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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB4B Gene

protein-coding   GIFtS: 56
GCID: GC19P041284

RAB4B, Member RAS Oncogene Family

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
RAB4B, Member RAS Oncogene Family1 2
Ras-Related GTP-Binding Protein 4b1 2
Small GTP Binding Protein RAB4B1 2
Ras-Related Protein Rab-4B2

External Ids:    HGNC: 97821   Entrez Gene: 539162   Ensembl: ENSG000001675787   OMIM: 6129455   UniProtKB: P610183   
ORGUL members:         
NONCODE14:n410559 n410557      

Export aliases for RAB4B gene to outside databases

Previous GC identifers: GC19P041923 GC19P041675 GC19P045960 GC19P045974 GC19P045977 GC19P045979 GC19P037717


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAB4B Gene:
RAB proteins, such as RAB4B, are members of the RAS superfamily of small GTPases that are involved in vesicular
trafficking (He et al., 2002 (PubMed 12450215)).(supplied by OMIM, Aug 2009)

GeneCards Summary for RAB4B Gene: 
RAB4B (RAB4B, member RAS oncogene family) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with RAB4B include hermansky-pudlak syndrome, and among its related super-pathways are Clathrin-dependent protein traffic and Regulation of CFTR activity (norm and CF). GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB19.

UniProtKB/Swiss-Prot: RAB4B_HUMAN, P61018
Function: Protein transport. Probably involved in vesicular traffic (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB4B gene promoter:
         E2F-4   E2F-3a   C/EBPbeta   AP-1   ATF-2   E2F-2   E2F   E2F-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAB4B promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB4B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

RAB4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB4B gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P041284:  view genomic region     (about GC identifiers)

Start:
41,284,121 bp from pter      End:
41,302,849 bp from pter
Size:
18,729 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for RAB4B

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RAB4B_HUMAN, P61018 (See protein sequence)
Recommended Name: Ras-related protein Rab-4B  
Size: 213 amino acids; 23587 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
1 PDB 3D structure from and Proteopedia for RAB4B:
2O52 (3D)    
Secondary accessions: P22750 Q7Z514 Q9HBR6
Alternative splicing: 2 isoforms:  P61018-1   P61018-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAB4B: NX_P61018

Explore proteomics data for RAB4B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P61018

  • RAB4B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAB4B Protein Expression
    REFSEQ proteins: NP_057238.3  
    ENSEMBL proteins: 
     ENSP00000470246   ENSP00000367557   ENSP00000471504   ENSP00000471803   ENSP00000349560  

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    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----

    RAB4B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P61018

    ProtoNet protein and cluster: P61018

    4 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB002041 GTP-binding nuclear protein Ran
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RAB4B_HUMAN, P61018
    Similarity: Belongs to the small GTPase superfamily. Rab family


    RAB4B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAB4B_HUMAN, P61018
    Function: Protein transport. Probably involved in vesicular traffic (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005525GTP binding IEA--
         
    RAB4B for ontologies           About GeneDecksing


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    SwitchGear 3'UTR luciferase reporter plasmidRAB4B 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAB4B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Clathrin-dependent protein traffic
    Clathrin-dependent protein traffic0.66
    wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)0.37
    Transport Clathrin-coated vesicle cycle0.66
    2wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
    wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)0.38
    3Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    4Endocytic Trafficking of EGFR
    Cholesterol and Sphingolipids transport / Influx to the early endosome in lung (normal and CF)0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RAB4B
        Clathrin-dependent protein traffic

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB4B
        Epithelial Tight Junctions

    4 GeneGo (Thomson Reuters) Pathways for RAB4B
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Cholesterol and Sphingolipids transport / Influx to the early endosome in lung (normal and CF)
    wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
    Transport Clathrin-coated vesicle cycle




    RAB4B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAB4B

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for RAB4B (P610183 ENSP000003495604) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAB7AP511493, ENSP000002650624I2D: score=1 STRING: ENSP00000265062
    RABAC1Q9UI143, ENSP000002220084I2D: score=1 STRING: ENSP00000222008
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--

    RAB4B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAB4B

    Search CenterWatch for drugs/clinical trials and news about RAB4B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAB4B gene: 
    NM_016154.4  

    Unigene Clusters for RAB4B:

    RAB4B, member RAS oncogene family
    Hs.631539  [show with all ESTs], Hs.730737  [show with all ESTs]
    Unigene Representative Sequences: NR_037791, BQ948233
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000594800 ENST00000602069 ENST00000600078 ENST00000378307 ENST00000602173
    ENST00000597476 ENST00000595728 ENST00000598430 ENST00000357052(uc002opc.2 uc002opd.2 uc002ope.2 uc002opf.2)

