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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB4B Gene

protein-coding   GIFtS: 56
GCID: GC19P041284

RAB4B, member RAS oncogene family
 Explore 3 diseases affiliated with
RAB4B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RAB4B    

Aliases
for RAB4B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
RAB4B, Member RAS Oncogene Family1 2
FLJ786491
MGC521231
Ras-Related GTP-Binding Protein 4b2
Ras-Related Protein Rab-4B2
Small GTP Binding Protein RAB4B2

External Ids:    HGNC: 97821   Entrez Gene: 539162   Ensembl: ENSG000001675787   OMIM: 6129455   UniProtKB: P610183   
ORGUL members:         
NONCODE:n410557    

Export aliases for RAB4B gene to outside databases

Previous GC identifers: GC19P041923 GC19P041675 GC19P045960 GC19P045974 GC19P045977 GC19P045979 GC19P037717


Summaries
for RAB4B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RAB4B:
RAB proteins, such as RAB4B, are members of the RAS superfamily of small GTPases that are involved in vesicular
trafficking (He et al., 2002 (PubMed 12450215)).(supplied by OMIM, Aug 2009)

UniProtKB/Swiss-Prot: RAB4B_HUMAN, P61018
Function: Protein transport. Probably involved in vesicular traffic (By similarity)




Genomic Views
for RAB4B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB4B gene promoter:
         E2F-4   E2F-3a   C/EBPbeta   AP-1   ATF-2   E2F-2   E2F   E2F-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAB4B promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB4B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

RAB4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB4B gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P041284:  view genomic region     (about GC identifiers)

Start:
 41,284,171 bp from pter      End:
 41,302,847 bp from pter
Size:
 18,677 bases      Orientation:
 plus strand

Proteins
for RAB4B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RAB4B_HUMAN, P61018 (See protein sequence)
Recommended Name: Ras-related protein Rab-4B  
Size: 213 amino acids; 23587 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
1 PDB 3D structure from and Proteopedia for RAB4B:
2O52 (3D)    
Secondary accessions: P22750 Q7Z514 Q9HBR6
Alternative splicing: 2 isoforms:  P61018-1   P61018-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAB4B: NX_P61018

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P61018

    • RAB4B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_057238.3  
    ENSEMBL proteins: 
     ENSP00000349560   ENSP00000367557  

    Human Recombinant Protein Products: 
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    Novus Biologicals RAB4B Protein
    Novus Biologicals RAB4B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RAB4B

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular NAS--
    GO:0005739mitochondrion ----
    GO:0005886plasma membrane IEA--


    RAB4B for ontologies           About GeneDecksing



    RAB4B Antibody Products: 
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    Uscn ELISAs and CLIAs for RAB4B

    Protein Domains /
    Families
    for RAB4B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RAB4B for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type

    Graphical View of Domain Structure for InterPro Entry P61018

    ProtoNet protein and cluster: P61018

    4 Blocks protein families:
    IPB001806 Transforming protein P21 RAS signature
    IPB002041 GTP-binding nuclear protein Ran
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RAB4B_HUMAN, P61018
    Similarity: Belongs to the small GTPase superfamily. Rab family


    Function
    for RAB4B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RAB4B_HUMAN, P61018
    Function: Protein transport. Probably involved in vesicular traffic (By similarity)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAB4B
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB4B (see all 31):
    hsa-miR-3934 hsa-miR-30c hsa-miR-4254 hsa-miR-125a-3p hsa-miR-15a hsa-miR-30d hsa-miR-431 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: RAB4B 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB4B (see all 7)
    OriGene shRNA RFP: RAB4B
    OriGene siRNA: RAB4B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB4B

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RAB4B

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB4B (see all 4)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB4B 

    Cell Line
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    Search LifeMap BioReagents cell lines for RAB4B

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB4B

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS--
    GO:0005525GTP binding IEA--


