir-6835-5p (MIRT484427)
- hsa-mir-6883-5p (MIRT484428)
- hsa-mir-6785-5p (MIRT484429)
- hsa-mir-4728-5p (MIRT484430)
- hsa-mir-149-3p (MIRT484431)
- hsa-mir-6739-5p (MIRT484432)
- hsa-mir-6733-5p (MIRT484433)
- hsa-mir-6797-5p (MIRT484434)
- hsa-mir-3153 (MIRT484435)
- hsa-mir-1249-5p (MIRT484436)
- hsa-mir-6133 (MIRT484437)
- hsa-mir-6130 (MIRT484438)
- hsa-mir-6129 (MIRT484439)
- hsa-mir-6127 (MIRT484440)
- hsa-mir-4510 (MIRT484441)
- hsa-mir-4419a (MIRT484442)
- hsa-mir-5681a (MIRT484443)
- hsa-mir-6783-5p (MIRT484444)
- hsa-mir-4756-5p (MIRT484445)
- hsa-mir-4739 (MIRT484446)
- hsa-mir-1321 (MIRT484447)
- hsa-mir-4779 (MIRT484448)
- hsa-mir-6891-5p (MIRT484449)
- hsa-mir-3173-3p (MIRT484450)
- hsa-mir-561-5p (MIRT490712)
- hsa-mir-6830-5p (MIRT490713)
- hsa-mir-2355-3p (MIRT606847)
- hsa-mir-676-3p (MIRT606848)
- hsa-mir-5590-5p (MIRT606849)
- hsa-mir-3124-5p (MIRT606850)
- hsa-mir-6793-5p (MIRT606851)
- hsa-mir-4437 (MIRT606852)
- hsa-mir-5580-5p (MIRT606853)
- hsa-mir-6882-3p (MIRT606854)
- hsa-mir-6817-5p (MIRT606855)
- hsa-mir-4769-3p (MIRT606856)
- hsa-mir-6893-3p (MIRT606857)
- hsa-mir-370-3p (MIRT606858)
- hsa-mir-3607-5p (MIRT606859)
- hsa-mir-3614-3p (MIRT741652)
miRNA Products
- Search ViGene Biosciences for RAB7A
Inhibitory RNA Products
- Origene shrna, RNAi, and sirna products in human, mouse, rat for RAB7A
- Browse OriGene Inhibitory RNA Products For RAB7A
- genomics-online: shRNA clones - Search results for available RAB7A gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RAB7A gene
Clone Products
- Sino Biological Human cDNA Clone for RAB7A
- Sino Biological Human cDNA Clone for RAB7A
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for RAB7A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RAB7A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RAB7A
- genomics-online: cdna clones - Search results for available RAB7A gene related products
- orf clones - Search results for available RAB7A gene related products
- Applied Biological Materials Clones for RAB7A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for RAB7A
-
ViGene Biosciences adenoviral particle packaged cDNA for RAB7A gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RAB7A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RAB7A gene
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for RAB7A Gene
Localization for RAB7A Gene
Subcellular locations from UniProtKB/Swiss-Prot for RAB7A Gene
- Cytoplasmic vesicle, phagosome membrane; Peripheral membrane protein; Cytoplasmic side. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Melanosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet. Endosome membrane. Note=Colocalizes with OSBPL1A at the late endosome (PubMed:16176980). Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts. Recruited to phagosomes containing S.aureus or Mycobacterium (PubMed:21255211). Lipid droplet localization is increased upon ADRB2 stimulation (By similarity). {ECO:0000250 UniProtKB:P51150, ECO:0000269 PubMed:16176980, ECO:0000269 PubMed:21255211}.
