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Aliases for RAB5B Gene

Aliases for RAB5B Gene

  • RAB5B, Member RAS Oncogene Family 2 3

External Ids for RAB5B Gene

Previous GeneCards Identifiers for RAB5B Gene

  • GC12M056195
  • GC12P056944
  • GC12P056084
  • GC12P054654
  • GC12P056368
  • GC12P053407

Summaries for RAB5B Gene

GeneCards Summary for RAB5B Gene

RAB5B (RAB5B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Endocytosis. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB5C.

UniProtKB/Swiss-Prot for RAB5B Gene

  • Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Wiki entry for RAB5B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB5B Gene

Genomics for RAB5B Gene

Regulatory Elements for RAB5B Gene

Transcription factor binding sites by QIAGEN in the RAB5B gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAB5B Gene

55,973,913 bp from pter
55,996,683 bp from pter
22,771 bases
Plus strand

Genomic View for RAB5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB5B Gene

Proteins for RAB5B Gene

  • Protein details for RAB5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-5B
    Protein Accession:
    Secondary Accessions:
    • A8K982
    • B4DKD7
    • P35239
    • P35277
    • Q6PIK9
    • Q86TH0
    • Q8IXL2

    Protein attributes for RAB5B Gene

    215 amino acids
    Molecular mass:
    23707 Da
    Quaternary structure:
    • Binds EEA1. Interacts with RIN2 and RIN3, which probably regulate its pathway, possibly by acting as GEFs.
    • Sequence=AAH40143.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAB5B Gene

    Alternative splice isoforms for RAB5B Gene


neXtProt entry for RAB5B Gene

Proteomics data for RAB5B Gene at MOPED

Post-translational modifications for RAB5B Gene

  • Ubiquitination at Lys134
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for RAB5B Gene

Domains for RAB5B Gene

Gene Families for RAB5B Gene

  • RAB :RAB, member RAS oncogene

Suggested Antigen Peptide Sequences for RAB5B Gene

Graphical View of Domain Structure for InterPro Entry



  • P61020
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB5B: view

Function for RAB5B Gene

Molecular function for RAB5B Gene

GENATLAS Biochemistry:
RAB5B,Ras oncogene superfamily member,involved in endocytosis,expressed in skeletal muscle
UniProtKB/Swiss-Prot EnzymeRegulation:
Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP
UniProtKB/Swiss-Prot Function:
Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Ontology (GO) - Molecular Function for RAB5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 17562788
GO:0005515 protein binding IPI 10491193
GO:0005525 GTP binding IEA --
GO:0019003 GDP binding IDA 20937701
GO:0030742 GTP-dependent protein binding IDA 10491193
genes like me logo Genes that share ontologies with RAB5B: view

Phenotypes for RAB5B Gene

GenomeRNAi human phenotypes for RAB5B:
genes like me logo Genes that share phenotypes with RAB5B: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB5B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB5B Gene

Localization for RAB5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB5B Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Melanosome. Note=Enriched in stage I melanosomes.

Subcellular locations from

Jensen Localization Image for RAB5B Gene COMPARTMENTS Subcellular localization image for RAB5B gene
Compartment Confidence
endosome 5
plasma membrane 5
cytosol 3
mitochondrion 3

Gene Ontology (GO) - Cellular Components for RAB5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005768 endosome IDA 10491193
GO:0005769 early endosome IBA --
genes like me logo Genes that share ontologies with RAB5B: view

Pathways for RAB5B Gene

genes like me logo Genes that share pathways with RAB5B: view

Gene Ontology (GO) - Biological Process for RAB5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007032 endosome organization IEA --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RAB5B: view

Compounds for RAB5B Gene

(3) HMDB Compounds for RAB5B Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
Guanosine monophosphate
  • 5'-GMP
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with RAB5B: view

Transcripts for RAB5B Gene

Unigene Clusters for RAB5B Gene

RAB5B, member RAS oncogene family:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB5B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB5B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d
SP2: - - -
SP3: - -
SP5: -
SP7: - -

