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Aliases for RAB4A Gene

Aliases for RAB4A Gene

  • RAB4A, Member RAS Oncogene Family 2 3 5
  • RAB4 3 4
  • HTLV-1 Related Endogenous Sequence 3
  • HRES-1/RAB4 3
  • HRES-1 3
  • HRES1 3

External Ids for RAB4A Gene

Previous HGNC Symbols for RAB4A Gene

  • RAB4

Previous GeneCards Identifiers for RAB4A Gene

  • GC01P227854
  • GC01P225101
  • GC01P225807
  • GC01P226368
  • GC01P225713
  • GC01P227473
  • GC01P229406
  • GC01P199897

Summaries for RAB4A Gene

Entrez Gene Summary for RAB4A Gene

  • This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for RAB4A Gene

RAB4A (RAB4A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB4A include Chilblain Lupus. Among its related pathways are Regulation of CFTR activity (norm and CF) and Translocation of GLUT4 to the plasma membrane. GO annotations related to this gene include GTP binding and protein transporter activity. An important paralog of this gene is RAB39A.

UniProtKB/Swiss-Prot for RAB4A Gene

  • Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Wiki entry for RAB4A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB4A Gene

Genomics for RAB4A Gene

Regulatory Elements for RAB4A Gene

Enhancers for RAB4A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RAB4A on UCSC Golden Path with GeneCards custom track

Promoters for RAB4A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAB4A on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB4A Gene

Chromosome:
1
Start:
229,271,062 bp from pter
End:
229,305,894 bp from pter
Size:
34,833 bases
Orientation:
Plus strand

Genomic View for RAB4A Gene

Genes around RAB4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB4A Gene

Proteins for RAB4A Gene

  • Protein details for RAB4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20338-RAB4A_HUMAN
    Recommended name:
    Ras-related protein Rab-4A
    Protein Accession:
    P20338
    Secondary Accessions:
    • Q5T7P7
    • Q9BQ44

    Protein attributes for RAB4A Gene

    Size:
    218 amino acids
    Molecular mass:
    24390 Da
    Quaternary structure:
    • Interacts with SGSM1, SGSM2 and SGSM3 (By similarity). Interacts with RAB11FIP1, RABEP1, ZFYVE20 and RUFY1. Interacts (membrane-bound form) with NDRG1; the interaction involves NDRG1 in vesicular recycling of E-cadherin.
    SequenceCaution:
    • Sequence=AAA60244.1; Type=Frameshift; Positions=6; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAB4A Gene

neXtProt entry for RAB4A Gene

Proteomics data for RAB4A Gene at MOPED

Post-translational modifications for RAB4A Gene

Other Protein References for RAB4A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RAB4A (Rab4)

No data available for DME Specific Peptides for RAB4A Gene

Domains & Families for RAB4A Gene

Gene Families for RAB4A Gene

Suggested Antigen Peptide Sequences for RAB4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20338

UniProtKB/Swiss-Prot:

RAB4A_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB4A: view

Function for RAB4A Gene

Molecular function for RAB4A Gene

UniProtKB/Swiss-Prot Function:
Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Ontology (GO) - Molecular Function for RAB4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA,IDA 15907487
GO:0005525 GTP binding IEA,IDA 15907487
genes like me logo Genes that share ontologies with RAB4A: view
genes like me logo Genes that share phenotypes with RAB4A: view

Animal Model Products

miRNA for RAB4A Gene

miRTarBase miRNAs that target RAB4A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB4A Gene

Localization for RAB4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB4A Gene

Membrane; Peripheral membrane protein. Cytoplasm. Note=Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB4A Gene COMPARTMENTS Subcellular localization image for RAB4A gene
Compartment Confidence
endosome 5
extracellular 5
cytosol 4
plasma membrane 4
cytoskeleton 2
golgi apparatus 2
lysosome 2
vacuole 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RAB4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048471 perinuclear region of cytoplasm IDA 19590752
genes like me logo Genes that share ontologies with RAB4A: view

Pathways & Interactions for RAB4A Gene

genes like me logo Genes that share pathways with RAB4A: view

SIGNOR curated interactions for RAB4A Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RAB4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032482 Rab protein signal transduction IEA --
GO:0032781 positive regulation of ATPase activity IEA --
genes like me logo Genes that share ontologies with RAB4A: view

Drugs & Compounds for RAB4A Gene

(4) Additional Compounds for RAB4A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RAB4A: view

Transcripts for RAB4A Gene

Unigene Clusters for RAB4A Gene

RAB4A, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB4A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: -
SP2:
SP3: -
SP4: - - - -
SP5: - - -

