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Aliases & Descriptions for RAB5C
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases L1880 3 MGC117217 2 MGC138857 2 RAB5CL 1 , 2 RAB5L 3 RABL 2 , 3 , 5
Descriptions RAB, member of RAS oncogene family-like 2 RAB5C, member RAS oncogene family 2 RAB5C, member of RAS oncogene family 2
Search outside databases for aliases for RAB5C genePrevious GC identifers: GC17M039830 GC17M042432 GC17M040185 GC17M040650
Summaries for RAB5C (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: RAB5C_HUMAN, P51148 Function : Protein transport. Probably involved in vesicular traffic (By similarity)
Gene Wiki entry for RAB5C
Genomic Location for RAB5C
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the RAB5C gene Entrez Gene cytogenetic band: 17q21.2 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q21.2 RAB5C Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17M037530:
(about GC identifiers )
Start:
37,530,523 bp from pter
End:
37,560,548 bp from pter
Size:
30,026 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000017.9 NT_010755.15 Proteins for RAB5C
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: RAB5C_HUMAN, P51148 (See
protein sequence )Recommended Name: Ras-related protein Rab-5C Size : 216 amino acids; 23483 Da
Subunit : Binds EEA1
Subcellular location : Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Early endosomemembrane; Lipid-anchor (By similarity). Melanosome. Note=Identified by mass spectrometry inmelanosome fractions from stage I to stage IV
Secondary accessions : Q6FH55 Q9P0Y5
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_004574.2 NP_958842.1 ENSEMBL proteins: ENSP00000345689 ENSP00000377440 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7
):
About this table Antibodies for RAB5C: Assays for RAB5C:
Protein
Domains/ Families for RAB5C(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P51148 ProtoNet protein and cluster: P51148
1 Blocks protein family : IPB001806 Transforming protein P21 RAS signature UniProtKB/Swiss-Prot: RAB5C_HUMAN, P51148 Similarity : Belongs to the small GTPase superfamily. Rab family
Gene Function for RAB5C
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
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OriGene , and/or
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siRNAs from
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_201434 Applied Biosystems Silencer ® siRNAs for RAB5C Sigma-Aldrich siRNA for RAB5C Sigma-Aldrich shRNA for RAB5C Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_004583                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_004583                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_004583  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004583 UniProtKB/Swiss-Prot: RAB5C_HUMAN, P51148 Function : Protein transport. Probably involved in vesicular traffic (By similarity)
Genatlas biochemistry entry for RAB5C :RAB5C,Ras oncogene superfamily member,involved in endocytosis 4 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for RAB5C
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for RAB5C (Your Favorite Gene powered by Ingenuity) Gene Network CentralTM Interacting Genes and Proteins Network for RAB5C 5/7 Interacting proteins for RAB5C (ENSP00000345689 3 P51148 1 ) via UniProtKB, MINT, and/or STRING (see all 7
)About this table 4 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0007032 endosome organization
IEA -- GO:0007264 small GTPase mediated signal transduction
IEA -- GO:0015031 protein transport
IEA -- GO:0030100 regulation of endocytosis
IEA --
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Drugs & Compounds for RAB5C (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Enzo Life Sciences drugs & compounds for RAB5C
Browse Tocris compounds for RAB5C 2 PharmGKB drug compound relationships for RAB5C gene About this table
Transcripts for RAB5C(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_201434 Sigma-Aldrich siRNA for RAB5C Sigma-Aldrich shRNA for RAB5C Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_004583 NM_201434
REFSEQ mRNAs for RAB5C gene (2 alternative transcripts): NM_004583.2 NM_201434.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004583 NM_201434
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_004583                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_004583                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_004583  
Additional cDNA sequence: AF141304.1 AF498938.1 AK310234.1 BC106039.1 BC114439.1 BT019484.1 CR541901.1 CR591636.1 CR591906.1 CR595237.1 CR595680.1 CR599091.1 CR600279.1 CR600565.1 CR601486.1 CR603551.1 CR607771.1 CR607787.1 CR608029.1 CR611639.1 CR612169.1 CR612483.1 CR613867.1 CR615479.1 CR617757.1 CR617879.1 CR620573.1 CR620653.1 CR621567.1 CR622103.1 CR623581.1 CR624854.1 CR625174.1 CR625641.1 CR626803.1 U11293.1 U18420.1
23 DOTS entries : DT.218551 DT.100674027 DT.99937115 DT.91773125 DT.100059392 DT.120956965 DT.97868410 DT.100674016 DT.120956948 DT.95255713 DT.100048907 DT.120956924 DT.120956947 DT.91645886 DT.100637732 DT.120956920 DT.120956963 DT.40240867 DT.95086308 DT.97868408 DT.92034962 DT.95229285 DT.95255752
24/939 AceView cDNA sequences (see all 939
):AI924879 AA039471 AW090218 AI634277 CR620573 BM851807 BQ005492 BQ014624 BE385553 BP378265 CB529464 BM552922 BX342944 BM795179 BG231732 CR622103 BQ921753 BM853755 BI836101 BI088209 AA133267 BQ477732 BG910375 BM705274
highest scoring ESTs for RAB5C :U18420 AA314438 AI751117 AL517079 AL517904 AL518497 AL530507 AL533620 AL541256 AL549052
Unigene Cluster for RAB5C: RAB5C, member RAS oncogene family Hs.650382 [show with all ESTs ] Unigene Representative Sequence: NM_201434 GeneLoc Exon Structure 5/13 Alternative Splicing Database (ASD) splice patterns (SP) for RAB5C (see all 13
) ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 SP1 :     -   -   -   -   -   -   -                 -   -               SP2 :     -   -     -   -   -   -                 -   -               SP3 :     -   -   -   -   -   -   -           -   -   -   -   -               SP4 :                               -   -   -               SP5 :     -   -   -   -   -   -   -     -   -   -   -   -   -   -   -   -   -          
About this scheme ECgene alternative splicing isoforms for RAB5C 2 Ensembl transcripts including schematic representations : ENST00000346213
ENST00000393860
Expression for RAB5C
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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RAB5C expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for RAB5C 1 / 2 / 3
5 probe-sets matching RAB5C gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TAACCAATCASOURCE GeneReport for Unigene cluster: Hs.650382 Expression variation in blood from EXPOLDB for RAB5C
Orthologs for RAB5C
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for RAB5C gene from 5/19 species (see all 19
)
About this table Species with no ortholog for RAB5C ENSEMBL Gene Tree for RAB5C Paralogs for RAB5C (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for RAB5C gene RAB5A 2 RAB5B 2 RAB17 2 Pseudogenes 2 related pseudogenes
SNPs/Variants for RAB5C (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for RAB5C (up to first 250kb)
Disorders & Mutations for RAB5C
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 604037 1 PharmGKB disease relationship for RAB5C gene About this table
Medical News for RAB5C (Possibly Related Articles in
Doctor's Guide )
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--
Publications for RAB5C (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/14 PubMed articles for RAB5C gene (see all 14
):
Search for RAB5C
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing RAB5C
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing RAB5C
(According to HUGE )
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Specialized Databases showing RAB5C (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for RAB5C (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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