RAB5A Gene
protein-coding GIFtS: 68
GCID: GC03P019963
|
|
RAB5A, member RAS oncogene family
(Previous symbol: RAB5)
| |
Aliases
for RAB5A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RAB5A, Member RAS Oncogene Family1 2 | | RAB51 2 3 5 | | RAS-Associated Protein RAB5A2 | | Ras-Related Protein Rab-5A2 |
Export aliases for RAB5A gene to outside databasesPrevious GC identifers: GC03P019319 GC03M019342 GC03P019838 |
Summaries
for RAB5A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RAB5A_HUMAN, P20339Function: Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodiaextension
Gene Wiki entry for RAB5A
|
Genomic Views
for RAB5A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAB5A gene promoter:
E2F-4 E2F-3a SRF E2F-5 E2F-1 E2F SRF (504 AA) E2F-2 MRF-2 GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAB5A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB5A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p24-p22 Ensembl cytogenetic band: 3p24.3 HGNC cytogenetic band: 3p24-p22RAB5A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P019963: view genomic region
(about GC identifiers)
Start:
|
19,988,571 bp from pter |
End:
|
20,026,667 bp from pter |
Size:
|
38,097 bases |
Orientation:
|
plus strand |
|
Proteins
for RAB5A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RAB5A_HUMAN, P20339 (See
protein sequence)Recommended Name: Ras-related protein Rab-5A Size: 215 amino acids; 23659 Da
Subunit: Binds EEA1. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting as a GEF. Interactswith RINL. Interacts with ALS2CL, RABEP1, SUN2, ZFYVE20 and RUFY1. Interacts with SGSM1 and SGSM3 (By similarity).Interacts with PIK3CB (By similarity)
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Early endosome membrane;Lipid-anchor (By similarity). Melanosome. Cytoplasmic vesicle (By similarity). Cell projection, ruffle (Bysimilarity). Note=Enriched in stage I melanosomes
6/12 PDB 3D structures from  and Proteopedia  for RAB5A (see all 12):1N6H (3D)
1N6I (3D)
1N6K (3D)
1N6L (3D)
1N6N (3D)
1N6O (3D)
Secondary accessions: Q6FI44Explore the universe of human proteins at neXtProt for RAB5A: NX_P20339
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P20339
RAB5A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004153.2
ENSEMBL proteins: ENSP00000273047 ENSP00000398450 ENSP00000403533 ENSP00000396632 ENSP00000411941 ENSP00000412668 Reactome Protein details: P20339
Human Recombinant Protein Products for RAB5A:
Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table
RAB5A for ontologies About GeneDecksing
RAB5A Antibody Products:
Assay Products for RAB5A: |
Protein
Domains /
Families
for RAB5A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAB5A for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P20339ProtoNet protein and cluster: P20339 1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: RAB5A_HUMAN, P20339Similarity: Belongs to the small GTPase superfamily. Rab family |
Function
for RAB5A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: RAB5A_HUMAN, P20339Function: Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodiaextensionEnzyme regulation: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP forfree GTP Genatlas biochemistry entry for RAB5A:RAB5A,Ras oncogene superfamily member,located in early endosomes
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
RAB5A for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for RAB5A:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB5A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB5A (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RAB5A (NM_004162) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAB5A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB5A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB5A |
|
Pathways & Interactions
for RAB5A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/21 super-pathways (see all 21) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Clathrin-dependent protein traffic | | | 2 | Development HGF signaling pathway | | | 3 | Normal wtCFTR traffic / Sorting endosome formation | | | 4 | Cytoskeletal Signaling | | | 5 | Factors involved in megakaryocyte development and platelet production | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for RAB5A
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RAB5A
1 
Cell Signaling Technology (CST) Pathway for RAB5A
5/6  GeneGo (Thomson Reuters) Pathways for RAB5A (see all 6)
5  BioSystems Pathways for RAB5A
2 
Reactome Pathways for RAB5A
5/6 
Kegg Pathways (Kegg details for RAB5A) (see all 6):
