Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RAB4A Gene

protein-coding   GIFtS: 65
GCID: GC01P229406

RAB4A, Member RAS Oncogene Family


(Previous symbol: RAB4)
Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
RAB4A, Member RAS Oncogene Family1 2     HRES12
RAB41 2 3 5     HTLV-1 Related Endogenous Sequence2
HRES-12     Ras-Related Protein Rab-4A2
HRES-1/RAB42     

External Ids:    HGNC: 97811   Entrez Gene: 58672   Ensembl: ENSG000001681187   OMIM: 1795115   UniProtKB: P203383   
ORGUL members:         

Export aliases for RAB4A gene to outside databases

Previous GC identifers: GC01P227854 GC01P225101 GC01P225807 GC01P226368 GC01P225713 GC01P227473 GC01P199897


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RAB4A Gene:
This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane
trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and
recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma
membrane. Alternatively spliced transcript variants have been observed for this gene. (provided by RefSeq, Dec
2012)

GeneCards Summary for RAB4A Gene:
RAB4A (RAB4A, member RAS oncogene family) is a protein-coding gene. Diseases associated with RAB4A include chronic myelomonocytic leukemia, and becker muscular dystrophy. GO annotations related to this gene include protein transporter activity and GTP binding. An important paralog of this gene is RAB19.

UniProtKB/Swiss-Prot: RAB4A_HUMAN, P20338
Function: Protein transport. Probably involved in vesicular traffic (By similarity)

Gene Wiki entry for RAB4A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAB4A gene promoter:
         RORalpha1   LHX3b/Lhx3b   AP-2alpha isoform 3   LHX3a/Lhx3a   AP-2alpha isoform 2   AP-2alpha isoform 4   HNF-3beta   AP-2alpha   RORalpha2   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RAB4A promoter sequence
   Search Chromatin IP Primers for RAB4A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAB4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42-q43   Ensembl cytogenetic band:  1q42.13   HGNC cytogenetic band: 1q42-q43

RAB4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB4A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P229406:  view genomic region     (about GC identifiers)

Start:
229,406,822 bp from pter      End:
229,441,641 bp from pter
Size:
34,820 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RAB4A_HUMAN, P20338 (See protein sequence)
Recommended Name: Ras-related protein Rab-4A  
Size: 218 amino acids; 24390 Da
Subunit: Interacts with SGSM1, SGSM2 and SGSM3 (By similarity). Interacts with RAB11FIP1, RABEP1, ZFYVE20 and
RUFY1. Interacts (membrane-bound form) with NDRG1; the interaction involves NDRG1 in vesicular recycling of
E-cadherin
Caution: It is uncertain whether Met-1 or Met-6 is the initiator
Sequence caution: Sequence=AAA60244.1; Type=Frameshift; Positions=6;
4 PDB 3D structures from and Proteopedia for RAB4A:
1YU9 (3D)        1Z0K (3D)        2BMD (3D)        2BME (3D)    
Secondary accessions: Q5T7P7 Q9BQ44

Explore the universe of human proteins at neXtProt for RAB4A: NX_P20338

Explore proteomics data for RAB4A at MOPED

Post-translational modifications: 

  • Phosphorylated by CDK1 kinase during mitosis1
  • Ubiquitination2 at Lys63
  • Modification sites at PhosphoSitePlus

  • See RAB4A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258927.1  NP_004569.2  

    ENSEMBL proteins: 
     ENSP00000355651  
    Reactome Protein details: P20338

    RAB4A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RAB4A
    OriGene Protein Over-expression Lysate for RAB4A
    OriGene MassSpec for RAB4A
    OriGene Custom Protein Services for RAB4A
    GenScript Custom Purified and Recombinant Proteins Services for RAB4A
    Novus Biologicals RAB4A Proteins
    Novus Biologicals RAB4A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for RAB4A
    Cloud-Clone Corp. Proteins for RAB4A

    RAB4A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RAB4A
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for RAB4A  (Rab4)
    OriGene Antibodies for RAB4A
    OriGene Custom Antibody Services for RAB4A
    Novus Biologicals RAB4A Antibodies
    Abcam antibodies for RAB4A
    Cloud-Clone Corp. Antibodies for RAB4A
    ThermoFisher Antibody for RAB4A
    LSBio Antibodies in human, mouse, rat for RAB4A

    RAB4A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RAB4A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RAB4A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RAB4A
    Cloud-Clone Corp. CLIAs for RAB4A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P20338

    ProtoNet protein and cluster: P20338

    1 Blocks protein domain: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RAB4A_HUMAN, P20338
    Similarity: Belongs to the small GTPase superfamily. Rab family


