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Aliases for RAB44 Gene

Aliases for RAB44 Gene

  • RAB44, Member RAS Oncogene Family 2 3 5
  • RASD Family, Member 3 2 3
  • Ras-Related Protein Rab-44 3
  • RAS-Like, Family 13 3
  • DJ431A14.3 3
  • RASL13 3
  • RASD3 3

External Ids for RAB44 Gene

Previous HGNC Symbols for RAB44 Gene

  • RASD3
  • RASL13

Previous GeneCards Identifiers for RAB44 Gene

  • GC06U900627
  • GC06P036799
  • GC06P036665
  • GC06P036778
  • GC06P037311
  • GC06P036978
  • GC06P037015
  • GC06P037795
  • GC06P038418

Summaries for RAB44 Gene

GeneCards Summary for RAB44 Gene

RAB44 (RAB44, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Immune System and Metabolism of proteins. GO annotations related to this gene include calcium ion binding and GTPase activity. An important paralog of this gene is RASEF.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB44 Gene

Genomics for RAB44 Gene

Regulatory Elements for RAB44 Gene

Enhancers for RAB44 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F036592 2.5 FANTOM5 ENCODE 23.9 -100.4 -100409 10.7 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC KCTD20 ENSG00000237719 LAP3P2 CDKN1A RAB44 CMTR1 STK38 RNU1-88P RN7SL502P TBC1D22B
GH06F036622 1.3 Ensembl ENCODE 24.8 -73.8 -73841 4.0 HDGF PKNOX1 MLX ARNT SIN3A ARID4B ZNF2 SLC30A9 GLIS2 ZNF143 CDKN1A RAB44 ENSG00000251864 LAP3P2 CMTR1 KCTD20 PI16 C6orf89 MIR3925 LOC105375038
GH06F037077 1.1 Ensembl ENCODE 22.1 +380.2 380164 1.7 HDAC1 BCOR YBX3 CBX3 CREB3L1 TEAD4 ZMYM3 RAD21 CHAMP1 ZNF121 RAB44 FGD2 CDKN1A COX6A1P2 MTCH1 GC06P040039
GH06F036751 1.3 Ensembl ENCODE 17.9 +57.9 57901 7.9 HDGF PKNOX1 ZFP64 ARID4B ZNF143 FOS KLF13 DEK ZNF263 JUNB RAB44 RNU1-88P CDKN1A ENSG00000251864 LAP3P2 PPIL1 C6orf89 MTCH1 FGD2 PI16
GH06F037179 1.8 FANTOM5 Ensembl ENCODE 12.9 +488.7 488674 13.4 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B FEZF1 YY1 CBX5 TMEM217 CDKN1A RAB44 RNF8 PIM1 TBC1D22B PIR49359
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAB44 on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB44 Gene

Chromosome:
6
Start:
36,697,827 bp from pter
End:
36,733,183 bp from pter
Size:
35,357 bases
Orientation:
Plus strand

Genomic View for RAB44 Gene

Genes around RAB44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB44 Gene

Proteins for RAB44 Gene

  • Protein details for RAB44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6P3-RAB44_HUMAN
    Recommended name:
    Ras-related protein Rab-44
    Protein Accession:
    Q7Z6P3

    Protein attributes for RAB44 Gene

    Size:
    723 amino acids
    Molecular mass:
    77638 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD92808.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for RAB44 Gene

Post-translational modifications for RAB44 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAB44 Gene

Domains & Families for RAB44 Gene

Gene Families for RAB44 Gene

Protein Domains for RAB44 Gene

Suggested Antigen Peptide Sequences for RAB44 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z6P3

UniProtKB/Swiss-Prot:

RAB44_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB44: view

Function for RAB44 Gene

Gene Ontology (GO) - Molecular Function for RAB44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB44: view

Phenotypes for RAB44 Gene

GenomeRNAi human phenotypes for RAB44:
genes like me logo Genes that share phenotypes with RAB44: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB44 Gene

