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Aliases for RAB42 Gene

Aliases for RAB42 Gene

  • RAB42, Member RAS Oncogene Family 2 3 5
  • RAB42, Member RAS Homolog Family 2

External Ids for RAB42 Gene

Previous GeneCards Identifiers for RAB42 Gene

  • GC00U906277
  • GC14U900439
  • GC01P028740
  • GC01P028791
  • GC01P028918
  • GC01P027171

Summaries for RAB42 Gene

GeneCards Summary for RAB42 Gene

RAB42 (RAB42, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are RAB geranylgeranylation and Metabolism of proteins. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB39B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB42 Gene

Genomics for RAB42 Gene

Regulatory Elements for RAB42 Gene

Enhancers for RAB42 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G028881 2 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +293.0 293043 6.8 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 TRNAU1AP SNHG12 GMEB1 PHACTR4 TMEM200B ENSG00000237934 SNORA73B SNHG3 RAB42 DNAJC8
GH01G028171 2 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -417.8 -417800 6.4 HDGF FOXA2 PKNOX1 CREB3L1 ARNT WRNIP1 FEZF1 YBX1 ZNF766 ZNF143 PTAFR GMEB1 THEMIS2 SNHG12 TRNAU1AP ACTG1P20 WASF2 NPM1P39 PHACTR4 SNORA73B
GH01G028320 1.5 ENCODE dbSUPER 10.6 -269.2 -269172 5.2 CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC PHACTR4 ACTG1P20 GMEB1 SNHG12 ENSG00000237934 ENSG00000231344 TRNAU1AP WASF2 SNORA73B RAB42
GH01G029236 1.4 FANTOM5 ENCODE 10.5 +646.5 646515 5.1 HDGF FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 CBX5 ZNF207 TRNAU1AP SNHG12 TMEM200B PHACTR4 GMEB1 SNORA73B RAB42 SNHG3 ENSG00000237934 PTPRU
GH01G028551 1.2 ENCODE 11.9 -39.0 -39030 2.5 CREB3L1 YBX1 DMAP1 YY1 SLC30A9 ZNF143 SP3 TBX21 MEF2D ZNF610 PRDX3P2 SNORD99 SNORA61 SNORA73B RCC1 SNHG3 PHACTR4 RAB42 DNAJC8 TRNAU1AP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAB42 on UCSC Golden Path with GeneCards custom track

Promoters for RAB42 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000003888 400 1200 ELF3 TBP ARID4B FEZF1 DNMT3B ZNF48 RARA GATA4 MIXL1 THAP11

Genomic Location for RAB42 Gene

Chromosome:
1
Start:
28,592,200 bp from pter
End:
28,595,443 bp from pter
Size:
3,244 bases
Orientation:
Plus strand

Genomic View for RAB42 Gene

Genes around RAB42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB42 Gene

Proteins for RAB42 Gene

  • Protein details for RAB42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4Z0-RAB42_HUMAN
    Recommended name:
    Putative Ras-related protein Rab-42
    Protein Accession:
    Q8N4Z0
    Secondary Accessions:
    • B2R5G2

    Protein attributes for RAB42 Gene

    Size:
    105 amino acids
    Molecular mass:
    11364 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RAB42 Gene

Post-translational modifications for RAB42 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB42 Gene

No data available for DME Specific Peptides for RAB42 Gene

Domains & Families for RAB42 Gene

Gene Families for RAB42 Gene

Protein Domains for RAB42 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RAB42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4Z0

UniProtKB/Swiss-Prot:

RAB42_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB42: view

Function for RAB42 Gene

Gene Ontology (GO) - Molecular Function for RAB42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB42: view

Phenotypes for RAB42 Gene

genes like me logo Genes that share phenotypes with RAB42: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAB42

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB42 Gene

Localization for RAB42 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB42 Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB42 gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for RAB42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RAB42: view

Pathways & Interactions for RAB42 Gene

genes like me logo Genes that share pathways with RAB42: view

Pathways by source for RAB42 Gene

Gene Ontology (GO) - Biological Process for RAB42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with RAB42: view

No data available for SIGNOR curated interactions for RAB42 Gene

Drugs & Compounds for RAB42 Gene

No Compound Related Data Available

Transcripts for RAB42 Gene

mRNA/cDNA for RAB42 Gene

Unigene Clusters for RAB42 Gene

RAB42, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAB42

Alternative Splicing Database (ASD) splice patterns (SP) for RAB42 Gene

No ASD Table

Relevant External Links for RAB42 Gene

GeneLoc Exon Structure for
RAB42
ECgene alternative splicing isoforms for
RAB42

Expression for RAB42 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB42 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAB42 Gene



NURSA nuclear receptor signaling pathways regulating expression of RAB42 Gene:

RAB42

SOURCE GeneReport for Unigene cluster for RAB42 Gene:

Hs.652321

Evidence on tissue expression from TISSUES for RAB42 Gene

  • Kidney(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with RAB42: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB42 Gene

Orthologs for RAB42 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB42 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB42 34 35
  • 99.85 (n)
dog
(Canis familiaris)
Mammalia RAB42 34 35
  • 88.84 (n)
cow
(Bos Taurus)
Mammalia RAB42 34 35
  • 86.85 (n)
mouse
(Mus musculus)
Mammalia Rab42 34 16 35
  • 83.72 (n)
oppossum
(Monodelphis domestica)
Mammalia RAB42 35
  • 30 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB42 35
  • 22 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rab42a 35
  • 18 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rab39 35
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rab-39 35
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 18 (a)
OneToMany
Species where no ortholog for RAB42 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RAB42 Gene

ENSEMBL:
Gene Tree for RAB42 (if available)
TreeFam:
Gene Tree for RAB42 (if available)

Paralogs for RAB42 Gene

(23) SIMAP similar genes for RAB42 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RAB42: view

Variants for RAB42 Gene

Sequence variations from dbSNP and Humsavar for RAB42 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000066869 -- 28,592,950(+) TCCCA(A/G)AGACC intron-variant
rs1000544409 -- 28,594,799(+) TGGCT(A/G)CGATG intron-variant, utr-variant-3-prime
rs1000669088 -- 28,591,002(+) GTGAG(C/T)CACTG upstream-variant-2KB
rs1001145277 -- 28,590,868(+) AGCAC(A/G)TGCCA upstream-variant-2KB
rs1001994341 -- 28,591,368(+) AGGTT(G/T)CAGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RAB42 Gene

Variant ID Type Subtype PubMed ID
nsv545916 CNV gain 21841781

Variation tolerance for RAB42 Gene

Residual Variation Intolerance Score: 57.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB42 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB42

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB42 Gene

Disorders for RAB42 Gene

Relevant External Links for RAB42

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB42

No disorders were found for RAB42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB42 Gene

Publications for RAB42 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for RAB42 Gene

  • Addgene plasmids for RAB42

Sources for RAB42 Gene

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