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RAB44 Gene

protein-coding   GIFtS: 35

GC06P036799
RAB44, member RAS oncogene family
(Previous names: RASD family, member 3 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: RASD3, RASL13)
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Aliases &
Descriptions
for RAB44

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ43093 2
RASD3 2
RASL13 2
dJ431A14.3 1, 2
Descriptions
RAB44, member RAS oncogene family 2
RAS-like, family 13 2
RASD family, member 3 1, 2
External Ids
HGNC: 210681
Entrez Gene: 4012582
UniProtKB: Q7Z6P33
Ensembl: ENSG000001120907
Search outside databases for aliases for RAB44 gene

Previous GC identifer: GC06U900627

Summaries
for RAB44

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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   --

Genomic Location
for RAB44

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31-p21.2   Ensembl cytogenetic band:  6p21.31   HGNC chromosome: 6

RAB44 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P036799:     (about GC identifiers)

Start:
 36,779,991 bp from pter
End:
 36,813,461 bp from pter
Size:
 33,471 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000006.10  NT_007592.14  

Proteins
for RAB44

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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 UniProtKB/Swiss-Prot: RAB44_HUMAN, Q7Z6P3 (See protein sequence)
Recommended Name: Ras-related protein Rab-44  
Size: 721 amino acids; 77369 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Sequence caution: Sequence=CAD92808.1; Type=Erroneous gene model prediction;



ENSEMBL proteins: 
ENSP00000229824 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005886 plasma membrane IEA--
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Antibodies for RAB44: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for RAB44

Assays for RAB44: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for RAB44

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro domains/families:
 IPR001806 Ras_GTPase
 IPR005225 Small_GTP_bd
 IPR003579 GTPase_Rab
 IPR013753 Ras


   GeneDecks  RAB44 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q7Z6P3

ProtoNet protein and cluster: Q7Z6P3

UniProtKB/Swiss-Prot: RAB44_HUMAN, Q7Z6P3
Similarity: Belongs to the small GTPase superfamily. Rab family

Gene Function
for RAB44

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (RAB44)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_207498

              Applied Biosystems Silencer® siRNAs for RAB44

              Sigma-Aldrich siRNA for RAB44  
                     Sigma-Aldrich shRNA for RAB44  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene untagged cDNA clone in CMV expression vector: NM_207498 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_207498

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000166 nucleotide binding IEA--
GO:0005525 GTP binding IEA--
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Pathways & Interactions
for RAB44

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA--
GO:0015031 protein transport IEA--
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Drugs & Compounds
for RAB44

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RAB44

Transcripts
for RAB44

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (RAB44)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_207498

              Sigma-Aldrich siRNA for RAB44  
                     Sigma-Aldrich shRNA for RAB44  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

XM_001725007  

              OriGene untagged cDNA clone in CMV expression vector: NM_207498 

Additional cDNA sequence: 

AK125083.1 XM_001725007.1 

2 DOTS entries:

DT.101961390  DT.121354600 

3 AceView cDNA sequences:

NM_207498 AK125083 AI310599 

Unigene Cluster for RAB44:

RAB44, member RAS oncogene family
Hs.485258  [show with all ESTs]
Unigene Representative Sequence: XM_001725007


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000229824  

Expression
for RAB44

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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RAB44 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for RAB44

1Data from GNF BioGPS
    About these images

About these images

CGAP SAGE TAG: GTCTGCGTTT

SOURCE GeneReport for Unigene cluster: Hs.485258

Orthologs
for RAB44

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for RAB44 gene from 5/6 species (see all 6 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 LOC4817671   -- similar to RAS and EF hand domain containing 72.18(n)
60.11(a)		 481767  XM_538888.2  XP_538888.2 
chimpanzee
(Pan troglodytes)		 LOC4719931   -- hypothetical LOC471993 93.78(n)
91.99(a)		 471993  XM_527372.2  XP_527372.2 
cow
(Bos taurus)		 LOC5203341   -- similar to FLJ43093 protein 78.76(n)
70(a)		 520334  XM_598573.3  XP_598573.3 
rat
(Rattus norvegicus)		 RGD15601501   -- similar to RIKEN cDNA 9830134C10 gene 70.27(n)
60.93(a)		 309649  XM_228043.4  XP_228043.4 
mouse
(Mus musculus)		 Rab445
9830134C10Rik1		 175
 RAB44, member RAS oncogene family5
RIKEN cDNA 9830134C10 gene1		 69.48(n)1
61.14(a)1		 4428271  NM_001002786.21  NP_001002786.11 
 AI3248705  AK0365635  (see all 7)
About this table        Species with no ortholog for RAB44

ENSEMBL Gene Tree for RAB44

Paralogs
for RAB44

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for RAB44 gene
ENSG000002060042  RASEF2  RAB152  

SNPs/Variants
for RAB44

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/239 NCBI SNPs in RAB44 are shown (see all 239 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 140)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 6 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs18945591,2
A,C,F,H,O36778378(+) TTTACC/TGCTTC 1 -- ng5118Minor allele frequency- N:0.00MN EA NA EU WA 1683
rs18647501,2
A,C,F,H36812785(-) GCTGCA/GTGGTG 1 T/M mis113Minor allele frequency- G:0.27MN EU EA WA NA 1342
rs121943671,2
A,C,F,H36813178(+) CACCCT/GCTTGC 1 R/L mis18Minor allele frequency- G:0.49EU EA WA 840
rs108071731,2
A,C,F,H36812893(+) GGTGGT/CGGGCC 1 A/V mis18Minor allele frequency- C:0.13EU EA WA 796
rs119700081,2
C,F,H36813752(+) ACTGTC/TCAGCC 1 -- ng318Minor allele frequency- T:0.24EU EA WA 840
rs132161901,2
C,F,H36813662(+) CCCTTC/TCAGGC 1 -- ng318Minor allele frequency- T:0.02EU EA WA 838
rs121991941,2
C,F,H36779370(+) TGTCAC/TGTGGG 1 -- ng518Minor allele frequency- T:0.10EU EA WA 830
rs18647491,2
C,F,H36812814(-) TCGGAG/ACAGTC 1 F/L mis18Minor allele frequency- A:0.00EU EA WA 840
rs93805931,2
C,F,H36813620(+) AATTGC/TGCTGT 1 -- ng317Minor allele frequency- T:0.16EU EA WA NA 562
rs77729061,2
F,H36798252(+) ACAAGG/ACCCGC 1 D/G mis14Minor allele frequency- A:0.02EU EA WA 420
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HapMap Linkage Disequilibrium images for RAB44 (up to first 250kb)

Disorders & Mutations
for RAB44

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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   --

Medical News
for RAB44

(Possibly Related Articles in Doctor's Guide)
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   --

Publications
for RAB44

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

1 PubMed article for RAB44 gene:

Search for RAB44

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing RAB44

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 401258 HGNC: 21068 AceView: FLJ43093 Ensembl:ENSG00000112090 euGenes: HUgn401258
ECgene: RAB44 H-InvDB: RAB44

Other Databases showing RAB44

(According to HUGE)
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   --

Specialized Databases showing RAB44

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
ATLAS Chromosomes in Cancer entry for RAB44 Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies
for RAB44

(Available from WIS Yeda, Salk, Tufts)
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  --

Services
for RAB44

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for RAB44:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for RAB44-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for RAB44 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for RAB44 Browse small molecules at Sigma-Aldrich
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 Search Novus for antibodies for RAB44

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