    RAB4B for ontologies           About GeneDecksing



    Pathways & Interactions
    for RAB4B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Clathrin-dependent protein traffic
    		Clathrin-dependent protein traffic1.00
    		wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)0.37
    		Transport_Clathrin-coated vesicle cycle0.66
    2Neural Crest Differentiation
    		Neural Crest Differentiation1.00
    3wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
    		wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)1.00
    4Sertoli-Sertoli Cell Junction Dynamics
    		Epithelial Tight Junctions0.36
    5Transport of MHC II:Ii complex along Golgi to TGN
    		Cholesterol and Sphingolipids transport / Influx to the early endosome in lung (normal and CF)0.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for RAB4B
        Clathrin-dependent protein traffic

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB4B
        Epithelial Tight Junctions

    4 GeneGo (Thomson Reuters) Pathways for RAB4B
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Cholesterol and Sphingolipids transport / Influx to the early endosome in lung (normal and CF)
    wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
    Transport Clathrin-coated vesicle cycle

    1 BioSystems Pathway for RAB4B 
        Neural Crest Differentiation



    RAB4B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAB4B

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for RAB4B (P610183 ENSP000003495604) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAB7AP511493, ENSP000002650624I2D: score=1 STRING: ENSP00000265062
    RABAC1Q9UI143, ENSP000002220084I2D: score=1 STRING: ENSP00000222008
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process NAS--
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport IEA--
    GO:0016192vesicle-mediated transport NAS--


    RAB4B for ontologies           About GeneDecksing



    Drugs & Compounds
    for RAB4B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAB4B
    Search CenterWatch for drugs/clinical trials and news about RAB4B 

    Transcripts
    for RAB4B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RAB4B gene: 
    NM_016154.4  

    Unigene Clusters for RAB4B:

    RAB4B, member RAS oncogene family
    Hs.631539  [show with all ESTs], Hs.730737  [show with all ESTs]
    Unigene Representative Sequences: NR_037791, BQ897013
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357052(uc002opc.2 uc002opd.2 uc002ope.2 uc002opf.2)
    ENST00000378307

    miRNA
    Products:             		 OriGene 3'-UTR Clone: RAB4B
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAB4B
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB4B (see all 31):
    hsa-miR-3934 hsa-miR-30c hsa-miR-4254 hsa-miR-125a-3p hsa-miR-15a hsa-miR-30d hsa-miR-431 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: RAB4B 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB4B (see all 7)
    OriGene shRNA RFP: RAB4B
    OriGene siRNA: RAB4B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB4B
    Clone
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    GenScript: all cDNA clones in your preferred vector: RAB4B (NM_016154)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB4B 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAB4B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB4B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB4B

    Additional cDNA sequence: BC040374.1 

    24/28 DOTS entries (see all 28):

    DT.92441133  DT.121503438  DT.121503399  DT.121503310  DT.97843879  DT.100734329  DT.91750613  DT.121503377 
    DT.121503455  DT.121503359  DT.100029100  DT.215113  DT.121503449  DT.100792663  DT.99954030  DT.211984 
    DT.95208557  DT.121503405  DT.80101241  DT.121503376  DT.121503453  DT.95164335  DT.121503367  DT.121503386 

    24/186 AceView cDNA sequences (see all 186):

    BU538102 CA432161 AA418199 BQ927637 AA815081 AI561007 BU150091 BQ279167 
    BQ686015 AF498935 BC033081 CA307435 BE674995 AW136325 BM561937 AI934691 
    BQ957483 AI797993 BQ935941 X75450 AK024845 CD673201 AI830148 AI086169 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RAB4B    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:        -     -                             -                     
    SP2:                                            -                     
    SP3:                                      -     -                     
    SP4:                                                                  


    ECgene alternative splicing isoforms for RAB4B

    Expression
    for RAB4B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATATTTAGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RAB4B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneThoracic RibBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RAB4B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAB4B

    SOURCE GeneReport for Unigene clusters: Hs.631539 Hs.730737
        SABiosciences Custom PCR Arrays for RAB4B
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB4B

    Orthologs
    for RAB4B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RAB4B gene from 3/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia MIA6
    		 --
    		 90(a)
    		 1 → many
    		 LGf(2855521-2864702)
    zebrafish
    (Danio rerio)    		 Actinopterygii rab4b1 RAB4B, member RAS oncogene family 79.03(n)
    91.08(a)    		   445498  NM_001004002.1  NP_001004002.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Rab41 , 3 RAB small monomeric GTPase3
    Rab-protein 41    		 75(a)
    (best of 2)3
    67.77(n)1
    76.78(a)1    		   369921  NM_166240.21  NP_725696.11 


