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Aliases for RAB4B Gene

Aliases for RAB4B Gene

  • RAB4B, Member RAS Oncogene Family 2 3
  • Ras-Related GTP-Binding Protein 4b 2
  • Small GTP Binding Protein RAB4B 2

External Ids for RAB4B Gene

Previous GeneCards Identifiers for RAB4B Gene

  • GC19P041923
  • GC19P041675
  • GC19P045960
  • GC19P045974
  • GC19P045977
  • GC19P045979
  • GC19P041284
  • GC19P037717

Summaries for RAB4B Gene

Entrez Gene Summary for RAB4B Gene

  • RAB proteins, such as RAB4B, are members of the RAS superfamily of small GTPases that are involved in vesicular trafficking (He et al., 2002 [PubMed 12450215]).[supplied by OMIM, Aug 2009]

GeneCards Summary for RAB4B Gene

RAB4B (RAB4B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF). GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB42.

UniProtKB/Swiss-Prot for RAB4B Gene

  • Protein transport. Probably involved in vesicular traffic (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB4B Gene

Genomics for RAB4B Gene

Regulatory Elements for RAB4B Gene

Genomic Location for RAB4B Gene

Chromosome:
19
Start:
40,778,216 bp from pter
End:
40,796,944 bp from pter
Size:
18,729 bases
Orientation:
Plus strand

Genomic View for RAB4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB4B Gene

Proteins for RAB4B Gene

  • Protein details for RAB4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61018-RAB4B_HUMAN
    Recommended name:
    Ras-related protein Rab-4B
    Protein Accession:
    P61018
    Secondary Accessions:
    • P22750
    • Q7Z514
    • Q9HBR6

    Protein attributes for RAB4B Gene

    Size:
    213 amino acids
    Molecular mass:
    23587 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RAB4B Gene

    Alternative splice isoforms for RAB4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB4B Gene

Proteomics data for RAB4B Gene at MOPED

Post-translational modifications for RAB4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB4B Gene

No data available for DME Specific Peptides for RAB4B Gene

Domains & Families for RAB4B Gene

Gene Families for RAB4B Gene

Suggested Antigen Peptide Sequences for RAB4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61018

UniProtKB/Swiss-Prot:

RAB4B_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB4B: view

Function for RAB4B Gene

Molecular function for RAB4B Gene

UniProtKB/Swiss-Prot Function:
Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Ontology (GO) - Molecular Function for RAB4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003924 GTPase activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB4B: view
genes like me logo Genes that share phenotypes with RAB4B: view

Animal Model Products

miRNA for RAB4B Gene

miRTarBase miRNAs that target RAB4B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB4B

Clone Products

  • Addgene plasmids for RAB4B
  • Addgene plasmids for RAB4B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB4B Gene

Localization for RAB4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB4B Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB4B Gene COMPARTMENTS Subcellular localization image for RAB4B gene
Compartment Confidence
endosome 5
plasma membrane 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RAB4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0032593 insulin-responsive compartment IDA 19590752
GO:0048471 perinuclear region of cytoplasm IDA 19590752
genes like me logo Genes that share ontologies with RAB4B: view

Pathways & Interactions for RAB4B Gene

genes like me logo Genes that share pathways with RAB4B: view

Gene Ontology (GO) - Biological Process for RAB4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction --
GO:0015031 protein transport --
genes like me logo Genes that share ontologies with RAB4B: view

No data available for SIGNOR curated interactions for RAB4B Gene

Drugs & Compounds for RAB4B Gene

No Compound Related Data Available

Transcripts for RAB4B Gene

Unigene Clusters for RAB4B Gene

RAB4B, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB4B

Clone Products

  • Addgene plasmids for RAB4B
  • Addgene plasmids for RAB4B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB4B Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1: - - -
SP2: -
SP3: - -
SP4:

Relevant External Links for RAB4B Gene

GeneLoc Exon Structure for
RAB4B
ECgene alternative splicing isoforms for
RAB4B

Expression for RAB4B Gene

mRNA expression in normal human tissues for RAB4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB4B Gene

This gene is overexpressed in Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for RAB4B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.8) and Brain (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB4B Gene



SOURCE GeneReport for Unigene cluster for RAB4B Gene Hs.631539

genes like me logo Genes that share expression patterns with RAB4B: view

Protein tissue co-expression partners for RAB4B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RAB4B Gene

Orthologs for RAB4B Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB4B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAB4B 35
  • 92.8 (n)
  • 100 (a)
-- 36
  • 77 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RAB4B 35
  • 94.37 (n)
  • 100 (a)
RAB4B 36
  • 89 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rab4b 35
  • 91.55 (n)
  • 99.53 (a)
Rab4b 16
Rab4b 36
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rab4b 35
  • 91.86 (n)
  • 99.53 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RAB4B 36
  • 100 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 92 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rab4b 35
  • 72.61 (n)
  • 86.38 (a)
zebrafish
(Danio rerio)
Actinopterygii rab4b 35
  • 79.03 (n)
  • 91.08 (a)
rab4b 36
  • 92 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Rab-RP4 37
  • 45 (a)
Rab4 37
  • 75 (a)
Rab4 35
  • 67.93 (n)
  • 78.2 (a)
Rab4 36
  • 77 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004204 35
  • 71.12 (n)
  • 79.21 (a)
worm
(Caenorhabditis elegans)
Secernentea F11A5.4 37
  • 52 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13157 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
OneToMany
Species with no ortholog for RAB4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB4B Gene

ENSEMBL:
Gene Tree for RAB4B (if available)
TreeFam:
Gene Tree for RAB4B (if available)

Paralogs for RAB4B Gene

genes like me logo Genes that share paralogs with RAB4B: view

Variants for RAB4B Gene

Structural Variations from Database of Genomic Variants (DGV) for RAB4B Gene

Variant ID Type Subtype PubMed ID
nsv833832 CNV Loss 17160897
esv26234 CNV Loss 19812545
dgv1084e1 CNV Complex 17122850

Variation tolerance for RAB4B Gene

Residual Variation Intolerance Score: 31.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.10; 2.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB4B Gene

HapMap Linkage Disequilibrium report
RAB4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RAB4B Gene

Disorders for RAB4B Gene

Relevant External Links for RAB4B

Genetic Association Database (GAD)
RAB4B
Human Genome Epidemiology (HuGE) Navigator
RAB4B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB4B
genes like me logo Genes that share disorders with RAB4B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB4B Gene

Publications for RAB4B Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  2. Rab4b controls an early endosome sorting event by interacting with the I^-subunit of the clathrin adaptor complex 1. (PMID: 24006255) Perrin L. … Mireille C. (J. Cell. Sci. 2013) 67
  3. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. (PMID: 22080838) Cho M.H. … . (Hum. Mol. Genet. 2012) 67
  4. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PMID: 22223895) Bienvenut W.V. … Giglione C. (Mol. Cell Proteomics 2012) 67
  5. Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. (PMID: 22081228) Khor C.C. … . (Nat. Genet. 2011) 67

Products for RAB4B Gene

Sources for RAB4B Gene

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