RAB40A Gene

Aliases
for RAB40A gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC0XM098056 GC0XM099663 GC0XM100787 GC0XM101526 GC0XM102560 GC0XM102641 GC0XM092410

Summaries
for RAB40A gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for RAB40A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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SwitchGear Promoter luciferase reporter plasmid: RAB40A promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAB40A

RAB40A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM102754:  view genomic region     (about GC identifiers)

Proteins
for RAB40A gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for RAB40A: NX_Q8WXH6

Explore proteomics data for RAB40A at MOPED

Post-translational modifications: 

RAB40A Human Recombinant Protein Products:

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Domains /
Families
for RAB40A gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q8WXH6

Find genes that share domains with RAB40A           About GenesLikeMe

Function
for RAB40A gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for RAB40A

miRNA Products:		miRTarBase miRNAs that target RAB40A: hsa-mir-335-5p (MIRT017532)
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Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for RAB40A

Clone Products:		OriGene clones in human, mouse for RAB40A (see all 6) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		Sino Biological Human cDNA Clone for RAB40A
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB40A

Localization
for RAB40A gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	5
cytosol	3
extracellular	1
peroxisome	1

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Gene Ontology (GO): 3 cellular component terms:    About this table

Pathways & Interactions
for RAB40A gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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    Custom Pathway & Disease-focused RT² Profiler PCR Arrays for RAB40A
Interactions:

    Search GeneGlobe Interaction Network for RAB40A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for RAB40A (Q8WXH6² ENSP00000305648⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 26)

Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

Drugs & Compounds
for RAB40A gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for RAB40A gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for RAB40A gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RAB40A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Primer Products:		OriGene qPCR primer pairs and template standards for RAB40A OriGene qSTAR qPCR primer pairs in human, mouse for RAB40A
		Pre-validated RT2 qPCR Primer Assay in human, mouse / rat RAB40A
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		QuantiFast Probe-based Assays in human, mouse, rat RAB40A

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB40A

Orthologs
for RAB40A gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for RAB40A gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for RAB40A gene

RAB40C²  RAB40AL²  RAB40B²  

Selected SIMAP similar genes for RAB40A using alignment to 1 protein entry:     RB40A_HUMAN(see all similar genes):

RAB40AL    RAB40B    RAB40C    RAB10    RAB13    DKFZp686J07132

RAB8A    RAB8B    RAB15    RAB11B    RAB19    RAB43

RAB11A    RAB30    RAB1B    RAB35    RAB37    RAB3C

Find genes that share paralogs with RAB40A           About GenesLikeMe

Genomic Variants
for RAB40A gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RAB40A (see all 272)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs59032161,2	C	--	92424574(+)	GAAAGG/-AAAAT	1	--	int1		1		CSA	2
rs556707391,2	C	--	102723736(+)	CTGTTA/GTATAC	1	--	ds5001		0	--	--	--	--
rs1911289161,2		--	102723876(+)	GAATTC/TATACT	1	--	ds5001		0	--	--	--	--
rs1405111131,2	C,F	--	102724306(+)	GATCTC/TCACTT	2	K E	mis1		1		NA	4532
rs1996697441,2	C	--	102724341(+)	AGCTGC/GTGGTG	2	T S	mis1		0	--	--	--	--
rs1823684691,2	C	--	102724366(+)	GCCTCA/GCATCA	2	R *	stg1		0	--	--	--	--
rs617355251,2	C,F	--	102724403(+)	GAGAAG/AGACTT	2	/S	syn1		2		NS NA	4624
rs617355241,2	C,F	--	102724404(+)	AGAAGG/AACTTG	2	/S /F	mis1		3		NS WA NA	4630
rs1393895791,2	C	--	102724417(+)	GTGGCC/TTCTTA	2	S G	mis1		0	--	--	--	--
rs2014665011,2	C	--	102724426(+)	TAAGGC/TACTGG	2	T A	mis1		0	--	--	--	--

HapMap Linkage Disequilibrium report for RAB40A (102754678 - 102774417 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for RAB40A: --
Locus Specific Mutation Databases (LSDB): RAB40A

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing RAB40A

DNA2.0 Custom Variant and Variant Library Synthesis for RAB40A

Disorders / Diseases
for RAB40A gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for RAB40A gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. (PubMed id 16923123)^{1, 2} Itoh T.... Fukuda M. (Genes Cells 2006)
2. The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (Nature 2005)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
4. Evolution of the Rab family of small GTP-binding proteins. (PubMed id 11697911)^{1, 3} Pereira-Leal J.B. and Seabra M.C. (J. Mol. Biol. 2001)
5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)¹ Taipale M....Lindquist S. (Cell 2012)
6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (amp 2011)
7. Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis. (PubMed id 20360680)¹ Schlager M.A....Hoogenraad C.C. (EMBO J. 2010)
8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (Nat. Genet. 2004)
9. Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. (PubMed id 12578829)¹ Fukuda M. (J. Biol. Chem. 2003)
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

External Searches for RAB40A gene

Genome Databases showing RAB40A gene

Other Databases showing RAB40A gene

Specialized Databases showing RAB40A gene

Products
for RAB40A gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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