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Aliases for RAB4B Gene

Aliases for RAB4B Gene

  • RAB4B, Member RAS Oncogene Family 2 3 5
  • Ras-Related GTP-Binding Protein 4b 2
  • Small GTP Binding Protein RAB4B 2

External Ids for RAB4B Gene

Previous GeneCards Identifiers for RAB4B Gene

  • GC19P041923
  • GC19P041675
  • GC19P045960
  • GC19P045974
  • GC19P045977
  • GC19P045979
  • GC19P041284
  • GC19P037717

Summaries for RAB4B Gene

Entrez Gene Summary for RAB4B Gene

  • RAB proteins, such as RAB4B, are members of the RAS superfamily of small GTPases that are involved in vesicular trafficking (He et al., 2002 [PubMed 12450215]).[supplied by OMIM, Aug 2009]

GeneCards Summary for RAB4B Gene

RAB4B (RAB4B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Immune System and Endocytic Trafficking of EGFR. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB4B-EGLN2.

UniProtKB/Swiss-Prot for RAB4B Gene

  • Protein transport. Probably involved in vesicular traffic (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB4B Gene

Genomics for RAB4B Gene

Regulatory Elements for RAB4B Gene

Enhancers for RAB4B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F040662 1.4 Ensembl ENCODE 17.3 -114.5 -114470 2.8 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SNRPA FBL CCDC97 ITPKC NUMBL ENSG00000269843 ENSG00000269069 RAB4B C19orf54 RNU6-195P
GH19F040747 1.6 FANTOM5 ENCODE 12.1 -25.5 -25455 9.8 MLX CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF263 SNRPA FBL ENSG00000269843 COQ8B ITPKC CCDC97 SERTAD3 ENSG00000269069 CYP2G2P ENSG00000271299
GH19F040665 1.2 Ensembl ENCODE 11.1 -111.7 -111730 1.7 SIN3A GATA2 FOS YY2 JUNB ZNF264 MBD2 MAFF ZNF658 SMARCA4 SNRPA FBL CCDC97 C19orf54 ITPKC RNU6-195P CYP2F2P RAB4B RAB4B-EGLN2 EGLN2
GH19F040612 1 ENCODE 10.7 -163.7 -163734 4.0 HDGF ATF1 PKNOX1 ARNT SIN3A ZNF121 ZNF207 FOS KLF7 SP3 SNRPA SERTAD3 ENSG00000269843 SHKBP1 NUMBL ITPKC FBL RAB4B RAB4B-EGLN2 EGLN2
GH19F040774 0.8 Ensembl ENCODE 5.7 -2.9 -2897 1.4 ZNF664 ZFHX2 IKZF1 ZMYM3 C19orf54 MIA SNRPA RNU6-195P ITPKC RAB4B MIA-RAB4B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAB4B on UCSC Golden Path with GeneCards custom track

Promoters for RAB4B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000641660 -16 2001 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF207 ZNF143

Genomic Location for RAB4B Gene

Chromosome:
19
Start:
40,778,216 bp from pter
End:
40,796,944 bp from pter
Size:
18,729 bases
Orientation:
Plus strand

Genomic View for RAB4B Gene

Genes around RAB4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB4B Gene

Proteins for RAB4B Gene

  • Protein details for RAB4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61018-RAB4B_HUMAN
    Recommended name:
    Ras-related protein Rab-4B
    Protein Accession:
    P61018
    Secondary Accessions:
    • P22750
    • Q7Z514
    • Q9HBR6

    Protein attributes for RAB4B Gene

    Size:
    213 amino acids
    Molecular mass:
    23587 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RAB4B Gene

    Alternative splice isoforms for RAB4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB4B Gene

Post-translational modifications for RAB4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB4B Gene

No data available for DME Specific Peptides for RAB4B Gene

Domains & Families for RAB4B Gene

Gene Families for RAB4B Gene

Suggested Antigen Peptide Sequences for RAB4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61018

UniProtKB/Swiss-Prot:

RAB4B_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB4B: view

Function for RAB4B Gene

Molecular function for RAB4B Gene

UniProtKB/Swiss-Prot Function:
Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Ontology (GO) - Molecular Function for RAB4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB4B: view
genes like me logo Genes that share phenotypes with RAB4B: view

