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Aliases for RAB4A Gene

Aliases for RAB4A Gene

  • RAB4A, Member RAS Oncogene Family 2 3
  • RAB4 3 4
  • HTLV-1 Related Endogenous Sequence 3
  • HRES-1/RAB4 3
  • HRES-1 3
  • HRES1 3

External Ids for RAB4A Gene

Previous HGNC Symbols for RAB4A Gene

  • RAB4

Previous GeneCards Identifiers for RAB4A Gene

  • GC01P227854
  • GC01P225101
  • GC01P225807
  • GC01P226368
  • GC01P225713
  • GC01P227473
  • GC01P229406
  • GC01P199897

Summaries for RAB4A Gene

Entrez Gene Summary for RAB4A Gene

  • This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for RAB4A Gene

RAB4A (RAB4A, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Endocytosis and Cytoskeletal Signaling. GO annotations related to this gene include GTP binding and protein transporter activity. An important paralog of this gene is RAB42.

UniProtKB/Swiss-Prot for RAB4A Gene

  • Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Wiki entry for RAB4A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB4A Gene

Genomics for RAB4A Gene

Genomic Location for RAB4A Gene

Chromosome:
1
Start:
229,271,062 bp from pter
End:
229,305,894 bp from pter
Size:
34,833 bases
Orientation:
Plus strand

Genomic View for RAB4A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB4A Gene

Proteins for RAB4A Gene

  • Protein details for RAB4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20338-RAB4A_HUMAN
    Recommended name:
    Ras-related protein Rab-4A
    Protein Accession:
    P20338
    Secondary Accessions:
    • Q5T7P7
    • Q9BQ44

    Protein attributes for RAB4A Gene

    Size:
    218 amino acids
    Molecular mass:
    24390 Da
    Quaternary structure:
    • Interacts with SGSM1, SGSM2 and SGSM3 (By similarity). Interacts with RAB11FIP1, RABEP1, ZFYVE20 and RUFY1. Interacts (membrane-bound form) with NDRG1; the interaction involves NDRG1 in vesicular recycling of E-cadherin.
    SequenceCaution:
    • Sequence=AAA60244.1; Type=Frameshift; Positions=6; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAB4A Gene

neXtProt entry for RAB4A Gene

Proteomics data for RAB4A Gene at MOPED

Post-translational modifications for RAB4A Gene

Other Protein References for RAB4A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RAB4A (Rab4)

No data available for DME Specific Peptides for RAB4A Gene

Domains & Families for RAB4A Gene

Gene Families for RAB4A Gene

Suggested Antigen Peptide Sequences for RAB4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20338

UniProtKB/Swiss-Prot:

RAB4A_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB4A: view

Function for RAB4A Gene

Molecular function for RAB4A Gene

UniProtKB/Swiss-Prot Function:
Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Ontology (GO) - Molecular Function for RAB4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity IEA --
GO:0003924 GTPase activity IDA 15907487
GO:0005515 protein binding IPI 16034420
GO:0005525 GTP binding IDA 15907487
GO:0008565 protein transporter activity IEA --
genes like me logo Genes that share ontologies with RAB4A: view
genes like me logo Genes that share phenotypes with RAB4A: view

Animal Model Products

miRNA for RAB4A Gene

miRTarBase miRNAs that target RAB4A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB4A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB4A Gene

Localization for RAB4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB4A Gene

Membrane; Peripheral membrane protein. Cytoplasm. Note=Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB4A Gene COMPARTMENTS Subcellular localization image for RAB4A gene
Compartment Confidence
extracellular 5
endosome 3
cytoskeleton 2
cytosol 2
golgi apparatus 2
lysosome 2
plasma membrane 2
vacuole 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RAB4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm --
GO:0005768 endosome IBA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with RAB4A: view

Pathways & Interactions for RAB4A Gene

genes like me logo Genes that share pathways with RAB4A: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for RAB4A Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RAB4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction --
GO:0015031 protein transport --
genes like me logo Genes that share ontologies with RAB4A: view

Drugs & Compounds for RAB4A Gene

(4) Additional Compounds for RAB4A Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
gdp
glucose
gtp
Partial agonist, Agonist
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with RAB4A: view

Transcripts for RAB4A Gene

Unigene Clusters for RAB4A Gene

RAB4A, member RAS oncogene family:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB4A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB4A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: -
SP2:
SP3: -
SP4: - - - -
SP5: - - -

