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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB5C Gene

protein-coding   GIFtS: 59
GCID: GC17M040276

RAB5C, member RAS oncogene family


(Previous symbol: RABL)
 Explore 4 diseases affiliated with
RAB5C via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RAB5C    

Aliases
for RAB5C gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
RAB5C, Member RAS Oncogene Family1 2     RAB5L2 3
RABL1 2 3 5     RAB5C, Member Of RAS Oncogene Family2
RAB5CL1 2     Ras-Related Protein Rab-5C2
L18802 3     

External Ids:    HGNC: 97851   Entrez Gene: 58782   Ensembl: ENSG000001087747   OMIM: 6040375   UniProtKB: P511483   

Export aliases for RAB5C gene to outside databases

Previous GC identifers: GC17M039830 GC17M042432 GC17M040185 GC17M040650 GC17M037530 GC17M036043


Summaries
for RAB5C gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RAB5C:
Members of the Rab protein family are small GTPases of the Ras superfamily that are thought to ensure fidelity in the
process of docking and/or fusion of vesicles with their correct acceptor compartment (Han et al., 1996 (PubMed
8646882)).(supplied by OMIM, Nov 2010)

UniProtKB/Swiss-Prot: RAB5C_HUMAN, P51148
Function: Protein transport. Probably involved in vesicular traffic (By similarity)

Gene Wiki entry for RAB5C


Genomic Views
for RAB5C gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB5C gene promoter:
         SRF   NRSF form 1   SRF (504 AA)   HTF   NRSF form 2   E47   PPAR-gamma1   COUP-TF   Hand1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAB5C promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB5C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB5C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

RAB5C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB5C gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M040276:  view genomic region     (about GC identifiers)

Start:
 40,276,994 bp from pter      End:
 40,307,035 bp from pter
Size:
 30,042 bases      Orientation:
 minus strand

Proteins
for RAB5C gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RAB5C_HUMAN, P51148 (See protein sequence)
Recommended Name: Ras-related protein Rab-5C  
Size: 216 amino acids; 23483 Da
Subunit: Binds EEA1
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Early endosome membrane;
Lipid-anchor (By similarity). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to
stage IV
Secondary accessions: F8W1H5 Q6FH55 Q9P0Y5
Alternative splicing: 2 isoforms:  P51148-1   P51148-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAB5C: NX_P51148

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P51148

    • RAB5C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001238968.1  NP_004574.2  NP_958842.1  

    ENSEMBL proteins: 
     ENSP00000345689   ENSP00000447053   ENSP00000467144   ENSP00000449612   ENSP00000449777  
     ENSP00000448314   ENSP00000377440  
    Reactome Protein details: P51148
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: RAB5C
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    Novus Biologicals RAB5C Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RAB5C

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005811lipid particle IDA14741744
    GO:0005886plasma membrane IEA--
    GO:0030139endocytic vesicle IEA--
    GO:0031410cytoplasmic vesicle ----
    GO:0031901early endosome membrane IEA--


    RAB5C for ontologies           About GeneDecksing



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    Uscn Antibodies for RAB5C
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    Uscn ELISAs and CLIAs for RAB5C

    Protein Domains /
    Families
    for RAB5C gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RAB5C for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type

    Graphical View of Domain Structure for InterPro Entry P51148

    ProtoNet protein and cluster: P51148

    1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RAB5C_HUMAN, P51148
    Similarity: Belongs to the small GTPase superfamily. Rab family


    Function
    for RAB5C gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RAB5C_HUMAN, P51148
    Function: Protein transport. Probably involved in vesicular traffic (By similarity)

         Genatlas biochemistry entry for RAB5C:
    RAB5C,Ras oncogene superfamily member,involved in endocytosis

    miRNA
    Products:            		miRTarBase miRNAs that target RAB5C:
    hsa-mir-155 (MIRT001510)

    OriGene 3'-UTR Clone (see all 2): RAB5C
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAB5C
    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB5C (see all 51):
    hsa-miR-3164 hsa-miR-520e hsa-miR-302d hsa-miR-218-1* hsa-miR-765 hsa-let-7a-2* hsa-miR-486-3p hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmid: RAB5C 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB5C (see all 7)
    OriGene shRNA RFP: RAB5C
    OriGene siRNA: RAB5C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB5C

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RAB5C

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB5C (see all 4)
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    GenScript: all cDNA clones in your preferred vector (see all 2): RAB5C (NM_201434)
    Browse Sino Biological Human cDNA Clones
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    Cell Line
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    Search LifeMap BioReagents cell lines for RAB5C

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB5C

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS8646882
    GO:0005515protein binding ----
    GO:0005525GTP binding IEA--
    GO:0019003GDP binding IDA--


    RAB5C for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for RAB5C:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Rab5c):
     mortality/aging 

