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Aliases & Descriptions for RAB4B
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ78649 1, 2 | | MGC52123 1, 2 |
| | | Descriptions |
|---|
| RAB4B, member RAS oncogene family 2 | | ras-related GTP-binding protein 4b 2 | | small GTP binding protein RAB4B 2 |
|
| | Search outside databases for aliases for RAB4B genePrevious GC identifers: GC19P041923 GC19P041675 GC19P045960 GC19P045974 GC19P045977 |
Summaries for RAB4B(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: RAB4B_HUMAN, P61018Function: Protein transport. Probably involved in vesicular traffic (By similarity) |
Genomic Location for RAB4B
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RAB4B gene 
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2RAB4B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P045979:
(about GC identifiers)
Start:
|
45,976,011 bp from pter |
End:
|
45,994,687 bp from pter |
Size:
|
18,677 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011109.15
| Proteins for RAB4B
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RAB4B_HUMAN, P61018 (See
protein sequence)Recommended Name: Ras-related protein Rab-4B Size: 213 amino acids; 23587 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
PDB structures from and Proteopedia :2O52 (3D)
 
Secondary accessions: P22750 Q7Z514 Q9HBR6Alternative splicing: 2 isoforms: P61018-1 P61018-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_057238.3
ENSEMBL proteins: ENSP00000367557 ENSP00000349560
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
NAS | -- | | GO:0005886 | plasma membrane |
IEA | -- | About this table
Antibodies for RAB4B: Assays for RAB4B: | Protein
Domains/ Families for RAB4B(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P61018
ProtoNet protein and cluster: P61018 4 Blocks protein families: IPB001806 Transforming protein P21 RAS signature IPB002041 GTP-binding nuclear protein Ran IPB003577 Ras small GTPase IPB003578 Ras small GTPase
UniProtKB/Swiss-Prot: RAB4B_HUMAN, P61018Similarity: Belongs to the small GTPase superfamily. Rab family | Gene Function for RAB4B
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016154
Applied Biosystems Silencer® siRNAs for RAB4B
Sigma-Aldrich siRNA for RAB4B  Sigma-Aldrich shRNA for RAB4B  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_016154                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016154                                  untagged cDNA clone in CMV expression vector: NM_016154 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_016154
UniProtKB/Swiss-Prot: RAB4B_HUMAN, P61018Function: Protein transport. Probably involved in vesicular traffic (By similarity)3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for RAB4B
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Sigma-Aldrich "Your Favorite Gene" Pathway for RAB4B (Your Favorite Gene powered by Ingenuity) 
--3 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- | | GO:0016192 | vesicle-mediated transport |
NAS | -- | About this table
|
Drugs & Compounds for RAB4B(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for RAB4B |
Browse Tocris compounds for RAB4B
|
Transcripts for RAB4B(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016154
Sigma-Aldrich siRNA for RAB4B  Sigma-Aldrich shRNA for RAB4B  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_016154 REFSEQ mRNAs for RAB4B gene: NM_016154.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_016154               OriGene GFP tagged cDNA clone in CMV expression vector: NM_016154                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016154                                  untagged cDNA clone in CMV expression vector: NM_016154  Additional cDNA sequence: AF165522.1 AF217985.1 AF498935.1 AK024845.1 BC033081.1 BC040374.1 BC046927.1 14 DOTS entries: DT.121503310 DT.97843879 DT.91750613 DT.121503377 DT.211984 DT.121503359 DT.215113 DT.100029100 DT.100792663 DT.99954030 DT.95208557 DT.121503405 DT.95164335 DT.121503386 24/186 AceView cDNA sequences (see all 186
):BQ686015 AF498935 BU538102 AI086169 CA432161 BC046927 AW136325 BM561937 AI493506 AI270301 AA815081 BU956946 AA418199 AI797993 AI830148 BU150091 BX280685 BQ957483 AW793349 BM856478 AI934691 AI312115 BE674995 BX480149
highest scoring ESTs for RAB4B:AW005647 AA243688 AA418027 AA418199 AA461189 AA469897 AA478683 AA496001 AA525114 AA813726 Unigene Cluster for RAB4B: RAB4B, member RAS oncogene family Hs.631539 [show with all ESTs]Unigene Representative Sequence: AF217985
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for RAB4B
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | |
| SP1: | |   | - |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for RAB4B
2 Ensembl transcripts including schematic representations: ENST00000378307
ENST00000357052
|
Expression for RAB4B
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RAB4B expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RAB4B
1 / 2 / 3 8 probe-sets matching RAB4B gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TCTCCTTCAT
SOURCE GeneReport for Unigene cluster: Hs.631539
Expression variation in blood from EXPOLDB for RAB4B |
Orthologs for RAB4B
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB4B gene from 5/11 species (see all 11
)
About this table Species with no ortholog for RAB4B
ENSEMBL Gene Tree for RAB4B | Paralogs for RAB4B(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RAB4B gene
- RAB2A2 RAB142 RAB4A2 RAB2B2
|
SNPs/Variants for RAB4B(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RAB4B (up to first 250kb)
|
Disorders & Mutations for RAB4B
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for RAB4B(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RAB4B (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 5 PubMed articles for RAB4B gene: |
Search for RAB4B
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RAB4B
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RAB4B
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB4B(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RAB4B(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RAB4B:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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