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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB3GAP1 Gene

protein-coding   GIFtS: 54
GCID: GC02P135809

RAB3 GTPase Activating Protein Subunit 1 (Catalytic)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAB3 GTPase Activating Protein Subunit 1 (Catalytic)1 2     WARBM12 5
Rab3-GAP P1302 3     RAB3GAP1302
RAB3GAP2 3     Rab3 GTPase-Activating Protein Catalytic Subunit2
RAB3 GTPase-Activating Protein 130 KDa Subunit2 3     KIAA00663
P1302 5     Rab3-GAP3

External Ids:    HGNC: 170631   Entrez Gene: 229302   Ensembl: ENSG000001158397   OMIM: 6025365   UniProtKB: Q150423   

Export aliases for RAB3GAP1 gene to outside databases

Previous GC identifers: GC02P135645 GC02U900802 GC02P135526 GC02P127801


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAB3GAP1 Gene:
This gene encodes the catalytic subunit of a Rab GTPase activating protein. The encoded protein forms a
heterodimer with a non-catalytic subunit to specifically regulate the activity of members of the Rab3 subfamily
of small G proteins. This protein mediates the hydrolysis of GTP bound Rab3 to the GDP bound form. Mutations in
this gene are associated with Warburg micro syndrome. Alternate splicing results in multiple transcript
variants.(provided by RefSeq, Feb 2010)

GeneCards Summary for RAB3GAP1 Gene: 
RAB3GAP1 (RAB3 GTPase activating protein subunit 1 (catalytic)) is a protein-coding gene. Diseases associated with RAB3GAP1 include micro syndrome, and warburg micro syndrome. GO annotations related to this gene include Rab GTPase activator activity and Rab GTPase binding.

UniProtKB/Swiss-Prot: RB3GP_HUMAN, Q15042
Function: Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily
(RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and
hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain
development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation
before synapse formation, and non-synaptic vesicular release of neurotransmitters

Gene Wiki entry for RAB3GAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022135.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB3GAP1 gene promoter:
         MEF-2   CUTL1   STAT5A   LCR-F1   MEF-2A   POU2F1   FOXC1   FOXO1a   aMEF-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB3GAP1 promoter sequence
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB3GAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.3   Ensembl cytogenetic band:  2q21.3   HGNC cytogenetic band: 2q21.3

RAB3GAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB3GAP1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P135809:  view genomic region     (about GC identifiers)

Start:
135,809,835 bp from pter      End:
135,933,964 bp from pter
Size:
124,130 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RB3GP_HUMAN, Q15042 (See protein sequence)
Recommended Name: Rab3 GTPase-activating protein catalytic subunit  
Size: 981 amino acids; 110524 Da
Subunit: The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and RAB3-GAP150. The Rab3
GTPase-activating complex interacts with DMXL2 (By similarity)
Subcellular location: Cytoplasm. Note=In neurons, it is enriched in the synaptic soluble fraction
Sequence caution: Sequence=CAH56411.1; Type=Erroneous initiation;
Secondary accessions: Q659F5 Q8TBB4
Alternative splicing: 2 isoforms:  Q15042-1   Q15042-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAB3GAP1: NX_Q15042

Explore proteomics data for RAB3GAP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15042

  • RAB3GAP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAB3GAP1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001165906.1  NP_036365.1  

    ENSEMBL proteins: 
     ENSP00000264158   ENSP00000411418   ENSP00000400761   ENSP00000444306  

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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--

    RAB3GAP1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026147 Rab3-GAP_cat_su

    Graphical View of Domain Structure for InterPro Entry Q15042

    ProtoNet protein and cluster: Q15042

    UniProtKB/Swiss-Prot: RB3GP_HUMAN, Q15042
    Similarity: Belongs to the Rab3-GAP catalytic subunit family


    RAB3GAP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RB3GP_HUMAN, Q15042
    Function: Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily
    (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and
    hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain
    development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation
    before synapse formation, and non-synaptic vesicular release of neurotransmitters
    Biophysicochemical properties: Kinetic parameters: KM=75 uM for GTP-loaded RAB3A;

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005097Rab GTPase activator activity IDA10859313
    GO:0017137Rab GTPase binding IPI10859313
         
    RAB3GAP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RAB3GAP1:
     Increased G1 DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rab3gap1):
     nervous system 

