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RAB5A Gene

protein-coding GIFtS: 66

GC03P019963

RAB5A, member RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: RAB5)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
RAB5 ^², ³, ⁵

Descriptions
RAB5A, member RAS oncogene family ^²
RAS-associated protein RAB5A ^²

External Ids
HGNC: 9783¹
Entrez Gene: 5868²
UniProtKB: P20339³
Ensembl: ENSG00000144566⁷

Search outside databases for aliases for RAB5A gene

Previous GC identifers: GC03P019319 GC03M019342 GC03P019838

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: RAB5A_HUMAN, P20339

Function: Required for the fusion of plasma membranes and early endosomes

Gene Wiki entry for RAB5A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RAB5A gene

Entrez Gene cytogenetic band: 3p24-p22 Ensembl cytogenetic band: 3p24.3 HGNC cytogenetic band: 3p24-p22

RAB5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P019963: (about GC identifiers)

Start:	19,963,749 bp from pter
End:	20,001,647 bp from pter
Size:	37,899 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RAB5A_HUMAN, P20339 (See protein sequence)

Recommended Name: Ras-related protein Rab-5A

Size: 215 amino acids; 23659 Da

Subunit: Binds EEA1. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting

as a GEF. Interacts with ALS2CL, UNC84B, ZFYVE20 and RUFY1. Interacts with SGSM1 and SGSM3 (By

similarity)

Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Early endosome

membrane; Lipid-anchor (By similarity). Melanosome. Note=Enriched in stage I melanosomes

PDB structures from and Proteopedia :

1N6H (3D)

1N6I (3D)

1N6K (3D)

1N6L (3D)

1N6N (3D)

1N6O (3D)

1N6P (3D)

1N6R (3D)

1R2Q (3D)

1TU3 (3D)

1TU4 (3D)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004153.2

ENSEMBL proteins:

ENSP00000273047

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Rab5)
	Human Recombinant Proteins from Abnova (RAB5A)

OriGene Purified Recombinant Human Protein: RAB5A

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001726	ruffle	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0030139	endocytic vesicle	IEA	--
GO:0031901	early endosome membrane	IEA	--
GO:0042470	melanosome	IEA	--

About this table

Antibodies for RAB5A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for RAB5A
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for RAB5A (Rab5)
	Antibodies from Abcam (Rab5), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (RAB5A)
	Novus Biologicals Antibodies for RAB5A

Assays for RAB5A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P20339

ProtoNet protein and cluster: P20339

1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature

UniProtKB/Swiss-Prot: RAB5A_HUMAN, P20339

Similarity: Belongs to the small GTPase superfamily. Rab family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RAB5A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RAB5A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004162

Applied Biosystems Silencer® siRNAs for RAB5A

Sigma-Aldrich siRNA for RAB5A

Sigma-Aldrich shRNA for RAB5A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for RAB5A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004162
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004162
untagged cDNA clones in CMV expression vector (see all 2): NM_004162

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004162

UniProtKB/Swiss-Prot: RAB5A_HUMAN, P20339

Function: Required for the fusion of plasma membranes and early endosomes

Enzyme regulation: Regulated by guanine nucleotide exchange factors (GEFs) which promote the

exchange of bound GDP for free GTP

Genatlas biochemistry entry for RAB5A:

RAB5A,Ras oncogene superfamily member,located in early endosomes

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003924	GTPase activity	TAS	2501306
GO:0005515	protein binding	NAS	14613930
GO:0005525	GTP binding	IEA	--
GO:0019001	guanyl nucleotide binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for RAB5A (Your Favorite Gene powered by Ingenuity)

Clathrin-mediated Endocytosis
Caveolar-mediated Endocytosis
Amyotrophic Lateral Sclerosis Signaling
Macropinocytosis

GeneDecks RAB5A for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for RAB5A

5/61 Interacting proteins for RAB5A (P20339^{1, 2} ENSP00000273047³) via UniProtKB, MINT, and/or STRING (see all 61 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APPL1	Q9UKG1², ENSP00000288266³	MINT-5208195 MINT-5207947 MINT-5208011 MINT-5208211 MINT-5208179 MINT-5208131 MINT-5208163 MINT-5207810 MINT-5208092 MINT-5204180 MINT-5207850 MINT-5207979 MINT-5208147 MINT-5208115 MINT-5207882 MINT-5204043 MINT-5207931 STRING (score=.991)
RIN1	Q13671¹, ENSP00000310406³	EBI-399437, EBI-366017 STRING (score=.962)
EEA1	Q15075¹^,², ENSP00000317955³	EBI-399437, EBI-298113 MINT-2883035 EBI-399437, EBI-298113 MINT-2883035 STRING (score=.999)
RAB5C	P51148¹	EBI-399437, EBI-1054923
PIK3R1 PIK3R1 (xeno)	P23727¹	EBI-399437, EBI-520244

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006897	endocytosis	TAS	8521472
GO:0007264	small GTPase mediated signal transduction	IEA	--
GO:0015031	protein transport	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for RAB5A

