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RAB7A Gene

protein-coding GIFtS: 56

GC03P129928

RAB7A, member RAS oncogene family
(Previous names: RAB7, member RAS oncogene family )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: RAB7)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ20819 ^²
PRO2706 ^²
RAB7 ^², ³

Descriptions
RAB7, member RAS oncogene family ^¹, ²
RAB7A, member RAS oncogene family ^²
Ras-associated protein RAB7 ^²

External Ids
HGNC: 9788¹
Entrez Gene: 7879²
UniProtKB: P51149³
Ensembl: ENSG00000075785⁷

Search outside databases for aliases for RAB7A gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for RAB7A:

RAB family members are small, RAS-related GTP-binding proteins that are important regulators of

vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic

pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late

endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the

cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved

amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2

neuropathies. [provided by RefSeq]

UniProtKB/Swiss-Prot: RAB7A_HUMAN, P51149

Function: Involved in late endocytic transport. Contributes to the maturation of phagosomes

(acidification)

Gene Wiki entry for RAB7A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.3 Ensembl cytogenetic band: 3q21.3 HGNC cytogenetic band: 3q21

RAB7A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P129928: (about GC identifiers)

Start:	129,927,669 bp from pter
End:	130,016,331 bp from pter
Size:	88,663 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_005612.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: RAB7A_HUMAN, P51149 (See protein sequence)

Recommended Name: Ras-related protein Rab-7a

Size: 207 amino acids; 23490 Da

Subunit: Interacts with RILP

Subcellular location: Late endosome. Lysosome. Cytoplasmic vesicle, phagosome. Melanosome.

Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

Sequence caution: Sequence=BAA91390.1; Type=Erroneous translation; Note=Wrong choice of frame;

Sequence=BAF83410.1; Type=Erroneous translation; Note=Wrong choice of frame; Sequence=EAW79303.1;

Type=Erroneous gene model prediction;

PDB structure from and Proteopedia :

1T91 (3D)

1YHN (3D)

Secondary accessions: A8K3V6 Q9NWJ0 Q9UPB0

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004628.4

ENSEMBL proteins:

ENSP00000265062

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (RAB7)
	Human Recombinant Proteins from Abnova (RAB7A)

OriGene Purified Recombinant Human Protein: RAB7A

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	18029348
GO:0005764	lysosome	IDA	15078902
GO:0005770	late endosome	IDA	15078902
GO:0005794	Golgi apparatus	IEA	--
GO:0031410	cytoplasmic vesicle	IEA	--

About this table

Antibodies for RAB7A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for RAB7A
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for RAB7A (Rab7)
	Antibodies from Abcam (RAB7), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (RAB7A)
	Search Novus for antibodies for RAB7A

Assays for RAB7A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P51149

ProtoNet protein and cluster: P51149

1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature

UniProtKB/Swiss-Prot: RAB7A_HUMAN, P51149

Similarity: Belongs to the small GTPase superfamily. Rab family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RAB7A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RAB7A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004637

Applied Biosystems Silencer® siRNAs for RAB7A

Sigma-Aldrich siRNA for RAB7A

Sigma-Aldrich shRNA for RAB7A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004637
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004637
untagged cDNA clone in CMV expression vector: NM_004637

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004637

UniProtKB/Swiss-Prot: RAB7A_HUMAN, P51149

Function: Involved in late endocytic transport. Contributes to the maturation of phagosomes

(acidification)

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003924	GTPase activity	TAS	8954989
GO:0005515	protein binding	IPI	17353931
GO:0005525	GTP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for RAB7A (Your Favorite Gene powered by Ingenuity)

Clathrin-mediated Endocytosis
IL-12 Signaling and Production in Macrophages

GeneDecks RAB7A for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for RAB7A

5/6 Interacting proteins for RAB7A (P51149^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 6 )
Interactant Interaction Details
GeneCard External ID(s)
EIF1B O60739¹ EBI-1056089, EBI-1043343
VHL P40337¹ EBI-1056089, EBI-301246
HGS O14964² MINT-3369790
RAB11A P62491² MINT-3369790
RAB14 P61106² MINT-3369790
About this table
3 Gene Ontology (GO) biological process terms (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis TAS 2115402
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RAB7A
10/11 Novoseek chemical compound relationships for RAB7A gene (see all 11 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
phosphatidylinositol 3-phosphate	70.65	2	14617358 (1)
mannose 6-phosphate	69.12	7	10821869 (2), 18485117 (1), 11152512 (1), 11404461 (1) (see all 6)
geranylgeranyl pyrophosphate	57.77	7	11141079 (5)
gtp	53.04	9	9563513 (2), 14701929 (1), 18272684 (1)
gdp	47.36	3	9563513 (2)
asparagine	27.41	1	15455439 (1)
phosphoinositide	20.25	1	12803922 (1)
lipid	15.90	2	12803922 (1), 11889035 (1)
phosphatidylinositol	8.42	4	14617358 (2), 17651088 (1)
cholesterol	0.00	9	11889035 (4), 11032830 (2), 12803922 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RAB7A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RAB7A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004637