    ENSEMBL Gene Tree for RAB4B (if available)
    TreeFam Gene Tree for RAB4B (if available) 

    Paralogs
    for RAB4B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAB4B gene
    RAB39A2  RAB252  RAB2A2  RAB142  RAB39B2  RAB11B2  RAB422  RAB4A2  
    RAB11A2  RAB2B2  
    18/91 SIMAP similar genes for RAB4B using alignment to 4 protein entries:     RAB4B_HUMAN (see all proteins) (see all similar genes):
    RAB4A    rab1b    RAB14    DKFZp686J06205    RAB2A    DKFZp313C1541
    RAB11A    RAB43    RAB30    RAB11B    RAB19    DKFZp686J07132
    RAB2B    RAB13    RAB8B    RAB39B    RAB15    RAB5C

    RAB4B for paralogs           About GeneDecksing



    Genomic Variants
    for RAB4B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/386 NCBI SNPs in RAB4B are shown (see all 386)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs794526311,2
    		C,F,--41283917(+) CCCCCC/AGTACT 3 -- us2k1 int11Minor allele frequency- A:0.03WA 118
    rs1832044601,2
    		--41283930(+) AGACTA/GAATCC 3 -- us2k1 int10--------
    rs22576131,2
    		C,F,A,H,--41284004(-) GGCGGG/AGCCGA 3 -- us2k1 int15Minor allele frequency- A:0.14NA WA EA 364
    rs1161966781,2
    		F,--41284188(+) AAGGAG/TCCGGG 3 -- ut51 int1 nc-transcript-variant1Minor allele frequency- T:0.05WA 118
    rs1860676421,2
    		--41284276(+) CGACCA/GAGTCA 3 -- ut51 nc-transcript-variantint10--------
    rs1386414701,2
    		C--41284295(+) ACCTAC/TGGTGA 4 Y syn1 int11Minor allele frequency- T:0.00NA 3170
    rs1417154581,2
    		--41284397(+) TCTGGC/TGTGAT 3 -- int10--------
    rs22796991,2
    		C,F,A,H,--41284398(-) CATCAC/TACCAG 3 -- int111Minor allele frequency- T:0.17EA MN NS NA WA 2432
    rs1462478681,2
    		--41284546(+) GTTCAA/GGGAGG 3 -- int10--------
    rs1379151511,2
    		--41284642(+) GCTTAC/TGGGCT 3 -- int10--------

    HapMap Linkage Disequilibrium report for RAB4B (41284171 - 41302847 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for RAB4B
         3 CNVs: 4081 73368 5100

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    Disorders / Diseases
    for RAB4B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RAB4B for disorders           About GeneDecksing

    OMIM gene information: 612945    OMIM disorders: --

    3 diseases for RAB4B:    About MalaCards
    hermansky-pudlak syndrome    liver cancer    cholesterol

    Human Genome Epidemiology (HuGE) Navigator: RAB4B (1 document)

    Export disorders for RAB4B gene to outside databases

    Publications
    for RAB4B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB4B gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with RAB4B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
    3. A genome-wide association study of COPD identifies a s usceptibility locus on chromosome 19q13. (PubMed id 22080838)1 Cho M.H.... . (2012)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    6. Rab4b is a small GTPase involved in the control of th e glucose transporter GLUT4 localization in adipocyte. (PubMed id 19590752)1 Kaddai V....Cormont M. (2009)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    8. Identification and characterization of nine novel human small GTPases showing variable expressions in liver cancer tissues. (PubMed id 12450215)1 He H.... Zhao S.Y. (2002)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    External Searches for RAB4B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing RAB4B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 53916 HGNC: 9782 AceView: MIAandRAB4B Ensembl:ENSG00000167578 euGenes: HUgn53916
    ECgene: RAB4B H-InvDB: RAB4B

    Other Databases showing RAB4B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RAB4B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB4B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB4B Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RAB4B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RAB4B gene:
    Search GeneIP for patents involving RAB4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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