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Aliases for RAB4B-EGLN2 Gene

Subcategory (RNA class) for RAB4B-EGLN2 Gene


Quality Score for this RNA gene is


Aliases for RAB4B-EGLN2 Gene

  • RAB4B-EGLN2 Readthrough (NMD Candidate) 2 3 5
  • RAB4B-EGLN2 Readthrough Long Non-Coding RNA 2 3
  • RAB4B-EGLN2 Readthrough (Non-Protein Coding) 3
  • RERT-LncRNA 3

External Ids for RAB4B-EGLN2 Gene

Previous GeneCards Identifiers for RAB4B-EGLN2 Gene

  • GC19U901528
  • GC19P041307
  • GC19P041286
  • GC19P041288

Summaries for RAB4B-EGLN2 Gene

Entrez Gene Summary for RAB4B-EGLN2 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring RAB4B (RAB4B, member RAS oncogene family) and EGLN2 (egl nine homolog 2) genes on chromosome 19. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Feb 2011]

GeneCards Summary for RAB4B-EGLN2 Gene

RAB4B-EGLN2 (RAB4B-EGLN2 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB4B.

Additional gene information for RAB4B-EGLN2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB4B-EGLN2 Gene

Genomics for RAB4B-EGLN2 Gene

Regulatory Elements for RAB4B-EGLN2 Gene

Enhancers for RAB4B-EGLN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H040747 1.8 FANTOM5 ENCODE dbSUPER 12.2 -25.5 -25458 9.8 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 ZNF416 ZNF143 SP3 NFYC HNRNPUL1 SNRPA ENSG00000269843 CCDC97 COQ8B ZNF780A AKT2 ZNF780B ITPKC FBL
GH19H040662 1.4 Ensembl ENCODE 11.3 -114.5 -114473 2.8 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 CBX5 SNRPA HNRNPUL1 ENSG00000269843 FBL ITPKC CCDC97 AKT2 ZNF780A RAB4B C19orf54
GH19H040665 1.3 Ensembl ENCODE 11.1 -111.7 -111733 1.7 ATF1 ARNT SIN3A TCF12 GATA2 FOS ATF7 YY2 NCOA1 ZNF592 C19orf54 RNU6-195P ZNF546 CYP2G1P RAB4B RAB4B-EGLN2 SNRPA EGLN2 ZNF780B COQ8B
GH19H040791 0.9 ENCODE dbSUPER 0.4 +14.4 14394 2.3 GATAD2A SCRT1 HLF CEBPB CEBPG ZNF623 ZNF157 ZNF366 RBAK PRDM12 EGLN2 CYP2T1P COQ8B ENSG00000282951 RAB4B-EGLN2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAB4B-EGLN2 on UCSC Golden Path with GeneCards custom track

Promoters for RAB4B-EGLN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109587 -119 1801 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF207 ZNF143

Genomic Locations for RAB4B-EGLN2 Gene

Genomic Locations for RAB4B-EGLN2 Gene
30,223 bases
Plus strand

Genomic View for RAB4B-EGLN2 Gene

Genes around RAB4B-EGLN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB4B-EGLN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB4B-EGLN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB4B-EGLN2 Gene

Proteins for RAB4B-EGLN2 Gene

  • Protein details for RAB4B-EGLN2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    HCG1995540, isoform CRA_c
    Protein Accession:

    Protein attributes for RAB4B-EGLN2 Gene

    213 amino acids
    Molecular mass:
    23587 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RAB4B-EGLN2 Gene

Post-translational modifications for RAB4B-EGLN2 Gene

No Post-translational modifications

Other Protein References for RAB4B-EGLN2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for RAB4B-EGLN2 Gene

Domains & Families for RAB4B-EGLN2 Gene

Protein Domains for RAB4B-EGLN2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RAB4B-EGLN2: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RAB4B-EGLN2 Gene

Function for RAB4B-EGLN2 Gene

Phenotypes From GWAS Catalog for RAB4B-EGLN2 Gene

Gene Ontology (GO) - Molecular Function for RAB4B-EGLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB4B-EGLN2: view