RAB5A for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB5A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/73 Interacting proteins for RAB5A (P203391, 2, 3 ENSP000002730474) via UniProtKB, MINT, STRING, and/or I2D (see all 73)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| APPL1 | Q9UKG12, 3, ENSP000002882664 | MINT-5208195 MINT-5207947 MINT-5208011 MINT-5208211 MINT-5208131 MINT-5208179 MINT-5207810 MINT-5208163 MINT-5208092 MINT-5204180 MINT-5207850 MINT-5207979 MINT-5208147 MINT-5208115 MINT-5207882 MINT-5204043 MINT-5207931 I2D:
score=3 STRING: ENSP00000288266 | | OCRL | Q019682, 3, ENSP000003601544 | MINT-2882933 MINT-2981030 MINT-8184901 MINT-2882874 MINT-8184712 MINT-2981062 MINT-2981094 MINT-2883194 MINT-2883167 MINT-2883115 MINT-8184913 I2D:
score=2 STRING: ENSP00000360154 | | EEA1 | Q150751, 2, 3, ENSP000003179554 | EBI-1048179,EBI-298113 MINT-2883035 I2D:
score=5 STRING: ENSP00000317955 | | ALS2 | Q96Q422, 3, ENSP000002642764 | MINT-8088056 MINT-8088071 I2D:
score=1 STRING: ENSP00000264276 | | TM9SF4 | Q925442, 3, ENSP000003811044 | MINT-7307320 MINT-7307331 I2D:
score=1 STRING: ENSP00000381104 |
About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
RAB5A for ontologies About GeneDecksing
|
Drugs & Compounds
for RAB5A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RAB5A for compounds About GeneDecksing
 Browse Tocris compounds for RAB5A
3 HMDB Compounds for RAB5A About this table
3 DrugBank Compounds for RAB5A About this table
10/19 Novoseek chemical compound relationships for RAB5A gene (see all 19) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| phosphatidylinositol 3-phosphate |
75 |
7 |
11602609 (4), 14618335 (1), 9697774 (1), 10652369 (1) |
| gdp |
66.3 |
26 |
15702993 (4), 8226909 (3), 18957427 (2), 9748259 (2) (see all 10) |
| gtp |
65.9 |
45 |
17473071 (3), 19526728 (3), 8226909 (3), 14600265 (2) (see all 20) |
| ptdins(3)p |
57.6 |
6 |
10652369 (3), 15998320 (1), 17233583 (1) |
| phosphatidylinositol |
50.3 |
11 |
11252727 (2), 11559593 (2), 10660521 (1), 18523285 (1) (see all 8) |
| guanosine |
42 |
1 |
11581220 (1) |
| wortmannin |
35.5 |
12 |
11559593 (5), 18980614 (1), 14521088 (1) |
| mevalonate |
32.7 |
1 |
9703948 (1) |
| lovastatin |
30.6 |
1 |
9703948 (1) |
| mannose 6-phosphate |
25.8 |
2 |
10821869 (1), 11404461 (1) |
Search CenterWatch for drugs/clinical trials and news about RAB5A
|
Transcripts
for RAB5A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RAB5A gene: NM_004162.4 Unigene Cluster for RAB5A: RAB5A, member RAS oncogene family Hs.475663 [show with all ESTs]Unigene Representative Sequence: NM_0041629 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000273047(uc003cbn.3 uc010hey.3 uc011awg.2) ENST00000443878
ENST00000412966 ENST00000446547 ENST00000422242 ENST00000476544 ENST00000455772
ENST00000469122 ENST00000473608
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB5A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB5A (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RAB5A (NM_004162) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAB5A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB5A |
Additional cDNA sequence: AF464088.1 AF498936.1 AK295992.1 AK309287.1 AK312618.1 BC001267.1 BC018288.1 CR536492.1 M28215.1 19 DOTS entries: DT.417369 DT.100827317 DT.120910567 DT.95276985 DT.100827318 DT.95276987 DT.100827322 DT.120910620 DT.75170387 DT.100827325 DT.70103305 DT.95276984 DT.99928106 DT.100827323 DT.120910629 DT.100827324 DT.120910585 DT.120910601 DT.95152330 24/264 AceView cDNA sequences (see all 264): CA776399 AI829352 CR597533 AI754665 AA725289 AI675286 AF498936 AA935792 BF512151 AW130909 AU133781 BC018288 AI039442 AV727867 AA878079 AW269503 AA093414 CF139079 AA512889 CR625175 BQ720552 AI421405 BX279863 Z39196
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RAB5A (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RAB5A
|
Expression
for RAB5A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RAB5A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTCAGAGAT
About this image
See RAB5A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAB5A
SOURCE GeneReport for Unigene cluster: Hs.475663
SABiosciences Custom PCR Arrays for RAB5A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB5A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAB5A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB5A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB5A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB5A |
Orthologs
for RAB5A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RAB5A gene from 8/28 species (see all 28) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RAB5A1 |
RAB5A, member RAS oncogene family |
87.91(n)
95.81(a) |
|
420649 NM_001006363.1 NP_001006363.1 |
lizard
(Anolis carolinensis) |
Reptilia |
RAB5A6 |
-- |
95(a) |
1 ↔ 1 |
6(32947222-32955794) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BC043866.12 |
-- |
77.82(n) |
