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Aliases for RAB43 Gene

Aliases for RAB43 Gene

  • RAB43, Member RAS Oncogene Family 2 3 5
  • Ras-Related Protein Rab-41 3 4
  • RAB41 3 4
  • RAB11B 3

External Ids for RAB43 Gene

Previous GeneCards Identifiers for RAB43 Gene

  • GC03M130130
  • GC03M130128
  • GC03M130289
  • GC03M128806
  • GC03M126192

Summaries for RAB43 Gene

GeneCards Summary for RAB43 Gene

RAB43 (RAB43, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are AMPK signaling pathway and Endocytosis. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB33A.

UniProtKB/Swiss-Prot for RAB43 Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB43 Gene

Genomics for RAB43 Gene

Regulatory Elements for RAB43 Gene

Promoters for RAB43 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAB43 on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB43 Gene

Chromosome:
3
Start:
129,087,569 bp from pter
End:
129,122,801 bp from pter
Size:
35,233 bases
Orientation:
Minus strand

Genomic View for RAB43 Gene

Genes around RAB43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB43 Gene

Proteins for RAB43 Gene

  • Protein details for RAB43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YS6-RAB43_HUMAN
    Recommended name:
    Ras-related protein Rab-43
    Protein Accession:
    Q86YS6
    Secondary Accessions:
    • A8K4P9
    • E9PBQ0

    Protein attributes for RAB43 Gene

    Size:
    212 amino acids
    Molecular mass:
    23339 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RAB43 Gene

    Alternative splice isoforms for RAB43 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB43 Gene

Proteomics data for RAB43 Gene at MOPED

Post-translational modifications for RAB43 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAB43 Gene

Domains & Families for RAB43 Gene

Gene Families for RAB43 Gene

Suggested Antigen Peptide Sequences for RAB43 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86YS6

UniProtKB/Swiss-Prot:

RAB43_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB43: view

Function for RAB43 Gene

Molecular function for RAB43 Gene

UniProtKB/Swiss-Prot Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.
genes like me logo Genes that share phenotypes with RAB43: view

Animal Models for RAB43 Gene

MGI Knock Outs for RAB43:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB43 Gene

Localization for RAB43 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB43 Gene

Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane; Lipid-anchor. Golgi apparatus, trans-Golgi network. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000269 PubMed:21255211}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB43 Gene COMPARTMENTS Subcellular localization image for RAB43 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endosome 3

Gene Ontology (GO) - Cellular Components for RAB43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA --
genes like me logo Genes that share ontologies with RAB43: view

Pathways & Interactions for RAB43 Gene

genes like me logo Genes that share pathways with RAB43: view

Interacting Proteins for RAB43 Gene

Gene Ontology (GO) - Biological Process for RAB43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization IMP 17684057
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:1901998 toxin transport IEA --
genes like me logo Genes that share ontologies with RAB43: view

No data available for SIGNOR curated interactions for RAB43 Gene

Drugs & Compounds for RAB43 Gene

No Compound Related Data Available

Transcripts for RAB43 Gene

Unigene Clusters for RAB43 Gene

RAB43, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB43 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e
SP1: - -
SP2: - - - -
SP3: -
SP4: - - -
SP5: - - -
SP6:

Relevant External Links for RAB43 Gene

GeneLoc Exon Structure for
RAB43
ECgene alternative splicing isoforms for
RAB43

Expression for RAB43 Gene

mRNA expression in normal human tissues for RAB43 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB43 Gene

This gene is overexpressed in Whole Blood (x9.3) and Liver (x4.5).

Protein differential expression in normal tissues from HIPED for RAB43 Gene

This gene is overexpressed in Testis (15.2), Uterus (13.2), Skin (11.5), and Fetal ovary (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB43 Gene



SOURCE GeneReport for Unigene cluster for RAB43 Gene Hs.381132

mRNA Expression by UniProt/SwissProt for RAB43 Gene

Q86YS6-RAB43_HUMAN
Tissue specificity: Widely expressed in brain, testis, lung, heart, ovary, colon, kidney, uterus and spleen but not in liver.
genes like me logo Genes that share expression patterns with RAB43: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for RAB43 Gene

Orthologs for RAB43 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB43 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 31 (a)
ManyToMany
RAB43 35
  • 99.53 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia RAB43 35
  • 91.51 (n)
  • 94.34 (a)
RAB43 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab43 16
Rab43 36
  • 91 (a)
OneToOne
Rab43 35
  • 89.67 (n)
  • 92.5 (a)
oppossum
(Monodelphis domestica)
Mammalia RAB43 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB43 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab43 35
  • 89.67 (n)
  • 93 (a)
chicken
(Gallus gallus)
Aves RAB43 35
  • 81 (n)
  • 87 (a)
RAB43 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB43 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10742 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.77 35
zebrafish
(Danio rerio)
Actinopterygii RAB43 36
  • 72 (a)
OneToOne
zgc:153788 35
  • 72.67 (n)
  • 74 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007096 35
  • 65.52 (n)
  • 61.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab-RP3 36
  • 51 (a)
OneToMany
Rab19 35
  • 62.39 (n)
  • 57.75 (a)
worm
(Caenorhabditis elegans)
Secernentea rab-19 35
  • 53.83 (n)
  • 57.75 (a)
rab-19 36
  • 53 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for RAB43:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB43 Gene

ENSEMBL:
Gene Tree for RAB43 (if available)
TreeFam:
Gene Tree for RAB43 (if available)

Paralogs for RAB43 Gene

Pseudogenes.org Pseudogenes for RAB43 Gene

genes like me logo Genes that share paralogs with RAB43: view

Variants for RAB43 Gene

Structural Variations from Database of Genomic Variants (DGV) for RAB43 Gene

Variant ID Type Subtype PubMed ID
dgv5251n71 CNV Loss 21882294
dgv5252n71 CNV Loss 21882294
nsv877471 CNV Loss 21882294
dgv5253n71 CNV Gain+Loss 21882294
nsv433217 CNV Loss 18776910

Variation tolerance for RAB43 Gene

Residual Variation Intolerance Score: 67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB43 Gene

HapMap Linkage Disequilibrium report
RAB43

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RAB43 Gene

Disorders for RAB43 Gene

Relevant External Links for RAB43

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB43

No disorders were found for RAB43 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB43 Gene

Publications for RAB43 Gene

  1. Isolation, expression pattern of a novel human RAB gene RAB41 and characterization of its intronless homolog RAB41P. (PMID: 15018353) Guo J.H. … Zhao S.Y. (DNA Seq. 2003) 2 3 4 67
  2. Rab18 and a Rab18 GEF complex are required for normal ER structure. (PMID: 24891604) Gerondopoulos A. … Barr F.A. (J. Cell Biol. 2014) 3
  3. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3
  4. Toxoplasma gondii salvages sphingolipids from the host Golgi through the rerouting of selected Rab vesicles to the parasitophorous vacuole. (PMID: 23615442) Romano J.D. … Coppens I. (Mol. Biol. Cell 2013) 3
  5. Structural basis of myosin V Rab GTPase-dependent cargo recognition. (PMID: 24248336) Pylypenko O. … Houdusse A.M. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3

Products for RAB43 Gene

Sources for RAB43 Gene

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