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RAB6A Gene

protein-coding   GIFtS: 57

GC11M073064
RAB6A, member RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: RAB6)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
RAB6 2, 3, 5
RAB6A' 2
RAB6B 2
Rab-6 3
Descriptions
GTP-binding protein RAB6A' 2
GTP-binding protein RAB6B 2
Oncogene RAB6 2
RAB6, member RAS oncogene family 2
RAB6A, member RAS oncogene family 2
Rab GTPase 2
Rab6A variant 3 2
External Ids
HGNC: 97861
Entrez Gene: 58702
UniProtKB: P203403
Ensembl: ENSG000001755827
Search outside databases for aliases for RAB6A gene

Previous GC identifers: GC11M075714 GC11M074926 GC11M073609 GC11M073113 GC11M073112

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RAB6A_HUMAN, P20340
Function: Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the
endoplasmic reticulum (ER). Has a low GTPase activity

Gene Wiki entry for RAB6A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RAB6A gene  

Entrez Gene cytogenetic band: 11q13.3   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.3

RAB6A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M073064:     (about GC identifiers)

Start:
73,064,331 bp from pter
End:
73,149,849 bp from pter
Size:
85,519 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000011.8  NT_033927.7  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RAB6A_HUMAN, P20340 (See protein sequence)
Recommended Name: Ras-related protein Rab-6A  
Size: 208 amino acids; 23593 Da
Subunit: Interacts with SCYL1BP1. Interacts with VSP52 and RABGAP1. Isoform 1 interacts with
RAB6KIFL but not isoform 2. Isoforms 1 and 2 interact with BICD1 and BICD2. Interacts with TMF1
Subcellular location: Golgi apparatus membrane; Lipid-anchor
PDB structures from and Proteopedia :
1YZQ (3D)    2GIL (3D)    3BBP (3D)    3CWZ (3D)    
Secondary accessions: A8K133 Q5U0A8 Q9UBE4
Alternative splicing: 2 isoforms:  P20340-1   P20340-2   

Post-translational modifications:

  • Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity)1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_002860.2  NP_942599.1  


    ENSEMBL proteins: 
    ENSP00000377201 ENSP00000336850 ENSP00000311449 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (RAB6A)
                   OriGene Purified Recombinant Human Proteins (see all 2): RAB6A  

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139 Golgi membrane IEA--
    GO:0005794 Golgi apparatus IDA15229288
    GO:0016020 membrane IEA--
    About this table

    Antibodies for RAB6A: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for RAB6A
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Monoclonal and Polyclonal Antibodies from Abnova (RAB6A)
    Novus Biologicals Antibody for RAB6A

    Assays for RAB6A: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5 InterPro domains/families:
     IPR015600 Rab6-like
     IPR001806 Ras_GTPase
     IPR005225 Small_GTP_bd
     IPR003579 GTPase_Rab
     IPR013753 Ras


       GeneDecks  RAB6A for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P20340

    ProtoNet protein and cluster: P20340

    1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RAB6A_HUMAN, P20340
    Similarity: Belongs to the small GTPase superfamily. Rab family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB6A)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (RAB6A)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002869

                  Applied Biosystems Silencer® siRNAs for RAB6A

                  Browse siRNA at Sigma-Aldrich  
                         Sigma-Aldrich shRNA for RAB6A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002869
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002869
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_002869 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_198896

    UniProtKB/Swiss-Prot: RAB6A_HUMAN, P20340
    Function: Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the
    endoplasmic reticulum (ER). Has a low GTPase activity

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003924 GTPase activity TAS2501306
    GO:0005515 protein binding IPI12391317
    GO:0005525 GTP binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  RAB6A 


