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Aliases for RAB3D Gene

Aliases for RAB3D Gene

  • RAB3D, Member RAS Oncogene Family 2 3
  • GOV 3 4 6
  • Rab3D Upregulated With Myeloid Differentiation 2 3
  • Glioblastoma Overexpressed 2 3
  • RAD3D 3 6
  • RAB16 3 4
  • Ras-Related Protein Rab-3D 3
  • D2-2 3

External Ids for RAB3D Gene

Previous Symbols for RAB3D Gene

  • GOV

Summaries for RAB3D Gene

GeneCards Summary for RAB3D Gene

RAB3D (RAB3D, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB3D include glioblastoma. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Pancreatic secretion. GO annotations related to this gene include GTP binding and GTPase binding. An important paralog of this gene is RAB37.

UniProtKB/Swiss-Prot for RAB3D Gene

  • Protein transport. Probably involved in regulated exocytosis (By similarity).

Gene Wiki entry for RAB3D Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB3D Gene

Genomics for RAB3D Gene

Genomic Location for RAB3D Gene

Start:
11,322,046 bp from pter
End:
11,346,270 bp from pter
Size:
24,225 bases
Orientation:
Minus strand

Genomic View for RAB3D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB3D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB3D Gene

Regulatory Elements for RAB3D Gene

Proteins for RAB3D Gene

  • Protein details for RAB3D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95716-RAB3D_HUMAN
    Recommended name:
    Ras-related protein Rab-3D
    Protein Accession:
    O95716
    Secondary Accessions:

    Protein attributes for RAB3D Gene

    Size:
    219 amino acids
    Molecular mass:
    24267 Da
    Quaternary structure:
    • Interacts with RIMS1, RIMS2, RPH3A, RPH3AL and RAB3IP.

    Three dimensional structures from OCA and Proteopedia for RAB3D Gene

neXtProt entry for RAB3D Gene

Proteomics data for RAB3D Gene at MOPED

Post-translational modifications for RAB3D Gene

No Post-translational modifications

Other Protein References for RAB3D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB3D Gene

Domains for RAB3D Gene

Gene Families for RAB3D Gene

HGNC:
  • RAB :RAB, member RAS oncogene

UniProtKB/Swiss-Prot:

RAB3D_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rab family.:
    • O95716
genes like me logo Genes that share domains with RAB3D: view

Function for RAB3D Gene

Molecular function for RAB3D Gene

UniProtKB/Swiss-Prot Function: Protein transport. Probably involved in regulated exocytosis (By similarity).
UniProtKB/Swiss-Prot Induction: Activated in myeloid differentiation

Gene Ontology (GO) - Molecular Function for RAB3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 10023084
GO:0005515 protein binding --
GO:0005525 GTP binding IEA --
GO:0031489 myosin V binding IPI 24006491
GO:0051020 GTPase binding IEA --
genes like me logo Genes that share ontologies with RAB3D: view
genes like me logo Genes that share phenotypes with RAB3D: view

Animal Models for RAB3D Gene

MGI Knock Outs for RAB3D:

miRNA for RAB3D Gene

miRTarBase miRNAs that target RAB3D

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RAB3D Gene

Localization for RAB3D Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB3D Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB3D Gene COMPARTMENTS Subcellular localization image for RAB3D gene
Compartment Confidence
plasma membrane 5
cytosol 3
mitochondrion 2
cytoskeleton 1
extracellular 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RAB3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IEA --
GO:0005768 endosome IBA --
genes like me logo Genes that share ontologies with RAB3D: view

Pathways for RAB3D Gene

genes like me logo Genes that share pathways with RAB3D: view

Pathways by source for RAB3D Gene

1 Qiagen pathway for RAB3D Gene
1 KEGG pathway for RAB3D Gene

Gene Ontology (GO) - Biological Process for RAB3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006887 exocytosis --
GO:0006904 vesicle docking involved in exocytosis IBA --
GO:0006913 nucleocytoplasmic transport --
genes like me logo Genes that share ontologies with RAB3D: view

Transcripts for RAB3D Gene

mRNA/cDNA for RAB3D Gene

Unigene Clusters for RAB3D Gene

RAB3D, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB3D Gene

No ASD Table

Relevant External Links for RAB3D Gene

GeneLoc Exon Structure for
RAB3D
ECgene alternative splicing isoforms for
RAB3D

Expression for RAB3D Gene

mRNA expression in normal human tissues for RAB3D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB3D Gene

