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Aliases for RAB5C Gene

Aliases for RAB5C Gene

  • RAB5C, Member RAS Oncogene Family 2 3
  • RABL 3 4 6
  • L1880 3 4
  • RAB5L 3 4
  • RAB5C, Member Of RAS Oncogene Family 3
  • Member Of RAS Oncogene Family-Like 2
  • Member Of RAS Oncogene Family 2
  • Ras-Related Protein Rab-5C 3
  • RAB5CL 3
  • RAB5C 2
  • RAB 2

External Ids for RAB5C Gene

Previous Symbols for RAB5C Gene

  • RABL

Summaries for RAB5C Gene

Entrez Gene Summary for RAB5C Gene

  • Members of the Rab protein family are small GTPases of the Ras superfamily that are thought to ensure fidelity in the process of docking and/or fusion of vesicles with their correct acceptor compartment (Han et al., 1996 [PubMed 8646882]).[supplied by OMIM, Nov 2010]

GeneCards Summary for RAB5C Gene

RAB5C (RAB5C, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Endocytosis. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB17.

UniProtKB/Swiss-Prot for RAB5C Gene

  • Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Wiki entry for RAB5C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB5C Gene

Genomics for RAB5C Gene

Genomic Location for RAB5C Gene

Start:
42,124,976 bp from pter
End:
42,155,044 bp from pter
Size:
30,069 bases
Orientation:
Minus strand

Genomic View for RAB5C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB5C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB5C Gene

Regulatory Elements for RAB5C Gene

Proteins for RAB5C Gene

  • Protein details for RAB5C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51148-RAB5C_HUMAN
    Recommended name:
    Ras-related protein Rab-5C
    Protein Accession:
    P51148
    Secondary Accessions:
    • F8W1H5
    • Q6FH55
    • Q9P0Y5

    Protein attributes for RAB5C Gene

    Size:
    216 amino acids
    Molecular mass:
    23483 Da
    Quaternary structure:
    • Binds EEA1

    Three dimensional structures from OCA and Proteopedia for RAB5C Gene

    Alternative splice isoforms for RAB5C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB5C Gene

Proteomics data for RAB5C Gene at MOPED

Post-translational modifications for RAB5C Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys117 and Lys135

Other Protein References for RAB5C Gene

No data available for DME Specific Peptides for RAB5C Gene

Domains for RAB5C Gene

Gene Families for RAB5C Gene

HGNC:
  • RAB :RAB, member RAS oncogene

UniProtKB/Swiss-Prot:

RAB5C_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rab family.:
    • P51148
genes like me logo Genes that share domains with RAB5C: view

Function for RAB5C Gene

Molecular function for RAB5C Gene

GENATLAS Biochemistry: RAB5C,Ras oncogene superfamily member,involved in endocytosis
UniProtKB/Swiss-Prot Function: Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Ontology (GO) - Molecular Function for RAB5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 17562788
GO:0005515 protein binding IPI 17562788
GO:0005525 GTP binding IEA --
GO:0019003 GDP binding IDA 20937701
genes like me logo Genes that share ontologies with RAB5C: view
genes like me logo Genes that share phenotypes with RAB5C: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB5C Gene

Localization for RAB5C Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB5C Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB5C Gene COMPARTMENTS Subcellular localization image for RAB5C gene
Compartment Confidence
endosome 5
plasma membrane 5
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RAB5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005765 lysosomal membrane IDA 17897319
GO:0005768 endosome --
genes like me logo Genes that share ontologies with RAB5C: view

Pathways for RAB5C Gene

genes like me logo Genes that share pathways with RAB5C: view

Gene Ontology (GO) - Biological Process for RAB5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction --
genes like me logo Genes that share ontologies with RAB5C: view

Transcripts for RAB5C Gene

Unigene Clusters for RAB5C Gene

RAB5C, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB5C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - -
SP5: - - - - - - - - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP8: - - - -
SP9: -
SP10: - - - - - - -
SP11: - - - - - -
SP12: - - - - - - -
SP13: -