    5/25 Interacting proteins for RAB6A (ENSP000003368503 P203401, 2) via UniProtKB, MINT, and/or STRING (see all 25 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DCTN1Q142032STRING (score=.997) MINT-2883031
    GCC2Q8IWJ2-21STRING (score=.998) EBI-1052826, EBI-1645335
    PMM1Q928712MINT-66921
    BICD1ENSP000002814743STRING (score=.985)
    KIF20AENSP000002309023STRING (score=.964)
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264 small GTPase mediated signal transduction IEA--
    GO:0015031 protein transport IEA--
    GO:0016192 vesicle-mediated transport IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for RAB6A
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for RAB6A
    10/11 Novoseek chemical compound relationships for RAB6A gene (see all 11 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 71.64 10 10944329 (1), 7798313 (1), 8521955 (1), 10562278 (1) (see all 9)
    gtp 66.02 13 10455022 (2), 7798313 (1), 8521955 (1), 8223626 (1) (see all 9)
    lipid 24.14 8 16473585 (1), 17048274 (1), 16401880 (1), 18939858 (1) (see all 7)
    phosphotyrosine 8.29 1 14680817 (1)
    phenylalanine 4.84 1 15339665 (1)
    calcium 3.48 1 17010659 (1)
    phosphoinositide 0.00 1 12952078 (1)
    cholesterol 0.00 2 16473585 (1), 17135363 (1)
    zinc 0.00 1 11258916 (1)
    tyrosine 0.00 1 16473587 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB6A)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (RAB6A)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002869

                  Browse siRNA at Sigma-Aldrich  
                         Sigma-Aldrich shRNA for RAB6A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_002869  NM_198896  

    REFSEQ mRNAs for RAB6A gene (2 alternative transcripts): 

    NM_002869.4   NM_198896.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_002869  NM_198896  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002869
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002869
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_002869 

    Additional cDNA sequence: 

    AB073348.1 AF091031.1 AF166492.1 AF498940.1 AK055102.1 AK295451.1 AK312378.1 AL713646.1 
    BC002510.2 BC036864.1 BC063556.1 BC078662.1 BT007263.1 U66623.1 

    24/40 DOTS entries (see all 40 ):

    DT.92017399  DT.95358187  DT.97763740  DT.113719  DT.100823623  DT.116564  DT.113720  DT.120744709 
    DT.97859628  DT.100823625  DT.100037851  DT.87016146  DT.120744771  DT.120744755  DT.120744783  DT.405519 
    DT.70102087  DT.40121228  DT.453089  DT.100753641  DT.102832487  DT.120744787  DT.100771764  DT.100823624 

    24/567 AceView cDNA sequences (see all 567 ):

    AF130986 CR625610 AI801986 CA313851 BF440048 AA465710 N70212 AA960808 
    AF498941 BQ934461 F03665 AA496089 AA535363 BM974412 AI239555 BU161628 
    N25676 AA431581 AI133531 AA988575 AW467920 Z41006 AI435940 AA169748 

    highest scoring ESTs for RAB6A:

    M28212 AA171433 AA370322 AA535363 AA570137 AA806163 AA813188 AA934745 AA993035 AI277186 

    Unigene Clusters for RAB6A:

    RAB6A, member RAS oncogene family
    Hs.503222  [show with all ESTs], Hs.535586  [show with all ESTs], Hs.591552  [show with all ESTs], Hs.707804  [show with all ESTs]
    Unigene Representative Sequences: NM_002869, DQ786271, AL136727, NM_016577


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations:
    ENST00000393571  ENST00000336083  ENST00000310653  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    RAB6A expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for RAB6A

    1 / 2 / 3

    12 probe-sets matching RAB6A gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    35304_at2, 3 U95-A 4 1.00 0.62 0.88 0.98 M28212 1.00 0.90 0.95 1
    622_at2, 3 U95-A 5 1.00 0.55 0.85 0.74 M28212 1.00 0.90 0.95 1

    74773_s_at2, 3 U95-D 4 1.00 0.44 0.80 1.28 AW014361 0.80 0.88 0.84 1

    201045_s_at2, 3 U133-A 2 1.00 0.91 -- -- BF513857 0.80 1.00 0.91 1

    201048_x_at2, 3 U133-A 5 1.00 0.78 -- -- NM_002869 0.60 1.00 0.82 1

    201047_x_at2, 3 U133-A 4 1.00 0.28 -- -- BC003617 0.80 0.88 0.84 1

    210406_s_at2, 3 U133-A 4 1.00 0.27 -- -- AL136727 0.20 0.33 0.27 2

    1559174_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    201045_s_at2 U133Plus2 2 1.00 0.91 -- -- -- -- -- -- --