    RAB5C for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RAB5C gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Clathrin derived vesicle budding
    		Clathrin derived vesicle budding1.00
    		Golgi Associated Vesicle Biogenesis0.89
    		trans-Golgi Network Vesicle Budding1.00
    2Membrane Trafficking
    		Membrane Trafficking1.00
    3SMAD Signaling Network
    		SMAD Signaling Network1.00
    4Tuberculosis
    		Tuberculosis1.00
    5Amoebiasis
    		Amoebiasis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RAB5C
        SMAD Signaling Network
    Remodeling of Adherens Junctions
    Epithelial Tight Junctions

    4        Reactome Pathways for RAB5C
        Membrane Trafficking
    Clathrin derived vesicle budding
    Golgi Associated Vesicle Biogenesis
    trans-Golgi Network Vesicle Budding


    5         Kegg Pathways  (Kegg details for RAB5C):
        Endocytosis
    Phagosome
    Vasopressin-regulated water reabsorption
    Amoebiasis
    Tuberculosis


    RAB5C for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB5C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/27 Interacting proteins for RAB5C (P511483 ENSP000003456894) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OSGEPQ9NPF43, ENSP000002065424I2D: score=2 STRING: ENSP00000206542
    SUN2Q9UH993, ENSP000002160644I2D: score=2 STRING: ENSP00000216064
    PIK3C3Q8NEB93, ENSP000002620394I2D: score=1 STRING: ENSP00000262039
    RIN3Q8TB243, ENSP000002164874I2D: score=1 STRING: ENSP00000216487
    RAB5AP203393, ENSP000002730474I2D: score=1 STRING: ENSP00000273047
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS8646882
    GO:0007032endosome organization IEA--
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport IEA--
    GO:0030100regulation of endocytosis IEA--


    RAB5C for ontologies           About GeneDecksing



    Drugs & Compounds
    for RAB5C gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAB5C
    Search CenterWatch for drugs/clinical trials and news about RAB5C 

    Transcripts
    for RAB5C gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RAB5C gene (3 alternative transcripts): 
    NM_001252039.1  NM_004583.3  NM_201434.2  

    Unigene Cluster for RAB5C:

    RAB5C, member RAS oncogene family
    Hs.650382  [show with all ESTs]
    Unigene Representative Sequence: NM_001252039
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000346213(uc010cxx.3 uc002hza.3) ENST00000547517 ENST00000551338
    ENST00000552162 ENST00000546881 ENST00000550504 ENST00000550406 ENST00000550013
    ENST00000393860(uc002hyz.3)

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAB5C
    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB5C (see all 51):
    hsa-miR-3164 hsa-miR-520e hsa-miR-302d hsa-miR-218-1* hsa-miR-765 hsa-let-7a-2* hsa-miR-486-3p hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmid: RAB5C 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB5C (see all 7)
    OriGene shRNA RFP: RAB5C
    OriGene siRNA: RAB5C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB5C
    Clone
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    Primer
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    Additional cDNA sequence: 

    AF141304.1 AF498938.1 AK310234.1 BC106039.1 BC114439.1 BT019484.1 CR541901.1 U11293.1 
    U18420.1 

    21 DOTS entries:

    DT.218551  DT.100674027  DT.99937115  DT.91773125  DT.100059392  DT.97868410  DT.100674016  DT.120956965 
    DT.95255713  DT.120956924  DT.120956947  DT.91645886  DT.100048907  DT.100637732  DT.120956920  DT.120956963 
    DT.95086308  DT.97868408  DT.40240867  DT.92034962  DT.95255752 

    24/939 AceView cDNA sequences (see all 939):

    AA872135 CR625641 AI285811 BI088209 CR617757 BM705274 BG910375 BI770732 
    AU143628 BU556704 CR595680 CR625174 BM424202 AI272124 BM563618 CA396076 
    AI819556 BQ723274 BM791599 AI093720 BU181441 BX445994 BU622505 AW297019 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for RAB5C (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12
    SP1:              -     -     -     -     -     -     -                                               -     -                                       
    SP2:              -     -           -     -     -     -                                               -     -                                       
    SP3:              -     -     -     -     -     -     -                             -     -     -     -     -                                       
    SP4:                                                                                            -     -     -                                       
    SP5:              -     -     -     -     -     -     -           -     -     -     -     -     -     -     -     -     -                           


    ECgene alternative splicing isoforms for RAB5C

    Expression
    for RAB5C gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB5C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAACCAATCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See RAB5C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAB5C