    RAB4A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAB4A_HUMAN, P20338
    Function: Protein transport. Probably involved in vesicular traffic (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA15907487
    GO:0005515protein binding IPI16034420
    GO:0005525GTP binding IDA15907487
    GO:0008565protein transporter activity IEA--
    GO:0019003GDP binding IDA15907487
         
    RAB4A for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RAB4A:
     Decreased cilium length after   Decreased melanin production  Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAB4A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RAB4A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAB4A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAB4A

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat RAB4A using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate RAB4A:
    hsa-miR-138-1* hsa-miR-217 hsa-miR-3662 hsa-miR-3156-5p
    SwitchGear 3'UTR luciferase reporter plasmidRAB4A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RAB4A
    Predesigned siRNA for gene silencing in human, mouse, rat RAB4A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RAB4A

    Clone
    Products:
         
    OriGene clones in human, mouse for RAB4A (see all 6)
    OriGene ORF clones in mouse, rat for RAB4A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RAB4A (NM_004578)
    Sino Biological Human cDNA Clone for RAB4A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAB4A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB4A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RAB4A
    Browse ESI BIO Cell Lines and PureStem Progenitors for RAB4A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB4A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RAB4A_HUMAN, P20338: Membrane; Peripheral membrane protein. Cytoplasm. Note=Generally associated with membranes.
    Cytoplasmic when phosphorylated by CDK1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    endosome2
    plasma membrane2
    extracellular1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005768endosome IEA--
    GO:0016020membrane IEA--

    RAB4A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RAB4A About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Clathrin dependent protein traffic
    Clathrin dependent protein traffic0.66
    wtCFTR and delta508 CFTR traffic Generic schema norm and CF 0.37
    Transport Clathrin coated vesicle cycle0.66
    2Clathrin derived vesicle budding
    Membrane Trafficking0.32
    Translocation of GLUT4 to the Plasma Membrane0.32
    3Regulation of CFTR activity norm and CF
    wtCFTR and deltaF508 traffic Membrane expression norm and CF 0.38
    4Beta-Adrenergic Signaling
    Insulin Receptor Pathway0.37
    5Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RAB4A
        Epithelial Tight Junctions
    Insulin Receptor Pathway

    1 Cell Signaling Technology (CST) Pathway for RAB4A
        Cytoskeletal Signaling

    4 GeneGo (Thomson Reuters) Pathways for RAB4A
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Cholesterol and Sphingolipids transport / Influx to the early endosome in lung (normal and CF)
    wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
    Transport Clathrin-coated vesicle cycle

    2 BioSystems Pathways for RAB4A
        Insulin Signaling
    Signaling events mediated by TCPTP


    1 Reactome Pathway for RAB4A
        Translocation of GLUT4 to the plasma membrane


    1 Kegg Pathway  (Kegg details for RAB4A):
        Endocytosis


    RAB4A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including RAB4A: 
              Diabetes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RAB4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAB4A (P203381, 2, 3 ENSP000003556514) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GDI2P503951, 3, ENSP000003695384EBI-722284,EBI-1049143 I2D: score=3 STRING: ENSP00000369538
    TP53P046372, 3MINT-63547 I2D: score=5 
    SRA1Q9HD152, 3MINT-63548 I2D: score=1 
    RAB7AP511492, 3, ENSP000002650624MINT-3369790 I2D: score=1 STRING: ENSP00000265062
    PASKQ96RG22, 3, ENSP000002340404MINT-8148788 I2D: score=1 STRING: ENSP00000234040
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS2501306
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--

    RAB4A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAB4A

    4 Novoseek inferred chemical compound relationships for RAB4A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 64.1 8 16389071 (3), 9303294 (1), 16413502 (1), 15292453 (1) (see all 5)
    gtp 53.2 6 16389071 (2), 16413502 (2), 9298810 (1), 8858211 (1)
    sodium 0 1 16389071 (1)
    glucose 0 9 9182703 (6), 10320056 (1), 8943343 (1)



    RAB4A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RAB4A gene (2 alternative transcripts): 
    NM_001271998.1  NM_004578.3  

    Unigene Cluster for RAB4A:

    RAB4A, member RAS oncogene family
    Hs.296169  [show with all ESTs]
    Unigene Representative Sequence: NM_004578
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481981 ENST00000366690(uc001hth.3) ENST00000473894 ENST00000489342


    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RAB4A using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate RAB4A:
    hsa-miR-138-1* hsa-miR-217 hsa-miR-3662 hsa-miR-3156-5p
    SwitchGear 3'UTR luciferase reporter plasmidRAB4A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RAB4A
    Predesigned siRNA for gene silencing in human, mouse, rat RAB4A
    Clone
    Products:
         
    OriGene clones in human, mouse for RAB4A (see all 6)
    OriGene ORF clones in mouse, rat for RAB4A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RAB4A (NM_004578)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAB4A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB4A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RAB4A
    OriGene qSTAR qPCR primer pairs in human, mouse for RAB4A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAB4A
      QuantiTect SYBR Green Assays in human, mouse, rat RAB4A
      QuantiFast Probe-based Assays in human, mouse, rat RAB4A

    Additional mRNA sequence: 

    AF498934.1 AK223009.1 AK313807.1 AY585832.1 BC002438.1 BC004309.1 BC070287.1 BC107681.1 
    M28211.1 NR_073545.1 

    10 DOTS entries:

    DT.452406  DT.95124080  DT.100709424  DT.91763923  DT.100784308  DT.91848512  DT.121429877  DT.75118334 
    DT.121429879  DT.95124081 

    Selected AceView cDNA sequences (see all 226):

    AA810487 BC002438 NM_006542 AF498934 AI284948 BQ055622 CB529964 BU184434 
    BU541970 AI203545 BX358091 CB105949 AI015648 BE208249 CR617877 BP338704 
    AW510865 BC004309 BQ416747 AI803193 AW054692 BI256229 F05353 AU130796 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RAB4A    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
    SP1:              -                                                               
    SP2:                                                                              
    SP3:                                -                                             
    SP4:        -     -     -           -                                             
    SP5:        -     -     -                                                         


    ECgene alternative splicing isoforms for RAB4A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RAB4A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTTTACGT
    RAB4A Expression
    About this image

    RAB4A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAB4A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.296169
        Pathway & Disease-focused RT2 Profiler PCR Array including RAB4A: 
              Diabetes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RAB4A
    OriGene qSTAR qPCR primer pairs in human, mouse for RAB4A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAB4A
    QuantiTect SYBR Green Assays in human, mouse, rat RAB4A
    QuantiFast Probe-based Assays in human, mouse, rat RAB4A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB4A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for RAB4A gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab4a1 , 5 RAB4A, member RAS oncogene family1, 5 86.54(n)1
    97.71(a)1
      8 (72.19 cM)5
    193411  NM_009003.31  NP_033029.21 
     1238059855 
    chicken
    (Gallus gallus)
    Aves RAB4A1 RAB4A, member RAS oncogene family 85.17(n)
    98.62(a)
      421532  XM_419573.4  XP_419573.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAB4A6
    RAB4A, member RAS oncogene family
    89(a)
    1 ↔ 1
    1(222126223-222132156)
    African clawed frog
    (Xenopus laevis)
    Amphibia rab4a-prov2 RAB4A, member RAS oncogene family 77.95(n)    BC044974.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc93b032 Danio rerio RAB4A, mRNA (cDNA clone IMAGE6792084) 80.46(n)    BC056535.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rab43 RAB small monomeric GTPase 77(a)     --


    ENSEMBL Gene Tree for RAB4A (if available)
    TreeFam Gene Tree for RAB4A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RAB4A gene
    RAB192  RAB39A2  RAB2A2  RAB252  RAB432  RAB142  RAB4B2  RAB39B2  
    RAB11B2  RAB11A2  RAB422  RAB302  RAB4B-EGLN22  RAB2B2  
    Selected SIMAP similar genes for RAB4A using alignment to 1 protein entry:     RAB4A_HUMAN(see all similar genes):
    RAB4B    RAB2A    RAB14    DKFZp686J07132    RAB2B    DKFZp313C1541
    RAB43    RAB30    RAB15    RAB13    RAB39B    RAB8B
    RAB11A    RAB11B    RAB17    RAB19    RAB5B    RAB37

    RAB4A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RAB4A (see all 617)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs768439291,2
    C,F--229405088(+) TTCATT/CTTCCA 3 -- us2k11Minor allele frequency- C:0.08WA 118
    rs1854195551,2
    --229405098(+) ACAAAC/GTAGAA 3 -- us2k10--------
    rs1903211071,2
    --229405129(+) TGGCAC/GCATAA 3 -- us2k10--------
    rs1144787631,2
    F--229405270(+) CTAACG/AAATAG 3 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1150133201,2
    C,F--229405396(+) ATGCAG/CAGAGA 3 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1137996981,2
    F--229405451(+) ATATAC/TAAAAC 3 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1867302771,2
    --229405524(+) AACTGC/TATTTA 3 -- us2k10--------
    rs557012111,2
    C,F--229405559(+) AGAAAA/GATACC 3 -- us2k13Minor allele frequency- G:0.11WA CSA 122
    rs1119912371,2
    C,F--229405652(+) ACACAG/AAAGTA 3 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1482878971,2
    --229405818(+) TTTCCC/GATAAA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAB4A (229406822 - 229441641 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RAB4A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673164CNV Deletion23128226
    esv25148CNV Loss19812545
    nsv827119CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing RAB4A:
    Pancreatic Cancer
    SeqTarget long-range PCR primers for resequencing RAB4A
    DNA2.0 Custom Variant and Variant Library Synthesis for RAB4A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 179511    OMIM disorders: --

