RAB3D Gene
protein-coding GIFtS: 56
GCID: GC19M011435
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RAB3D, member RAS oncogene family
(Previous symbol: GOV)
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Aliases
for RAB3D gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RAB3D, Member RAS Oncogene Family1 2 | | D2-21 2 | | GOV1 2 3 5 | | Glioblastoma Overexpressed2 | | RAB161 2 3 | | Rab3D Upregulated With Myeloid Differentiation2 | | RAD3D1 2 5 | | Ras-Related Protein Rab-3D2 |
Export aliases for RAB3D gene to outside databasesPrevious GC identifers: GC19M011566 GC19M011655 GC19M011280 GC19M011296 GC19M011008 |
Summaries
for RAB3D gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RAB3D_HUMAN, O95716Function: Protein transport. Probably involved in regulated exocytosis (By similarity)
Gene Wiki entry for RAB3D
|
Genomic Views
for RAB3D gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAB3D gene promoter:
E2F-4 E2F-3a E2F-5 E2F-2 Egr-4 c-Ets-1 HEN1 E2F E2F-1 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAB3D
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB3D |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2RAB3D Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M011435: view genomic region
(about GC identifiers)
Start:
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11,432,722 bp from pter |
End:
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11,456,946 bp from pter |
Size:
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24,225 bases |
Orientation:
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minus strand |
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Proteins
for RAB3D gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RAB3D_HUMAN, O95716 (See
protein sequence)Recommended Name: Ras-related protein Rab-3D Size: 219 amino acids; 24267 Da
Subunit: Interacts with RIMS1, RIMS2, RPH3A, RPH3AL and RAB3IP (By similarity)
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
1 PDB 3D structure from  and Proteopedia  for RAB3D:2GF9 (3D)
Explore the universe of human proteins at neXtProt for RAB3D: NX_O95716
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95716
RAB3D Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004274.1
ENSEMBL proteins: ENSP00000222120 ENSP00000466000
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
RAB3D for ontologies About GeneDecksing
RAB3D Antibody Products:
Assay Products for RAB3D: |
Protein
Domains /
Families
for RAB3D gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAB3D for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95716ProtoNet protein and cluster: O95716 1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: RAB3D_HUMAN, O95716Similarity: Belongs to the small GTPase superfamily. Rab family |
Function
for RAB3D gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RAB3D_HUMAN, O95716Function: Protein transport. Probably involved in regulated exocytosis (By similarity)Induction: Activated in myeloid differentiation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB3D (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB3D (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB3D |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
RAB3D for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RAB3D:
Animal Models:
Mouse knock-out Rab3dtm1Rja for RAB3D
7 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Rab3d):
RAB3D for phenotypes About GeneDecksing
|
Pathways & Interactions
for RAB3D gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Pancreatic secretion | | | 2 | Sertoli-Sertoli Cell Junction Dynamics | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB3D
1 
Kegg Pathway (Kegg details for RAB3D):
RAB3D for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB3D
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/15 Interacting proteins for RAB3D (O957163 ENSP000002221204) via UniProtKB, MINT, STRING, and/or I2D (see all 15)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
RAB3D for ontologies About GeneDecksing
|
Drugs & Compounds
for RAB3D gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RAB3D
Search CenterWatch for drugs/clinical trials and news about RAB3D
|
Transcripts
for RAB3D gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RAB3D gene: NM_004283.3 Unigene Cluster for RAB3D: RAB3D, member RAS oncogene family Hs.655274 [show with all ESTs]Unigene Representative Sequence: NM_0042832 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000222120(uc002mqx.3) ENST00000589655
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB3D (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB3D (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RAB3D (NM_004283) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAB3D | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB3D |
Additional cDNA sequence: AF019226.1 AF081353.1 AF498933.1 AK313538.1 BC007960.2 BC016471.1 BC035309.1 5 DOTS entries: DT.95167487 DT.91754714 DT.121497451 DT.121497438 DT.75107864 24/424 AceView cDNA sequences (see all 424): BX091064 CD671556 BU179008 AI263686 AI281075 BI758107 AI682860 AA303056 BQ478425 AW339544 BU848874 BM915318 AA722856 AI950072 BE252952 AA987561 BU553324 BG686756 AA296812 AA938296 AA595980 AA814648 AI937180 CB242344
GeneLoc Exon Structure
