Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB43 Gene

protein-coding   GIFtS: 45
GCID: GC03M128806

RAB43, member RAS oncogene family
 Explore 1 disease affiliated with
RAB43 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RAB43    

Aliases
for RAB43 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
RAB43, Member RAS Oncogene Family1 2
RAB411 2 3
RAB11B1 2
Ras-Related Protein Rab-412 3
ISY11
Ras-Related Protein Rab-432

External Ids:    HGNC: 199831   Entrez Gene: 3391222   Ensembl: ENSG000001727807   UniProtKB: Q86YS63   

Export aliases for RAB43 gene to outside databases

Previous GC identifers: GC03M130130 GC03M130128 GC03M130289 GC03M126192


Summaries
for RAB43 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: RAB43_HUMAN, Q86YS6
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of
transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active
GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for
vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL.
Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga
toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the
Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis




Genomic Views
for RAB43 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB43 gene promoter:
         ISGF-3   C/EBPbeta   AML1a   LCR-F1   AP-2gamma   Gfi-1   RORalpha1   CP2   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RAB43 promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB43

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB43


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.3   Ensembl cytogenetic band:  3q21.3   HGNC cytogenetic band: 3q21.3

RAB43 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB43 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M128806:  view genomic region     (about GC identifiers)

Start:
 128,806,412 bp from pter      End:
 128,841,644 bp from pter
Size:
 35,233 bases      Orientation:
 minus strand

Proteins
for RAB43 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RAB43_HUMAN, Q86YS6 (See protein sequence)
Recommended Name: Ras-related protein Rab-43  
Size: 212 amino acids; 23339 Da
Subcellular location: Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor;
Cytoplasmic side (By similarity). Golgi apparatus. Golgi apparatus, trans-Golgi network membrane; Lipid-anchor (By
similarity). Golgi apparatus, trans-Golgi network. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis
1 PDB 3D structure from and Proteopedia for RAB43:
2HUP (3D)    
Secondary accessions: A8K4P9
Alternative splicing: 2 isoforms:  Q86YS6-1   Q9ULR0-1   (Based on a readthrough transcript which may produce a ISY1-RAB43 fusion protein. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAB43: NX_Q86YS6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86YS6

    • RAB43 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (7 alternative transcripts): 
    NP_001191812.1  NP_001191813.1  NP_001191814.1  NP_001191815.1  NP_001191816.1  NP_001191817.1  NP_940892.1  

    ENSEMBL proteins: 
     ENSP00000319781   ENSP00000376981   ENSP00000376985   ENSP00000376984   ENSP00000376982  
     ENSP00000427632   ENSP00000390782  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: RAB43
    OriGene Protein Over-expression Lysate: RAB43
    OriGene Custom Protein Services for RAB43 
    GenScript Custom Purified and Recombinant Proteins Services for RAB43
    Novus Biologicals RAB43 Proteins
    Novus Biologicals RAB43 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RAB43

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IDA17562788
    GO:0005886plasma membrane ----
    GO:0030670phagocytic vesicle membrane IEA--
    GO:0045335phagocytic vesicle IDA--


    RAB43 for ontologies           About GeneDecksing



    RAB43 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RAB43 
    GenScript Custom Superior Antibodies Services for RAB43
    Novus Biologicals RAB43 Antibodies
    Search for Antibodies for RAB43 at Abcam  
    Uscn Antibodies for RAB43
    Search ThermoFisher Antibodies for RAB43

    Assay Products for RAB43: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RAB43
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RAB43

    Protein Domains /
    Families
    for RAB43 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RAB43 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type

    Graphical View of Domain Structure for InterPro Entry Q86YS6

    ProtoNet protein and cluster: Q86YS6

    2 Blocks protein families:
    IPB001806 Transforming protein P21 RAS signature
    IPB002041 GTP-binding nuclear protein Ran


    UniProtKB/Swiss-Prot: RAB43_HUMAN, Q86YS6
    Similarity: Belongs to the small GTPase superfamily. Rab family


    Function
    for RAB43 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RAB43_HUMAN, Q86YS6
    Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of
    transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active
    GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for
    vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL.
    Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga
    toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the
    Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis

    miRNA
    Products:            		 OriGene 3'-UTR Clone: RAB43
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAB43
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB43 (see all 34):
    hsa-miR-4307 hsa-miR-15a hsa-miR-342-3p hsa-miR-507 hsa-miR-105 hsa-miR-4267 hsa-miR-124 hsa-miR-424
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB43 (see all 7)
    OriGene shRNA RFP: RAB43
    OriGene siRNA: RAB43
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB43

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RAB43

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB43 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB43
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 7): RAB43 (NM_198490)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAB43
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB43 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for RAB43
    Search LifeMap BioReagents cell lines for RAB43

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB43

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA17562788
    GO:0005525GTP binding IEA--


    RAB43 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for RAB43:
     G0/1 arrest  Increased G1 DNA content 