    RAB3GAP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rab3gap1tm1Tkss for RAB3GAP1

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB3GAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/21 Interacting proteins for RAB3GAP1 (Q150423 ENSP000002641584) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206289P287023I2D: score=1 
    ENSG00000227322P287023I2D: score=1 
    ENSG00000228333P287023I2D: score=1 
    ENSG00000231321P287023I2D: score=1 
    ENSG00000235712P287023I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007420brain development IMP--
    GO:0021854hypothalamus development IMP--
    GO:0032851positive regulation of Rab GTPase activity IDA10859313
    GO:0043010camera-type eye development IMP--
    GO:0043087regulation of GTPase activity IDA10859313

    RAB3GAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RAB3GAP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RAB3GAP1 (RB3GP)

    1 HMDB Compound for RAB3GAP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 Novoseek inferred chemical compound relationships for RAB3GAP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 71.2 7 12786944 (1), 9852129 (1), 16473606 (1), 11809763 (1)
    gtp 64.9 8 9224661 (1), 12786944 (1), 9852129 (1), 16473606 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about RAB3GAP1 / RB3GP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAB3GAP1 gene (2 alternative transcripts): 
    NM_001172435.1  NM_012233.2  

    Unigene Cluster for RAB3GAP1:

    RAB3 GTPase activating protein subunit 1 (catalytic)
    Hs.306327  [show with all ESTs]
    Unigene Representative Sequence: NM_001172435
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264158(uc010fnf.3 uc002tuj.3 uc010fng.3) ENST00000442034
    ENST00000425393 ENST00000487003(uc010fnh.1) ENST00000489858 ENST00000497080
    ENST00000539493
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    Additional mRNA sequence: 

    AB449877.1 AK022494.1 AK309118.1 BC020303.1 BC022977.1 BC030992.2 BC036732.1 BC071602.1 
    D31886.1 

    17 DOTS entries:

    DT.318550  DT.92042000  DT.100765793  DT.100692986  DT.120977449  DT.318552  DT.92432826  DT.92432825 
    DT.97826377  DT.95276239  DT.120977398  DT.120977404  DT.91863266  DT.95276242  DT.120977492  DT.91986408 
    DT.120977412 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RAB3GAP1 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16
    SP1:                                                                                                                                                      
    SP2:                    -                                                                                                                                 
    SP3:                                                                                                                                                      
    SP4:                                                                                                                                                      
    SP5:                                                                                                        -                                             


    ECgene alternative splicing isoforms for RAB3GAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB3GAP1 expression in normal human tissues (normalized intensities)      RAB3GAP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCTCAAGA
    RAB3GAP1 Expression
    About this image


    RAB3GAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Neural Crest (Gastrulation Derivatives)
             mesenchyme/trunk mesenchyme   
     
     Mesoderm (Gastrulation Derivatives)
             mesenchyme/trunk mesenchyme   
     
     Eye (Sensory Organs)
     
     Spinal Cord (Nervous System)

    See RAB3GAP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAB3GAP1

    SOURCE GeneReport for Unigene cluster: Hs.306327

    UniProtKB/Swiss-Prot: RB3GP_HUMAN, Q15042
    Tissue specificity: Ubiquitous

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RAB3GAP1 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab3gap11 , 5 RAB3 GTPase activating protein subunit 11, 5 87.11(n)1
    93.16(a)1
      1 (55.80 cM)5
    2264071  NM_178690.41  NP_848805.21 
     1278687735 
    chicken
    (Gallus gallus)
    Aves RAB3GAP11 RAB3 GTPase activating protein subunit 1 (catalytic) 80.3(n)
    87.28(a)
      424290  XM_003641627.1  XP_003641675.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAB3GAP16
    Uncharacterized protein
    85(a)
    1 ↔ 1
    1(96491978-96528350)
    zebrafish
    (Danio rerio)
    Actinopterygii rab3gap11 RAB3 GTPase activating protein subunit 1 66.8(n)
    74.3(a)
      777744  NM_001077788.2  NP_001071256.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG319351 CG31935 45.03(n)
    34.51(a)
      33338  NM_134764.2  NP_608608.2 
    worm
    (Caenorhabditis elegans)
    Secernentea rbg-11 Protein RBG-1 43.61(n)
    29.09(a)
      181595  NM_078089.2  NP_510490.1 


