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Aliases for RAB40B Gene

Aliases for RAB40B Gene

  • RAB40B, Member RAS Oncogene Family 2 3
  • SOCS Box-Containing Protein RAR 3 4
  • Protein Rar 3 4
  • SEC4L 3 4
  • GTP-Binding Protein Homologous To Saccharomyces Cerevisiae SEC4 3
  • RAR 3

External Ids for RAB40B Gene

Previous GeneCards Identifiers for RAB40B Gene

  • GC17M079683
  • GC17M083584
  • GC17M081144
  • GC17M081293
  • GC17M078208
  • GC17M080614
  • GC17M076014

Summaries for RAB40B Gene

Entrez Gene Summary for RAB40B Gene

  • The protein encoded by this gene has similarity to a yeast protein which suggests a role of the gene product in regulating secretory vesicles. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAB40B Gene

RAB40B (RAB40B, Member RAS Oncogene Family) is a Protein Coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB40A.

UniProtKB/Swiss-Prot for RAB40B Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB40B Gene

Genomics for RAB40B Gene

Regulatory Elements for RAB40B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAB40B Gene

Chromosome:
17
Start:
82,654,959 bp from pter
End:
82,698,728 bp from pter
Size:
43,770 bases
Orientation:
Minus strand

Genomic View for RAB40B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for RAB40B Gene

Proteins for RAB40B Gene

  • Protein details for RAB40B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12829-RB40B_HUMAN
    Recommended name:
    Ras-related protein Rab-40B
    Protein Accession:
    Q12829
    Secondary Accessions:
    • Q8WVG3

    Protein attributes for RAB40B Gene

    Size:
    278 amino acids
    Molecular mass:
    30956 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RAB40B Gene

Proteomics data for RAB40B Gene at MOPED

Post-translational modifications for RAB40B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB40B Gene

Antibody Products

No data available for DME Specific Peptides for RAB40B Gene

Domains & Families for RAB40B Gene

Gene Families for RAB40B Gene

Suggested Antigen Peptide Sequences for RAB40B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12829

UniProtKB/Swiss-Prot:

RB40B_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Belongs to the small GTPase superfamily. Rab family.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Contains 1 SOCS box domain.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB40B: view

Function for RAB40B Gene

Molecular function for RAB40B Gene

UniProtKB/Swiss-Prot Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for RAB40B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB40B: view

Phenotypes for RAB40B Gene

GenomeRNAi human phenotypes for RAB40B:
genes like me logo Genes that share phenotypes with RAB40B: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB40B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB40B Gene

Localization for RAB40B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB40B Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB40B Gene COMPARTMENTS Subcellular localization image for RAB40B gene
Compartment Confidence
endosome 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for RAB40B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005886 plasma membrane IEA --
GO:0010008 endosome membrane IBA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RAB40B: view

Pathways & Interactions for RAB40B Gene

SuperPathways for RAB40B Gene

No Data Available

UniProtKB/Swiss-Prot Q12829-RB40B_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RAB40B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0006904 NOT vesicle docking involved in exocytosis IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction --
genes like me logo Genes that share ontologies with RAB40B: view

No data available for Pathways by source and SIGNOR curated interactions for RAB40B Gene

Drugs & Compounds for RAB40B Gene

No Compound Related Data Available

Transcripts for RAB40B Gene

Unigene Clusters for RAB40B Gene

RAB40B, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB40B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB40B Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: - - -
SP2: - - - -
SP3: -
SP4: -
SP5:

Relevant External Links for RAB40B Gene

GeneLoc Exon Structure for
RAB40B
ECgene alternative splicing isoforms for
RAB40B

Expression for RAB40B Gene

mRNA expression in normal human tissues for RAB40B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB40B Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x4.5) and Brain - Nucleus accumbens (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for RAB40B Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAB40B Gene



SOURCE GeneReport for Unigene cluster for RAB40B Gene Hs.484068

genes like me logo Genes that share expression patterns with RAB40B: view

Protein tissue co-expression partners for RAB40B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RAB40B Gene