    201048_x_at2 U133Plus2 5 1.00 0.78 -- -- -- -- -- -- --

    201047_x_at2 U133Plus2 4 1.00 0.28 -- -- -- -- -- -- --

    210406_s_at2 U133Plus2 4 1.00 0.27 -- -- -- -- -- -- --
    GeneDecks  RAB6A for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene clusters: Hs.503222 Hs.535586 Hs.591552 Hs.707804

    Expression variation in blood from EXPOLDB for RAB6A

    UniProtKB/Swiss-Prot: RAB6A_HUMAN, P20340
    Tissue specificity: Ubiquitous

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for RAB6A gene from 5/19 species (see all 19 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    RAB6A1   -- RAB6A, member RAS oncogene family 93.43(n)
    98.56(a)
    608330  XM_845178.1  XP_850271.1 
    cow
    (Bos taurus)
    RAB6A1   -- RAB6A, member RAS oncogene family 91.67(n)
    98.08(a)
    616537  XM_001252029.1  XP_001252030.1 
    rat
    (Rattus norvegicus)
    Rab6a1   -- RAB6A, member RAS oncogene family 95.19(n)
    99.04(a)
    84379  XM_001062702.1  XP_001062702.1 
    mouse
    (Mus musculus)
    Rab61, 5 75
    RAB6, member RAS oncogene family1, 5 90.71(n)1
    97.6(a)1
    193461  NM_024287.31  NP_077249.11 
     AA4196715  AB0415755  (see all 28)
    chicken
    (Gallus gallus)
    RAB6A1   -- RAB6A, member RAS oncogene family 89.58(n)
    99.04(a)
    419063  NM_001044640.1  NP_001038105.1 
    About this table        Species with no ortholog for RAB6A

    ENSEMBL Gene Tree for RAB6A
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for RAB6A gene
    RAB202  RAB212  RAB6C2  RAB412  RAB6B2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/635 NCBI SNPs in RAB6A are shown (see all 635 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 76)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs17238401,2
    A,C,F,H73151533(+) TGTACT/ATTTTC 2 -- ng3110Minor allele frequency- A:0.22EU EA WA NA 1014
    --
    rs108989321,2
    A,C,F,H73066237(-) GAGCGG/CTATGT 2 -- ut31 ese37Minor allele frequency- C:0.33NA EU EA WA 554
    --
    rs10432341,2
    C,F,H73149409(-) CGCTCG/TCCTTT 2 -- ut51 ese33Minor allele frequency- T:0.12EA MN EU 1802
    --
    rs112358511,2
    A,C,F73066147(+) AAGTCG/AGGGGA 2 -- ut31 ese31Minor allele frequency- A:0.12EA 172
    --
    rs108989311,2
    C,F,H73066011(+) AATTTA/TTATCA 2 -- ut3112Minor allele frequency- T:0.40EA NA EU WA 1050
    --
    rs31827501,2
    C,H73107361(-) AGCTTG/CATTCC 2 F/L mis1 int1 ese39Minor allele frequency- C:0.01MN EU EA WA 1016
    --
    rs65925331,2
    A,C73149782(+) TCTGGA/CGCGGC 2 -- ut51 ese30--------
    --
    rs23669401,2
    A,C73151430(-) tttttG/Tttttt 2 -- ng310--------
    --
    rs17238411,2
    A73151421(-) TTTTTG/TTTTTT 2 -- ng31 trp30--------
    --
    rs42011,2
    F73064706(+) ATCTTTAAGTA/-
            
    TAAGT
    2 -- ut314Minor allele frequency- -:0.16EU NA EA 342
    About this table

    HapMap Linkage Disequilibrium images for RAB6A (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 179513

    4 Novoseek disease relationships for RAB6A gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinal degeneration 36.10 1 9685396 (1)
    cancer 1.02 2 19425190 (1), 15805241 (1)
    tumors 0.39 1 15337753 (1)
    influenza 0.00 2 7798313 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/180 PubMed articles for RAB6A gene (see all 180 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 5870 HGNC: 9786 AceView: RAB6A Ensembl:ENSG00000175582 euGenes: HUgn5870
    ECgene: RAB6A H-InvDB: RAB6A
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for RAB6A Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for RAB6A:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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