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Aliases for RAB6B Gene

Aliases for RAB6B Gene

  • RAB6B, Member RAS Oncogene Family 2 3 5

External Ids for RAB6B Gene

Previous GeneCards Identifiers for RAB6B Gene

  • GC03M130506
  • GC03M134292
  • GC03M134828
  • GC03M134868
  • GC03M135025
  • GC03M133543
  • GC03M130921

Summaries for RAB6B Gene

GeneCards Summary for RAB6B Gene

RAB6B (RAB6B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Golgi-to-ER retrograde transport. GO annotations related to this gene include GTP binding and myosin V binding. An important paralog of this gene is RAB6A.

UniProtKB/Swiss-Prot for RAB6B Gene

  • Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells.

Gene Wiki entry for RAB6B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB6B Gene

Genomics for RAB6B Gene

Regulatory Elements for RAB6B Gene

Enhancers for RAB6B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G133895 0.9 ENCODE 15.3 +0.0 11 1.0 RB1 ZNF76 KLF17 ZNF121 EGR1 ZNF366 EGR2 ZNF263 SP3 ZNF398 RAB6B TFP1 GC03M133818
GH03G134347 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5 -466.0 -465995 29.3 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 FEZF1 ZNF2 ZBTB7B YY1 ENSG00000260633 TFP1 RYK RAB6B AMOTL2 MIR6827 RPL39P5
GH03G133568 1.7 FANTOM5 ENCODE dbSUPER 5 +323.5 323490 9.0 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YBX1 FEZF1 YY1 SLC30A9 SRPRB TFP1 CDV3 RAB6B NPHP3 UBA5 GC03P133569
GH03G133879 0.7 ENCODE 4.9 +14.1 14131 4.0 ESRRA USF1 CTBP1 ZNF316 SCRT2 FOSL2 FOS NFE2 MAFK SCRT1 C3orf36 RAB6B GC03M133818
GH03G133926 1.1 Ensembl ENCODE 0.3 -31.6 -31557 1.6 PKNOX1 RB1 ARNT RAD21 EGR1 ZNF143 BCLAF1 GATAD2B REST GLIS1 C3orf36 RAB6B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAB6B on UCSC Golden Path with GeneCards custom track

Promoters for RAB6B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000158655 347 1001 RB1 ZNF76 KLF17 ZNF121 GLIS2 EGR1 ZNF366 EGR2 SP3 ZNF398

Genomic Location for RAB6B Gene

Chromosome:
3
Start:
133,824,235 bp from pter
End:
133,895,847 bp from pter
Size:
71,613 bases
Orientation:
Minus strand

Genomic View for RAB6B Gene

Genes around RAB6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB6B Gene

Proteins for RAB6B Gene

  • Protein details for RAB6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRW1-RAB6B_HUMAN
    Recommended name:
    Ras-related protein Rab-6B
    Protein Accession:
    Q9NRW1
    Secondary Accessions:
    • B2R5Z9
    • B7Z337
    • D3DND3
    • Q92929

    Protein attributes for RAB6B Gene

    Size:
    208 amino acids
    Molecular mass:
    23462 Da
    Quaternary structure:
    • Interacts with BICDL1/BICDR1; leads to its accumulation in the pericentrosomal region (By similarity). Interacts with RAB6KIFL. Interacts (GTP-bound) with BICD1 (via C-terminus); the interaction is direct. Interacts (GDP-bound) with DYNLRB1. Interacts (GTP-bound) with APBA1/MINT1 isoform 2, also called Mint1_826, but not with isoform 1.

    Three dimensional structures from OCA and Proteopedia for RAB6B Gene

    Alternative splice isoforms for RAB6B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB6B Gene

Post-translational modifications for RAB6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAB6B Gene

Domains & Families for RAB6B Gene

Gene Families for RAB6B Gene

Protein Domains for RAB6B Gene

Suggested Antigen Peptide Sequences for RAB6B Gene

Graphical View of Domain Structure for InterPro Entry

Q9NRW1

UniProtKB/Swiss-Prot:

RAB6B_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB6B: view

Function for RAB6B Gene

Molecular function for RAB6B Gene

UniProtKB/Swiss-Prot Function:
Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells.

Gene Ontology (GO) - Molecular Function for RAB6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity NAS 10893188
GO:0005515 protein binding IPI 23737971
GO:0005525 GTP binding IEA --
GO:0031489 myosin V binding IPI 24006491
genes like me logo Genes that share ontologies with RAB6B: view
genes like me logo Genes that share phenotypes with RAB6B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RAB6B

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB6B Gene

Localization for RAB6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB6B Gene

Golgi apparatus membrane; Lipid-anchor. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasmic vesicle. Note=Colocalizes with BICD1 at vesicular structures that align along microtubules. {ECO:0000269 PubMed:17707369}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB6B gene
Compartment Confidence
golgi apparatus 5
cytosol 4
nucleus 2
endosome 1

Gene Ontology (GO) - Cellular Components for RAB6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005622 intracellular IEA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA --
GO:0005794 Golgi apparatus IDA,NAS 10893188
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with RAB6B: view

