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Aliases for RAB40C Gene

Aliases for RAB40C Gene

  • RAB40C, Member RAS Oncogene Family 2 3 5
  • Ras-Like Protein Family Member 8C 3 4
  • SOCS Box-Containing Protein RAR3 3 4
  • RAS-Like, Family 8, Member C 2 3
  • Rar-Like Protein 3 4
  • RASL8C 3 4
  • RARL 3 4
  • RAR (RAS Like GTPASE) Like 3
  • Ras-Like GTPase 3
  • RAR Like 3

External Ids for RAB40C Gene

Previous HGNC Symbols for RAB40C Gene

  • RASL8C

Previous GeneCards Identifiers for RAB40C Gene

  • GC16P000659
  • GC16P000580
  • GC16P000561
  • GC16P000657
  • GC16P000664
  • GC16P000669
  • GC16P000672
  • GC16P000675
  • GC16P000677
  • GC16P000684

Summaries for RAB40C Gene

GeneCards Summary for RAB40C Gene

RAB40C (RAB40C, Member RAS Oncogene Family) is a Protein Coding gene. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB33A.

UniProtKB/Swiss-Prot for RAB40C Gene

  • Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB40C Gene

Genomics for RAB40C Gene

Regulatory Elements for RAB40C Gene

Enhancers for RAB40C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RAB40C on UCSC Golden Path with GeneCards custom track

Promoters for RAB40C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAB40C on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB40C Gene

589,357 bp from pter
629,273 bp from pter
39,917 bases
Plus strand

Genomic View for RAB40C Gene

Genes around RAB40C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB40C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB40C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB40C Gene

Proteins for RAB40C Gene

  • Protein details for RAB40C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-40C
    Protein Accession:
    Secondary Accessions:
    • A2IDE2
    • D3DU54
    • O60795
    • Q4TT41
    • Q5PXE8
    • Q6PIU5

    Protein attributes for RAB40C Gene

    281 amino acids
    Molecular mass:
    31304 Da
    Quaternary structure:
    • Component of the probable SCF-like ECS(RAB40C) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and RAB40C. Interacts with CUL5, RNF7, TCEB1 and TCEB2.

    Alternative splice isoforms for RAB40C Gene


neXtProt entry for RAB40C Gene

Proteomics data for RAB40C Gene at MOPED

Post-translational modifications for RAB40C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAB40C Gene

Domains & Families for RAB40C Gene

Gene Families for RAB40C Gene

Suggested Antigen Peptide Sequences for RAB40C Gene

Graphical View of Domain Structure for InterPro Entry



  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Belongs to the small GTPase superfamily. Rab family.
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Contains 1 SOCS box domain.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB40C: view

Function for RAB40C Gene

Molecular function for RAB40C Gene

UniProtKB/Swiss-Prot Function:
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
genes like me logo Genes that share phenotypes with RAB40C: view

Animal Models for RAB40C Gene

MGI Knock Outs for RAB40C:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB40C Gene

Localization for RAB40C Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB40C Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for RAB40C Gene COMPARTMENTS Subcellular localization image for RAB40C gene
Compartment Confidence
cytosol 3
plasma membrane 3
extracellular 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for RAB40C Gene

Pathways & Interactions for RAB40C Gene

SuperPathways for RAB40C Gene

No Data Available

UniProtKB/Swiss-Prot Q96S21-RB40C_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RAB40C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with RAB40C: view

No data available for Pathways by source and SIGNOR curated interactions for RAB40C Gene

Drugs & Compounds for RAB40C Gene

No Compound Related Data Available

Transcripts for RAB40C Gene

Unigene Clusters for RAB40C Gene

RAB40C, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB40C Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - -
SP6: - - -

Relevant External Links for RAB40C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB40C Gene

mRNA expression in normal human tissues for RAB40C Gene

Protein differential expression in normal tissues from HIPED for RAB40C Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (61.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAB40C Gene

SOURCE GeneReport for Unigene cluster for RAB40C Gene Hs.459630

genes like me logo Genes that share expression patterns with RAB40C: view

Protein tissue co-expression partners for RAB40C Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAB40C Gene