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RAB5A
10/15 Novoseek chemical compound relationships for RAB5A gene (see all 15 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
phosphatidylinositol 3-phosphate	76.30	7	11602609 (4), 14618335 (1), 9697774 (1), 10652369 (1)
gdp	67.38	26	15702993 (4), 8226909 (3), 18957427 (2), 9748259 (2) (see all 10)
gtp	65.05	41	17473071 (3), 8226909 (3), 14600265 (2), 8137813 (2) (see all 18)
ptdins(3)p	58.95	6	10652369 (3), 15998320 (1), 17233583 (1)
phosphatidylinositol	51.64	11	11252727 (2), 11559593 (2), 10660521 (1), 18523285 (1) (see all 8)
guanosine	37.26	1	11581220 (1)
wortmannin	36.96	12	11559593 (5), 18980614 (1), 14521088 (1)
mevalonate	34.39	1	9703948 (1)
mannose 6-phosphate	27.19	2	10821869 (1), 11404461 (1)
tyrosine	10.12	5	15152255 (2), 15601859 (1), 11062256 (1), 18723684 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RAB5A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RAB5A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004162

Sigma-Aldrich siRNA for RAB5A

Sigma-Aldrich shRNA for RAB5A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004162

REFSEQ mRNAs for RAB5A gene:

NM_004162.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004162

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004162
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004162
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004162

Additional cDNA sequence:

AF464088.1 AF498936.1 AK295992.1 AK309287.1 AK312618.1 BC001267.1 BC018288.1 CR536492.1

CR597533.1 CR625175.1 M28215.1

18 DOTS entries:

DT.417369 DT.100827317 DT.120910567 DT.95276985 DT.100827318 DT.95276987 DT.100827322 DT.120910620

DT.75170387 DT.100827325 DT.70103305 DT.95276984 DT.99928106 DT.100827323 DT.120910629 DT.120910585

DT.120910601 DT.95152330

24/264 AceView cDNA sequences (see all 264 ):

AI139501 BQ232003 AF498936 AI754665 BF512151 BE467569 Z39196 AI080727

BP377470 T27860 AW272383 BX279863 CA391029 BQ720552 AI798565 BC018288

AI421405 AI039442 BX359299 CD678338 AW130909 CR625175 BX356544 AA512889

highest scoring ESTs for RAB5A:

M28215 AA031571 AA172035 AA172287 AA219213 AA455069 AA512889 AA514846 AA521005 AA663412

Unigene Cluster for RAB5A:

RAB5A, member RAS oncogene family

Hs.475663 [show with all ESTs]

Unigene Representative Sequence: NM_004162

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RAB5A (see all 6 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8	^	9
SP1:															-		-		-
SP2:															-				-
SP3:																	-		-
SP4:															-		-
SP5:																	-		-

About this scheme

ECgene alternative splicing isoforms for RAB5A

1 Ensembl transcript including schematic representation:

ENST00000273047

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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RAB5A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RAB5A

¹ / ² / ³

6 probe-sets matching RAB5A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
600_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.79	M28215	1.00	1.00	1.00	1
36110_at²^{, 3}	U95-A	1	1.00	1.00	0.88	1.21	M28215	1.00	1.00	1.00	1
206113_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004162	0.60	1.00	0.82	1
209089_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC001267	0.80	1.00	0.91	1
206113_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209089_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTCAGAGAT

SOURCE GeneReport for Unigene cluster: Hs.475663
Expression variation in blood from EXPOLDB for RAB5A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for RAB5A gene from 5/18 species (see all 18 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RAB5A¹	--	RAB5A, member RAS oncogene family	95.35(n) 99.07(a)	404008 NM_001003317.1 NP_001003317.1
chimpanzee (Pan troglodytes)	RAB5A¹	--	RAB5A, member RAS oncogene family	99.84(n) 100(a)	460217 XM_516319.2 XP_516319.2
cow (Bos taurus)	RAB5A¹	--	RAB5A, member RAS oncogene family	91.47(n) 98.6(a)	539764 NM_001076186.1 NP_001069654.1
rat (Rattus norvegicus)	Rab5a¹	--	RAB5A, member RAS oncogene family	91.78(n) 97.67(a)	64633 NM_022692.1 NP_073183.1
mouse (Mus musculus)	Rab5a^{1, 5}	17 (32.00 cM)⁵	RAB5A, member RAS oncogene family^{1, 5}	91.47(n)¹ 98.14(a)¹	271457¹ NM_025887.3¹ NP_080163.1¹ AB232593⁵ AI663973⁵ (see all 25)

About this table Species with no ortholog for RAB5A

ENSEMBL Gene Tree for RAB5A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for RAB5A gene

