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RAB6B Gene

protein-coding   GIFtS: 49

GC03M135025
RAB6B, member RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Descriptions
RAB6B, member RAS oncogene family 2
small GTP-binding protein 2
small GTPase RAB6B 2
External Ids
HGNC: 149021
Entrez Gene: 515602
UniProtKB: Q9NRW13
Ensembl: ENSG000001549177
Search outside databases for aliases for RAB6B gene

Previous GC identifers: GC03M130506 GC03M134292 GC03M134828 GC03M134868

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: RAB6B_HUMAN, Q9NRW1
Function: Seems to have a role in retrograde membrane traffic at the level of the Golgi complex

Gene Wiki entry for RAB6B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RAB6B gene  

Entrez Gene cytogenetic band: 3q22.1   Ensembl cytogenetic band:  3q22.1   HGNC cytogenetic band: 3q22.1

RAB6B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M135025:     (about GC identifiers)

Start:
135,025,769 bp from pter
End:
135,097,381 bp from pter
Size:
71,613 bases
Orientation:
minus strand
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RAB6B_HUMAN, Q9NRW1 (See protein sequence)
Recommended Name: Ras-related protein Rab-6B  
Size: 208 amino acids; 23462 Da
Subunit: Interacts with RAB6KIFL
Subcellular location: Golgi apparatus membrane; Lipid-anchor
PDB structures from and Proteopedia :
2E9S (3D)    2FE4 (3D)    2FFQ (3D)    

REFSEQ proteins: NP_057661.3  

ENSEMBL proteins: 
ENSP00000285208 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Human Recombinant Proteins from Abnova (RAB6B)
              OriGene Purified Recombinant Human Protein: RAB6B 

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000139 Golgi membrane IEA--
GO:0005794 Golgi apparatus NAS10893188
GO:0016020 membrane IEA--
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Antibodies for RAB6B: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for RAB6B

Assays for RAB6B: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro domains/families:
 IPR015600 Rab6-like
 IPR001806 Ras_GTPase
 IPR005225 Small_GTP_bd
 IPR003579 GTPase_Rab
 IPR013753 Ras


   GeneDecks  RAB6B for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q9NRW1

ProtoNet protein and cluster: Q9NRW1

1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature

UniProtKB/Swiss-Prot: RAB6B_HUMAN, Q9NRW1
Similarity: Belongs to the small GTPase superfamily. Rab family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (RAB6B)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (RAB6B)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016577

              Applied Biosystems Silencer® siRNAs for RAB6B

              Sigma-Aldrich siRNA for RAB6B  
                     Sigma-Aldrich shRNA for RAB6B  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_016577
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_016577
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_016577 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_016577

UniProtKB/Swiss-Prot: RAB6B_HUMAN, Q9NRW1
Function: Seems to have a role in retrograde membrane traffic at the level of the Golgi complex

4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rab6b):

adipose tissuebehavior/neurologicalgrowth/sizeimmune system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000166 nucleotide binding IEA--
GO:0003924 GTPase activity NAS10893188
GO:0005525 GTP binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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 Gene Network CentralTM Interacting Genes and Proteins Network for  RAB6B 


2 Interacting proteins for RAB6B (ENSP000002852083) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
TXNENSP000003636413STRING (score=.883)
KIF20AENSP000002309023STRING (score=.866)
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4 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER NAS10893188
GO:0007264 small GTPase mediated signal transduction IEA--
GO:0015031 protein transport IEA--
GO:0016192 vesicle-mediated transport IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for RAB6B
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RAB6B

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (RAB6B)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (RAB6B)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016577

              Sigma-Aldrich siRNA for RAB6B  
                     Sigma-Aldrich shRNA for RAB6B  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_016577  

REFSEQ mRNAs for RAB6B gene: 

NM_016577.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_016577  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_016577
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_016577
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_016577 

24/188 AceView cDNA sequences (see all 188 ):

AI671352 AI435467 AA443303 BM668169 BM930021 W20198 AI140719 Z41808 
BM697592 CA430280 AW071907 AI701458 BC078662 BX460481 BU679746 BC002510 
AI631982 AL138062 BQ276245 AI375892 BM921926 AK055102 BM697396 AW779669 

highest scoring ESTs for RAB6B:

AK057826 BQ338060 DA188066 DA216451 DA217975 DA221889 DA497755 DA533821 R40392 AF166492 


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000285208  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RAB6B expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for RAB6B

