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Aliases & Descriptions for RAB5B
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| RAB5B, member RAS oncogene family 2 |
|
| | Search outside databases for aliases for RAB5B genePrevious GC identifers: GC12M056195 GC12P056944 GC12P056084 |
Summaries for RAB5B(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: RAB5B_HUMAN, P61020Function: Protein transport. Probably involved in vesicular traffic (By similarity)Gene Wiki entry for RAB5B |
Genomic Location for RAB5B
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RAB5B gene 
Entrez Gene cytogenetic band: 12q13 Ensembl cytogenetic band: 12q13.2 HGNC cytogenetic band: 12q13RAB5B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P054654:
(about GC identifiers)
Start:
|
54,654,125 bp from pter |
End:
|
54,674,757 bp from pter |
Size:
|
20,633 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000012.10 NT_029419.11
| Proteins for RAB5B
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RAB5B_HUMAN, P61020 (See
protein sequence)Recommended Name: Ras-related protein Rab-5B Size: 215 amino acids; 23707 Da
Subunit: Binds EEA1. Interacts with RIN2 and RIN3, which probably regulate its pathway, possibly by acting as GEFs
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Melanosome. Note=Enriched in stage I melanosomes
PDB structures from and Proteopedia :2HEI (3D)
 
Secondary accessions: P35239 P35277 Q6PIK9 Q86TH0 Q8IXL2Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002859.1
ENSEMBL proteins: ENSP00000353444
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7
): About this table
Antibodies for RAB5B: Assays for RAB5B: | Protein
Domains/ Families for RAB5B(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P61020
ProtoNet protein and cluster: P61020 3 Blocks protein families: IPB002041 GTP-binding nuclear protein Ran IPB003577 Ras small GTPase IPB003578 Ras small GTPase
UniProtKB/Swiss-Prot: RAB5B_HUMAN, P61020Similarity: Belongs to the small GTPase superfamily. Rab family | Gene Function for RAB5B
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002868
Applied Biosystems Silencer® siRNAs for RAB5B
Sigma-Aldrich siRNA for RAB5B  Sigma-Aldrich shRNA for RAB5B  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002868                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002868                                  untagged cDNA clone in CMV expression vector: NM_002868 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_002868
UniProtKB/Swiss-Prot: RAB5B_HUMAN, P61020Function: Protein transport. Probably involved in vesicular traffic (By similarity)Enzyme regulation: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTPGenatlas biochemistry entry for RAB5B:RAB5B,Ras oncogene superfamily member,involved in endocytosis,expressed in skeletal muscle4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for RAB5B
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 3 Sigma-Aldrich "Your Favorite Gene" Pathways for RAB5B (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for RAB5B 
5 Interacting proteins for RAB5B (P610201 ENSP000003534443) via UniProtKB, MINT, and/or STRINGAbout this table
4 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007032 | endosome organization |
IEA | -- | | GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- | | GO:0030100 | regulation of endocytosis |
IEA | -- | About this table
|
Drugs & Compounds for RAB5B(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for RAB5B |
Browse Tocris compounds for RAB5B
|
Transcripts for RAB5B(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002868
Sigma-Aldrich siRNA for RAB5B  Sigma-Aldrich shRNA for RAB5B  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_002868 REFSEQ mRNAs for RAB5B gene: NM_002868.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002868               OriGene GFP tagged cDNA clone in CMV expression vector: NM_002868                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002868                                  untagged cDNA clone in CMV expression vector: NM_002868  Additional cDNA sequence: AF267863.1 AF498937.1 AK292597.1 AK296517.1 AK307468.1 BC032740.1 BC040143.1 BC050558.1 BC056422.1 BC065298.1 BX537408.1 BX647808.1 CR536482.1 CR541690.1 CR594499.1 CR597002.1 CR614791.1 CR621175.1 X54871.1 16 DOTS entries: DT.95163364 DT.449878 DT.91753780 DT.95310391 DT.100884665 DT.100884674 DT.101988020 DT.102831914 DT.100884668 DT.101988019 DT.121176035 DT.91753772 DT.92049768 DT.97782336 DT.100830065 DT.95163374 24/451 AceView cDNA sequences (see all 451
):BM727209 BU184297 BE350213 BC065298 D25759 CB139940 NM_002868 AI203761 BX537408 BU193195 AL709073 AL708561 T31857 CF242896 BC040143 AI201796 AL597347 AA782248 BF725398 CB138948 BX384213 BQ216670 BM548884 BM842983
highest scoring ESTs for RAB5B:X54871 AA058838 AA059355 AA099203 AA099663 AA214320 AA214440 AA219377 AA310272 AA322846 Unigene Cluster for RAB5B: RAB5B, member RAS oncogene family Hs.567328 [show with all ESTs]Unigene Representative Sequence: BX537408
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RAB5B (see all 7
)
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | · | 9d | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for RAB5B
1 Ensembl transcript including schematic representation: ENST00000360299
|
Expression for RAB5B
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RAB5B expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RAB5B
1 / 2 / 3 4 probe-sets matching RAB5B gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCCCTGAAAC
SOURCE GeneReport for Unigene cluster: Hs.567328
Expression variation in blood from EXPOLDB for RAB5B |
Orthologs for RAB5B
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB5B gene from 5/16 species (see all 16
)
About this table Species with no ortholog for RAB5B
ENSEMBL Gene Tree for RAB5B | Paralogs for RAB5B(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RAB5B gene
- RAB5C2 RAB5A2 RAB172
|
SNPs/Variants for RAB5B(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RAB5B (up to first 250kb)
|
Disorders & Mutations for RAB5B
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 179514
Human Genome Epidemiology Navigator: RAB5B (1 document)
|
Medical News for RAB5B(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RAB5B (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/23 PubMed articles for RAB5B gene (see all 23
):- Identification and subcellular localization of human rab5b, a new member of the ras-related superfamily of GTPases. (PubMed id 1541686)1, 2, 3, 4 Wilson D.B. and Wilson M.P. (1992)
- Direct interaction of EEA1 with Rab5b. (PubMed id 10491193)1, 3, 4 Callaghan J.M.... Stenmark H. (1999)
- Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)3, 4 Chi A....Hunt D.F. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5. (PubMed id 11733506)3, 4 Saito K.... Katada T. (2002)
- The small GTPases Rab5a, Rab5b and Rab5c are differentially phosphorylated in vitro. (PubMed id 10403367)2, 3 Chiariello M....Bucci C. (1999)
- LRRK2 regulates synaptic vesicle endocytosis. (PubMed id 18445495)3 Shin N....Seol W. (2008)
- A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. (PubMed id 18198356)3 Hakonarson H....Polychronakos C. (2008)
- A role for Rab5 activity in the biogenesis of endosomal and lysosomal compartments. (PubMed id 17927960)3 Hirota Y....Tanaka Y. (2007)
- The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)4 Bechtel S....Schupp I. (2007)
|
Search for RAB5B
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RAB5B
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RAB5B
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB5B(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RAB5B(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RAB5B:

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Incremental update: 13 Oct 2009
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