- Lysosomes (3)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000421 | autophagosome membrane | IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005764 | colocalizes_with lysosome | IEA,IDA | 18272684 |
GO:0005765 | lysosomal membrane | TAS | -- |
GO:0005768 | endosome | IEA | -- |
Pathways & Interactions for RAB7A Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | Vesicle-mediated transport | ||
3 | Metabolism of proteins | ||
4 | Delta508-CFTR traffic / Sorting endosome formation in CF | ||
5 | Delta508-CFTR traffic / ER-to-Golgi in CF |
Pathways by source for RAB7A Gene
1 Cell Signaling Technology pathway for RAB7A Gene
1 BioSystems pathway for RAB7A Gene
12 Reactome pathways for RAB7A Gene
7 KEGG pathways for RAB7A Gene
6 GeneGo (Thomson Reuters) pathways for RAB7A Gene
- Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF)
- Delta508-CFTR traffic / Sorting endosome formation in CF
- Normal wtCFTR traffic / Sorting endosome formation
- Transport Clathrin-coated vesicle cycle
- wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
2 Qiagen pathways for RAB7A Gene
Interacting Proteins for RAB7A Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000045 | autophagosome assembly | IMP | 19956673 |
GO:0006622 | protein targeting to lysosome | IMP | 22115783 |
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006810 | transport | IEA | -- |
GO:0006897 | endocytosis | TAS | 2115402 |
No data available for SIGNOR curated interactions for RAB7A Gene
Drugs & Compounds for RAB7A Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Guanosine diphosphate | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Transcripts for RAB7A Gene
mRNA/cDNA for RAB7A Gene
- (1) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (1200) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RAB7A Gene
CRISPR Products
-
OriGene CRISPR knockouts for RAB7A
- genomics-online: gRNA clones - Search results for available RAB7A gene related products
- Applied Biological Materials CRISPR for RAB7A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RAB7A
- GenScript: Design CRISPR guide RNA sequences for RAB7A
miRNA Products
- Search ViGene Biosciences for RAB7A
Inhibitory RNA Products
- Origene shrna, RNAi, and sirna products in human, mouse, rat for RAB7A
- Browse OriGene Inhibitory RNA Products For RAB7A
- genomics-online: shRNA clones - Search results for available RAB7A gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RAB7A gene
Clone Products
- Sino Biological Human cDNA Clone for RAB7A
- Sino Biological Human cDNA Clone for RAB7A
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for RAB7A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RAB7A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RAB7A
- genomics-online: cdna clones - Search results for available RAB7A gene related products
- orf clones - Search results for available RAB7A gene related products
- Applied Biological Materials Clones for RAB7A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for RAB7A Gene
mRNA differential expression in normal tissues according to GTEx for RAB7A Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB7A Gene
NURSA nuclear receptor signaling pathways regulating expression of RAB7A Gene:
RAB7ASOURCE GeneReport for Unigene cluster for RAB7A Gene:
Hs.744853mRNA Expression by UniProt/SwissProt for RAB7A Gene:
P51149-RAB7A_HUMANEvidence on tissue expression from TISSUES for RAB7A Gene
- Nervous system(5)
- Lung(4.9)
- Liver(4.6)
- Skin(4.6)
- Kidney(4.4)
- Intestine(4)
- Blood(3.7)
- Pancreas(3.4)
- Heart(3.3)
- Eye(3.2)
- Muscle(3.1)
- Spleen(2.8)
- Lymph node(2.2)
- Adrenal gland(2.1)
- Bone marrow(2.1)
- Stomach(2.1)
- Thyroid gland(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB7A Gene
- ectoderm
- mesoderm
- cardiovascular
- immune
- integumentary
- lymphatic
- nervous
- skeletal muscle
- skeleton
- brain
- cerebellum
- cranial nerve
- head
- arm
- digit
- foot
- forearm
- hand
- lower limb
- nail
- shin
- thigh
- toe
- upper limb
- blood vessel
- bone marrow
- peripheral nerve
- peripheral nervous system
- skin
- spinal cord
Primer Products
-
OriGene qPCR primer pairs and template standards for RAB7A
-
OriGene qPCR primer pairs for RAB7A
- genomics-online: primer clones - Search results for available RAB7A gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein differential expression in normal tissues for RAB7A Gene
Orthologs for RAB7A Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
oppossum (Monodelphis domestica) |
Mammalia | RAB7A 34 |
|
OneToOne | |
chimpanzee (Pan troglodytes) |
Mammalia | RAB7A 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | RAB7A 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Rab7a 33 |
|
||
mouse (Mus musculus) |
Mammalia | Rab7 33 16 34 |
|
||
cow (Bos Taurus) |
Mammalia | RAB7A 33 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | RAB7A 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | RAB7A 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | RAB7A 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | rab7a 33 |
|
||
Str.4511 33 |
|
||||
zebrafish (Danio rerio) |
Actinopterygii | rab7 33 34 |
|
||
zgc64058 33 |
|
||||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3471 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Rab7 34 |
|
OneToOne | |
worm (Caenorhabditis elegans) |
Secernentea | rab-7 34 |
|
OneToOne | |
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ACR003C 33 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | YPT7 33 34 36 |
|
||
K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D01265g 33 |
|
||
thale cress (Arabidopsis thaliana) |
eudicotyledons | RAB7B 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os05g0516600 33 |
|
||
Os.11710 33 |
|
||||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.7257 34 |
