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Aliases for RAB6B Gene

Aliases for RAB6B Gene

  • RAB6B, Member RAS Oncogene Family 2 3 5

External Ids for RAB6B Gene

Previous GeneCards Identifiers for RAB6B Gene

  • GC03M130506
  • GC03M134292
  • GC03M134828
  • GC03M134868
  • GC03M135025
  • GC03M133543
  • GC03M130921

Summaries for RAB6B Gene

GeneCards Summary for RAB6B Gene

RAB6B (RAB6B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are RAB geranylgeranylation and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and myosin V binding. An important paralog of this gene is RAB6A.

UniProtKB/Swiss-Prot for RAB6B Gene

  • Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells.

Gene Wiki entry for RAB6B Gene

Additional gene information for RAB6B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB6B Gene

Genomics for RAB6B Gene

Regulatory Elements for RAB6B Gene

Enhancers for RAB6B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H133895 0.9 ENCODE 15.3 +0.0 11 1 RB1 ZNF76 KLF17 ZNF121 EGR1 ZNF366 ATF7 EGR2 SP3 ZNF398 RAB6B RYK TFP1 GC03M133818
GH03H134347 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5 -466.0 -465995 29.2 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 ENSG00000260633 RYK TOPBP1 TFP1 RAB6B AMOTL2 RPL39P5 MIR6827
GH03H133879 0.6 ENCODE 4.9 +14.1 14131 4 ZNF217 CTBP1 ESRRA FOSL2 FOS DPF2 C3orf36 RAB6B GC03M133818
GH03H133926 1.1 Ensembl ENCODE 0.3 -31.6 -31557 1.6 CTCF KLF1 RB1 ARNT BACH1 RAD21 CCNT2 FOXM1 ZFHX2 EGR1 C3orf36 RAB6B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAB6B on UCSC Golden Path with GeneCards custom track

Promoters for RAB6B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000158655 347 1001 RB1 ZNF76 KLF17 ZNF121 GLIS2 EGR1 ZNF366 ATF7 EGR2 SP3

Genomic Locations for RAB6B Gene

Genomic Locations for RAB6B Gene
71,613 bases
Minus strand

Genomic View for RAB6B Gene

Genes around RAB6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB6B Gene

Proteins for RAB6B Gene

  • Protein details for RAB6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-6B
    Protein Accession:
    Secondary Accessions:
    • B2R5Z9
    • B7Z337
    • D3DND3
    • Q92929

    Protein attributes for RAB6B Gene

    208 amino acids
    Molecular mass:
    23462 Da
    Quaternary structure:
    • Interacts with BICDL1/BICDR1; leads to its accumulation in the pericentrosomal region (By similarity). Interacts with RAB6KIFL. Interacts (GTP-bound) with BICD1 (via C-terminus); the interaction is direct. Interacts (GDP-bound) with DYNLRB1. Interacts (GTP-bound) with APBA1/MINT1 isoform 2, also called Mint1_826, but not with isoform 1.

    Three dimensional structures from OCA and Proteopedia for RAB6B Gene

    Alternative splice isoforms for RAB6B Gene


neXtProt entry for RAB6B Gene

Post-translational modifications for RAB6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAB6B Gene

Domains & Families for RAB6B Gene

Gene Families for RAB6B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAB6B Gene

Suggested Antigen Peptide Sequences for RAB6B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB6B: view

Function for RAB6B Gene

Molecular function for RAB6B Gene

UniProtKB/Swiss-Prot Function:
Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells.

Phenotypes From GWAS Catalog for RAB6B Gene

Gene Ontology (GO) - Molecular Function for RAB6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity NAS 10893188
GO:0005515 protein binding IPI 23737971
GO:0005525 GTP binding IEA --
GO:0031489 myosin V binding IPI 24006491
genes like me logo Genes that share ontologies with RAB6B: view
genes like me logo Genes that share phenotypes with RAB6B: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB6B Gene

Localization for RAB6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB6B Gene

Golgi apparatus membrane; Lipid-anchor. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasmic vesicle. Note=Colocalizes with BICD1 at vesicular structures that align along microtubules. {ECO:0000269 PubMed:17707369}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB6B gene
Compartment Confidence
golgi apparatus 5
cytosol 4
nucleus 2
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RAB6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA --
GO:0005794 Golgi apparatus IBA,NAS 10893188
GO:0005829 cytosol IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RAB6B: view

Pathways & Interactions for RAB6B Gene

genes like me logo Genes that share pathways with RAB6B: view

Gene Ontology (GO) - Biological Process for RAB6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IBA,NAS 10893188
GO:0006891 intra-Golgi vesicle-mediated transport IBA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with RAB6B: view

No data available for SIGNOR curated interactions for RAB6B Gene

Drugs & Compounds for RAB6B Gene

No Compound Related Data Available

Transcripts for RAB6B Gene

Unigene Clusters for RAB6B Gene

RAB6B, member RAS oncogene family:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB6B Gene

No ASD Table

Relevant External Links for RAB6B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB6B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB6B Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.1), Brain - Anterior cingulate cortex (BA24) (x6.4), and Brain - Cortex (x4.4).