Relevant External Links for RAB5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB5B Gene

mRNA expression in normal human tissues for RAB5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RAB5B Gene

This gene is overexpressed in Nasal epithelium (10.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB5B Gene

SOURCE GeneReport for Unigene cluster for RAB5B Gene Hs.157659

genes like me logo Genes that share expressions with RAB5B: view

Expression partners for RAB5B Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAB5B Gene

Orthologs for RAB5B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB5B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RAB5B 35
  • 94.57 (n)
  • 99.53 (a)
RAB5B 36
  • 93 (a)
(Canis familiaris)
Mammalia RAB5B 35
  • 95.35 (n)
  • 100 (a)
RAB5B 36
  • 100 (a)
(Mus musculus)
Mammalia Rab5b 35
  • 92.87 (n)
  • 100 (a)
Rab5b 16
Rab5b 36
  • 100 (a)
(Pan troglodytes)
Mammalia RAB5B 35
  • 99.84 (n)
  • 100 (a)
RAB5B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rab5b 35
  • 92.56 (n)
  • 99.07 (a)
(Gallus gallus)
Aves RAB5B 35
  • 83.26 (n)
  • 96.28 (a)
RAB5B 36
  • 97 (a)
(Anolis carolinensis)
Reptilia RAB5B 36
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab5b 35
  • 80.31 (n)
  • 93.02 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3907 35
(Danio rerio)
Actinopterygii rab5b 36
  • 77 (a)
fruit fly
(Drosophila melanogaster)
Insecta chrw 37
  • 41 (a)
Rab5 37
  • 74 (a)
Rab5 36
  • 71 (a)
(Caenorhabditis elegans)
Secernentea rab-5 36
  • 77 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL084C 35
  • 55.44 (n)
  • 56.78 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C13728g 35
  • 56.23 (n)
  • 58.08 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS21 35
  • 59.54 (n)
  • 61.27 (a)
VPS21 36
  • 54 (a)
YPT53 36
  • 42 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7710 35
(Oryza sativa)
Liliopsida Os.11076 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06410 35
  • 59.71 (n)
  • 59.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11163 36
  • 69 (a)
Species with no ortholog for RAB5B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB5B Gene

Gene Tree for RAB5B (if available)
Gene Tree for RAB5B (if available)

Paralogs for RAB5B Gene Pseudogenes for RAB5B Gene

genes like me logo Genes that share paralogs with RAB5B: view

Variants for RAB5B Gene

Sequence variations from dbSNP and Humsavar for RAB5B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs9323 -- 55,994,430(-) CGATA(C/G)GCCCA utr-variant-3-prime
rs11673 -- 55,994,548(-) AAAAC(G/T)GACCA utr-variant-3-prime
rs705698 -- 55,990,903(+) GACAT(C/T)CATTG intron-variant
rs705699 -- 55,991,020(-) GGTAC(C/T)TCCCT intron-variant
rs773107 -- 55,975,722(+) AGCCT(A/G)TTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB5B Gene

Variant ID Type Subtype PubMed ID
nsv832424 CNV Loss 17160897

Relevant External Links for RAB5B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB5B Gene

Disorders for RAB5B Gene

Relevant External Links for RAB5B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for RAB5B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RAB5B Gene

Publications for RAB5B Gene

  1. Identification and subcellular localization of human rab5b, a new member of the ras-related superfamily of GTPases. (PMID: 1541686) Wilson D.B. … Wilson M.P. (J. Clin. Invest. 1992) 2 3 4 23
  2. Direct interaction of EEA1 with Rab5b. (PMID: 10491193) Callaghan J.M. … Stenmark H. (Eur. J. Biochem. 1999) 3 4 23
  3. The small GTPases Rab5a, Rab5b and Rab5c are differentially phosphorylated in vitro. (PMID: 10403367) Chiariello M. … Bucci C. (FEBS Lett. 1999) 2 3
  4. A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5. (PMID: 11733506) Saito K. … Katada T. (J. Biol. Chem. 2002) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RAB5B Gene

Sources for RAB5B Gene

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