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RAB6C Gene

protein-coding GIFtS: 40

GC02P130454

RAB6C, member RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
WTH3 ^¹, ², ³

Descriptions
RAB6C, member RAS oncogene family ^²
Rab6-like protein WTH3 ^³

External Ids
HGNC: 16525¹
Entrez Gene: 84084²
UniProtKB: Q9H0N0³
Ensembl: ENSG00000222014⁷

Search outside databases for aliases for RAB6C gene

Previous GC identifers: GC02P128038 GC02M130298 GC02P130643 GC02M132331 GC02P130831 GC02M131954 GC02U900801 GC11M073065

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for RAB6C

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.1 Ensembl cytogenetic band: 2q21.1 HGNC cytogenetic band: 2q21.1

RAB6C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P130454: (about GC identifiers)

Start:	130,453,705 bp from pter
End:	130,456,781 bp from pter
Size:	3,077 bases
Orientation:	plus strand

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RAB6C_HUMAN, Q9H0N0 (See protein sequence)

Recommended Name: Ras-related protein Rab-6C

Size: 254 amino acids; 28355 Da

Secondary accessions: Q53RU3 Q6FIF7 Q9P128

REFSEQ proteins: NP_115520.2

ENSEMBL proteins:

ENSP00000387307

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (RAB6C)
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: RAB6C

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IC	10455022
GO:0005794	Golgi apparatus	IEA	--

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Antibodies for RAB6C:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (RAB6C), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for RAB6C

Assays for RAB6C:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9H0N0

ProtoNet protein and cluster: Q9H0N0

1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature

UniProtKB/Swiss-Prot: RAB6C_HUMAN, Q9H0N0

Similarity: Belongs to the small GTPase superfamily. Rab family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RAB6C)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032144

Applied Biosystems Silencer® siRNAs for RAB6C

Sigma-Aldrich siRNA for RAB6C

Sigma-Aldrich shRNA for RAB6C

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_032144
Myc/DDK tagged cDNA clone in CMV expression vector: NM_032144
untagged cDNA clone in CMV expression vector: NM_032144

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_032144

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003924	GTPase activity	IDA	10455022
GO:0005515	protein binding	IEA	--
GO:0005525	GTP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for RAB6C

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007264	small GTPase mediated signal transduction	TAS	10455022
GO:0015031	protein transport	IEA	--
GO:0042493	response to drug	IDA	11054569

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Enzo Life Sciences drugs & compounds for RAB6C

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RAB6C

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RAB6C)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032144

Sigma-Aldrich siRNA for RAB6C

Sigma-Aldrich shRNA for RAB6C

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_032144

REFSEQ mRNAs for RAB6C gene:

NM_032144.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_032144

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_032144
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_032144
                                 untagged cDNA clone in CMV expression vector: NM_032144

highest scoring ESTs for RAB6C:

BG701957 R24274 AI907928 AK055504 AL136727 BM920940 AF309646 BC120998 BC120999 DA172795

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000410061

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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RAB6C expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RAB6C

¹ / ² / ³

4 probe-sets matching RAB6C gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
201047_x_at²	U133-A	4	1.00	0.28	--	--	--	--	--	--	--
210406_s_at²^{, 3}	U133-A	4	1.00	0.27	--	--	AL136727	0.40	0.67	0.55	1
201047_x_at²	U133Plus2	4	1.00	0.28	--	--	--	--	--	--	--
210406_s_at²	U133Plus2	4	1.00	0.27	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --
Expression variation in blood from EXPOLDB for RAB6C

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for RAB6C gene from 1 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
fruit fly (Drosophila melanogaster)	Rab6³	33C4	RAB small monomeric GTPase	79(a)	--

About this table Species with no ortholog for RAB6C

ENSEMBL Gene Tree for RAB6C

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for RAB6C gene

LOC150786¹ RAB20² RAB21² RAB41² RAB6A² RAB6B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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8 NCBI SNPs in RAB6C are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs7420156^1,2	A,C	130451915(+)	`aggctC/Ggagtg`	1	--	ng5¹		0	--	--	--	--
--	rs6721581^1,2	C	130457032(+)	`AAAAGA/GAAACA`	1	--	ng3¹		0	--	--	--	--
--	rs3816518^1,2	H	130452408(-)	`ATGCTT/CGGTAC`	1	--	ng5¹		4		EU EA WA	418
--	rs6730222^1,2	A	130452415(+)	`GCATGA/GTCAAA`	1	--	ng5¹		0	--	--	--	--
--	rs28529283^1,2	--	130457249(+)	`GTTGCC/TCAGGC`	1	--	ng3¹		0	--	--	--	--
--	rs72863819^1,2	--	130457179(+)	`AGTTCA/GAATTA`	1	--	ng3¹		0	--	--	--	--
--	rs6742664^1,2	--	130452081(+)	`ggctgC/Gagtgc`	1	--	ng5¹		0	--	--	--	--
--	rs73959968^1,2	--	130452593(+)	`ATCAGC/TATATA`	1	--	ng5¹		0	--	--	--	--