Relevant External Links for RAB4A Gene

GeneLoc Exon Structure for
RAB4A
ECgene alternative splicing isoforms for
RAB4A

Expression for RAB4A Gene

mRNA expression in normal human tissues for RAB4A Gene

Protein differential expression in normal tissues from HIPED for RAB4A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.5) and Brain (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB4A Gene



SOURCE GeneReport for Unigene cluster for RAB4A Gene Hs.296169

genes like me logo Genes that share expression patterns with RAB4A: view

Protein tissue co-expression partners for RAB4A Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAB4A Gene

Orthologs for RAB4A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB4A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAB4A 35
  • 90.98 (n)
  • 99.08 (a)
RAB4A 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB4A 35
  • 93.73 (n)
  • 99.54 (a)
RAB4A 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab4a 35
  • 86.54 (n)
  • 97.71 (a)
Rab4a 16
Rab4a 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab4a 35
  • 86.54 (n)
  • 98.17 (a)
oppossum
(Monodelphis domestica)
Mammalia RAB4A 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAB4A 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB4A 35
  • 85.17 (n)
  • 98.62 (a)
RAB4A 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB4A 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7138 35
African clawed frog
(Xenopus laevis)
Amphibia rab4a-prov 35
zebrafish
(Danio rerio)
Actinopterygii rab4a 35
  • 79.5 (n)
  • 96.24 (a)
wufc93b03 35
rab4a 36
  • 96 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10002 35
fruit fly
(Drosophila melanogaster)
Insecta Rab4 37
  • 77 (a)
Rab4 36
  • 77 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F11A5.4 37
  • 53 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00889 35
  • 55.14 (n)
  • 57.45 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ypt4 35
  • 53.2 (n)
  • 49.49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
OneToMany
Species with no ortholog for RAB4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB4A Gene

ENSEMBL:
Gene Tree for RAB4A (if available)
TreeFam:
Gene Tree for RAB4A (if available)

Paralogs for RAB4A Gene

genes like me logo Genes that share paralogs with RAB4A: view

Variants for RAB4A Gene

Sequence variations from dbSNP and Humsavar for RAB4A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs149157 -- 229,289,454(-) TCACT(G/T)AATTA intron-variant
rs237747 -- 229,274,578(-) TAGAA(C/T)TGTTT intron-variant
rs237748 -- 229,274,781(-) AATTT(C/T)AAAAG intron-variant
rs237749 -- 229,275,962(-) TCATA(A/C)TTTAT intron-variant
rs237750 -- 229,277,568(-) CAGAT(A/G)ACAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB4A Gene

Variant ID Type Subtype PubMed ID
esv2673164 CNV Deletion 23128226
esv25148 CNV Loss 19812545
nsv827119 CNV Gain 20364138

Variation tolerance for RAB4A Gene

Residual Variation Intolerance Score: 60.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.53% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RAB4A Gene

Disorders for RAB4A Gene

MalaCards: The human disease database

(1) MalaCards diseases for RAB4A Gene - From: DISEASES

Disorder Aliases PubMed IDs
chilblain lupus
  • chilblain lupus 1
- elite association - COSMIC cancer census association via MalaCards
Search RAB4A in MalaCards View complete list of genes associated with diseases

Relevant External Links for RAB4A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB4A
genes like me logo Genes that share disorders with RAB4A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB4A Gene

Publications for RAB4A Gene

  1. Reversible phosphorylation-dephosphorylation determines the localization of rab4 during the cell cycle. (PMID: 1425574) van der Sluijs P. … Mellman I. (EMBO J. 1992) 3 4 23 67
  2. D-AKAP2 interacts with Rab4 and Rab11 through its RGS domains and regulates transferrin receptor recycling. (PMID: 19797056) Eggers C.T. … Taylor S.S. (J. Biol. Chem. 2009) 3 23
  3. Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter. (PMID: 18227069) Ahmed B.A. … Kilic F. (J. Biol. Chem. 2008) 3 23
  4. Phosphorylation state of mu-opioid receptor determines the alternative recycling of receptor via Rab4 or Rab11 pathway. (PMID: 18550774) Wang F. … Ma L. (Mol. Endocrinol. 2008) 3 23
  5. Rab4 GTP/GDP modulates amiloride-sensitive sodium channel (ENaC) function in colonic epithelia. (PMID: 16389071) Saxena S.K. … George C. (Biochem. Biophys. Res. Commun. 2006) 3 23

Products for RAB4A Gene

Sources for RAB4A Gene

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