Protein differential expression in normal tissues from HIPED for RAB6B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.7), Platelet (11.3), Brain (8.5), and Frontal cortex (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB6B Gene

NURSA nuclear receptor signaling pathways regulating expression of RAB6B Gene:


SOURCE GeneReport for Unigene cluster for RAB6B Gene:


mRNA Expression by UniProt/SwissProt for RAB6B Gene:

Tissue specificity: Predominantly expressed in brain.

Evidence on tissue expression from TISSUES for RAB6B Gene

  • Nervous system(5)
  • Skin(4.1)
  • Eye(2.2)
  • Lung(2)
genes like me logo Genes that share expression patterns with RAB6B: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB6B Gene

Orthologs for RAB6B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB6B Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia RAB6B 34
  • 100 (a)
(Pan troglodytes)
Mammalia RAB6B 33
  • 99.46 (n)
(Bos Taurus)
Mammalia RAB6B 33 34
  • 94.55 (n)
(Canis familiaris)
Mammalia RAB6B 33 34
  • 93.51 (n)
(Rattus norvegicus)
Mammalia Rab6b 33
  • 92.95 (n)
(Mus musculus)
Mammalia Rab6b 33 16 34
  • 92.31 (n)
(Ornithorhynchus anatinus)
Mammalia RAB6B 34
  • 92 (a)
(Gallus gallus)
Aves -- 34
  • 80 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab6b 33
  • 79.01 (n)
(Danio rerio)
Actinopterygii rab6ba 34
  • 96 (a)
rab6bb 34
  • 90 (a)
rab6b 33
  • 79.33 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3014 33
fruit fly
(Drosophila melanogaster)
Insecta Rab6 35 34
  • 84 (a)
(Caenorhabditis elegans)
Secernentea rab-6.2 34
  • 82 (a)
C56E6.2 35
  • 37 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR257C 33
  • 60.07 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20471g 33
  • 58.88 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT6 33 34 36
  • 58.54 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10389 34
  • 86 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05234 33
  • 64.72 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ryh1 33
  • 62.46 (n)
Species where no ortholog for RAB6B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB6B Gene

Gene Tree for RAB6B (if available)
Gene Tree for RAB6B (if available)

Paralogs for RAB6B Gene

Paralogs for RAB6B Gene

genes like me logo Genes that share paralogs with RAB6B: view

Variants for RAB6B Gene

Sequence variations from dbSNP and Humsavar for RAB6B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000286894 -- 133,862,226(+) CTTGA(G/T)CTGAT intron-variant
rs1000317776 -- 133,868,286(+) TCTCA(A/G)TCCCC intron-variant
rs1000326865 -- 133,840,751(+) GCAGT(C/T)CTGTT intron-variant
rs1000356580 -- 133,844,607(+) AAATA(C/T)AAGAA intron-variant
rs1000360186 -- 133,862,487(+) GAGGA(A/T)GAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB6B Gene

Variant ID Type Subtype PubMed ID
nsv955349 CNV deletion 24416366
nsv829729 CNV loss 17160897
esv3569012 CNV loss 25503493
esv3413841 CNV duplication 20981092

Variation tolerance for RAB6B Gene

Residual Variation Intolerance Score: 29.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB6B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB6B Gene

Disorders for RAB6B Gene

Relevant External Links for RAB6B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RAB6B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB6B Gene

Publications for RAB6B Gene

  1. The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus. (PMID: 10893188) Opdam FJ … Fransen JA (Journal of cell science 2000) 3 4 22 60
  2. A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6. (PMID: 23737971) Thyrock A … Barnekow A (PloS one 2013) 3 4 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Rab6 family proteins interact with the dynein light chain protein DYNLRB1. (PMID: 18044744) Wanschers B … Fransen J (Cell motility and the cytoskeleton 2008) 3 4 60
  5. A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells. (PMID: 17707369) Wanschers BF … Fransen JA (Experimental cell research 2007) 3 4 60

Products for RAB6B Gene

Sources for RAB6B Gene

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