    ENSEMBL Gene Tree for RAB3GAP1 (if available)
    TreeFam Gene Tree for RAB3GAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2169 SNPs in RAB3GAP1 are shown (see all 2169)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1916101801,2
    --127828461(+) CCCCTC/GCCCTC 2 -- int10--------
    rs1820477211,2
    --135308253(+) TACCAC/GCAAAC 2 -- us2k10--------
    rs1998605261,2
    C--135308574(-) ACCCAA/CCAGCC 2 -- us2k10--------
    rs613690441,2
    C,F--135308645(+) CCAAAA/CACTGA 2 -- us2k12Minor allele frequency- C:0.05WA 120
    rs1382296301,2
    --135308656(+) GCAAAC/GAGTGA 2 -- us2k10--------
    rs1154667241,2
    F--135308709(+) TTGACG/AGAGCA 2 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1871812311,2
    --135308789(+) CAGAGA/CCTTCG 2 -- us2k10--------
    rs778281841,2
    F--135308870(+) GCAGAG/ATGGGA 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1916219681,2
    --135309012(+) CCGAGA/GGGGGC 2 -- us2k10--------
    rs783041671,2
    C--135309084(+) AAAAAC/TACAAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAB3GAP1 (135809835 - 135933964 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RAB3GAP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834386CNV Gain17160897


    Human Gene Mutation Database (HGMD): RAB3GAP1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RAB3GAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for RAB3GAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602536   
    OMIM disorders: 600118  
    UniProtKB/Swiss-Prot: RB3GP_HUMAN, Q15042
  • Warburg micro syndrome 1 (WARBM1) [MIM:600118]: A rare syndrome characterized by microcephaly,
    microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus
    callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 20/21 diseases for RAB3GAP1 (see all 21):    About MalaCards
    micro syndrome    warburg micro syndrome    warburg micro syndrome 1    martsolf syndrome
    spastic diplegia    pseudobulbar palsy    periventricular nodular heterotopia    optic atrophy
    human t-cell leukemia virus type 1    hypogonadism    keratoconus    microphthalmia
    microcephaly    cataract    intellectual disability    spasticity
    t-cell leukemia    mental retardation    leukemia    pancreatitis

    3 diseases from the University of Copenhagen DISEASES database for RAB3GAP1:
    Spastic diplegia     Microcephaly     Microphthalmia

    RAB3GAP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RAB3GAP1

    Export disorders for RAB3GAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB3GAP1 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with RAB3GAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations of the catalytic subunit of RAB3GAP cause Warburg Micro syndrome. (PubMed id 15696165)1, 2, 3, 9 Aligianis I.A....Maher E.R. (2005)
    2. Isolation and characterization of a GTPase activating protein specific for the Rab3 subfamily of small G proteins. (PubMed id 9030515)1, 2, 3, 9 Fukui K.... Takai Y. (1997)
    3. Biochemical characterization of Rab3-GTPase-activating protein reveals a mechanism similar to that of Ras-GAP. (PubMed id 10859313)1, 2, 9 Clabecq A.... Darchen F. (2000)
    4. Localization of the Rab3 small G protein regulators in nerve terminals and their involvement in Ca2+-dependent exocytosis. (PubMed id 9852129)1, 2, 9 Oishi H.... Takai Y. (1998)
    5. Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (2010)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2 Nomura N....Tabata S. (1994)
    9. A novel rabconnectin-3-binding protein that directly binds a GDP/GTP exchange protein for Rab3A small G protein implicated in Ca(2+)- dependent exocytosis of neurotransmitter. (PubMed id 12786944)1, 9 Kawabe H.... Takai Y. (2003)
    10. Phenotypic variability in Micro syndrome: report of new cases. (PubMed id 18286824)1, 9 Abdel-Salam G.M....Aligianis I.A. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22930 HGNC: 17063 Ensembl:ENSG00000115839 euGenes: HUgn22930 ECgene: RAB3GAP1
    H-InvDB: RAB3GAP1

    (According to HUGE)
    About This Section
    HUGE: KIAA0066

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB3GAP1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/RAB3GAP1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAB3GAP1 gene:
    Search GeneIP for patents involving RAB3GAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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