Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RAB4B Gene

Aliases for RAB4B Gene

  • RAB4B, Member RAS Oncogene Family 2 3
  • Ras-Related GTP-Binding Protein 4b 2
  • Small GTP Binding Protein RAB4B 2

External Ids for RAB4B Gene

Previous GeneCards Identifiers for RAB4B Gene

  • GC19P041923
  • GC19P041675
  • GC19P045960
  • GC19P045974
  • GC19P045977
  • GC19P045979
  • GC19P041284
  • GC19P037717

Summaries for RAB4B Gene

Entrez Gene Summary for RAB4B Gene

  • RAB proteins, such as RAB4B, are members of the RAS superfamily of small GTPases that are involved in vesicular trafficking (He et al., 2002 [PubMed 12450215]).[supplied by OMIM, Aug 2009]

GeneCards Summary for RAB4B Gene

RAB4B (RAB4B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Delta508-CFTR traffic / ER-to-Golgi in CF. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB42.

UniProtKB/Swiss-Prot for RAB4B Gene

  • Protein transport. Probably involved in vesicular traffic (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB4B Gene

Genomics for RAB4B Gene

Regulatory Elements for RAB4B Gene

Genomic Location for RAB4B Gene

40,778,216 bp from pter
40,796,944 bp from pter
18,729 bases
Plus strand

Genomic View for RAB4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB4B Gene

Proteins for RAB4B Gene

  • Protein details for RAB4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-4B
    Protein Accession:
    Secondary Accessions:
    • P22750
    • Q7Z514
    • Q9HBR6

    Protein attributes for RAB4B Gene

    213 amino acids
    Molecular mass:
    23587 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RAB4B Gene

    Alternative splice isoforms for RAB4B Gene


neXtProt entry for RAB4B Gene

Proteomics data for RAB4B Gene at MOPED

Post-translational modifications for RAB4B Gene

  • Ubiquitination at Lys58
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB4B Gene

No data available for DME Specific Peptides for RAB4B Gene

Domains for RAB4B Gene

Gene Families for RAB4B Gene

  • RAB :RAB, member RAS oncogene

Suggested Antigen Peptide Sequences for RAB4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P61018
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB4B: view

Function for RAB4B Gene

Molecular function for RAB4B Gene

UniProtKB/Swiss-Prot Function: Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Ontology (GO) - Molecular Function for RAB4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003924 GTPase activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB4B: view

Animal Model Products

CRISPR Products

miRNA for RAB4B Gene

miRTarBase miRNAs that target RAB4B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB4B

Clone Products

  • Addgene plasmids for RAB4B
  • Addgene plasmids for RAB4B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB4B Gene

Localization for RAB4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB4B Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for RAB4B Gene COMPARTMENTS Subcellular localization image for RAB4B gene
Compartment Confidence
plasma membrane 5
cytosol 3
mitochondrion 2
endosome 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RAB4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with RAB4B: view

Pathways for RAB4B Gene

genes like me logo Genes that share pathways with RAB4B: view

Gene Ontology (GO) - Biological Process for RAB4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction --
genes like me logo Genes that share ontologies with RAB4B: view

Transcripts for RAB4B Gene

Unigene Clusters for RAB4B Gene

RAB4B, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB4B

Clone Products

  • Addgene plasmids for RAB4B
  • Addgene plasmids for RAB4B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB4B Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1: - - -
SP2: -
SP3: - -

Relevant External Links for RAB4B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB4B Gene

mRNA expression in normal human tissues for RAB4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB4B Gene

This gene is overexpressed in Whole Blood (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB4B Gene

SOURCE GeneReport for Unigene cluster for RAB4B Gene Hs.631539

genes like me logo Genes that share expressions with RAB4B: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RAB4B Gene

Orthologs for RAB4B Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB4B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAB4B 36
  • 100 (a)
(Bos Taurus)
Mammalia -- 36
  • 77 (a)
RAB4B 35
  • 92.8 (n)
  • 100 (a)
(Canis familiaris)
Mammalia RAB4B 35
  • 94.37 (n)
  • 100 (a)
RAB4B 36
  • 89 (a)
(Mus musculus)
Mammalia Rab4b 35
  • 91.55 (n)
  • 99.53 (a)
Rab4b 16
Rab4b 36
  • 100 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
(Rattus norvegicus)
Mammalia Rab4b 35
  • 91.86 (n)
  • 99.53 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab4b 35
  • 72.61 (n)
  • 86.38 (a)
(Danio rerio)
Actinopterygii rab4b 35
  • 79.03 (n)
  • 91.08 (a)
rab4b 36
  • 92 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004204 35
  • 71.12 (n)
  • 79.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab4 35
  • 67.93 (n)
  • 78.2 (a)
Rab4 36
  • 77 (a)
Rab4 37
  • 75 (a)
Rab-RP4 37
  • 45 (a)
(Caenorhabditis elegans)
Secernentea F11A5.4 37
  • 52 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13157 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
Species with no ortholog for RAB4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB4B Gene

Gene Tree for RAB4B (if available)
Gene Tree for RAB4B (if available)

Paralogs for RAB4B Gene

genes like me logo Genes that share paralogs with RAB4B: view

Variants for RAB4B Gene

Structural Variations from Database of Genomic Variants (DGV) for RAB4B Gene

Variant ID Type Subtype PubMed ID
nsv833832 CNV Loss 17160897
esv26234 CNV Loss 19812545
dgv1084e1 CNV Complex 17122850

Relevant External Links for RAB4B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RAB4B Gene

Disorders for RAB4B Gene

Relevant External Links for RAB4B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RAB4B: view

No data available for UniProtKB/Swiss-Prot for RAB4B Gene

Publications for RAB4B Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  2. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. (PMID: 22080838) Cho M.H. … . (Hum. Mol. Genet. 2012) 3 48
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for RAB4B Gene

Sources for RAB4B Gene

Back to Top