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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB6C Gene

protein-coding   GIFtS: 48
GCID: GC02P130737

RAB6C, Member RAS Oncogene Family

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAB6C, Member RAS Oncogene Family1 2
WTH32 3 5
Rab6-Like Protein WTH32 3
Ras-Related Protein Rab-6C2

External Ids:    HGNC: 165251   Entrez Gene: 840842   Ensembl: ENSG000002220147   OMIM: 6129095   UniProtKB: Q9H0N03   

Export aliases for RAB6C gene to outside databases

Previous GC identifers: GC02P128038 GC02M130298 GC02P130643 GC02M132331 GC02P130831 GC02M131954 GC02P130454 GC02U900801 GC11M073065 GC02P123046


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RAB6C Gene: 
RAB6C (RAB6C, member RAS oncogene family) is a protein-coding gene. Diseases associated with RAB6C include breast cancer, and prostatitis, and among its related super-pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB6A.

UniProtKB/Swiss-Prot: RAB6C_HUMAN, Q9H0N0
Function: May be involved in the regulation of centrosome duplication and cell cycle progression

Gene Wiki entry for RAB6C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB6C gene promoter:
         Nkx3-1   LUN-1   AP-4   Nkx2-5   Nkx3-1 v2   Nkx6-1   FOXO4   Nkx3-1 v3   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB6C promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB6C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB6C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.1   Ensembl cytogenetic band:  2q21.1   HGNC cytogenetic band: 2q21.1

RAB6C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB6C gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P130737:  view genomic region     (about GC identifiers)

Start:
130,737,235 bp from pter      End:
130,740,311 bp from pter
Size:
3,077 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RAB6C_HUMAN, Q9H0N0 (See protein sequence)
Recommended Name: Ras-related protein Rab-6C  
Size: 254 amino acids; 28355 Da
Subcellular location: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Miscellaneous: Primate-specific retrogene derived from isoform 2 of RAB6A transcript
Miscellaneous: Previously reported to exhibit GTP-binding affinity comparable to that of RAB6A (PubMed:16103095).
In contrast (PubMed:20064528) concludes that RAB6C is an inefficient GTP-binding
Secondary accessions: Q53RU3 Q6FIF7 Q9P128

Explore the universe of human proteins at neXtProt for RAB6C: NX_Q9H0N0

Explore proteomics data for RAB6C at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H0N0

  • RAB6C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAB6C Protein Expression
    REFSEQ proteins: NP_115520.2  
    ENSEMBL proteins: 
     ENSP00000387307  

    Human Recombinant Protein Products for RAB6C: 
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    Cloud-Clone Corp. Proteins for RAB6C 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IC10455022
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome IDA--
    GO:0016020membrane ----

    RAB6C for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9H0N0

    ProtoNet protein and cluster: Q9H0N0

    1 Blocks protein domain: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RAB6C_HUMAN, Q9H0N0
    Similarity: Belongs to the small GTPase superfamily. Rab family


    RAB6C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAB6C_HUMAN, Q9H0N0
    Function: May be involved in the regulation of centrosome duplication and cell cycle progression

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA10455022
    GO:0005525GTP binding IEA--
         
    RAB6C for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAB6C About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB6C
        Epithelial Tight Junctions



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB6C

    1 Interacting protein for RAB6C (Q9H0N02) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --Q8CHW52MINT-7899000
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process IDA10455022
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS10455022

    RAB6C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAB6C

    Search CenterWatch for drugs/clinical trials and news about RAB6C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAB6C gene: 
    NM_032144.2  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000410061(uc002tpx.1)
    miRNA
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB6C
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB6C

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB6C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RAB6C Expression
    About this image


    See RAB6C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAB6C

    UniProtKB/Swiss-Prot: RAB6C_HUMAN, Q9H0N0
    Tissue specificity: Highest levels are found in fetal and adult brain, prostate, testis and spinal cord.
    Undetectable expression in adrenal gland, skeletal muscle, bone marrow, fetal, and adult liver, heart, salivary
    gland, and trachea. Detected in the HEK293, HEK293T, LNCaP, MCF-7, T-47D and EVSA-T cell lines (at protein level)