|
OneToOne | |
bread mold (Neurospora crassa) |
Ascomycetes | NCU03711 33 |
|
||
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | ypt7 33 |
|
||
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.5944 33 |
|
- Species where no ortholog for RAB7A was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for RAB7A Gene
(100) SIMAP similar genes for RAB7A Gene using alignment to 7 proteins:
- RAB6A
- RAB23
- RAB11A
- RAB3A
- RAB31
- RAB38
- RAB11B
- RAB7L1
- RAB5C
- RAB41
- RAB43
- RAB28
- RAB5B
- RAB2B
- RAB7B
- RAB44
- RAB25
- RAB6B
- RAB2A
- RAB6A
- RAB15
- RAB34
- RAB9B
- DKFZp686J07132
- RAB35
- RAB39B
- RAB36
- RAB9A
- RAB27A
- RAB27B
- RAB10
- RANP1
- RAB22A
- RAB18
- DKFZp313C1541
- RAB30
- RAB8A
- RAB3C
- MRAS
- TC4
- RAB32
- RAB21
- RAB14
- RAB4A
- RAB19
- RAN
- RAC2
- RABL2B
- RABL2A
- RAB3B
- RAB8B
- RAB4B
- RAP2B
- RAP1B
- RAB3D
- DKFZp547A0616
- RAB5A
- RAB24
- RAB12
- RAP2A
- RASEF
- RAB39A
- LOC51277
- CDC42
- RAB13
- RALA
- RALB
- RAP1A
- RRAS2
- RAB37
- RAB1C
- RHOH
- NRAS
- DKFZp686J06205
- RAB17
- RAB1A
- RAP2C
- c-bas/has
- RHOF
- RAB1B
- RHOD
- RAB26
- RAB6C
- KRAS
- HRAS
- RAB33B
- RHOA
- RND2
- RHOC
- RAB40C
- IFT27
- RRAS
- DIRAS1
- RHEBL1
- RIT2
- ARHE
- RHOJ
- RAB33A
- RAB40B
- RAB40A
Pseudogenes.org Pseudogenes for RAB7A Gene
Variants for RAB7A Gene
SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1005830626 | uncertain-significance, Charcot-Marie-Tooth, Type 2 | 128,726,350(+) | A/G | 5_prime_UTR_variant | |
rs112000804 | benign, likely-benign, not specified, Charcot-Marie-Tooth, Type 2 | 128,726,339(+) | G/T | 5_prime_UTR_variant | |
rs11549750 | likely-benign, Charcot-Marie-Tooth, Type 2 | 128,813,611(+) | A/G | 3_prime_UTR_variant | |
rs11549756 | uncertain-significance, Charcot-Marie-Tooth, Type 2 | 128,806,468(+) | C/G/T | coding_sequence_variant, missense_variant | |
rs121909078 | pathogenic, not-provided, Charcot-Marie-Tooth disease, axonal, type 2b, not provided, Charcot-Marie-Tooth disease 2B (CMT2B) [MIM:600882] | 128,806,576(+) | C/T | coding_sequence_variant, missense_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2676268 | CNV | deletion | 23128226 |
esv3562524 | CNV | deletion | 23714750 |
esv3597725 | CNV | loss | 21293372 |
nsv1127991 | CNV | deletion | 24896259 |
nsv437853 | CNV | loss | 16327808 |
nsv979876 | CNV | duplication | 23825009 |
Additional Variant Information for RAB7A Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB7A Gene
Disorders for RAB7A Gene

(11) MalaCards diseases for RAB7A Gene - From: HGMD, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
charcot-marie-tooth disease, axonal, type 2b |
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vici syndrome |
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charcot-marie-tooth disease |
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choroideremia |
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yunis-varon syndrome |
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UniProtKB/Swiss-Prot
RAB7A_HUMAN- Charcot-Marie-Tooth disease 2B (CMT2B) [MIM:600882]: A dominant axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. {ECO:0000269 PubMed:12545426, ECO:0000269 PubMed:15455439, ECO:0000269 PubMed:17060578, ECO:0000269 PubMed:20028791, ECO:0000269 PubMed:21151572}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for RAB7A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for RAB7A Gene
Publications for RAB7A Gene
- Cloning and mapping of human Rab7 and Rab9 cDNA sequences and identification of a Rab9 pseudogene. (PMID: 9126495) Davies JP … Ioannou YA (Genomics 1997) 2 3 4 22 58
- Genes for hereditary sensory and autonomic neuropathies: a genotype-phenotype correlation. (PMID: 19651702) Rotthier A … Timmerman V (Brain : a journal of neurology 2009) 3 22 44 58
- A novel RAB7 mutation associated with ulcero-mutilating neuropathy. (PMID: 15455439) Houlden H … Ginsberg L (Annals of neurology 2004) 3 4 22 58
- Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy. (PMID: 12545426) Verhoeven K … Timmerman V (American journal of human genetics 2003) 3 4 22 58
- Human VPS34 and p150 are Rab7 interacting partners. (PMID: 14617358) Stein MP … Wandinger-Ness A (Traffic (Copenhagen, Denmark) 2003) 3 4 22 58
Products for RAB7A Gene
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- Invitrogen Antibodies for RAB7A
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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- VectorBuilder custom plasmid, inducible vectors for RAB7A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RAB7A
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RAB7A
- antibodies-online: Search results for 34 available RAB7 Antibodies ranked by validation data
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- 12 IF (p) Antibodies (anti-rat)
- 5 WB Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 12 IF (p) Antibodies (anti-mouse)
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- 20 WB Antibodies (anti-human)
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- 1 IHC Antibody (anti-human)
- 12 IF (p) Antibodies (anti-rat)
- 5 WB Antibodies (anti-rat)
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- Santa Cruz Biotechnology (SCBT) Antibodies for RAB7A
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Sources for RAB7A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
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- (114) diseasecard
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- (120) Genetics Home Reference
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- (125) NCBI Bookshelf
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- (139) VectorBuilder
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- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew