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Aliases for RAB41 Gene

Aliases for RAB41 Gene

  • RAB41, Member RAS Oncogene Family 2 3 5
  • RAB41, Member RAS Homolog Family 2

External Ids for RAB41 Gene

Previous GeneCards Identifiers for RAB41 Gene

  • GC00U991172
  • GC0XP068369
  • GC0XP069285
  • GC0XP069418
  • GC0XP069502
  • GC0XP063322

Summaries for RAB41 Gene

Entrez Gene Summary for RAB41 Gene

  • This gene encodes a small GTP-binding protein that belongs to the largest family within the Ras superfamily. These proteins function as regulators of membrane trafficking. They cycle between inactive GDP-bound and activated GTP-bound states, which is controlled by GTP hydrolysis-activating proteins (GAPs). This family member can be activated by the GAP protein RN-Tre, and it is localized to the Golgi complex. [provided by RefSeq, May 2010]

GeneCards Summary for RAB41 Gene

RAB41 (RAB41, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Vesicle-mediated transport. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB6B.

UniProtKB/Swiss-Prot for RAB41 Gene

  • Required for normal Golgi ribbon organization and ER-to-Golgi trafficking.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB41 Gene

Genomics for RAB41 Gene

Regulatory Elements for RAB41 Gene

Enhancers for RAB41 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RAB41 on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB41 Gene

70,281,391 bp from pter
70,285,800 bp from pter
4,410 bases
Plus strand

Genomic View for RAB41 Gene

Genes around RAB41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB41 Gene

Proteins for RAB41 Gene

  • Protein details for RAB41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-41
    Protein Accession:
    Secondary Accessions:
    • Q17RQ0

    Protein attributes for RAB41 Gene

    222 amino acids
    Molecular mass:
    25038 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI41489.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RAB41 Gene


neXtProt entry for RAB41 Gene

Proteomics data for RAB41 Gene at MOPED

Post-translational modifications for RAB41 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB41 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for RAB41
  • Santa Cruz Biotechnology (SCBT) Antibodies for RAB41

No data available for DME Specific Peptides for RAB41 Gene

Domains & Families for RAB41 Gene

Gene Families for RAB41 Gene

Protein Domains for RAB41 Gene

Suggested Antigen Peptide Sequences for RAB41 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB41: view

Function for RAB41 Gene

Molecular function for RAB41 Gene

UniProtKB/Swiss-Prot Function:
Required for normal Golgi ribbon organization and ER-to-Golgi trafficking.
genes like me logo Genes that share phenotypes with RAB41: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB41 Gene

Localization for RAB41 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB41 Gene

Cytoplasm. Note=punctate localization concentrated in ruffled regions at the cell periphery.

Subcellular locations from

Jensen Localization Image for RAB41 Gene COMPARTMENTS Subcellular localization image for RAB41 gene
Compartment Confidence
cytosol 3
golgi apparatus 3
nucleus 2
cytoskeleton 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RAB41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with RAB41: view

Pathways & Interactions for RAB41 Gene

genes like me logo Genes that share pathways with RAB41: view

Pathways by source for RAB41 Gene

Gene Ontology (GO) - Biological Process for RAB41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
GO:0042147 retrograde transport, endosome to Golgi IBA --
genes like me logo Genes that share ontologies with RAB41: view

No data available for SIGNOR curated interactions for RAB41 Gene

Drugs & Compounds for RAB41 Gene

No Compound Related Data Available

Transcripts for RAB41 Gene

mRNA/cDNA for RAB41 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB41 Gene

RAB41, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB41 Gene

No ASD Table

Relevant External Links for RAB41 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB41 Gene

mRNA expression in normal human tissues for RAB41 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB41 Gene

This gene is overexpressed in Testis (x5.2).

Protein differential expression in normal tissues from HIPED for RAB41 Gene

This gene is overexpressed in Brain (57.8) and Urine (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAB41 Gene

SOURCE GeneReport for Unigene cluster for RAB41 Gene Hs.276327

mRNA Expression by UniProt/SwissProt for RAB41 Gene

Tissue specificity: Widely expressed in brain, testis, lung, heart, ovary, colon, kidney, uterus and spleen but not in liver.
genes like me logo Genes that share expression patterns with RAB41: view

Protein tissue co-expression partners for RAB41 Gene

- Elite partner

Primer Products

Orthologs for RAB41 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB41 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAB41 35
  • 99.25 (n)
  • 98.64 (a)
RAB41 36
  • 99 (a)
(Danio rerio)
Actinopterygii zgc:63637 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab6 36
  • 64 (a)
(Caenorhabditis elegans)
Secernentea rab-6.2 36
  • 62 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT6 36
  • 51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10389 36
  • 64 (a)
Species with no ortholog for RAB41:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RAB41 Gene

Gene Tree for RAB41 (if available)
Gene Tree for RAB41 (if available)

Paralogs for RAB41 Gene

Paralogs for RAB41 Gene

genes like me logo Genes that share paralogs with RAB41: view

Variants for RAB41 Gene

Sequence variations from dbSNP and Humsavar for RAB41 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747812906 -- 70,284,355(+) GCTGG(A/G)GTAGG intron-variant, reference, synonymous-codon
rs747843403 -- 70,284,380(+) AGAAG(A/G)TAAGT intron-variant, reference, missense
rs748630818 -- 70,283,923(+) CTGGC(C/T)CTTTT intron-variant
rs748823170 -- 70,284,250(+) CCATT(-/CA)CACAC intron-variant
rs748933625 -- 70,284,230(+) CCCTT(G/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB41 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
nsv525258 CNV Gain 19592680

Variation tolerance for RAB41 Gene

Residual Variation Intolerance Score: 55.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.42% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RAB41 Gene

Disorders for RAB41 Gene

Relevant External Links for RAB41

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RAB41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB41 Gene

Publications for RAB41 Gene

  1. Rab41 is a novel regulator of Golgi apparatus organization that is needed for ER-to-Golgi trafficking and cell growth. (PMID: 23936529) Liu S. … Storrie B. (PLoS ONE 2013) 3 4 67
  2. Evolution of the Rab family of small GTP-binding proteins. (PMID: 11697911) Pereira-Leal J.B. … Seabra M.C. (J. Mol. Biol. 2001) 2 3
  3. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3

Products for RAB41 Gene

Sources for RAB41 Gene