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Aliases for RAB5B Gene

Aliases for RAB5B Gene

  • RAB5B, Member RAS Oncogene Family 2 3 5

External Ids for RAB5B Gene

Previous GeneCards Identifiers for RAB5B Gene

  • GC12M056195
  • GC12P056944
  • GC12P056084
  • GC12P054654
  • GC12P056368
  • GC12P053407

Summaries for RAB5B Gene

GeneCards Summary for RAB5B Gene

RAB5B (RAB5B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Endocytosis. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB5C.

UniProtKB/Swiss-Prot for RAB5B Gene

  • Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Wiki entry for RAB5B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB5B Gene

Genomics for RAB5B Gene

Regulatory Elements for RAB5B Gene

Promoters for RAB5B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAB5B on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the RAB5B gene promoter:

Genomic Location for RAB5B Gene

Chromosome:
12
Start:
55,973,913 bp from pter
End:
55,996,683 bp from pter
Size:
22,771 bases
Orientation:
Plus strand

Genomic View for RAB5B Gene

Genes around RAB5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB5B Gene

Proteins for RAB5B Gene

  • Protein details for RAB5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61020-RAB5B_HUMAN
    Recommended name:
    Ras-related protein Rab-5B
    Protein Accession:
    P61020
    Secondary Accessions:
    • A8K982
    • B4DKD7
    • P35239
    • P35277
    • Q6PIK9
    • Q86TH0
    • Q8IXL2

    Protein attributes for RAB5B Gene

    Size:
    215 amino acids
    Molecular mass:
    23707 Da
    Quaternary structure:
    • Binds EEA1. Interacts with RIN2 and RIN3, which probably regulate its pathway, possibly by acting as GEFs.
    SequenceCaution:
    • Sequence=AAH40143.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAB5B Gene

    Alternative splice isoforms for RAB5B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB5B Gene

Proteomics data for RAB5B Gene at MOPED

Post-translational modifications for RAB5B Gene

  • Ubiquitination at Lys 134
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RAB5B Gene

Domains & Families for RAB5B Gene

Gene Families for RAB5B Gene

Suggested Antigen Peptide Sequences for RAB5B Gene

Graphical View of Domain Structure for InterPro Entry

P61020

UniProtKB/Swiss-Prot:

RAB5B_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB5B: view

Function for RAB5B Gene

Molecular function for RAB5B Gene

GENATLAS Biochemistry:
RAB5B,Ras oncogene superfamily member,involved in endocytosis,expressed in skeletal muscle
UniProtKB/Swiss-Prot EnzymeRegulation:
Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP.
UniProtKB/Swiss-Prot Function:
Protein transport. Probably involved in vesicular traffic (By similarity).
genes like me logo Genes that share phenotypes with RAB5B: view

Animal Model Products

miRNA for RAB5B Gene

miRTarBase miRNAs that target RAB5B

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB5B Gene

Localization for RAB5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB5B Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Melanosome. Note=Enriched in stage I melanosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB5B Gene COMPARTMENTS Subcellular localization image for RAB5B gene
Compartment Confidence
endosome 5
extracellular 5
plasma membrane 4
cytosol 3
mitochondrion 3
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RAB5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA 10491193
GO:0005769 early endosome IBA --
GO:0031901 early endosome membrane IEA --
GO:0042470 melanosome IEA --
genes like me logo Genes that share ontologies with RAB5B: view

Pathways & Interactions for RAB5B Gene

genes like me logo Genes that share pathways with RAB5B: view

SIGNOR curated interactions for RAB5B Gene

Other effect:

Gene Ontology (GO) - Biological Process for RAB5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019882 antigen processing and presentation IMP 19717423
GO:0048227 plasma membrane to endosome transport IMP 17562788
genes like me logo Genes that share ontologies with RAB5B: view

Drugs & Compounds for RAB5B Gene

(3) Drugs for RAB5B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RAB5B: view

Transcripts for RAB5B Gene

Unigene Clusters for RAB5B Gene

RAB5B, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB5B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d
SP1:
SP2: - - -
SP3: - -
SP4:
SP5: -
SP6:
SP7: - -