Orthologs for RAB40C Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB40C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RAB40C 35
  • 92.76 (n)
  • 99.64 (a)
RAB40C 36
  • 100 (a)
(Canis familiaris)
Mammalia RAB40C 35
  • 91.21 (n)
  • 98.3 (a)
(Mus musculus)
Mammalia Rab40c 35
  • 90.51 (n)
  • 99.29 (a)
Rab40c 16
Rab40c 36
  • 99 (a)
(Pan troglodytes)
Mammalia RAB40C 35
  • 99.64 (n)
  • 100 (a)
RAB40C 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rab40c 35
  • 90.04 (n)
  • 99.29 (a)
(Monodelphis domestica)
Mammalia RAB40C 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia RAB40C 36
  • 97 (a)
(Gallus gallus)
Aves RAB40C 35
  • 88.26 (n)
  • 97.51 (a)
RAB40C 36
  • 98 (a)
(Anolis carolinensis)
Reptilia RAB40C 36
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab40c 35
  • 82.09 (n)
  • 95.37 (a)
(Danio rerio)
Actinopterygii rab40c 35
rab40c 35
  • 82.08 (n)
  • 94.27 (a)
rab40c 36
  • 96 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1900 37
  • 59 (a)
Rab40 35
  • 67.41 (n)
  • 69.2 (a)
Rab40 36
  • 61 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000841 35
  • 67.1 (n)
  • 65.24 (a)
Species with no ortholog for RAB40C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB40C Gene

Gene Tree for RAB40C (if available)
Gene Tree for RAB40C (if available)

Paralogs for RAB40C Gene

genes like me logo Genes that share paralogs with RAB40C: view

Variants for RAB40C Gene

Sequence variations from dbSNP and Humsavar for RAB40C Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs15564 -- 627,854(-) GTTTC(A/C)GACCA utr-variant-3-prime
rs4247097 -- 604,224(+) TCAGA(A/G)CTAGT intron-variant
rs8063979 -- 609,543(+) CCTTG(A/G)GGGTC intron-variant
rs12934493 -- 611,756(+) GTAGA(A/T)TCAAG intron-variant
rs12935215 -- 620,605(+) TCCAC(C/T)GCGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB40C Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2469n71 CNV Loss 21882294
nsv904707 CNV Loss 21882294
nsv528354 CNV Loss 19592680
nsv526903 CNV Loss 19592680
dgv2475n71 CNV Loss 21882294
dgv2476n71 CNV Loss 21882294
dgv2478n71 CNV Gain+Loss 21882294
dgv2479n71 CNV Loss 21882294
dgv2480n71 CNV Loss 21882294
nsv833113 CNV Loss 17160897
nsv833114 CNV Gain+Loss 17160897
dgv2481n71 CNV Loss 21882294
nsv471064 CNV Gain 18288195
nsv471063 CNV Loss 18288195
dgv2483n71 CNV Loss 21882294
dgv2484n71 CNV Loss 21882294
dgv2485n71 CNV Loss 21882294
nsv457304 CNV Gain 19166990
dgv2486n71 CNV Loss 21882294
esv1430130 CNV Insertion 17803354
nsv904759 CNV Loss 21882294
dgv334n27 CNV Loss 19166990
nsv904760 CNV Loss 21882294
dgv2487n71 CNV Loss 21882294
nsv516590 CNV Loss 19592680
dgv2488n71 CNV Loss 21882294
esv1254347 CNV Insertion 17803354
esv27398 CNV Loss 19812545
nsv821458 CNV Deletion 20802225
esv2446759 CNV Deletion 19546169
esv1293738 CNV Deletion 17803354
esv2750213 CNV Deletion 23290073
nsv904779 CNV Loss 21882294
nsv904781 CNV Gain 21882294

Variation tolerance for RAB40C Gene

Residual Variation Intolerance Score: 20.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.19% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RAB40C Gene

Disorders for RAB40C Gene

Relevant External Links for RAB40C

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RAB40C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB40C Gene

Publications for RAB40C Gene

  1. Rab GTPases and their roles in brain neurons and glia. (PMID: 18485483) Ng E.L. … Tang B.L. (Brain Res Rev 2008) 2 3 67
  2. Evolution of the Rab family of small GTP-binding proteins. (PMID: 11697911) Pereira-Leal J.B. … Seabra M.C. (J. Mol. Biol. 2001) 2 3
  3. Rab40C is a novel Varp-binding protein that promotes proteasomal degradation of Varp in melanocytes. (PMID: 25661869) Yatsu A. … Fukuda M. (Biol Open 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects. (PMID: 22993228) Williams F.M. … Spector T.D. (Ann. Rheum. Dis. 2013) 3

Products for RAB40C Gene

Sources for RAB40C Gene