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Aliases for RAB3IP Gene

Aliases for RAB3IP Gene

  • RAB3A Interacting Protein 2 3 5
  • Rab3A-Interacting Protein 3 4
  • SSX2-Interacting Protein 3 4
  • Rabin-3 3 4
  • RABIN8 3 4
  • SSX2 Interacting Protein 3
  • Rabin3 2
  • RABIN3 3

External Ids for RAB3IP Gene

Previous GeneCards Identifiers for RAB3IP Gene

  • GC00U991125
  • GC12U900020
  • GC12P069849
  • GC12P068418
  • GC12P070132
  • GC12P067181

Summaries for RAB3IP Gene

GeneCards Summary for RAB3IP Gene

RAB3IP (RAB3A Interacting Protein) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Regulation of PLK1 Activity at G2/M Transition. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is RAB3IL1.

UniProtKB/Swiss-Prot for RAB3IP Gene

  • Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.

Gene Wiki entry for RAB3IP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB3IP Gene

Genomics for RAB3IP Gene

Regulatory Elements for RAB3IP Gene

Promoters for RAB3IP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAB3IP on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB3IP Gene

Chromosome:
12
Start:
69,738,400 bp from pter
End:
69,823,204 bp from pter
Size:
84,805 bases
Orientation:
Plus strand

Genomic View for RAB3IP Gene

Genes around RAB3IP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB3IP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB3IP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB3IP Gene

Proteins for RAB3IP Gene

  • Protein details for RAB3IP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QF0-RAB3I_HUMAN
    Recommended name:
    Rab-3A-interacting protein
    Protein Accession:
    Q96QF0
    Secondary Accessions:
    • B7WPJ6
    • Q6PCE4
    • Q96A24
    • Q96QE6
    • Q96QE7
    • Q96QE8
    • Q96QE9
    • Q96QF1
    • Q9H673

    Protein attributes for RAB3IP Gene

    Size:
    476 amino acids
    Molecular mass:
    53021 Da
    Quaternary structure:
    • Interacts with the N-terminal region of SSX2. Interacts with the GDP-bound forms of RAB3A, RAB3D, RAB8A and RAB8B.

    Three dimensional structures from OCA and Proteopedia for RAB3IP Gene

    Alternative splice isoforms for RAB3IP Gene

neXtProt entry for RAB3IP Gene

Proteomics data for RAB3IP Gene at MOPED

Post-translational modifications for RAB3IP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for RAB3IP Gene

Domains & Families for RAB3IP Gene

Protein Domains for RAB3IP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RAB3IP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96QF0

UniProtKB/Swiss-Prot:

RAB3I_HUMAN :
  • Belongs to the SEC2 family.
Family:
  • Belongs to the SEC2 family.
genes like me logo Genes that share domains with RAB3IP: view

No data available for Gene Families for RAB3IP Gene

Function for RAB3IP Gene

Molecular function for RAB3IP Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.
genes like me logo Genes that share phenotypes with RAB3IP: view

Animal Models for RAB3IP Gene

MGI Knock Outs for RAB3IP:

Animal Model Products

miRNA for RAB3IP Gene

miRTarBase miRNAs that target RAB3IP

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB3IP Gene

Localization for RAB3IP Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB3IP Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Note=Predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. Activation of protein kinase C results in redistribution to the periphery of lamellipodia. In the cytoskeleton, localizes to cortical actin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB3IP Gene COMPARTMENTS Subcellular localization image for RAB3IP gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
golgi apparatus 2
endosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RAB3IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12007189
GO:0036064 ciliary basal body TAS 17574030
genes like me logo Genes that share ontologies with RAB3IP: view

Pathways & Interactions for RAB3IP Gene

genes like me logo Genes that share pathways with RAB3IP: view

Gene Ontology (GO) - Biological Process for RAB3IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
genes like me logo Genes that share ontologies with RAB3IP: view

No data available for SIGNOR curated interactions for RAB3IP Gene

Drugs & Compounds for RAB3IP Gene

No Compound Related Data Available

Transcripts for RAB3IP Gene

Unigene Clusters for RAB3IP Gene

RAB3A interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB3IP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - -
SP6: -
SP7:

Relevant External Links for RAB3IP Gene

GeneLoc Exon Structure for
RAB3IP
ECgene alternative splicing isoforms for
RAB3IP

Expression for RAB3IP Gene

mRNA expression in normal human tissues for RAB3IP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB3IP Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.6) and Brain - Cerebellum (x4.8).

