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Aliases for RAB6B Gene

Aliases for RAB6B Gene

  • RAB6B, Member RAS Oncogene Family 2 3 5

External Ids for RAB6B Gene

Previous GeneCards Identifiers for RAB6B Gene

  • GC03M130506
  • GC03M134292
  • GC03M134828
  • GC03M134868
  • GC03M135025
  • GC03M133543
  • GC03M130921

Summaries for RAB6B Gene

GeneCards Summary for RAB6B Gene

RAB6B (RAB6B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Vesicle-mediated transport. GO annotations related to this gene include GTP binding and myosin V binding. An important paralog of this gene is RAB41.

UniProtKB/Swiss-Prot for RAB6B Gene

  • Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells.

Gene Wiki entry for RAB6B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB6B Gene

Genomics for RAB6B Gene

Regulatory Elements for RAB6B Gene

Promoters for RAB6B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAB6B on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB6B Gene

Chromosome:
3
Start:
133,824,235 bp from pter
End:
133,895,847 bp from pter
Size:
71,613 bases
Orientation:
Minus strand

Genomic View for RAB6B Gene

Genes around RAB6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB6B Gene

Proteins for RAB6B Gene

  • Protein details for RAB6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRW1-RAB6B_HUMAN
    Recommended name:
    Ras-related protein Rab-6B
    Protein Accession:
    Q9NRW1
    Secondary Accessions:
    • B2R5Z9
    • B7Z337
    • D3DND3
    • Q92929

    Protein attributes for RAB6B Gene

    Size:
    208 amino acids
    Molecular mass:
    23462 Da
    Quaternary structure:
    • Interacts with CCDC64/BICDR1; leads to its accumulation in the pericentrosomal region (By similarity). Interacts with RAB6KIFL. Interacts (GTP-bound) with BICD1 (via C-terminus); the interaction is direct. Interacts (GDP-bound) with DYNLRB1. Interacts (GTP-bound) with APBA1/MINT1 isoform 2, also called Mint1_826, but not with isoform 1.

    Three dimensional structures from OCA and Proteopedia for RAB6B Gene

    Alternative splice isoforms for RAB6B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB6B Gene

Proteomics data for RAB6B Gene at MOPED

Post-translational modifications for RAB6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB6B Gene

No data available for DME Specific Peptides for RAB6B Gene

Domains & Families for RAB6B Gene

Gene Families for RAB6B Gene

Suggested Antigen Peptide Sequences for RAB6B Gene

Graphical View of Domain Structure for InterPro Entry

Q9NRW1

UniProtKB/Swiss-Prot:

RAB6B_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB6B: view

Function for RAB6B Gene

Molecular function for RAB6B Gene

UniProtKB/Swiss-Prot Function:
Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells.
genes like me logo Genes that share phenotypes with RAB6B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RAB6B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB6B Gene

Localization for RAB6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB6B Gene

Golgi apparatus membrane; Lipid-anchor. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasmic vesicle. Note=Colocalizes with BICD1 at vesicular structures that align along microtubules. {ECO:0000269 PubMed:17707369}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB6B Gene COMPARTMENTS Subcellular localization image for RAB6B gene
Compartment Confidence
golgi apparatus 5
cytosol 3
nucleus 2
endosome 1

Gene Ontology (GO) - Cellular Components for RAB6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA --
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with RAB6B: view

Pathways & Interactions for RAB6B Gene

genes like me logo Genes that share pathways with RAB6B: view

Gene Ontology (GO) - Biological Process for RAB6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
GO:0042147 retrograde transport, endosome to Golgi IBA --
genes like me logo Genes that share ontologies with RAB6B: view

No data available for SIGNOR curated interactions for RAB6B Gene

Drugs & Compounds for RAB6B Gene

No Compound Related Data Available

Transcripts for RAB6B Gene

Unigene Clusters for RAB6B Gene

RAB6B, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB6B Gene

No ASD Table

Relevant External Links for RAB6B Gene

GeneLoc Exon Structure for
RAB6B
ECgene alternative splicing isoforms for
RAB6B

Expression for RAB6B Gene

mRNA expression in normal human tissues for RAB6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB6B Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.1), Brain - Anterior cingulate cortex (BA24) (x6.4), and Brain - Cortex (x4.4).