Animal Model Products

miRNA for RAB4B Gene

miRTarBase miRNAs that target RAB4B

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAB4B
  • Addgene plasmids for RAB4B

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB4B Gene

Localization for RAB4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB4B Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB4B gene
Compartment Confidence
endosome 5
plasma membrane 4
cytosol 3
mitochondrion 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RAB4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0032593 insulin-responsive compartment IDA 19590752
GO:0048471 perinuclear region of cytoplasm IDA 19590752
genes like me logo Genes that share ontologies with RAB4B: view

Pathways & Interactions for RAB4B Gene

genes like me logo Genes that share pathways with RAB4B: view

Gene Ontology (GO) - Biological Process for RAB4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
GO:0030100 regulation of endocytosis IBA --
GO:0046323 glucose import IMP 19590752
genes like me logo Genes that share ontologies with RAB4B: view

No data available for SIGNOR curated interactions for RAB4B Gene

Transcripts for RAB4B Gene

Unigene Clusters for RAB4B Gene

RAB4B, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAB4B
  • Addgene plasmids for RAB4B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB4B Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1: - - -
SP2: -
SP3: - -
SP4:

Relevant External Links for RAB4B Gene

GeneLoc Exon Structure for
RAB4B
ECgene alternative splicing isoforms for
RAB4B

Expression for RAB4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAB4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB4B Gene

This gene is overexpressed in Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for RAB4B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.8) and Brain (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB4B Gene



Protein tissue co-expression partners for RAB4B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAB4B Gene:

RAB4B

SOURCE GeneReport for Unigene cluster for RAB4B Gene:

Hs.631539
genes like me logo Genes that share expression patterns with RAB4B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RAB4B Gene

Orthologs for RAB4B Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB4B 35
  • 100 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RAB4B 34 35
  • 94.37 (n)
cow
(Bos Taurus)
Mammalia RAB4B 34
  • 92.8 (n)
-- 35
  • 77 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rab4b 34
  • 91.86 (n)
mouse
(Mus musculus)
Mammalia Rab4b 34 16 35
  • 91.55 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 91 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 92 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rab4b 34
  • 72.61 (n)
zebrafish
(Danio rerio)
Actinopterygii rab4b 34 35
  • 79.03 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004204 34
  • 71.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rab4 36 34 35
  • 67.93 (n)
Rab-RP4 36
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea F11A5.4 36
  • 52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 69 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13157 34
Species where no ortholog for RAB4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB4B Gene

ENSEMBL:
Gene Tree for RAB4B (if available)
TreeFam:
Gene Tree for RAB4B (if available)

Paralogs for RAB4B Gene

genes like me logo Genes that share paralogs with RAB4B: view

Variants for RAB4B Gene

Sequence variations from dbSNP and Humsavar for RAB4B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10403040 -- 40,790,141(+) cagga(A/T)cagat intron-variant
rs10404398 -- 40,785,475(+) cactg(C/T)actcc intron-variant
rs10404764 -- 40,785,474(+) ccact(A/G)cactc intron-variant
rs10405633 -- 40,785,798(+) TTCAT(A/G)GAGCT intron-variant
rs10405949 -- 40,785,410(+) ggagg(C/T)tgagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB4B Gene

Variant ID Type Subtype PubMed ID
esv26234 CNV loss 19812545
esv2758762 CNV gain+loss 17122850
nsv833832 CNV loss 17160897

Variation tolerance for RAB4B Gene

Residual Variation Intolerance Score: 31.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.10; 2.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB4B Gene

Disorders for RAB4B Gene

Relevant External Links for RAB4B

Genetic Association Database (GAD)
RAB4B
Human Genome Epidemiology (HuGE) Navigator
RAB4B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB4B

No disorders were found for RAB4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB4B Gene

Publications for RAB4B Gene

  1. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. (PMID: 22080838) Cho M.H. … . (Hum. Mol. Genet. 2012) 3 46 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  5. Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. (PMID: 26354767) Bailey M.L. … Hieter P. (Genetics 2015) 3 64

Products for RAB4B Gene

Sources for RAB4B Gene

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