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RAB42 Gene

protein-coding GIFtS: 43

GC01P028791

RAB42, member RAS oncogene family
(Previous names: RAB42, member RAS homolog family )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
MGC45806 ^¹, ²
OTTHUMP00000003787 ^²
RP4-669K10.6 ^²

Descriptions
RAB42, member RAS homolog family ^¹, ²
RAB42, member RAS oncogene family ^²

External Ids
HGNC: 28702¹
Entrez Gene: 115273²
UniProtKB: Q8N4Z0³
Ensembl: ENSG00000188060⁷

Search outside databases for aliases for RAB42 gene

Previous GC identifers: GC00U906277 GC14U900439 GC01P028740

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RAB42 gene

Entrez Gene cytogenetic band: 1p35.3 Ensembl cytogenetic band: 1p35.3 HGNC cytogenetic band: 1p35.3

RAB42 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P028791: (about GC identifiers)

Start:	28,791,299 bp from pter
End:	28,793,685 bp from pter
Size:	2,387 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_004610.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RAB42_HUMAN, Q8N4Z0 (See protein sequence)

Recommended Name: Putative Ras-related protein Rab-42

Size: 105 amino acids; 11364 Da

Subcellular location: Membrane; Lipid-anchor (Potential)

Caution: Could be the product of a pseudogene. N-terminally truncated compared to paralogs

REFSEQ proteins: NP_689517.1

ENSEMBL proteins:

ENSP00000362932 ENSP00000373941

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (RAB42)
	Human Recombinant Proteins from Abnova (RAB42)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--

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Antibodies for RAB42:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for RAB42
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (RAB42), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (RAB42)
	Novus Biologicals Antibodies for RAB42

Assays for RAB42:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q8N4Z0

ProtoNet protein and cluster: Q8N4Z0

UniProtKB/Swiss-Prot: RAB42_HUMAN, Q8N4Z0

Similarity: Belongs to the small GTPase superfamily. Rab family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RAB42)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RAB42)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152304

Applied Biosystems Silencer® siRNAs for RAB42

Sigma-Aldrich siRNA for RAB42

Sigma-Aldrich shRNA for RAB42

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for RAB42
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_152304
Myc/DDK tagged cDNA clone in CMV expression vector: NM_152304
untagged cDNA clones in CMV expression vector (see all 2): NM_152304

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_152304

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005525	GTP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007264	small GTPase mediated signal transduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Enzo Life Sciences drugs & compounds for RAB42

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RAB42

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RAB42)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RAB42)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152304

Sigma-Aldrich siRNA for RAB42

Sigma-Aldrich shRNA for RAB42

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_152304

REFSEQ mRNAs for RAB42 gene:

NM_152304.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_152304

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_152304
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_152304
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_152304

Additional cDNA sequence:

AK312176.1 BC033175.1

1 DOTS entry:

DT.99999320

24/25 AceView cDNA sequences (see all 25 ):

BQ896758 NM_152304 AA305473 W02785 BC033175 BX110464 BE077107 CD367526

BE272632 CB127053 BG421668 BI084093 BE272568 BG324330 BX328155 AW732439

BG249062 BF748782 BX388808 AK026009 W30925 BX363431 BF753134 BG324239

highest scoring ESTs for RAB42:

BC033175 BG324330 AW732439 BG324239 BI084093 BU162527 NM_152304 BG249062 BI084888 BX328155

Unigene Cluster for RAB42:

RAB42, member RAS oncogene family

Hs.652321 [show with all ESTs]

Unigene Representative Sequence: BU162527

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000373826 ENST00000389290

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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RAB42 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RAB42

¹ / ²

1 probe-set matching RAB42 gene

	Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
	Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
	1552846_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.652321

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for RAB42 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RAB42P¹	--	RAB42, member RAS oncogene family, pseudogene	87.62(n) 83.81(a)	487331 XM_544457.1 XP_544457.1
chimpanzee (Pan troglodytes)	LOC469251¹	--	similar to RAB42, member RAS oncogene family	99.68(n) 99.05(a)	469251 XM_524636.2 XP_524636.2
cow (Bos taurus)	RAB42¹	--	similar to RAB42, member RAS homolog family	84.76(n) 80(a)	514286 XM_592115.3 XP_592115.2
mouse (Mus musculus)	9530096D07Rik¹	--	RIKEN cDNA 9530096D07 gene	81.73(n) 75(a)	242681 NM_001081651.1 NP_001075120.1

