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RAB5B Gene

protein-coding   GIFtS: 63
GCID: GC12P056368

RAB5B, Member RAS Oncogene Family

  Search for RAB5B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAB5B, Member RAS Oncogene Family1 2
Ras-Related Protein Rab-5B2

External Ids:    HGNC: 97841   Entrez Gene: 58692   Ensembl: ENSG000001115407   OMIM: 1795145   UniProtKB: P610203   

Export aliases for RAB5B gene to outside databases

Previous GC identifers: GC12M056195 GC12P056944 GC12P056084 GC12P054654 GC12P053407


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RAB5B Gene:
RAB5B (RAB5B, member RAS oncogene family) is a protein-coding gene. GO annotations related to this gene include GDP binding and GTP binding. An important paralog of this gene is RAB20.

UniProtKB/Swiss-Prot: RAB5B_HUMAN, P61020
Function: Protein transport. Probably involved in vesicular traffic (By similarity)

Gene Wiki entry for RAB5B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAB5B gene promoter:
         C/EBPbeta   Sp1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): RAB5B promoter sequence
   Search Chromatin IP Primers for RAB5B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAB5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13

RAB5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB5B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P056368:  view genomic region     (about GC identifiers)

Start:
56,367,697 bp from pter      End:
56,388,490 bp from pter
Size:
20,794 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RAB5B_HUMAN, P61020 (See protein sequence)
Recommended Name: Ras-related protein Rab-5B  
Size: 215 amino acids; 23707 Da
Subunit: Binds EEA1. Interacts with RIN2 and RIN3, which probably regulate its pathway, possibly by acting as GEFs
Sequence caution: Sequence=AAH40143.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for RAB5B:
2HEI (3D)    
Secondary accessions: A8K982 B4DKD7 P35239 P35277 Q6PIK9 Q86TH0 Q8IXL2
Alternative splicing: 2 isoforms:  P61020-1   P61020-2   

Explore the universe of human proteins at neXtProt for RAB5B: NX_P61020

Explore proteomics data for RAB5B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys134
  • Modification sites at PhosphoSitePlus

  • See RAB5B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001238965.1  NP_001238966.1  NP_002859.1  

    ENSEMBL proteins: 
     ENSP00000450168   ENSP00000353444   ENSP00000450285   ENSP00000447895   ENSP00000449762  
     ENSP00000449554   ENSP00000391319  

    RAB5B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P61020

    ProtoNet protein and cluster: P61020

    3 Blocks protein domains:
    IPB002041 GTP-binding nuclear protein Ran
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RAB5B_HUMAN, P61020
    Similarity: Belongs to the small GTPase superfamily. Rab family


    Find genes that share domains with RAB5B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAB5B_HUMAN, P61020
    Function: Protein transport. Probably involved in vesicular traffic (By similarity)
    Enzyme regulation: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP
    for free GTP

         Genatlas biochemistry entry for RAB5B:
    RAB5B,Ras oncogene superfamily member,involved in endocytosis,expressed in skeletal muscle

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS1541686
    GO:0005515protein binding IPI10491193
    GO:0005525GTP binding IEA--
    GO:0019003GDP binding IDA--
    GO:0030742GTP-dependent protein binding IDA10491193
         
    Find genes that share ontologies with RAB5B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RAB5B:
     Synthetic lethal with Ras 

         1 MGI phenotypic allele for Rab5b (no phenotypes)

    Find genes that share phenotypes with RAB5B           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAB5B
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    Block miRNA regulation of human, mouse, rat RAB5B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAB5B (see all 117):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-1914* hsa-miR-106a hsa-miR-374a hsa-miR-519a hsa-miR-3916 hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidRAB5B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RAB5B

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    eBioscience FlowRNA Probe Sets ( VA1-12226) for RAB5B 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RAB5B_HUMAN, P61020: Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor.
    Melanosome. Note=Enriched in stage I melanosomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane5
    cytosol3
    mitochondrion3

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005768endosome IDA10491193
    GO:0005886plasma membrane IEA--

    Find genes that share ontologies with RAB5B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAB5B About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    2Ras signaling pathway
    Ras signaling pathway0.36
    3Vasopressin-regulated water reabsorption
    Vasopressin-regulated water reabsorption
    4Tuberculosis
    Tuberculosis
    5SMAD Signaling Network
    SMAD Signaling Network


    Find genes that share SuperPaths with RAB5B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RAB5B
        SMAD Signaling Network
    Remodeling of Adherens Junctions
    Epithelial Tight Junctions