Relevant External Links for RAB5B Gene

GeneLoc Exon Structure for
RAB5B
ECgene alternative splicing isoforms for
RAB5B

Expression for RAB5B Gene

mRNA expression in normal human tissues for RAB5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAB5B Gene

This gene is overexpressed in Nasal epithelium (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB5B Gene



SOURCE GeneReport for Unigene cluster for RAB5B Gene Hs.157659

genes like me logo Genes that share expression patterns with RAB5B: view

Protein tissue co-expression partners for RAB5B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAB5B Gene

Orthologs for RAB5B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB5B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAB5B 35
  • 94.57 (n)
  • 99.53 (a)
RAB5B 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB5B 35
  • 95.35 (n)
  • 100 (a)
RAB5B 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab5b 35
  • 92.87 (n)
  • 100 (a)
Rab5b 16
Rab5b 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAB5B 35
  • 99.84 (n)
  • 100 (a)
RAB5B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab5b 35
  • 92.56 (n)
  • 99.07 (a)
chicken
(Gallus gallus)
Aves RAB5B 35
  • 83.26 (n)
  • 96.28 (a)
RAB5B 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB5B 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab5b 35
  • 80.31 (n)
  • 93.02 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3907 35
zebrafish
(Danio rerio)
Actinopterygii rab5b 36
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta chrw 37
  • 41 (a)
Rab5 37
  • 74 (a)
Rab5 36
  • 71 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rab-5 36
  • 77 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL084C 35
  • 55.44 (n)
  • 56.78 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C13728g 35
  • 56.23 (n)
  • 58.08 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS21 35
  • 59.54 (n)
  • 61.27 (a)
VPS21 36
  • 54 (a)
ManyToMany
YPT53 36
  • 42 (a)
ManyToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7710 35
rice
(Oryza sativa)
Liliopsida Os.11076 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06410 35
  • 59.71 (n)
  • 59.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11163 36
  • 69 (a)
OneToMany
Species with no ortholog for RAB5B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB5B Gene

ENSEMBL:
Gene Tree for RAB5B (if available)
TreeFam:
Gene Tree for RAB5B (if available)

Paralogs for RAB5B Gene

Pseudogenes.org Pseudogenes for RAB5B Gene

genes like me logo Genes that share paralogs with RAB5B: view

Variants for RAB5B Gene

Sequence variations from dbSNP and Humsavar for RAB5B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs9323 -- 55,994,430(-) CGATA(C/G)GCCCA utr-variant-3-prime
rs11673 -- 55,994,548(-) AAAAC(G/T)GACCA utr-variant-3-prime
rs705698 -- 55,990,903(+) GACAT(C/T)CATTG intron-variant
rs705699 -- 55,991,020(-) GGTAC(C/T)TCCCT intron-variant
rs1050198 -- 55,992,268(+) TAACC(G/T)CCATC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RAB5B Gene

Variant ID Type Subtype PubMed ID
nsv832424 CNV Loss 17160897

Variation tolerance for RAB5B Gene

Residual Variation Intolerance Score: 60.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB5B Gene

HapMap Linkage Disequilibrium report
RAB5B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB5B Gene

Disorders for RAB5B Gene

Relevant External Links for RAB5B

Genetic Association Database (GAD)
RAB5B
Human Genome Epidemiology (HuGE) Navigator
RAB5B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB5B

No disorders were found for RAB5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB5B Gene

Publications for RAB5B Gene

  1. Identification and subcellular localization of human rab5b, a new member of the ras-related superfamily of GTPases. (PMID: 1541686) Wilson D.B. … Wilson M.P. (J. Clin. Invest. 1992) 2 3 4 23 67
  2. The small GTPases Rab5a, Rab5b and Rab5c are differentially phosphorylated in vitro. (PMID: 10403367) Chiariello M. … Bucci C. (FEBS Lett. 1999) 2 3
  3. Direct interaction of EEA1 with Rab5b. (PMID: 10491193) Callaghan J.M. … Stenmark H. (Eur. J. Biochem. 1999) 3 23
  4. An early endosome regulator, Rab5b, is an LRRK2 kinase substrate. (PMID: 25605758) Yun H.J. … Seol W. (J. Biochem. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for RAB5B Gene

Sources for RAB5B Gene

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