    Pathways & Interactions
    for RAB43 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAB43

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for RAB43 (ENSP000003197814) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    GDI2ENSP000003695384STRING: ENSP00000369538
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process IDA17562788
    GO:0007030Golgi organization IMP17684057
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport IEA--
    GO:0035526retrograde transport, plasma membrane to Golgi IMP17562788


    RAB43 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RAB43 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAB43
    Search CenterWatch for drugs/clinical trials and news about RAB43 

    Transcripts
    for RAB43 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RAB43 gene (7 alternative transcripts): 
    NM_001204883.1  NM_001204884.1  NM_001204885.1  NM_001204886.1  NM_001204887.1  NM_001204888.1  NM_198490.2  

    Unigene Clusters for RAB43:

    RAB43, member RAS oncogene family
    Hs.381132  [show with all ESTs], Hs.546542  [show with all ESTs]
    Unigene Representative Sequences: BM917410, NM_001204887
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315150(uc021xdo.1 uc010hsy.2 uc003eln.2) ENST00000393304(uc021xdp.1)
    ENST00000393308(uc021xdq.1) ENST00000393307(uc021xdr.1) ENST00000393305(uc021xds.1)
    ENST00000476465 ENST00000457077

    miRNA
    Products:             		 OriGene 3'-UTR Clone: RAB43
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAB43
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB43 (see all 34):
    hsa-miR-4307 hsa-miR-15a hsa-miR-342-3p hsa-miR-507 hsa-miR-105 hsa-miR-4267 hsa-miR-124 hsa-miR-424
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB43 (see all 7)
    OriGene shRNA RFP: RAB43
    OriGene siRNA: RAB43
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB43
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB43 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB43
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 7): RAB43 (NM_198490)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAB43
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB43 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB43
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAB43
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB43
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB43

    Additional cDNA sequence: 

    AK128345.1 AK291014.1 AY166852.2 BC062319.1 D45418.1 

    9 DOTS entries:

    DT.100038093  DT.120722310  DT.100798218  DT.120862686  DT.120690482  DT.100832508  DT.91991586  DT.92418662 
    DT.120690483 

    24/393 AceView cDNA sequences (see all 393):

    BQ065977 BC004122 BE552209 AI202059 BQ694259 BF312458 CR607147 BU154744 
    AI937413 BU899217 BU739619 BU838746 BE274413 AL043994 BQ227078 AI695849 
    AL603611 BX418603 AW075243 AI940191 BQ675818 BC004442 AI740737 BE550022 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RAB43 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e
    SP1:                                                  -                 -                                       
    SP2:                                                  -     -     -     -                                       
    SP3:                                                  -                                                         
    SP4:                                                  -           -     -                                       
    SP5:                                                        -     -     -                                       


    ECgene alternative splicing isoforms for RAB43

    Expression
    for RAB43 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB43 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAAAGTTGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See RAB43 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAB43

    SOURCE GeneReport for Unigene clusters: Hs.381132 Hs.546542

    UniProtKB/Swiss-Prot: RAB43_HUMAN, Q86YS6
    Tissue specificity: Widely expressed in brain, testis, lung, heart, ovary, colon, kidney, uterus and spleen but not in
    liver

        SABiosciences Custom PCR Arrays for RAB43
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB43
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAB43
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB43
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB43
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB43

    Orthologs
    for RAB43 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RAB43 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RAB431 RAB43, member RAS oncogene family 80.79(n)
    86.67(a)    		   415970  XM_414313.1  XP_414313.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RAB436
    		 --
    		 84(a)
    		 1 ↔ 1
    		 2(159205578-159218719)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.107422 Xenopus laevis transcribed sequence with weak similarity to protein refNP_112243.1 (H.sapiens) small GTP-binding protein [Homo sapiens] less 79.86(n)    CD254745.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1537881 zgc:153788 72.58(n)
    73.89(a)    		   751627  NM_001045347.1  NP_001038812.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Rab-RP31 Rab-related protein 3 62.3(n)
    56.54(a)    		   38930  NM_079246.3  NP_523970.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea rab-191 Protein RAB-19 52.87(n)
    55.67(a)    		   178301  NM_070175.4  NP_502576.1 


    ENSEMBL Gene Tree for RAB43 (if available)
    TreeFam Gene Tree for RAB43 (if available) 

    Paralogs
    for RAB43 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAB43 gene
    RAB102  RAB192  RAB182  RAB262  RAB8A2  RAB372  RAB352  RAB8B2  
    RAB1B2  RAB122  RAB302  RAB1A2  RAB132  
    18/99 SIMAP similar genes for RAB43 using alignment to 3 protein entries:     RAB43_HUMAN (see all proteins) (see all similar genes):
    RAB19    DKFZp686J07132    RAB30    DKFZp686J06205    RAB8A    RAB8B
    rab1b    RAB11B    RAB11A    RAB15    RAB4B    RAB10
    RAB35    RAB13    RAB39B    RAB4A    RAB1C    RAB26

