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Aliases for RAB6C Gene

Aliases for RAB6C Gene

  • RAB6C, Member RAS Oncogene Family 2 3 5
  • Rab6-Like Protein WTH3 3 4
  • WTH3 3 4

External Ids for RAB6C Gene

Previous GeneCards Identifiers for RAB6C Gene

  • GC02P128038
  • GC02M130298
  • GC02P130643
  • GC02M132331
  • GC02P130831
  • GC02M131954
  • GC02P130454
  • GC02U900801
  • GC11M073065
  • GC02P130737
  • GC02P123046

Summaries for RAB6C Gene

GeneCards Summary for RAB6C Gene

RAB6C (RAB6C, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB41.

UniProtKB/Swiss-Prot for RAB6C Gene

  • May be involved in the regulation of centrosome duplication and cell cycle progression.

Gene Wiki entry for RAB6C Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB6C Gene

Genomics for RAB6C Gene

Regulatory Elements for RAB6C Gene

Enhancers for RAB6C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RAB6C on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB6C Gene

129,979,662 bp from pter
129,982,738 bp from pter
3,077 bases
Plus strand

Genomic View for RAB6C Gene

Genes around RAB6C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB6C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB6C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB6C Gene

Proteins for RAB6C Gene

  • Protein details for RAB6C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-6C
    Protein Accession:
    Secondary Accessions:
    • Q53RU3
    • Q6FIF7
    • Q9P128

    Protein attributes for RAB6C Gene

    254 amino acids
    Molecular mass:
    28355 Da
    Quaternary structure:
    No Data Available
    • Previously reported to exhibit GTP-binding affinity comparable to that of RAB6A (PubMed:16103095). In contrast (PubMed:20064528) concludes that RAB6C is an inefficient GTP-binding.
    • Primate-specific retrogene derived from isoform 2 of RAB6A transcript.

neXtProt entry for RAB6C Gene

Proteomics data for RAB6C Gene at MOPED

Post-translational modifications for RAB6C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB6C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB6C Gene

Domains & Families for RAB6C Gene

Gene Families for RAB6C Gene

Suggested Antigen Peptide Sequences for RAB6C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB6C: view

Function for RAB6C Gene

Molecular function for RAB6C Gene

UniProtKB/Swiss-Prot Function:
May be involved in the regulation of centrosome duplication and cell cycle progression.
genes like me logo Genes that share phenotypes with RAB6C: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB6C Gene

Localization for RAB6C Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB6C Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

Jensen Localization Image for RAB6C Gene COMPARTMENTS Subcellular localization image for RAB6C gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3
golgi apparatus 3

Gene Ontology (GO) - Cellular Components for RAB6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with RAB6C: view

Pathways & Interactions for RAB6C Gene

genes like me logo Genes that share pathways with RAB6C: view

Pathways by source for RAB6C Gene

1 Qiagen pathway for RAB6C Gene

Interacting Proteins for RAB6C Gene

Gene Ontology (GO) - Biological Process for RAB6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IBA --
GO:0006891 intra-Golgi vesicle-mediated transport IBA --
GO:0006913 nucleocytoplasmic transport IEA --
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IEA,TAS 10455022
genes like me logo Genes that share ontologies with RAB6C: view

No data available for SIGNOR curated interactions for RAB6C Gene

Drugs & Compounds for RAB6C Gene

No Compound Related Data Available

Transcripts for RAB6C Gene

mRNA/cDNA for RAB6C Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RAB6C Gene

No ASD Table

Relevant External Links for RAB6C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB6C Gene

mRNA expression in normal human tissues for RAB6C Gene

Protein differential expression in normal tissues from HIPED for RAB6C Gene

This gene is overexpressed in Bone (19.2), Adipocyte (18.8), and Pancreas (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB6C Gene

mRNA Expression by UniProt/SwissProt for RAB6C Gene

Tissue specificity: Highest levels are found in fetal and adult brain, prostate, testis and spinal cord. Undetectable expression in adrenal gland, skeletal muscle, bone marrow, fetal, and adult liver, heart, salivary gland, and trachea. Detected in the HEK293, HEK293T, LNCaP, MCF-7, T-47D and EVSA-T cell lines (at protein level).
genes like me logo Genes that share expression patterns with RAB6C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for RAB6C Gene

