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Aliases & Descriptions for RAB6A
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases RAB6 2 , 3 , 5 RAB6A' 2 RAB6B 2 Rab-6 3
Descriptions GTP-binding protein RAB6A' 2 GTP-binding protein RAB6B 2 Oncogene RAB6 2 RAB6, member RAS oncogene family 2 RAB6A, member RAS oncogene family 2 Rab GTPase 2 Rab6A variant 3 2
Search outside databases for aliases for RAB6A genePrevious GC identifers: GC11M075714 GC11M074926 GC11M073609 GC11M073113 GC11M073112
Summaries for RAB6A (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: RAB6A_HUMAN, P20340 Function : Protein transport. Regulator of membrane traffic from the Golgi apparatus towards theendoplasmic reticulum (ER). Has a low GTPase activity
Gene Wiki entry for RAB6A
Genomic Location for RAB6A
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the RAB6A gene Entrez Gene cytogenetic band: 11q13.3 Ensembl cytogenetic band: 11q13.4 HGNC cytogenetic band: 11q13.3 RAB6A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11M073064:
(about GC identifiers )
Start:
73,064,331 bp from pter
End:
73,149,849 bp from pter
Size:
85,519 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000011.8 NT_033927.7 Proteins for RAB6A
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: RAB6A_HUMAN, P20340 (See
protein sequence )Recommended Name: Ras-related protein Rab-6A Size : 208 amino acids; 23593 Da
Subunit : Interacts with SCYL1BP1. Interacts with VSP52 and RABGAP1. Isoform 1 interacts withRAB6KIFL but not isoform 2. Isoforms 1 and 2 interact with BICD1 and BICD2. Interacts with TMF1
Subcellular location : Golgi apparatus membrane; Lipid-anchor
PDB structures from and Proteopedia : 1YZQ (3D)
 2GIL (3D)
 3BBP (3D)
 3CWZ (3D)
 
Secondary accessions : A8K133 Q5U0A8 Q9UBE4Alternative splicing : 2 isoforms : P20340-1 P20340-2
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity)1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_002860.2 NP_942599.1 ENSEMBL proteins: ENSP00000377201 ENSP00000336850 ENSP00000311449 Human Recombinant Proteins                OriGene Purified Recombinant Human Proteins (see all 2 ): RAB6A 3 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for RAB6A: Assays for RAB6A:
Protein
Domains/ Families for RAB6A(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P20340 ProtoNet protein and cluster: P20340
1 Blocks protein family : IPB001806 Transforming protein P21 RAS signature UniProtKB/Swiss-Prot: RAB6A_HUMAN, P20340 Similarity : Belongs to the small GTPase superfamily. Rab family
Gene Function for RAB6A
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_002869 Applied Biosystems Silencer ® siRNAs for RAB6A Browse siRNA at Sigma-Aldrich Sigma-Aldrich shRNA for RAB6A Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_002869                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_002869                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_002869  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_198896 UniProtKB/Swiss-Prot: RAB6A_HUMAN, P20340 Function : Protein transport. Regulator of membrane traffic from the Golgi apparatus towards theendoplasmic reticulum (ER). Has a low GTPase activity
4 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for RAB6A
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for RAB6A 5/25 Interacting proteins for RAB6A (ENSP00000336850 3 P20340 1 , 2 ) via UniProtKB, MINT, and/or STRING (see all 25
)About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0007264 small GTPase mediated signal transduction
IEA -- GO:0015031 protein transport
IEA -- GO:0016192 vesicle-mediated transport
IEA --
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Drugs & Compounds for RAB6A (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Enzo Life Sciences drugs & compounds for RAB6A
Browse Tocris compounds for RAB6A 10/11 Novoseek chemical compound relationships for RAB6A gene (see all 11
)
Compound
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
gdp
71.64
10
10944329 (1), 7798313 (1), 8521955 (1), 10562278 (1) (see all 9 )
gtp
66.02
13
10455022 (2), 7798313 (1), 8521955 (1), 8223626 (1) (see all 9 )
lipid
24.14
8
16473585 (1), 17048274 (1), 16401880 (1), 18939858 (1) (see all 7 )
phosphotyrosine
8.29
1
14680817 (1)
phenylalanine
4.84
1
15339665 (1)
calcium
3.48
1
17010659 (1)
phosphoinositide
0.00
1
12952078 (1)
cholesterol
0.00
2
16473585 (1), 17135363 (1)
zinc
0.00
1
11258916 (1)
tyrosine
0.00
1
16473587 (1)
About this table
Transcripts for RAB6A(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_002869 Browse siRNA at Sigma-Aldrich Sigma-Aldrich shRNA for RAB6A Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_002869 NM_198896