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Expression
for RAB3D gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RAB3D expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCACAGGGG
About this image
See RAB3D Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAB3D
SOURCE GeneReport for Unigene cluster: Hs.655274
UniProtKB/Swiss-Prot: RAB3D_HUMAN, O95716Tissue specificity: Highly expressed in granulocytes of peripheral blood. Constitutively expressed at low levels in allhematopoietic cell lines investigated
SABiosciences Custom PCR Arrays for RAB3D
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB3D
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAB3D | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB3D | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB3D | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB3D |
Orthologs
for RAB3D gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RAB3D gene from 7/26 species (see all 26) About this table
ENSEMBL Gene Tree for RAB3D (if available)
TreeFam Gene Tree for RAB3D (if available) |
Paralogs
for RAB3D gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RAB3D gene
- RAB232 RAB27A2 RAB3A2 RAB3B2 RAB27B2 RAB3C2
18/86 SIMAP similar genes for RAB3D using alignment to 1 protein entry: RAB3D_HUMAN(see all similar genes):RAB3A RAB3B RAB3C RAB8B RAB10 RAB35
RAB8A RAB30 RAB27A RAB1C RAB11A RAB13
RAB15 DKFZp686J07132 RAB11B RAB27B RAB39B RAB23
RAB3D for paralogs About GeneDecksing
|
Genomic Variants
for RAB3D gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RAB3D (11432722 - 11456946 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RAB3D: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB3D |
|
Disorders
/ Diseases
for RAB3D gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RAB3D for disorders About GeneDecksing
OMIM gene information: 604350
OMIM disorders: --
7  diseases for RAB3D: About MalaCardsglioblastoma vericose veins tumor of exocrine pancreas esophageal varix
esophagitis pancreatitis neuronitis
1 disease from the University of Copenhagen DISEASES database for RAB3D:Varicose veins Human Genome Epidemiology (HuGE) Navigator: RAB3D (1 document)
Export disorders for RAB3D gene to outside databases
|
Publications
for RAB3D gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RAB3D gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with RAB3D) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of cDNA encoding human Rab3D whose expression is upregulated with myeloid differentiation. (PubMed id 10023084)1, 2, 3, 9 Nishio H.... Yamaguchi Y. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Assignment of the GOV (Glioblastoma overexpressed) gene to human chromosome band 19p13.2 by fluorescence in situ hybridization. (PubMed id 10072586)1, 3 Chen X.N....Sehgal A. (1998)
- Rab3D and annexin A2 play a role in regulated secretion of vWF, but not tPA, from endothelial cells. (PubMed id 15257287)1, 9 Knop M....Gerke V. (2004)
- Changes in Rab3D expression and distribution in the ac ini of Sjogren's syndrome patients are associated with loss of cell polarity and secretory dysfunction. (PubMed id 21702009)1 Bahamondes V....Gonzalez M.J. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactome mapping suggests new mechanistic details u nderlying Alzheimer's disease. (PubMed id 21163940)1 Soler-Lopez M....Aloy P. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation. (PubMed id 20038531)1 Tian X....Mills J.C. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
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External Searches for RAB3D gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RAB3D gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RAB3D gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB3D gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RAB3D gene:
Search GeneIP for patents involving RAB3D
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RAB3D gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for RAB3D | | OriGene shRNA RFP for RAB3D | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB3D | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB3D | | | OriGene Protein Over-expression Lysate for RAB3D | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RAB3D | | OriGene 3'-UTR Clone for RAB3D | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB3D | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB3D | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RAB3D | | OriGene Custom Protein Services for RAB3D | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAB3D | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB3D | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB3D | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB3D | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB3D | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB3D |
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| |  |  |  |  | | | | | | Recombinant Protein for RAB3D |
|
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 | | | RAB3D Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB3D |
|  |  |  | | | | Search ThermoFisher Antibodies for RAB3D |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB3D |
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