Orthologs for RAB6C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB6C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RAB6C 36
  • 92 (a)
(Canis familiaris)
Mammalia RAB6C 36
  • 91 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 89 (a)
(Mus musculus)
Mammalia Rab6a 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
(Pan troglodytes)
Mammalia RAB6C 36
  • 97 (a)
(Gallus gallus)
Aves RAB6A 36
  • 92 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 85 (a)
-- 36
  • 90 (a)
(Danio rerio)
Actinopterygii CU694807.1 36
  • 88 (a)
rab6a 36
  • 89 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab6 37
  • 79 (a)
Rab6 36
  • 80 (a)
(Caenorhabditis elegans)
Secernentea rab-6.2 36
  • 74 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT6 36
  • 56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10389 36
  • 78 (a)
Species with no ortholog for RAB6C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RAB6C Gene

Gene Tree for RAB6C (if available)
Gene Tree for RAB6C (if available)

Paralogs for RAB6C Gene

Paralogs for RAB6C Gene

genes like me logo Genes that share paralogs with RAB6C: view

Variants for RAB6C Gene

Sequence variations from dbSNP and Humsavar for RAB6C Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_038161 -
rs6721581 -- 129,982,989(+) AAAAG(A/G)AAACA downstream-variant-500B
rs28529283 -- 129,983,206(+) GTTGC(C/T)CAGGC downstream-variant-500B
rs72863819 -- 129,983,136(+) AGTTC(A/G)AATTA downstream-variant-500B
rs77309416 -- 129,983,183(+) TTTTT(A/T)TACGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RAB6C Gene

Variant ID Type Subtype PubMed ID
nsv821629 CNV Loss 15273396
nsv459274 CNV Loss 19166990
nsv875045 CNV Gain 21882294
essv3693 CNV CNV 17122850
dgv1247e1 CNV Complex 17122850
esv2751826 CNV Gain 17911159
nsv875050 CNV Gain 21882294
dgv1248e1 CNV Complex 17122850
dgv1249e1 CNV Complex 17122850
dgv1250e1 CNV Complex 17122850
nsv428403 CNV Loss 18775914
nsv834374 CNV Gain 17160897
nsv10157 CNV Loss 18304495
esv29254 CNV Loss 19812545
nsv483020 CNV Complex 15286789
dgv1251e1 CNV Complex 17122850
nsv471419 CNV Duplication 19718026

Variation tolerance for RAB6C Gene

Residual Variation Intolerance Score: 77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.76; 66.57% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RAB6C Gene

Disorders for RAB6C Gene

Relevant External Links for RAB6C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RAB6C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB6C Gene

Publications for RAB6C Gene

  1. WTH3 is a direct target of the p53 protein. (PMID: 17426708) Tian K. … Xu H. (Br. J. Cancer 2007) 2 3 4 67
  2. Epigenetic regulation of WTH3 in primary and cultured drug-resistant breast cancer cells. (PMID: 16267028) Tian K. … Xu H. (Cancer Res. 2005) 3 23
  3. WTH3, a new member of the Rab6 gene family, and multidrug resistance. (PMID: 12007787) Shan J. … Xu H.-P. (Biochim. Biophys. Acta 2002) 3 23
  4. Rab6c, a new member of the Rab gene family, is involved in drug resistance in MCF7/AdrR cells. (PMID: 11054569) Shan J. … Xu H.-P. (Gene 2000) 2 3
  5. Genome-wide association study of chronic periodontitis in a general German population. (PMID: 24024966) Teumer A. … Kocher T. (J. Clin. Periodontol. 2013) 3

Products for RAB6C Gene

Sources for RAB6C Gene