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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RAB41 Gene

protein-coding GIFtS: 40
GCID: GC0XP069502

RAB41, member RAS oncogene family

(Previous names: RAB41, member RAS homolog family )

Explore 1 disease affiliated with
RAB41 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
RAB41, Member RAS Oncogene Family¹ ²
RAB41, Member RAS Homolog Family¹ ²
Ras-Related Protein Rab-41²

External Ids:	HGNC: 18293¹	Entrez Gene: 347517²	Ensembl: ENSG00000147127⁷	UniProtKB: Q5JT25³

Export aliases for RAB41 gene to outside databases

Previous GC identifers: GC00U991172 GC0XP068369 GC0XP069285 GC0XP069418 GC0XP063322

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAB41:

This gene encodes a small GTP-binding protein that belongs to the largest family within the Ras superfamily. These

proteins function as regulators of membrane trafficking. They cycle between inactive GDP-bound and activated GTP-bound

states, which is controlled by GTP hydrolysis-activating proteins (GAPs). This family member can be activated by the

GAP protein RN-Tre, and it is localized to the Golgi complex. (provided by RefSeq, May 2010)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_011669.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RAB41 gene promoter:
AP-2alpha isoform 3 AP-2alpha isoform 2 Tal-1beta E47 Hand1 ARP-1 AP-2alpha isoform 4 AP-2alpha ITF-2 AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RAB41 promoter sequence

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB41

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.1 Ensembl cytogenetic band: Xq13.1 HGNC cytogenetic band: Xq13.1

RAB41 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB41 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP069502: view genomic region (about GC identifiers)

Start:	69,501,943 bp from pter	End:	69,504,852 bp from pter
Size:	2,910 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RAB41_HUMAN, Q5JT25 (See protein sequence)

Recommended Name: Ras-related protein Rab-41

Size: 222 amino acids; 25038 Da

Sequence caution: Sequence=CAI41489.1; Type=Erroneous initiation;

Secondary accessions: Q17RQ0

Alternative splicing: 2 isoforms: Q5JT25-1 Q5JT25-2

Explore the universe of human proteins at neXtProt for RAB41: NX_Q5JT25

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5JT25

RAB41 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001027898.2

ENSEMBL proteins:

ENSP00000421643 ENSP00000363597 ENSP00000276066

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RAB41 for domains About GeneDecksing

3 InterPro domains/families:

IPR005225 Small_GTP-bd_dom

IPR001806 Small_GTPase

IPR003579 Small_GTPase_Rab_type

Graphical View of Domain Structure for InterPro Entry Q5JT25

ProtoNet protein and cluster: Q5JT25

UniProtKB/Swiss-Prot: RAB41_HUMAN, Q5JT25

Similarity: Belongs to the small GTPase superfamily. Rab family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005525	GTP binding	IEA	--

RAB41 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for RAB41:

Increased gamma-H2AX phosphory

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RAB41

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007264	small GTPase mediated signal transduction	IEA	--
GO:0015031	protein transport	IEA	--

RAB41 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RAB41
Search CenterWatch for drugs/clinical trials and news about RAB41

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for RAB41 gene:

NM_001032726.2

Unigene Cluster for RAB41:

RAB41, member RAS oncogene family

Hs.276327 [show with all ESTs]

Unigene Representative Sequence: NM_001032726

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000509895 ENST00000374473 ENST00000276066(uc010nkv.3)

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Additional cDNA sequence:

BC117239.1 BC143888.1

2 DOTS entries:

DT.75149660 DT.99957168

4 AceView cDNA sequences:

BM931597 BQ638192 BM931699 AI126463

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RAB41 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCACTTACT

About this image
See RAB41 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.276327

SABiosciences Custom PCR Arrays for RAB41

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB41 gene from 7/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F1NPD6_CHICK⁶	RAB6A, member RAS oncogene family	60(a)	1 ↔ 1	1(200443728-200502907)
lizard (Anolis carolinensis)	Reptilia	--	--	72(a)	1 ↔ 1	AAWZ02038411(231-10350)
zebrafish (Danio rerio)	Actinopterygii	zgc:63637⁶	zgc:63637	61(a)	1 ↔ 1	14(34255704-34272304)
fruit fly (Drosophila melanogaster)	Insecta	Rab6⁶	Rab-protein 6	63(a)	1 → many	2L(12107287-12109124)
worm (Caenorhabditis elegans)	Secernentea	rab-6.2⁶ rab-6.1⁶	Ras-related protein Rab-6.1	61(a) 60(a)	1 ↔ many possible ortholog	X(17222401-17224503) III(9004703-9005880)
thale cress (Arabidopsis thaliana)	eudicotyledons	AtRABH1e⁶ ATRAB6⁶ (see all 5)	RAB GTPase-like protein H1D (see all 5)	56(a) 56(a) (see all 5)	many ↔ many many ↔ many (see all 5)	5(3219991-3221515) 2(9466444-9467688)
rice (Oryza sativa)	Liliopsida	-- --	ras-related protein, putative, expressed	56(a) 50(a)	many ↔ many many ↔ many	7(18577846-18581871) 3(4762758-4765371)

