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Aliases for RAB3C Gene

Aliases for RAB3C Gene

  • RAB3C, Member RAS Oncogene Family 2 3 5

External Ids for RAB3C Gene

Previous GeneCards Identifiers for RAB3C Gene

  • GC05P057849
  • GC05P057894
  • GC05P057914
  • GC05P054835

Summaries for RAB3C Gene

Entrez Gene Summary for RAB3C Gene

  • This gene is a member of the RAS oncogene family and encodes a small GTPase. Other similar small GTPases are known to be involved in vesicle trafficking, and the encoded protein was shown to play a role in recycling phagocytosed MHC class 1 complexes to the cell surface. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for RAB3C Gene

RAB3C (RAB3C, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are RAB geranylgeranylation and Metabolism of proteins. GO annotations related to this gene include GTP binding and myosin V binding. An important paralog of this gene is RAB3A.

UniProtKB/Swiss-Prot for RAB3C Gene

  • Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Wiki entry for RAB3C Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB3C Gene

Genomics for RAB3C Gene

Regulatory Elements for RAB3C Gene

Enhancers for RAB3C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G058629 0.9 Ensembl ENCODE 5.9 +47.7 47730 1.4 FOXA3 MAX RAD21 NR2F2 YY1 FOXA1 JUND HNF4G HNF4A BCL6 LINC02108 RAB3C GC05P058707
GH05G058666 0.6 ENCODE 5.4 +85.0 84996 1.9 GATA2 CREB1 MNT FOS FOXP2 NR2F2 GAPT RAB3C GC05P058707
GH05G059063 1.2 FANTOM5 ENCODE 1.8 +481.6 481561 1.5 ELF3 PKNOX1 FOXA2 ATF1 INSM2 FEZF1 ZNF2 RARA CREM MIXL1 ENSG00000247345 RAB3C GC05M059127
GH05G058581 1 ENCODE 0.7 +0.6 613 1.6 ATF1 ZFP64 ZNF133 ARID4B SIN3A ZNF48 YY1 ETS1 GLIS2 ELK1 GAPT RAB3C GC05P058707
GH05G058670 0.4 ENCODE 0.2 +88.6 88623 0.8 JUN FOS GC05P058707 RAB3C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAB3C on UCSC Golden Path with GeneCards custom track

Promoters for RAB3C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000181154 673 1201 ATF1 ZFP64 ZNF133 ARID4B SIN3A ZNF48 YY1 ETS1 GLIS2 ELK1

Genomic Location for RAB3C Gene

Chromosome:
5
Start:
58,582,127 bp from pter
End:
58,859,394 bp from pter
Size:
277,268 bases
Orientation:
Plus strand

Genomic View for RAB3C Gene

Genes around RAB3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB3C Gene

Proteins for RAB3C Gene

  • Protein details for RAB3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96E17-RAB3C_HUMAN
    Recommended name:
    Ras-related protein Rab-3C
    Protein Accession:
    Q96E17

    Protein attributes for RAB3C Gene

    Size:
    227 amino acids
    Molecular mass:
    25952 Da
    Quaternary structure:
    • Interacts with RIMS1, RIMS2, RPH3A and RPH3AL.

neXtProt entry for RAB3C Gene

Post-translational modifications for RAB3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB3C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB3C Gene

Domains & Families for RAB3C Gene

Gene Families for RAB3C Gene

Protein Domains for RAB3C Gene

Suggested Antigen Peptide Sequences for RAB3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96E17

UniProtKB/Swiss-Prot:

RAB3C_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB3C: view

Function for RAB3C Gene

Molecular function for RAB3C Gene

UniProtKB/Swiss-Prot Function:
Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Ontology (GO) - Molecular Function for RAB3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 24891604
GO:0005515 protein binding IPI 24891604
GO:0005525 GTP binding IEA --
GO:0030742 GTP-dependent protein binding IEA --
GO:0031489 myosin V binding IPI 24006491
genes like me logo Genes that share ontologies with RAB3C: view
genes like me logo Genes that share phenotypes with RAB3C: view

Animal Models for RAB3C Gene

MGI Knock Outs for RAB3C:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB3C Gene

Localization for RAB3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB3C Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB3C gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RAB3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IEA --
GO:0008021 synaptic vesicle IEA --
GO:0016020 membrane IEA --
GO:0031982 vesicle IDA 19717423
genes like me logo Genes that share ontologies with RAB3C: view

Pathways & Interactions for RAB3C Gene

genes like me logo Genes that share pathways with RAB3C: view

Pathways by source for RAB3C Gene

Gene Ontology (GO) - Biological Process for RAB3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
GO:0017157 regulation of exocytosis IEA --
GO:0019882 antigen processing and presentation IMP 19717423
genes like me logo Genes that share ontologies with RAB3C: view

No data available for SIGNOR curated interactions for RAB3C Gene

Transcripts for RAB3C Gene

Unigene Clusters for RAB3C Gene

RAB3C, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB3C Gene

No ASD Table

Relevant External Links for RAB3C Gene

GeneLoc Exon Structure for
RAB3C
ECgene alternative splicing isoforms for
RAB3C

Expression for RAB3C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB3C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB3C Gene

This gene is overexpressed in Brain - Hypothalamus (x7.0), Brain - Anterior cingulate cortex (BA24) (x6.9), Brain - Frontal Cortex (BA9) (x6.0), Brain - Cortex (x4.2), and Brain - Nucleus accumbens (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for RAB3C Gene

This gene is overexpressed in Brain (26.8), Frontal cortex (15.4), and Peripheral blood mononuclear cells (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAB3C Gene



Protein tissue co-expression partners for RAB3C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAB3C Gene:

RAB3C

SOURCE GeneReport for Unigene cluster for RAB3C Gene:

Hs.482173

mRNA Expression by UniProt/SwissProt for RAB3C Gene:

Q96E17-RAB3C_HUMAN
Tissue specificity: Expressed in brain, placenta and lung.