Orthologs for RAB40B Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB40B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAB40B 35
  • 88.37 (n)
  • 89.57 (a)
RAB40B 36
  • 88 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rab40b 35
  • 87.41 (n)
  • 92.81 (a)
Rab40b 16
Rab40b 36
  • 92 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RAB40B 35
  • 99.76 (n)
  • 100 (a)
RAB40B 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab40b 35
  • 86.81 (n)
  • 94.24 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 5 (a)
OneToMany
chicken
(Gallus gallus)
Aves RAB40B 35
  • 78.9 (n)
  • 90.29 (a)
RAB40B 36
  • 80 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 81 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rab40b 35
  • 80.58 (n)
  • 88.49 (a)
Str.14347 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.23887 35
zebrafish
(Danio rerio)
Actinopterygii rab40b 35
  • 74.22 (n)
  • 83.45 (a)
rab40b 36
  • 83 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.595 35
fruit fly
(Drosophila melanogaster)
Insecta CG1900 37
  • 60 (a)
Rab40 36
  • 59 (a)
OneToMany
Species with no ortholog for RAB40B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB40B Gene

ENSEMBL:
Gene Tree for RAB40B (if available)
TreeFam:
Gene Tree for RAB40B (if available)

Paralogs for RAB40B Gene

Paralogs for RAB40B Gene

genes like me logo Genes that share paralogs with RAB40B: view

Variants for RAB40B Gene

Sequence variations from dbSNP and Humsavar for RAB40B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs11105 -- 82,657,414(-) AAAGC(A/G)CCAAT utr-variant-3-prime, intron-variant
rs744991 -- 82,655,541(-) GCTCG(C/G)TGATG utr-variant-3-prime, nc-transcript-variant
rs756072 -- 82,664,225(+) AGATG(A/G)TGGTG intron-variant
rs878878 -- 82,666,173(+) CTGGA(C/T)TCAAG intron-variant
rs1057423 -- 82,655,675(-) TGCTG(A/T)GCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB40B Gene

Variant ID Type Subtype PubMed ID
nsv428351 CNV Gain 18775914
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
nsv909240 CNV Loss 21882294
dgv3363n71 CNV Loss 21882294
nsv909243 CNV Loss 21882294
nsv833575 CNV Loss 17160897
nsv509680 CNV Insertion 20534489
esv2716514 CNV Deletion 23290073
nsv820798 CNV Duplication 20802225
esv1683901 CNV Deletion 17803354
esv2716515 CNV Deletion 23290073
nsv909244 CNV Loss 21882294
esv1371613 CNV Deletion 17803354
esv1463213 CNV Deletion 17803354
esv1288593 CNV Deletion 17803354
esv2506580 CNV Insertion 19546169
esv1664800 CNV Insertion 17803354
esv1565279 CNV Insertion 17803354
esv2716516 CNV Deletion 23290073
esv1330810 CNV Insertion 17803354
esv2716517 CNV Deletion 23290073
esv2716519 CNV Deletion 23290073
esv2716520 CNV Deletion 23290073
esv5414 CNV Deletion 18987735
esv1007821 CNV Deletion 20482838
esv1706997 CNV Deletion 17803354
esv2716521 CNV Deletion 23290073

Variation tolerance for RAB40B Gene

Residual Variation Intolerance Score: 19.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.76; 78.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB40B Gene

HapMap Linkage Disequilibrium report
RAB40B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB40B Gene

Disorders for RAB40B Gene

Relevant External Links for RAB40B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB40B
genes like me logo Genes that share disorders with RAB40B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB40B Gene

Publications for RAB40B Gene

  1. Evolution of the Rab family of small GTP-binding proteins. (PMID: 11697911) Pereira-Leal J.B. … Seabra M.C. (J. Mol. Biol. 2001) 2 67
  2. A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor. (PMID: 1347744) Baniahmad A. … Renkawitz R. (EMBO J. 1992) 23 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia formation and invasion of breast cancer cells. (PMID: 23902685) Jacob A. … Prekeris R. (J. Cell. Sci. 2013) 67
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 67

Products for RAB40B Gene

Sources for RAB40B Gene

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