Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RAB4B-EGLN2 Gene

Subcategory (RNA class) for RAB4B-EGLN2 Gene

ncRNA

Quality Score for this RNA gene is

3

Aliases for RAB4B-EGLN2 Gene

  • RAB4B-EGLN2 Readthrough (NMD Candidate) 2 3 5
  • RAB4B-EGLN2 Readthrough Long Non-Coding RNA 2 3
  • RAB4B-EGLN2 Readthrough (Non-Protein Coding) 3
  • RERT-LncRNA 3

External Ids for RAB4B-EGLN2 Gene

Previous GeneCards Identifiers for RAB4B-EGLN2 Gene

  • GC19U901528
  • GC19P041307
  • GC19P041286
  • GC19P041288

Summaries for RAB4B-EGLN2 Gene

Entrez Gene Summary for RAB4B-EGLN2 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring RAB4B (RAB4B, member RAS oncogene family) and EGLN2 (egl nine homolog 2) genes on chromosome 19. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Feb 2011]

GeneCards Summary for RAB4B-EGLN2 Gene

RAB4B-EGLN2 (RAB4B-EGLN2 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB4B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB4B-EGLN2 Gene

Genomics for RAB4B-EGLN2 Gene

Regulatory Elements for RAB4B-EGLN2 Gene

Enhancers for RAB4B-EGLN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F040747 0.9 FANTOM5 ENCODE 12.1 -25.5 -25458 9.8 MLX CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF263 SNRPA FBL ENSG00000269843 COQ8B ITPKC CCDC97 SERTAD3 ENSG00000269069 CYP2G2P ENSG00000271299
GH19F040662 0.9 Ensembl ENCODE 11.3 -114.5 -114473 2.8 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SNRPA FBL CCDC97 ITPKC NUMBL ENSG00000269843 ENSG00000269069 RAB4B C19orf54 RNU6-195P
GH19F040665 1 Ensembl ENCODE 11.1 -111.7 -111733 1.7 SIN3A GATA2 FOS YY2 JUNB ZNF264 MBD2 MAFF ZNF658 SMARCA4 SNRPA FBL CCDC97 C19orf54 ITPKC RNU6-195P CYP2F2P RAB4B RAB4B-EGLN2 EGLN2
GH19F040612 0.4 ENCODE 10.7 -163.7 -163737 4.0 HDGF ATF1 PKNOX1 ARNT SIN3A ZNF121 ZNF207 FOS KLF7 SP3 SNRPA SERTAD3 ENSG00000269843 SHKBP1 NUMBL ITPKC FBL RAB4B RAB4B-EGLN2 EGLN2
GH19F040783 0.3 FANTOM5 0.4 +5.0 5034 0.2 ZNF362 ZNF366 PRDM10 SHKBP1 EGLN2 COQ8B RAB4B SERTAD3 RAB4B-EGLN2 ENSG00000282951
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RAB4B-EGLN2 on UCSC Golden Path with GeneCards custom track

Promoters for RAB4B-EGLN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000641660 -19 2001 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF207 ZNF143

Genomic Location for RAB4B-EGLN2 Gene

Chromosome:
19
Start:
40,778,219 bp from pter
End:
40,808,441 bp from pter
Size:
30,223 bases
Orientation:
Plus strand

Genomic View for RAB4B-EGLN2 Gene

Genes around RAB4B-EGLN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB4B-EGLN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB4B-EGLN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB4B-EGLN2 Gene

Proteins for RAB4B-EGLN2 Gene

  • Protein details for RAB4B-EGLN2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A024R0K8
    Recommended name:
    HCG1995540, isoform CRA_c
    Protein Accession:
    A0A024R0K8

    Protein attributes for RAB4B-EGLN2 Gene

    Size:
    213 amino acids
    Molecular mass:
    23587 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RAB4B-EGLN2 Gene

Post-translational modifications for RAB4B-EGLN2 Gene

No Post-translational modifications

Other Protein References for RAB4B-EGLN2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for RAB4B-EGLN2 Gene

Domains & Families for RAB4B-EGLN2 Gene

Protein Domains for RAB4B-EGLN2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RAB4B-EGLN2: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RAB4B-EGLN2 Gene