RAB5C² RAB5B² RAB17²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/295 NCBI SNPs in RAB5A are shown (see all 295 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 92)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs8682^1,2	A,C,F,H	20001413(+)	`TATTGC/GAATAT`	1	--	ut3¹		7		MN EA EU WA	2094
--	rs3736124^1,2	C,F,H	20000427(+)	`ACTTAT/CGATAG`	1	--	ut3¹ ese³		8		EU EA WA	838
--	rs1049089^1,2	H	19992174(+)	`AAGAAC/GGATAC`	1	R/G	mis¹ ese³		5		MN EU EA WA	588
	rs11717172^1,2	C	19967316(+)	`CCTCCA/GGAAAG`	1	--	ut5¹ ese³ trp³		0	--	--	--	--
--	rs2229916^1,2	F,H	20000238(+)	`AATCCA/GGGAGC`	1	P/P	syn¹		0	--	--	--	--
--	rs6773437^1,2	A,C	19967436(+)	`AATACG/TGGAAA`	1	T/T	syn¹		0	--	--	--	--
	rs13078869^1,2	A,C,F,H	19974561(+)	`TTTTAC/TCTTTT`	1	--	int¹		8		EU EA WA	838
	rs11926559^1,2	A,C,F,H	19980863(+)	`TAACTC/TGTACC`	1	--	int¹		4		EU EA WA	394
	rs2127956^1,2	A,C,F,H	19984302(+)	`AATTGA/CAATGT`	1	--	int¹		4		EU EA WA	420
	rs13077307^1,2	A,C,F,H	19979646(+)	`TGTTAC/TTTCTA`	1	--	int¹		5		EU EA NA	336

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HapMap Linkage Disequilibrium images for RAB5A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 179512

4 Novoseek disease relationships for RAB5A gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
motor neuron disease	44.00	2	17239822 (1), 12837691 (1)
down syndrome	7.88	2	17611268 (1), 12890772 (1)
inflammation	5.00	1	11306580 (1)
tuberculosis	0.00	5	10768959 (4)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/196 PubMed articles for RAB5A gene (see all 196 ):

Direct interaction of EEA1 with Rab5b. (PubMed id 10491193)^{1, 3, 4} Callaghan J.M.... Stenmark H. (1999)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{3, 4} Chi A....Hunt D.F. (2006)
Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes. (PubMed id 14617813)^{3, 4} Fouraux M.A.... Pruijn G.J.M. (2004)
ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics. (PubMed id 15388334)^{3, 4} Hadano S.... Ikeda J.E. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
High resolution crystal structures of human Rab5a and five mutants with substitutions in the catalytically important phosphate-binding loop. (PubMed id 12433916)^{3, 4} Zhu G.... Zhang X.C. (2003)
Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1. (PubMed id 11703925)^{3, 4} Tall G.G.... Horazdovsky B.F. (2001)
A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion. (PubMed id 10818110)^{3, 4} Hoffenberg S.... Knoll B.J. (2000)
Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain. (PubMed id 11062261)^{3, 4} Nielsen E.... Zerial M. (2000)
Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. (PubMed id 7991565)^{3, 4} Farnsworth C.C.... Glomset J.A. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5868	HGNC: 9783	AceView: RAB5A	Ensembl:ENSG00000144566	euGenes: HUgn5868
ECgene: RAB5A	H-InvDB: RAB5A

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for RAB5A	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for RAB5A
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for RAB5A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RAB5A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RAB5A		Antibodies for RAB5A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for RAB5A		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (RAB5A)
	Antibodies (RAB5A)
	Chimera RNAi (RAB5A)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for RAB5A (Rab5)

	Recombinant Proteins (Rab5)
	Antibodies (Rab5)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

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Antibodies for RAB5A

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RAB5A Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for RAB5A

Summaries
for RAB5A

Genomic Location
for RAB5A

Proteins
for RAB5A

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Families
for RAB5A

Gene Function
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Transcripts
for RAB5A

Expression
for RAB5A

Orthologs
for RAB5A

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for RAB5A

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for RAB5A

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for RAB5A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RAB5A Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor RAB5A

Summariesfor RAB5A

Genomic Locationfor RAB5A

Proteinsfor RAB5A

Protein Domains/Familiesfor RAB5A

Gene Functionfor RAB5A

Pathways & Interactionsfor RAB5A

Drugs & Compoundsfor RAB5A

Transcriptsfor RAB5A

Expression for RAB5A

Orthologsfor RAB5A

Paralogsfor RAB5A

SNPs/Variantsfor RAB5A

Disorders & Mutationsfor RAB5A

Medical Newsfor RAB5A

Publicationsfor RAB5A

Search for RAB5A

Genome Databases showing RAB5A

Other Databases showing RAB5A

Specialized Databases showing RAB5A

Licensable Technologiesfor RAB5A

Servicesfor RAB5A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RAB5A

Summaries
for RAB5A

Genomic Location
for RAB5A

Proteins
for RAB5A

Protein Domains/
Families
for RAB5A

Gene Function
for RAB5A

Pathways & Interactions
for RAB5A

Drugs & Compounds
for RAB5A

Transcripts
for RAB5A

Expression
for RAB5A

Orthologs
for RAB5A

Paralogs
for RAB5A

SNPs/Variants
for RAB5A

Disorders & Mutations
for RAB5A

Medical News
for RAB5A

Publications
for RAB5A

Licensable Technologies
for RAB5A

Services
for RAB5A