|
BC043866.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
rab5aa1 |
RAB5A, member RAS oncogene family, a |
75.19(n)
93.02(a) |
|
337737 NM_201485.1 NP_958893.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
rab-51 |
Protein RAB-5 |
69.43(n)
79.02(a) |
|
172755 NM_060080.2 NP_492481.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
VPS21(YOR089C)4
VPS211 |
Rab family GTPase required for endocytic transport more4
Vps21p1 |
57.19(n)1
56.85(a)1 |
|
15(490828-490196)4
8542561, 4 NP_014732.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
RHA11 |
Ras-related protein RHA1 |
66.48(n)
68.36(a) |
|
834549 NM_123881.3 NP_199326.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.141132 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
73.81(n) |
|
AK100036.1 |
ENSEMBL Gene Tree for RAB5A (if available)
TreeFam Gene Tree for RAB5A (if available) |
Paralogs
for RAB5A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RAB5A gene
- RAB5C2 RAB202 RAB312 ENSG000002672612 RAB5B2 RAB212 RAB242 RAB22A2
- RAB172
18/92 SIMAP similar genes for RAB5A using alignment to 6 protein entries: RAB5A_HUMAN (see all proteins)
(see all similar genes):RAB5C RAB5B rab1b DKFZp686J06205 RAB11A RAB17
RAB22A RAB15 RAB2B RAB31 RAB6A RAB39B
RAB30 RAB6B DKFZp313C1541 RAB2A RAB1C RAB41
RAB5A for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for RAB5A
PGOHUM00000239301 PGOHUM00000243217 PGOHUM00000250210
|
Genomic Variants
for RAB5A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RAB5A (19988571 - 20026667 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for RAB5A
3 CNVs: 37530 63413 8415
2 Indels: 27286 29526 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB5A |
|
Disorders
/ Diseases
for RAB5A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RAB5A for disorders About GeneDecksing
OMIM gene information: 179512
OMIM disorders: --
20/31  diseases for RAB5A (see all 31): About MalaCardsvenezuelan equine encephalitis amyotrophic lateral sclerosis (als) west nile virus amyotrophic lateral sclerosis
lateral sclerosis motor neuron disease multiple system atrophy borna disease
choroideremia tuberous sclerosis down syndrome encephalitis
alzheimer's disease hepatitis c huntington's disease hepatocellular carcinoma
ovarian cancer tuberculosis prostate cancer breast cancer
5 Novoseek disease relationships for RAB5A gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| motor neuron disease |
42.4 |
2 |
17239822 (1), 12837691 (1) |
| down syndrome |
6.21 |
2 |
17611268 (1), 12890772 (1) |
| inflammation |
4.48 |
1 |
11306580 (1) |
| alzheimers disease |
2.07 |
1 |
19526546 (1) |
| tuberculosis |
0 |
5 |
10768959 (4) |
Human Genome Epidemiology (HuGE) Navigator: RAB5A (3 documents)
Export disorders for RAB5A gene to outside databases
|
Publications
for RAB5A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RAB5A gene, integrated from 9 sources (see all 268):
(articles sorted by number of sources associating them with RAB5A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Direct interaction of EEA1 with Rab5b. (PubMed id 10491193)1, 2, 9 Callaghan J.M.... Stenmark H. (1999)
- Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
- Structural basis of family-wide Rab GTPase recognition by rabenosyn- 5. (PubMed id 16034420)1, 2 Eathiraj S.... Lambright D.G. (2005)
- ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics. (PubMed id 15388334)1, 2 Hadano S.... Ikeda J.-E. (2004)
- Structural basis of Rab5-Rabaptin5 interaction in endocytosis. (PubMed id 15378032)1, 2 Zhu G.... Zhang X.C. (2004)
- Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. (PubMed id 14978216)1, 2 Gauthier-Campbell C....El-Husseini A.e.l.-.D. (2004)
- Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes. (PubMed id 14617813)1, 2 Fouraux M.A.... Pruijn G.J.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- High resolution crystal structures of human Rab5a and five mutants with substitutions in the catalytically important phosphate-binding loop. (PubMed id 12433916)1, 2 Zhu G.... Zhang X.C. (2003)
- Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1. (PubMed id 11703925)1, 2 Tall G.G.... Horazdovsky B.F. (2001)
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External Searches for RAB5A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing RAB5A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing RAB5A gene
(According to HUGE)
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Specialized Databases showing RAB5A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for RAB5A gene:
Search GeneIP for patents involving RAB5A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RAB5A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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