1 / 2 / 3

9 probe-sets matching RAB6B gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
52962_g_at2, 3 U95-B 1 1.00 1.00 0.85 0.71 AA443437 0.40 0.67 0.55 1
36049_at2, 3 U95-A 1 1.00 1.00 0.93 0.99 W27899 0.40 0.67 0.55 1

52959_at2, 3 U95-B 1 0.94 1.00 0.93 1.35 AA443437 0.40 0.67 0.55 1

225259_at2, 3 U133-B 1 1.00 1.00 -- -- AI805050 0.20 0.50 0.38 1

210127_at2, 3 U133-A 1 1.00 1.00 -- -- BC002510 0.60 0.75 0.68 1

221792_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

225259_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

210127_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

221792_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  RAB6B for binary patterns associated with the probe-sets selected above  
About GeneDecksing
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Data from (Publications) and GNF BioGPS
    About these images
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CGAP SAGE TAG: TTGGTCAAAC

UniProtKB/Swiss-Prot: RAB6B_HUMAN, Q9NRW1
Tissue specificity: Predominantly expressed in brain

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for RAB6B gene from 5/17 species (see all 17 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
RAB6B1   -- RAB6B, member RAS oncogene family 92.87(n)
98.93(a)
610830  XM_848388.1  XP_853481.1 
chimpanzee
(Pan troglodytes)
RAB6B1   -- RAB6B, member RAS oncogene family 98.92(n)
100(a)
743801  XM_001147918.1  XP_001147918.1 
cow
(Bos taurus)
RAB6B1   -- RAB6B, member RAS oncogene family 94.39(n)
100(a)
526526  XM_604898.3  XP_604898.3 
rat
(Rattus norvegicus)
Rab6b1   -- RAB6B, member RAS oncogene family 92.95(n)
100(a)
363123  XM_343459.3  XP_343460.3 
mouse
(Mus musculus)
Rab6b1, 5 9 (56.00 cM)5
RAB6B, member RAS oncogene family1, 5 92.31(n)1
100(a)1
2701921  NM_173781.41  NP_776142.11 
 AB2325975  AI8442545  (see all 15)
About this table        Species with no ortholog for RAB6B

ENSEMBL Gene Tree for RAB6B
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for RAB6B gene
RAB202  RAB212  RAB6C2  RAB412  RAB6A2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/400 NCBI SNPs in RAB6B are shown (see all 400 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 164)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 3 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs9408981,2
A,C,F,H,O135099061(-) GATGAG/AAGGGT 1 -- ng3112Minor allele frequency- A:0.29EA NA EU WA 2316
rs10431471,2
A,C,F,H135027688(-) CTCAGT/CGGTTC 1 -- ut31 ese34Minor allele frequency- C:0.28EU EA WA 418
rs26926771,2
A,C,F,H135097953(-) GCGCCT/CGATAT 1 -- ng318Minor allele frequency- C:0.42EU EA WA 838
rs22933751,2
A,C,F,H135029906(-) GAACCA/GTTCAT 1 -- ut319Minor allele frequency- G:0.40EA EU WA NA 2118
rs9408991,2
A,C,F,H135098891(-) CTTCAA/GCCCCA 1 -- ng314Minor allele frequency- G:0.02EU EA WA 420
rs168409941,2
C,F,H135025392(+) GAAGCA/CTGAGA 1 -- ng5111Minor allele frequency- C:0.21NA EU EA WA 982
rs9409001,2
A,C,F135098825(-) GGAGGA/GTTACC 1 -- ng313Minor allele frequency- G:0.48NA EA 252
rs26926761,2
A,C,F135099180(-) TGTGCG/AGGACC 1 -- ng311Minor allele frequency- A:0.33EA 1310
rs76264331,2
A,F,H135026607(+) TGTGCG/ACACAA 1 -- ut31 ese33Minor allele frequency- A:0.33EA WA 298
rs126377301,2
C,F,H135028987(+) CTCTTC/TAGAGA 1 -- ut31 ese34Minor allele frequency- T:0.19EU EA WA 418
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HapMap Linkage Disequilibrium images for RAB6B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

  --

(Possibly Related Articles in Doctor's Guide)
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  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10 PubMed articles for RAB6B gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 51560 HGNC: 14902 AceView: RAB6B Ensembl:ENSG00000154917 euGenes: HUgn51560
ECgene: RAB6B H-InvDB: RAB6B
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for RAB6B Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for RAB6B:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for RAB6B-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for RAB6B Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for RAB6B Browse small molecules at Sigma-Aldrich
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 Recombinant & Natural Proteins  

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 Drugs for RAB6B
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 Search Novus for antibodies for RAB6B

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