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Aliases & Descriptions for RAB3IP
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases FLJ14660 2 FLJ22548 2 MGC71495 2 OTTHUMP00000180672 2 RABIN3 1 , 2 Rabin-3 3
Descriptions RAB3A interacting protein 2 RAB3A interacting protein (rabin3) 2 SSX2 interacting protein 2 SSX2-interacting protein 3
Search outside databases for aliases for RAB3IP genePrevious GC identifers: GC00U991125 GC12U900020 GC12P069849
Summaries for RAB3IP (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Gene Wiki entry for RAB3IP
Genomic Location for RAB3IP
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the RAB3IP gene Entrez Gene cytogenetic band: 12q14.3 Ensembl cytogenetic band: 12q15 HGNC cytogenetic band: 12q14.3 RAB3IP Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12P068418:
(about GC identifiers )
Start:
68,418,898 bp from pter
End:
68,503,251 bp from pter
Size:
84,354 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000012.10 NT_029419.11 Proteins for RAB3IP
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: RAB3I_HUMAN, Q96QF0 (See
protein sequence )Recommended Name: RAB3A-interacting protein Size : 476 amino acids; 53021 Da
Subunit : Interacts with the N-terminal region of SSX2. Interacts with RAB3A and RAB3D
Subcellular location : Cytoplasm. Nucleus. Note=Predominantly cytoplasmic but a small proportioncolocalizes with SSX2 in the nucleus
Secondary accessions : Q6PCE4 Q96A24 Q96QE6 Q96QE7 Q96QE8 Q96QE9 Q96QF1 Q9H673Alternative splicing : 8 isoforms : Q96QF0-1 Q96QF0-2 Q96QF0-3 Q96QF0-4 Q96QF0-5 Q96QF0-6 Q96QF0-7 Q96QF0-8
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (5 alternative transcripts):
NP_001019818.1 NP_071901.2 NP_783322.1 NP_783323.1 NP_783324.1 ENSEMBL proteins: ENSP00000368092 ENSP00000377023 ENSP00000355381 ENSP00000323593 ENSP00000247833 ENSP00000323349 ENSP00000368086 Human Recombinant Proteins                OriGene Purified Recombinant Human Proteins (see all 2 ): RAB3IP 3 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for RAB3IP: Assays for RAB3IP:
Protein
Domains/ Families for RAB3IP(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q96QF0 ProtoNet protein and cluster: Q96QF0
UniProtKB/Swiss-Prot: RAB3I_HUMAN, Q96QF0 Similarity : Belongs to the SEC2 family
Gene Function for RAB3IP
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5 ): NM_022456 Applied Biosystems Silencer ® siRNAs for RAB3IP Sigma-Aldrich siRNA for RAB3IP Sigma-Aldrich shRNA for RAB3IP Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 5 ): NM_001024647                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 5 ): NM_001024647                                  untagged cDNA clones in CMV expression vector (see all 5 ): NM_001024647  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_175623
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Rab3ip) :2 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005085 guanyl-nucleotide exchange factor activity
IEA -- GO:0005515 protein binding
ISS --
About this table
Pathways & Interactions for RAB3IP
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for RAB3IP 5/9 Interacting proteins for RAB3IP (Q96QF0 1 , 2 ENSP00000323349 3 ) via UniProtKB, MINT, and/or STRING (see all 9
)About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0015031 protein transport
IEA --
About this table
Drugs & Compounds for RAB3IP (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Enzo Life Sciences drugs & compounds for RAB3IP
Browse Tocris compounds for RAB3IP
Transcripts for RAB3IP(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5 ): NM_022456 Sigma-Aldrich siRNA for RAB3IP Sigma-Aldrich shRNA for RAB3IP Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001024647 NM_022456 NM_175623 NM_175624 NM_175625
REFSEQ mRNAs for RAB3IP gene (5 alternative transcripts): NM_001024647.2 NM_022456.3 NM_175623.2 NM_175624.2 NM_175625.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001024647 NM_022456 NM_175623 NM_175624 NM_175625
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 5 ): NM_001024647                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 5 ): NM_001024647                                  untagged cDNA clones in CMV expression vector (see all 5 ): NM_001024647  