About this table Species with no ortholog for RAB42

ENSEMBL Gene Tree for RAB42

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for RAB42 gene

RAB33B² RAB33A²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/14 NCBI SNPs in RAB42 are shown (see all 14 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 6)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs11800899^1,2	A,C,H	28791114(+)	`AGGCCG/AGGGCT`	1	--	ng5¹		1		EU	120
--	rs4654341^1,2	A	28793786(+)	`ccttgA/Caggga`	1	--	ng3¹		0	--	--	--	--
--	rs12065373^1,2	H	28793182(+)	`CCCCAG/ACAGGA`	1	N/S	mis¹ ese³		4		EU EA WA	406
--	rs12123931^1,2	A	28791579(+)	`AAAACC/GGCCGC`	1	--	int¹		0	--	--	--	--
--	rs4654310^1,2	--	28790506(+)	`ctgggC/Tgacag`	1	--	ng5¹		0	--	--	--	--
--	rs9426285^1,2	--	28789842(+)	`tgagaC/Tggagt`	1	--	ng5¹		0	--	--	--	--
--	rs55870041^1,2	--	28793344(+)	`CATGCC/TTCCTG`	1	--	ut3¹		0	--	--	--	--
--	rs55964616^1,2	--	28794014(+)	`TGGAGA/GCTTCT`	1	--	ng3¹		0	--	--	--	--
--	rs61786025^1,2	--	28792268(+)	`AGTCAC/TGCTTG`	1	--	int¹		0	--	--	--	--
--	rs71727670^1,2	--	28792321(+)	`TTTTG-/TAGACG`	1	--	int¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for RAB42 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

3 PubMed articles for RAB42 gene:

The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 115273	HGNC: 28702	AceView: MGC45806	Ensembl:ENSG00000188060	euGenes: HUgn115273
ECgene: RAB42	H-InvDB: RAB42

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for RAB42	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for RAB42
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for RAB42:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RAB42-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RAB42		Antibodies for RAB42
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for RAB42		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (RAB42)
	Antibodies (RAB42)
	Chimera RNAi (RAB42)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (RAB42)
	Antibodies (RAB42)

Search OriGene for RAB42

Search Tocris compounds for RAB42

	Drugs for RAB42
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for RAB42

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RAB42 Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for RAB42

Summaries
for RAB42

Genomic Location
for RAB42

Proteins
for RAB42

Protein Domains/
Families
for RAB42

Gene Function
for RAB42

Pathways & Interactions
for RAB42

Drugs & Compounds
for RAB42

Transcripts
for RAB42

Expression
for RAB42

Orthologs
for RAB42

Paralogs
for RAB42

SNPs/Variants
for RAB42

Disorders & Mutations
for RAB42

Medical News
for RAB42

Publications
for RAB42

Search for RAB42

Genome Databases showing RAB42

Other Databases showing RAB42

Specialized Databases showing RAB42

Licensable Technologies
for RAB42

Services
for RAB42

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RAB42 Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor RAB42

Summariesfor RAB42

Genomic Locationfor RAB42

Proteinsfor RAB42

Protein Domains/Familiesfor RAB42

Gene Functionfor RAB42

Pathways & Interactionsfor RAB42

Drugs & Compoundsfor RAB42

Transcriptsfor RAB42

Expression for RAB42

Orthologsfor RAB42

Paralogsfor RAB42

SNPs/Variantsfor RAB42

Disorders & Mutationsfor RAB42

Medical Newsfor RAB42

Publicationsfor RAB42

Search for RAB42

Genome Databases showing RAB42

Other Databases showing RAB42

Specialized Databases showing RAB42

Licensable Technologiesfor RAB42

Servicesfor RAB42

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RAB42

Summaries
for RAB42

Genomic Location
for RAB42

Proteins
for RAB42

Protein Domains/
Families
for RAB42

Gene Function
for RAB42

Pathways & Interactions
for RAB42

Drugs & Compounds
for RAB42

Transcripts
for RAB42

Expression
for RAB42

Orthologs
for RAB42

Paralogs
for RAB42

SNPs/Variants
for RAB42

Disorders & Mutations
for RAB42

Medical News
for RAB42

Publications
for RAB42

Licensable Technologies
for RAB42

Services
for RAB42