About this table
The following additional 3 SNP(s) have been found in Applied Biosystems data source:

(Click for Applied Biosystems TaqMan ® Genotyping Assay)

rs9807997

rs4662673

rs6716238

HapMap Linkage Disequilibrium images for RAB6C (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/11 PubMed articles for RAB6C gene (see all 11 ):

Rab6c, a new member of the Rab gene family, is involved in drug resistance in MCF7/AdrR cells. (PubMed id 11054569)^{2, 3, 4} Shan J.... Xu H.-P. (2000)
WTH3, a new member of the Rab6 gene family, and multidrug resistance. (PubMed id 12007787)^{1, 3, 4} Shan J.... Xu H.-P. (2002)
WTH3 is a direct target of the p53 protein. (PubMed id 17426708)^{2, 3} Tian K....Xu H. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{3, 4} Wiemann S.... Poustka A. (2001)
Epigenetic regulation of WTH3 in primary and cultured drug-resistant breast cancer cells. (PubMed id 16267028)^{1, 3} Tian K....Xu H. (2005)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)⁴ Hillier L.W....Wilson R.K. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Rab6 is phosphorylated in thrombin-activated platelets by a protein kinase C-dependent mechanism: effects on GTP/GDP binding and cellular distribution. (PubMed id 10455022)³ Fitzgerald M.L. and Reed G.L. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 84084	HGNC: 16525	Ensembl:ENSG00000222014	euGenes: HUgn84084	ECgene: RAB6C
H-InvDB: RAB6C

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for RAB6C	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for RAB6C
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for RAB6C:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RAB6C-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RAB6C		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for RAB6C		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
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	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
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	shRNA in GFP-retroviral vector

Search Tocris compounds for RAB6C

	Drugs for RAB6C
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RAB6C Gene

protein-coding GIFtS: 40

Aliases &
Descriptions
for RAB6C

Summaries
for RAB6C

Genomic Location
for RAB6C

Proteins
for RAB6C

Protein Domains/
Families
for RAB6C

Gene Function
for RAB6C

Pathways & Interactions
for RAB6C

Drugs & Compounds
for RAB6C

Transcripts
for RAB6C

Expression
for RAB6C

Orthologs
for RAB6C

Paralogs
for RAB6C

SNPs/Variants
for RAB6C

Disorders & Mutations
for RAB6C

Medical News
for RAB6C

Publications
for RAB6C

Search for RAB6C

Genome Databases showing RAB6C

Other Databases showing RAB6C

Specialized Databases showing RAB6C

Licensable Technologies
for RAB6C

Services
for RAB6C

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RAB6C Gene

protein-coding GIFtS: 40

Aliases & Descriptionsfor RAB6C

Summariesfor RAB6C

Genomic Locationfor RAB6C

Proteinsfor RAB6C

Protein Domains/Familiesfor RAB6C

Gene Functionfor RAB6C

Pathways & Interactionsfor RAB6C

Drugs & Compoundsfor RAB6C

Transcriptsfor RAB6C

Expression for RAB6C

Orthologsfor RAB6C

Paralogsfor RAB6C

SNPs/Variantsfor RAB6C

Disorders & Mutationsfor RAB6C

Medical Newsfor RAB6C

Publicationsfor RAB6C

Search for RAB6C

Genome Databases showing RAB6C

Other Databases showing RAB6C

Specialized Databases showing RAB6C

Licensable Technologiesfor RAB6C

Servicesfor RAB6C

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RAB6C

Summaries
for RAB6C

Genomic Location
for RAB6C

Proteins
for RAB6C

Protein Domains/
Families
for RAB6C

Gene Function
for RAB6C

Pathways & Interactions
for RAB6C

Drugs & Compounds
for RAB6C

Transcripts
for RAB6C

Expression
for RAB6C

Orthologs
for RAB6C

Paralogs
for RAB6C

SNPs/Variants
for RAB6C

Disorders & Mutations
for RAB6C

Medical News
for RAB6C

Publications
for RAB6C

Licensable Technologies
for RAB6C

Services
for RAB6C