V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

RAB41 Gene

protein-coding   GIFtS: 38

GC0XP069418
RAB41, member RAS oncogene family
(Previous names: RAB41, member RAS homolog family )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Descriptions
RAB41, member RAS homolog family 1, 2
RAB41, member RAS oncogene family 2
External Ids
HGNC: 182931
Entrez Gene: 3475172
UniProtKB: Q5JT253
Ensembl: ENSG000001471277
Search outside databases for aliases for RAB41 gene

Previous GC identifers: GC00U991172 GC0XP068369 GC0XP069285

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RAB41 gene  

Entrez Gene cytogenetic band: Xq13.1   Ensembl cytogenetic band:  Xq13.1   HGNC cytogenetic band: Xq13.1

RAB41 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP069418:     (about GC identifiers)

Start:
69,418,793 bp from pter
End:
69,421,577 bp from pter
Size:
2,785 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000023.9  NT_011669.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: RAB41_HUMAN, Q5JT25 (See protein sequence)
Recommended Name: Ras-related protein Rab-41  
Size: 222 amino acids; 25038 Da
Secondary accessions: Q17RQ0
Alternative splicing: 2 isoforms:  Q5JT25-1   Q5JT25-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001027898.1  

    ENSEMBL proteins: 
    ENSP00000363597 ENSP00000276066 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                  OriGene Purified Recombinant Human Protein: RAB41 


    Antibodies for RAB41: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for RAB41
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for RAB41

    Assays for RAB41: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5 InterPro domains/families:
     IPR015600 Rab6-like
     IPR001806 Ras_GTPase
     IPR005225 Small_GTP_bd
     IPR003579 GTPase_Rab
     IPR013753 Ras


       GeneDecks  RAB41 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q5JT25

    ProtoNet protein and cluster: Q5JT25

    UniProtKB/Swiss-Prot: RAB41_HUMAN, Q5JT25
    Similarity: Belongs to the small GTPase superfamily. Rab family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB41)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_293398

                  Applied Biosystems Silencer® siRNAs for RAB41

                  Sigma-Aldrich siRNA for RAB41  
                         Sigma-Aldrich shRNA for RAB41  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001032726
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001032726
                                     untagged cDNA clone in CMV expression vector: NM_001032726 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001032726

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0005525 GTP binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264 small GTPase mediated signal transduction IEA--
    GO:0015031 protein transport IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for RAB41
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for RAB41

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB41)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_293398

                  Sigma-Aldrich siRNA for RAB41  
                         Sigma-Aldrich shRNA for RAB41  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001032726  

    REFSEQ mRNAs for RAB41 gene: 

    NM_001032726.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001032726  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001032726
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001032726
                                     untagged cDNA clone in CMV expression vector: NM_001032726 

    Additional cDNA sequence: 

    BC117239.1 BC143888.1 

    2 DOTS entries:

    DT.75149660  DT.99957168 

    4 AceView cDNA sequences:

    BM931597 BQ638192 BM931699 AI126463 

    highest scoring ESTs for RAB41:

    AI126463 BM931597 BM931699 BQ638192 BC117239 BM684045 BQ877160 DB036502 NM_001032726 BU679329 

    Unigene Cluster for RAB41:

    RAB41, member RAS oncogene family
    Hs.276327  [show with all ESTs]
    Unigene Representative Sequence: NM_001032726


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000374473  ENST00000276066  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    RAB41 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for RAB41

    1Data from GNF BioGPS
        About these images

    About these images

    CGAP SAGE TAG: GCCACTTACT

    SOURCE GeneReport for Unigene cluster: Hs.276327
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    ENSEMBL Gene Tree for RAB41
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for RAB41 gene
    RAB202  RAB212  RAB6C2  RAB6A2  RAB6B2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/13 NCBI SNPs in RAB41 are shown (see all 13 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 26)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr X posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs11994711,2
    C,F,H69421394(-) TAGCTG/ATGAGA 1 -- ut31 ese311Minor allele frequency- A:0.16NS EU EA WA NA 543
    rs59809111,2
    C,F,H69421512(+) GCCAAT/AACAAT 1 -- ut31 ese34Minor allele frequency- A:0.01EU EA WA 376
    rs22754101,2
    F,H69421489(-) TCAGCT/GGCTGT 1 -- ut31 ese34Minor allele frequency- G:0.02EU EA WA 418
    rs22978731,2
    H69420159(-) CATGAT/CGACAA 1 V/I mis14Minor allele frequency- C:0.00EU EA WA 402
    rs22754111,2
    F,H69420855(-) GAAGCC/GACACG 1 V/V syn1 ese34Minor allele frequency- G:0.02EU EA WA 418
    --
    rs125564891,2
    A,C,F,H69420803(+) TCCCCG/TTTTTT 1 -- int1 trp34Minor allele frequency- T:0.24EU EA WA 418
    --
    rs16264691,2
    C,F,H69419204(-) AAGAGC/TGGCAA 1 -- int14Minor allele frequency- T:0.03EU EA WA 410
    rs22754121,2
    C,F,H69420798(-) AGGGGG/AAAAAA 1 -- int1 trp33Minor allele frequency- A:0.27EA WA 298
    rs11994721,2
    H69421091(-) AGCTTC/TTAGGA 1 -- int17Minor allele frequency- T:0.00EU EA WA NA 466
    --
    rs17137461,2
    F69419203(-) AGAGTG/AGCAAA 1 -- int13Minor allele frequency- A:0.10NA EA 252
    About this table

    HapMap Linkage Disequilibrium images for RAB41 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    4 PubMed articles for RAB41 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 347517 HGNC: 18293 AceView: RAB41 Ensembl:ENSG00000147127 euGenes: HUgn347517
    ECgene: RAB41 H-InvDB: RAB41
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for RAB41 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for RAB41:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for RAB41-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for RAB41 Antibodies for RAB41
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for RAB41 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Search for Recombinant Proteins
     Search for Antibodies
     Search for Chimera RNAi
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Search for Recombinant Proteins
     Search for Antibodies
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for RAB41




     Drugs for RAB41
     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for RAB41

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    RAB41 Gene at Home site.
    Version 2.41.1
    server5.xennexinc.com