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Aliases &
Descriptions
for RAB40AL
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| MGC119958 2 | | MGC119959 2 | | MGC119960 2 | | MGC119961 2 | | RAR2 1, 2 | | RLGP 1, 2, 3 |
| | | Descriptions |
|---|
| RAB40A, member RAS oncogene family-like 2 | | Ras like GTPase 2 | | Ras-like GTPase 2, 3 | | Ras-like GTPase-like 2 | | SOCS box containing protein RAR2 2 |
|
| |
Search outside databases for aliases for RAB40AL genePrevious GC identifer: GC00U921648 |
Summaries
for RAB40AL(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: RB40L_HUMAN, P0C0E4Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box
protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal
degradation of target proteins (By similarity) |
Genomic Location
for RAB40AL
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq22.2 Ensembl cytogenetic band: Xq22.1 HGNC cytogenetic band: Xq22.2RAB40AL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP102079:
(about GC identifiers)
Start:
|
102,078,856 bp from pter |
End:
|
102,079,884 bp from pter |
Size:
|
1,029 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000023.9 NT_011651.16
| Proteins
for RAB40AL
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RB40L_HUMAN, P0C0E4 (See
protein sequence)Recommended Name: Ras-related protein Rab-40A-like Size: 278 amino acids; 31239 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Mitochondrion
Secondary accessions: Q495H3REFSEQ proteins: NP_001027004.1
ENSEMBL proteins: ENSP00000218249
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- | | GO:0005886 | plasma membrane |
IEA | -- |
About this table
Antibodies for RAB40AL:
Assays for RAB40AL: | Protein
Domains/
Families
for RAB40AL(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P0C0E4
ProtoNet protein and cluster: P0C0E4 1 Blocks protein family: IPB001496 SOCS protein
UniProtKB/Swiss-Prot: RB40L_HUMAN, P0C0E4Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module
in different E3 ubiquitin ligase complexes (By similarity)Similarity: Belongs to the small GTPase superfamily. Rab familySimilarity: Contains 1 SOCS box domain | Gene Function
for RAB40AL
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| Browse Origene for 29mer shRNA kit in GFP-retroviral vector
 Applied Biosystems Silencer® siRNAs for RAB40AL
 Sigma-Aldrich siRNA for RAB40AL
Browse shRNA at Sigma-Aldrich
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_001031834
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001031834
untagged cDNA clone in CMV expression vector: NM_001031834
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_001031834
UniProtKB/Swiss-Prot: RB40L_HUMAN, P0C0E4Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box
protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal
degradation of target proteins (By similarity)2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0005525 | GTP binding |
IEA | -- |
About this table | Pathways & Interactions
for RAB40AL
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: RB40L_HUMAN, P0C0E4Pathway: Protein modification; protein ubiquitination3 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- | | GO:0019941 | modification-dependent protein catabolic process |
IEA | -- |
About this table
|
Drugs & Compounds
for RAB40AL(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for RAB40AL
|
Transcripts
for RAB40AL(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| Browse Origene for 29mer shRNA kit in GFP-retroviral vector
Sigma-Aldrich siRNA for RAB40AL
Browse shRNA at Sigma-Aldrich
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_001031834 REFSEQ mRNAs for RAB40AL gene: NM_001031834.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001031834
OriGene GFP tagged cDNA clone in CMV expression vector: NM_001031834
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001031834
untagged cDNA clone in CMV expression vector: NM_001031834
Additional cDNA sequence: BC101169.1 BC101170.2 BC101171.1 BC101172.1 1 DOTS entry: DT.121305595 Unigene Cluster for RAB40AL: RAB40A, member RAS oncogene family-like Hs.449517 Unigene Representative Sequence: BC101170
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000218249
|
Expression
for RAB40AL
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RAB40AL expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RAB40AL
1 / 2 4 probe-sets matching RAB40AL gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GGAACAATGC
SOURCE GeneReport for Unigene cluster: Hs.449517
UniProtKB/Swiss-Prot: RB40L_HUMAN, P0C0E4Tissue specificity: Expressed in brain, heart, skeletal muscle, kidney and liver. Highest
expression in brain |
Orthologs
for RAB40AL
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB40AL gene from 1 species
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
chimpanzee
(Pan troglodytes) |
RAB40AL1 |
-- |
RAB40A, member RAS oncogene family-like |
99.28(n)
99.28(a) |
736284 XM_001136104.1 XP_001136104.1 |
About this table Species with no ortholog for RAB40AL
ENSEMBL Gene Tree for RAB40AL | Paralogs
for RAB40AL(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for RAB40AL gene
- RAB40A2 RAB40C2 RAB40B2
|
SNPs/Variants
for RAB40AL(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RAB40AL (up to first 250kb)
|
Disorders & Mutations
for RAB40AL
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 300405
|
Medical News
for RAB40AL(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for RAB40AL (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 5 PubMed articles for RAB40AL gene: |
Search for RAB40AL
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RAB40AL
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RAB40AL
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB40AL(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for RAB40AL(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for RAB40AL:
 | |
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