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Aliases for RAB40B Gene

Aliases for RAB40B Gene

  • RAB40B, Member RAS Oncogene Family 2 3
  • SOCS Box-Containing Protein RAR 3 4
  • Protein Rar 3 4
  • SEC4L 3 4
  • GTP-Binding Protein Homologous To Saccharomyces Cerevisiae SEC4 3
  • Ras-Related Protein Rab-40B 3
  • RAR 3

External Ids for RAB40B Gene

Summaries for RAB40B Gene

Entrez Gene Summary for RAB40B Gene

  • The protein encoded by this gene has similarity to a yeast protein which suggests a role of the gene product in regulating secretory vesicles. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAB40B Gene

RAB40B (RAB40B, Member RAS Oncogene Family) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB40A.

UniProtKB/Swiss-Prot for RAB40B Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB40B Gene

Genomics for RAB40B Gene

Genomic Location for RAB40B Gene

Start:
82,654,973 bp from pter
End:
82,698,728 bp from pter
Size:
43,756 bases
Orientation:
Minus strand

Genomic View for RAB40B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB40B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB40B Gene

Regulatory Elements for RAB40B Gene

Proteins for RAB40B Gene

  • Protein details for RAB40B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12829-RB40B_HUMAN
    Recommended name:
    Ras-related protein Rab-40B
    Protein Accession:
    Q12829
    Secondary Accessions:
    • Q8WVG3

    Protein attributes for RAB40B Gene

    Size:
    278 amino acids
    Molecular mass:
    30956 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RAB40B Gene

Proteomics data for RAB40B Gene at MOPED

Post-translational modifications for RAB40B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB40B Gene

No data available for DME Specific Peptides for RAB40B Gene

Domains for RAB40B Gene

Gene Families for RAB40B Gene

HGNC:
  • RAB :RAB, member RAS oncogene

UniProtKB/Swiss-Prot:

RB40B_HUMAN
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.:
    • Q12829
  • Contains 1 SOCS box domain.:
    • Q12829
Family:
  • Belongs to the small GTPase superfamily. Rab family.:
    • Q12829
genes like me logo Genes that share domains with RAB40B: view

Function for RAB40B Gene

Molecular function for RAB40B Gene

UniProtKB/Swiss-Prot Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for RAB40B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB40B: view

Phenotypes for RAB40B Gene

GenomeRNAi human phenotypes for RAB40B:
genes like me logo Genes that share phenotypes with RAB40B: view

miRNA for RAB40B Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB40B Gene

Localization for RAB40B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB40B Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB40B Gene COMPARTMENTS Subcellular localization image for RAB40B gene
Compartment Confidence
plasma membrane 5
cytosol 3
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RAB40B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005886 plasma membrane IEA --
GO:0010008 endosome membrane IBA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RAB40B: view

Pathways for RAB40B Gene

SuperPathways for RAB40B Gene

No Data Available

UniProtKB/Swiss-Prot Q12829-RB40B_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RAB40B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006904 NOT vesicle docking involved in exocytosis IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RAB40B: view

No data available for Pathways by source for RAB40B Gene

Transcripts for RAB40B Gene

Unigene Clusters for RAB40B Gene

RAB40B, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB40B Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: - - -
SP2: - - - -
SP3: -
SP4: -
SP5:

Relevant External Links for RAB40B Gene

GeneLoc Exon Structure for
RAB40B
ECgene alternative splicing isoforms for
RAB40B

Expression for RAB40B Gene

mRNA expression in normal human tissues for RAB40B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB40B Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (4.5) and Brain - Nucleus accumbens (basal ganglia) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RAB40B Gene

SOURCE GeneReport for Unigene cluster for RAB40B Gene Hs.484068

genes like me logo Genes that share expressions with RAB40B: view

Orthologs for RAB40B Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB40B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB40B 36
  • 99.76 (n)
  • 100 (a)
RAB40B 37
  • 71 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB40B 36
  • 88.37 (n)
  • 89.57 (a)
RAB40B 37
  • 88 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 62 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rab40b 36
  • 87.41 (n)
  • 92.81 (a)
Rab40b 16
Rab40b 37
  • 92 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 5 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rab40b 36
  • 86.81 (n)
  • 94.24 (a)
chicken
(Gallus gallus)
Aves RAB40B 36
  • 78.9 (n)
  • 90.29 (a)
RAB40B 37
  • 80 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 81 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.23887 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rab40b 36
  • 80.58 (n)
  • 88.49 (a)
Str.14347 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.595 36
zebrafish
(Danio rerio)
Actinopterygii rab40b 36
  • 74.22 (n)
  • 83.45 (a)
rab40b 37
  • 83 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Rab40 37
  • 59 (a)
OneToMany
CG1900 38
  • 60 (a)
Species with no ortholog for RAB40B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB40B Gene

ENSEMBL:
Gene Tree for RAB40B (if available)
TreeFam:
Gene Tree for RAB40B (if available)

Paralogs for RAB40B Gene

Paralogs for RAB40B Gene

genes like me logo Genes that share paralogs with RAB40B: view

Variants for RAB40B Gene

Sequence variations from dbSNP and Humsavar for RAB40B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs11105 -- 82,657,414(-) AAAGC(A/G)CCAAT utr-variant-3-prime
rs756072 -- 82,664,225(+) AGATG(A/G)TGGTG intron-variant
rs878878 -- 82,666,173(+) CTGGA(C/T)TCAAG intron-variant
rs1210094 -- 82,666,264(-) tccat(C/T)tcaaa intron-variant
rs2015031 -- 82,664,288(+) TCCCC(A/G)GGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB40B Gene

Variant ID Type Subtype PubMed ID
nsv428351 CNV Gain 18775914
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
nsv909240 CNV Loss 21882294
dgv3363n71 CNV Loss 21882294
nsv909243 CNV Loss 21882294
nsv833575 CNV Loss 17160897
nsv509680 CNV Insertion 20534489
esv2716514 CNV Deletion 23290073
nsv820798 CNV Duplication 20802225
esv1683901 CNV Deletion 17803354
esv2716515 CNV Deletion 23290073
nsv909244 CNV Loss 21882294
esv1371613 CNV Deletion 17803354
esv1463213 CNV Deletion 17803354
esv1288593 CNV Deletion 17803354
esv2506580 CNV Insertion 19546169
esv1664800 CNV Insertion 17803354
esv1565279 CNV Insertion 17803354
esv2716516 CNV Deletion 23290073
esv1330810 CNV Insertion 17803354
esv2716517 CNV Deletion 23290073
esv2716519 CNV Deletion 23290073
esv2716520 CNV Deletion 23290073
esv5414 CNV Deletion 18987735
esv1007821 CNV Deletion 20482838
esv1706997 CNV Deletion 17803354
esv2716521 CNV Deletion 23290073

Relevant External Links for RAB40B Gene

HapMap Linkage Disequilibrium report
RAB40B

Disorders for RAB40B Gene

No disorders were found for RAB40B Gene.

No data available for UniProtKB/Swiss-Prot for RAB40B Gene

Publications for RAB40B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Evolution of the Rab family of small GTP-binding proteins. (PMID: 11697911) Pereira-Leal J.B. … Seabra M.C. (J. Mol. Biol. 2001) 2 3
  3. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for RAB40B Gene

Sources for RAB40B Gene

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