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Aliases for RAB6B Gene

Aliases for RAB6B Gene

  • RAB6B, Member RAS Oncogene Family 2 3

External Ids for RAB6B Gene

Summaries for RAB6B Gene

GeneCards Summary for RAB6B Gene

RAB6B (RAB6B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB41.

UniProtKB/Swiss-Prot for RAB6B Gene

  • Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells.

Gene Wiki entry for RAB6B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB6B Gene

Genomics for RAB6B Gene

Genomic Location for RAB6B Gene

Start:
133,824,235 bp from pter
End:
133,895,847 bp from pter
Size:
71,613 bases
Orientation:
Minus strand

Genomic View for RAB6B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB6B Gene

Regulatory Elements for RAB6B Gene

Proteins for RAB6B Gene

  • Protein details for RAB6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRW1-RAB6B_HUMAN
    Recommended name:
    Ras-related protein Rab-6B
    Protein Accession:
    Q9NRW1
    Secondary Accessions:
    • B2R5Z9
    • B7Z337
    • D3DND3
    • Q92929

    Protein attributes for RAB6B Gene

    Size:
    208 amino acids
    Molecular mass:
    23462 Da
    Quaternary structure:
    • Interacts with CCDC64/BICDR1; leads to its accumulation in the pericentrosomal region (By similarity). Interacts with RAB6KIFL. Interacts (GTP-bound) with BICD1 (via C-terminus); the interaction is direct. Interacts (GDP-bound) with DYNLRB1. Interacts (GTP-bound) with APBA1/MINT1 isoform 2, also called Mint1_826, but not with isoform 1.

    Three dimensional structures from OCA and Proteopedia for RAB6B Gene

    Alternative splice isoforms for RAB6B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB6B Gene

Proteomics data for RAB6B Gene at MOPED

Post-translational modifications for RAB6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB6B Gene

No data available for DME Specific Peptides for RAB6B Gene

Domains for RAB6B Gene

Gene Families for RAB6B Gene

HGNC:
  • RAB :RAB, member RAS oncogene

UniProtKB/Swiss-Prot:

RAB6B_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rab family.:
    • Q9NRW1
genes like me logo Genes that share domains with RAB6B: view

Function for RAB6B Gene

Molecular function for RAB6B Gene

UniProtKB/Swiss-Prot Function: Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells.

Gene Ontology (GO) - Molecular Function for RAB6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 10893188
GO:0005515 protein binding IPI 23737971
GO:0005525 GTP binding IEA --
GO:0031489 myosin V binding IPI 24006491
genes like me logo Genes that share ontologies with RAB6B: view
genes like me logo Genes that share phenotypes with RAB6B: view

miRNA for RAB6B Gene

miRTarBase miRNAs that target RAB6B

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB6B Gene

Localization for RAB6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB6B Gene

Golgi apparatus membrane; Lipid-anchor. Cytoplasmic vesicle. Note=Colocalizes with BICD1 at vesicular structures that align along microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB6B Gene COMPARTMENTS Subcellular localization image for RAB6B gene
Compartment Confidence
golgi apparatus 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for RAB6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005794 Golgi apparatus NAS 10893188
genes like me logo Genes that share ontologies with RAB6B: view

Pathways for RAB6B Gene

genes like me logo Genes that share pathways with RAB6B: view

Pathways by source for RAB6B Gene

1 Qiagen pathway for RAB6B Gene

Gene Ontology (GO) - Biological Process for RAB6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER NAS 10893188
GO:0006891 intra-Golgi vesicle-mediated transport IBA --
GO:0006913 nucleocytoplasmic transport --
genes like me logo Genes that share ontologies with RAB6B: view

Transcripts for RAB6B Gene

Unigene Clusters for RAB6B Gene

RAB6B, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB6B Gene

No ASD Table

Relevant External Links for RAB6B Gene

GeneLoc Exon Structure for
RAB6B
ECgene alternative splicing isoforms for
RAB6B

Expression for RAB6B Gene

mRNA expression in normal human tissues for RAB6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB6B Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (7.1), Brain - Anterior cingulate cortex (BA24) (6.4), and Brain - Cortex (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB6B Gene