        SABiosciences Custom PCR Arrays for RAB6C
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB6C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RAB6C gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves RAB6A6
    Ras-related protein Rab-6A
    92(a)
    possible ortholog
    1(194721970-194780643)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    90(a)
    81(a)
    possible ortholog
    possible ortholog
    GL343983.1(92334-113993)
    AAWZ02038411(231-10643)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005364961 ras-related protein Rab-6A-like 81.54(n)
    89.78(a)
      100536496  XM_003199381.1  XP_003199429.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rab63 RAB small monomeric GTPase 79(a)   33C4   --
    worm
    (Caenorhabditis elegans)
    Secernentea rab-6.26
    rab-6.16
    Ras-related protein Rab-6.1
    74(a)
    70(a)
    many ↔ many
    many ↔ many
    X(17222475-17224577)
    III(9004780-9005957)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YPT66
    Rab family GTPase, Ras-like GTP binding protein in...
    55(a)
    1 → many
    XII(668244-668891)
            Species with no ortholog for RAB6C

    ENSEMBL Gene Tree for RAB6C (if available)
    TreeFam Gene Tree for RAB6C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAB6C gene
    WTH3DI  RAB6A2  RAB412  RAB362  RAB342  RAB6B2  
    18/77 SIMAP similar genes for RAB6C using alignment to 2 protein entries:     RAB6C_HUMAN (see all proteins) (see all similar genes):
    RAB6A    RAB6B    RAB6A'    RAB41    RAB39B    RAB5B
    RAB11B    RAB22A    RAB3C    RAB8B    RAB5C    RAB11A
    RAB2A    RAB10    RAB31    RAB17    DKFZp686J06205    RAB27B

    RAB6C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/18 SNPs in RAB6C are shown (see all 18)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0381614
    ----see VAR_0381612 A T mis40--------
    rs1872633851,2
    --130740058(+) CTTAGC/TCCCCT 1 -- ut310--------
    rs1916847061,2
    --130740144(+) GAATAC/GAGAAA 1 -- ut310--------
    rs1832578201,2
    --130740207(+) GATGGA/TGTTAT 1 -- ut310--------
    rs1504859301,2
    C--130740230(+) TAATAC/TAATAT 1 -- ut310--------
    rs1877242141,2
    --130740277(+) TTGACA/GTGGCA 1 -- ut310--------
    rs1926559571,2
    --130740348(+) GTCATA/GACTTC 1 -- ds50010--------
    rs67215811,2
    C,F,H--130740562(+) AAAAGA/GAAACA 1 -- ds500124Minor allele frequency- G:0.21NS EA NA WA CSA 2350
    rs1856619251,2
    --130740612(+) TTACCA/GCCTTT 1 -- ds50010--------
    rs1895498781,2
    --130740663(+) ACACAA/C/GAACGT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for RAB6C (130737235 - 130740311 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for RAB6C (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv471419CNV Duplication19718026
    nsv10157CNV Loss18304495
    nsv459274CNV Loss19166990
    nsv428403CNV Loss18775914
    nsv821629CNV Loss15273396
    esv29254CNV Loss19812545
    nsv834374CNV Gain17160897
    nsv875045CNV Gain21882294
    nsv875050CNV Gain21882294
    esv2751826CNV Gain17911159

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612909    OMIM disorders: --

    2 diseases for RAB6C:    About MalaCards
    breast cancer    prostatitis


    RAB6C for disorders           About GeneDecksing

    Genetic Association Database (GAD): RAB6C
    Human Genome Epidemiology (HuGE) Navigator: RAB6C (3 documents)

    Export disorders for RAB6C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB6C gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with RAB6C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. WTH3 is a direct target of the p53 protein. (PubMed id 17426708)1, 2, 3 Tian K....Xu H. (2007)
    2. Rab6c, a new member of the Rab gene family, is involved in drug resistance in MCF7/AdrR cells. (PubMed id 11054569)1, 2, 3 Shan J.... Xu H.-P. (2000)
    3. WTH3, a new member of the Rab6 gene family, and multidrug resistance. (PubMed id 12007787)1, 2, 9 Shan J.... Xu H.-P. (2002)
    4. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (2010)
    5. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (2010)
    6. RAB6C is a retrogene that encodes a centrosomal prote in involved in cell cycle progression. (PubMed id 20064528)1, 2 Young J....Goud B. (2010)
    7. Methylation of WTH3, a possible drug resistant gene, inhibits p53 regulated expression. (PubMed id 18992151)1, 2 Tian K....Xu H. (2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    10. Epigenetic regulation of WTH3 in primary and cultured drug-resistant breast cancer cells. (PubMed id 16267028)1, 9 Tian K....Xu H. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84084 HGNC: 16525 Ensembl:ENSG00000222014 euGenes: HUgn84084 ECgene: RAB6C
    H-InvDB: RAB6C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB6C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB6C Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAB6C gene:
    Search GeneIP for patents involving RAB6C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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