Protein differential expression in normal tissues from HIPED for RAB6B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.7), Platelet (11.3), Brain (8.5), and Frontal cortex (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB6B Gene



SOURCE GeneReport for Unigene cluster for RAB6B Gene Hs.715344

mRNA Expression by UniProt/SwissProt for RAB6B Gene

Q9NRW1-RAB6B_HUMAN
Tissue specificity: Predominantly expressed in brain.
genes like me logo Genes that share expression patterns with RAB6B: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for RAB6B Gene

Orthologs for RAB6B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB6B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB6B 35
  • 99.46 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia RAB6B 35
  • 94.55 (n)
  • 100 (a)
RAB6B 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB6B 36
  • 100 (a)
OneToOne
RAB6B 35
  • 93.51 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Rab6b 16
Rab6b 36
  • 100 (a)
OneToOne
Rab6b 35
  • 92.31 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia RAB6B 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB6B 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab6b 35
  • 92.95 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 80 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 87 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rab6b 35
  • 79.01 (n)
  • 93.75 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3014 35
zebrafish
(Danio rerio)
Actinopterygii rab6ba 36
  • 96 (a)
OneToMany
rab6bb 36
  • 90 (a)
OneToMany
rab6b 35
  • 79.33 (n)
  • 95.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab6 37
  • 84 (a)
Rab6 36
  • 84 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C56E6.2 37
  • 37 (a)
rab-6.2 36
  • 82 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR257C 35
  • 60.07 (n)
  • 66.15 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT6 35
  • 58.54 (n)
  • 65.48 (a)
YPT6 36
  • 60 (a)
OneToMany
YPT6 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20471g 35
  • 58.88 (n)
  • 63.96 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05234 35
  • 64.72 (n)
  • 71.36 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ryh1 35
  • 62.46 (n)
  • 76.26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10389 36
  • 86 (a)
OneToMany
Species with no ortholog for RAB6B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB6B Gene

ENSEMBL:
Gene Tree for RAB6B (if available)
TreeFam:
Gene Tree for RAB6B (if available)

Paralogs for RAB6B Gene

Paralogs for RAB6B Gene

genes like me logo Genes that share paralogs with RAB6B: view

Variants for RAB6B Gene

Sequence variations from dbSNP and Humsavar for RAB6B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs940899 -- 133,897,357(-) CTTCA(A/G)CCCCA upstream-variant-2KB
rs940900 -- 133,897,291(-) GGAGG(A/G)TTACC upstream-variant-2KB
rs884224 -- 133,860,230(+) ACATA(C/T)GATTA intron-variant
rs1104916 -- 133,896,702(+) GAGTG(A/G)GTGAG upstream-variant-2KB
rs1358019 -- 133,882,670(-) GCTGG(A/G)TGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB6B Gene

Variant ID Type Subtype PubMed ID
nsv877506 CNV Gain 21882294
nsv829729 CNV Loss 17160897

Variation tolerance for RAB6B Gene

Residual Variation Intolerance Score: 29.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB6B Gene

HapMap Linkage Disequilibrium report
RAB6B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB6B Gene

Disorders for RAB6B Gene

Relevant External Links for RAB6B

Genetic Association Database (GAD)
RAB6B
Human Genome Epidemiology (HuGE) Navigator
RAB6B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB6B

No disorders were found for RAB6B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB6B Gene

Publications for RAB6B Gene

  1. The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus. (PMID: 10893188) Opdam F.J.M. … Fransen J.A.M. (J. Cell Sci. 2000) 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. (PMID: 24332808) Marechal A. … Zou L. (Mol. Cell 2014) 3
  5. Identification and characterization of multiple novel Rab-myosin Va interactions. (PMID: 24006491) Lindsay A.J. … Goud B. (Mol. Biol. Cell 2013) 3

Products for RAB6B Gene

Sources for RAB6B Gene

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