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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB6A Gene

protein-coding   GIFtS: 63
GCID: GC11M073386

RAB6A, Member RAS Oncogene Family


(Previous symbol: RAB6)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAB6A, Member RAS Oncogene Family1 2
RAB61 2 3 5
Rab GTPase2
RAB6, Member RAS Oncogene Family2
Ras-Related Protein Rab-6A2
Rab-63

External Ids:    HGNC: 97861   Entrez Gene: 58702   Ensembl: ENSG000001755827   OMIM: 1795135   UniProtKB: P203403   

Export aliases for RAB6A gene to outside databases

Previous GC identifers: GC11M075714 GC11M074926 GC11M073609 GC11M073113 GC11M073112 GC11M073064 GC11M069682


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAB6A Gene:
This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB
family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor
compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde
(from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma
membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved
in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts
with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding
different isoforms have been identified. (provided by RefSeq, Aug 2011)

GeneCards Summary for RAB6A Gene: 
RAB6A (RAB6A, member RAS oncogene family) is a protein-coding gene. Diseases associated with RAB6A include oculocerebrorenal syndrome, and choroideremia, and among its related super-pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and protein domain specific binding. An important paralog of this gene is RAB6C.

UniProtKB/Swiss-Prot: RAB6A_HUMAN, P20340
Function: Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic
reticulum (ER). Has a low GTPase activity

Gene Wiki entry for RAB6A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB6A gene promoter:
         Bach1   NF-1   NF-1/L   Sp1   Olf-1   FOXO4   HFH-1   IRF-7A   Pax-4a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAB6A promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB6A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB6A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.3   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.3

RAB6A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB6A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M073386:  view genomic region     (about GC identifiers)

Start:
73,386,683 bp from pter      End:
73,472,201 bp from pter
Size:
85,519 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RAB6A_HUMAN, P20340 (See protein sequence)
Recommended Name: Ras-related protein Rab-6A  
Size: 208 amino acids; 23593 Da
Subunit: Interacts with CCDC64; leads to its accumulation in the pericentrosomal region (By similarity). Interacts
with SCYL1BP1. Interacts with VSP52 and RABGAP1. Interacts with GCC2 (via its GRIP domain). Interacts with
RAB6IP1 (via its RUN 1 domain). Isoform 1 interacts with RAB6KIFL. Isoform 2 does not interact with RAB6KIFL.
Isoform 1 interacts with BICD1. Isoform 2 interacts with BICD1. Isoform 1 interacts with BICD2. Isoform 2
interacts with BICD2. Interacts with TMF1. Isoform 1 (GTP-bound) interacts with DYNLRB1; the interaction is
direct. Isoform 2 (GDP-bound) interacts with DYNLRB1; the interaction is direct. Interacts with PIFO
Subcellular location: Golgi apparatus membrane; Lipid-anchor
5 PDB 3D structures from and Proteopedia for RAB6A:
1YZQ (3D)        2GIL (3D)        3BBP (3D)        3CWZ (3D)        4DKX (3D)    
Secondary accessions: A8K133 B7Z772 F5H668 Q1W5D8 Q5U0A8 Q9UBE4
Alternative splicing: 4 isoforms:  P20340-1   P20340-2   P20340-3   P20340-4   

Explore the universe of human proteins at neXtProt for RAB6A: NX_P20340

Explore proteomics data for RAB6A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P20340

  • RAB6A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAB6A Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001230647.1  NP_001230648.1  NP_002860.2  NP_942599.1  

    ENSEMBL proteins: 
     ENSP00000311449   ENSP00000336850   ENSP00000443782   ENSP00000445350   ENSP00000440469  
     ENSP00000438842   ENSP00000443470   ENSP00000383318   ENSP00000437863  

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    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus IDA11121396

    RAB6A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P20340

    ProtoNet protein and cluster: P20340

    1 Blocks protein domain: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RAB6A_HUMAN, P20340
    Similarity: Belongs to the small GTPase superfamily. Rab family


    RAB6A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAB6A_HUMAN, P20340
    Function: Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic
    reticulum (ER). Has a low GTPase activity

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA16332443
    GO:0005515protein binding IPI12391317
    GO:0005525GTP binding IDA16332443
    GO:0019904protein domain specific binding IPI12447383
         
    RAB6A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RAB6A:
     Decreased p24 protein expressi  Proliferating cells 

    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAB6A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    2Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB6A
        Epithelial Tight Junctions

    1 Cell Signaling Technology (CST) Pathway for RAB6A
        Cytoskeletal Signaling




    RAB6A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB6A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/308 Interacting proteins for RAB6A (P203401, 2, 3 ENSP000003114494) via UniProtKB, MINT, STRING, and/or I2D (see all 308)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000042protein targeting to Golgi IDA18243103
    GO:0006184GTP catabolic process TAS2501306
    GO:0006886intracellular protein transport ----
    GO:0006890retrograde vesicle-mediated transport, Golgi to ER TAS12447383
    GO:0006913nucleocytoplasmic transport ----