    11 diseases for RAB4A:    About MalaCards
    chronic myelomonocytic leukemia    becker muscular dystrophy    muscular dystrophy    insulin resistance
    alzheimer's disease    melanoma    endotheliitis    leukemia
    pancreatitis    breast cancer    neuronitis


    RAB4A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Export disorders for RAB4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RAB4A gene, integrated from 10 sources (see all 106):
    (articles sorted by number of sources associating them with RAB4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Reversible phosphorylation-dephosphorylation determines the localization of rab4 during the cell cycle. (PubMed id 1425574)1, 2, 9 van der Sluijs P.... Mellman I. (EMBO J. 1992)
    2. High resolution crystal structures of human Rab4a in its active and inactive conformations. (PubMed id 15907487)1, 2, 9 Huber S.K. and Scheidig A.J. (FEBS Lett. 2005)
    3. Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes. (PubMed id 11788822)1, 2, 9 de Renzis S.... Zerial M. (Nat. Cell Biol. 2002)
    4. Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein. (PubMed id 11786538)1, 2, 9 Lindsay A.J.... McCaffrey M.W. (J. Biol. Chem. 2002)
    5. The N-Myc down regulated Gene1 (NDRG1) is a Rab4a effector involved in vesicular recycling of E-cadherin. (PubMed id 17786215)1, 2 Kachhap S.K.... Carducci M.A. (PLoS ONE 2007)
    6. Regulation of CD4 expression via recycling by HRES-1/RAB4 controls susceptibility to HIV infection. (PubMed id 16935861)1, 2 Nagy G.... Perl A. (J. Biol. Chem. 2006)
    7. Structural basis of family-wide Rab GTPase recognition by rabenosyn- 5. (PubMed id 16034420)1, 2 Eathiraj S.... Lambright D.G. (Nature 2005)
    8. Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes. (PubMed id 14617813)1, 2 Fouraux M.A.... Pruijn G.J.M. (Mol. Biol. Cell 2004)
    9. Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis. (PubMed id 15280022)1, 2 Lindsay A.J. and McCaffrey M.W. (FEBS Lett. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5867 HGNC: 9781 AceView: RAB4A Ensembl:ENSG00000168118 euGenes: HUgn5867
    ECgene: RAB4A Kegg: 5867 H-InvDB: RAB4A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RAB4A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB4A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RAB4A gene:
    Search GeneIP for patents involving RAB4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of RAB4A
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RAB4A   OriGene RNAi products in human, mouse, rat for RAB4A  
     OriGene qPCR primer pairs and template standards for RAB4A   OriGene Protein Over-expression Lysate for RAB4A  
     OriGene MassSpec something-or-other for RAB4A   OriGene clones in human, mouse for RAB4A  
     OriGene qSTAR qPCR primer pairs in human, mouse for RAB4A   OriGene Purified Protein for RAB4A  
     OriGene ORF clones in mouse, rat for RAB4A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RAB4A   OriGene Custom Protein Services for RAB4A  

     
     
     Block miRNA regulation of human, mouse, rat RAB4A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RAB4A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAB4A Predesigned siRNA for gene silencing in human, mouse, rat RAB4A
     QuantiFast Probe-based Assays in human, mouse, rat RAB4A QuantiTect SYBR Green Assays in human, mouse, rat RAB4A
     PCR Arrays including human, mouse, rat RAB4A Search Chromatin IP Primers for RAB4A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAB4A  GeneGlobe Interaction Network for RAB4A
     Regulatory tfbs in RAB4A promoter
     GenScript Custom Purified and Recombinant Proteins Services for RAB4A GenScript cDNA clones with any tag delivered in your preferred vector for RAB4A
     GenScript Custom Assay Services for RAB4A GenScript Custom overexpressing Cell Line Services for RAB4A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for RAB4A  (Rab4)

     Search Tocris compounds for RAB4A
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for RAB4A
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RAB4A antibodies
     RAB4A proteins
     RAB4A lysates
     Antibodies for RAB4A
     See all of Abcam's Antibodies, Kits and Proteins for RAB4A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for RAB4A
     Proteins for RAB4A
     Antibodies for RAB4A
     ELISAs for RAB4A
     CLIAs for RAB4A



     Browse ESI BIO Cell Lines and PureStem Progenitors for RAB4A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB4A
     SwitchGear 3'UTR luciferase reporter plasmids for RAB4A
     SwitchGear Promoter luciferase reporter plasmids for RAB4A
     ThermoFisher Antibody for RAB4A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB4A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAB4A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RAB4A
     LSBio Antibodies in human, mouse, rat for RAB4A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RAB4A gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4