Relevant External Links for RAB5C Gene

GeneLoc Exon Structure for
RAB5C
ECgene alternative splicing isoforms for
RAB5C

Expression for RAB5C Gene

mRNA expression in normal human tissues for RAB5C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB5C Gene

SOURCE GeneReport for Unigene cluster for RAB5C Gene Hs.650382

genes like me logo Genes that share expressions with RAB5C: view

Orthologs for RAB5C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB5C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB5C 36
  • 99.85 (n)
  • 100 (a)
RAB5C 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB5C 36
  • 95.06 (n)
  • 99.07 (a)
RAB5C 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB5C 36
  • 95.06 (n)
  • 98.61 (a)
RAB5C 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab5c 36
  • 91.51 (n)
  • 98.61 (a)
Rab5c 16
Rab5c 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB5C 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab5c 36
  • 92.9 (n)
  • 99.07 (a)
chicken
(Gallus gallus)
Aves RAB5C 36
  • 83.49 (n)
  • 94.44 (a)
RAB5C 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB5C 37
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia rab5-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rab5c 36
  • 79.94 (n)
  • 94.44 (a)
Str.10122 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.217 36
zebrafish
(Danio rerio)
Actinopterygii rab5c 36
  • 78.66 (n)
  • 91.12 (a)
rab5c 37
  • 88 (a)
OneToOne
wufj38g08 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007901 36
  • 73.52 (n)
  • 86.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab5 36
  • 66.97 (n)
  • 73.85 (a)
Rab5 37
  • 73 (a)
OneToMany
Rab5 38
  • 74 (a)
chrw 38
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea rab-5 37
  • 77 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS21 37
  • 53 (a)
ManyToMany
YPT52 39
YPT53 37
  • 45 (a)
ManyToMany
soybean
(Glycine max)
eudicotyledons Gma.6207 36
wheat
(Triticum aestivum)
Liliopsida Ta.222 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11163 37
  • 69 (a)
OneToMany
Species with no ortholog for RAB5C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RAB5C Gene

ENSEMBL:
Gene Tree for RAB5C (if available)
TreeFam:
Gene Tree for RAB5C (if available)

Paralogs for RAB5C Gene

Pseudogenes.org Pseudogenes for RAB5C Gene

genes like me logo Genes that share paralogs with RAB5C: view

Variants for RAB5C Gene

Sequence variations from dbSNP and Humsavar for RAB5C Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs10957 -- 42,125,162(-) GTCAC(A/C)CCAAC utr-variant-3-prime
rs15424 -- 42,125,064(-) CCAAC(C/T)TTTTC utr-variant-3-prime
rs731151 -- 42,127,885(-) TGCAA(C/T)ACTGC intron-variant
rs731152 -- 42,127,662(-) GAGGC(C/T)GAGGT intron-variant
rs739636 -- 42,129,045(+) GGGAC(G/T)CCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB5C Gene

Variant ID Type Subtype PubMed ID
nsv908241 CNV Loss 21882294
dgv3169n71 CNV Loss 21882294
esv1008006 CNV Insertion 20482838

Relevant External Links for RAB5C Gene

HapMap Linkage Disequilibrium report
RAB5C

Disorders for RAB5C Gene

No disorders were found for RAB5C Gene.

No data available for UniProtKB/Swiss-Prot for RAB5C Gene

Publications for RAB5C Gene

  1. Isolation and mapping of a human gene (RABL) encoding a small GTP- binding protein homologous to the Ras-related RAB gene. (PMID: 8646882) Han H.J. … Nakamura Y. (Cytogenet. Cell Genet. 1996) 2 3 4 23
  2. A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21. (PMID: 7951316) Albertsen H.M. … White R. (Nat. Genet. 1994) 3 4
  3. Determinants of Rab5 interaction with the N-terminus of early endosome antigen 1. (PMID: 12493736) Merithew E. … Lambright D.G. (J. Biol. Chem. 2003) 3 4
  4. Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fate. (PMID: 10768959) Clemens D.L. … Horwitz M.A. (Infect. Immun. 2000) 3 4
  5. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PMID: 17081065) Chi A. … Hunt D.F. (J. Proteome Res. 2006) 3 4

Products for RAB5C Gene

Sources for RAB5C Gene

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