Evidence on tissue expression from TISSUES for RAB3C Gene

  • Nervous system(4.6)
  • Lung(4.1)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with RAB3C: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB3C Gene

Orthologs for RAB3C Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB3C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB3C 34 35
  • 99.71 (n)
oppossum
(Monodelphis domestica)
Mammalia RAB3C 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB3C 34 35
  • 93.83 (n)
cow
(Bos Taurus)
Mammalia RAB3C 34 35
  • 91.59 (n)
mouse
(Mus musculus)
Mammalia Rab3c 34 16 35
  • 89.43 (n)
rat
(Rattus norvegicus)
Mammalia Rab3c 34
  • 88.69 (n)
chicken
(Gallus gallus)
Aves RAB3C 34 35
  • 85.32 (n)
lizard
(Anolis carolinensis)
Reptilia RAB3C 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab3c 34
  • 79.3 (n)
zebrafish
(Danio rerio)
Actinopterygii rab3c 34 35
  • 76.04 (n)
wufc17c11 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005255 34
  • 70.34 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rab3 34 35
  • 68.2 (n)
worm
(Caenorhabditis elegans)
Secernentea rab-3 34 35
  • 65.92 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 81 (a)
OneToMany
Species where no ortholog for RAB3C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB3C Gene

ENSEMBL:
Gene Tree for RAB3C (if available)
TreeFam:
Gene Tree for RAB3C (if available)

Paralogs for RAB3C Gene

Variants for RAB3C Gene

Sequence variations from dbSNP and Humsavar for RAB3C Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000014210 -- 58,811,970(+) AGGCT(C/G)AAGCT intron-variant
rs1000015399 -- 58,725,853(+) AATCA(A/T)TAGGG intron-variant
rs1000031180 -- 58,768,403(+) AAATA(C/T)TGTTG intron-variant
rs1000033056 -- 58,627,520(+) AAAAA(A/C)ACAGC intron-variant
rs1000044807 -- 58,775,665(+) GTGAA(G/T)TTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB3C Gene

Variant ID Type Subtype PubMed ID
dgv109n17 CNV loss 16327808
dgv1609e212 CNV loss 25503493
dgv1610e212 CNV loss 25503493
dgv3093n106 CNV deletion 24896259
esv1066632 CNV insertion 17803354
esv1086361 CNV insertion 17803354
esv1096603 CNV insertion 17803354
esv1145647 CNV insertion 17803354
esv1163457 CNV deletion 17803354
esv2124830 CNV deletion 18987734
esv2422174 CNV deletion 20811451
esv2588706 CNV deletion 19546169
esv25926 CNV loss 19812545
esv2664706 CNV deletion 23128226
esv27205 CNV loss 19812545
esv2730219 CNV deletion 23290073
esv2730220 CNV deletion 23290073
esv2730221 CNV deletion 23290073
esv2730222 CNV deletion 23290073
esv2730223 CNV deletion 23290073
esv2730224 CNV deletion 23290073
esv2760929 CNV loss 21179565
esv2760968 CNV loss 21179565
esv2763882 CNV loss 21179565
esv3565963 CNV deletion 23714750
esv3565965 CNV deletion 23714750
esv3570158 CNV loss 25503493
esv3575847 CNV gain 25503493
esv3605160 CNV loss 21293372
esv3605161 CNV loss 21293372
esv3605162 CNV loss 21293372
esv989220 CNV deletion 20482838
nsv1020937 CNV loss 25217958
nsv1109699 CNV deletion 24896259
nsv1111297 CNV tandem duplication 24896259
nsv1120506 CNV tandem duplication 24896259
nsv1125843 CNV tandem duplication 24896259
nsv1125844 CNV tandem duplication 24896259
nsv328987 CNV deletion 16902084
nsv442950 CNV loss 18776908
nsv473206 CNV novel sequence insertion 20440878
nsv4845 CNV deletion 18451855
nsv514306 CNV loss 21397061
nsv598251 CNV loss 21841781
nsv830311 CNV gain 17160897
nsv956504 CNV deletion 24416366
nsv958282 CNV insertion 24416366
nsv965588 CNV deletion 23825009
nsv968177 CNV duplication 23825009

Variation tolerance for RAB3C Gene

Residual Variation Intolerance Score: 34.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB3C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB3C Gene

Disorders for RAB3C Gene

Relevant External Links for RAB3C

Genetic Association Database (GAD)
RAB3C
Human Genome Epidemiology (HuGE) Navigator
RAB3C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB3C

No disorders were found for RAB3C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB3C Gene

Publications for RAB3C Gene

  1. Cloning, mapping, and characterization of the human Rab3C gene. (PMID: 12296628) Cheng H. … Ma Y. (Biochem. Genet. 2002) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Rab18 and a Rab18 GEF complex are required for normal ER structure. (PMID: 24891604) Gerondopoulos A. … Barr F.A. (J. Cell Biol. 2014) 3 64

Products for RAB3C Gene

Sources for RAB3C Gene

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