Function for RAB4B-EGLN2 Gene

Phenotypes for RAB4B-EGLN2 Gene

GenomeRNAi human phenotypes for RAB4B-EGLN2:
genes like me logo Genes that share phenotypes with RAB4B-EGLN2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RAB4B-EGLN2 Gene

Localization for RAB4B-EGLN2 Gene

Gene Ontology (GO) - Cellular Components for RAB4B-EGLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with RAB4B-EGLN2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for RAB4B-EGLN2 Gene

Pathways & Interactions for RAB4B-EGLN2 Gene

SuperPathways for RAB4B-EGLN2 Gene

No Data Available

Interacting Proteins for RAB4B-EGLN2 Gene

Gene Ontology (GO) - Biological Process for RAB4B-EGLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with RAB4B-EGLN2: view

No data available for Pathways by source and SIGNOR curated interactions for RAB4B-EGLN2 Gene

Transcripts for RAB4B-EGLN2 Gene

mRNA/cDNA for RAB4B-EGLN2 Gene

(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RAB4B-EGLN2 Gene

No ASD Table

Relevant External Links for RAB4B-EGLN2 Gene

GeneLoc Exon Structure for
RAB4B-EGLN2
ECgene alternative splicing isoforms for
RAB4B-EGLN2

Expression for RAB4B-EGLN2 Gene

mRNA expression in normal human tissues for RAB4B-EGLN2 Gene

genes like me logo Genes that share expression patterns with RAB4B-EGLN2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RAB4B-EGLN2 Gene

Orthologs for RAB4B-EGLN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB4B-EGLN2 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Rab4b 35
  • 100 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RAB4B 35
  • 100 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 91 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RAB4B 35
  • 89 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 77 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 92 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii rab4b 35
  • 92 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Rab4 35
  • 77 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 69 (a)
OneToMany
Species where no ortholog for RAB4B-EGLN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB4B-EGLN2 Gene

ENSEMBL:
Gene Tree for RAB4B-EGLN2 (if available)
TreeFam:
Gene Tree for RAB4B-EGLN2 (if available)

Paralogs for RAB4B-EGLN2 Gene

Paralogs for RAB4B-EGLN2 Gene

genes like me logo Genes that share paralogs with RAB4B-EGLN2: view

Variants for RAB4B-EGLN2 Gene

Sequence variations from dbSNP and Humsavar for RAB4B-EGLN2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10402460 -- 40,798,993(+) CGGGG(C/G)GGAGG intron-variant, upstream-variant-2KB
rs10403040 -- 40,790,141(+) cagga(A/T)cagat intron-variant
rs10404398 -- 40,785,475(+) cactg(C/T)actcc intron-variant
rs10404764 -- 40,785,474(+) ccact(A/G)cactc intron-variant
rs10405596 -- 40,808,815(+) CATTG(C/T)CCTGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RAB4B-EGLN2 Gene

Variant ID Type Subtype PubMed ID
esv26234 CNV loss 19812545
esv2758762 CNV gain+loss 17122850
nsv1066637 CNV gain 25217958
nsv1118831 CNV deletion 24896259
nsv521459 CNV loss 19592680
nsv833832 CNV loss 17160897

Relevant External Links for RAB4B-EGLN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB4B-EGLN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for RAB4B-EGLN2 Gene

Disorders for RAB4B-EGLN2 Gene

Relevant External Links for RAB4B-EGLN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB4B-EGLN2

No disorders were found for RAB4B-EGLN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB4B-EGLN2 Gene

Publications for RAB4B-EGLN2 Gene

  1. An insertion/deletion polymorphism within RERT-lncRNA modulates hepatocellular carcinoma risk. (PMID: 23026137) Zhu Z. … Gao Y. (Cancer Res. 2012) 2 3 64
  2. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. (PMID: 22080838) Cho M.H. … . (Hum. Mol. Genet. 2012) 3 64
  3. Genome-wide meta-analyses identify multiple loci associated with smoking behavior. (PMID: 20418890) (Nat. Genet. 2010) 3 64
  4. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64

Products for RAB4B-EGLN2 Gene

Sources for RAB4B-EGLN2 Gene

Content
Loading form....