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Aliases & Descriptions for RAB4A
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| HRES-1/RAB4 1, 2 | | OTTHUMP00000035740 2 | | OTTHUMP00000042824 2 | | RAB4 2, 3, 5 |
| | | Descriptions |
|---|
| Oncogene RAB4 2 | | RAB4, member RAS oncogene family 2 | | RAB4A, member RAS oncogene family 2 |
|
| | Search outside databases for aliases for RAB4A genePrevious GC identifers: GC01P227854 GC01P225101 GC01P225807 GC01P226368 GC01P225713 |
Summaries for RAB4A(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: RAB4A_HUMAN, P20338Function: Protein transport. Probably involved in vesicular traffic (By similarity)Gene Wiki entry for RAB4A |
Genomic Location for RAB4A
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RAB4A gene 
Entrez Gene cytogenetic band: 1q42-q43 Ensembl cytogenetic band: 1q42.13 HGNC cytogenetic band: 1q42-q43RAB4A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P227473:
(about GC identifiers)
Start:
|
227,473,502 bp from pter |
End:
|
227,508,261 bp from pter |
Size:
|
34,760 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004559.13
| Proteins for RAB4A
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RAB4A_HUMAN, P20338 (See
protein sequence)Recommended Name: Ras-related protein Rab-4A Size: 213 amino acids; 23871 Da
Subunit: Interacts with RAB11FIP1, RABEP1, ZFYVE20 and RUFY1. Interacts with SGSM1, SGSM2 and SGSM3 (By similarity)
Subcellular location: Membrane; Peripheral membrane protein. Cytoplasm. Note=Generally associated with membranes. Cytoplasmic when phosphorylated by CDC2
PDB structures from and Proteopedia :1YU9 (3D)
 1Z0K (3D)
 2BMD (3D)
 2BME (3D)
 
Secondary accessions: Q5T7P7 Q9BQ44Post-translational modifications:
Phosphorylated by CDC2 kinase during mitosis1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_004569.2
ENSEMBL proteins: ENSP00000355651
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: RAB4A 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for RAB4A: Assays for RAB4A: | Protein
Domains/ Families for RAB4A(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P20338
ProtoNet protein and cluster: P20338 1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: RAB4A_HUMAN, P20338Similarity: Belongs to the small GTPase superfamily. Rab family | Gene Function for RAB4A
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004578
Applied Biosystems Silencer® siRNAs for RAB4A
Sigma-Aldrich siRNA for RAB4A  Sigma-Aldrich shRNA for RAB4A  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004578                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004578                                  untagged cDNA clone in CMV expression vector: NM_004578 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004578
UniProtKB/Swiss-Prot: RAB4A_HUMAN, P20338Function: Protein transport. Probably involved in vesicular traffic (By similarity)3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for RAB4A
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Sigma-Aldrich "Your Favorite Gene" Pathway for RAB4A (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for RAB4A 
5/7 Interacting proteins for RAB4A (P203382) via UniProtKB, MINT, and/or STRING (see all 7
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- | About this table
|
Drugs & Compounds for RAB4A(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for RAB4A |
Browse Tocris compounds for RAB4A 4 Novoseek chemical compound relationships for RAB4A gene
About this table
|
Transcripts for RAB4A(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004578
Sigma-Aldrich siRNA for RAB4A  Sigma-Aldrich shRNA for RAB4A  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004578 REFSEQ mRNAs for RAB4A gene: NM_004578.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004578               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004578                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004578                                  untagged cDNA clone in CMV expression vector: NM_004578  Additional cDNA sequence: AF498934.1 AK223009.1 AK313807.1 AY585832.1 BC002438.1 BC004309.1 CR602754.1 CR604213.1 CR604401.1 CR605031.1 CR615332.1 CR617877.1 M28211.1 9 DOTS entries: DT.452406 DT.95124080 DT.100709424 DT.91763923 DT.100784308 DT.91848512 DT.121429877 DT.75118334 DT.95124081 24/226 AceView cDNA sequences (see all 226
):AI803193 CB105949 CR602754 CB529964 CB250394 NM_004578 BQ055622 Z44753 AI871299 AI394208 CR615332 CR605031 AI031985 AU130796 AI203545 AI479971 AA099743 NM_006542 BX358091 CR617877 CR604213 BE208249 BC004309 CR604401
highest scoring ESTs for RAB4A:AA001687 AA084625 AA099743 AA234586 AA280807 AA280857 AA296757 AA377755 AA381010 AA452226 Unigene Cluster for RAB4A: RAB4A, member RAS oncogene family Hs.296169 [show with all ESTs]Unigene Representative Sequence: AY585832
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for RAB4A
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | |
| SP1: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | - |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for RAB4A
1 Ensembl transcript including schematic representation: ENST00000366690
|
Expression for RAB4A
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RAB4A expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RAB4A
1 / 2 / 3 10 probe-sets matching RAB4A gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GTGTTTACGT
SOURCE GeneReport for Unigene cluster: Hs.296169
Expression variation in blood from EXPOLDB for RAB4A |
Orthologs for RAB4A
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB4A gene from 5/11 species (see all 11
)
About this table Species with no ortholog for RAB4A
ENSEMBL Gene Tree for RAB4A | Paralogs for RAB4A(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RAB4A gene
- RAB2A2 RAB142 RAB4B2 RAB2B2
|
SNPs/Variants for RAB4A(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RAB4A (up to first 250kb)
|
Disorders & Mutations for RAB4A
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 179511
|
Medical News for RAB4A(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RAB4A (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/74 PubMed articles for RAB4A gene (see all 74
):- Reversible phosphorylation-dephosphorylation determines the localization of rab4 during the cell cycle. (PubMed id 1425574)1, 3, 4 van der Sluijs P.... Mellman I. (1992)
- Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes. (PubMed id 11788822)1, 3, 4 de Renzis S.... Zerial M. (2002)
- Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein. (PubMed id 11786538)1, 3, 4 Lindsay A.J.... McCaffrey M.W. (2002)
- Regulation of CD4 expression via recycling by HRES-1/RAB4 controls susceptibility to HIV infection. (PubMed id 16935861)3, 4 Nagy G.... Perl A. (2006)
- Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes. (PubMed id 14617813)3, 4 Fouraux M.A.... Pruijn G.J.M. (2004)
- Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis. (PubMed id 15280022)3, 4 Lindsay A.J. and McCaffrey M.W. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Rabaptin4, a novel effector of the samll GTPase rab4a, is recruited to perinuclear recycling vesicles. (PubMed id 10698684)3, 4 Nagelkerken B.... van der Sluijs P. (2000)
- Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2. (PubMed id 1902553)3, 4 Bailly E.... Bornens M. (1991)
- The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. (PubMed id 2501306)3, 4 Zahraoui A.... Tavitian A. (1989)
|
Search for RAB4A
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RAB4A
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RAB4A
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB4A(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RAB4A(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RAB4A:

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| Antibodies & Assays for RAB4A  (Rab4) |
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| | | Search Tocris compounds for RAB4A |
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