Aliases for RAB3IP Gene
External Ids for RAB3IP Gene
Previous GeneCards Identifiers for RAB3IP Gene
GeneCards Summary for RAB3IP Gene
RAB3IP (RAB3A Interacting Protein) is a Protein Coding gene. Among its related pathways are Cargo trafficking to the periciliary membrane and Regulation of PLK1 Activity at G2/M Transition. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is RAB3IL1.
UniProtKB/Swiss-Prot for RAB3IP Gene
Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.