This gene is overexpressed in Whole Blood (11.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB3D Gene

SOURCE GeneReport for Unigene cluster for RAB3D Gene Hs.744916

mRNA Expression by UniProt/SwissProt for RAB3D Gene

O95716-RAB3D_HUMAN
Tissue specificity: Highly expressed in granulocytes of peripheral blood. Constitutively expressed at low levels in all hematopoietic cell lines investigated
genes like me logo Genes that share expressions with RAB3D: view

Orthologs for RAB3D Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB3D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB3D 36
  • 99.09 (n)
  • 99.54 (a)
RAB3D 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB3D 36
  • 90.56 (n)
  • 94.98 (a)
RAB3D 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB3D 36
  • 88.89 (n)
  • 94.98 (a)
RAB3D 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab3d 36
  • 87.21 (n)
  • 94.52 (a)
Rab3d 16
Rab3d 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB3D 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB3D 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab3d 36
  • 87.37 (n)
  • 92.69 (a)
lizard
(Anolis carolinensis)
Reptilia RAB3D 37
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab3d 36
  • 75.77 (n)
  • 80.09 (a)
Str.4787 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4063 36
zebrafish
(Danio rerio)
Actinopterygii rab3da 36
  • 72.6 (n)
  • 79.91 (a)
rab3da 37
  • 78 (a)
OneToMany
rab3db 37
  • 76 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Rab3 37
  • 75 (a)
OneToMany
Rab3 38
  • 74 (a)
worm
(Caenorhabditis elegans)
Secernentea rab-3 37
  • 67 (a)
OneToMany
rab-3 38
  • 73 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 74 (a)
OneToMany
Species with no ortholog for RAB3D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB3D Gene

ENSEMBL:
Gene Tree for RAB3D (if available)
TreeFam:
Gene Tree for RAB3D (if available)

Paralogs for RAB3D Gene

Paralogs for RAB3D Gene

genes like me logo Genes that share paralogs with RAB3D: view

Variants for RAB3D Gene

Sequence variations from dbSNP and Humsavar for RAB3D Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs172731 -- 11,336,275(+) TTCCC(C/T)GTTGG intron-variant
rs178418 -- 11,336,355(+) ccatg(A/C)tggaa intron-variant
rs186421 -- 11,336,366(+) tgcag(C/T)ggtgc intron-variant
rs316504 -- 11,335,295(+) ATCCC(A/C)TGCAA intron-variant
rs316505 -- 11,335,877(+) CCCAG(C/T)CTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB3D Gene

Variant ID Type Subtype PubMed ID
nsv833752 CNV Loss 17160897
nsv519802 CNV Loss 19592680

Relevant External Links for RAB3D Gene

HapMap Linkage Disequilibrium report
RAB3D

Disorders for RAB3D Gene

(1) MalaCards Diseases for RAB3D Gene

Search for RAB3D Gene in MalaCards »

(1) University of Copenhagen DISEASES for RAB3D Gene

Relevant External Links for RAB3D

Genetic Association Database (GAD)
RAB3D
Human Genome Epidemiology (HuGE) Navigator
RAB3D
genes like me logo Genes that share disorders with RAB3D: view

No data available for UniProtKB/Swiss-Prot for RAB3D Gene

Publications for RAB3D Gene

  1. Molecular cloning of cDNA encoding human Rab3D whose expression is upregulated with myeloid differentiation. (PMID: 10023084) Nishio H. … Yamaguchi Y. (Biochim. Biophys. Acta 1999) 2 3 4 23
  2. Rab3D and annexin A2 play a role in regulated secretion of vWF, but not tPA, from endothelial cells. (PMID: 15257287) Knop M. … Gerke V. (EMBO J. 2004) 3 23
  3. Assignment of the GOV (Glioblastoma overexpressed) gene to human chromosome band 19p13.2 by fluorescence in situ hybridization. (PMID: 10072586) Chen X.N. … Sehgal A. (Cytogenet. Cell Genet. 1998) 2 3
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RAB3D Gene

Sources for RAB3D Gene

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