Protein differential expression in normal tissues from HIPED for RAB3IP Gene

This gene is overexpressed in Retina (29.5), Fetal Brain (9.1), Fetal ovary (9.0), and Islet of Langerhans (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB3IP Gene



SOURCE GeneReport for Unigene cluster for RAB3IP Gene Hs.258209

mRNA Expression by UniProt/SwissProt for RAB3IP Gene

Q96QF0-RAB3I_HUMAN
Tissue specificity: Expressed in brain, kidney, heart, pancreas and placenta. Not detected in skeletal muscle or liver.
genes like me logo Genes that share expression patterns with RAB3IP: view

Protein tissue co-expression partners for RAB3IP Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for RAB3IP Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB3IP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAB3IP 35
  • 93.12 (n)
  • 96.3 (a)
RAB3IP 36
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RAB3IP 35
  • 94.37 (n)
  • 96.79 (a)
-- 36
  • 97 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rab3ip 35
  • 84.97 (n)
  • 89.95 (a)
Rab3ip 16
Rab3ip 36
  • 90 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RAB3IP 35
  • 99.93 (n)
  • 100 (a)
RAB3IP 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab3ip 35
  • 85.14 (n)
  • 90.87 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 89 (a)
OneToMany
chicken
(Gallus gallus)
Aves RAB3IP 35
  • 82.08 (n)
  • 86.08 (a)
-- 36
  • 86 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 79 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rab3ip 35
  • 73.3 (n)
  • 78.77 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.11691 35
rab3ip 35
  • 66.67 (n)
  • 74.12 (a)
rab3ip 36
  • 71 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F54C9.11 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for RAB3IP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB3IP Gene

ENSEMBL:
Gene Tree for RAB3IP (if available)
TreeFam:
Gene Tree for RAB3IP (if available)

Paralogs for RAB3IP Gene

Paralogs for RAB3IP Gene

(1) SIMAP similar genes for RAB3IP Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with RAB3IP: view

Variants for RAB3IP Gene

Sequence variations from dbSNP and Humsavar for RAB3IP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs716362 -- 69,813,176(-) ATTAG(A/G)ACTAT intron-variant
rs1054880 -- 69,815,695(+) AAAAA(A/C)AAACC nc-transcript-variant, utr-variant-3-prime
rs1000783 -- 69,822,072(+) TATAG(G/T)GTGAT nc-transcript-variant, utr-variant-3-prime
rs1057617 -- 69,820,380(+) CTCTG(C/T)CCAAG nc-transcript-variant, utr-variant-3-prime
rs1135509 -- 69,820,508(+) AATGT(C/G)ACTTC nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RAB3IP Gene

Variant ID Type Subtype PubMed ID
esv1958700 CNV Deletion 18987734
esv2746020 CNV Deletion 23290073
nsv52529 CNV Loss 16902084

Variation tolerance for RAB3IP Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 40.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB3IP Gene

HapMap Linkage Disequilibrium report
RAB3IP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB3IP Gene

Disorders for RAB3IP Gene

Relevant External Links for RAB3IP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB3IP

No disorders were found for RAB3IP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB3IP Gene

Publications for RAB3IP Gene

  1. A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport. (PMID: 12221131) Hattula K. … Peranen J. (Mol. Biol. Cell 2002) 2 3 4 67
  2. The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. (PMID: 12007189) de Bruijn D.R.H. … van Kessel A.G. (Genes Chromosomes Cancer 2002) 3 23
  3. Activation of Rab8 guanine nucleotide exchange factor Rabin8 by ERK1/2 in response to EGF signaling. (PMID: 25535387) Wang J. … Guo W. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3

Products for RAB3IP Gene

Sources for RAB3IP Gene

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