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Aliases for RAB3D Gene

Aliases for RAB3D Gene

  • RAB3D, Member RAS Oncogene Family 2 3 5
  • Rab3D Upregulated With Myeloid Differentiation 2 3
  • Glioblastoma Overexpressed 2 3
  • RAB16 3 4
  • GOV 3 4
  • RAD3D 3
  • D2-2 3

External Ids for RAB3D Gene

Previous HGNC Symbols for RAB3D Gene

  • GOV

Previous GeneCards Identifiers for RAB3D Gene

  • GC19M011566
  • GC19M011655
  • GC19M011280
  • GC19M011296
  • GC19M011435
  • GC19M011008

Summaries for RAB3D Gene

GeneCards Summary for RAB3D Gene

RAB3D (RAB3D, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB3D include Tumor Of Exocrine Pancreas. Among its related pathways are Pancreatic secretion and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and GTPase binding. An important paralog of this gene is RAB37.

UniProtKB/Swiss-Prot for RAB3D Gene

  • Protein transport. Probably involved in regulated exocytosis (By similarity).

Gene Wiki entry for RAB3D Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB3D Gene

Genomics for RAB3D Gene

Regulatory Elements for RAB3D Gene

Enhancers for RAB3D Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RAB3D on UCSC Golden Path with GeneCards custom track

Promoters for RAB3D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAB3D on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB3D Gene

11,322,046 bp from pter
11,346,270 bp from pter
24,225 bases
Minus strand

Genomic View for RAB3D Gene

Genes around RAB3D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB3D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB3D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB3D Gene

Proteins for RAB3D Gene

  • Protein details for RAB3D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-3D
    Protein Accession:

    Protein attributes for RAB3D Gene

    219 amino acids
    Molecular mass:
    24267 Da
    Quaternary structure:
    • Interacts with RIMS1, RIMS2, RPH3A, RPH3AL and RAB3IP.

    Three dimensional structures from OCA and Proteopedia for RAB3D Gene

neXtProt entry for RAB3D Gene

Proteomics data for RAB3D Gene at MOPED

Post-translational modifications for RAB3D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB3D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB3D Gene

Domains & Families for RAB3D Gene

Gene Families for RAB3D Gene

Suggested Antigen Peptide Sequences for RAB3D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB3D: view

Function for RAB3D Gene

Molecular function for RAB3D Gene

UniProtKB/Swiss-Prot Function:
Protein transport. Probably involved in regulated exocytosis (By similarity).
UniProtKB/Swiss-Prot Induction:
Activated in myeloid differentiation.

Gene Ontology (GO) - Molecular Function for RAB3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
genes like me logo Genes that share ontologies with RAB3D: view
genes like me logo Genes that share phenotypes with RAB3D: view

Animal Models for RAB3D Gene

MGI Knock Outs for RAB3D:

Animal Model Products

  • Taconic Biosciences Mouse Models for RAB3D

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB3D Gene

Localization for RAB3D Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB3D Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for RAB3D Gene COMPARTMENTS Subcellular localization image for RAB3D gene
Compartment Confidence
cytoskeleton 5
extracellular 5
cytosol 4
plasma membrane 4
mitochondrion 3
golgi apparatus 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RAB3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0030133 transport vesicle IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with RAB3D: view

Pathways & Interactions for RAB3D Gene

genes like me logo Genes that share pathways with RAB3D: view

Pathways by source for RAB3D Gene

1 KEGG pathway for RAB3D Gene
1 Qiagen pathway for RAB3D Gene

Gene Ontology (GO) - Biological Process for RAB3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045453 bone resorption IDA 21262767
genes like me logo Genes that share ontologies with RAB3D: view

No data available for SIGNOR curated interactions for RAB3D Gene

Drugs & Compounds for RAB3D Gene

No Compound Related Data Available

Transcripts for RAB3D Gene

mRNA/cDNA for RAB3D Gene

Unigene Clusters for RAB3D Gene

RAB3D, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB3D Gene

No ASD Table

Relevant External Links for RAB3D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB3D Gene

mRNA expression in normal human tissues for RAB3D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB3D Gene

This gene is overexpressed in Whole Blood (x11.2).