    Selected Kegg Pathways  (Kegg details for RAB5B) (see all 6):
        Ras signaling pathway
    Endocytosis
    Phagosome
    Vasopressin-regulated water reabsorption
    Amoebiasis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RAB5B
    Interactions:

        GeneGlobe Interaction Network for RAB5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAB5B (P610201, 3 ENSP000003534444) via UniProtKB, MINT, STRING, and/or I2D (see all 184)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEA1Q150751, 3, ENSP000003179554EBI-399401,EBI-298113 I2D: score=2 STRING: ENSP00000317955
    ALDH5A1P516493, ENSP000003146494I2D: score=4 STRING: ENSP00000314649
    RIN2Q8WYP33, ENSP000002550064I2D: score=3 STRING: ENSP00000255006
    RIN1Q136713, ENSP000003104064I2D: score=2 STRING: ENSP00000310406
    RIN3Q8TB243, ENSP000002164874I2D: score=2 STRING: ENSP00000216487
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS1541686
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007032endosome organization IEA--
    GO:0007165signal transduction ----

    Find genes that share ontologies with RAB5B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAB5B

    3 HMDB Compounds for RAB5B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RAB5B gene (3 alternative transcripts): 
    NM_001252036.1  NM_001252037.1  NM_002868.3  

    Unigene Cluster for RAB5B:

    RAB5B, member RAS oncogene family
    Hs.157659  [show with all ESTs]
    Unigene Representative Sequence: NM_002868
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000553116(uc001siv.3) ENST00000360299(uc001siw.3 uc010spz.2 uc009zog.3)
    ENST00000549505 ENST00000546810 ENST00000548068 ENST00000549915 ENST00000551459
    ENST00000448789 ENST00000549034 ENST00000550283
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    hsa-miR-323-3p hsa-miR-607 hsa-miR-1914* hsa-miR-106a hsa-miR-374a hsa-miR-519a hsa-miR-3916 hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidRAB5B 3' UTR sequence
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    Additional mRNA sequence: 

    AF267863.1 AF498937.1 AK292597.1 AK296517.1 AK307468.1 BC032740.1 BC040143.1 BC050558.1 
    BC056422.1 BC065298.1 BX537408.1 BX647808.1 CR536482.1 CR541690.1 X54871.1 

    22 DOTS entries:

    DT.95163364  DT.449878  DT.91753780  DT.95310391  DT.100884665  DT.100884674  DT.101988020  DT.447954 
    DT.92047495  DT.97774344  DT.100884668  DT.101988019  DT.121176035  DT.91753772  DT.95232705  DT.97782336 
    DT.100782988  DT.100830065  DT.102831914  DT.428262  DT.92391355  DT.95163374 

    Selected AceView cDNA sequences (see all 451):

    BU844864 CF242896 C05042 BU193195 CK724947 BX647808 BQ949360 BM727209 
    BX537408 T31857 T31306 CB137079 AW055037 CR594499 BQ650964 CB137244 
    AI341783 BF725398 CD519651 AI709020 BG057087 BC040143 CR614791 BE766593 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RAB5B (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d
    SP1:                                                                                          
    SP2:                                                        -     -     -                     
    SP3:                          -     -                                                         
    SP4:                                                                                          
    SP5:                                      -                                                   


    ECgene alternative splicing isoforms for RAB5B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAB5B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCTGAAAC
    RAB5B Expression
    About this image


    RAB5B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
     
     Lung (Respiratory System)
    RAB5B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAB5B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.157659
        Custom PCR Arrays for RAB5B
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB5B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAB5B gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab5b1 , 5 RAB5B, member RAS oncogene family1, 5 92.87(n)1
    100(a)1
      10 (77.13 cM)5
    193441  NM_177411.41  NP_803130.11 
     1286771935 
    chicken
    (Gallus gallus)
    Aves RAB5B1 RAB5B, member RAS oncogene family 83.26(n)
    96.28(a)
      100529061  NM_001199848.1  NP_001186777.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAB5B6
    RAB5B, member RAS oncogene family
    96(a)
    1 ↔ 1
    GL343198.1(3390349-3424355)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.39072 Xenopus laevis transcribed sequence with strong similarity more 80.13(n)    BX847844.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rab5b6
    RAB5B, member RAS oncogene family
    77(a)
    1 ↔ 1
    9(28784087-28823963) ENSDARG00000016059
    fruit fly
    (Drosophila melanogaster)
    Insecta Rab53 establishment and/or maintenance of
    chromatin more
    74(a)
    (best of 2)
      22E1   --
    worm
    (Caenorhabditis elegans)
    Secernentea rab-56
    Protein RAB-5 (rab-5) mRNA, complete cds
    77(a)
    1 → many
    I(9308442-9310221) WBGene00004268
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS211 VPS21 59.54(n)
    61.27(a)
      854256   NP_014732.1 
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.77102 Vitis vinifera transcribed sequence with moderate similarity more 74.1(n)    CB971249.1 
    rice
    (Oryza sativa)
    Liliopsida Os.110762 Oryza sativa mRNA for RAB5A protein 72.2(n)    AK061116.1 


