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Aliases & Descriptions for RAB3D
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| RAB3D, member RAS oncogene family 2 | | Rab3D upregulated with myeloid differentiation 2 | | glioblastoma overexpressed 2 |
|
| | Search outside databases for aliases for RAB3D genePrevious GC identifers: GC19M011566 GC19M011655 GC19M011280 |
Summaries for RAB3D(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: RAB3D_HUMAN, O95716Function: Protein transport. Probably involved in regulated exocytosis (By similarity)Gene Wiki entry for RAB3D |
Genomic Location for RAB3D
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RAB3D gene 
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2RAB3D Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M011296:
(about GC identifiers)
Start:
|
11,296,093 bp from pter |
End:
|
11,311,321 bp from pter |
Size:
|
15,229 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011295.10
| Proteins for RAB3D
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RAB3D_HUMAN, O95716 (See
protein sequence)Recommended Name: Ras-related protein Rab-3D Size: 219 amino acids; 24267 Da
Subunit: Binds RIMS1. Interacts with RAB3IP (By similarity)
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
PDB structures from and Proteopedia :2GF9 (3D)
 REFSEQ proteins: NP_004274.1
ENSEMBL proteins: ENSP00000222120
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | About this table
Antibodies for RAB3D: Assays for RAB3D: | Protein
Domains/ Families for RAB3D(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O95716
ProtoNet protein and cluster: O95716 1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: RAB3D_HUMAN, O95716Similarity: Belongs to the small GTPase superfamily. Rab family | Gene Function for RAB3D
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004283
Applied Biosystems Silencer® siRNAs for RAB3D
Sigma-Aldrich siRNA for RAB3D  Sigma-Aldrich shRNA for RAB3D  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004283                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004283                                  untagged cDNA clones in CMV expression vector (see all 2): NM_004283 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004283
UniProtKB/Swiss-Prot: RAB3D_HUMAN, O95716Function: Protein transport. Probably involved in regulated exocytosis (By similarity)Induction: Activated in myeloid differentiation7 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Rab3d):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for RAB3D
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for RAB3D 
5/9 Interacting proteins for RAB3D (ENSP000002221203) via UniProtKB, MINT, and/or STRING (see all 9
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006887 | exocytosis |
IEA | -- | | GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- | About this table
|
Drugs & Compounds for RAB3D(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for RAB3D |
Browse Tocris compounds for RAB3D
|
Transcripts for RAB3D(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004283
Sigma-Aldrich siRNA for RAB3D  Sigma-Aldrich shRNA for RAB3D  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004283 REFSEQ mRNAs for RAB3D gene: NM_004283.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004283               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004283                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004283                                  untagged cDNA clones in CMV expression vector (see all 2): NM_004283  Additional cDNA sequence: AF019226.1 AF081353.1 AF498933.1 AK313538.1 BC007960.2 BC016471.1 BC035309.1 7 DOTS entries: DT.95167487 DT.91754714 DT.121497451 DT.121497438 DT.75107864 DT.100661499 DT.92440280 24/424 AceView cDNA sequences (see all 424
):AI280176 AA402328 AI559369 BX091064 AI192573 BM764630 CD671556 BU179008 BE889078 AA303056 CA943917 BM709889 BM853995 CK299243 AI434953 AA298311 AA411457 BX509018 AI140421 AI937180 AA595980 W67281 BM974589 BE645743
highest scoring ESTs for RAB3D:AF081353 BC016471 BF038343 BI910348 BX281152 CB960016 CB960882 CB989112 CD109583 CN285981 Unigene Cluster for RAB3D: RAB3D, member RAS oncogene family Hs.655274 [show with all ESTs]Unigene Representative Sequence: AF019226
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000222120
|
Expression for RAB3D
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RAB3D expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RAB3D
1 / 2 / 3 6 probe-sets matching RAB3D gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ACCACAGGGG
SOURCE GeneReport for Unigene cluster: Hs.655274 UniProtKB/Swiss-Prot: RAB3D_HUMAN, O95716Tissue specificity: Highly expressed in granulocytes of peripheral blood. Constitutively expressed at low levels in all hematopoietic cell lines invstigated |
Orthologs for RAB3D
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB3D gene from 5/10 species (see all 10
)
About this table Species with no ortholog for RAB3D
ENSEMBL Gene Tree for RAB3D | Paralogs for RAB3D(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RAB3D gene
- RAB3A2 RAB3B2 RAB122 RAB3C2
|
SNPs/Variants for RAB3D(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RAB3D (up to first 250kb)
|
Disorders & Mutations for RAB3D
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604350
|
Medical News for RAB3D(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RAB3D (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/25 PubMed articles for RAB3D gene (see all 25
):- Molecular cloning of cDNA encoding human Rab3D whose expression is upregulated with myeloid differentiation. (PubMed id 10023084)1, 2, 3, 4 Nishio H.... Yamaguchi Y. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Assignment of the GOV (Glioblastoma overexpressed) gene to human chromosome band 19p13.2 by fluorescence in situ hybridization. (PubMed id 10072586)2, 3 Chen X.N....Sehgal A. (1998)
- Rab3D and annexin A2 play a role in regulated secretion of vWF, but not tPA, from endothelial cells. (PubMed id 15257287)1, 3 Knop M....Gerke V. (2004)
- Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. (PubMed id 15159548)3 Matsumoto M....Seino S. (2004)
- Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. (PubMed id 12578829)3 Fukuda M. (2003)
- Rab3D redistribution and function in rat parotid acini. (PubMed id 14566969)3 Nguyen D....Ngyen D. (2003)
- Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through Akt. (PubMed id 11903042)3 Cartel N.J....Post M. (2002)
- Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules. (PubMed id 12192047)3 Riedel D....Jahn R. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for RAB3D
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RAB3D
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RAB3D
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB3D(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RAB3D(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RAB3D:

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