Protein differential expression in normal tissues from HIPED for RAB3D Gene

This gene is overexpressed in Frontal cortex (14.2), Oral epithelium (7.8), Brain (7.3), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB3D Gene

SOURCE GeneReport for Unigene cluster for RAB3D Gene Hs.744916

mRNA Expression by UniProt/SwissProt for RAB3D Gene

Tissue specificity: Highly expressed in granulocytes of peripheral blood. Constitutively expressed at low levels in all hematopoietic cell lines investigated.
genes like me logo Genes that share expression patterns with RAB3D: view

Protein tissue co-expression partners for RAB3D Gene

Primer Products

Orthologs for RAB3D Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB3D Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RAB3D 35
  • 90.56 (n)
  • 94.98 (a)
RAB3D 36
  • 95 (a)
(Canis familiaris)
Mammalia RAB3D 35
  • 88.89 (n)
  • 94.98 (a)
RAB3D 36
  • 90 (a)
(Mus musculus)
Mammalia Rab3d 35
  • 87.21 (n)
  • 94.52 (a)
Rab3d 16
Rab3d 36
  • 95 (a)
(Pan troglodytes)
Mammalia RAB3D 35
  • 99.09 (n)
  • 99.54 (a)
RAB3D 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rab3d 35
  • 87.37 (n)
  • 92.69 (a)
(Monodelphis domestica)
Mammalia RAB3D 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia RAB3D 36
  • 88 (a)
(Anolis carolinensis)
Reptilia RAB3D 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab3d 35
  • 75.77 (n)
  • 80.09 (a)
Str.4787 35
(Danio rerio)
Actinopterygii rab3da 35
  • 72.6 (n)
  • 79.91 (a)
rab3da 36
  • 78 (a)
rab3db 36
  • 76 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4063 35
fruit fly
(Drosophila melanogaster)
Insecta Rab3 37
  • 74 (a)
Rab3 36
  • 75 (a)
(Caenorhabditis elegans)
Secernentea rab-3 37
  • 73 (a)
rab-3 36
  • 67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 74 (a)
Species with no ortholog for RAB3D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB3D Gene

Gene Tree for RAB3D (if available)
Gene Tree for RAB3D (if available)

Paralogs for RAB3D Gene

genes like me logo Genes that share paralogs with RAB3D: view

Variants for RAB3D Gene

Sequence variations from dbSNP and Humsavar for RAB3D Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3969860 - 11,337,210(+) GTAGA(C/T)GGTCT reference, missense
rs7257984 -- 11,329,878(+) ggttt(C/T)accat intron-variant
rs12986264 -- 11,336,778(+) agcct(A/G)gccaa intron-variant
rs13343708 -- 11,340,801(+) aatat(A/C)caaaa upstream-variant-2KB
rs13343763 -- 11,341,136(+) tggcc(A/C)caaaa upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RAB3D Gene

Variant ID Type Subtype PubMed ID
nsv833752 CNV Loss 17160897
nsv519802 CNV Loss 19592680

Variation tolerance for RAB3D Gene

Residual Variation Intolerance Score: 68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.77; 58.00% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RAB3D Gene

Disorders for RAB3D Gene

MalaCards: The human disease database

(1) MalaCards diseases for RAB3D Gene - From: DISEASES

Disorder Aliases PubMed IDs
tumor of exocrine pancreas
  • malignant neoplasm of the exocrine pancreas
- elite association - COSMIC cancer census association via MalaCards
Search RAB3D in MalaCards View complete list of genes associated with diseases

Relevant External Links for RAB3D

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RAB3D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB3D Gene

Publications for RAB3D Gene

  1. Molecular cloning of cDNA encoding human Rab3D whose expression is upregulated with myeloid differentiation. (PMID: 10023084) Nishio H. … Yamaguchi Y. (Biochim. Biophys. Acta 1999) 2 3 4 23 67
  2. Rab3D and annexin A2 play a role in regulated secretion of vWF, but not tPA, from endothelial cells. (PMID: 15257287) Knop M. … Gerke V. (EMBO J. 2004) 3 23
  3. Assignment of the GOV (Glioblastoma overexpressed) gene to human chromosome band 19p13.2 by fluorescence in situ hybridization. (PMID: 10072586) Chen X.N. … Sehgal A. (Cytogenet. Cell Genet. 1998) 2 3
  4. High expression of small GTPase Rab3D promotes cancer progression and metastasis. (PMID: 25823663) Yang J. … Luo Y. (Oncotarget 2015) 3
  5. Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. (PMID: 23505323) Weissglas-Volkov D. … Pajukanta P. (J. Med. Genet. 2013) 3

Products for RAB3D Gene

Sources for RAB3D Gene