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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB44 Gene

protein-coding   GIFtS: 29
GCID: GC06P036778

RAB44, Member RAS Oncogene Family

(Previous names: RASD family, member 3)
(Previous symbols: RASD3, RASL13)
  Search for RAB44
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAB44, Member RAS Oncogene Family1 2     dJ431A14.32
RASD31 2     RAS-Like, Family 132
RASL131 2     Ras-Related Protein Rab-442
RASD Family, Member 31 2     

External Ids:    HGNC: 210681   Entrez Gene: 4012582   Ensembl: ENSG000002555877   UniProtKB: Q7Z6P33   

Export aliases for RAB44 gene to outside databases

Previous GC identifers: GC06U900627 GC06P036799 GC06P036665


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RAB44 Gene: 
RAB44 (RAB44, member RAS oncogene family) is a protein-coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is RASEF.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for RAB44
         Other transcription factors

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   Search SABiosciences Chromatin IP Primers for RAB44

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB44


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31-p21.2   Ensembl cytogenetic band:  6p21.2   HGNC cytogenetic band: 6p21.31-p21.2

RAB44 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB44 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P036778:  view genomic region     (about GC identifiers)

Start:
36,685,065 bp from pter      End:
36,699,870 bp from pter
Size:
14,806 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RAB44_HUMAN, Q7Z6P3 (See protein sequence)
Recommended Name: Ras-related protein Rab-44  
Size: 723 amino acids; 77638 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Sequence caution: Sequence=CAD92808.1; Type=Erroneous gene model prediction;

Explore the universe of human proteins at neXtProt for RAB44: NX_Q7Z6P3

Explore proteomics data for RAB44 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z6P3

  • RAB44 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAB44 Protein Expression
    REFSEQ proteins: NP_001244286.1  
    ENSEMBL proteins: 
     ENSP00000229824  

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    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----

    RAB44 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q7Z6P3

    ProtoNet protein and cluster: Q7Z6P3

    UniProtKB/Swiss-Prot: RAB44_HUMAN, Q7Z6P3
    Similarity: Belongs to the small GTPase superfamily. Rab family


    RAB44 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005525GTP binding IEA--
         
    RAB44 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAB44

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport IEA--

    RAB44 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RAB44

    Search CenterWatch for drugs/clinical trials and news about RAB44

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for RAB44 gene (2 alternative transcripts): 
    NM_207498.1  NM_001257357.1  

    Unigene Cluster for RAB44:

    RAB44, member RAS oncogene family
    Hs.485258  [show with all ESTs]
    Unigene Representative Sequence: NM_001257357
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000229824
    miRNA
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    Additional mRNA sequence: AK125083.1 

    2 DOTS entries:

    DT.101961390  DT.121354600 

    3 AceView cDNA sequences:

    NM_207498 AK125083 AI310599 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB44 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTGCGTTT
    RAB44 Expression
    About this image


    See RAB44 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.485258
        SABiosciences Custom PCR Arrays for RAB44
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RAB44 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab445 RAB44, member RAS oncogene family   --   17 (15.14 cM) 29135056 
    chicken
    (Gallus gallus)
    Aves RAB446
    RAB44, member RAS oncogene family
    47(a)
    1 ↔ 1
    26(1553858-1557199)
    lizard
    (Anolis carolinensis)
    Reptilia RAB446
    Uncharacterized protein
    54(a)
    1 ↔ 1
    4(123583936-123592083)
    fruit fly
    (Drosophila melanogaster)
    Insecta Rab276
    Rab27
    29(a)
    1 → many
    X(1367917-1370963)
    worm
    (Caenorhabditis elegans)
    Secernentea aex-66
    Protein AEX-6
    34(a)
    1 → many
    I(13543094-13545190)


    ENSEMBL Gene Tree for RAB44 (if available)
    TreeFam Gene Tree for RAB44 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAB44 gene
    RASEF2  RAB262  RAB152  RAB372  
    18/83 SIMAP similar genes for RAB44 using alignment to 1 protein entry:     RAB44_HUMAN(see all similar genes):
    DKFZp686J06205    rab1b    DKFZp686J07132    RAB8B    RAB41    RAB3A
    RAB7A    RAB11A    RAB15    RAB3B    RAB11B    RAB10
    RAB3D    RAB43    RAB6B    RAB19    RAB5B    RAB13

    RAB44 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/863 SNPs in RAB44 are shown (see all 863)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1451273851,2
    C--36663647(+) ATGATG/TTCTCG 1 -- us2k10--------
    rs21450471,2
    C,F,A,H--36663652(+) gtctcA/Ggtgta 1 -- us2k117Minor allele frequency- G:0.04NS EA NA WA CSA 918
    rs1389586691,2
    --36663816(+) TTTATA/TCACAT 1 -- us2k10--------
    rs1409554631,2
    C--36663881(+) TTTACA/GGAGGG 1 -- us2k10--------
    rs759360991,2
    F--36663914(+) GATACA/GTAAGT 1 -- us2k10--------
    rs1819375961,2
    --36663968(+) TTTTGC/TCATTC 1 -- us2k10--------
    rs1997874541,2
    C--36664116(+) CTTCC-/TTTTTT 1 -- us2k10--------
    rs597868871,2
    C--36664123(+) TTTTT-/T/TCTT
            
    CTTCT
    1 -- us2k10--------
    rs1405201541,2
    C--36664131(+) CTTTC-/TCTTCTTC 1 -- cds10--------
    rs1384224681,2
    C--36664149(+) TCTTCC/TTCCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAB44 (36685065 - 36699870 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RAB44: --
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing RAB44
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB44 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with RAB44)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 401258 HGNC: 21068 AceView: FLJ43093 Ensembl:ENSG00000255587 euGenes: HUgn401258
    ECgene: RAB44 H-InvDB: RAB44

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB44 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB44 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAB44 gene:
    Search GeneIP for patents involving RAB44

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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