Pathways & Interactions for RAB6B Gene

genes like me logo Genes that share pathways with RAB6B: view

Gene Ontology (GO) - Biological Process for RAB6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER NAS 10893188
GO:0006891 intra-Golgi vesicle-mediated transport IBA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with RAB6B: view

No data available for SIGNOR curated interactions for RAB6B Gene

Drugs & Compounds for RAB6B Gene

No Compound Related Data Available

Transcripts for RAB6B Gene

Unigene Clusters for RAB6B Gene

RAB6B, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB6B Gene

No ASD Table

Relevant External Links for RAB6B Gene

GeneLoc Exon Structure for
RAB6B
ECgene alternative splicing isoforms for
RAB6B

Expression for RAB6B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB6B Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.1), Brain - Anterior cingulate cortex (BA24) (x6.4), and Brain - Cortex (x4.4).

Protein differential expression in normal tissues from HIPED for RAB6B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.7), Platelet (11.3), Brain (8.5), and Frontal cortex (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB6B Gene



NURSA nuclear receptor signaling pathways regulating expression of RAB6B Gene:

RAB6B

SOURCE GeneReport for Unigene cluster for RAB6B Gene:

Hs.715344

mRNA Expression by UniProt/SwissProt for RAB6B Gene:

Q9NRW1-RAB6B_HUMAN
Tissue specificity: Predominantly expressed in brain.

Evidence on tissue expression from TISSUES for RAB6B Gene

  • Nervous system(5)
  • Skin(4.1)
  • Eye(2.2)
  • Lung(2)
genes like me logo Genes that share expression patterns with RAB6B: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB6B Gene

Orthologs for RAB6B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB6B Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia RAB6B 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAB6B 34
  • 99.46 (n)
cow
(Bos Taurus)
Mammalia RAB6B 34 35
  • 94.55 (n)
dog
(Canis familiaris)
Mammalia RAB6B 34 35
  • 93.51 (n)
rat
(Rattus norvegicus)
Mammalia Rab6b 34
  • 92.95 (n)
mouse
(Mus musculus)
Mammalia Rab6b 34 16 35
  • 92.31 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RAB6B 35
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 80 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 87 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rab6b 34
  • 79.01 (n)
zebrafish
(Danio rerio)
Actinopterygii rab6ba 35
  • 96 (a)
OneToMany
rab6bb 35
  • 90 (a)
OneToMany
rab6b 34
  • 79.33 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3014 34
fruit fly
(Drosophila melanogaster)
Insecta Rab6 36 35
  • 84 (a)
worm
(Caenorhabditis elegans)
Secernentea rab-6.2 35
  • 82 (a)
OneToMany
C56E6.2 36
  • 37 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR257C 34
  • 60.07 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20471g 34
  • 58.88 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT6 34 35 37
  • 58.54 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10389 35
  • 86 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU05234 34
  • 64.72 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ryh1 34
  • 62.46 (n)
Species where no ortholog for RAB6B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB6B Gene

ENSEMBL:
Gene Tree for RAB6B (if available)
TreeFam:
Gene Tree for RAB6B (if available)

Paralogs for RAB6B Gene

Paralogs for RAB6B Gene

genes like me logo Genes that share paralogs with RAB6B: view

Variants for RAB6B Gene

Sequence variations from dbSNP and Humsavar for RAB6B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000286894 -- 133,862,226(+) CTTGA(G/T)CTGAT intron-variant
rs1000317776 -- 133,868,286(+) TCTCA(A/G)TCCCC intron-variant
rs1000326865 -- 133,840,751(+) GCAGT(C/T)CTGTT intron-variant
rs1000356580 -- 133,844,607(+) AAATA(C/T)AAGAA intron-variant
rs1000360186 -- 133,862,487(+) GAGGA(A/T)GAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB6B Gene

Variant ID Type Subtype PubMed ID
esv3413841 CNV duplication 20981092
esv3569012 CNV loss 25503493
nsv829729 CNV loss 17160897
nsv955349 CNV deletion 24416366

Variation tolerance for RAB6B Gene

Residual Variation Intolerance Score: 29.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB6B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB6B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB6B Gene

Disorders for RAB6B Gene

Relevant External Links for RAB6B

Genetic Association Database (GAD)
RAB6B
Human Genome Epidemiology (HuGE) Navigator
RAB6B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB6B

No disorders were found for RAB6B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB6B Gene

Publications for RAB6B Gene

  1. The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus. (PMID: 10893188) Opdam F.J.M. … Fransen J.A.M. (J. Cell Sci. 2000) 3 4 22 64
  2. A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6. (PMID: 23737971) Thyrock A. … Barnekow A. (PLoS ONE 2013) 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Rab6 family proteins interact with the dynein light chain protein DYNLRB1. (PMID: 18044744) Wanschers B.F.J. … Fransen J. (Cell Motil. Cytoskeleton 2008) 3 4 64
  5. A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells. (PMID: 17707369) Wanschers B.F.J.F. … Fransen J.A. (Exp. Cell Res. 2007) 3 4 64

Products for RAB6B Gene

Sources for RAB6B Gene

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