Relevant External Links for RAB4A Gene

GeneLoc Exon Structure for
RAB4A
ECgene alternative splicing isoforms for
RAB4A

Expression for RAB4A Gene

mRNA expression in normal human tissues for RAB4A Gene

Protein differential expression in normal tissues from HIPED for RAB4A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.5) and Brain (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB4A Gene



SOURCE GeneReport for Unigene cluster for RAB4A Gene Hs.296169

genes like me logo Genes that share expression patterns with RAB4A: view

Protein tissue co-expression partners for RAB4A Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAB4A Gene

Orthologs for RAB4A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB4A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAB4A 35
  • 90.98 (n)
  • 99.08 (a)
RAB4A 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB4A 35
  • 93.73 (n)
  • 99.54 (a)
RAB4A 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab4a 35
  • 86.54 (n)
  • 97.71 (a)
Rab4a 16
Rab4a 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab4a 35
  • 86.54 (n)
  • 98.17 (a)
oppossum
(Monodelphis domestica)
Mammalia RAB4A 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAB4A 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB4A 35
  • 85.17 (n)
  • 98.62 (a)
RAB4A 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB4A 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7138 35
African clawed frog
(Xenopus laevis)
Amphibia rab4a-prov 35
zebrafish
(Danio rerio)
Actinopterygii rab4a 35
  • 79.5 (n)
  • 96.24 (a)
wufc93b03 35
rab4a 36
  • 96 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10002 35
fruit fly
(Drosophila melanogaster)
Insecta Rab4 37
  • 77 (a)
Rab4 36
  • 77 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F11A5.4 37
  • 53 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00889 35
  • 55.14 (n)
  • 57.45 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ypt4 35
  • 53.2 (n)
  • 49.49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
OneToMany
Species with no ortholog for RAB4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB4A Gene

ENSEMBL:
Gene Tree for RAB4A (if available)
TreeFam:
Gene Tree for RAB4A (if available)

Paralogs for RAB4A Gene

genes like me logo Genes that share paralogs with RAB4A: view

Variants for RAB4A Gene

Sequence variations from dbSNP and Humsavar for RAB4A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs149157 -- 229,289,454(-) TCACT(G/T)AATTA intron-variant
rs171061 -- 229,302,329(+) TTACA(C/T)GTGCA intron-variant
rs171111 -- 229,297,059(-) TATAA(A/G)GATTC intron-variant
rs237747 -- 229,274,578(-) TAGAA(C/T)TGTTT intron-variant
rs237748 -- 229,274,781(-) AATTT(C/T)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB4A Gene

Variant ID Type Subtype PubMed ID
esv2673164 CNV Deletion 23128226
esv25148 CNV Loss 19812545
nsv827119 CNV Gain 20364138

Variation tolerance for RAB4A Gene

Residual Variation Intolerance Score: 60.32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB4A Gene

HapMap Linkage Disequilibrium report
RAB4A

PCR Panel Products

  • Copy Number PCR Panels: for RAB4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB4A Gene

Disorders for RAB4A Gene

Relevant External Links for RAB4A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB4A
genes like me logo Genes that share disorders with RAB4A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB4A Gene

Publications for RAB4A Gene

  1. Changes in protein expression after neoadjuvant use of aromatase inhibitors in primary breast cancer: a proteomic approach to search for potential biomarkers to predict response or resistance. (PMID: 20374034) Yiu C.C. … Chow L.W. (Expert Opin Investig Drugs 2010) 23 67
  2. D-AKAP2 interacts with Rab4 and Rab11 through its RGS domains and regulates transferrin receptor recycling. (PMID: 19797056) Eggers C.T. … Taylor S.S. (J. Biol. Chem. 2009) 23 67
  3. Phosphorylation state of mu-opioid receptor determines the alternative recycling of receptor via Rab4 or Rab11 pathway. (PMID: 18550774) Wang F. … Ma L. (Mol. Endocrinol. 2008) 23 67
  4. Rab4 and Rab11 coordinately regulate the recycling of angiotensin II type I receptor as demonstrated by fluorescence resonance energy transfer microscopy. (PMID: 18601530) Li H. … Jose P.A. (J Biomed Opt 2008) 23 67
  5. Glucagon receptor recycling: role of carboxyl terminus, beta-arrestins, and cytoskeleton. (PMID: 18787074) Krilov L. … Bouscarel B. (Am. J. Physiol., Cell Physiol. 2008) 23 67

Products for RAB4A Gene

Sources for RAB4A Gene

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