Phenotypes for RAB4B-EGLN2 Gene

GenomeRNAi human phenotypes for RAB4B-EGLN2:
genes like me logo Genes that share phenotypes with RAB4B-EGLN2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RAB4B-EGLN2 Gene

Localization for RAB4B-EGLN2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB4B-EGLN2 gene
Compartment Confidence
endosome 5
plasma membrane 4
nucleus 3
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for RAB4B-EGLN2 Gene

Pathways & Interactions for RAB4B-EGLN2 Gene

SuperPathways for RAB4B-EGLN2 Gene

No Data Available

Interacting Proteins for RAB4B-EGLN2 Gene

Gene Ontology (GO) - Biological Process for RAB4B-EGLN2 Gene


No data available for Pathways by source and SIGNOR curated interactions for RAB4B-EGLN2 Gene

Drugs & Compounds for RAB4B-EGLN2 Gene

No Compound Related Data Available

Transcripts for RAB4B-EGLN2 Gene

mRNA/cDNA for RAB4B-EGLN2 Gene

(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RAB4B-EGLN2 Gene

No ASD Table

Relevant External Links for RAB4B-EGLN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB4B-EGLN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB4B-EGLN2 Gene

Evidence on tissue expression from TISSUES for RAB4B-EGLN2 Gene

  • Nervous system(4.8)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with RAB4B-EGLN2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB4B-EGLN2 Gene

Orthologs for RAB4B-EGLN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB4B-EGLN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Rab4b 34
  • 100 (a)
(Pan troglodytes)
Mammalia RAB4B 34
  • 100 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 91 (a)
(Canis familiaris)
Mammalia RAB4B 34
  • 89 (a)
(Bos Taurus)
Mammalia -- 34
  • 77 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 92 (a)
(Danio rerio)
Actinopterygii rab4b 34
  • 92 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab4 34
  • 77 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 69 (a)
Species where no ortholog for RAB4B-EGLN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB4B-EGLN2 Gene

Gene Tree for RAB4B-EGLN2 (if available)
Gene Tree for RAB4B-EGLN2 (if available)

Paralogs for RAB4B-EGLN2 Gene

Paralogs for RAB4B-EGLN2 Gene

genes like me logo Genes that share paralogs with RAB4B-EGLN2: view

Variants for RAB4B-EGLN2 Gene

Sequence variations from dbSNP and Humsavar for RAB4B-EGLN2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000058022 -- 40,800,666(+) GCCGG(A/G)CCAGG nc-transcript-variant, reference, missense
rs1000126726 -- 40,795,782(+) AGCTC(A/T)CCGTA intron-variant
rs1000181343 -- 40,804,791(+) GCCCC(C/T)TCCTG intron-variant
rs1000215381 -- 40,785,366(+) AAAGC(C/G)TGGGT intron-variant
rs1000260619 -- 40,801,208(+) GAGGC(C/T)CTCAA nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for RAB4B-EGLN2 Gene

Variant ID Type Subtype PubMed ID
nsv521459 CNV loss 19592680
nsv833832 CNV loss 17160897
nsv1118831 CNV deletion 24896259
nsv1066637 CNV gain 25217958
esv2758762 CNV gain+loss 17122850
esv26234 CNV loss 19812545

Relevant External Links for RAB4B-EGLN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for RAB4B-EGLN2 Gene

Disorders for RAB4B-EGLN2 Gene

Relevant External Links for RAB4B-EGLN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RAB4B-EGLN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB4B-EGLN2 Gene

Publications for RAB4B-EGLN2 Gene

  1. An insertion/deletion polymorphism within RERT-lncRNA modulates hepatocellular carcinoma risk. (PMID: 23026137) Zhu Z … Gao Y (Cancer research 2012) 2 3 60
  2. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. (PMID: 22080838) Cho MH … COPDGene Investigators (Human molecular genetics 2012) 3 60
  3. Genome-wide meta-analyses identify multiple loci associated with smoking behavior. (PMID: 20418890) Tobacco and Genetics Consortium (Nature genetics 2010) 3 60
  4. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 60

Products for RAB4B-EGLN2 Gene

Sources for RAB4B-EGLN2 Gene

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