    RAB43 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RAB43
    PGOHUM00000259069


    Genomic Variants
    for RAB43 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/476 NCBI SNPs in RAB43 are shown (see all 476)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1873777691,2
    		--128805938(+) AACACG/TTCTCT 8 -- int1 ds50010--------
    rs1121013691,2
    		--128805982(+) GGGGGG/AAACCT 8 -- int1 ds50011Minor allele frequency- A:0.50CSA 2
    rs76236991,2
    		A,H--128806015(+) TGCCAC/TTGTGG 8 -- int1 ds50014Minor allele frequency- T:0.00NS EA 418
    rs76237101,2
    		A,H--128806035(+) GGCTAC/AAAGAC 8 -- ds5001 int14Minor allele frequency- A:0.00NS EA 418
    rs1175877611,2
    		F,--128806108(+) AGGTCG/AGGGTG 8 -- int1 ds50011Minor allele frequency- A:0.02EA 120
    rs76239031,2
    		C,A,H--128806251(+) GGGTCC/TCCCAA 8 -- int1 ds50015Minor allele frequency- T:0.00NS EA NA 420
    rs1450267621,2
    		--128806309(+) TGGCAA/GGGGGC 8 -- int1 ds50010--------
    rs76357461,2
    		A,H--128806318(+) GCAGCT/ATGTCT 8 -- int1 ds50014Minor allele frequency- A:0.00NS EA 420
    rs76265311,2
    		C,A,H--128806546(+) AGGTGG/ACATGA 8 -- ut316Minor allele frequency- A:0.00NS EA NA 422
    rs1148970461,2
    		F,--128806976(+) TCTTCA/TCTCCC 8 -- ut313Minor allele frequency- T:0.16WA NA EA 358

    HapMap Linkage Disequilibrium report for RAB43 (128806412 - 128841644 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RAB43: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB43
    DNA2.0 Custom Variant and Variant Library Synthesis for RAB43

    Disorders / Diseases
    for RAB43 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RAB43 for disorders           About GeneDecksing

    1 disease for RAB43:    About MalaCards
    herpes simplex


    Export disorders for RAB43 gene to outside databases

    Publications
    for RAB43 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB43 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with RAB43)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, expression pattern of a novel human RAB gene RAB41 and characterization of its intronless homolog RAB41P. (PubMed id 15018353)1, 2, 3 Guo J.H.... Zhao S.Y. (2003)
    2. Rab18 and Rab43 have key roles in ER-Golgi trafficking. (PubMed id 18664496)1, 2 Dejgaard S.Y....Presley J.F. (2008)
    3. Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells. (PubMed id 17684057)1, 2 Haas A.K....Barr F.A. (2007)
    4. Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways. (PubMed id 17562788)1, 2 Fuchs E....Barr F.A. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Analysis of Rab GTPase-activating proteins indicates that Rab1a/b and Rab43 are important for herpes simplex virus 1 secondary envel opment. (PubMed id 21680502)1 Zenner H.L....Crump C.M. (2011)
    8. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PubMed id 21255211)2 Seto S.... Koide Y. (2011)
    9. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    External Searches for RAB43 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RAB43 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 339122 HGNC: 19983 AceView: KIAA1160andRAB43 Ensembl:ENSG00000172780 euGenes: HUgn339122
    ECgene: RAB43 H-InvDB: RAB43

    Other Databases showing RAB43 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RAB43 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB43 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB43 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RAB43 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RAB43 gene:
    Search GeneIP for patents involving RAB43

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for RAB43 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for RAB43  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB43   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB43  
     OriGene Protein Over-expression Lysate for RAB43   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for RAB43   OriGene 3'-UTR Clone for RAB43  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB43   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB43  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for RAB43   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RAB43   OriGene Custom Protein Services for RAB43  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAB43
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB43
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB43
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB43
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB43
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB43
     GenScript Custom Purified and Recombinant Proteins Services for RAB43 GenScript cDNA clones with any tag delivered in your preferred vector for RAB43
     GenScript Custom Assay Services for RAB43 GenScript Custom Superior Antibodies Services for RAB43
     GenScript Custom overexpressing Cell Line Services for RAB43 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RAB43 promoter
     Search Chromatin IP Primers for RAB43
     RT2 qPCR Primer Assay in human, mouse, rat RAB43
     Search GNC Networks for RAB43
     SABiosciences Custom PCR Arrays for RAB43
     Search Tocris compounds for RAB43
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RAB43 antibodies
     RAB43 proteins
     RAB43 lysates
     Search for Antibodies for RAB43 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for RAB43
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     RAB43 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for RAB43
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB43
     Browse SwitchGear 3'UTR luciferase reporter plasmids for RAB43
     SwitchGear Promoter luciferase reporter plasmids for RAB43
     Search ThermoFisher Antibodies for RAB43
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB43
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      RAB43 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4