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Aliases for RAB40A Gene

Aliases for RAB40A Gene

  • RAB40A, Member RAS Oncogene Family 2 3
  • SOCS Box-Containing Protein RAR2A 3 4
  • Protein Rar-2 3 4
  • SOCS Box Containing Protein RAR2A 3
  • Ras-Related Protein Rab-40A 3
  • RAB40AL 6
  • MRXSMP 6
  • RAR2A 3
  • RAR2 3
  • RLGP 6

External Ids for RAB40A Gene

Summaries for RAB40A Gene

Entrez Gene Summary for RAB40A Gene

  • This gene encodes a member of the Rab40 subfamily of Rab small GTP-binding proteins that contains a C-terminal suppressors of cytokine signaling box. [provided by RefSeq, Apr 2010]

GeneCards Summary for RAB40A Gene

RAB40A (RAB40A, Member RAS Oncogene Family) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB40B.

UniProtKB/Swiss-Prot for RAB40A Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Wiki entry for RAB40A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB40A Gene

Genomics for RAB40A Gene

Genomic Location for RAB40A Gene

Start:
103,498,118 bp from pter
End:
103,519,489 bp from pter
Size:
21,372 bases
Orientation:
Minus strand

Genomic View for RAB40A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB40A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB40A Gene

Regulatory Elements for RAB40A Gene

Proteins for RAB40A Gene

  • Protein details for RAB40A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXH6-RB40A_HUMAN
    Recommended name:
    Ras-related protein Rab-40A
    Protein Accession:
    Q8WXH6
    Secondary Accessions:
    • O00407
    • Q17RQ5
    • Q6DK06
    • Q8TF06

    Protein attributes for RAB40A Gene

    Size:
    277 amino acids
    Molecular mass:
    31076 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RAB40A Gene

Proteomics data for RAB40A Gene at MOPED

Post-translational modifications for RAB40A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB40A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB40A Gene

Domains for RAB40A Gene

Gene Families for RAB40A Gene

HGNC:
  • RAB :RAB, member RAS oncogene

UniProtKB/Swiss-Prot:

RB40A_HUMAN
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.:
    • Q8WXH6
  • Contains 1 SOCS box domain.:
    • Q8WXH6
Family:
  • Belongs to the small GTPase superfamily. Rab family.:
    • Q8WXH6
genes like me logo Genes that share domains with RAB40A: view

Function for RAB40A Gene

Molecular function for RAB40A Gene

UniProtKB/Swiss-Prot Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for RAB40A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB40A: view

miRNA for RAB40A Gene

miRTarBase miRNAs that target RAB40A

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB40A Gene

Localization for RAB40A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB40A Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB40A Gene COMPARTMENTS Subcellular localization image for RAB40A gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RAB40A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005886 plasma membrane IEA --
GO:0010008 endosome membrane IBA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RAB40A: view

Pathways for RAB40A Gene

SuperPathways for RAB40A Gene

No Data Available

UniProtKB/Swiss-Prot Q8WXH6-RB40A_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Interacting Proteins for RAB40A Gene

Gene Ontology (GO) - Biological Process for RAB40A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006904 NOT vesicle docking involved in exocytosis IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RAB40A: view

No data available for Pathways by source for RAB40A Gene

Transcripts for RAB40A Gene

mRNA/cDNA for RAB40A Gene

(7) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB40A Gene

RAB40A, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB40A Gene

No ASD Table

Relevant External Links for RAB40A Gene

GeneLoc Exon Structure for
RAB40A
ECgene alternative splicing isoforms for
RAB40A

Expression for RAB40A Gene

mRNA expression in normal human tissues for RAB40A Gene

SOURCE GeneReport for Unigene cluster for RAB40A Gene Hs.706904

genes like me logo Genes that share expressions with RAB40A: view

Orthologs for RAB40A Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB40A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB40A 36
  • 99.04 (n)
  • 99.28 (a)
RAB40A 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB40B 37
  • 79 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 56 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rab40b 37
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 4 (a)
OneToMany
chicken
(Gallus gallus)
Aves RAB40B 37
  • 72 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 73 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii rab40b 37
  • 77 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Rab40 37
  • 57 (a)
OneToMany
CG1900 38
  • 58 (a)
Species with no ortholog for RAB40A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB40A Gene

ENSEMBL:
Gene Tree for RAB40A (if available)
TreeFam:
Gene Tree for RAB40A (if available)

Paralogs for RAB40A Gene

Paralogs for RAB40A Gene

genes like me logo Genes that share paralogs with RAB40A: view

Variants for RAB40A Gene

Sequence variations from dbSNP and Humsavar for RAB40A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1180888 -- 103,515,473(+) TTTGA(C/G)GAAGG intron-variant
rs1180895 - 103,500,623(+) CGAGA(A/T)GGCTG reference, missense
rs1180896 -- 103,506,318(+) agtgt(C/T)catta intron-variant
rs2858077 -- 103,512,981(-) ATCAT(A/T)CCTAA intron-variant
rs2858078 -- 103,512,980(-) TCATT(C/T)CTAAC intron-variant

Relevant External Links for RAB40A Gene

HapMap Linkage Disequilibrium report
RAB40A
Locus Specific Mutation Databases (LSDB)
RAB40A

No data available for Structural Variations from Database of Genomic Variants (DGV) for RAB40A Gene

Disorders for RAB40A Gene

(1) OMIM Diseases for RAB40A Gene (300405)

No disorders were found for RAB40A Gene.

No data available for UniProtKB/Swiss-Prot for RAB40A Gene

Publications for RAB40A Gene

  1. Evolution of the Rab family of small GTP-binding proteins. (PMID: 11697911) Pereira-Leal J.B. … Seabra M.C. (J. Mol. Biol. 2001) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. (PMID: 16923123) Itoh T. … Fukuda M. (Genes Cells 2006) 3 4
  5. Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis. (PMID: 20360680) Schlager M.A. … Hoogenraad C.C. (EMBO J. 2010) 3

Products for RAB40A Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate RAB40A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RAB40A
    • Block miRNA regulation of RAB40A using miScript Target Protectors

    Sources for RAB40A Gene

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