    RAB6A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RAB6A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAB6A

    10/16 Novoseek inferred chemical compound relationships for RAB6A gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 71.8 11 10944329 (1), 7798313 (1), 8521955 (1), 10562278 (1) (see all 10)
    gtp 66.1 13 10455022 (2), 7798313 (1), 8521955 (1), 8223626 (1) (see all 9)
    n-ethylmaleimide 30.4 1 14872244 (1)
    cysteine 29.6 2 11258916 (1), 9607139 (1)
    lipid 21 8 16473585 (1), 17048274 (1), 16401880 (1), 18939858 (1) (see all 7)
    phosphoinositide 7.62 1 12952078 (1)
    phosphotyrosine 6.21 1 14680817 (1)
    calcium 5.42 2 17010659 (1), 20001421 (1)
    phosphatidylinositol 4.45 5 17651088 (2), 12640132 (1), 18843044 (1), 20231409 (1)
    phenylalanine 2.43 1 15339665 (1)

    Search CenterWatch for drugs/clinical trials and news about RAB6A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAB6A gene (4 alternative transcripts): 
    NM_001243718.1  NM_001243719.1  NM_002869.4  NM_198896.1  

    Unigene Clusters for RAB6A:

    RAB6A, member RAS oncogene family
    Hs.503222  [show with all ESTs], Hs.591552  [show with all ESTs]
    Unigene Representative Sequences: NM_002869, AL136727
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310653(uc021qnd.1 uc001oue.3 uc009yts.3) ENST00000336083(uc001ouf.3)
    ENST00000541973 ENST00000541588 ENST00000545625 ENST00000540771 ENST00000537446
    ENST00000400470 ENST00000541795(uc001oug.3) ENST00000536566

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    Additional mRNA sequence: 

    AF091030.1 AF309646.1 AK055504.1 AL136727.1 BC120998.2 BC120999.1 CR533469.1 

    24/28 DOTS entries (see all 28):

    DT.92017399  DT.95358187  DT.100823623  DT.120744709  DT.97859628  DT.100823625  DT.100037851  DT.120744771 
    DT.120744755  DT.120744783  DT.405519  DT.40121228  DT.453089  DT.102832487  DT.120744787  DT.100753641 
    DT.100771764  DT.70102087  DT.100823624  DT.91864076  DT.91896502  DT.120744711  DT.120744733  DT.91796649 

    24/567 AceView cDNA sequences (see all 567):

    CB250598 AW467920 AF130986 CA313851 BM974412 AL709962 BQ934461 AA431581 
    H39193 AA465710 AI133531 CB162686 AL602652 T08767 NM_198896 R13274 
    BX503198 AF119836 BQ129978 AI435940 BQ718935 BC003617 BQ422263 N25676 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB6A expression in normal human tissues (normalized intensities)      RAB6A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTGAAATA
    RAB6A Expression
    About this image


    RAB6A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Hippocampus
             postcentral gyrus   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; endothelial cells   
     
     Epithelium (Reproductive System)    fully expand to see all 4 entries
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   

    See RAB6A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAB6A

    SOURCE GeneReport for Unigene clusters: Hs.503222 Hs.591552

    UniProtKB/Swiss-Prot: RAB6A_HUMAN, P20340
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including RAB6A: 
              Huntington's Disease in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAB6A gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab6a1 , 5 RAB6A, member RAS oncogene family1, 5 90.71(n)1
    97.6(a)1
      7 (54.36 cM)5
    193461  NM_024287.41  NP_077249.11 
     1006074105 
    chicken
    (Gallus gallus)
    Aves RAB6A1 RAB6A, member RAS oncogene family 89.58(n)
    99.04(a)
      419063  NM_001044640.1  NP_001038105.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    99(a)
    90(a)
    possible ortholog
    possible ortholog
    GL343983.1(92334-113993)
    AAWZ02038411(231-10643)
    African clawed frog
    (Xenopus laevis)
    Amphibia rab6-prov2 RAB6A, member RAS oncogene family 86.23(n)    BC046683.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.286072 Transcribed sequence with moderate similarity to protein more 77.67(n)    CK354911.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rab61 , 3 RAB small monomeric GTPase3
    Rab-protein 61
    85(a)3
    69.74(n)1
    86.41(a)1
      33C43
    346361  NM_057824.41  NP_477172.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C56E6.23
    rab-6.21
    GTP-binding3
    Protein RAB-6.21
    38(a)3
    68.47(n)1
    79.8(a)1
      II(6524883-6525953)3
    1817591  NM_078389.21  NP_510790.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YPT66
    Rab family GTPase, Ras-like GTP binding protein in...
    60(a)
    1 → many
    XII(668244-668891)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RAB6A1 Ras-related protein RABH1B 68.69(n)
    75.76(a)
      819069  NM_130025.4  NP_181989.1 
    rice
    (Oryza sativa)
    Liliopsida Os.60322 Oryza sativa (japonica cultivar-group) putative ras-related more 74.41(n)    NM_187359.1 