    SOURCE GeneReport for Unigene cluster: Hs.650382
        SABiosciences Custom PCR Arrays for RAB5C
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    In Situ
    Assay Products:     
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    Orthologs
    for RAB5C gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAB5C gene from 8/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RAB5C1 RAB5C, member RAS oncogene family 83.49(n)
    94.44(a)    		   395197  NM_204525.1  NP_989856.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RAB5C6
    		 --
    		 93(a)
    		 1 → many
    		 6(72866784-72872789)
    African clawed frog
    (Xenopus laevis)    		 Amphibia rab5-prov2 Rab-protein 5 88.59(n)    BC056058.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufj38g082 Danio rerio cDNA clone MGC56009 IMAGE3819814, complete more 82.91(n)    BC047803.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Rab51 , 3 establishment and/or maintenance of
    chromatin more3
    Rab-protein 51    		 74(a)
    (best of 2)3
    68.11(n)1
    76.44(a)1    		   22E13
    334181  NM_078733.21  NP_523457.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea rab-56
    		 RAB family member (rab-5)
    		 78(a)
    		 1 → many
    		 I(9308429-9310213)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATRABF2A6
    ATRAB5B6
    (see all 3)    		 Ras-related small GTP-binding family protein
    (see all 3)    		 62(a)
    61(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 5(18244266-18246450)
    4(10687198-10689617)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 5)    		 ras-related protein, putative, expressed
    (see all 5)    		 63(a)
    53(a)
    (see all 5)    		 possible ortholog
    possible ortholog
    (see all 5)    		 3(26232232-26238782)
    3(2856121-2859228)


    ENSEMBL Gene Tree for RAB5C (if available)
    TreeFam Gene Tree for RAB5C (if available) 

    Paralogs
    for RAB5C gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAB5C gene
    RAB202  RAB312  ENSG000002672612  RAB5B2  RAB212  RAB5A2  RAB242  RAB22A2  
    RAB172  
    18/110 SIMAP similar genes for RAB5C using alignment to 5 protein entries:     RAB5C_HUMAN (see all proteins) (see all similar genes):
    RAB5B    RAB5A    rab1b    DKFZp686J06205    RAB22A    RAB11A
    RAB11B    RAB17    RAB4B    RAB6B    RAB21    RAB39B
    RAB6A    RAB24    RAB30    RAB41    DKFZp686J07132    RAB1C

    RAB5C for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RAB5C
    PGOHUM00000261087 PGOHUM00000261413


    Genomic Variants
    for RAB5C gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/524 NCBI SNPs in RAB5C are shown (see all 524)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1454983381,2
    		C,--40276505(+) GGTGT-/GGGGGG 3 -- int10--------
    rs1888012711,2
    		--40276507(+) GGTGTG/TGGGGG 3 -- int10--------
    rs129469781,2
    		C,F,H,--40276619(+) AGAGAG/AAGGAT 3 -- int17Minor allele frequency- A:0.04NS NA WA 1086
    rs1181856461,2
    		--40276637(+) CTCTCA/GCTGGT 3 -- int11Minor allele frequency- G:0.01NA 120
    rs358357021,2
    		C,--40276654(+) CAACC-/AAAAAA 3 -- int11Minor allele frequency- A:0.00NA 2
    rs2021713801,2
    		C--40276664(-) TCTTTG/TGGTTT 3 -- int10--------
    rs1393310131,2
    		--40276917(+) AGATTC/TAGTGG 3 -- int10--------
    rs1415903171,2
    		--40277039(+) CTGATC/TGGTTA 3 -- ut310--------
    rs1508236881,2
    		--40277110(+) CCCCCC/GCTTAC 3 -- ut310--------
    rs1928615661,2
    		--40277124(+) CCCACC/TCCCAA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for RAB5C (40276994 - 40307035 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RAB5C: --

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    Disorders / Diseases
    for RAB5C gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RAB5C for disorders           About GeneDecksing

    OMIM gene information: 604037    OMIM disorders: --

    4 diseases for RAB5C:    About MalaCards
    periodontitis    tuberculosis    malaria    mycobacterium tuberculosis


    Export disorders for RAB5C gene to outside databases

    Publications
    for RAB5C gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB5C gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with RAB5C)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and mapping of a human gene (RABL) encoding a small GTP- binding protein homologous to the Ras-related RAB gene. (PubMed id 8646882)1, 2, 3, 9 Han H.J.... Nakamura Y. (1996)
    2. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    3. Determinants of Rab5 interaction with the N-terminus of early endosome antigen 1. (PubMed id 12493736)1, 2 Merithew E.... Lambright D.G. (2003)
    4. Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fate. (PubMed id 10768959)1, 2 Clemens D.L.... Horwitz M.A. (2000)
    5. A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21. (PubMed id 7951316)1, 2 Albertsen H.M....White R. (1994)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Rab5c promotes AMAP1-PRKD2 complex formation to enhanc e b1 integrin recycling in EGF-induced cancer invasion. (PubMed id 22734003)1 Onodera Y....Sabe H. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for RAB5C gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RAB5C gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5878 HGNC: 9785 AceView: RAB5CandGCN5L2 Ensembl:ENSG00000108774 euGenes: HUgn5878
    ECgene: RAB5C Kegg: 5878 H-InvDB: RAB5C

    Other Databases showing RAB5C gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RAB5C gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB5C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB5C Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RAB5C gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RAB5C gene:
    Search GeneIP for patents involving RAB5C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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