Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RAB5B Gene

Aliases for RAB5B Gene

  • RAB5B, Member RAS Oncogene Family 2 3

External Ids for RAB5B Gene

Summaries for RAB5B Gene

GeneCards Summary for RAB5B Gene

RAB5B (RAB5B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Endocytosis. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB5C.

UniProtKB/Swiss-Prot for RAB5B Gene

  • Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Wiki entry for RAB5B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB5B Gene

Genomics for RAB5B Gene

Genomic Location for RAB5B Gene

Start:
55,973,913 bp from pter
End:
55,996,683 bp from pter
Size:
22,771 bases
Orientation:
Plus strand

Genomic View for RAB5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB5B Gene

Regulatory Elements for RAB5B Gene

Transcription factor binding sites by QIAGEN in the RAB5B gene promoter:

Proteins for RAB5B Gene

  • Protein details for RAB5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61020-RAB5B_HUMAN
    Recommended name:
    Ras-related protein Rab-5B
    Protein Accession:
    P61020
    Secondary Accessions:
    • A8K982
    • B4DKD7
    • P35239
    • P35277
    • Q6PIK9
    • Q86TH0
    • Q8IXL2

    Protein attributes for RAB5B Gene

    Size:
    215 amino acids
    Molecular mass:
    23707 Da
    Quaternary structure:
    • Binds EEA1. Interacts with RIN2 and RIN3, which probably regulate its pathway, possibly by acting as GEFs.
    SequenceCaution:
    • Sequence=AAH40143.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAB5B Gene

    Alternative splice isoforms for RAB5B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB5B Gene

Proteomics data for RAB5B Gene at MOPED

Post-translational modifications for RAB5B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys134

No data available for DME Specific Peptides for RAB5B Gene

Domains for RAB5B Gene

Gene Families for RAB5B Gene

HGNC:
  • RAB :RAB, member RAS oncogene

UniProtKB/Swiss-Prot:

RAB5B_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rab family.:
    • P61020
genes like me logo Genes that share domains with RAB5B: view

Function for RAB5B Gene

Molecular function for RAB5B Gene

GENATLAS Biochemistry: RAB5B,Ras oncogene superfamily member,involved in endocytosis,expressed in skeletal muscle
UniProtKB/Swiss-Prot EnzymeRegulation: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP
UniProtKB/Swiss-Prot Function: Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Ontology (GO) - Molecular Function for RAB5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 17562788
GO:0005515 protein binding IPI 10491193
GO:0005525 GTP binding IEA --
GO:0019003 GDP binding IDA 20937701
GO:0030742 GTP-dependent protein binding IDA 10491193
genes like me logo Genes that share ontologies with RAB5B: view

Phenotypes for RAB5B Gene

GenomeRNAi human phenotypes for RAB5B:
genes like me logo Genes that share phenotypes with RAB5B: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB5B Gene

Localization for RAB5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB5B Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Melanosome. Note=Enriched in stage I melanosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB5B Gene COMPARTMENTS Subcellular localization image for RAB5B gene
Compartment Confidence
endosome 5
plasma membrane 5
cytosol 3
mitochondrion 3

Gene Ontology (GO) - Cellular Components for RAB5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005768 endosome IDA 10491193
GO:0005769 early endosome IBA --
genes like me logo Genes that share ontologies with RAB5B: view

Pathways for RAB5B Gene

genes like me logo Genes that share pathways with RAB5B: view

Gene Ontology (GO) - Biological Process for RAB5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007032 endosome organization IEA --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RAB5B: view

Compounds for RAB5B Gene

(3) HMDB Compounds for RAB5B Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with RAB5B: view

Transcripts for RAB5B Gene

Unigene Clusters for RAB5B Gene

RAB5B, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB5B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d
SP1:
SP2: - - -
SP3: - -
SP4:
SP5: -
SP6:
SP7: - -

Relevant External Links for RAB5B Gene

GeneLoc Exon Structure for
RAB5B
ECgene alternative splicing isoforms for
RAB5B

Expression for RAB5B Gene

mRNA expression in normal human tissues for RAB5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB5B Gene