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    SwitchGear 3'UTR luciferase reporter plasmidRAB4B 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: BC040374.1 

    24/29 DOTS entries (see all 29):

    DT.92441133  DT.121503438  DT.121503399  DT.121503310  DT.97843879  DT.100734329  DT.91750613  DT.121503455 
    DT.121503377  DT.121503359  DT.100029100  DT.215113  DT.319170  DT.121503449  DT.80101241  DT.100792663 
    DT.99954030  DT.211984  DT.95208557  DT.121503405  DT.121503376  DT.121503453  DT.95164335  DT.121503367 

    24/186 AceView cDNA sequences (see all 186):

    BU150091 BX480149 AI086169 BQ927637 AI312115 BM561937 AI270301 CA435622 
    AA815081 CA432161 AI830148 BC046927 AA418199 AI934691 BC033081 BQ957483 
    X75450 BQ279167 BM856478 AA164359 BU956946 BQ279120 BU538102 BQ686015 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RAB4B    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:        -     -                             -                     
    SP2:                                            -                     
    SP3:                                      -     -                     
    SP4:                                                                  


    ECgene alternative splicing isoforms for RAB4B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB4B expression in normal human tissues (normalized intensities)      RAB4B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATTTAGAT
    RAB4B Expression
    About this image


    RAB4B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal septum   
     
     Bone (Muscoskeletal System)
             Thoracic Rib
     
     Cartilage (Sensory Organs)
             sensory organ/nose/nasal septum   

    See RAB4B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAB4B

    SOURCE GeneReport for Unigene clusters: Hs.631539 Hs.730737
        SABiosciences Custom PCR Arrays for RAB4B
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RAB4B gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab4b1 , 5 RAB4B, member RAS oncogene family1, 5 91.55(n)1
    99.53(a)1
      7 (15.84 cM)5
    193421  NM_029391.21  NP_083667.11 
     271684245 
    lizard
    (Anolis carolinensis)
    Reptilia RAB4B6
    Uncharacterized protein
    92(a)
    1 → many
    LGf(2855333-2864739)
    zebrafish
    (Danio rerio)
    Actinopterygii rab4b1 RAB4B, member RAS oncogene family 79.03(n)
    91.08(a)
      445498  NM_001004002.1  NP_001004002.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rab41 , 3 RAB small monomeric GTPase3
    Rab-protein 41
    75(a)
    (best of 2)3
    67.77(n)1
    76.78(a)1
      369921  NM_166240.21  NP_725696.11 


    ENSEMBL Gene Tree for RAB4B (if available)
    TreeFam Gene Tree for RAB4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAB4B gene
    RAB192  RAB39A2  RAB2A2  RAB252  RAB432  RAB142  RAB39B2  RAB11B2  
    RAB11A2  RAB422  RAB4A2  RAB302  RAB4B-EGLN22  RAB2B2  
    18/92 SIMAP similar genes for RAB4B using alignment to 4 protein entries:     RAB4B_HUMAN (see all proteins) (see all similar genes):
    RAB4A    DKFZp686J06205    RAB2B    RAB14    RAB2A    RAB43
    DKFZp313C1541    RAB30    RABL2B    rab1b    RAB8B    RABL2A
    RAB33B    RAB5C    RAB11A    RAB19    RAB5B    RAB13

    RAB4B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RAB4B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv26234CNV Loss19812545
    nsv833832CNV Loss17160897
    dgv1084e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612945    OMIM disorders: --

    2 diseases for RAB4B:    About MalaCards
    hermansky-pudlak syndrome    


    RAB4B for disorders           About GeneDecksing

    Genetic Association Database (GAD): RAB4B
    Human Genome Epidemiology (HuGE) Navigator: RAB4B (1 document)

    Export disorders for RAB4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB4B gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with RAB4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide association study of COPD identifies a s usceptibility locus on chromosome 19q13. (PubMed id 22080838)1, 4 Cho M.H.... . (2012)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Rab4b is a small GTPase involved in the control of th e glucose transporter GLUT4 localization in adipocyte. (PubMed id 19590752)1 Kaddai V....Cormont M. (2009)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    9. Identification and characterization of nine novel human small GTPases showing variable expressions in liver cancer tissues. (PubMed id 12450215)1 He H.... Zhao S.Y. (2002)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 53916 HGNC: 9782 AceView: MIAandRAB4B Ensembl:ENSG00000167578 euGenes: HUgn53916
    ECgene: RAB4B H-InvDB: RAB4B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB4B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB4B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAB4B gene:
    Search GeneIP for patents involving RAB4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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