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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RAB42 Gene

protein-coding GIFtS: 38
GCID: GC01P028918

RAB42, member RAS oncogene family

(Previous names: RAB42, member RAS homolog family )

Search for RAB42
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
RAB42, Member RAS Oncogene Family¹ ²
RAB42, Member RAS Homolog Family¹ ²
MGC45806¹
RP4-669K10.6²
Putative Ras-Related Protein Rab-42²

External Ids:	HGNC: 28702¹	Entrez Gene: 115273²	Ensembl: ENSG00000188060⁷	UniProtKB: Q8N4Z0³

Export aliases for RAB42 gene to outside databases

Previous GC identifers: GC00U906277 GC14U900439 GC01P028740 GC01P028791 GC01P027171

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004610.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RAB42 gene promoter:
GR AML1a GR-beta Meis-1b AREB6 SEF-1 (1) Meis-1a GR-alpha TGIF Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RAB42 promoter sequence

Search SABiosciences Chromatin IP Primers for RAB42

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB42

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.3 Ensembl cytogenetic band: 1p35.3 HGNC cytogenetic band: 1p35.3

RAB42 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB42 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P028918: view genomic region (about GC identifiers)

Start:	28,918,712 bp from pter	End:	28,921,955 bp from pter
Size:	3,244 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RAB42_HUMAN, Q8N4Z0 (See protein sequence)

Recommended Name: Putative Ras-related protein Rab-42

Size: 105 amino acids; 11364 Da

Subcellular location: Membrane; Lipid-anchor (Potential)

Caution: Could be the product of a pseudogene. N-terminally truncated compared to paralogs

Secondary accessions: B2R5G2

Explore the universe of human proteins at neXtProt for RAB42: NX_Q8N4Z0

RAB42 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001180461.1 NP_689517.1

ENSEMBL proteins:

ENSP00000362932

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--

RAB42 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RAB42 for domains About GeneDecksing

1 InterPro domain/family:

IPR001806 Small_GTPase

Graphical View of Domain Structure for InterPro Entry Q8N4Z0

ProtoNet protein and cluster: Q8N4Z0

UniProtKB/Swiss-Prot: RAB42_HUMAN, Q8N4Z0

Similarity: Belongs to the small GTPase superfamily. Rab family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005525	GTP binding	IEA	--

RAB42 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RAB42

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007264	small GTPase mediated signal transduction	IEA	--

RAB42 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for RAB42 gene (2 alternative transcripts):

NM_001193532.1 NM_152304.1

Unigene Cluster for RAB42:

RAB42, member RAS oncogene family

Hs.652321 [show with all ESTs]

Unigene Representative Sequence: NM_001193532

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000373826(uc001bqu.3 uc001bqv.3) ENST00000465518

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Additional cDNA sequence:

AK312176.1 BC033175.1

2 DOTS entries:

DT.99999320 DT.97846714

24/25 AceView cDNA sequences (see all 25):

W02785 BQ896758 NM_152304 BC033175 BX110464 AA305473 BE077107 BE272632

CD367526 CB127053 BG421668 BE272568 BI084093 BG324330 BX328155 AW732439

BG249062 BX388808 BF748782 AK026009 W30925 BX363431 BF753134 BX350554

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RAB42 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

RAB42 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Metencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RAB42 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAB42

SOURCE GeneReport for Unigene cluster: Hs.652321

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for RAB42 gene from 1/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rab42^{1 , 5}	RAB42, member RAS oncogene family, pseudogene⁵ RAB42, member RAS oncogene family¹	83.72(n)¹ 79.53(a)¹		4 (65.14 cM)⁵ 242681¹ NM_001081651.1¹ NP_001075120.1¹ 132302197⁵

ENSEMBL Gene Tree for RAB42 (if available)
TreeFam Gene Tree for RAB42 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RAB42 gene

