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Aliases for RAB42 Gene

Aliases for RAB42 Gene

  • RAB42, Member RAS Oncogene Family 2 3 5
  • RAB42, Member RAS Homolog Family 2

External Ids for RAB42 Gene

Previous GeneCards Identifiers for RAB42 Gene

  • GC00U906277
  • GC14U900439
  • GC01P028740
  • GC01P028791
  • GC01P028918
  • GC01P027171

Summaries for RAB42 Gene

GeneCards Summary for RAB42 Gene

RAB42 (RAB42, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Metabolism of proteins. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB39A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB42 Gene

Genomics for RAB42 Gene

Regulatory Elements for RAB42 Gene

Enhancers for RAB42 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F028551 0.4 ENCODE 11.9 -39.0 -39030 2.5 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 CBX5 PRDX3P2 SNORA61 SNORD99 SNORA73B RCC1 SNHG3 PHACTR4 RAB42 GMEB1 ENSG00000237934
GH01F028487 0.6 FANTOM5 11.4 -104.6 -104642 0.4 BCOR ZMYM3 ATF2 PHACTR4 SNORA73B PRDX3P2 RAB42 SNORA61 SNORD99 TRNAU1AP EYA3 RNU6ATAC27P SNHG3
GH01F028579 0.6 ENCODE 10.9 -11.0 -11000 4.5 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 PHACTR4 GMEB1 SNHG12 TMEM200B TRNAU1AP SNORA73B ENSG00000237934 ENSG00000231344 SNHG3 LINC01756
GH01F028647 0.6 ENCODE 10.7 +56.2 56246 2.7 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC GMEB1 PHACTR4 SNHG12 ENSG00000237934 TRNAU1AP SNORA73B ENSG00000231344 TMEM200B SNHG3 LINC01756
GH01F028320 0.2 ENCODE 10.6 -269.2 -269172 5.2 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 PHACTR4 GMEB1 ENSG00000237934 SNHG12 ACTG1P20 TMEM200B ENSG00000231344 TRNAU1AP SNORA73B TAF12
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RAB42 on UCSC Golden Path with GeneCards custom track

Promoters for RAB42 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000533528 500 1801 ELF3 TBP ZFP64 ARID4B FEZF1 ZNF48 DNMT3B RARA GATA4 MIXL1

Genomic Location for RAB42 Gene

Chromosome:
1
Start:
28,592,200 bp from pter
End:
28,595,443 bp from pter
Size:
3,244 bases
Orientation:
Plus strand

Genomic View for RAB42 Gene

Genes around RAB42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB42 Gene

Proteins for RAB42 Gene

  • Protein details for RAB42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4Z0-RAB42_HUMAN
    Recommended name:
    Putative Ras-related protein Rab-42
    Protein Accession:
    Q8N4Z0
    Secondary Accessions:
    • B2R5G2

    Protein attributes for RAB42 Gene

    Size:
    105 amino acids
    Molecular mass:
    11364 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RAB42 Gene

Post-translational modifications for RAB42 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB42 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB42 Gene

Domains & Families for RAB42 Gene

Gene Families for RAB42 Gene

Protein Domains for RAB42 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RAB42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4Z0

UniProtKB/Swiss-Prot:

RAB42_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB42: view

Function for RAB42 Gene

Gene Ontology (GO) - Molecular Function for RAB42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB42: view

Phenotypes for RAB42 Gene

genes like me logo Genes that share phenotypes with RAB42: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB42 Gene

Localization for RAB42 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB42 Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB42 Gene COMPARTMENTS Subcellular localization image for RAB42 gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for RAB42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RAB42: view

Pathways & Interactions for RAB42 Gene

genes like me logo Genes that share pathways with RAB42: view

Pathways by source for RAB42 Gene

Interacting Proteins for RAB42 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000362932%0d%0a9606.ENSP00000284957%0d%0a9606.ENSP00000398177%0d%0a9606.ENSP00000369461%0d%0a9606.ENSP00000377665%0d%0a9606.ENSP00000302530%0d%0a
Selected Interacting proteins: ENSP00000362932 Q8N4Z0-RAB42_HUMAN for RAB42 Gene via STRING IID

Gene Ontology (GO) - Biological Process for RAB42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with RAB42: view

No data available for SIGNOR curated interactions for RAB42 Gene

Transcripts for RAB42 Gene

mRNA/cDNA for RAB42 Gene

Unigene Clusters for RAB42 Gene

RAB42, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB42 Gene

No ASD Table

Relevant External Links for RAB42 Gene

GeneLoc Exon Structure for
RAB42
ECgene alternative splicing isoforms for
RAB42

Expression for RAB42 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAB42 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAB42 Gene



NURSA nuclear receptor signaling pathways regulating expression of RAB42 Gene:

RAB42

SOURCE GeneReport for Unigene cluster for RAB42 Gene:

Hs.652321
genes like me logo Genes that share expression patterns with RAB42: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RAB42 Gene

Orthologs for RAB42 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB42 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB42 34 35
  • 99.85 (n)
dog
(Canis familiaris)
Mammalia RAB42 34 35
  • 88.84 (n)
cow
(Bos Taurus)
Mammalia RAB42 34 35
  • 86.85 (n)
mouse
(Mus musculus)
Mammalia Rab42 34 16 35
  • 83.72 (n)
oppossum
(Monodelphis domestica)
Mammalia RAB42 35
  • 30 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB42 35
  • 22 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rab42a 35
  • 18 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rab39 35
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rab-39 35
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 18 (a)
OneToMany
Species where no ortholog for RAB42 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RAB42 Gene

ENSEMBL:
Gene Tree for RAB42 (if available)
TreeFam:
Gene Tree for RAB42 (if available)

Paralogs for RAB42 Gene

(23) SIMAP similar genes for RAB42 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RAB42: view

Variants for RAB42 Gene

Sequence variations from dbSNP and Humsavar for RAB42 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111269144 -- 28,592,468(+) CGGGG(C/G)GCGGA intron-variant, upstream-variant-2KB
rs111894928 -- 28,593,849(+) CCACA(A/C/G)GAGTG reference, missense
rs111917411 -- 28,595,088(+) CCACT(A/G)TGATG utr-variant-3-prime
rs114292217 -- 28,590,732(+) TTATT(A/T)TTTTT upstream-variant-2KB
rs115343456 -- 28,593,067(+) TGGAA(A/G)GGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB42 Gene

Variant ID Type Subtype PubMed ID
nsv545916 CNV gain 21841781

Variation tolerance for RAB42 Gene

Residual Variation Intolerance Score: 57.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB42 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB42

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB42 Gene

Disorders for RAB42 Gene

Relevant External Links for RAB42

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB42

No disorders were found for RAB42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB42 Gene

Publications for RAB42 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for RAB42 Gene

Sources for RAB42 Gene

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