RAB6C Gene
protein-coding GIFtS: 48
GCID: GC02P130737
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RAB6C, member RAS oncogene family
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Aliases
for RAB6C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RAB6C, Member RAS Oncogene Family1 2 | | WTH31 2 3 5 | | Rab6-Like Protein WTH32 3 | | Ras-Related Protein Rab-6C2 |
Export aliases for RAB6C gene to outside databasesPrevious GC identifers: GC02P128038 GC02M130298 GC02P130643 GC02M132331 GC02P130831 GC02M131954 GC02P130454 GC02U900801 GC11M073065 GC02P123046 |
Summaries
for RAB6C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RAB6C_HUMAN, Q9H0N0Function: May be involved in the regulation of centrosome duplication and cell cycle progression
Gene Wiki entry for RAB6C
|
Genomic Views
for RAB6C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAB6C gene promoter:
Nkx3-1 LUN-1 AP-4 Nkx2-5 Nkx3-1 v2 Nkx6-1 FOXO4 Nkx3-1 v3 IRF-7A
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAB6C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB6C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q21.1 Ensembl cytogenetic band: 2q21.1 HGNC cytogenetic band: 2q21.1RAB6C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P130737: view genomic region
(about GC identifiers)
Start:
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130,737,235 bp from pter |
End:
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130,740,311 bp from pter |
Size:
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3,077 bases |
Orientation:
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plus strand |
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Proteins
for RAB6C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RAB6C_HUMAN, Q9H0N0 (See
protein sequence)Recommended Name: Ras-related protein Rab-6C Size: 254 amino acids; 28355 Da
Subcellular location: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, centrosome
Miscellaneous: Primate-specific retrogene derived from isoform 2 of RAB6A transcript
Miscellaneous: Previously reported to exhibit GTP-binding affinity comparable to that of RAB6A (PubMed:16103095). Incontrast (PubMed:20064528) concludes that RAB6C is an inefficient GTP-binding
Secondary accessions: Q53RU3 Q6FIF7 Q9P128Explore the universe of human proteins at neXtProt for RAB6C: NX_Q9H0N0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H0N0
RAB6C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115520.2
ENSEMBL proteins: ENSP00000387307
Human Recombinant Protein Products for RAB6C:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
RAB6C for ontologies About GeneDecksing
RAB6C Antibody Products:
Assay Products for RAB6C: |
Protein
Domains /
Families
for RAB6C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAB6C for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H0N0ProtoNet protein and cluster: Q9H0N0 1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: RAB6C_HUMAN, Q9H0N0Similarity: Belongs to the small GTPase superfamily. Rab family |
Function
for RAB6C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: RAB6C_HUMAN, Q9H0N0Function: May be involved in the regulation of centrosome duplication and cell cycle progression Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
RAB6C for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB6C
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB6C
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RAB6C (NM_032144) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAB6C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB6C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB6C |
|
Pathways & Interactions
for RAB6C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Sertoli-Sertoli Cell Junction Dynamics | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB6C
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB6C
1 Interacting protein for RAB6C (Q9H0N02) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
RAB6C for ontologies About GeneDecksing
|
Drugs & Compounds
for RAB6C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RAB6C
Search CenterWatch for drugs/clinical trials and news about RAB6C
|
Transcripts
for RAB6C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RAB6C gene: NM_032144.2 Unigene Cluster for RAB6C: RAB6C, member RAS oncogene family Hs.591552 [show with all ESTs]Unigene Representative Sequence: AL1367271 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000410061(uc002tpx.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB6C
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB6C
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RAB6C (NM_032144) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAB6C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB6C |
Additional cDNA sequence: AF309646.1 AK055504.1 AL136727.1 BC120998.2 BC120999.1 CR533469.1 3 DOTS entries: DT.100823625 DT.120744711 DT.405519
GeneLoc Exon Structure
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Expression
for RAB6C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RAB6C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RAB6C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAB6C
SOURCE GeneReport for Unigene cluster: Hs.591552
UniProtKB/Swiss-Prot: RAB6C_HUMAN, Q9H0N0Tissue specificity: Highest levels are found in fetal and adult brain, prostate, testis and spinal cord. Undetectableexpression in adrenal gland, skeletal muscle, bone marrow, fetal, and adult liver, heart, salivary gland, and trachea.Detected in the HEK293, HEK293T, LNCaP, MCF-7, T-47D and EVSA-T cell lines (at protein level)
SABiosciences Custom PCR Arrays for RAB6C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB6C
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat RAB6C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB6C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB6C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB6C |
Orthologs
for RAB6C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RAB6C gene from 6/21 species (see all 21) About this table
ENSEMBL Gene Tree for RAB6C (if available)
TreeFam Gene Tree for RAB6C (if available) |
Paralogs
for RAB6C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RAB6C gene
- WTH3DI RAB6A2 RAB412 RAB282 RAB6B2
18/77 SIMAP similar genes for RAB6C using alignment to 2 protein entries: RAB6C_HUMAN (see all proteins)
(see all similar genes):RAB6A RAB6B RAB6A' RAB41 RAB39B RAB11B
RAB22A RAB3C RAB8B RAB5C RAB11A RAB2A
RAB10 RAB31 RAB17 DKFZp686J06205 RAB27B RAB35
RAB6C for paralogs About GeneDecksing
|
Genomic Variants
for RAB6C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RAB6C (130737235 - 130740311 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for RAB6C
9 CNVs: 89962 78758 0269 0024 3393 32360 68165 89963 8387 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB6C |
|
Disorders
/ Diseases
for RAB6C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RAB6C for disorders About GeneDecksing
OMIM gene information: 612909
OMIM disorders: --
3  diseases for RAB6C: About MalaCardsbreast cancer malaria prostatitis
Human Genome Epidemiology (HuGE) Navigator: RAB6C (3 documents)
Export disorders for RAB6C gene to outside databases
|
Publications
for RAB6C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RAB6C gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with RAB6C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- WTH3 is a direct target of the p53 protein. (PubMed id 17426708)1, 2, 3 Tian K....Xu H. (2007)
- Rab6c, a new member of the Rab gene family, is involved in drug resistance in MCF7/AdrR cells. (PubMed id 11054569)1, 2, 3 Shan J.... Xu H.-P. (2000)
- WTH3, a new member of the Rab6 gene family, and multidrug resistance. (PubMed id 12007787)1, 2, 9 Shan J.... Xu H.-P. (2002)
- RAB6C is a retrogene that encodes a centrosomal prote in involved in cell cycle progression. (PubMed id 20064528)1, 2 Young J....Goud B. (2010)
- Methylation of WTH3, a possible drug resistant gene, inhibits p53 regulated expression. (PubMed id 18992151)1, 2 Tian K....Xu H. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Epigenetic regulation of WTH3 in primary and cultured drug-resistant breast cancer cells. (PubMed id 16267028)1, 9 Tian K....Xu H. (2005)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Crystallization and preliminary X-ray crystallographic studies of Rab6A'(Q72L): a GTP-locked form. (PubMed id 22949199)1 Shin Y.C....Park H.H. (2012)
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External Searches for RAB6C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing RAB6C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RAB6C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB6C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RAB6C gene:
Search GeneIP for patents involving RAB6C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RAB6C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAB6C | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB6C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB6C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB6C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB6C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB6C |
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 | | | RAB6C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB6C |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB6C |
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