ENSEMBL Gene Tree for RAB41 (if available)
TreeFam Gene Tree for RAB41 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RAB41 gene

RAB6C² RAB6A² RAB28² RAB6B²

18/77 SIMAP similar genes for RAB41 using alignment to 2 protein entries: RAB41_HUMAN (see all proteins) (see all similar genes):

RAB6B RAB6A' RAB6A RAB6C RAB17 RAB5C

RAB39B RAB3A RAB3C RAB7A RAB8B RAB11B

RAB12 RAB44 DKFZp313C1541 RAB13 RAB14 RAB25

RAB41 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs148602544^1,2		--	69502290(+)	`GGAAAC/GATTGG`	1	--	int¹		0	--	--	--	--
rs143189037^1,2		--	69502292(+)	`AAAGAC/TTGGAG`	1	--	int¹		0	--	--	--	--
rs146258911^1,2		--	69502413(+)	`CTTCAC/TGTACA`	2	T M	mis¹		0	--	--	--	--
rs1713746^1,2	C,	--	69502478(-)	`AGAGTG/AGCAAA`	1	--	int¹		4		NA EA WA	254
rs1626469^1,2	C,F,H,	--	69502479(-)	`AAGAGC/TGGCAA`	1	--	int¹		12		NS EA WA NA CSA	424
rs150983246^1,2		--	69502486(+)	`TCTTCC/TTGGCG`	1	--	int¹		0	--	--	--	--
rs140845620^1,2		--	69502616(+)	`AATAGA/TGGGAA`	1	--	int¹		0	--	--	--	--
rs192757082^1,2		--	69503185(+)	`CATTCA/GTGATT`	2	H R	mis¹		0	--	--	--	--
rs61752445^1,2	C	--	69503221(+)	`CATTAC/TAAGTG`	2	T I	mis¹		0	--	--	--	--
rs150006000^1,2		--	69503285(+)	`GATTGA/CCAAAA`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RAB41 (69501943 - 69504852 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RAB41: --
Locus Specific Mutation Databases (LSDB): RAB41

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RAB41 for disorders About GeneDecksing

1 disease for RAB41: About MalaCards

malaria

Export disorders for RAB41 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RAB41 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RAB41)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
Evolution of the Rab family of small GTP-binding proteins. (PubMed id 11697911)^{1, 3} Pereira-Leal J.B. and Seabra M.C. (2001)
A GTPase-activating protein controls Rab5 function in endocytic trafficking. (PubMed id 16086013)¹ Haas A.K....Barr F.A. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 347517	HGNC: 18293	AceView: RAB41	Ensembl:ENSG00000147127	euGenes: HUgn347517
ECgene: RAB41	H-InvDB: RAB41

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RAB41	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RAB41	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RAB41 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RAB41 gene:
Search GeneIP for patents involving RAB41

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RAB41 gene at Home site.

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RAB41 Gene

RAB41, member RAS oncogene family

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RAB41 Gene

RAB41, member RAS oncogene family

Aliasesfor RAB41 gene

Summariesfor RAB41 gene

Genomic Viewsfor RAB41 gene

Proteinsfor RAB41 gene

Protein Domains /Familiesfor RAB41 gene

Functionfor RAB41 gene

Pathways & Interactionsfor RAB41 gene

Drugs & Compoundsfor RAB41 gene

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Expression for RAB41 gene

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Genomic Variantsfor RAB41 gene

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Publicationsfor RAB41 gene

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Genome Databases showing RAB41 gene

Other Databases showing RAB41 gene

Specialized Databases showing RAB41 gene

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Productsfor RAB41 gene

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Aliases
for RAB41 gene

Summaries
for RAB41 gene

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for RAB41 gene

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for RAB41 gene

Protein Domains /
Families
for RAB41 gene

Function
for RAB41 gene

Pathways & Interactions
for RAB41 gene

Drugs & Compounds
for RAB41 gene

Transcripts
for RAB41 gene

Expression
for RAB41 gene

Orthologs
for RAB41 gene

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for RAB41 gene

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for RAB41 gene

Disorders / Diseases
for RAB41 gene

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for RAB41 gene

Intellectual Property
for RAB41 gene

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for RAB41 gene