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Aliases & Descriptions for RAB6B
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| RAB6B, member RAS oncogene family 2 | | small GTP-binding protein 2 | | small GTPase RAB6B 2 |
|
| | Search outside databases for aliases for RAB6B genePrevious GC identifers: GC03M130506 GC03M134292 GC03M134828 GC03M134868 |
Summaries for RAB6B(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: RAB6B_HUMAN, Q9NRW1Function: Seems to have a role in retrograde membrane traffic at the level of the Golgi complexGene Wiki entry for RAB6B |
Genomic Location for RAB6B
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RAB6B gene 
Entrez Gene cytogenetic band: 3q22.1 Ensembl cytogenetic band: 3q22.1 HGNC cytogenetic band: 3q22.1RAB6B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M135025:
(about GC identifiers)
Start:
|
135,025,769 bp from pter |
End:
|
135,097,381 bp from pter |
Size:
|
71,613 bases |
Orientation:
|
minus strand |
| Proteins for RAB6B
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RAB6B_HUMAN, Q9NRW1 (See
protein sequence)Recommended Name: Ras-related protein Rab-6B Size: 208 amino acids; 23462 Da
Subunit: Interacts with RAB6KIFL
Subcellular location: Golgi apparatus membrane; Lipid-anchor
PDB structures from and Proteopedia :2E9S (3D)
 2FE4 (3D)
 2FFQ (3D)
 REFSEQ proteins: NP_057661.3
ENSEMBL proteins: ENSP00000285208
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: RAB6B 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for RAB6B: Assays for RAB6B: | Protein
Domains/ Families for RAB6B(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9NRW1
ProtoNet protein and cluster: Q9NRW1 1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: RAB6B_HUMAN, Q9NRW1Similarity: Belongs to the small GTPase superfamily. Rab family | Gene Function for RAB6B
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016577
Applied Biosystems Silencer® siRNAs for RAB6B
Sigma-Aldrich siRNA for RAB6B  Sigma-Aldrich shRNA for RAB6B  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_016577                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016577                                  untagged cDNA clones in CMV expression vector (see all 2): NM_016577 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_016577
UniProtKB/Swiss-Prot: RAB6B_HUMAN, Q9NRW1Function: Seems to have a role in retrograde membrane traffic at the level of the Golgi complex4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Rab6b):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for RAB6B
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for RAB6B 
2 Interacting proteins for RAB6B (ENSP000002852083) via UniProtKB, MINT, and/or STRINGAbout this table
4 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER |
NAS | 10893188 | | GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- | | GO:0016192 | vesicle-mediated transport |
IEA | -- | About this table
|
Drugs & Compounds for RAB6B(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for RAB6B |
Browse Tocris compounds for RAB6B
|
Transcripts for RAB6B(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016577
Sigma-Aldrich siRNA for RAB6B  Sigma-Aldrich shRNA for RAB6B  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_016577 REFSEQ mRNAs for RAB6B gene: NM_016577.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_016577               OriGene GFP tagged cDNA clone in CMV expression vector: NM_016577                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016577                                  untagged cDNA clones in CMV expression vector (see all 2): NM_016577  24/188 AceView cDNA sequences (see all 188
):AI671352 AI435467 AA443303 BM668169 BM930021 W20198 AI140719 Z41808 BM697592 CA430280 AW071907 AI701458 BC078662 BX460481 BU679746 BC002510 AI631982 AL138062 BQ276245 AI375892 BM921926 AK055102 BM697396 AW779669
highest scoring ESTs for RAB6B:AK057826 BQ338060 DA188066 DA216451 DA217975 DA221889 DA497755 DA533821 R40392 AF166492
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000285208
|
Expression for RAB6B
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RAB6B expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RAB6B
1 / 2 / 3 9 probe-sets matching RAB6B gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TTGGTCAAAC UniProtKB/Swiss-Prot: RAB6B_HUMAN, Q9NRW1Tissue specificity: Predominantly expressed in brain |
Orthologs for RAB6B
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB6B gene from 5/17 species (see all 17
)
About this table Species with no ortholog for RAB6B
ENSEMBL Gene Tree for RAB6B | Paralogs for RAB6B(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RAB6B gene
- RAB202 RAB212 RAB6C2 RAB412 RAB6A2
|
SNPs/Variants for RAB6B(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RAB6B (up to first 250kb)
|
Disorders & Mutations for RAB6B
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for RAB6B(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RAB6B (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10 PubMed articles for RAB6B gene: |
Search for RAB6B
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RAB6B
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RAB6B
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB6B(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RAB6B(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RAB6B:

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Incremental update: 13 Oct 2009
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