Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RAB40A Gene

Aliases for RAB40A Gene

  • RAB40A, Member RAS Oncogene Family 2 3 5
  • SOCS Box-Containing Protein RAR2A 3 4
  • Protein Rar-2 3 4
  • Ras-Related Protein Rab-40A 3
  • RAR2A 3
  • RAR2 3

External Ids for RAB40A Gene

Previous GeneCards Identifiers for RAB40A Gene

  • GC0XM098056
  • GC0XM099663
  • GC0XM100787
  • GC0XM101526
  • GC0XM102560
  • GC0XM102641
  • GC0XM102754
  • GC0XM092410

Summaries for RAB40A Gene

Entrez Gene Summary for RAB40A Gene

  • This gene encodes a member of the Rab40 subfamily of Rab small GTP-binding proteins that contains a C-terminal suppressors of cytokine signaling box. [provided by RefSeq, Apr 2010]

GeneCards Summary for RAB40A Gene

RAB40A (RAB40A, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Metabolism of proteins. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB40AL.

UniProtKB/Swiss-Prot for RAB40A Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Wiki entry for RAB40A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB40A Gene

Genomics for RAB40A Gene

Regulatory Elements for RAB40A Gene

Enhancers for RAB40A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF104155 0.6 ENCODE 18.8 -637.3 -637349 2.5 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 MORF4L2-AS1 ENSG00000235946 RAB40A TCEAL9 SLC25A53 LOC286437
GH0XF103684 0.4 ENCODE 15.3 -167.5 -167533 4.4 PKNOX1 ARNT CREB3L1 ARID4B SIN3A ZNF2 YY1 ZNF207 ZNF143 FOS MORF4L2-AS1 LINC00630 ENSG00000239407 RAB40A TCEAL9 LOC100128601 BEX4 LOC100130176
GH0XF103464 1 Ensembl ENCODE 10.5 +54.8 54845 1.1 CTCF PKNOX1 ZNF654 RAD21 ZNF264 FOXK2 GLIS1 SMC3 PRDM10 ZSCAN29 TCEAL9 BEX3 MORF4L2-AS1 RAB40A LOC100128601 PIR62779 PIR37216
GH0XF103253 0.2 ENCODE 10.3 +264.8 264780 2.8 PKNOX1 ATF1 CREB3L1 FEZF1 ZNF48 ETS1 SP3 SP5 TSHZ1 MBD2 RAB40A BEX1 TCEAL8 GC0XM103234
GH0XF104165 0.7 ENCODE 10.2 -647.2 -647160 2.8 ATF1 ZFP64 SIN3A ZNF2 ZNF121 GLIS2 ELK1 ZNF143 KLF7 KLF13 SLC25A53 RAB40A FAM199X GC0XM104199
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RAB40A on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB40A Gene

Chromosome:
X
Start:
103,499,130 bp from pter
End:
103,519,489 bp from pter
Size:
20,360 bases
Orientation:
Minus strand

Genomic View for RAB40A Gene

Genes around RAB40A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB40A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB40A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB40A Gene

Proteins for RAB40A Gene

  • Protein details for RAB40A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXH6-RB40A_HUMAN
    Recommended name:
    Ras-related protein Rab-40A
    Protein Accession:
    Q8WXH6
    Secondary Accessions:
    • O00407
    • Q17RQ5
    • Q6DK06
    • Q8TF06

    Protein attributes for RAB40A Gene

    Size:
    277 amino acids
    Molecular mass:
    31076 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RAB40A Gene

Post-translational modifications for RAB40A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB40A Gene

No data available for DME Specific Peptides for RAB40A Gene

Domains & Families for RAB40A Gene

Gene Families for RAB40A Gene

Suggested Antigen Peptide Sequences for RAB40A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXH6

UniProtKB/Swiss-Prot:

RB40A_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Belongs to the small GTPase superfamily. Rab family.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Contains 1 SOCS box domain.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB40A: view

Function for RAB40A Gene

Molecular function for RAB40A Gene

UniProtKB/Swiss-Prot Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for RAB40A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB40A: view

Phenotypes for RAB40A Gene

genes like me logo Genes that share phenotypes with RAB40A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB40A Gene

Localization for RAB40A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB40A Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB40A Gene COMPARTMENTS Subcellular localization image for RAB40A gene
Compartment Confidence
plasma membrane 4
cytosol 3
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RAB40A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RAB40A: view

Pathways & Interactions for RAB40A Gene

genes like me logo Genes that share pathways with RAB40A: view

Pathways by source for RAB40A Gene

UniProtKB/Swiss-Prot Q8WXH6-RB40A_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RAB40A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with RAB40A: view

No data available for SIGNOR curated interactions for RAB40A Gene

Transcripts for RAB40A Gene

mRNA/cDNA for RAB40A Gene

(3) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB40A Gene

RAB40A, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB40A Gene

No ASD Table

Relevant External Links for RAB40A Gene

GeneLoc Exon Structure for
RAB40A
ECgene alternative splicing isoforms for
RAB40A

Expression for RAB40A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAB40A Gene

NURSA nuclear receptor signaling pathways regulating expression of RAB40A Gene:

RAB40A

SOURCE GeneReport for Unigene cluster for RAB40A Gene:

Hs.706904
genes like me logo Genes that share expression patterns with RAB40A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RAB40A Gene

Orthologs for RAB40A Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB40A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB40A 34 35
  • 99.04 (n)
mouse
(Mus musculus)
Mammalia Rab40b 35
  • 82 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RAB40B 35
  • 79 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 56 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 4 (a)
OneToMany
chicken
(Gallus gallus)
Aves RAB40B 35
  • 72 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 73 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii rab40b 35
  • 77 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1900 36
  • 58 (a)
Rab40 35
  • 57 (a)
OneToMany
Species where no ortholog for RAB40A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB40A Gene

ENSEMBL:
Gene Tree for RAB40A (if available)
TreeFam:
Gene Tree for RAB40A (if available)

Paralogs for RAB40A Gene

Variants for RAB40A Gene

Sequence variations from dbSNP and Humsavar for RAB40A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs10127233 -- 103,512,375(+) CACAT(C/G)CTGGT intron-variant
rs10521501 -- 103,503,304(+) GTGTC(C/T)ATAGG intron-variant, utr-variant-5-prime
rs111385536 -- 103,513,110(+) GGCAA(A/G)CACGT intron-variant
rs111711166 -- 103,505,500(+) CTTTT(C/T)TTTAG intron-variant, upstream-variant-2KB
rs111760830 -- 103,513,492(+) GAAAG(A/G)AAATA intron-variant

Variation tolerance for RAB40A Gene

Residual Variation Intolerance Score: 90.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.53; 77.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB40A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB40A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RAB40A Gene

Disorders for RAB40A Gene

Relevant External Links for RAB40A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB40A

No disorders were found for RAB40A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB40A Gene

Publications for RAB40A Gene

  1. Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. (PMID: 16923123) Itoh T. … Fukuda M. (Genes Cells 2006) 3 4 64
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Evolution of the Rab family of small GTP-binding proteins. (PMID: 11697911) Pereira-Leal J.B. … Seabra M.C. (J. Mol. Biol. 2001) 2 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for RAB40A Gene

Sources for RAB40A Gene

Content
Loading form....