    ENSEMBL Gene Tree for RAB6A (if available)
    TreeFam Gene Tree for RAB6A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAB6A gene
    RAB6C2  RAB412  RAB362  RAB342  RAB6B2  
    18/102 SIMAP similar genes for RAB6A using alignment to 6 protein entries:     RAB6A_HUMAN (see all proteins) (see all similar genes):
    RAB6A'    RAB6B    RAB6C    RAB41    DKFZp313C1541    RAB2B
    RAB5C    RAB5B    RAB8B    RAB13    RAB2A    RAB39B
    RAB3A    RAB11A    RAB5A    RAB37    RAB8A    RAB31

    RAB6A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1921 SNPs in RAB6A are shown (see all 1921)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1165791001,2
    C,F--73250425(+) ATAGTA/TAACAG 4 -- ds50011Minor allele frequency- T:0.02WA 118
    rs735386261,2
    C,F--73250836(+) AAATGC/TTAATT 4 -- ds50012Minor allele frequency- T:0.04WA 120
    rs1163515901,2
    C,F--73251130(+) GACCCA/TTCTGC 4 -- ut311Minor allele frequency- T:0.04WA 118
    rs1387349351,2
    C--73251253(+) ATCTT-/TAAGTA
            
    TAAGT
    4 -- cds10--------
    rs42011,2
    C--73251258(+) ATCTT-/ATAAG 
    T
    /TAAGTA
    TAAGT
    12 -- ut315EU NA EA 344
    rs1420571431,2
    --73251275(+) TATGTA/GGGCTA 4 -- ut310--------
    rs1869741571,2
    --73251552(+) CAAACA/TATGTA 4 -- ut310--------
    rs1914413541,2
    --73251606(+) CTAGTA/GAAGAT 4 -- ut310--------
    rs2016333571,2
    --73251803(+) ACCAG-/TTAA  
            
    TTAAA
    4 -- ut310--------
    rs1513355811,2
    --73251899(+) AATATA/TGAGTT 4 -- ut310--------

    HapMap Linkage Disequilibrium report for RAB6A (73386683 - 73472201 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for RAB6A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2744772CNV Deletion23290073
    esv2665533CNV Deletion23128226
    nsv897912CNV Loss21882294
    nsv510260CNV Loss20534489
    esv22024CNV Loss19812545
    esv25152CNV Loss19812545
    nsv390CNV Loss18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 179513    OMIM disorders: --

    19 diseases for RAB6A:    About MalaCards
    oculocerebrorenal syndrome    choroideremia    legionnaires' disease    hemophagocytic lymphohistiocytosis
    retinal degeneration    vaccinia    influenza    retinitis
    choroiditis    huntington's disease    acute lymphoblastic leukemia    insulin resistance
    lymphoblastic leukemia    myeloma    alzheimer's disease    leukemia
    melanoma    pancreatitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for RAB6A:
    Oculocerebrorenal syndrome

    RAB6A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for RAB6A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinal degeneration 33.4 1 9685396 (1)
    cancer 1.89 3 19425190 (1), 19620778 (1), 15805241 (1)
    tumors 0.356 1 15337753 (1)
    influenza 0 2 7798313 (1)

    Genetic Association Database (GAD): RAB6A
    Human Genome Epidemiology (HuGE) Navigator: RAB6A (1 document)

    Export disorders for RAB6A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB6A gene, integrated from 9 sources (see all 220):
    (articles sorted by number of sources associating them with RAB6A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rab and Arl GTPase family members cooperate in the localization of the golgin GCC185. (PubMed id 18243103)1, 2, 9 Burguete A.S....Pfeffer S.R. (2008)
    2. Rab6 family proteins interact with the dynein light chain protein DYNLRB1. (PubMed id 18044744)1, 2, 9 Wanschers B.F.J.... Fransen J. (2008)
    3. Structural basis for recruitment of Rab6-interacting protein 1 to Golgi via a RUN domain. (PubMed id 19141279)1, 2 Recacha R....Khan A.R. (2009)
    4. Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8A resolution. (PubMed id 16332443)1, 2 Bergbrede T.... Alexandrov K. (2005)
    5. Characterization of the human GARP (Golgi associated retrograde protein) complex. (PubMed id 15878329)1, 2 Liewen H.... Stenner-Liewen F. (2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex. (PubMed id 12447383)1, 2 Matanis T.... Hoogenraad C.C. (2002)
    9. Rab6c, a new member of the Rab gene family, is involved in drug resistance in MCF7/AdrR cells. (PubMed id 11054569)1, 2 Shan J.... Xu H.-P. (2000)
    10. Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells. (PubMed id 10996854)1, 2 Caillol N.... Lombardo D. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5870 HGNC: 9786 AceView: RAB6A Ensembl:ENSG00000175582 euGenes: HUgn5870
    ECgene: RAB6A H-InvDB: RAB6A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB6A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB6A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAB6A gene:
    Search GeneIP for patents involving RAB6A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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