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Aliases & Descriptions for RAB40C
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| OTTHUMP00000045523 2 | | RARL 1, 2, 3 | | RASL8C 2, 3 |
| | | Descriptions |
|---|
| RAB40C, member RAS oncogene family 2 | | RAR (RAS like GTPASE) like 2 | | RAR like 2 | | RAS-like GTPase 2 | | RAS-like, family 8, member C 1, 2 | | Rar-like protein 3 | | Ras-like protein family member 8C 3 | | SOCS box-containing protein RAR3 3 |
|
| | Search outside databases for aliases for RAB40C genePrevious GC identifer: GC16P000659 |
Summaries for RAB40C(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: RB40C_HUMAN, Q96S21Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins |
Genomic Location for RAB40C
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RAB40C gene 
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3RAB40C Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P000580:
(about GC identifiers)
Start:
|
580,177 bp from pter |
End:
|
619,273 bp from pter |
Size:
|
39,097 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000016.8 NT_037887.4
| Proteins for RAB40C
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RB40C_HUMAN, Q96S21 (See
protein sequence)Recommended Name: Ras-related protein Rab-40C Size: 281 amino acids; 31304 Da
Subunit: Component of the probable SCF-like ECS(RAB40C) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and RAB40C. Interacts with CUL5, RNF7, TCEB1 and TCEB2
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions: O60795 Q4TT41REFSEQ proteins: NP_066991.2
ENSEMBL proteins: ENSP00000248139
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | About this table
Antibodies for RAB40C: Assays for RAB40C: | Protein
Domains/ Families for RAB40C(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q96S21
ProtoNet protein and cluster: Q96S21 2 Blocks protein families: IPB001496 SOCS protein IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: RB40C_HUMAN, Q96S21Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)Similarity: Belongs to the small GTPase superfamily. Rab familySimilarity: Contains 1 SOCS box domain | Gene Function for RAB40C
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021168
Applied Biosystems Silencer® siRNAs for RAB40C
Sigma-Aldrich siRNA and siRNA Panels for RAB40C  Sigma-Aldrich shRNA for RAB40C  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_021168                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_021168                                  untagged cDNA clones in CMV expression vector (see all 2): NM_021168 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_021168
UniProtKB/Swiss-Prot: RB40C_HUMAN, Q96S21Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0005525 | GTP binding |
IEA | -- | About this table | Pathways & Interactions for RAB40C
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| UniProtKB/Swiss-Prot: RB40C_HUMAN, Q96S21Pathway: Protein modification; protein ubiquitination 2 Interacting proteins for RAB40C (Q96S212) via UniProtKB, MINT, and/or STRINGAbout this table
3 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- | | GO:0019941 | modification-dependent protein catabolic process |
IEA | -- | About this table
|
Drugs & Compounds for RAB40C(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for RAB40C |
Browse Tocris compounds for RAB40C
|
Transcripts for RAB40C(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021168
Sigma-Aldrich siRNA and siRNA Panels for RAB40C  Sigma-Aldrich shRNA for RAB40C  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_021168 REFSEQ mRNAs for RAB40C gene: NM_021168.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_021168               OriGene GFP tagged cDNA clone in CMV expression vector: NM_021168                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_021168                                  untagged cDNA clones in CMV expression vector (see all 2): NM_021168  Additional cDNA sequence: AK000584.1 AY823398.1 BC001581.1 BC014531.2 BC028696.1 17 DOTS entries: DT.95083922 DT.453980 DT.97840659 DT.100802005 DT.100802002 DT.92033462 DT.100682161 DT.86844847 DT.91765872 DT.91765870 DT.95155374 DT.40308091 DT.120687829 DT.91988367 DT.92019726 DT.95155363 DT.97765902 24/243 AceView cDNA sequences (see all 243
):BM052895 AW166046 BQ061135 BQ233405 BX282685 AI819096 AI307130 BF116146 BF593711 AA514649 BQ287791 BF813406 BM997982 BX383974 BE621282 NM_053284 CD674470 AW516749 AW005486 BU619004 BU527649 BM664879 AI160282 BM702333
highest scoring ESTs for RAB40C:AI935153 AW007215 AA027001 AA057882 AA079092 AA292788 AA341497 AA394175 AA431384 AA432378 Unigene Cluster for RAB40C: RAB40C, member RAS oncogene family Hs.459630 [show with all ESTs]Unigene Representative Sequence: BC028696
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RAB40C (see all 7
)
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | · | 7d | |
| SP1: | |   | - |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | - |   | |   | - |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | - |   | |   | - |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | - |   | - |   | - |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for RAB40C
1 Ensembl transcript including schematic representation: ENST00000248139
|
Expression for RAB40C
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RAB40C expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RAB40C
1 / 2 / 3 6 probe-sets matching RAB40C gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AACTACCAGA
SOURCE GeneReport for Unigene cluster: Hs.459630
Expression variation in blood from EXPOLDB for RAB40C |
Orthologs for RAB40C
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB40C gene from 5/9 species (see all 9
)
About this table Species with no ortholog for RAB40C
ENSEMBL Gene Tree for RAB40C | Paralogs for RAB40C(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RAB40C gene
- RAB40A2 RAB40B2 RAB40AL2
|
SNPs/Variants for RAB40C(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RAB40C (up to first 250kb)
|
Disorders & Mutations for RAB40C
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for RAB40C(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RAB40C (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 8 PubMed articles for RAB40C gene: |
Search for RAB40C
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RAB40C
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RAB40C
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB40C(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RAB40C(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RAB40C:

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| | | | Search Tocris compounds for RAB40C |
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Incremental update: 13 Oct 2009
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