REFSEQ mRNAs for RAB6A gene (2 alternative transcripts): NM_002869.4 NM_198896.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002869 NM_198896
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_002869                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_002869                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_002869  
Additional cDNA sequence: AB073348.1 AF091031.1 AF166492.1 AF498940.1 AK055102.1 AK295451.1 AK312378.1 AL713646.1 BC002510.2 BC036864.1 BC063556.1 BC078662.1 BT007263.1 U66623.1
24/40 DOTS entries (see all 40
): DT.92017399 DT.95358187 DT.97763740 DT.113719 DT.100823623 DT.116564 DT.113720 DT.120744709 DT.97859628 DT.100823625 DT.100037851 DT.87016146 DT.120744771 DT.120744755 DT.120744783 DT.405519 DT.70102087 DT.40121228 DT.453089 DT.100753641 DT.102832487 DT.120744787 DT.100771764 DT.100823624
24/567 AceView cDNA sequences (see all 567
):AF130986 CR625610 AI801986 CA313851 BF440048 AA465710 N70212 AA960808 AF498941 BQ934461 F03665 AA496089 AA535363 BM974412 AI239555 BU161628 N25676 AA431581 AI133531 AA988575 AW467920 Z41006 AI435940 AA169748
highest scoring ESTs for RAB6A :M28212 AA171433 AA370322 AA535363 AA570137 AA806163 AA813188 AA934745 AA993035 AI277186
Unigene Clusters for RAB6A: RAB6A, member RAS oncogene family Hs.503222 [show with all ESTs ] , Hs.535586 [show with all ESTs ] , Hs.591552 [show with all ESTs ] , Hs.707804 [show with all ESTs ] Unigene Representative Sequences: NM_002869 , DQ786271 , AL136727 , NM_016577 GeneLoc Exon Structure 3 Ensembl transcripts including schematic representations : ENST00000393571
ENST00000336083
ENST00000310653
Expression for RAB6A
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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RAB6A expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for RAB6A 1 / 2 / 3
12 probe-sets matching RAB6A gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene clusters: Hs.503222 Hs.535586 Hs.591552 Hs.707804 Expression variation in blood from EXPOLDB for RAB6A
UniProtKB/Swiss-Prot: RAB6A_HUMAN, P20340 Tissue specificity : Ubiquitous
Orthologs for RAB6A
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for RAB6A gene from 5/19 species (see all 19
)
About this table Species with no ortholog for RAB6A ENSEMBL Gene Tree for RAB6A Paralogs for RAB6A (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for RAB6A gene RAB20 2 RAB21 2 RAB6C 2 RAB41 2 RAB6B 2
SNPs/Variants for RAB6A (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for RAB6A (up to first 250kb)
Disorders & Mutations for RAB6A
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 179513 4 Novoseek disease relationships for RAB6A gene
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Medical News for RAB6A (Possibly Related Articles in
Doctor's Guide )
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--
Publications for RAB6A (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/180 PubMed articles for RAB6A gene (see all 180
): Characterization of the human GARP (Golgi associated retrograde protein) complex. (PubMed id 15878329) 3, 4 Liewen H.... Stenner-Liewen F. (2005) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex. (PubMed id 12447383) 3, 4 Matanis T.... Hoogenraad C.C. (2002) Rab6c, a new member of the Rab gene family, is involved in drug resistance in MCF7/AdrR cells. (PubMed id 11054569) 3, 4 Shan J.... Xu H.-P. (2000) Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells. (PubMed id 10996854) 3, 4 Caillol N.... Lombardo D. (2000) Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms. (PubMed id 11071909) 3, 4 Echard A.... Fransen J.A.M. (2000) Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome. (PubMed id 10202141) 3, 4 Cuif M.-H....Goud B. (1999) The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. (PubMed id 2501306) 3, 4 Zahraoui A.... Tavitian A. (1989) Transport of ricin from endosomes to the Golgi apparatus is regulated by Rab6A and Rab6A'. (PubMed id 16683916) 1, 3 Utskarpen A....Sandvig K. (2006)
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Genome Databases showing RAB6A
(According to
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euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
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Specialized Databases showing RAB6A (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for RAB6A (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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