RAB39A² RAB2A² RAB25² RAB14² RAB4B² RAB39B² RAB11B² RAB4A²

RAB11A² RAB2B²

18/24 SIMAP similar genes for RAB42 using alignment to 1 protein entry: RAB42_HUMAN(see all similar genes):

RAB37 RAB13 RAB26 RAB2A RAB17 RAB2B

DKFZp313C1541 HRAS DKFZp547A0616 RAB6C RALB KRAS

RAB11A RAB31 RAB3C RAB6B RAB27A RAB11B

RAB42 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143762693^1,2		--	28917146(+)	`TTTGAC/TGGAAT`	2	--	us2k¹		0	--	--	--	--
rs189818611^1,2		--	28917172(+)	`TGAACA/GGCACT`	2	--	us2k¹		0	--	--	--	--
rs79904076^1,2		--	28917185(+)	`CCCACT/ATTCAT`	2	--	us2k¹		1		EA	120
rs181942458^1,2		--	28917197(+)	`AATTCA/GTCTAG`	2	--	us2k¹		0	--	--	--	--
rs114292217^1,2	F,	--	28917244(+)	`TTATTT/ATTTTT`	2	--	us2k¹		1		WA	118
rs9426285^1,2	C,	--	28917255(+)	`tgagaT/Cggagt`	2	--	us2k¹		1		NA	2
rs141103075^1,2		--	28917288(+)	`AGTGCA/GGTGGC`	2	--	us2k¹		0	--	--	--	--
rs146885144^1,2		--	28917294(+)	`GTGGCA/GCAATC`	2	--	us2k¹		0	--	--	--	--
rs186156721^1,2		--	28917393(+)	`ATGCCC/TGACTA`	2	--	us2k¹		0	--	--	--	--
rs137932752^1,2		--	28917548(+)	`CAAGCG/TCTGAG`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RAB42 (28918712 - 28921955 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RAB42: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RAB42 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RAB42)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 115273	HGNC: 28702	AceView: MGC45806	Ensembl:ENSG00000188060	euGenes: HUgn115273
ECgene: RAB42	H-InvDB: RAB42

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RAB42	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RAB42	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RAB42 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RAB42 gene:
Search GeneIP for patents involving RAB42

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB42

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	SwitchGear Promoter luciferase reporter plasmids for RAB42

Search ThermoFisher Antibodies for RAB42

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB42

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Hot genes Disease genes RAB42 gene at Home site.

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RAB42 Gene

RAB42, member RAS oncogene family

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RAB42 Gene

RAB42, member RAS oncogene family

Aliasesfor RAB42 gene

Summariesfor RAB42 gene

Genomic Viewsfor RAB42 gene

Proteinsfor RAB42 gene

Protein Domains /Familiesfor RAB42 gene

Functionfor RAB42 gene

Pathways & Interactionsfor RAB42 gene

Drugs & Compoundsfor RAB42 gene

Transcriptsfor RAB42 gene

Expression for RAB42 gene

Orthologsfor RAB42 gene

Paralogsfor RAB42 gene

Genomic Variantsfor RAB42 gene

Disorders / Diseasesfor RAB42 gene

Publicationsfor RAB42 gene

External Searches for RAB42 gene

Genome Databases showing RAB42 gene

Other Databases showing RAB42 gene

Specialized Databases showing RAB42 gene

Intellectual Propertyfor RAB42 gene

Productsfor RAB42 gene

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Aliases
for RAB42 gene

Summaries
for RAB42 gene

Genomic Views
for RAB42 gene

Proteins
for RAB42 gene

Protein Domains /
Families
for RAB42 gene

Function
for RAB42 gene

Pathways & Interactions
for RAB42 gene

Drugs & Compounds
for RAB42 gene

Transcripts
for RAB42 gene

Expression
for RAB42 gene

Orthologs
for RAB42 gene

Paralogs
for RAB42 gene

Genomic Variants
for RAB42 gene

Disorders / Diseases
for RAB42 gene

Publications
for RAB42 gene

Intellectual Property
for RAB42 gene

Products
for RAB42 gene