    ENSEMBL Gene Tree for RAB5B (if available)
    TreeFam Gene Tree for RAB5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAB5B gene
    RAB202  RAB5C2  ENSG000002672612  RAB312  RAB212  RAB5A2  RAB242  RAB22A2  
    RAB172  
    Selected SIMAP similar genes for RAB5B using alignment to 6 protein entries:     RAB5B_HUMAN (see all proteins) (see all similar genes):
    RAB5C    RAB5A    rab1b    DKFZp686J06205    RAB11A    RAB22A
    RAB6B    RAB11B    RAB39B    RAB6A    RAB30    RAB6A'
    RAB15    RAB24    RAB31    DKFZp686J07132    RAB25    DKFZp313C1541

    Find genes that share paralogs with RAB5B           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RAB5B
    PGOHUM00000261394


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAB5B (see all 424)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22711931,2
    C,F,H--56367342(-) CTTCTA/GTGACA 3 -- us2k17Minor allele frequency- G:0.01EA NS 2248
    rs32131291,2
    C,F,H--56367386(+) GGGGGA/TGGGGC 3 -- us2k1 tfbs3 trp34Minor allele frequency- T:0.00NS EA 472
    rs1905130601,2
    --56367521(+) ATGTTC/TATGAG 3 -- us2k10--------
    rs1441458451,2
    --56367556(+) CGAGAG/TTTTAT 3 -- us2k10--------
    rs1817251461,2
    --56367625(+) TTAATA/GGCTCC 3 -- us2k10--------
    rs1867971811,2
    --56367629(+) TGGCTC/TCTTAC 3 -- us2k10--------
    rs795941861,2
    C--56367662(+) CCCTCA/GCTATT 3 -- us2k10--------
    rs2019986041,2
    C--56367673(+) GGCTTG/TTGGCC 3 -- us2k10--------
    rs756390741,2
    C,F--56367901(+) GGGGCC/GGACGG 3 -- ut51 int11Minor allele frequency- G:0.10NA 120
    rs802234101,2
    C,F--56367966(+) GCGCCC/TGGGAG 3 -- int12Minor allele frequency- T:0.08NA 122

    HapMap Linkage Disequilibrium report for RAB5B (56367697 - 56388490 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RAB5B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832424CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAB5B
    DNA2.0 Custom Variant and Variant Library Synthesis for RAB5B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 179514    OMIM disorders: --


    Find genes that share disorders with RAB5B           About GenesLikeMe

    Genetic Association Database (GAD): RAB5B
    Human Genome Epidemiology (HuGE) Navigator: RAB5B (2 documents)

    Export disorders for RAB5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAB5B gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with RAB5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and subcellular localization of human rab5b, a new member of the ras-related superfamily of GTPases. (PubMed id 1541686)1, 2, 3, 9 Wilson D.B. and Wilson M.P. (J. Clin. Invest. 1992)
    2. Direct interaction of EEA1 with Rab5b. (PubMed id 10491193)1, 2, 9 Callaghan J.M.... Stenmark H. (Eur. J. Biochem. 1999)
    3. Common variants in FOXP1 are associated with generalized vitiligo. (PubMed id 20526340)1, 4 Jin Y....Spritz R.A. (Nat. Genet. 2010)
    4. A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. (PubMed id 18198356)1, 4 Hakonarson H....Polychronakos C. (Diabetes 2008)
    5. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5. (PubMed id 11733506)1, 2 Saito K.... Katada T. (J. Biol. Chem. 2002)
    8. The small GTPases Rab5a, Rab5b and Rab5c are differentially phosphorylated in vitro. (PubMed id 10403367)1, 3 Chiariello M....Bucci C. (FEBS Lett. 1999)
    9. Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population. (PubMed id 22951725)1 Tang X.F....Zhang X.J. (J. Invest. Dermatol. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5869 HGNC: 9784 AceView: RAB5B Ensembl:ENSG00000111540 euGenes: HUgn5869
    ECgene: RAB5B Kegg: 5869 H-InvDB: RAB5B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RAB5B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB5B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAB5B gene:
    Search GeneIP for patents involving RAB5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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