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Aliases for RAB41 Gene

Aliases for RAB41 Gene

  • RAB41, Member RAS Oncogene Family 2 3
  • RAB41, Member RAS Homolog Family 2

External Ids for RAB41 Gene

Previous GeneCards Identifiers for RAB41 Gene

  • GC00U991172
  • GC0XP068369
  • GC0XP069285
  • GC0XP069418
  • GC0XP069502
  • GC0XP063322

Summaries for RAB41 Gene

Entrez Gene Summary for RAB41 Gene

  • This gene encodes a small GTP-binding protein that belongs to the largest family within the Ras superfamily. These proteins function as regulators of membrane trafficking. They cycle between inactive GDP-bound and activated GTP-bound states, which is controlled by GTP hydrolysis-activating proteins (GAPs). This family member can be activated by the GAP protein RN-Tre, and it is localized to the Golgi complex. [provided by RefSeq, May 2010]

GeneCards Summary for RAB41 Gene

RAB41 (RAB41, Member RAS Oncogene Family) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB6C.

UniProtKB/Swiss-Prot for RAB41 Gene

  • Required for normal Golgi ribbon organization and ER-to-Golgi trafficking.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB41 Gene

Genomics for RAB41 Gene

Genomic Location for RAB41 Gene

Start:
70,282,093 bp from pter
End:
70,285,002 bp from pter
Size:
2,910 bases
Orientation:
Plus strand

Genomic View for RAB41 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB41 Gene

Proteins for RAB41 Gene

  • Protein details for RAB41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JT25-RAB41_HUMAN
    Recommended name:
    Ras-related protein Rab-41
    Protein Accession:
    Q5JT25
    Secondary Accessions:
    • Q17RQ0

    Protein attributes for RAB41 Gene

    Size:
    222 amino acids
    Molecular mass:
    25038 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI41489.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RAB41 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB41 Gene

Proteomics data for RAB41 Gene at MOPED

Post-translational modifications for RAB41 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB41 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB41 Gene

Domains for RAB41 Gene

Gene Families for RAB41 Gene

HGNC:
  • RAB :RAB, member RAS oncogene

Protein Domains for RAB41 Gene

Suggested Antigen Peptide Sequences for RAB41 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JT25

UniProtKB/Swiss-Prot:

RAB41_HUMAN :
  • Q5JT25
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB41: view

Function for RAB41 Gene

Molecular function for RAB41 Gene

UniProtKB/Swiss-Prot Function: Required for normal Golgi ribbon organization and ER-to-Golgi trafficking.

Gene Ontology (GO) - Molecular Function for RAB41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB41: view

Phenotypes for RAB41 Gene

GenomeRNAi human phenotypes for RAB41:
genes like me logo Genes that share phenotypes with RAB41: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB41

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RAB41 Gene

Localization for RAB41 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB41 Gene

Cytoplasm. Note=punctate localization concentrated in ruffled regions at the cell periphery.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB41 Gene COMPARTMENTS Subcellular localization image for RAB41 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
endosome 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RAB41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005794 Golgi apparatus IBA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RAB41: view

Pathways for RAB41 Gene

SuperPathways for RAB41 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RAB41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IBA --
GO:0006891 intra-Golgi vesicle-mediated transport IBA --
GO:0006913 nucleocytoplasmic transport --
genes like me logo Genes that share ontologies with RAB41: view

No data available for Pathways by source for RAB41 Gene

Transcripts for RAB41 Gene

mRNA/cDNA for RAB41 Gene

(3) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB41 Gene

RAB41, member RAS oncogene family:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB41

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB41 Gene

No ASD Table

Relevant External Links for RAB41 Gene

GeneLoc Exon Structure for
RAB41
ECgene alternative splicing isoforms for
RAB41

Expression for RAB41 Gene

mRNA expression in normal human tissues for RAB41 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB41 Gene

This gene is overexpressed in Testis (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RAB41 Gene

SOURCE GeneReport for Unigene cluster for RAB41 Gene Hs.276327

mRNA Expression by UniProt/SwissProt for RAB41 Gene

Q5JT25-RAB41_HUMAN
Tissue specificity: Widely expressed in brain, testis, lung, heart, ovary, colon, kidney, uterus and spleen but not in liver.
genes like me logo Genes that share expressions with RAB41: view

In Situ Assay Products

Orthologs for RAB41 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB41 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB41 35
  • 99.25 (n)
  • 98.64 (a)
RAB41 36
  • 99 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:63637 36
  • 62 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Rab6 36
  • 64 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rab-6.2 36
  • 62 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT6 36
  • 51 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10389 36
  • 64 (a)
OneToMany
Species with no ortholog for RAB41:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RAB41 Gene

ENSEMBL:
Gene Tree for RAB41 (if available)
TreeFam:
Gene Tree for RAB41 (if available)

Paralogs for RAB41 Gene

Paralogs for RAB41 Gene

genes like me logo Genes that share paralogs with RAB41: view

Variants for RAB41 Gene

Sequence variations from dbSNP and Humsavar for RAB41 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1199471 -- 70,284,819(-) TAGCT(A/G)TGAGA utr-variant-3-prime
rs1199472 -- 70,284,516(-) AGCTT(C/T)TAGGA intron-variant
rs1626469 -- 70,282,629(-) AAGAG(C/T)GGCAA intron-variant
rs1713746 -- 70,282,628(-) AGAGT(A/G)GCAAA intron-variant
rs2275410 -- 70,284,914(-) TCAGC(G/T)GCTGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RAB41 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
nsv525258 CNV Gain 19592680

Relevant External Links for RAB41 Gene

HapMap Linkage Disequilibrium report
RAB41
Locus Specific Mutation Databases (LSDB)
RAB41

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB41 Gene

Disorders for RAB41 Gene

No disorders were found for RAB41 Gene.

No data available for UniProtKB/Swiss-Prot for RAB41 Gene

Publications for RAB41 Gene

  1. Evolution of the Rab family of small GTP-binding proteins. (PMID: 11697911) Pereira-Leal J.B. … Seabra M.C. (J. Mol. Biol. 2001) 2 3
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  3. Rab41 is a novel regulator of Golgi apparatus organization that is needed for ER-to-Golgi trafficking and cell growth. (PMID: 23936529) Liu S. … Storrie B. (PLoS ONE 2013) 3 4
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Isolation, expression pattern of a novel human RAB gene RAB41 and characterization of its intronless homolog RAB41P. (PMID: 15018353) Guo J.H. … Zhao S.Y. (DNA Seq. 2003) 4

Products for RAB41 Gene

Sources for RAB41 Gene

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