SOURCE GeneReport for Unigene cluster for RAB6B Gene Hs.715344

mRNA Expression by UniProt/SwissProt for RAB6B Gene

Q9NRW1-RAB6B_HUMAN
Tissue specificity: Predominantly expressed in brain
genes like me logo Genes that share expressions with RAB6B: view

Orthologs for RAB6B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB6B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB6B 36
  • 99.46 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia RAB6B 36
  • 94.55 (n)
  • 100 (a)
RAB6B 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB6B 36
  • 93.51 (n)
  • 100 (a)
RAB6B 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab6b 36
  • 92.31 (n)
  • 100 (a)
Rab6b 16
Rab6b 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB6B 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB6B 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab6b 36
  • 92.95 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 80 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 87 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rab6b 36
  • 79.01 (n)
  • 93.75 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3014 36
zebrafish
(Danio rerio)
Actinopterygii rab6b 36
  • 79.33 (n)
  • 95.19 (a)
rab6ba 37
  • 96 (a)
OneToMany
rab6bb 37
  • 90 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Rab6 37
  • 84 (a)
OneToMany
Rab6 38
  • 84 (a)
worm
(Caenorhabditis elegans)
Secernentea rab-6.2 37
  • 82 (a)
OneToMany
C56E6.2 38
  • 37 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR257C 36
  • 60.07 (n)
  • 66.15 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT6 36
  • 58.54 (n)
  • 65.48 (a)
YPT6 37
  • 60 (a)
OneToMany
YPT6 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20471g 36
  • 58.88 (n)
  • 63.96 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05234 36
  • 64.72 (n)
  • 71.36 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ryh1 36
  • 62.46 (n)
  • 76.26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10389 37
  • 86 (a)
OneToMany
Species with no ortholog for RAB6B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB6B Gene

ENSEMBL:
Gene Tree for RAB6B (if available)
TreeFam:
Gene Tree for RAB6B (if available)

Paralogs for RAB6B Gene

Paralogs for RAB6B Gene

genes like me logo Genes that share paralogs with RAB6B: view

Variants for RAB6B Gene

Sequence variations from dbSNP and Humsavar for RAB6B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs884224 -- 133,860,230(+) ACATA(C/T)GATTA intron-variant
rs940897 -- 133,839,252(+) GCACA(C/G)TGCTC intron-variant
rs940898 -- 133,897,527(-) GATGA(A/G)AGGGT upstream-variant-2KB
rs940899 -- 133,897,357(-) CTTCA(A/G)CCCCA upstream-variant-2KB
rs940900 -- 133,897,291(-) GGAGG(A/G)TTACC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RAB6B Gene

Variant ID Type Subtype PubMed ID
nsv877506 CNV Gain 21882294
nsv829729 CNV Loss 17160897

Relevant External Links for RAB6B Gene

HapMap Linkage Disequilibrium report
RAB6B

Disorders for RAB6B Gene

Relevant External Links for RAB6B

Genetic Association Database (GAD)
RAB6B
Human Genome Epidemiology (HuGE) Navigator
RAB6B
genes like me logo Genes that share disorders with RAB6B: view

No data available for UniProtKB/Swiss-Prot for RAB6B Gene

Publications for RAB6B Gene

  1. The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus. (PMID: 10893188) Opdam F.J.M. … Fransen J.A.M. (J. Cell Sci. 2000) 3 4 23
  2. RAB GTPases expressed in human melanoma cells. (PMID: 9030196) Chen D. … Gahl W.A. (Biochim. Biophys. Acta 1997) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The structure of human neuronal Rab6B in the active and inactive form. (PMID: 16790928) Garcia-Saez I. … Kozielski F. (Acta Crystallogr. D 2006) 3 4

Products for RAB6B Gene

Sources for RAB6B Gene

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