RAB40A Gene
protein-coding GIFtS: 45
GCID: GC0XM102754
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RAB40A, member RAS oncogene family
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Aliases
for RAB40A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RAB40A, Member RAS Oncogene Family1 2 | | Rar-21 | | RAR2A1 2 | | RAR22 | | Protein Rar-22 3 | | Ras-Related Protein Rab-40A2 | | SOCS Box-Containing Protein RAR2A2 3 | | SOCS Box Containing Protein RAR2A2 |
Export aliases for RAB40A gene to outside databasesPrevious GC identifers: GC0XM098056 GC0XM099663 GC0XM100787 GC0XM101526 GC0XM102560 GC0XM102641 GC0XM092410 |
Summaries
for RAB40A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RAB40A:
This gene encodes a member of the Rab40 subfamily of Rab small GTP-binding proteins that contains a C-terminalsuppressors of cytokine signaling box. (provided by RefSeq, Apr 2010)
UniProtKB/Swiss-Prot: RB40A_HUMAN, Q8WXH6Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitinligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (Bysimilarity)
Gene Wiki entry for RAB40A
|
Genomic Views
for RAB40A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAB40A gene promoter:
AP-2rep LHX3b/Lhx3b HNF-1A POU2F1 POU2F1b POU2F1a HNF-1 LHX3a/Lhx3a Cart-1 POU2F1c
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAB40A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB40A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq22.1 Ensembl cytogenetic band: Xq22.2 HGNC cytogenetic band: Xq22.1RAB40A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM102754: view genomic region
(about GC identifiers)
Start:
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102,754,678 bp from pter |
End:
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102,774,417 bp from pter |
Size:
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19,740 bases |
Orientation:
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minus strand |
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Proteins
for RAB40A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RB40A_HUMAN, Q8WXH6 (See
protein sequence)Recommended Name: Ras-related protein Rab-40A precursor Size: 277 amino acids; 31076 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions: O00407 Q17RQ5 Q6DK06 Q8TF06Explore the universe of human proteins at neXtProt for RAB40A: NX_Q8WXH6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WXH6
RAB40A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_543155.2
ENSEMBL proteins: ENSP00000361716 ENSP00000305648
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
RAB40A for ontologies About GeneDecksing
RAB40A Antibody Products:
Assay Products for RAB40A: |
Protein
Domains /
Families
for RAB40A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAB40A for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WXH6ProtoNet protein and cluster: Q8WXH6 2 Blocks protein families: IPB001496 SOCS protein IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: RB40A_HUMAN, Q8WXH6Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3ubiquitin ligase complexes (By similarity)Similarity: Belongs to the small GTPase superfamily. Rab familySimilarity: Contains 1 SOCS box domain |
Function
for RAB40A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RB40A_HUMAN, Q8WXH6Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitinligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (Bysimilarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB40A
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB40A |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005525 | GTP binding |
IEA | -- |
RAB40A for ontologies About GeneDecksing
|
Pathways & Interactions
for RAB40A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: RB40A_HUMAN, Q8WXH6Pathway: Protein modification; protein ubiquitinationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAB40A
1 Interacting protein for RAB40A (Q8WXH62) via UniProtKB, MINT, STRING, and/or I2D About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- | | GO:0016567 | protein ubiquitination |
IEA | -- |
RAB40A for ontologies About GeneDecksing
|
Drugs & Compounds
for RAB40A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RAB40A
Search CenterWatch for drugs/clinical trials and news about RAB40A / RB40A
|
Transcripts
for RAB40A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RAB40A gene: NM_080879.2 Unigene Cluster for RAB40A: RAB40A, member RAS oncogene family Hs.706904 [show with all ESTs]Unigene Representative Sequence: BC0456742 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372633(uc022cbs.1) ENST00000304236(uc004ekk.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB40A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB40A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RAB40A (NM_080879) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAB40A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB40A |
Additional cDNA sequence: AB232637.1 AF132748.1 AF422143.1 BC045674.1 BC074854.2 BC074855.2 BC113501.1 BC117232.1 3 DOTS entries: DT.97836075 DT.441188 DT.100700779 15 AceView cDNA sequences: BC074854 AF132748 Z43570 BC074855 AK056859 AF422143 NM_080879 H24205 BC045674 AW300309 Z39635 H24206 CF264884 BI562054 R48513
GeneLoc Exon Structure
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Expression
for RAB40A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RAB40A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RAB40A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAB40A
SOURCE GeneReport for Unigene cluster: Hs.706904
SABiosciences Custom PCR Arrays for RAB40A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB40A
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB40A |
Orthologs
for RAB40A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RAB40A gene from 4/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
F1NPF9_CHICK6 |
Uncharacterized protein |
74(a) |
1 → many |
18(3338797-3361778) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
74(a) |
1 → many |
2(103680964-103703579) |
zebrafish
(Danio rerio) |
Actinopterygii |
rab40b6 |
RAB40B, member RAS oncogene family |
77(a) |
1 → many |
12(33726278-33753571) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG19003 |
RAB small monomeric GTPase |
58(a) |
|
11A11 -- |
Species with no ortholog for RAB40A
ENSEMBL Gene Tree for RAB40A (if available)
TreeFam Gene Tree for RAB40A (if available) |
Paralogs
for RAB40A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RAB40A gene
- RAB40C2 RAB40AL2 RAB40B2
18/56 SIMAP similar genes for RAB40A using alignment to 1 protein entry: RB40A_HUMAN(see all similar genes):RAB40AL RAB40B RAB40C RAB10 RAB13 DKFZp686J07132
RAB8A RAB8B RAB15 RAB19 RAB43 RAB11A
RAB11B RAB30 RAB1B RAB35 RAB37 RAB3C
RAB40A for paralogs About GeneDecksing
|
Genomic Variants
for RAB40A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RAB40A (102754678 - 102774417 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RAB40A: --
Locus Specific Mutation Databases (LSDB): RAB40A
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB40A |
|
Disorders
/ Diseases
for RAB40A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for RAB40A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RAB40A gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with RAB40A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. (PubMed id 16923123)1, 2 Itoh T.... Fukuda M. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Evolution of the Rab family of small GTP-binding proteins. (PubMed id 11697911)1, 3 Pereira-Leal J.B. and Seabra M.C. (2001)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. (PubMed id 12578829)1 Fukuda M. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. (PubMed id 11773082)1 Kuroda T.S.... Mikoshiba K. (2002)
- The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1 Kile B.T....Hilton D.J. (2002)
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External Searches for RAB40A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RAB40A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RAB40A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB40A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RAB40A gene:
Search GeneIP for patents involving RAB40A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RAB40A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |  |  |  |  | | | | |
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 | | | RAB40A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB40A |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB40A |
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