Localization for RAB44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB44 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB44 gene
Compartment Confidence
plasma membrane 4
lysosome 4

Gene Ontology (GO) - Cellular Components for RAB44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RAB44: view

Pathways & Interactions for RAB44 Gene

genes like me logo Genes that share pathways with RAB44: view

Pathways by source for RAB44 Gene

Interacting Proteins for RAB44 Gene

Gene Ontology (GO) - Biological Process for RAB44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with RAB44: view

No data available for SIGNOR curated interactions for RAB44 Gene

Transcripts for RAB44 Gene

mRNA/cDNA for RAB44 Gene

(10) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB44 Gene

RAB44, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB44 Gene

No ASD Table

Relevant External Links for RAB44 Gene

GeneLoc Exon Structure for
RAB44
ECgene alternative splicing isoforms for
RAB44

Expression for RAB44 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAB44 Gene

mRNA differential expression in normal tissues according to GTEx for RAB44 Gene

This gene is overexpressed in Whole Blood (x17.1).

Protein differential expression in normal tissues from HIPED for RAB44 Gene

This gene is overexpressed in Lavage (33.0), Cerebrospinal fluid (12.6), Monocytes (12.2), and Peripheral blood mononuclear cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAB44 Gene



NURSA nuclear receptor signaling pathways regulating expression of RAB44 Gene:

RAB44

SOURCE GeneReport for Unigene cluster for RAB44 Gene:

Hs.485258
genes like me logo Genes that share expression patterns with RAB44: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RAB44 Gene

Orthologs for RAB44 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB44 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB44 34 35
  • 99.22 (n)
cow
(Bos Taurus)
Mammalia RAB44 34 35
  • 81.3 (n)
dog
(Canis familiaris)
Mammalia RAB44 34 35
  • 80.48 (n)
rat
(Rattus norvegicus)
Mammalia Rab44 34
  • 71.48 (n)
mouse
(Mus musculus)
Mammalia Rab44 34 16 35
  • 68.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RAB44 35
  • 42 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB44 35
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB44 35
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB44 35
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rab44 35
  • 9 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea 4R79.2 35
  • 26 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT52 35
  • 30 (a)
ManyToMany
YPT10 35
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
ManyToMany
Species where no ortholog for RAB44 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RAB44 Gene

ENSEMBL:
Gene Tree for RAB44 (if available)
TreeFam:
Gene Tree for RAB44 (if available)

Paralogs for RAB44 Gene

Variants for RAB44 Gene

Sequence variations from dbSNP and Humsavar for RAB44 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10807172 -- 36,700,106(+) taaga(C/G)aaagt intron-variant, upstream-variant-2KB
rs10947624 -- 36,701,732(+) tgagg(A/G)cccct intron-variant, utr-variant-5-prime
rs111299370 -- 36,724,125(+) CAACA(C/T)TACCA intron-variant
rs111540614 -- 36,731,186(+) TCTTA(C/T)ACACA intron-variant, downstream-variant-500B
rs111801029 -- 36,712,058(+) AGTAC(G/T)TTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB44 Gene

Variant ID Type Subtype PubMed ID
nsv819609 CNV loss 19587683
nsv524053 CNV loss 19592680
nsv1121346 CNV deletion 24896259
nsv1074923 CNV deletion 25765185
nsv1015689 CNV gain 25217958
esv3608711 CNV loss 21293372
esv3571013 CNV loss 25503493
esv3343209 CNV duplication 20981092
esv2731927 CNV deletion 23290073
esv2731922 CNV deletion 23290073
dgv3301n106 CNV deletion 24896259
dgv1002e201 CNV deletion 23290073
dgv1001e201 CNV deletion 23290073

Relevant External Links for RAB44 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB44

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for RAB44 Gene

Disorders for RAB44 Gene

Relevant External Links for RAB44

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB44

No disorders were found for RAB44 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB44 Gene

Publications for RAB44 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  2. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64

Products for RAB44 Gene

Sources for RAB44 Gene

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