Additional cDNA sequence: AJ312896.1 AJ312897.1 AJ312898.1 AJ312899.1 AK026201.1 AK027566.1 AK027671.1 AK057844.1 AK123728.1 AK225441.1 AK314547.1 AY685922.1 BC014553.2 BC015548.1 BC039421.1 BC059358.1 BX537658.1 CR607211.1 CR616530.1
13 DOTS entries : DT.92443667 DT.302527 DT.97808259 DT.100774128 DT.99955221 DT.99976520 DT.95171517 DT.100774126 DT.92034033 DT.121188114 DT.97773063 DT.100720318 DT.121188052
24/157 AceView cDNA sequences (see all 157
):BU686797 AA809950 BF436325 CB105555 AL713462 AJ312897 AW292126 AI393299 BP371116 AJ312896 NM_175624 CR607211 AL532268 BG210226 NM_175623 AJ312899 AI654813 AV654488 NM_175625 BM554898 CR616530 AJ312898 AI680670 BX107864
highest scoring ESTs for RAB3IP :AI763164 AI961177 AL119897 AA314364 AA491041 AA846576 AA917731 AI205178 AI269686 AI478221
Unigene Cluster for RAB3IP: RAB3A interacting protein (rabin3) Hs.258209 [show with all ESTs ] Unigene Representative Sequence: NM_175623 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RAB3IP (see all 7
) ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 SP1 :   -       -   -   -             -         SP2 :         -   -   -             -         SP3 :         -   -   -             -   -       SP4 :         -   -   -         -   -   -         SP5 :             -             -        
About this scheme ECgene alternative splicing isoforms for RAB3IP 7 Ensembl transcripts including schematic representations : ENST00000378815
ENST00000393355
ENST00000362025
ENST00000325596
ENST00000247833
ENST00000325555
ENST00000378809
Expression for RAB3IP
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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RAB3IP expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for RAB3IP 1 / 2 / 3
15 probe-sets matching RAB3IP gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: ATTTCTTTTASOURCE GeneReport for Unigene cluster: Hs.258209 UniProtKB/Swiss-Prot: RAB3I_HUMAN, Q96QF0 Tissue specificity : Expressed in brain, kidney, heart, pancreas and placenta. Not detected inskeletal muscle or liver
Orthologs for RAB3IP
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for RAB3IP gene from 5/10 species (see all 10
)
About this table Species with no ortholog for RAB3IP ENSEMBL Gene Tree for RAB3IP Paralogs for RAB3IP (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for RAB3IP gene RAB3IL1 2
SNPs/Variants for RAB3IP (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for RAB3IP (up to first 250kb)
Disorders & Mutations for RAB3IP
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 608686
Medical News for RAB3IP (Possibly Related Articles in
Doctor's Guide )
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--
Publications for RAB3IP (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/13 PubMed articles for RAB3IP gene (see all 13
): The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. (PubMed id 12007189) 1, 3, 4 de Bruijn D.R.H....van Kessel A.G. (2002) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336) 4 Cantin G.T....Yates J.R. III (2008) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 4 Dephoure N.... Gygi S.P. (2008) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 3 Kimura K.... Sugano S. (2006) Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514) 3 Rual J.F....Vidal M. (2005) A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport. (PubMed id 12221131) 3 Hattula K....Peranen J. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002) Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149) 3 Suzuki Y.... Sugano S. (1997)
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Genome Databases showing RAB3IP
(According to
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euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing RAB3IP
(According to HUGE )
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Specialized Databases showing RAB3IP (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for RAB3IP (Reagents available from Applied Biosystems , Antibodies and assays by Cell
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