SOURCE GeneReport for Unigene cluster for RAB5B Gene Hs.157659

genes like me logo Genes that share expressions with RAB5B: view

Orthologs for RAB5B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB5B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB5B 36
  • 99.84 (n)
  • 100 (a)
RAB5B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB5B 36
  • 94.57 (n)
  • 99.53 (a)
RAB5B 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB5B 36
  • 95.35 (n)
  • 100 (a)
RAB5B 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab5b 36
  • 92.87 (n)
  • 100 (a)
Rab5b 16
Rab5b 37
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab5b 36
  • 92.56 (n)
  • 99.07 (a)
chicken
(Gallus gallus)
Aves RAB5B 36
  • 83.26 (n)
  • 96.28 (a)
RAB5B 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB5B 37
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3907 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rab5b 36
  • 80.31 (n)
  • 93.02 (a)
zebrafish
(Danio rerio)
Actinopterygii rab5b 37
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rab5 37
  • 71 (a)
OneToMany
Rab5 38
  • 74 (a)
chrw 38
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea rab-5 37
  • 77 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL084C 36
  • 55.44 (n)
  • 56.78 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS21 36
  • 59.54 (n)
  • 61.27 (a)
VPS21 37
  • 54 (a)
ManyToMany
YPT53 37
  • 42 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C13728g 36
  • 56.23 (n)
  • 58.08 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7710 36
rice
(Oryza sativa)
Liliopsida Os.11076 36
bread mold
(Neurospora crassa)
Ascomycetes NCU06410 36
  • 59.71 (n)
  • 59.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11163 37
  • 69 (a)
OneToMany
Species with no ortholog for RAB5B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB5B Gene

ENSEMBL:
Gene Tree for RAB5B (if available)
TreeFam:
Gene Tree for RAB5B (if available)

Paralogs for RAB5B Gene

Pseudogenes.org Pseudogenes for RAB5B Gene

genes like me logo Genes that share paralogs with RAB5B: view

Variants for RAB5B Gene

Sequence variations from dbSNP and Humsavar for RAB5B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs9323 -- 55,994,430(-) CGATA(C/G)GCCCA utr-variant-3-prime
rs11673 -- 55,994,548(-) AAAAC(G/T)GACCA utr-variant-3-prime
rs705698 -- 55,990,903(+) GACAT(C/T)CATTG intron-variant
rs705699 -- 55,991,020(-) GGTAC(C/T)TCCCT intron-variant
rs773107 -- 55,975,722(+) AGCCT(A/G)TTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB5B Gene

Variant ID Type Subtype PubMed ID
nsv832424 CNV Loss 17160897

Relevant External Links for RAB5B Gene

HapMap Linkage Disequilibrium report
RAB5B

Disorders for RAB5B Gene

Relevant External Links for RAB5B

Genetic Association Database (GAD)
RAB5B
Human Genome Epidemiology (HuGE) Navigator
RAB5B
genes like me logo Genes that share disorders with RAB5B: view

No data available for UniProtKB/Swiss-Prot for RAB5B Gene

Publications for RAB5B Gene

  1. Identification and subcellular localization of human rab5b, a new member of the ras-related superfamily of GTPases. (PMID: 1541686) Wilson D.B. … Wilson M.P. (J. Clin. Invest. 1992) 2 3 4 23
  2. Direct interaction of EEA1 with Rab5b. (PMID: 10491193) Callaghan J.M. … Stenmark H. (Eur. J. Biochem. 1999) 3 4 23
  3. The small GTPases Rab5a, Rab5b and Rab5c are differentially phosphorylated in vitro. (PMID: 10403367) Chiariello M. … Bucci C. (FEBS Lett. 1999) 2 3
  4. A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5. (PMID: 11733506) Saito K. … Katada T. (J. Biol. Chem. 2002) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RAB5B Gene

Sources for RAB5B Gene

Back to Top

Content