Sigma-Aldrich siRNA for RAB7A

Sigma-Aldrich shRNA for RAB7A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004637

REFSEQ mRNAs for RAB7A gene:

NM_004637.5

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004637

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004637
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004637
                                 untagged cDNA clone in CMV expression vector: NM_004637

Additional cDNA sequence:

AF498942.1 AK024417.1 AK026136.1 AK094449.1 AK225177.1 AK225691.1 AK290721.1 AK298344.1

AK308934.1 AL162009.1 BC008721.2 BC013728.1 BX537775.1 U44104.1

24/42 DOTS entries (see all 42 ):

DT.95217730 DT.100033891 DT.450445 DT.100047749 DT.100660146 DT.100812865 DT.100660135 DT.95283342

DT.120865480 DT.100720266 DT.120865448 DT.120865455 DT.97867830 DT.100059636 DT.120865494 DT.65286440

DT.92467567 DT.95283341 DT.100059638 DT.100660134 DT.100660144 DT.100720250 DT.120865433 DT.120865497

24/1200 AceView cDNA sequences (see all 1200 ):

H56353 AA481485 BU859221 BQ898209 CA448906 BM667525 BQ214089 N24271

AA476599 AU123329 BQ651612 AA548548 AA831272 BQ642364 BE794040 BQ668352

NM_004637 BQ898485 AA161468 AA805527 BM989722 AA488129 R70099 BC008721

highest scoring ESTs for RAB7A:

AA081101 AA088213 AA121263 AA121474 AA157917 AA158844 AA160980 AA160981 AA161468 AA290687

Unigene Cluster for RAB7A:

RAB7A, member RAS oncogene family

Hs.716392 [show with all ESTs]

Unigene Representative Sequence: NM_004637

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000265062

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RAB7A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RAB7A

¹ / ² / ³

6 probe-sets matching RAB7A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
45003_r_at*²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AA630597	0.20	1.00	0.72	1
211960_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BG261416	0.60	1.00	0.82	1
211961_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AK000826	0.60	0.83	0.73	1
211960_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211961_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1570061_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTAATATATG

SOURCE GeneReport for Unigene cluster: Hs.716392
UniProtKB/Swiss-Prot: RAB7A_HUMAN, P51149
Tissue specificity: Widely expressed; high expression found in skeletal muscle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RAB7A gene from 5/27 species (see all 27 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RAB7A¹	--	RAB7A, member RAS oncogene family	95.01(n) 99.52(a)	404007 NM_001003316.1 NP_001003316.1
chimpanzee (Pan troglodytes)	RAB7A¹	--	RAB7A, member RAS oncogene family	99.82(n) 100(a)	470919 XM_526302.2 XP_526302.2
cow (Bos taurus)	RAB7A¹	--	RAB7A, member RAS oncogene family	89.05(n) 98.07(a)	509970 NM_001035081.1 NP_001030253.1
rat (Rattus norvegicus)	Rab7a¹	--	RAB7A, member RAS oncogene family	91.95(n) 99.52(a)	29448 NM_023950.3 NP_076440.1
mouse (Mus musculus)	Rab7^{1, 5}	6 (38.50 cM)⁵	RAB7, member RAS oncogene family^{1, 5}	91.14(n)¹ 99.52(a)¹	19349¹ NM_009005.1¹ NP_033031.1¹ AB232599⁵ AI324642⁵ (see all 34)

About this table Species with no ortholog for RAB7A

ENSEMBL Gene Tree for RAB7A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for RAB7A gene

RAB23² RAB9A² RAB9B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/452 NCBI SNPs in RAB7A are shown (see all 452 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 73)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3772157^1,2	A,C,F,H	130016680(-)	`ACACAT/CGACTA`	1	--	ng3¹		13		EA NS NA EU WA	2138
	rs16851333^1,2	C,F,H	130015161(+)	`CTGACG/ATAATC`	1	--	ut3¹ ese³		11		NA EU EA WA	976
	rs9289333^1,2	C,F,H	129926288(+)	`GAGTGG/ACCAAG`	1	--	ng5¹		4		EU EA WA	420
--	rs4579030^1,2	C	129925925(+)	`catagG/Tgaaaa`	1	--	ng5¹		0	--	--	--	--
--	rs11549759^1,2	H	129999516(+)	`ATAAGA/GAATTC`	1	K/E	mis¹		4		EU EA WA	406
	rs3755593^1,2	H	130015952(-)	`GGGGGA/GAAAAA`	1	--	ut3¹ trp³		5		EA EU WA	1122
	rs4548^1,2	C,F,H	130007943(+)	`TCTCTC/TGGTGT`	1	L/L	syn¹ ese³		8		NA EU EA WA	630
	rs9853945^1,2	A,C,F,H	130011320(+)	`CCCTGA/GATAGA`	1	--	int¹		4		EU EA WA	418
	rs7631994^1,2	A,C,F,H	129964140(+)	`ACTGGT/GCAGAC`	1	--	int¹		8		EU EA WA NA	602
	rs6439144^1,2	A,C,F,H	129936082(+)	`TGCCCA/GTAGCT`	1	--	int¹		4		EU EA WA	418

About this table

HapMap Linkage Disequilibrium images for RAB7A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602298

UniProtKB/Swiss-Prot: RAB7A_HUMAN, P51149

Defects in RAB7A are the cause of Charcot-Marie-Tooth disease type 2B (CMT2B)

[MIM:600882]; also known as hereditary motor and sensory neuropathy II (HMSN2). CMT2B is a form of

Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system.

Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic

properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary

peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of

axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve

conduction velocities, and progressive distal muscle weakness and atrophy. CMT2B is clinically

characterized by marked distal muscle weakness and a high frequency of foot ulcers, infections and

amputations of the toes. CMT2B inheritance is autosomal dominant

1 Novoseek disease relationship for RAB7A gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
charcot-marie-tooth disease	68.25	3	17060578 (1), 15455439 (1), 12545426 (1)

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GeneTests: RAB7A

Charcot-Marie-Tooth Neuropathy Type 2

Human Gene Mutation Database: RAB7A

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/104 PubMed articles for RAB7A gene (see all 104 ):

Cloning and mapping of human Rab7 and Rab9 cDNA sequences and identification of a Rab9 pseudogene. (PubMed id 9126495)^{1, 2, 3, 4} Davies J.P.... Ioannou Y.A. (1997)
Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes. (PubMed id 11179213)^{1, 3, 4} Cantalupo G.... Bucci C. (2001)
A novel RAB7 mutation associated with ulcero-mutilating neuropathy. (PubMed id 15455439)^{1, 3, 4} Houlden H....Ginsberg L. (2004)
Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy. (PubMed id 12545426)^{1, 3, 4} Verhoeven K.... Timmerman V. (2003)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{3, 4} Chi A....Hunt D.F. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
Structural basis for recruitment of RILP by small GTPase Rab7. (PubMed id 15933719)^{3, 4} Wu M.... Song H. (2005)
A unique region of RILP distinguishes it from its related proteins in its regulation of lysosomal morphology and interaction with Rab7 and Rab34. (PubMed id 14668488)^{3, 4} Wang T.... Hong W. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7879	HGNC: 9788	AceView: RAB7	Ensembl:ENSG00000075785	euGenes: HUgn7879
ECgene: RAB7A	H-InvDB: RAB7A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Inherited peripheral neuropathies mutation db	http://www.molgen.ua.ac.be/CMTMutations/
GeneReviews	http://www.genetests.org/query?gene=RAB7A

Licensable Technologies for RAB7A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for RAB7A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RAB7A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RAB7A		Antibodies for RAB7A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for RAB7A		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (RAB7A)
	Antibodies (RAB7A)
	Chimera RNAi (RAB7A)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for RAB7A (Rab7)

	Recombinant Proteins (RAB7)
	Antibodies (RAB7)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for RAB7A

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for RAB7A

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RAB7A Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for RAB7A

Summaries
for RAB7A

Genomic Location
for RAB7A

Proteins
for RAB7A

Protein Domains/
Families
for RAB7A

Gene Function
for RAB7A

Pathways & Interactions
for RAB7A

Drugs & Compounds
for RAB7A

Transcripts
for RAB7A

Expression
for RAB7A

Orthologs
for RAB7A

Paralogs
for RAB7A

SNPs/Variants
for RAB7A

Disorders & Mutations
for RAB7A

Medical News
for RAB7A

Publications
for RAB7A

Search for RAB7A

Genome Databases showing RAB7A

Other Databases showing RAB7A

Specialized Databases showing RAB7A

Licensable Technologies
for RAB7A

Services
for RAB7A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RAB7A Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor RAB7A

Summariesfor RAB7A

Genomic Locationfor RAB7A

Proteinsfor RAB7A

Protein Domains/Familiesfor RAB7A

Gene Functionfor RAB7A

Pathways & Interactionsfor RAB7A

Drugs & Compoundsfor RAB7A

Transcriptsfor RAB7A

Expression for RAB7A

Orthologsfor RAB7A

Paralogsfor RAB7A

SNPs/Variantsfor RAB7A

Disorders & Mutationsfor RAB7A

Medical Newsfor RAB7A

Publicationsfor RAB7A

Search for RAB7A

Genome Databases showing RAB7A

Other Databases showing RAB7A

Specialized Databases showing RAB7A

Licensable Technologiesfor RAB7A

Servicesfor RAB7A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RAB7A

Summaries
for RAB7A

Genomic Location
for RAB7A

Proteins
for RAB7A

Protein Domains/
Families
for RAB7A

Gene Function
for RAB7A

Pathways & Interactions
for RAB7A

Drugs & Compounds
for RAB7A

Transcripts
for RAB7A

Expression
for RAB7A

Orthologs
for RAB7A

Paralogs
for RAB7A

SNPs/Variants
for RAB7A

Disorders & Mutations
for RAB7A

Medical News
for RAB7A

Publications
for RAB7A

Licensable Technologies
for RAB7A

Services
for RAB7A